Nucleic acids, proteins, and antibodies

ABSTRACT

The present invention relates to novel reproductive system related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as “reproductive system related antigens,” and the use of such reproductive system related antigens for detecting disorders of the reproductive system, particularly the presence of cancers and cancer metastases. More specifically, isolated reproductive system associated nucleic acid molecules are provided encoding novel reproductive system associated polypeptides. Novel reproductive system related polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human reproductive system associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the reproductive system, including reproductive system cancers, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

[0001] This application refers to a “Sequence Listing” listed below, which is provided as an electronic document on two identical compact discs (CD-R), labeled “Copy 1” and “Copy 2.” These compact discs each contain the following files, which are hereby incorporated in their entirety herein: Document File Name Size in bytes Date of Creation Sequence Listing PC006_seqList.txt 20,399,935   01/15/2001 V Viewer Setup File SetupDLL.exe 695,808 12/19/2000 V Viewer Help File Controller v.cnt  7,984 01/05/2001 V Viewer Program File v.exe 753,664 12/19/2000 V Viewer Help File v.hlp 447,766 01/05/2001

[0002] The Sequence Listing may be viewed on an IBM-PC machine running the MS-Windows operating system by using the V viewer software, licensed by HGS, Inc., included on the compact discs (see World Wide Web URL: http://www.fileviewer.com).

FIELD OF THE INVENTION

[0003] The present invention relates to novel reproductive system related polynucleotides, the polypeptides encoded by these polynucleotides herein collectively referred to as “reproductive system antigens,” and antibodies that immunospecifically bind these polypeptides, and the use of such reproductive system polynucleotides, antigens, and antibodies for detecting, treating, preventing and/or prognosing disorders of the reproductive system, including, but not limited to, the presence of cancer and cancer metastases. More specifically, isolated reproductive system nucleic acid molecules are provided encoding novel reproductive system polypeptides. Novel reproductive system polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human reproductive system polynucleotides, polypeptides, and/or antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the reproductive system, including cancers of the reproductive system, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The invention further relates to methods and/or compositions for inhibiting or promoting the production and/or function of the polypeptides of the invention.

BACKGROUND OF THE INVENTION

[0004] The human reproductive system enables continuation of the species. Human beings reproduce sexually, require the involvement of both a male and a female. Reproduction involves the coalition of sex cells. A new human being begins its development after a sex cell (sperm), created by the male unites with a sex cell (ovum) created by the female. Both the male and female reproductive systems function through the complex interaction of several organs. Diseases or malfunctions of these organs can impair reproduction or cause infertility.

[0005] The Male Reproductive System

[0006] Male reproductive functions can be divided into three major subdivisions; spermatogenesis (the formation and maturation of sperm), performance of the male sexual act (arousal, erection, and ejaculation), and regulation of male sexual functions by the various hormones (mainly testosterone). Associated with these reproductive functions are the effects of the male sex hormones on the accessory sexual organs, cellular metabolism, growth, and on several other bodily functions. The onset of sexual maturation and these reproductive functions in males occurs at puberty, which, in humans, typically begins around age thirteen.

[0007] The male reproductive system is composed of the testes, a pair of organs contained in the scrotum which include the seminiferous tubules and epididymus; secretory glands, such as the prostate gland, seminal vesicles, bulbourethral glands, and urethral glands; tubular passageways, such as the vas deferens and urethra; and the penis, which functions in performance of the sexual act and sperm transmission.

[0008] Common disorders of the male reproductive system include infections, cancers, and inflammations of the above listed components, which are described in greater detail below.

[0009] Disorders of the Testes

[0010] The two primary functions of the testes are 1) production of testosterone and 2) production of sperm. Testosterone produced in the testes is released into the blood stream, where it travels to and acts on a wide range of tissues and organs within the male body. Disorders resulting from testosterone deficiency are manifested in the male reproductive system typically by symptoms of hypogonadism, which is the failure to go through puberty. Specifically, erectile function is impaired, and libido and sperm production are decreased or absent.

[0011] Known dysfunctions of sperm production include aspermia (the failure to produce an ejaculate), asthenospermia (the production of an ejaculate in which less than 50% of spermatozoa are motile), azoospermia (the production of an ejaculate devoid of spermatozoa), oligospermia (production of an ejaculate containing less than 20×100 spermatozoa per milliliter of semen), and teratospermia (the production of an ejaculate in which more than 50% of the spermatozoa are of abnormal shape), all of which result in impaired fertility. Improper sperm formation may result from a variety of factors, including congenital defects, genetic abnormalities, injury, and infection. For example, contraction of the mumps virus early in male adolescence can infect the testicles, leading to permanent complications in sperm production.

[0012] Sperm formation may also be impaired by disorders of the epididymus, the labyrinthine tube system located in each testis where sperm mature. Common disorders include infections (e.g., Neisseria gonorrhoea, Pseudomonas, Enterobacteriaceae, and Chlamydia trachomatis), cyst formation or other obstructions, and enlargement of the spermatoceles (liquid filled cavities in the epididymus).

[0013] During fetal development, the testes mature within the abdominal cavity and descend through the inguinal canal into the scrotum prior to birth. It is well known that the testicles reside in the scrotum because it is cooler than other places within the body cavity, and even minor temperature differences can have a dramatic influence on the ability of the testicle to make sperm. An undescended testicle, sometimes called a cryptorchid testicle, is a fairly common problem in male babies. Typically, testicles undescended at birth will move into the scrotum within the first year of life, however in a small percentage of cases this migration does not occur. Early correction of this problem is crucial in preserving the fertility of the male, as the testicles begin to loose the ability to make sperm very early in life in they are not properly stored in the scrotum. Additionally, undescended testicles have a much higher rate of developing testicular cancer than testicles that descended spontaneously. Testicular cancer is the most common solid tumor in males aged 18 to 35. It typically is extremely aggressive and spreads early. A tumor of the testicle often shows itself by a fast enlargement of the testicle. Bringing the testes into the scrotum will allow for easier and more accurate examination of the testes, hopefully resulting in earlier detection of tumors. Further, undescended testicles are also associated with a greater risk of hernia.

[0014] Disorders of the scrotal pouch commonly involve the small amount of fluid lining the pouch that allows for small movements and cushioning of the testicles. Several causes, such as testicular torsion, trauma, or tumors, may lead to an increase in the amount of liquid, causing the scrotal pouch to bulge. While this condition is harmless, it may cause irritation and discomfort if the bulge becomes too large.

[0015] Another harmless, yet irritating disease of the testes is varicocele, a disorder of the small vein that run the blood from the testicle back toward the heart. Small valves are present in these veins to prevent blood from flowing back toward the testicles. Sometimes, these valves malfunction, causing backflow and subsequent enlargement of the small vessel network in the scrotal sac. This gives rise to dull pain and an uncomfortable “bag of worms” feeling around the scrotum. There is currently considerable debate as to whether this phenomenon also contributes to decreased fertility.

[0016] Disorders of the Vas Deferens and Seminal Vesicles

[0017] In the vas deferens, the sperm become mixed with a viscous, alkaline fluid from the seminal vesicles that constitutes 60% of semen. This fluid contains the components for generating sperm motility and the enzymes necessary for fertilization of the egg within the female reproductive system. Disorders of the vas deferens and seminal vesicles are unusual, however a congenital defect where the vas deferens is absent is known to be associated with mutations in the CFTR gene, and a defect in seminal vesicle function is associated with the hydatid disease of the urogenital system.

[0018] Disorders of the Prostate Gland

[0019] Disorders of the prostate gland are typically manifested by enlargement of the gland, leading to such symptoms as impaired urinary flow, infertility, and pain. For example, benign prostatic hyperplasia is the non-cancerous growth of the prostate gland, a condition that is fairly common in men over sixty. Prostate cancer, too, is extremely prevalent and is now the second most common type of cancer in males. Although men of any age can develop prostate cancer, it is found most frequently in men over age 50. Types of prostate cancers include, but not limited to, adenocarcinomas, transitional cell carcinomas, ductal carcinomas, and squamous cell carcinomas. The prostate is subject to infections or inflammation, which may also result in enlargement of the prostate, such as acute bacterial prostatitis, chronic bacterial prostatitis, and nonbacterial prostatitis.

[0020] Disorders of the Penis and Urethra

[0021] During sexual activity, the penis becomes rigid and erect, enabling penetration and deposition of sperm. An erection results from complex interaction of neurologic, vascular, hormonal, and psychologic actions. Several types of infections and inflammatory disorders can effect the penis and its function. Balanoposthitis is a generalized inflammation of the head of the penis (glans penis) and foreskin, commonly caused by a yeast or bacterial infection beneath the foreskin of an uncircumcised penis. Symptoms include pain, itching, redness, and swelling and can ultimately lead to a narrowing (stricture) of the urethra. Other infectious and inflammatory disorders, such as balanitis xerotica obliterans (a hardening of the tip of the penis which ultimately blocks urine and semen flow), phimosis (the shrinking or tightening of the foreskin), paraphimosis (inability of the retracted foreskin to be pulled back over the head of the penis), and Erythroplasia of Queyrat (an infection causing a clearly defined reddish, velvety area on the skin of the penis). If left untreated, many of these infections may become cancerous.

[0022] Other infections can lead to penile growths, such as the small painless sores associated with syphilis, tiny blisters from the herpes simplex virus, firm nodules from genital warts, and dimpled growths (molluscum contagiosum) from an unknown virus. Small sores and growths are also associated with skin cancers (e.g., squamous cell carcinoma, Bowen's disease, and Paget's disease) that can occur anywhere on the penis.

[0023] The causes of the two major erectile disorders are not well understood. Priapism is a painful, persistant erection unaccompanied by sexual desire or excitement. In most cases, priapism is believed to stem from habitual drug use, but is had also been associated with blood disorders (e.g., blood clots, leukemia, or sickle cell disease), tumors in the pelvis or spine, and infection of the genitals. Peyronie's disease is manifested as a fibrous thickening of tissue that causes the penis to develop contractures so that the shape of an erection is distorted. The curvature of the erect penis can make sexual penetration difficult or impossible and may make erections extremely painful. Current therapies include corticosteroid injections, ultrasound treatments, or, more commonly, surgery, which may lead to impotence.

[0024] Impotence, or erectile dysfunction, is the consistent or recurrent inability to attain and maintain a penile erection rigid enough for satisfactory sexual intercourse. Erectile dysfunction relates only to the erectile capability of the penis, excluding problems of libido, ejaculation, and orgasm. It is now accepted that the majority of cases have a physical and not a psychogenic root. Physical causes include anatomic deformations (e.g., malformed genitalia or penile injury), diabetes mellitus, coronary disease, hypertension, atherosclerosis, high cholesterol levels, multiple sclerosis, stroke, lower spine diseases, and rectal or prostate surgery.

[0025] The Female Reproductive System

[0026] The female reproductive system is comprised of both external and internal organs. The external organs function in permitting sperm to enter the body and protecting the internal genital organs from infection and injury. The internal organs form a pathway (the genital tract) for reproduction, beginning at the ovaries, through the fallopian tubes (oviducts) and uterus, to the birth canal (vagina).

[0027] The sexual and reproductive functions in the female can be divided into two major phases: first, preparation of the body for conception, and second, the gestation and parturition. Gestation and parturition only occur if an ovum becomes fertilized. If fertilization does not occur, the reproductive system undergoes a cycle to ensure frequent readiness for conception and fertilization.

[0028] Common disorders of the female reproductive system include infections, cancers, and inflammations of the organs, which are described in greater detail below.

[0029] Disorders of the Uterus

[0030] Disorders of the uterus include absent bleeding (amenorrhea) and abnormal bleeding. Amenorrhea is normal only before puberty, during pregnancy, while breastfeeding, and after menopause. The absence of menses at other times is considered aberrant and may be indicative of problems in the brain, pituitary gland, thyroid gland, adrenal glands, ovaries, or virtually any other part of the reproductive tract. For example, the hypothalamus signals the pituitary gland to release hormones that cause the ovaries to release eggs. Inappropriately low levels of hypothalamic hormones prevent egg release, halting the menstrual cycle. The same is true for the thyroid and adrenal glands. To illustrate, in Cushing's syndrome, excess production of cortisol by the adrenal glands causes periods to be absent or irregular. The absence of periods can also be caused by growths (e.g., hydatidiform moles) or scarring of the uterine lining due to infection or surgery (e.g., Asherman's syndrome).

[0031] Some women do not undergo puberty at all—consequently their periods never start. Causes include a birth defect in which the uterus or fallopian tubes develop abnormally and chromosomal disorders. For example, in Turner's syndrome, the female was formed from a zygote containing only one X chromosome and shows reproductive abnormalities, such as amenorrhea and chronically immature breasts, labia, vagina.

[0032] Premature menopause is also a condition resulting in amenorrhea. Menopause is considered abnormal when it occurs in women under the age of forty. Causes of premature menopause include genetic (usually chromosomal) abnormalities and autoimmune disorders in which antibodies damage the ovaries. Estrogen replacement therapy can prevent or reverse the symptoms of menopause, however the chance of conceiving a child remains less than ten percent.

[0033] Uterine bleeding is considered abnormal when it is atypically heavy, light, frequent, or irregular. Moreover, bleeding before puberty or after menopause is almost always abnormal. Uterine polyps, fibroids (noncancerous growths of muscle and fibrous tissues), and cancers are common causes of abnormal uterine bleeding and usually can be surgically removed. Cancers of the uterus include adenocarcinomas (cancers arising from the endometrial lining), leiomyosarcomas (cancers of the uterine smooth muscle), and sarcomas (cancers arising from the stroma).

[0034] Aberrant bleeding resulting from hormonal irregularities (commonly referred to a dysfunctional uterine bleeding) occurs most frequently at the beginning and end of the reproductive years and typically results from sustained levels of estrogen. For example, in polycystic ovary syndrome the overproduction of luteinizing hormone stimulates the production of large amounts of androgens—some of which are converted to estrogen-which, without sufficient progesterone to counteract its effects, induces abnormal uterine bleeding.

[0035] Endometriosis is a disorder of the uterus in which patches of endometrial tissue, which normally is found only in the uterine lining, grow outside the uterus. Because the misplaced tissue responds to the same hormone that the uterus responds to, it may bleed during the menstrual period, causing cramps, pain, irritation, and the formation of scar tissue. As the disease progresses, adhesions may form and block the functioning of organs.

[0036] Disorders of uterine contraction include, for example, dysmenorrhea and pre-term labor. During a normal period, the uterus undergoes mild contractions in order to aid in blood flow. Dysmenorrhea results when the contractions become inappropriately strong, inhibiting blood flow to the uterus. This deprives uterine muscle of oxygen, causing severe abdominal pain, as well as nausea, vomiting, diarrhea, headaches, weakness, and/or fainting. Sever cases of dysmenorrhea can significantly disrupt a womans life, leading to heavy work/school absenteeism and cases of pain killer addiction. Pre-term labor is also aserious problem, resulting in a dramatic rise in associated infant morbidity and mortality (83% of infant deaths occur in gestations less than 37 weeks). Therapies for extending the length of pregnancy beyond 32 weeks, and preferably beyond 36 weeks, could significantly reduce the incidence of neonatal morbidity and virtually eliminate a major cause of neonatal mortality.

[0037] Disorders of the Ovary

[0038] Anovulation (the absence of egg release by the ovaries) is a serious condition leading to infertility. The exact etiology of anovulation, especially in women with otherwise normal menstrual cycles, is unclear, however several potential causes are under study, including: impaired follicular development (probably due to low or absent estrogen production or binding), normal follicular development with lack of egg release (probably due to progesterone deficiency), or insufficient production of gonadotropin-releasing hormone from the hypothalamus. Current treatments include clomiphene injections or hormonal therapy, although both can lead to serious side effects such as ovarian cancer and ovarian hyperstimulation syndrome.

[0039] Anovulation is also associated with polycyctic ovary syndrome (also known as Stein-Leventhal syndrome). This syndrome is and endocrine disorder characterized by an elevated level of male hormones (androgens). Other than anovulation, symptoms include growth of male-patterned body hair (hirsutism), excessive acne, irregular or absent menses, excessive bleeding, and obesity. Usually, the ovaries appear enlarged and may contain many follicular cysts.

[0040] Ovarian cancer develops most often in women between the ages of 50 and 70. It is the third most common cancer of the female reproductive system, but more women die of ovarian cancers than of any other. Ovaries include a variety of cell types, each of which may give rise to a distinct type of cancer, including, but not limited to, ovarian epithelial cancer, ovarian germ cell tumors, ovarian papillary serous adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian Krukenberg tumor, malignant mixed Mullerian tumors, and ovarian low malignant tumors.

[0041] Other disorders of the ovaries also include, but are not limited to, inflammatory disorders, such as oophoritis (e.g., caused by viral or bacterial infection), ovarian cysts, and autoimmune disorders (e.g., premature ovarian failure and autoimmune oophoritis).

[0042] Disorders of the Vagina and Vulva

[0043] The vagina and vulva are self-cleaning. Secretions and discharges flow downward through the vagina and vulva, flushing out dead cells and other substances. Despite this cleaning mechanism, infections and inflammation are a common problem. The most common vaginal infections are bacterial vaginitis, candida vaginitis (e.g., yeast infections), trichomonas vaginitis, and vulvitis. Vaginal or vulvar itching, irritation, and abnormal discharge characterize all.

[0044] Cancer of the vagina is extremely rare, accounting for only two percent of all gynecological cancers, and occurs primarily in women over the age of 50. The severity of the disease depends on the type of cancer and its exact location. Varieties include, for example, squamous cell carcinoma and clear cell adenocarcinoma. Once cancer appears in the vagina, it easily spreads to surrounding tissues. Vulvar cancer is equally unusual as vaginal, and is predominantly manifested as a form of skin cancer, e.g. squamous cell carcinomas and basal cell carcinomas. Other vulvar cancers include Paget's disease, cancer of Bartholin's gland, and melanomas. Unlike cancer of the vagina, vulvar cancers typically grow slowly and infrequently metastasize.

[0045] Disorders of the Breast

[0046] Disorders of the breast typically involve the formation of lesions within breast tissue. While many of these lesions are benign in nature, they may lead to cancer if left untreated.

[0047] Benign breast lesions include, for example, cysts, which are non-cancerous, fluid-filled sacs that forma mass within breast tissue. The cause of breast cysts is unknown, though injury may be involved, and their main symptom is pain. While considered harmless, a professional should drain cysts and the fluid examined because cancer of the cyst wall, although quite rare, is possible.

[0048] Other benign breast lesions include fibrous breast lumps (fibroadenomas), breast infection (mastitis), intraductal papilloma, and abscesses. Fibrous breast lumps are small, solid lumps of glandular tissue. These lumps usually appear in young women, often in teenagers, and are easy to remove. Intraductal papilloma are small lumps located within a milk duct, often causing inappropriate discharge from the nipple. Breast abscesses are collections of pus in breast tissue that develop from breast infections that go untreated.

[0049] Breast cancer is the most common cancer among women, other than skin cancer and is the second leading cause of cancer death in women, after lung cancer. The American Cancer Society predicts that there will be about 182,800 new cases of invasive breast cancer in the year 2000 among women in this country and about 40,800 deaths from the disease. Breast cancer also occurs among men, although much less often. It is generally believed that this malignancy arises from a multi step process involving mutations in a relatively small number of genes, perhaps 10 or less. These mutations result in significant changes in the growth and differentiation of breast tissue that allow it to grow independent of normal cellular controls, to metastasize, and to escape immune surveillance. The genetic heterogeneity of most breast cancers suggests that they arise by a variety of initiating events and that the characteristics of individual cancers are due to the collective pattern of genetic changes that accumulate.

[0050] The discovery of new human reproductive system associated polynucleotides, the polypeptides encoded by them, and antibodies that immunospecifically bind these polypeptides, satisfies a need in the art by providing new compositions which are useful in the diagnosis, treatment, prevention and/or prognosis of disorders of the reproductive system, including, but not limited to, disorders of the male reproductive system including, for example, testicular disorders (e.g., hypogonadism, infection (e.g, Neisseria gonorrhoea, Enterobacteriaceae, and/or as described in the “Reproductive System Disorders” section below), asthenospermia, teatospermia, cryptorchid testicle, testicular cancers, varicocele, and/or as described in the “Reproductive System Disorders” section below), prostate disorders (e.g., prostate cancers, benign prostatic hyperplasia, and/or as described in the “Reproductive System Disorders” section below), disorders of the penis (e.g., balanoposthitis, phimosis, genital warts, skin cancer, priapism, Peyronie's disease, erectile dysfunction, and/or as described in the “Reproductive System Disorders” section below); and disorders of the female reproductive system including, for example, disorders of the uterus (e.g., Cushing's syndrome, Asherman's syndrome, Turner's syndrome, premature menopause, uterine cancers, endometriosis, and/or as described in the “Reproductive System Disorders” section below), ovarian disorders (e.g., anovulation, polycystic ovary syndrome, ovarian cancers, and/or as described in the “Reproductive System Disorders” section below), vaginal and vulvar disorders (e.g., vulvitis, vaginal infections, Paget's disease, cancers of the vagina and vulva, and/or as described in the “Reproductive System Disorders” section below), and breast disorders (e.g., breast cancers, fibroadenomas, intraductal papillomas, and/or as described in the “Reproductive System Disorders” section below).

SUMMARY OF THE INVENTION

[0051] The present invention relates to novel reproductive system related polynucleotides, the polypeptides encoded by these polynucleotides herein collectively referred to as “reproductive system antigens,” and antibodies that immunospecifically bind these polypeptides, and the use of such reproductive system polynucleotides, antigens, and antibodies for detecting, treating, preventing and/or prognosing disorders of the reproductive system, including, but not limited to, the presence of cancer and cancer metastases. More specifically, isolated reproductive system nucleic acid molecules are provided encoding novel reproductive system polypeptides. Novel reproductive system polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human reproductive system polynucleotides, polypeptides, and/or antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the reproductive system, including cancers of the reproductive system, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The invention further relates to methods and/or compositions for inhibiting or promoting the production and/or function of the polypeptides of the invention.

DETAILED DESCRIPTION

[0052] Tables

[0053] Table 1A summarizes some of the polynucleotides encompassed by the invention (including cDNA clones related to the sequences (Clone ID NO: Z), contig sequences (contig identifier (Contig ID:) and contig nucleotide sequence identifier (SEQ ID NO: X)) and further summarizes certain characteristics of these polynucleotides and the polypeptides encoded thereby. The first column provides a unique clone identifier, “Clone ID NO: Z”, for a cDNA plasmid related to each reproductive system associated contig sequence disclosed in Table 1A. The second column provides a unique contig identifier, “Contig ID:” for each of the contig sequences disclosed in Table 1A. The third column provides the sequence identifier, “SEQ ID NO: X”, for each of the contig polynucleotide sequences disclosed in Table 1A. The fourth column, “ORF (From-To)”, provides the location (i.e., nucleotide position numbers) within the polynucleotide sequence of SEQ ID NO: X that delineate the preferred open reading frame (ORF) shown in the sequence listing and referenced in Table 1A as SEQ ID NO: Y (column 5). Column 6 lists residues comprising predicted epitopes contained in the polypeptides encoded by each of the preferred ORFs (SEQ ID NO: Y). Identification of potential immunogenic regions was performed according to the method of Jameson and Wolf (CABIOS, 4:181-186 (1988)); specifically, the Genetics Computer Group (GCG) implementation of this algorithm, embodied in the program PEPTIDESTRUCTURE (Wisconsin Package v10.0, Genetics Computer Group (GCG), Madison, Wis.). This method returns a measure of the probability that a given residue is found on the surface of the protein. Regions where the antigenic index score is greater than 0.9 over at least 6 amino acids are indicated in Table 1A as “Predicted Epitopes.” In particular embodiments, reproductive system associated polypeptides of the invention comprise, or alternatively consist of, one, two, three, four, five or more of the predicted epitopes described in Table 1A. It will be appreciated that depending on the analytical criteria used to predict antigenic determinants, the exact address of the determinant may vary slightly. Column 7, “Tissue Distribution” shows the expression profile of tissue, cells, and/or cell line libraries which express the polynucleotides of the invention. The first number in column 7 (preceding the colon), represents the tissue/cell source identifier code corresponding to the code and description provided in Table 4. Expression of these polynucleotides was not observed in the other tissues and/or cell libraries tested. For those identifier codes in which the first two letters are not “AR”, the second number in column 7 (following the colon), represents the number of times a sequence corresponding to the reference polynucleotide sequence (e.g., SEQ ID NO: X) was identified in the tissue/cell source. Those tissue/cell source identifier codes in which the first two letters are “AR” designate information generated using DNA array technology. Utilizing this technology, cDNAs were amplified by PCR and then transferred, in duplicate, onto the array. Gene expression was assayed through hybridization of first strand cDNA probes to the DNA array. cDNA probes were generated from total RNA extracted from a variety of different tissues and cell lines. Probe synthesis was performed in the presence of ³³P dCTP, using oligo(dT) to prime reverse transcription. After hybridization, high stringency washing conditions were employed to remove non-specific hybrids from the array. The remaining signal, emanating from each gene target, was measured using a Phosphorimager. Gene expression was reported as Phosphor Stimulating Luminescence (PSL) which reflects the level of phosphor signal generated from the probe hybridized to each of the gene targets represented on the array. A local background signal subtraction was performed before the total signal generated from each array was used to normalize gene expression between the different hybridizations. The value presented after “[array code]:” represents the mean of the duplicate values, following background subtraction and probe normalization. One of skill in the art could routinely use this information to identify normal and/or diseased tissue(s) which show a predominant expression pattern of the corresponding polynucleotide of the invention or to identify polynucleotides which show predominant and/or specific tissue and/or cell expression. Column 8, “Cytologic Band,” provides the chromosomal location of polynucleotides corresponding to SEQ ID NO: X. Chromosomal location was determined by finding exact matches to EST and cDNA sequences contained in the NCBI (National Center for Biotechnology Information) UniGene database. Given a presumptive chromosomal location, disease locus association was determined by comparison with the Morbid Map, derived from Online Mendelian Inheritance in Man (Online Mendelian Inheritance in Man, OMIM™. McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University (Baltimore, Md.) and National Center for Biotechnology Information, National Library of Medicine (Bethesda, Md.) 2000. World Wide Web URL: http://www.ncbi.nhn.nih.gov/omim/). If the putative chromosomal location of the Query overlapped with the chromosomal location of a Morbid Map entry, an OMIM identification number is provided in Table 1A, column 9 labeled “OMIM Disease Reference(s)”. A key to the OMIM reference identification numbers is provided in Table 5.

[0054] Table 1B summarizes additional polynucleotides encompassed by the invention (including cDNA clones related to the sequences (Clone ID NO: Z), contig sequences (contig identifier (Contig ID:) contig nucleotide sequence identifiers (SEQ ID NO: X)), and genomic sequences (SEQ ID NO: B). The first column provides a unique clone identifier, “Clone ID NO: Z”, for a cDNA clone related to each contig sequence. The second column provides the sequence identifier, “SEQ ID NO: X”, for each contig sequence. The third column provides a unique contig identifier, “Contig ID:” for each contig sequence. The fourth column, provides a BAC identifier “BAC ID NO: A” for the BAC clone referenced in the corresponding row of the table. The fifth column provides the nucleotide sequence identifier, “SEQ ID NO: B” for a fragment of the BAC clone identified in column four of the corresponding row of the table. The sixth column, “Exon From-To”, provides the location (i.e., nucleotide position numbers) within the polynucleotide sequence of SEQ ID NO: B which delineate certain polynucleotides of the invention that are also exemplary members of polynucleotide sequences that encode polypeptides of the invention (e.g., polypeptides containing amino acid sequences encoded by the polynucleotide sequences delineated in column six, and fragments and variants thereof).

[0055] Table 2 summarizes homology and features of some of the polypeptides of the invention. The first column provides a unique clone identifier, “Clone ID NO: Z”, corresponding to a cDNA disclosed in Table 1A. The second column provides the unique contig identifier, “Contig ID:” corresponding to contigs in Table 1A and allowing for correlation with the information in Table 1A. The third column provides the sequence identifier, “SEQ ID NO: X”, for the contig polynucleotide sequences. The fourth column provides the analysis method by which the homology/identity disclosed in the row was determined. Comparisons were made between polypeptides encoded by the polynucleotides of the invention and either a non-redundant protein database (herein referred to as “NR”), or a database of protein families (herein referred to as “PFAM”) as further described below. The fifth column provides a description of PFAM/NR hits having significant matches to a polypeptide of the invention. Column six provides the accession number of the PFAM/NR hit disclosed in the fifth column. Column seven, “Score/Percent Identity”, provides a quality score or the percent identity, of the hit disclosed in column five. Columns 8 and 9, “NT From” and “NT To” respectively, delineate the polynucleotides in “SEQ ID NO: X” that encode a polypeptide having a significant match to the PFAM/NR database as disclosed in the fifth column. In specific embodiments, polypeptides of the invention comprise, or alternatively consist of, an amino acid sequence encoded by the polynucleotides in SEQ ID NO: X as delineated in columns 8 and 9, or fragments or variants thereof.

[0056] Table 3 provides polynucleotide sequences that may be disclaimed according to certain embodiments of the invention. The first column provides a unique clone identifier, “Clone ID NO: Z”, for a cDNA clone related to reproductive system associated contig sequences disclosed in Table 1A. The second column provides the sequence identifier, “SEQ ID NO: X”, for contig polynucleotide sequences disclosed in Table 1A. The third column provides the unique contig identifier, “Contig ID”, for contigs disclosed in Table 1A. The fourth column provides a unique integer ‘a’ where ‘a’ is any integer between 1 and the final nucleotide minus 15 of SEQ ID NO: X, represented as “Range of a”, and the fifth column provides a unique integer ‘b’ where ‘b’ is any integer between 15 and the final nucleotide of SEQ ID NO: X, represented as “Range of b”, where both a and b correspond to the positions of nucleotide residues shown in SEQ ID NO: X, and where b is greater than or equal to a +14. For each of the polynucleotides shown as SEQ ID NO: X, the uniquely defined integers can be substituted into the general formula of a−b, and used to describe polynucleotides which may be preferably excluded from the invention. In certain embodiments, preferably excluded from the polynucleotides of the invention (including polynucleotide fragments and variants as described herein and diagnostic and/or therapeutic uses based on these polynucleotides) are at least one, two, three, four, five, ten, or more of the polynucleotide sequence(s) having the accession number(s) disclosed in the sixth column of this Table (including for example, published sequence in connection with a particular BAC clone). In further embodiments, preferably excluded from the invention are the specific polynucleotide sequence(s) contained in the clones corresponding to at least one, two, three, four, five, ten, or more of the available material having the accession numbers identified in the sixth column of this Table (including for example, the actual sequence contained in an identified BAC clone).

[0057] Table 4 provides a key to the tissue/cell source identifier code disclosed in Table 1A, column 7. Column 1 provides the key to the tissue/cell source identifier code disclosed in Table 1A, Column 7. Columns 2-5 provide a description of the tissue or cell source. Codes corresponding to diseased tissues are indicated in column 6 with the word “disease”. The use of the word “disease” in column 6 is non-limiting. The tissue or cell source may be specific (e.g. a neoplasm), or may be disease-associated (e.g., a tissue sample from a normal portion of a diseased organ). Furthermore, tissues and/or cells lacking the “disease” designation may still be derived from sources directly or indirectly involved in a disease state or disorder, and therefore may have a further utility in that disease state or disorder. In numerous cases where the tissue/cell source is a library, column 7 identifies the vector used to generate the library.

[0058] Table 5 provides a key to the OMIM™ reference identification numbers disclosed in Table 1A, column 9. OMIM reference identification numbers (Column 1) were derived from Online Mendelian Inheritance in Man (Online Mendelian Inheritance in Man, OMIM™. McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University (Baltimore, Md.) and National Center for Biotechnology Information, National Library of Medicine, (Bethesda, Md.) 2000. World Wide Web URL: http://www.ncbi.nlm.nih.gov/omim/). Column 2 provides diseases associated with the cytologic band disclosed in Table 1A, column 8, as determined from the Morbid Map database.

[0059] Table 6 summarizes ATCC Deposits, Deposit dates, and ATCC designation numbers of deposits made with the ATCC in connection with the present application.

[0060] Table 7 shows the cDNA libraries sequenced, tissue source description, vector information and ATCC designation numbers relating to these cDNA libraries.

[0061] Table 8 provides a physical characterization of clones encompassed by the invention. The first column provides the unique clone identifier, “Clone ID NO: Z”, for certain cDNA clones of the invention, as described in Table 1A. The second column provides the size of the cDNA insert contained in the corresponding cDNA clone.

[0062] Definitions

[0063] The following definitions are provided to facilitate understanding of certain terms used throughout this specification.

[0064] In the present invention, “isolated” refers to material removed from its original environment (e.g., the natural environment if it is naturally occurring), and thus is altered “by the hand of man” from its natural state. For example, an isolated polynucleotide could be part of a vector or a composition of matter, or could be contained within a cell, and still be “isolated” because that vector, composition of matter, or particular cell is not the original environment of the polynucleotide. The term “isolated” does not refer to genomic or cDNA libraries, whole cell total or MRNA preparations, genomic DNA preparations (including those separated by electrophoresis and transferred onto blots), sheared whole cell genomic DNA preparations or other compositions where the art demonstrates no distinguishing features of the polynucleotide sequences of the present invention.

[0065] As used herein, a “polynucleotide” refers to a molecule having a nucleic acid sequence encoding SEQ ID NO: Y or a fragment or variant thereof, a nucleic acid sequence contained in SEQ ID NO: X (as described in column 3 of Table 1A) or the complement thereof, a cDNA sequence contained in Clone ID NO: Z (as described in column 1 of Table 1A and contained within a library deposited with the ATCC); a nucleotide sequence encoding the polypeptide encoded by a nucleotide sequence in SEQ ID NO: B as defined in column 6 of Table 1B or a fragment or variant thereof; or a nucleotide coding sequence in SEQ ID NO: B as defined in column 6 of Table 1B or the complement thereof. For example, the polynucleotide can contain the nucleotide sequence of the fill length cDNA sequence, including the 5′ and 3′ untranslated sequences, the coding region, as well as fragments, epitopes, domains, and variants of the nucleic acid sequence. Moreover, as used herein, a “polypeptide” refers to a molecule having an amino acid sequence encoded by a polynucleotide of the invention as broadly defined (obviously excluding poly-Phenylalanine or poly-Lysine peptide sequences which result from translation of a polyA tail of a sequence corresponding to a cDNA).

[0066] As used herein, a “reproductive system antigen” refers collectively to any polynucleotide disclosed herein (e.g., a nucleic acid sequence contained in SEQ ID NO: X or the complement therof, or cDNA sequence contained in Clone ID NO: Z, or a nucleotide sequence encoding the polypeptide encoded by a nucleotide sequence in SEQ ID NO: B as defined in column 6 of Table 1B, or a nucleotide coding sequence in SEQ ID NO: B as defined in column 6 of Table 1B or the complement thereof and fragments or variants thereof as described herein) or any polypeptide disclosed herein (e.g., an amino acid sequence contained in SEQ ID NO: Y, an amino acid sequence encoded by SEQ ID NO: X, or the complement thereof, an amino acid sequence encoded by the cDNA sequence contained in Clone ID NO: Z, an amino acid sequence encoded by SEQ ID NO: B, or the complement thereof, and fragments or variants thereof as described herein). These reproductive system antigens have been determined to be predominantly expressed in reproductive system tissues, including normal or diseased tissues (as shown in Table 1A column 7 and Table 4).

[0067] In the present invention, “SEQ ID NO: X” was often generated by overlapping sequences contained in multiple clones (contig analysis). A representative clone containing all or most of the sequence for SEQ ID NO: X is deposited at Human Genome Sciences, Inc. (HGS) in a catalogued and archived library. As shown, for example, in column 1 of Table 1A, each clone is identified by a cDNA Clone ID (identifier generally referred to herein as Clone ID NO: Z). Each Clone ID is unique to an individual clone and the Clone ID is all the information needed to retrieve a given clone from the HGS library. Furthermore, certain clones disclosed in this application have been deposited with the ATCC on Oct. 5, 2000, having the ATCC designation numbers PTA 2574 and PTA 2575; and on Jan. 5, 2001, having the depositor reference numbers TS-1, TS-2, AC-1, and AC-2. In addition to the individual cDNA clone deposits, most of the cDNA libraries from which the clones were derived were deposited at the American Type Culture Collection (hereinafter “ATCC”). Table 7 provides a list of the deposited cDNA libraries. One can use the Clone ID NO: Z to determine the library source by reference to Tables 6 and 7. Table 7 lists the deposited cDNA libraries by name and links each library to an ATCC Deposit. Library names contain four characters, for example, “HTWE.” The name of a cDNA clone (Clone ID NO: Z) isolated from that library begins with the same four characters, for example “HTWEP07”. As mentioned below, Table 1A correlates the Clone ID NO: Z names with SEQ ID NO: X. Thus, starting with an SEQ ID NO: X, one can use Tables 1A, 6 and 7 to determine the corresponding Clone ID NO: Z, which library it came from and which ATCC deposit the library is contained in. Furthermore, it is possible to retrieve a given cDNA clone from the source library by techniques known in the art and described elsewhere herein. The ATCC is located at 10801 University Boulevard, Manassas, Va. 20110-2209, USA. The ATCC deposits were made pursuant to the terms of the Budapest Treaty on the international recognition of the deposit of microorganisms for the purposes of patent procedure.

[0068] In specific embodiments, the polynucleotides of the invention are at least 15, at least 30, at least 50, at least 100, at least 125, at least 500, or at least 1000 continuous nucleotides but are less than or equal to 300 kb, 200 kb, 100 kb, 50 kb, 15 kb, 10 kb, 7.5 kb, 5 kb, 2.5 kb, 2.0 kb, or 1 kb, in length. In a further embodiment, polynucleotides of the invention comprise a portion of the coding sequences, as disclosed herein, but do not comprise all or a portion of any intron. In another embodiment, the polynucleotides comprising coding sequences do not contain coding sequences of a genomic flanking gene (i.e., 5′ or 3′ to the gene of interest in the genome). In other embodiments, the polynucleotides of the invention do not contain the coding sequence of more than 1000, 500, 250, 100, 50, 25, 20, 15, 10, 5, 4, 3, 2, or 1 genomic flanking gene(s).

[0069] A “polynucleotide” of the present invention also includes those polynucleotides capable of hybridizing, under stringent hybridization conditions, to sequences contained in SEQ ID NO: X, or the complement thereof (e.g., the complement of any one, two, three, four, or more of the polynucleotide fragments described herein), the polynucleotide sequence delineated in columns 8 and 9 of Table 2 or the complement thereof, and/or cDNA sequences contained in Clone ID NO: Z (e.g., the complement of any one, two, three, four, or more of the polynucleotide fragments, or the cDNA clone within the pool of cDNA clones deposited with the ATCC, described herein) and/or the polynucleotide sequence delineated in column 6 of Table 1B or the complement thereof. “Stringent hybridization conditions” refers to an overnight incubation at 42 degree C. in a solution comprising 50% formamide, 5×SSC (750 mM NaCl, 75 mM trisodium citrate), 50 mM sodium phosphate (pH 7.6), 5×Denhardt's solution, 10% dextran sulfate, and 20 μg/ml denatured, sheared salmon sperm DNA, followed by washing the filters in 0.1×SSC at about 65 degree C.

[0070] Also contemplated are nucleic acid molecules that hybridize to the polynucleotides of the present invention at lower stringency hybridization conditions. Changes in the stringency of hybridization and signal detection are primarily accomplished through the manipulation of formamide concentration (lower percentages of formamide result in lowered stringency), salt conditions, or temperature. For example, lower stringency conditions include an overnight incubation at 37 degree C. in a solution comprising 6×SSPE (20×SSPE=3M NaCl; 0.2M NaH₂PO₄; 0.02M EDTA, pH 7.4), 0.5% SDS, 30% formamide, 100 ug/ml salmon sperm blocking DNA; followed by washes at 50 degree C. with 1×SSPE, 0.1% SDS. In addition, to achieve even lower stringency, washes performed following stringent hybridization can be done at higher salt concentrations (e.g. 5×SSC).

[0071] Note that variations in the above conditions may be accomplished through the inclusion and/or substitution of alternate blocking reagents used to suppress background in hybridization experiments. Typical blocking reagents include Denhardt's reagent, BLOTTO, heparin, denatured salmon sperm DNA, and commercially available proprietary formulations. The inclusion of specific blocking reagents may require modification of the hybridization conditions described above, due to problems with compatibility.

[0072] Of course, a polynucleotide which hybridizes only to polyA+ sequences (such as any 3′ terminal polyA+ tract of a cDNA shown in the sequence listing), or to a complementary stretch of T (or U) residues, would not be included in the definition of “polynucleotide,” since such a polynucleotide would hybridize to any nucleic acid molecule containing a poly (A) stretch or the complement thereof (e.g., practically any double-stranded cDNA clone generated using oligo dT as a primer).

[0073] The polynucleotide of the present invention can be composed of any polyribonucleotide or polydeoxribonucleotide, which may be unmodified RNA or DNA or modified RNA or DNA. For example, polynucleotides can be composed of single- and double-stranded DNA, DNA that is a mixture of single- and double-stranded regions, single- and double-stranded RNA, and RNA that is mixture of single- and double-stranded regions, hybrid molecules comprising DNA and RNA that may be single-stranded or, more typically, double-stranded or a mixture of single- and double-stranded regions. In addition, the polynucleotide can be composed of triple-stranded regions comprising RNA or DNA or both RNA and DNA. A polynucleotide may also contain one or more modified bases or DNA or RNA backbones modified for stability or for other reasons. “Modified” bases include, for example, tritylated bases and unusual bases such as inosine. A variety of modifications can be made to DNA and RNA; thus, “polynucleotide” embraces chemically, enzymatically, or metabolically modified forms.

[0074] The polypeptide of the present invention can be composed of amino acids joined to each other by peptide bonds or modified peptide bonds, i.e., peptide isosteres, and may contain amino acids other than the 20 gene-encoded amino acids. The polypeptides may be modified by either natural processes, such as posttranslational processing, or by chemical modification techniques which are well known in the art. Such modifications are well described in basic texts and in more detailed monographs, as well as in a voluminous research literature. Modifications can occur anywhere in a polypeptide, including the peptide backbone, the amino acid side-chains and the amino or carboxyl termini. It will be appreciated that the same type of modification may be present in the same or varying degrees at several sites in a given polypeptide. Also, a given polypeptide may contain many types of modifications. Polypeptides may be branched, for example, as a result of ubiquitination, and they may be cyclic, with or without branching. Cyclic, branched, and branched cyclic polypeptides may result from posttranslation natural processes or may be made by synthetic methods. Modifications include acetylation, acylation, ADP-ribosylation, amidation, covalent attachment of flavin, covalent attachment of a heme moiety, covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent attachment of phosphotidylinositol, cross-linking, cyclization, disulfide bond formation, demethylation, formation of covalent cross-links, formation of cysteine, formation of pyroglutamate, formylation, gamma-carboxylation, glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, pegylation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer-RNA mediated addition of amino acids to proteins such as arginylation, and ubiquitination. (See, for instance, PROTEINS—STRUCTURE AND MOLECULAR PROPERTIES, 2nd Ed., T. E. Creighton, W. H. Freeman and Company, New York (1993); POSTTRANSLATIONAL COVALENT MODIFICATION OF PROTEINS, B. C. Johnson, Ed., Academic Press, New York, pgs. 1-12 (1983); Seifter et al., Meth. Enzymol. 182:626-646 (1990); Rattan et al., Ann. N.Y. Acad. Sci. 663:48-62 (1992).)

[0075] “SEQ ID NO: X” refers to a polynucleotide sequence described, for example, in Tables 1A or 2, while “SEQ ID NO: Y” refers to a polypeptide sequence described in column 5 of Table 1A. SEQ ID NO: X is identified by an integer specified in column 3 of Table 1A. The polypeptide sequence SEQ ID NO: Y is a translated open reading frame (ORF) encoded by polynucleotide SEQ ID NO: X. “Clone ID NO: Z” refers to a cDNA clone described in column 1 of Table 1A.

[0076] “A polypeptide having biological activity” refers to a polypeptide exhibiting activity similar to, but not necessarily identical to, an activity of a polypeptide of the present invention, including mature forms, as measured in a particular biological assay, with or without dose dependency. In the case where dose dependency does exist, it need not be identical to that of the polypeptide, but rather substantially similar to the dose-dependence in a given activity as compared to the polypeptide of the present invention (i.e., the candidate polypeptide will exhibit greater activity or not more than about 25-fold less and, preferably, not more than about tenfold less activity, and most preferably, not more than about three-fold less activity relative to the polypeptide of the present invention).

[0077] Table 1A summarizes some of the reproductive system associated polynucleotides encompassed by the invention (including contig sequences (SEQ ID NO: X) and clones (Clone ID NO: Z) and further summarizes certain characteristics of these polynucleotides and the polypeptides encoded thereby.

[0078] Polynucleotides and Polypeptides TABLE 1A AA Tissue Distribution SEQ Library code: count OMIM Clone ID Contig SEQ ID ORF ID (see Table IV for Cytologic Disease NO: Z ID: NO: X (From-To) NO: Y Predicted Epitopes Library Codes) Band Reference(s): H7MCE35 928554 11 71-3  2698 S0286: 1 and S0284: 1. H7MDC49 722780 12 125-3  2699 S0284: 2 and L0758: 1. H7MDD72 847688 13 100-510 2700 Glu-9 to Gly-22, AR054: 6, AR050: 2, Lys-50 to Lys-69, AR051: 1, AR089: 1, Gly-91 to Arg-107, AR061: 0 Pro-113 to Ile-129, S0284: 2 Tyr-131 to Gln-137. 887805 2651  3-824 5338 HAOSH55 952380 14  2-355 2701 Pro-17 to Glu-28, L0770: 3, H0686: 1, Gly-86 to Ser-92. H0634: 1, L0761: 1, L0772: 1, L0764: 1, L0805: 1, L0786: 1 and L0779: 1. HAQAK73 764671 15 449-661 2702 Glu-16 to Pro-21, H0295: 2 and L0748: 2. Leu-28 to Asp-34, Glu-39 to Ser-56, Glu-59 to Gly-67. HAQAM17 664979 16  1-198 2703 H0295: 1 and H0435: 1. HAQBF84 783259 17  2-70 2704 H0295: 2 HAQBJ71 839982 18  17-367 2705 Ala-55 to Phe-72. H0295: 3 and H0294: 1. HAQBQ50 522004 19  3-59 2706 H0295: 2 HAQBS37 847519 20 159-437 2707 H0295: 2, L0649: 1, L0663: 1, H0435: 1 and H0670: 1. HAUBD69 529711 21  3-134 2708 H0294: 2 and H0435: 1. HAUBU10 968339 22 209-337 2709 H0294: 2 HBCJS08 957826 23 228-374 2710 Val-17 to Thr-27. H0664: 2 HBCPD14 963634 24  15-140 2711 H0663: 1 and S0152: 1. HBCQJ03 922401 25 138-1  2712 Arg-1 to Trp-15. H0663: 2 HBCQS90 951787 26  3-317 2713 Glu-24 to Lys-29, H0663: 2, L0758: 2, Lys-35 to Gln-40. L0748: 1 and L0591: 1. HBCQS93 930682 27 390-575 2714 Gly-1 to Gly-6, L0749: 2, H0663: 1, Gly-41 to Pro-46. H0662: 1 and L0438: 1. HBGBD28 525846 28  3-185 2715 Asn-37 to Gly-44. H0181: 2 HBGBF56 957870 29  2-184 2716 Pro-31 to Glu-36. H0181: 1 and H0617: 1. HBGBG42 922396 30  1-420 2717 H0662: 2, H0181: 2, L0766: 2, L0455: 1, L0740: 1, L0779: 1 and L0362: 1. HBGBH43 524532 31  1-195 2718 H0553: 2, H0181: 2, L0743: 2, L0639: 1, L0787: 1, L0790: 1, L0747: 1, L0780: 1, L0752: 1 and L0755: 1. HBGBS07 954299 32  1-324 2719 Val-57 to Leu-66, H0181: 2 1q21 104770, Val-79 to Gly-84. 107670, 110700, 135940, 145001, 146790, 152445, 152445, 159001, 174000, 179755, 182860, 182860, 182860, 191315, 230800, 230800, 266200, 600897, 601105, 601412, 601652, 602491 HBGBT79 525352 33 109-306 2720 Arg-7 to Trp-17. H0181: 2 HBGBW60 954916 34  52-492 2721 H0617: 2 and H0181: 1. HBGBW72 524956 35  31-156 2722 Glu-1 to Gly-9. H0181: 2 and H0617: 1. HBGDA44 525618 36 163-507 2723 Thr-1 to Pro-6. H0181: 2 HBGDE85 524875 37  1-132 2724 Pro-6 to Leu-12. H0181: 2 HBGDS13 971696 38 122-259 2725 H0181: 1 and H0617: 1. HBGDT43 974223 39  2-220 2726 Trp-8 to Gln-20. H0181: 3 HBGFA62 954306 40  3-302 2727 Gln-19 to Glu-24, L0040: 1, H0188: 1, Arg-29 to Pro-35, H0606: 1, L0762: 1, Ser-47 to Ser-56, L0803: 1, L0774: 1 and Pro-58 to Ser-64. L0509: 1. HBGMD05 870189 41 266-589 2728 Thr-1 to Ser-6, H0617: 2 Thr-23 to Pro-30. HBGMD62 933763 42  84-329 2729 Leu-36 to Asn-42. H0617: 3 HBGMF10 966132 43 162-434 2730 Pro-13 to Ser-19, L0764: 2, L0783: 2, Pro-60 to Ala-76, H0182: 1, H0617: 1, Asp-78 to Gly-85. H0616: 1, L0765: 1, L0375: 1, L0659: 1, L0809: 1, L0663: 1, L0731: 1 and L0361: 1. HBGMG29 845194 44  22-279 2731 Arg-71 to Arg-76. H0617: 2 HBGMZ39 947112 45 575-3  2732 Arg-37 to Phe-48, AR089: 15, AR061: 10 Asp-55 to Asp-63, H0617: 8, L0763: 2, Gly-73 to Ala-80, L0754: 2, H0483: 1 and Gln-147 to Trp-154, L0743: 1. Val-176 to Lys-191. HBGNA08 958257 46  82-162 2733 H0617: 2 HBGND09 848219 47  1-522 2734 Gly-1 to Arg-8, H0617: 2, L0758: 2, Gly-17 to Vla-25, H0181: 1, L0521: 1, Gln-27 to Gln-32, L0661: 1 and L0779: 1. Ala-56 to Gly-64, Glu-121 to Thr-129, Arg-156 to Asp-174. HBGNJ14 914594 48  1-330 2735 Gly-3 to Thr-15, H0617: 3 Pro-49 to Ser-54, Pro-56 to His-63, Gly-81 to Pro-87, Pro-92 to Thr-98. HBGNM13 912730 49  12-197 2736 H0617: 2 HBGNO07 952212 50  2-358 2737 Glu-14 to Cys-20, H0181: 1 and H0617: 1. Glu-22 to His-32, Asp-39 to Thr-52, Lys-92 to Asp-101. HBGNQ31 887152 51  2-268 2738 Cys-7 to Gly-12, AR054: 129, AR051: Ser-19 to Thr-26, 118, AR050: 110 Ala-31 to Leu-36, H0617: 4 and L0770: 2. Ser-47 to Ser-57, Glu-75 to Phe-83. HBGNW29 969396 52  24-263 2739 Gly-58 to Pro-69. H0617: 2, H0663: 1 and H0181: 1. HBGOB07 883111 53  10-420 2740 Thr-21 to Lys-27, H0617: 2, L0439: 2, Cys-33 to Pro-38, L0771: 1, L0766: 1, Lys-68 to Trp-103, L0779: 1 and L0752: 1. Pro-118 to Val-124, Pro-129 to Lys-137. HBGOJ28 967261 54 195-599 2741 Leu-30 to Thr-56, H0617: 2 Arg-61 to Thr-71. HBGOK53 848156 55  13-278 2742 H0617: 2 HBGOL08 958290 56  1-369 2743 L0041: 2, H0617: 2, L0659: 1, L0438: 1 and L0601: 1. HBGPE04 926876 57  1-219 2744 Gly-22 to Ala-31, H0617: 2 Arg-58 to Trp-73. HBGPH02 918513 58 158-340 2745 Leu-14 to Pro-20, H0617: 2, L0780: 1, Ser-49 to Ile-55. L0752: 1 and L0594: 1. HBGPK33 973425 59  14-274 2746 H0617: 4 HBGPV05 930706 60  2-205 2747 Pro-13 to Arg-26. H0617: 3 HBGQG66 954302 61  1-309 2748 Met-3 to Asn-8, H0181: 1 and H0617: 1. Ala-11 to Pro-39. HBGSD40 923142 62  3-413 2749 Arg-4 to His-10, L0777: 3, H0617: 2, Pro-14 to Thr-20, L0731: 2, H0606: 1, Glu-28 to Arg-35, L0769: 1, L0803: 1, Thr-40 to Ser-56, L0743: 1, L0744: 1, Thr-61 to Ser-75, L0750: 1 and L0779: 1. Pro-93 to Arg-102, Asp-118 to Arg-124. HBGTK11 965509 63  1-273 2750 Pro-70 to Arg-78. H0617: 3 HBGTL01 914573 64  13-561 2751 Pro-28 to Trp-34. L0794: 3, H0617: 2, L0750: 1 and L0758: 1. HBGTR84 886529 65  3-581 2752 Asp-43 to Arg-49, AR051: 23, AR050: 17, Glu-55 to Asp-64, AR054: 16 Glu-75 to Arg-81, H0617: 4 Leu-89 to Gly-98, Leu-110 to Lys-115, Asn-131 to Thr-141, Asn-152 to Lys-160. HBNAB01 966536 66  1-138 2753 Ser-8 to Leu-20. H0253: 1 and H0188: 1. 17p13.1 191170, 191170 HBNAF14 660800 67  86-271 2754 H0618: 1 and H0188: 1. HBNAI17 655514 68  1-231 2755 H0188: 2 HBNAN41 655842 69 123-302 2756 Asn-3 to Ser-15, H0188: 2 Lys-21 to Asn-30. HBNAW92 524954 70  2-226 2757 Gly-21 to Pro-27. H0188: 2 HBNAX71 530843 71  1-87 2758 H0188: 2 HBNAY58 558193 72 245-400 2759 Leu-14 to Thr-20. H0188: 2 and L0603: 1. HBNBT52 524869 73 201-380 2760 Gln-48 to Pro-56. H0188: 2 HBZAJ09 655769 74  1-330 2761 Phe-13 to Phe-18, S0188: 2 Gly-23 to Arg-38. HBZSH16 655619 75  93-212 2762 Ser-1 to Ser-11. S0190: 2 HBZSH71 760418 76 116-301 2763 Thr-29 to Arg-34. S0190: 2 HBZSI73 655737 77  2-352 2764 S0190: 2 HBZSK17 664013 78 111-383 3765 Val-3 to Lys-9. H0059: 1 and S0190: 1. 22q11.2-q13.2 123620, 138720, 145410, 188826, 231950, 239500, 275350, 600850 HCBMV01 914333 79 322-119 2766 Ser-1 to Met-6. H0661: 1 and H0553: 1. HCBNW02 950897 80 183-521 2767 H0661: 2 HCBNW07 951820 81  8-130 2768 Lys-28 to Phe-34. L0770: 3, L0776: 3, H0686: 1, H0661: 1, L0021: 1, L0761: 1, L0766: 1, L0659: 1, L0647: 1, L0752: 1 and L0605: 1. HCBOG03 922351 82  2-283 2769 Lys-33 to Arg-38. H0661: 2 HCDMB01 915613 83  3-125 2770 S0398: 2 HCDMB16 835781 84  2-181 2771 S0398: 2 HCDMB60 726339 85  22-120 2772 Thr-6 to Leu-12, S0398: 2 Tyr-19 to Lys-28. HCDMC01 915239 86  2-901 2773 Ser-10 to Gly-23. L0758: 13, H0253: 4, H0618: 3, H0038: 1, L0779: 1 and S0398: 1. HCDMD23 676799 87  2-184 2774 S0398: 2 HCHAD40 923764 88  78-269 2775 Lys-29 to Arg-34. H0483: 2 13 HCHAR16 675465 89  3-134 2776 Cys-1 to Pro-10, H0483: 2 Thr-19 to Glu-28, Arg-36 to Asn-44. HCHAR43 715128 90  1-366 2777 Ser-24 to Gly-29, H0483: 2 Xp22.3 300077, Asn-47 to Pro-53, 300500, Pro-74 to Gly-79. 300650, 301200, 302350, 302950, 308700, 311200, 312040 HCHAR67 665184 91  1-318 2778 Phe-24 to Gln-30, H0483: 1 and H0550: 1. Gln-32 to Leu-42. HCHBQ03 923763 92 190-459 2779 Asp-1 to Phe-21. H0483: 4 and H0484: 1. 13 HCHML32 668518 93  35-343 2780 H0484: 2 HCHND96 880585 94 144-455 2781 Glu-13 to Ser-21, H0616: 7, L0758: 5, Asp-67 to Asp-73. H0484: 1, H0040: 1, L0768: 1, L0774: 1 and L0775: 1. HCHOA76 740102 95  1-321 2782 Leu-26 to Cys-39, H0484: 2 Cys-41 to Lys-50, Gly-87 to Glu-93. HCHOD89 954866 96  2-214 2783 Glu-11 to Gly-17, H0484: 1 and H0483: 1. Arg-25 to Ser-36. HCHPO55 717671 97  1-129 2784 Gly-1 to Gly-14. H0484: 1 and H0483: 1. HCHQB06 934941 98  3-455 2785 Pro-13 to Gly-20, H0484: 2, L0803: 1 Ser-29 to Ala-45, and L0758: 1. Ser-66 to Ala-72, Phe-74 to Trp-87, Pro-102 to Arg-107. HCMSE07 927904 99 522-896 2786 Ala-2 to Lys-10, AR089: 42, AR061: 34 Glu-70 to Glu-76. H0651: 154, L0731: 9, L0777: 6, L0803: 4, L0775: 3, H0196: 2, H0163: 2, L0662: 2, L0805: 2, L0783: 2, L0438: 2, L0740: 2, L0759: 2, H0170: 1, S0444: 1, H0592: 1, H0632: 1, L0471: 1, H0399: 1, H0615: 1, H0040: 1, S0294: 1, H0647: 1, L0598: 1, L0763: 1, L0638: 1, L0637: 1, L0642: 1, L0374: 1, L0767: 1, L0768: 1, L0794: 1, L0804: 1, L0774: 1, L0375: 1, L0776: 1, L0606: 1, L0659: 1, L0809: 1, L0647: 1, L0789: 1, L0791: 1, L0666: 1, L0663: 1, L0664: 1, L0665: 1, H0659: 1, H0658: 1, H0672: 1, S0328: 1, H0539: 1, S0380: 1, L0439: 1, L0779: 1, L0594: 1, L0361: 1, S0026: 1, S0242: 1 and S0460: 1. HCOMZ41 932878 100 120-296 2787 Arg-1 to Pro-10, L0768: 2, H0150: 1 Ile-21 to Gly-34. and H0670: 1. HCOOG04 925748 101 68-3  788 Tyr-10 to Cys-17. H0670: 2 HCOOI07 951665 102  75-458 2789 Ser-40 to Gly-45, H0670: 2 Pro-55 to Asp-67. HCOOM77 969161 103  83-283 2790 H0670: 2 HCOOX10 961595 104  1-471 2791 Val-19 to Trp-24, H0059: 1, L0803: 1 Lys-70 to Lys-78, and H0670: 1. Ser-83 to Leu-100, Val-112 to Trp-117, Thr-119 to Lys-125, Cys-133 to Pro-143. HCOOZ11 965306 105  89-592 2792 Asp-43 to Glu-48. AR089: 15, AR061: 5 22q13.1-q13.2 103050, H0662: 2, H0670: 1, 103050, L0756: 1 and L0759: 1. 124030, 124030, 138981, 182380, 188826, 190040, 190040, 190040 HCOPP18 954332 106 259-585 2793 Gly-11 to Ser-16. H0169: 2, L0809: 1, H0670: 1 and L0599: 1, HCOQE11 965299 107 409-684 2794 Gln-20 to Tyr-25, H0670: 4, L0776: 2, Asp-73 to Ser-79. L0666: 2, L0759: 2, H0661: 1, L0717: 1, L0664: 1, L0779: 1, L0777: 1, L0752: 1 and L0755: 1. HCOQH12 969151 108 292-564 2795 Ala-52 to Lys-58, H0670: 2 and L0366: 1. Gly-72 to Arg-79. HCOQQ07 951658 109 187-429 2796 H0670: 2 HE8SG46 961388 110 1335-1553 2797 Glu-40 to Asn-46. H0683: 122, L0740: 6, L0747: 5, L0438: 4, L0439: 4, L0756: 3, H0156: 2, L0521: 2, H0658: 2, L0754: 2, L0750: 2, L0779: 2, L0777: 2, L0731: 2, L0759: 2, H0171: 1, H0486: 1, H0244: 1, H0427: 1, H0310: 1, H0052: 1, H0263: 1, H0596: 1, L0163: 1, H0051: 1, H0328: 1, S0112: 1, L0768: 1, L0803: 1, L0774: 1, L0527: 1, L0517: 1, L0783: 1, L0666: 1, L0663: 1, H0670: 1, H0648: 1, S0152: 1, S0146: 1, H0478: 1, L0752: 1, L0758: 1 and S0412: 1. HEAAA42 963100 111  3-272 2798 AR061: 8, AR089: 5 H0038: 4, H0616: 3, L0747: 3, L0663: 2, L0758: 2, H0369: 1, H0428: 1, L0769: 1, L0542: 1, L0809: 1, L0666: 1, L0665: 1, L0743: 1, L0777: 1, L0731: 1 and S0456: 1. HEAAB77 574510 112  1-360 2799 Glu-7 to Arg-24. H0369: 2 HEAAK46 574232 113  69-188 2800 His-33 to Val-39. H0369: 2 and H0664: 1. HEAAM16 574008 114 114-221 2801 H0369: 2 HEAAM52 960579 115  2-154 2802 H0369: 1 and H0040: 1. HEAAN18 932383 116  78-227 2803 H0369: 2 HEAAQ66 653242 117 168-401 2804 H0369: 2 HEAAT36 531348 118 114-488 2805 Phe-71 to Gln-78, L0748: 3, H0369: 1 Lys-87 to His-95. and H0031: 1. HEAAT60 733632 119 121-471 2806 Gly-12 to Ile-18. H0369: 2 HEAAV10 968200 120  99-236 2807 H0369: 2 HEAAV33 574508 121 219-449 2808 Asp-25 to Glu-30, H0369: 2 and L0747: 1. Leu-39 to Val-48. HEDAE67 752875 122  1-147 2809 Ser-5 to Tyr-19, H0534: 4 and H0533: 3. Arg-22 to Thr-32. HEEAD64 741305 123  1-159 2810 Glu-21 to Lys-30, H0549: 2 Gly-33 to Ser-39. HEEAH07 851219 124  1-150 2811 Pro-44 to Phe-50. H0549: 2 HEEAJ58 785121 125 246-1  2812 Lys-25 to Gly-34, H0549: 2 Pro-42 to Trp-57. Lys-71 to Asp-82. HEEAJ76 887321 126  3-332 2813 AR054: 10, AR051: 9, AR050: 8 H0549: 2 HEEAK22 673904 127 140-253 2814 Gly-24 to Leu-30. H0549: 2 HEEAK84 780838 128 167-283 2815 Glu-12 to Gln-19. H0549: 2 HEEAL31 887312 129  3-203 2816 Val-19 to Ser-25, H0369: 2 and H0549: 2. Arg-39 to Ser-60. HEEAN24 676721 130  1-147 2817 H0549: 2 HEEAS58 735620 131  3-278 2818 Ala-76 to Gly-84. H0549: 2 HEEAU79 706935 132  1-228 2819 Ala-17 to Gly-30, H0549: 2 and L0600:1. Arg-39 to Trp-46. HEEAW01 851213 133  55-195 2820 Lys-12 to Trp-17. H0549: 2 HEEAW13 656299 134  28-168 2821 Phe-27 to Trp-32. H0549: 2 HEGAA24 676716 135  1-204 2822 Gly-1 to Glu-10, H0550: 2 Gly-41 to Val-47. HEGAA73 767284 136 150-425 2823 Ser-52 to Trp-58. H0550: 2 HEGAB84 823900 137  1-351 2824 Ile-30 to Gly-36, AR089: 13, AR061: 8 Thr-67 to Thr-72. H0618: 2 and H0550: 1. HEGAC69 754344 138 281-475 2825 Ser-48 to Lys-54. H0550: 2 and L0750: 1. HEGAC95 965183 139 113-355 2826 H0550: 1 and H0328:1. HEGAI82 955291 140  1-330 2827 Ala-51 to Glu-60, H0550: 1, H0644: 1 Pro-88 to Ser-104. and L0659: 1. HEGAK04 887299 141  54-305 2828 Ala-29 to Lys-51, AR054: 16, AR051: 5, Arg-69 to His-75. AR050: 3 H0550: 2 and L0749: 1. HEGAO83 780837 142  3-326 2829 Lys-1 to Ser-52. AR089: 9, AR061: 7 H0550: 1 and H0253: 1. HEGAP06 934705 143  3-254 2830 Asn-4 to Asn-10, L0754: 4, L0776: 2, Gly-14 to Asp-21, L0743: 2, L0750: 2, Leu-26 to Gly-39. L0779: 2, H0550: 1, L0769: 1 and H0658: 1. HEGAP31 697419 144  59-319 2831 Gly-1 to Gly-10, H0550: 2 Glu-46 to Ser-52, Pro-61 to Pro-67, Arg-69 to Asp-75, Ser-82 to Ser-87. HEGAP36 706951 145 117-239 2832 Tyr-36 to Thr-41. H0550: 2 HEGAR53 719387 146 462-644 2833 Val-1 to Leu-6, H0550: 1, H0212: 1, Arg-13 to Phe-18. L0745: 1 and L0746: 1. HEGAY32 699906 147  1-195 2834 Leu-22 to Ser-28, H0550: 2 Lys-36 to Lys-43, His-56 to Pro-65. HEGAY52 726316 148  1-204 2835 His-32 to Trp-37, H0550: 2 Pro-39 to Thr-53. HEGAZ61 950033 149  12-560 2836 Leu-45 to Lys-50, AR050: 66, AR054: 55, Gln-55 to Glu-74, AR051: 37, AR089: 11, Thr-114 to Ile-119. AR061: 6 H0549: 1 and H0550: 1. HEPAA44 509456 150  91-204 2837 Ala-6 to Gln-12. H0150: 2 HEPAB70 557149 151  90-353 2838 Ser-7 to Asp-20, H0150: 2 Thr-30 to Phe-41, Gly-55 to Gly-61. HEPAD09 888726 152  3-176 2839 Ala-20 to Gln-36, AR050: 154, AR051: 16q24.3 155555, Pro-38 to Asn-50. 146, AR054: 141 155555, H0150: 3 227650, 253000, 602783 HEPAD40 509002 153 132-257 2840 H0150: 2 HEPAD82 509452 154  3-113 2841 Ile-14 to Leu-22. H0150: 3 and L0763: 1. HEPAJ70 586843 155  1-75 2842 His-1 to Thr-9. H0150: 2 9q34.2-q34.3 120215, 120215, 190198 HEPAK01 518331 156  73-309 2843 Asn-1 to Lys-7, H0150: 2 Leu-27 to His-32, Arg-34 to Pro-50. HEPAK41 925146 157 284-583 2844 Pro-4 to Arg-13, H0549: 1, H0150: 1, Val-34 to Asp-40. L0761: 1 and L0764: 1. HEPAM29 508706 158  2-154 2845 Ser-9 to Leu-20, H0150: 2 Thr-38 to Thr-44. HEPAN19 508694 159 250-360 2846 Leu-13 to Lys-21. L0758; 3, H0150: 2, L0803: 1 and L0779: 1. HEPAP02 926914 160  3-167 2847 H0150: 2 2p12 147200, 178640, 216900 HEPAP12 968771 161 105-284 2848 H0150: 2 HEPAS44 884083 162  3-260 2849 H0150: 2, L0369: 1 and L0532: 1. HEPBA39 919875 163  3-518 2850 His-1 to Met-10. AR061: 44, AR089: 13 H0150: 10, H0549: 5, H0176: 1, L0790: 1 and L0779: 1. HEPBB24 508684 164  42-179 2851 H0150: 3 HEPBB60 855597 165  72-323 2852 H0150: 4 HEPBG26 967921 166  4-204 2853 H0150: 2 HEPBG35 508686 167  92-229 2854 Asp-15 to Gly-21, H0150: 1 and L0717: 1. Gln-32 to Lys-45. HEPBH28 508673 168 171-290 2855 Glu-7 to Gln-12. H0150: 2, L0809: 1, L0731: 1 and L0758: 1. HEPBH38 707524 169  99-257 2856 H0150: 2 HEPBH45 508696 170 193-312 2857 H0150: 3 HEPBO69 888697 171 112-216 2858 H0150: 5 HEPBQ47 713836 172  91-291 2859 Pro-4 to Ser-12. H0150: 2 HEPBQ69 888693 173 272-460 2860 His-25 to Ile-31. AR050: 7, AR054: 1 H0150: 3 HEPBS10 968665 174 123-296 2861 Ala-1 to Asp-7. H0150: 2 HEPBX43 715685 175  2-445 2862 Pro-12 to Gly-22. H0549: 2 and H0150: 2. HEPCD36 523670 176  37-297 2863 Asp-18 to Thr-28. H0150: 2 and H0165: 1. HEPCE25 529343 177  2-121 2864 H0150: 2 HEPCO59 761094 178  19-117 2865 H0150: 2 HEPCT32 947081 179 227-685 2866 Ser-20 to Lys-30, AR051: 15, AR054: 2, Ala-43 to Ser-45, AR050: 0 Ser-65 to Thr-72, H0150: 4, H0038: 3, Thr-112 to Thr-118, L0758: 3 and L0779: 2. Ala-139 to Arg-147. HEPCU32 931824 180 448-975 2867 Arg-57 to Arg-64, AR051: 9, AR054: 8, Arg-106 to Arg-116, AR050: 1, AR061: 0, Gln-128 to Pro-135. AR089: 0 H0150: 2, H0270: 1, H0032: 1, H0212: 1 and L0779: 1. 946975 2652 345-872 5339 Arg-57 to Arg-64, Arg-106 to Arg-116, Gln-128 to Pro-135. HEQAE65 911438 181  2-160 2868 Pro-11 to Gly-16, AR089: 1, AR061: 0 Gln-37 to Gln-43. H0544: 1 and H0435: 1. HEQAH70 699690 182  1-186 2869 H0544: 1 and H0038: 1. 5p13 108962 120940, 217050, 217050, 217070, 245050, 600837, 600946, 600946, 600946 HEQAO76 769973 183  86-436 2870 Ser-3 to Phe-65, H0544: 2 7 Glu-78 tp Ala-91, Ala-95 to Ser-116. HEQAZ52 727051 184  10-180 2871 H0544: 2 and L0748: 2. HEQBA41 712243 185  80-529 2872 Pro-1 to Glu-15, H0544: 1 and H0038: 1. Pro-29 to Val-35. HETAD29 509311 186  3-89 2873 Asn-13 to Cys-19. H0046: 2 HETAF20 509308 187  61-273 2874 Pro-22 to Gln-32. H0046: 3 HETAF49 509306 188  63-362 2875 Lys-1 to Val-24, H0046: 2 and L0748:2. Val-27 to Leu-32. HETAF89 509300 189  3-248 2876 H0046: 2 HETAH16 942612 190  1-348 2877 Asn-1 to Gly-13, H0046: 3 Val-23 to Ser-28, Ala-52 to Thr-63, Asp-75 to Thr-80. HETAH66 799665 191 161-364 2878 Lys-14 to Pro-22. H0046: 6 HETAH67 535390 192 128-226 2879 H0046: 4 HETAJ26 508994 193  3-164 2880 Ser-20 to Pro-25. H0046: 2 HETAK75 518156 194  3-290 2881 H0046: 2 HETAN20 535359 195  2-202 2882 H0046: 4 HETAP59 509118 196 162-305 2883 Gln-15 to Ser-21. H0046: 3 HETAP94 960392 197  17-136 2884 Pro-13 to Gln-22, H0046: 5 Arg-24 to Cys-30, Thr-35 to Lys-40. HETAR06 960839 198  2-313 2885 Ile-18 to Gln-23, H0046: 3 Ser-36 to Ser-41. HETAR60 934444 199  1-162 2886 H0046: 3 HETAT83 918730 200 634-801 2887 H0046: 58 and H0616: 1. HETAZ13 536192 201 156-275 2888 Arg-35 to Glu-40. H0046: 1 and S0004: 1. HETBA01 509189 202  33-203 2889 H0046: 2 HETBF45 508655 203  1-138 2890 H0046: 2 HETBH48 720853 204  81-257 2891 Asp-11 to Gln-18, H0046: 3 Pro-38 to Ser-43. HETBR25 509099 205  3-311 2892 Phe-1 to Ser-6, H0046: 2 andL0741: 1. Arg-26 to Lys-31, Arg-54 to Ser-59. HETBW39 523046 206  3-125 2893 Thr-3 to Thr-9, H0046: 2 Ala-24 to Cys-29. HETCE12 971505 207 354-647 2894 H0046: 5, L0748: 2 and L0527: 1. HETCE55 508666 208 143-307 2895 Gly-20 to Gly-27. H0046: 3 and L0748: 1. HETCG63 841924 209  542-1249 2896 Asn-1 to Ile-20, H0046: 68, S0013: 2, Tyr-29 to Lys-41, H0369: 1, H0431: 1, Thr-68 to Gln-74, H0013: 1, H0156: 1 and Asp-88 to Tyr-101, S0014: 1. Lys-108 to Cys-116, Thr-136 to Thr-145, Thr-158 to Cys-171, Ser-183 to Pro-188. HETCH92 921390 210 121-204 2897 H0046: 2 HETCL55 522829 211  31-201 2898 Ala-32 to Pro-57. H0046: 2 HETDA81 525412 212 119-361 2899 Thr-56 to Pro-62, H0046: 2 and H0648: 1. Asp-76 to Gly-81. HETDD18 509110 213 149-283 2900 His-3 to Asn-10. H0046: 3 HETDE67 883018 214 107-364 2901 Lys-25 to Asn-35. H0046: 1 and H0615: 1. HETDE86 855509 215  54-398 2902 Tyr-1 to Ala-9. H0046: 3 and L0617: 1. 22q11.2 123620, 138720, 145410, 231950, 239500, 275350, 600850 HETDG67 960870 216 446-652 2903 H0046: 10 and S0152: 1. HETDI03 925489 217  1-159 2904 Asn-1 to Arg-14. H0046: 2 HETDL92 508990 218 146-274 2905 H0046: 2 HETDN90 695021 219 131-235 2906 Leu-1 to Ser-6. H0046: 2 HETDP21 525407 220 116-295 2907 H0031: 2 and H0046: 1. HETDT15 600714 221 191-397 2908 H0046: 2 and L0756: 1. HETDW59 827093 222 180-281 2909 H0046: 2 HETEB68 917400 223  39-248 2910 His-7 to Thr-22. H0046: 9 HETEQ16 952297 224  1-273 2911 Arg-1 to Ile-29. H0046: 5 HETEZ43 529591 225 189-359 2912 Asn-8 to Trp-15, H0046: 2 Xq26.1 300123, Leu-20 to Ser-32. 301201, 301845, 301900, 304340, 307150, 307700, 308000, 308000, 309000, 310490, 313850 HETFA40 523112 226 195-476 2913 Asn-1 to Asp-10, H0046: 3 Asp-25 to Gly-30, Asp-45 to Asp-56. HETFC82 799658 227  1-543 2914 H0046: 5 and L0665: 1. HETFE48 974351 228 283-510 2915 H0046: 14 HETFG29 795274 229 275-643 2916 Ala-22 to Tyr-27, H0046: 3, H0618: 1, Val-58 to Arg-75, H0038: 1 and H0616: 1. Ala-82 to Gly-88, Pro-97 to Gln-102, Val-109 to Asp-117. HETFI24 954104 230  430-1149 2917 Arg-1 to Lys-6, H0046: 53, H0616: 1 Glu-8 to Ser-15, and L0664: 1. Leu-17 to Leu-24, Gln-26 to Gln-46, Ala-58 to Gln-63, Gln-68 to Leu-74, Lys-82 to Arg-95, Glu-101 to Pro-107, Leu-139 to Lys-147, Glu-176 to Leu-186, Arg-208 to Ile-215. HETFI81 523398 231  66-239 2918 H0046: 2 HETFL39 973697 232 208-405 2919 Gln-42 to Gly-48. H0046: 2 HETFM43 973702 233  88-339 2920 Lys-6 to His-12, H0046: 9 Gly-20 to Gly-40, Gly-55 to Glu-69. HETGH30 527929 234  2-127 2921 Asn-9 to Gly-17. H0046: 2 HETGI40 505383 235  1-63 2922 Gly-6 to Asn-21. H0046: 2 HETGL62 523372 236  2-154 2923 H0046: 2 and L0771: 1. HETGL74 947978 237  3-581 2924 AR050: 47, AR051: 46, AR054: 39, AR089: 4, AR061: 2 H0046: 4 HETGN20 927789 238  7-567 2925 H0046: 2 and L0519: 2. HETGQ76 542486 239  23-190 2926 Pro-4 to Lys-11. H0046: 2 HETGD09 969632 240  11-109 2927 H0046: 2 HETHD30 935175 241 151-441 2928 Arg-1 to Pro-7, H0046: 9 Pro-13 to Ser-18, Ala-51 to Ser-64, Asn-92 to Lys-97. HETHE56 974348 242 101-259 2929 H0046: 4 HETHH49 967737 243 490-639 2930 H0046: 4 HETHO63 745503 244  90-428 2931 H0046: 1, H0032: 1 and L0740: 1. HETHO78 963592 245 475-660 2932 Ser-12 to Val-20. H0046: 5 HETHR24 851412 246  24-461 2933 Pro-1 to Arg-7, AR089: 1, AR061: 0 Thr-18 to Thr-29, H0046: 2 Arg-35 to Ser-50, His-87 to CyS-92. HETHT53 974555 247 302-439 2934 H0046: 3 HETIF01 966185 248  47-223 2935 H0046: 3 HETIG71 974359 249 262-411 2936 Ser-3 to Pro-10. H0046: 3 HETIJ84 766589 250  1-363 2937 Ala-60 to Lys-67, H0046: 14 Gln-71 to Gly-76. HETIJ85 883991 251  1-135 2938 Glu-7 to Glu-12. H0046: 2 HETIQ89 764951 252  81-245 2939 Ile-3 to His-12. H0046: 2 HETIU60 739804 253 458-646 2940 H0046: 3 HETIY84 935947 254  62-166 2941 Arg-16 to Asn-21. H0046: 2 HETJD30 974558 255 252-503 2942 Pro-49 to Thr-57. H0046: 18 HETJD86 909130 256  3-215 2943 Pro-14 to Pro-19, H0046: 5 and L0766: 1. Cys-3 to Ser-40. HETHG63 950017 257  94-462 2944 Val-10 to Asp-15. AR061: 4, AR089: 2 H0046: 2 and H0616: 1. HETJI32 806435 258 262-552 2945 L0375: 3, H0046: 2, L0774: 1 and L0789: 1. HETJK67 751072 259 173-433 2946 Ser-1 to Thr-7. H0046: 2 HETJN51 767932 260  26-274 2947 H0046: 2 HETJT95 789310 261 222-413 2948 Lys-8 to Thr-23. H0046: 3 HETJX04 927120 262  3-704 2949 Asp-11 to Val-21, AR089: 4, AR061: 2 Pro-27 to Thr-43, H0046: 1, H0032: 1, Trp-92 to Lys-97, H0040: 1 and L0565: 1. Pro-136 to Gly-149, Met-182 to Val-193, Thr-197 to Asn-203. HETJY11 966194 263 254-481 2950 H0046: 4 and L0774: 1. HETKA38 894600 264  3-308 2951 Val-50 to Arg-63, H0046: 3 and H0616: 1. Asp-75 to Trp-89, Pro-92 to Arg-98. HETKG67 974355 265 321-527 2952 H0046: 11 17 HETKH01 915320 266 20-226 2953 H0046: 3 HETKH92 790910 267  1-210 2954 Pro-1 to Gly-14, H0046: 2 Gly-17 to Ser-23, Ser-25 to Arg-34. HETKM55 974362 268  31-267 2955 Ser-12 to Arg-18, H0046: 17 Gln-69 to Met-74. HETKQ65 855449 269  3-353 2956 Leu-33 to His-38, H0046: 3 Pro-56 to Glu-61, Pro-11 to Leu-117. HETKV26 910030 270  2-664 2957 Asp-12 to Trp-20. AR061: 1, AR089: 0 H0046: 2 HETKX91 789797 271 150-254 2958 Leu-22 to Arg-28. H0046: 2 HETKZ65 941045 272  3-620 2959 Gln-1 to Glu-20. H0046: 2 HETLB04 920894 273  518-1333 2960 Glu-1 to Gly-6, H0046: 6 and H0616: 1. Val-21 to Asp-27. HETLH89 786458 274  2-250 2961 Cys-22 to Asp-27. H0046: 2 HETLM46 974361 275 111-314 2962 His-1 to Leu-8, H0046: 3 Lys-10 to Leu-17, Met-44 to Cys-49. HJMAE34 957079 276  3-305 2963 H0545: 2 HJMAZ84 919847 277  39-335 2964 H0545: 2 HJMBT23 858254 278 610-155 2965 Asp-53 to Gln-59, H0545: 2, L0766: 1, Asp-122 to Leu-128. L0775: 1, L0383: 1, L0742: 1 and L0747: 1. HLMNG77 675752 279 103-252 2966 Arg-11 to Ser-19. H0618: 6, L0758: 3, H0484: 1, H0255: 1, H0549: 1, H0253: 1, H0616: 1, L0794: 1, L0774: 1 and L0779: 1. HLWAB50 856552 280 167-367 2967 Tyr-23 to Ser-30. H0553: 2 HLWAD08 958554 281 146-295 2968 Asn-34 to Leu-40. H0553: 2, L0441: 1 and H0672: 1. HLWAG51 964389 282 588-989 2969 Ser-84 to Ile-92, L0754: 20, L0748: 10, Glu-104 to Gly-111. L0749: 10, H0553: 8, L0755: 8, H0031: 7, H0644: 6, H0030: 2, L0142: 1, L0771: 1, L0759: 1 and H0008: 1. HLWAH41 944774 283  13-771 2970 Arg-9 to Val-17, AR061: 2, AR089: 2 Pro-25 to Gly-30. L0748: 6, L0752: 5, H0553: 2, L0754: 2, L0749: 1 and L0780: 1. 948953 2653 687-286 5340 Gly-1 to Ser-6, Phe-12 to Trp-25, Ala-31 to Gly-42, Met-44 to Gln-49. HLWAI13 920690 284 158-376 2971 L0754: 2, H0553: 1, H0670: 1 and L0749: 1. HLWAJ64 746460 285 381-145 2972 H0553: 2 HLWAK69 694216 286 118-333 2973 Asn-12 to Ala-18, H0553: 1, H0435: 1 Gly-61 to Ser-70. and L0748: 1. HLWAK94 715727 287 330-175 2974 H0553: 2, L0536: 2, L0754: 2 and H0030: 1. HLWAR77 947484 288 1287-292  2975 Gln-97 to Pro-114, AR050: 21, AR054: 9, Trp-117 to Lys-129, AR051: 3, AR089: 1, Thr-166 to Gln-173, AR061: 1 Ser-178 to Lys-183, H0553: 4 and L0759: 2. Glu-250 to Phe-256, Ser-295 to His-301, Tyr-307 to Gln-316, Glu-322 to Ser-330. HLWAR78 723330 289 430-2  2976 Ser-20 to Gly-27, H0553: 2, H0030: 1 Gln-29 to Arg-41, and L0755: 1. Ser-46 to Pro-53. HLWAU18 666273 290  4-390 2977 Arg-112 to Ser-117. H0553: 2 HLWBA11 966796 291 192-350 2978 H0553: 2 HLWBA25 677944 292  1-192 2979 Lys-28 to Arg-39. H0553: 2, L0005: 1, L0143: 1, L0749: 1 and L0755: 1. HLWBE31 934562 293  1-150 2980 Val-2 to Pro-8, H0553: 2 Arg-21 to Trp-29, Thr-41 to Arg-50. HLWBE92 791362 294 252-1  2981 Leu-6 to Gln-11, H0030: 1 and H0553: 1. Arg-46 to Asp-52, Glu-68 to Pro-73. HLWBJ02 919639 295  90-380 2982 Ala-3 to Trp-10. H0553: 2 HLWBK40 711000 296  78-224 2983 H0553: 3 HLWBN49 713600 297  847-1067 2984 Arg-11 to His-20, L0748: 14, H0553: 4, Pro-23 to Gly-31. L0754: 4, H0644: 3, H0031: 2, L0005: 1, L0774: 1, S0454: 1, L0749: 1 and L0780: 1. HLWBO68 529323 298 119-199 2985 Gly-1 to Glu-6, H0328: 2 and H0553: 1. HLWBQ84 782938 299  3-263 2986 Lys-1 to Lys-41, AR089: 1, AR061: 0 Pro-75 to Ser-86. H0553: 2 HLWBQ86 703465 300 109-279 2987 Met-36 to Lys-41. H0553: 3 HLWBS14 925300 301 272-48  2988 Ala-37 to Glu-48. H0328: 1 and H0553: 1. HLWBS43 774175 302  2-268 2989 Glu-57 to Gly-66. H0553: 2 HLWBZ74 679215 303 184-2  2990 Asn-7 to Cys-15. H0030: 1, H0553: 1 and L0754: 1. HLWCA67 577929 304 114-848 2991 Pro-26 to Ser-39, H0031: 2, L0754: 2, Ile-66 to Ser-78, H0553: 1, L0743: 1, Lys-84 to Pro-105, L0748:1 and L0747: 1. Pro-171 to Pro-181, Arg-194 to Ala-199. HLWCM44 727699 305  57-314 2992 Ala-17 to Thr-24. H0553: 2 HLWCM70 926850 306 207-329 2993 H0553: 2 3p24-p22 116806, 168468, 182280, 190182, 190182, 227646, 261510, 600163, 601154 HLWCO66 750779 307  71-208 2994 Gln-16 to Met-21, H0553: 2 Val-25 to Lys-33, Ala-40 to Arg-46. HLWCQ53 869700 308 160-348 2995 Ser-11 to Gly-17. H0553: 2 and L0754: 1. HLWCQ62 742778 309 329-114 2996 Pro-10 to Lys-16. H0615: 3, H0553: 2, L0756: 2 and L0758: 2. HLWCQ76 768018 310  2-154 2997 H0553: 2, L0656: 1, L0659: 1, L0666: 1, L0664: 1 and L0748: 1. HLWDA01 913768 311  2-463 2998 Ile-31 to Ser-40, H0553: 2 Arg-115 to Gly-122. HLWDB18 790969 312  1-702 2999 Ser-21 to Glu-27, H0553: 2, H0038: 1, Gln-50 to Pro-59, L0764: 1, L0794: 1 and Gln-61 to Ser-66, L0438: 1. Thr-68 to Pro-74, Pro-77 to Gln-84. HLWDD02 953283 313  3-149 3000 H0553: 2 HLWDE60 868276 314 148-426 3001 Tyr-8 to Arg-14, H0553: 2 Asn-40 to His-46, Val-56 to Thr-62. HLWDL71 759843 315  1-51 3002 Pro-1 to Gly-12. H0553: 2 HLWEE76 973315 316  2-157 3003 Thr-18 to Met-25. H0553: 2 HLWFG82 929647 317  1-558 3004 Pro-4 to Pro-18, AR054: 2, AR051: 1, Gly-81 to Pro-87, AR089: 1, AR050: 1, Ala-110 to Ala-118, AR061: 0 Gln-127 to Gly-143, H0651: 59, L0751: 5, Arg-168 to Asp-176. L0438: 4, L0774: 3, L0439: 3, L0748: 2, L0779: 2, L0752: 2, L0755: 2, L0595: 2, H0295: 1, H0009: 1, T0010: 1, H0553: 1, H0617: 1, H0163: 1, H0102: 1, H0494: 1, L0770: 1, L0662: 1, L0375: 1, L0806: 1, L0776: 1, L0657: 1, L0659: 1, L0792: 1, L0666: 1, L0663: 1, L0664: 1, L0665: 1, L0352: 1, H0648: 1, L0740: 1, L0749: 1, L0757: 1, L0361: 1, L0603: 1 and S0042: 1. HLWFQ04 856488 318  1-402 3005 Phe-20 to Gly-26, H0553: 2 Ser-30 to Ser-37. HMVDU41 957804 319  2-289 3006 Ser-37 to Ala-46, H0651:29 and S0212:1. Cys-77 to Ser-85. HNBTP01 914428 320  3-512 3007 H0662: 2, H0670: 1, 22q12.1-q13.2 103050, L0756: 1 and L0759: 1. 103050, 124030, 124030, 138981, 182380, 188826, 190040, 190040, 190040 HNBTT79 965424 321  3-194 3008 Pro-12 to Ser-24, H0662: 2 Thr-42 to Ser-47, Pro-52 to Trp-59. HNBTX52 965428 322  52-339 3009 H0662: 2 HNBUM19 933672 323 209-472 3010 H0662: 2 HNBUR07 951814 324 203-412 3011 Lys-8 to Asn-14, H0662: 2 Lys-48 to Asp-53. HNGAO08 958685 325 300-115 3012 H0651: 177, L0794: 5, L0766: 5, H0657: 3, L0526: 2, L0666: 2, L0664: 2, L0744: 2, L0759: 2, S0212: 1, S0360: 1, H0587: 1, H0052: 1, H0050: 1, H0266: 1, H0428: 1, H0551: 1, H0412: 1, L0475: 1, H0646: 1, L0761: 1, L0662: 1, L0803: 1, L0805: 1, L0809: 1, L0665: 1, S0052: 1, S0374: 1, H0690: 1, H0659: 1, H0648: 1, H0521: 1, L0786: 1, L0779: 1, L0777: 1, L0780: 1, L0755: 1, H0543: 1 and S0424: 1. 959068 2654  81-284 5341 Ile-1 to Asp-7, Asn-39 to Pro-46. HNNNA06 917723 326 340-696 3013 Glu-15 to Asp-21, AR054: 7, AR050: 1, 2q35 118800, His-32 to His-45, AR051: 0 123660, Gly-55 to Lys-64, H0678: 47, L0748: 12, 125660, Gly-81 to Ser-88. L0754: 7, L0747: 6, 125660, L0755: 5, L0776: 4, 193500, L0740: 4, L0749: 4, 193500, L0759: 3, H0553: 2, 193500, L0665: 2, L0779: 2, 193500, S0282: 1, H0057: 1, 201460, H0674: 1, H0616: 1, 205100, H0646: 1, L0770: 1, 237300, L0769: 1, L0646: 1, 262000, L0765: 1, L0773: 1, 600266, L0777: 1, L0731: 1 and 601277 L0596: 1. HNNNA09 917724 327 320-520 3014 Glu-15 to Asp-21, H0678: 47, L0748: 12, 2q35 118800, His-32 to His-45. L0754: 7, L0747: 6, 123660, L0755: 5, L0776: 4, 125660, L0740: 4, L0749: 4, 125660, L0759: 3, H0553: 2, 193500, L0665: 2, L0779: 2, 193500, S0282: 1, H0057: 1, 193500, H0674: 1, H0616: 1, 193500, H0646: 1, L0770: 1, 201460, L0769: 1, L0646: 1, 205100, L0765: 1, L0773: 1, 237300, L0777: 1, L0731: 1 and 232000, L0596: 1. 600266, 601277 HNNNA77 917725 328  771-1019 3015 H0678: 2 2q35 118800, 123660, 125660, 125660, 193500, 193500, 193500, 193500, 201460, 205100, 237300, 262000, 600266, 601277 HNOAS06 933730 329 525-752 3016 Asp-28 to Ala-37, H0618: 3, L0758: 3, Arg-49 to Gly-58, L0794: 2, L0748: 2, Ala-63 to Asn-69. L0779: 2, L0755: 2, L0731: 2, L0770: 1, H0651: 1 and L0603: 1. HNOAX12 969363 330 231-524 3017 Pro-76 to Cys-88. H0651: 8, L0744: 2, L0598: 1 and L0756: 1. HNOBF57 927903 331 101-475 3018 Ala-2 to Lys-10, H0651: 154, L0731: 9, Glu-70 to Gln-76. L0777: 6, L0803: 4, L0775: 3, H0196: 2, H0163: 2, L0662: 2, L0805: 2, L0783: 2, L0438: 2, L0740: 2, L0759: 2, H0170: 1, S0444: 1, H0592: 1, H0632: 1, L0471: 1, H0399: 1, H0615: 1, H0040: 1, S0294: 1, H0647: 1, L0598: 1, L0763: 1, L0638: 1, L0637: 1, L0642: 1, L0374: 1, L0767: 1, L0768: 1, L0794: 1, L0804: 1, L0774: 1, L0375: 1, L0776: 1, L0606: 1, L0659: 1, L0809: 1, L0647: 1, L0789: 1, L0791: 1, L0666: 1, L0663: 1, L0664: 1, L0665: 1, H0659: 1, H0658: 1, H0672: 1, S0328: 1, H0539: 1, S0380: 1, L0439: 1, L0779: 1, L0594: 1, L0361: 1, S0026: 1, S0242: 1 and S0460: 1. HNOCQ04 964933 332  3-374 3019 H0651: 6 HNOCT39 952611 333  46-114 3020 Asn-18 to Lys-23. H0651: 3 HNCOU05 957833 334 536-745 3021 H0651: 2 HOCMU03 922418 335  8-220 3022 Asp-9 to Lys-20, H0660: 2 Ser-25 to Glu-30, Pro-57 to Asn-63. HOCPJ03 917484 336  3-185 3023 H0660: 2 HODAD73 973463 337  91-231 3024 Gly-42 to His-47. H0328: 3 HODAD95 974043 338 280-426 3025 H0328: 2 and H0615: 2. HODAG37 529410 339  48-236 3026 H0328: 2 HODAH32 859509 340  70-300 3027 H0328: 2 and L0534: 1. HODAJ01 921666 341  46-321 3028 H0328: 1 anD H0615: 1. HODAJ35 529405 342  76-216 3029 H0328: 2 HODAK38 529404 343 108-311 3030 Pro-10 to Cys-27, H0328: 2 Gln-41 to Arg-48. HODAK95 960179 344 147-398 3031 L0777: 4, H0328: 2, L0756: 2 and L0803: 1. HODAO16 529401 345  3-161 3032 Thr-3 to Lys-12. H0328: 2 HODAT56 529402 346  21-158 3033 Arg-15 to Thr-21, H0328: 2 Ser-38 to Glu-44. HODAV80 859519 347  85-300 3034 H0328: 2 HODAW60 692684 348 227-328 3035 H0328: 2 HODAW84 775425 349 142-297 3036 Thr-6 to Asp-14. H0546: 1, H0328: 1, L0779: 1 and L0361: 1. HODBC01 921662 350 166-303 3037 Gly-2 to Arg-10, H0328: 3 Ile-27 to Pro-33. HODBC07 954161 351 158-331 3038 Arg-27 to Trp-33. H0328: 2 HODBE01 921655 352  18-116 3039 Cys-14 to Pro-20. H0328: 2 HODBH16 927781 353  3-299 3040 Glu-23 to His-30, H0328: 2 Leu-41 to Asp-53. HODBO85 859559 354  1-168 3041 Lys-13 to Gln-21. H0328: 2 HODBT58 678444 355  2-166 3042 Ser-39 to Arg-45. H0328: 2 HODBU95 529329 356  59-280 3043 Glu-10 to Ala-17. H0328: 2 HODBV71 761447 357  71-343 3044 Ser-22 to Val-41. H0328: 1, H0059: 1 and L0596: 1. HODCA11 967732 358  1-180 3045 H0328:2 HODCA68 529400 359  2-184 3046 Leu-20 to Arg-25, H0328:2 Ser-47 to Gly-53. HODCD05 932218 360  2-286 3047 Glu-35 to Ile-40, H0328: 1 and H0038: 1. Pro-73 to Gln-79. HODCH64 529327 361  1-123 3048 Glu-1 to Thr-10. H0328: 2 HODCJ11 967320 362  20-175 3049 Gln-44 to Thr-51. H0328: 2 HODCJ42 932638 363  39-242 3050 Tyr-16 to Thr-22. H0328: 2 HODCL88 529334 364  1-222 3051 H0328: 2 and L0749:2. HODCM62 859556 365  87-275 3052 Gln-1 to Ser-7, H0328: 2 Arg-15 to Gly-21. HODCO09 573202 366  1-168 3053 Lys-27 to Leu-32, H0328: 2 Asp-49 to Asp-56. HODCO46 573200 367  2-196 3054 H0328: 2 HODCO82 573195 368 162-335 3055 H0328: 2 HODCP69 507249 369  3-185 3056 H0328: 2 HODCR43 529332 370 122-325 3057 Leu-1 to Lys-14. H0328: 2 HODCT07 954149 371 127-234 3058 Pro-14 to Ile-20, H0328: 2 Pro-23 to Pro-28. HODCU01 917270 372  -203 3059 Arg-1 to Pro-12. H0328: 2 HODCU02 920698 373 313-477 3060 Gly-8 to Thr-22. H0328: 1 and H0615: 1. HODCU62 524314 374 207-323 3061 Arg-5 to Cys-11. H0328: 2 HODCV09 973487 375 382-591 3062 Lys-7 to Glu-12. H0328: 3 HODCW17 960051 376 156-284 3063 Lys-37 to Ser-43. H0328: 2 HODCW37 575256 377  80-280 3064 Pro-49 to His-59. H0328: 2 HODCZ20 859580 378  82-273 3065 H0328: 2 HODDD20 933726 379  56-166 3066 Glu-21 to Glu-37. H0328: 1 and H0615: 1. HODDD41 529390 380  3-305 3067 Ala-8 to Ala-13, H0328: 2 Ile-17 to Gln-26, Phe-52 to Asn-64, Asp-72 to Lys-77. HODDE28 529169 381 137-277 3068 Gln-14 to Leu-22, H0328: 2 and H0615: 1. Lys-25 to Lys-35. HODDF51 937759 382  1-240 3069 H0328: 2 HODDG57 806204 383 127-468 3070 H0328: 1, H0615: 1 and L0748: 1. HODDH52 742217 384  18-329 3071 Val-26 to Lys-38, H0038: 2, H0328: 1 Lys-47 to Lys-53, and H0616: 1. Lys-60 to Leu-65, Ser-80 to Ile-90. HODDM21 523270 385  58-147 3072 Leu-16 to Arg-30. H028: 2 HODDM25 780472 386 387-566 3073 H0328: 1, H0615: 1 and L0748: 1. HODDM78 859516 387  83-286 3074 H0328: 2 HODDN40 859518 388 385-615 3075 Arg-10 to Arg-17, H0328: 1, H0615: 1 Ser-24 to Lys-30. and L0758: 1. HODDN59 975437 389 391-660 3076 H0615: 2 and H0328: 1. HODDN93 891236 390  60-371 3077 AR054: 28: AR050: 22, AR051: 13 H3028: 1, H0674: 1 and L0754: 1. HODDQ02 920962 391 101-283 3078 H0328: 2 HODDQ21 919295 392  3-359 3079 Tyr-11 to Gln-16, H0615: 2 and H0328: 1. Ala-24 to Ala-32, Pro-36 to Ser-41. HODDR13 529640 393  48-152 3080 H0328: 2 HODDS67 567197 394 171-338 3081 H0328: 2 HODDU70 529290 395  1-357 3082 Gly-1 to Pro-7. H0328: 2 HODDX35 531209 396 126-275 3083 Leu-9 to Gln-20. H0328: 2 HODEA90 782242 397 391-534 3084 H0615: 3 HODEB04 927022 398  1-282 3085 H0615: 3 HODEC76 952204 399 350-514 3086 H0615: 2 HODED11 966085 400  42-218 3087 Ile-12 to Thr-20, H0615: 3 Tyr-47 to Gly-57. HODED55 859368 401  24-296 3088 Thr-34 to Ser-40. H0615: 2 HODED87 915909 402  23-421 3089 Gln-3 to Arg-14, L0776: 2, L0740: 2, Pro-30 to Thr-36. H0484: 1, H0615: 1, L0809: 1, L0748: 1, L0750: 1, L0779: 1 and L0752: 1. HODEF10 963494 403 235-480 3090 H0615: 2 HODEF87 974342 404  27-266 3091 H0615: 3 HODEG86 784833 405 373-648 3092 H0615: 3 HODEH08 963895 406  2-142 3093 Pro-3 to Thr-10, H0615: 2 Ser-38 to Pro-47. HODEH22 974329 407 101-295 3094 H0615: 3 HODEI13 859318 408  66-227 3095 Ile-9 to Cys-14, H0615: 3 Pro-22 to Gly-27. HODEI48 841906 409 511-633 3096 Lys-1 to Ser-10. H0615: 3 HODEK50 859307 410 363-740 3097 Ser-25 to Pro-30, H0615: 3 Pro-84 to Glu-92. HODEL92 859313 411  45-188 3098 H0615: 2 HODEN75 772940 412 312-458 3099 H0615: 2 HODEO87 930735 413  1-159 3100 Val-9 to Val-15. H0615: 2 HODEP04 926984 414  69-269 3101 H0615: 2 HODEP12 965534 415 115-381 3102 H0615: 2 HODEP86 784846 416 215-364 3103 H0615: 2 HODEQ28 972808 417 206-331 3104 Thr-1 to Ser-13. H0615: 3 HODEQ79 859287 418 246-479 3105 H0615: 2 HEDER91 789661 419  1-351 3106 Phe-28 to Thr-33, AR061: 4, AR089: 2 Ile-44 to Thr-54, H0651: 709, L0766: 5, Arg-78 to Lys-88, L0754: 5, L0756: 3, Gln-99 to Lys-106. L0803: 2, L0779: 2, L0777: 2, L0759: 2, S0354: 1, H0643: 1, H0013: 1, H0194: 1, H0545: 1, H0373: 1, H0252: 1, H0615: 1, H0316: 1, H0040: 1, H0641: 1, H0647: 1, S0422: 1, L0598: 1, L0369: 1, L0520: 1, L0762: 1, L0649: 1, L0804: 1, L0527: 1, L0656: 1, H0144: 1, H0702: 1, H0547: 1, H0555: 1, H0436: 1, S0028: 1, L0746: 1, L0750: 1, L0780: 1, L0752: 1 and L0686: 1. HODES86 784815 420  3-278 3107 L0753: 3, H0615: 1 and H0683: 1. HODET03 922988 421  27-191 3108 Val-36 to Gly-42. H0615: 2 HODEV13 859302 422 433-639 3109 Asn-37 to Lys-42. H0615: 2 HODEX10 926260 423  22-159 3110 Met-1 to Arg-6, AR061: 6, AR089: 3 Ser-16 to Lys-29. H0615: 5 HODEX31 922473 424 129-524 3111 Pro-16 to Gly-45. H0615: 2 HODEY08 972984 425 425-667 3112 Glu-1 to Lys-7, H0615: 2 Thr-34 to Asn-43. HODEY13 859323 426 179-382 3113 H0615: 2 HODEY80 859296 427 432-677 3114 Gln-36 to Gly-41. H0615: 2 HODEZ02 918672 428  37-207 3115 Leu-27 to Ile-33, H0615: 2 and H0328: 1. Trp-43 to Gln-48. HODEZ11 952166 429 178-336 3116 H0615: 2 HODFA38 934266 430 170-397 3117 Ser-9 to Gly-15, H0615: 3 and L0367: 1. Pro-22 to Lys-27, Glu-43 to Glu-56. HODFB05 929733 431 451-639 3118 H0615: 2 HODFB57 972810 432  2-217 3119 Thr-1 to Ser-16. H0615: 2 HODFB88 792979 433 449-634 3120 H0615: 2 HODFD08 958371 434 133-270 3121 H0615: 2 HODFD10 963516 435 325-465 3122 H0615: 2 HODFD45 780531 436 169-399 3123 H0615: 2 HODFE69 859338 437  2-301 3124 Arg-46 to Ser-57, H0615: 2 Thr-67 to Cys-78. HODFG37 782219 438 263-433 3125 H0615: 2 HODFH02 915257 439  33-164 3126 Gln-15 to Ser-23, H0615: 3 Gly-30 to Lys-36. HODFH76 783783 440 143-391 3127 Lys-32 to Ser-37. H0615: 2 HODFJ01 859549 441 247-501 3128 H0328: 1 and H0615: 1. HODFK18 974313 442  44-343 3129 Ala-14 to Ser-38. H0615: 5 and L0665: 2. HODFK94 974318 443  42-182 3130 Ser-7 to Lys-15, H0615: 3 Val-17 to Pro-29. HODFL91 918456 444  1-159 3131 Pro-45 to Cys-51. H0615: 2 HODFN19 859334 445 198-425 3132 H0615: 2 HODFN42 921529 446  79-318 3133 H0328: 1 and H0615: 1. HODFO03 859329 447 124-309 3134 Asp-1 to Asp-7. H0615: 3 and H0328:2. HODFO37 859314 448  85-306 3135 Trp-44 to Thr-54. H0615: 2 HODFP40 921651 449 587-817 3136 Tyr-4 to Thr-11, H0328: 1, H0615: 1, Thr-15 to Asp-20, L0775: 1, H0648: 1 and Arg-29 to Leu-42. L0758: 1. HODFQ02 918637 450 427-615 3137 Tyr-1 to Cys-14, H0615: 3 Gln-20 to Ile-47. HODFQ06 934304 451 258-401 3138 Thr-1 to Asn-6. H0615: 2 HODFT52 915232 452 224-51  3139 H0615: 2 HODFU02 918536 453 204-398 3140 H0615: 2 HODFU06 934229 454 460-588 3141 Thr-1 to Ser-6. H0615: 3 HODFU47 806232 455 274-582 3142 Glu-1 to His-6, H0615: 2 and L0558: 1. Phe-13 to Pro-23, Arg-29 to Leu-34, Pro-54 to Asp-60, Pro-62 to Gly-67. HODFU54 965526 456  60-134 3143 H0615: 2 HODFW17 859322 457 370-603 3144 H0615: 2 OHDFX57 975259 458  1-183 3145 H0615: 3 HODFY16 958329 459 163-309 3146 AR061: 6, AR089: 3 H0615: 2 and L0766: 1. HODFY79 975253 460 393-259 3147 H0615: 3 HODFZ11 965104 461  45-209 3148 H0615: 2 and H0619: 1. HODGC04 926863 462  83-214 3149 Glu-9 to Gln-21. H0615: 2 HODGC61 973449 463  43-324 3150 Thr-50 to Gln-57. AR061: 8, AR089: 5 H0615: 3 HODGD05 931071 464  1-147 3151 Ala-8 to Gln-29, H0615: 2 Ser-36 to Gly-44. HODGH02 917969 465  28-285 3152 His-8 to Gly-18, H0615: 2 Leu-37 to Lys-42. HODGH04 926255 466  10-159 3153 His-8 to Gly-18, H0615: 2 Gly-26 to Arg-33. HODGH07 951933 467 178-330 3154 H0615: 2 HODGH11 965105 468 383-556 3155 H0615: 2 HODGH91 968794 469  91-333 3156 Arg-30 to Asn-35. H0328: 1 and H0615: 1. HODGI08 958235 470  1-267 3157 Arg-11 to Thr-29. H0615: 2 HODGJ67 974297 471  3-353 3158 Ser-2 to Thr-13, H0615: 3 Ile-16 to Ser-26, Pro-28 to Gln-36, Gln-41 to Pro-47. HODGL54 859303 472 402-698 3159 Pro-25 to Ser-31. H0615: 4 and H0328: 1. HODGM46 974051 473  2-304 3160 Phe-81 to Phe-87. H0615: 3 HODGO46 883087 474 292-525 3161 H0615: 2 HODGP37 974293 475  67-228 3162 H0615: 3 HODGP83 889967 476  3-236 3163 H0615: 2 HODGP95 908650 477  23-358 3164 Lys-38 to Arg-44, AR089: 8, AR061: 3 Thr-84 to Asp-99. H0615: 2 HODGQ08 958237 478 261-377 3165 H0615: 2 HODGQ22 974290 479 117-245 3166 H0615: 3 HODGQ32 974294 480 175-405 3167 Val-1 to Lys-7, H0615: 3 Gln-12 to Arg-18, Arg-22 to Gln-30, Gly-32 to Glu-40. HODGQ92 894368 481  2-274 3168 Asp-42 to Arg-47, AR061: 5, AR089: 2 Gln-84 to Gly-91. H0615: 2 HODGT62 974052 482 253-402 3169 H0615: 3 HODGW08 958277 483 183-371 3170 Ala-11 to Cys-16. H0615: 2 HODGX10 963427 484 206-310 3171 H0615: 3 HODGX29 913879 485 138-257 3172 H0615: 2 and H0658: 1. HODGZ06 933783 486 315-479 3173 H0615: 2 HODGZ10 961977 487  3-119 3174 H0615: 2 HODHC03 922987 488  3-341 3175 Pro-59 to Pro-65, H0615: 2 and L0777: 1. Glu-96 to Phe-113. HODHD16 974924 489 132-278 3176 Ala-1 to Glu-12. H0615: 3 and H0328: 1. HODHG71 926203 490 190-384 3177 Asp-1 to Lys-20, H0615: 2 Cys-34 to Ser-42. HODHH82 964935 491  78-293 3178 Thr-14 to Arg-22, H0328: 1 and H0615: 1. Ile-25 to Ser-35. HODHI07 952195 492 376-636 3179 Glu-33 to Lys-46. H0328: 1 and H0615: 1. HODHI26 973423 493 275-451 3180 H0615: 2 and H0328: 1. HODHK02 918613 494 108-302 3181 H0615: 3 HODHL19 973433 495  79-315 3182 H0615: 3 HODHL56 847724 496 185-415 3183 H0615: 2, H0188: 1 and L0758: 1. HODHO11 965529 497  36-137 3184 H0615: 2 HODHS34 965460 498 285-461 3185 H0615: 2 HODHY53 914554 499  47-214 3186 H0615: 2 HODJR03 922484 500 134-379 3187 H0615: 3 HODJY33 951404 501  31-384 3188 Lys-30 to Arg-36. H0615: 3 HODJZ90 965049 502  41-169 3189 Lys-8 to Ser-14. H0615: 2 HODKN07 933320 503  92-256 3190 His-20 to Val-35. H0615: 2 and L0060: 1. HOFAA15 659522 504  71-385 3191 Ile-13 to Arg-20. H0415: 1 and H0414: 1. HOFAB40 964113 505 527-99  3192 H0415: 2 and H0414: 1. HOFAB71 573337 506 100-249 3193 H0414: 2 HOFAD05 932211 507 118-306 3194 Pro-1 to Arg-8, H0415: 1 and H0414: 1. Pro-39 to Glu-56. HOFAE31 772992 508  2-220 3195 Glu-1 to Leu-8, H0414: 2 Arg-38 to Cys-49. HOFAE61 707359 509  3-293 3196 Val-18 to Arg-31, H0415: 1 and H0414: 1. Arg-57 to Cys-62. HOFAF84 868887 510 136-273 3197 Gly-30 to Gly-46. H0414: 2 HOFMA24 782275 511  63-347 3198 Ser-2 to Arg-15. H0415: 2 HOFMB78 572941 512  1-399 3199 Arg-10 to Lys-23. AR089: 26, AR061: 10 H0415: 8 and H0414: 2. HOFMB83 572839 513  3-158 3200 Thr-7 to Gly-18, H0415: 2 Pro-20 to Gly-26. HOFMD13 916959 514 232-405 3201 H0415: 2 HOFME41 867993 515  55-264 3202 H0415: 2 HOFMF03 924679 516  3-446 3203 Lys-36 to Ala-52, H0415: 2 Thr-54 to His-61, Pro-90 to Thr-96. HOFMF70 734917 517  1-387 3204 Pro-31 to Arg-36, H0415: 2 13q11-q12 121011, Glu-41 to Gln-52. 121011, 129500, 253700, 601885, 602221 HOFMG21 973358 518  66-497 3205 Pro-1 to Pro-6, AR089: 6, AR061: 3 1q42 106150, Asp-41 to Arg-67, H0415: 3 106150, Gly-100 to Val-106. 145260, 173870, 173870, 600759, 600996, 601744, 601975 HOFMH12 964722 519  2-478 3206 Arg-1 to Cys-16, H0415: 3 and H0414:1. Tyr-59 to Lys-68, Glu-76 to Arg-82. HOFMH38 920365 520  3-413 3207 Ser-85 to Gly-100, AR089: 5, AR061: 3 5 Pro-102 to Ser-113. H0415: 1 and H0414: 1. HOFMH95 973359 521  2-211 3208 Val-15 to Ala-22, H0415: 3 Val-26 to Gly-38, Gln-65 to Gly-70. HOFMI01 609722 522  2-121 3209 Cys-2 to Gly-7, H0415: 2 Ala-14 to Pro-20. HOFMI62 796358 523  3-452 3210 Asp-1 to Gly-22, H0415: 8 and H0414: 2. Pro-24 to Gly-34. HOFMI63 745133 524  1-225 3211 Ala-4 to Gly-11, H0415: 2 Pro-26 to Trp-31. HOFMJ44 719663 525  2-301 3212 Arg-1 to Asp-7, AR089: 30, AR061: 10 Ser-26 to Leu-39. H0415: 1 and H0414: 1. HOFMK22 675122 526  3-359 3213 Asp-22 to Val-42, H0415: 2 Phe-50 to Tyr-55, Leu-65 to Gln-70. HOFMM27 973349 527  1-132 3214 Ala-5 to Trp-19. H0415: 5 and H0414:1. HOFMM72 464015 528  49-366 3215 H0415: 2 HOFMN30 514556 529 422-234 3216 H0415: 2 HOFMP31 698097 530  2-202 3217 Gly-1 to Pro-6, H0415: 2 Pro-23 to Asp-28, Pro-36 to Ser-46, Lys-54 to Asn-63. HOFMP79 775242 531  2-445 3218 Gly-1 to His-12, AR089: 11, AR061: 3 Ser-40 to Pro-66, H0415: 2 Glu-79 to Lys-89, Glu-96 to Leu-105. HOFMQ04 823439 532  34-318 3219 Gly-11 to Leu-19, H0415: 1 and H0414: 1. Val-23 to Gly-32, His-34 to Ser-45. HOFMQ31 906933 533 183-449 3220 H0415: 4 HOFMQ65 789347 534  2-280 3221 Gly-1 to Ser-13, H0415: 2 Arg-26 to Glu-35, Gly-38 to Met-48. HOFMS68 464075 535 187-348 3222 H0415: 2 HOFMS74 514568 536 340-2  3223 Thr-4 to Gly-9, H0415: 1 and H0435: 1. Leu-32 to Glu-42, Pro-54 to Cys-68, Ile-97 to Gly-113. HOFMS89 575820 537  2-502 3224 Arg-34 to Thr-44, H0415: 2 Pro-65 to Gly-79, Leu-98 to Ser-105. HOFMT20 669738 538  2-157 3225 Asn-20 to Cys-29, H0415: 2 Val-33 to Ser-40. HOFMT43 811542 539  1-411 3226 Val-6 to Arg-12, H0415: 2 Pro-19 to Thr-36, Ser-49 to Thr-54, Glu-61 to Thr-67, Pro-77 to Ala-84, Ser-104 to Asn-114. HOFMT66 754251 540  2-169 3227 Arg-1 to Asn-8, H0415: 2 Lys-20 to Gly-38. HOFMT72 563575 541  3-248 3228 Gly-2 to Gly-9. H0415: 1 and H0414: 1. HOFMU33 702492 542  2-373 3229 Arg-1 to Gly-20, H0415: 2 Pro-45 to Ser-50. HOFMU63 744325 543  1-243 3230 His-8 to Trp-19. H0415: 2 HOFMU75 713809 544  2-121 3231 H0415: 2 HOFMV84 859109 545  3-230 3232 Lys-10 to Trp-15, H0415: 2 Pro-47 to Ser-55, Pro-67 to Phe-76. HOFNA04 615287 546 209-373 3233 Glu-19 to Gln-24, H0415: 2 Thr-30 to Lys-38. HOFNA92 792734 547  95-343 3234 Arg-1 to Gly-12. H0415: 2 HOFNC63 973354 548 203-3  3235 Tyr-1 to Pro-12. H0415: 2 HOFND14 658476 549  3-122 3236 H0415: 2 HOFND40 867984 550  54-341 3237 Pro-80 to Trp-88. H0415: 2 HOFND50 727285 551 446-90  3238 H0415: 2 HOFND52 727173 552 407-174 3239 AR054: 11, AR051: 3, AR050: 2 H0415 :2 888450 2655  2-325 5342 Ala-5 to Ala-13, Pro-15 to Lys-23, Ala-39 to Cys-44, Pro-47 to Cys-74, Ala-83 to Gly-90. HOFND90 716670 553  2-388 3240 Gly-1 to Asn-10, H0415: 2 Gln-30 to Asp-35, Gln-44 to Gly-54, Ser-61 to Val-89, Ser-92 to Ser-98. HOFND94 717067 554  67-225 3241 Thr-30 to Tyr-39. H0415: 2 HOFNG01 859106 555 140-280 3242 Gly-19 to Asn-24. H0415: 2 HOFNG06 935569 556  1-207 3243 Thr-18 to Trp-23. H0415: 2 HOFNH33 715101 557  3-152 3244 Asp-14 to Gly-20, H0415: 2 Arg-45 to Ala-50. HOFNI08 974435 558  1-426 3245 H0415: 4 HOFNI48 708727 559 140-376 3246 Pro-2 to Gly-13, H0415: 2 Gly-59 to Ser-64. HOFNI82 717355 560 117-362 3247 Gly-36 to Tyr-50. H0415: 3 HOFNL18 666498 561  1-405 3248 Ser-26 to Pro-33. AR089: 9, AR061: 3 H0415: 1 and H0414: 1. HOFNL25 916963 562  41-346 3249 Lys-54 to Ser-60, AR089: 8, AR061: 7 Tyr-86 to His-93. H0415: 3 HOFNL37 906250 563  2-394 3250 Gly-1 to Pro-6, H0415: 6, H0414: 2, 10p13 601362 Thr-24 to Ala-30, H0046: 1 and H0271: 1. Ser-33 to Pro-41, Ser-51 to Ser-61. HOFNL40 711205 564  1-225 3251 H0415: 2 HOFNL92 770088 565 244-414 3252 Gln-1 to Pro-8. H0415: 2 HOFNM85 869113 566  2-340 3253 H0415: 2 HOFNT59 615305 567 109-405 3254 Pro-7 to Ser-12, H0415: 2 Glu-37 to Ser-42, Leu-45 to Gly-53, Leu-68 to Val-75, Ser-81 to Thr-86. HOFNU72 705435 568  1-216 3255 H0415: 2 11p15.5 125852, 126452, 126452, 141900, 141900, 141900, 141900, 141900, 141900, 142000, 142000, 142200, 142250, 142270, 176730, 176730, 176730, 190020, 191290, 192500, 192500, 194071, 194071, 204500, 600856, 601680, 602631, 602631 HOFNW10 916588 569  28-237 3256 Lys-1 to Ser-14. H0415: 2 HOFNW79 973351 570  6-365 3257 H0415: 8 and H0414: 2. HOFNY02 920218 571 217-495 3258 H0415: 2 HOFNY50 715312 572  68-430 6259 Pro-15 to Pro-25, H0415: 2 Lys-68 to Glu-76, Lys-89 to Arg-107. HOFNZ15 660317 573  98-379 3260 Ser-18 to Ser-34. H0415: 2 HOFNZ16 859104 574  2-268 3261 Gly-1 to Pro-6. H0415: 2 HOFNZ21 677372 575 109-456 3262 Arg-1 to Gly-6. H0415: 2 9p13-p12 230400, 250250 HOFNZ58 683473 576  29-229 3263 H0415: 2 HOFNZ94 794308 577  99-218 3264 H0415: 1 and H0414: 1. HOFOA17 935553 578 142-369 3265 Gly-34 to Glu-39. H0415: 2 HOFOB88 751692 579  1-501 3266 Thr-2 to Val-11, H0415: 2 Leu-18 to Gly-25, Pro-30 to Ser-35, Ala-40 to Pro-47, Lys-62 to Glu-70, Lys-76 to Arg-82. HOFOB91 827631 580  1-234 3267 H0415: 2 HOFOE94 924473 581 173-382 3268 Thr-1 to Ser-11, H0415: 2 Ser-23 to His-29, Gly-53 to Gln-67. HOFOF57 666909 582  3-419 3269 H0415: 2 HOFOF84 739399 583  78-431 3270 Asn-1 to Gln-9, H0415: 2 Pro-17 to Ala-30. HOGAF39 947431 584  3-269 3271 Asp-1 to Leu-22, H0435: 1 and S0152: 1. Val-26 to Trp-38. HOGAU90 954011 585 247-402 3272 Cys-10 to Asp-19. H0615: 1 and H0435: 1. HOGAV36 926098 586 211-576 3273 Pro-8 to Lys-15, H0663: 2, L0761: 1, Arg-67 to Arg-74, L0771: 1 and H0435: 1. Arg-76 to Gly-85, Glu-91 to Gly-97, Thr-113 to Phe-120. HOGBF78 575929 587 264-443 3274 Lys-1 to Val-7. H0435: 2 and L0592: 1. HOGCQ05 950216 588 381-193 3275 Pro-12 to Ala-17, H0165: 1, H0435: 1 Val-29 to Gly-36. and L0747: 1. HOGCR32 575931 589  3-137 3276 Pro-3 to Lys-13, H0435: 2 Thr-39 to Ile-45. HOGCT45 717068 590  2-364 3277 Arg-1 to Glu-14, H0040: 1 and H0435: 1. Thr-39 to Gln-45, Pro-52 to Lys-62, Glu-89 to Thr-94. HOGCX95 890607 591  52-660 3278 H0038: 2, L0758: 2, H0253: 1, H0616: 1, H0435: 1 and L0777: 1. HOGEE76 968956 592 732-298 3279 H0435: 2 HOGEU49 961587 593  1-285 3280 Asp-25 to Ser-34, H0435: 1 and H0670: 1. Tyr-39 to Gln-44, Leu-84 to Lys-90. HOOJQ59 965013 594 418-621 3281 H0648: 2, L0367: 1, H0651: 1, L0748: 1 and L0754: 1. HOVAF17 576627 595 215-358 3282 H0428: 2 HOVAF71 757294 596  55-183 3283 H0428: 2 HOVAG49 927320 597  2-298 3284 H0428: 2 and L0588: 1. HOVAI41 670963 598  3-107 3285 H0428: 2 HOVAM50 723671 599  64-243 3286 Ser-22 to Arg-35, H0428: 2 Lys-39 to Gly-44. HPVAO76 770066 600  89-238 3287 Arg-15 to Gln-21. L0754: 2, H0428: 1 and H0616: 1. HPVBQ10 964671 601 515-763 3288 Lys-21 to Gly-26. L0777: 6, L0758: 5, L0747: 2, H0428: 1, L0770: 1, L0768: 1, L0533: 1, H0666: 1, L0750: 1 and L0755: 1. HOVBY34 706816 602  2-295 3289 Gly-1 to Ala-8, H0428: 2 Glu-67 to His-74. HOVBZ26 888442 603  3-215 3290 Gly-37 to Arg-46, AR051: 44, AR050: 43, Ser-57 to Trp-70. AR054: 30 H0428: 2 HOVCA52 727170 604 232-354 3291 H0428: 2 HOVCD39 705406 605  25-192 3292 Ser-8 to Leu-16. H0428: 2 HOVCI76 858845 606  60-284 3293 Arg-13 to Gly-18, H0428: 3 Gln-44 to Ser-50. HOVCI77 713792 607 119-241 3294 Lys-7 to Ser-16. H0428: 2 HOVCJ24 858844 608  68-319 3295 Leu-16 to His-22, H0428: 2 Cys-50 to Pro-55. HOVCM22 674177 609 219-482 3296 Ser-1 to Lys-14, H0674: 2, H0549: 1 Gln-48 to Asn-63, and H0428: 1. Glu-70 to Pro-88. HOVCO11 970814 610 157-423 3297 Val-11 to Leu-18. H0428: 2 and L0770: 1. 7p15 138079, 138079, 139191, 142959, 153880, 180104, 600994, 601649 HOVCO58 736065 611 283-420 3298 H0428: 2 HOVCQ47 496190 612  1-213 3299 L0758: 3, H0428: 2, L0794: 2, L0764: 1, L0803: 1 and L0593: 1. HOVDY04 926219 613  81-320 3300 Ser-25 to Gly-45. L0769: 4, L0758: 3, L0717: 2, H0428: 2, L0794: 2, L0731: 2, L0591: 2, L0776: 1, L0786: 1 and L0779: 1. HOVEE58 968699 614 131-3  3301 Thr-11 to Pro-21. H0428: 1 and H0032: 1. HOVEK70 909138 615  3-395 3302 Met-10 to Gly-18. AR089: 10, AR061: 4 H0038: 4, H0616: 3, L0747: 3, L0758: 3, L0663: 2, H0369: 1, H0428: 1, L0769: 1, L0542: 1, L0809: 1, L0666: 1, L0665: 1, L0743: 1, L0777: 1, L0731: 1 and S0456: 1. HOVEV36 959234 616 128-307 3303 H0428: 2 and H0546: 1. HOVJA10 961467 617  37-225 3304 H0688: 3 HPCAB21 573829 618  57-155 3305 S0146: 2 HPCAB31 698320 619  96-230 3306 H0658: 1, S0146: 1 and L0754: 1. HPCAE18 574952 620  2-355 3307 S0146: 2 12q24 113100, 124200, 147440, 158590, 160781, 163950, 163950, 251170, 276710, 600175, 601517, HPCAH18 573395 621 192-314 3308 S0146: 2 HPCAH88 953808 622 488-637 3309 S0146: 2, H0046: 1, S0148: 1, L0439: 1 and L0745: 1. HPCAI21 655535 623 134-259 3310 S0146: 2 HPCAI68 655536 624  58-168 3311 Lys-1 to Gln-6, S0146: 2 Met-15 to Thr-29. HPCAK16 662121 625 455-634 3312 H0615: 1, H0658: 1 and S0146: 1. HPCAK57 734931 626 265-420 3313 H0031: 1 and S0146: 1. HPCAL60 655723 627  41-142 3314 Gly-24 to Ser-34. S0146: 2 HPCAL86 924709 628  1-117 3315 Asn-12 to Ile-18. S0146: 2 HPCAM22 655607 629  64-234 3316 Asp-26 to Phe-39. S0146: 2 HPCAN59 655742 630  91-210 3317 S0146: 2 HPCAO04 655732 631 181-315 3318 S0146: 2 HPCPF05 927168 632  88-249 3319 H0659: 2 HPCPO07 951826 633  3-128 3320 Gly-29 to Tyr-34. H0659: 2 HPCQY57 927135 634  3-371 3321 Ser-34 to Gly-43, H0606: 1, L0803: 1 Lys-55 to Leu-71. and H0659: 1. HPDOT03 922481 635  1-384 3322 H0549: 1, L0773: 1, L0768: 1, L0794: 1, L0803: 1, H0658: 1 and L0747: 1. HPDOY06 929318 636  22-201 3323 H0658: 2 HPDPJ69 966158 637  92-436 3324 Arg-7 to Tyr-14. H0046: 17, H0658: 1 and H0672: 1. HPDPK12 969340 638 155-316 3325 H0658: 2 HPDPQ40 922464 639  2-223 3326 Ile-10 to Asn-36. L0520: 2, L0770: 2, H0658: 2, L0659: 1 and L0759: 1. HPDQO05 929274 640 588-875 3327 Ala-13 to His-22, L0748: 3, H0658: 2 Leu-80 to Arg-86. and H0660: 1. HPDRB01 914437 641 306-449 3328 H0658: 2, L0745: 2, H0644: 1 and L0529: 1. HPDRD28 957791 642 308-511 3329 H0658: 2 HPDRG92 967704 643  2-291 3330 Pro-51 to Phe-57, L0748: 3, H0658: 2 Ser-87 to Thr-94. and L0741: 1. HPDRO20 957678 644  2-163 3331 L0021: 1, H0658: 1 and H0672: 1. HPDVB07 951634 645 342-554 3332 Arg-5 to Cys-10, H0644: 2 and H0658: 1. Ser-22 to Ile-28. HPDVE05 928647 646 430-765 3333 Pro-22 to Asn-33, L0512: 5, L0513: 4, Arg-103 to Val-108. H0686: 3, L0509: 3, L0789: 3, L0761: 2, L0772: 2, L0764: 2, L0717: 1, L0800: 1, L0378: 1, L0776: 1, L0659: 1, H0658: 1 and L0747: 1. HPDVF03 922193 647 524-847 3334 H0046: 2, L0794: 1, L0766: 1, H0658: 1, L0748: 1, and L0758: 1. HPDVK12 968977 648  97-243 3335 L0374: 1. L0804: 1, L0805: 1, H0658: 1, H0648: 1, L0750: 1 and L0755: 1. HPDVM06 933443 649 439-591 3336 His-19 to Tyr-34, L0779: 2, H0032: 1 Glu-29 to Pro-47. and H0658: 1. HPDVY17 655902 650 226-444 3337 Gln-1 to Thr-6, H0658: 2 Ser-22 to Leu-27, Ser-32 to Phe-37. HPEAF19 867892 651  3-224 3338 H0165: 2 HPEBA06 960802 652 253-2  3339 Trp-1 to Pro-11, H0166: 1, H0059: 1 Ala-27 to Phe-34, and L0768: 1. Ser-46 to Thr-60. HPEBA51 723298 653  61-255 3340 Ile-18 to Asn-25. H0166: 2 and L0598: 1. HPEBD31 655760 654  3-200 3341 H0166: 2 and L604: 1. HPEBE44 716911 655 284-406 3342 Glu-31 to CyS-39. H0166: 1, H0673: 1, L0763: 1 and L0581: 1. HPEKG18 914115 656  1-96 3343 H0673: 2 HPEKJ42 922391 657  57-131 3344 H0673: 2 HPEKU27 921663 658 220-408 3345 H0328: 1 and H0673: 1. HEPKX12 969251 659  2-217 3346 Gly-1 to Asn-8, L0779: 2, H0428: 1, Pro-22 to Ser-31, H0673: 1, L0766: 1 and Thr-41 to Lys-48. L0658: 1. HPFAA06 960801 660 283-426 3347 H0168: 1 and H0169: 1. HPFCA36 524720 661  40-288 3348 Ser-12 to Ser-17, H0169: 2 6p21.1-p21.3 106300, Lys-24 to Ser-34. 108800, 120290, 120290, 120810, 120820, 142857, 142858, 150270, 167250, 170261, 177900, 179450, 179605, 179605, 179605, 179605, 179605, 180297, 201910, 217000, 222100, 233100, 235200, 248611, 256550, 256550, 263200, 600202, 600261, 600364, 601498, 601690, 601868, 602280, 602475 HPFCA71 655596 662 130-363 3349 Glu-28 to Gly-42. H0169: 2 HPFCF09 536666 663 152-355 3350 H0169: 2 HPFCF24 655744 664 186-398 3351 H0169: 2 HPFCF40 968600 665 242-189 3352 Ser-2 to Pro-10. H0169: 2 HPFCF83 781490 666  38-193 3353 Ala-38 to Ser-48. H0169: 2 HPFCH15 655768 667 154-357 3354 Met-4 to Leu-9, H0169: 2 Gly-39 to Gln-46. HPFCH89 655538 668  65-139 3355 Ser-15 to Leu-23. H0169: 2 HPFCM41 655736 669 135-287 3356 H0169: 2 HPFCM87 925495 670  2-244 3357 Leu-18 to Arg-25, H0169: 2 Gly-35 to Lys-40. HPFCN08 960365 671  20-166 3358 Ser-18 to Thr-25. H0169:2 and L0519: 1. 22q13.1 103050, 103050, 124030, 124030, 138981, 182380, 188826, 190040, 190040, 190040 HPFCO02 867871 672  1-210 3359 Glu-11 to Thr-19. H0169: 2, L0749: 2 and L0748: 1. HPFCO67 867880 673 136-306 3360 H0169: 2 HPFCQ88 655749 674 273-401 3361 H0169: 2 HPFCR21 655621 675 190-411 3362 H0169: 2 HPFCR82 655533 676 140-286 3363 Lys-9 to Thr-14, H0169: 2 Glu-21 to Pro-26. HPFCT09 655563 677  13-120 3364 Met-1 to Cys-9. H0169: 2 HPFCT53 974257 678 271-522 3365 Ile-3 to Ala-14, H0169: 3 Arg-63 to Pro-68. HPFCT62 655432 679  82-198 3366 Glu-9 to Arg-15, H0169: 2 Pro-24 to Tyr-39. HPFCV19 655706 680  79-195 3367 Leu-5 to Ser-11, H0169: 2 and L0776: 1. Pro-13 to His-19, Lys-34 to Tyr-39. HPFCV71 525554 681  1-240 3368 Gly-22 to Cys-32. H0328: 1, H0615: 1, H0169: 1, L0807: 1 and L0754: 1. HPFCX18 655588 682 153-263 3369 Ser-16 to Asp-26. H0169: 2 HPFDD06 960700 683  2-163 3370 Lys-23 to Val-34. H0169: 2 HPFDE38 655704 684  67-330 3371 Leu-4 to Lys-18, H0169: 2 and L0809: 1. Gly-36 to Glu-45, Lys-60 to Cys-65. HPFDE61 974249 685 392-538 3372 Asp-1 to Arg-7, H0169: 4 Thr-17 to Asn-22, Leu-25 to Pro-30. HPFDF79 973732 686 156-320 3373 Ser-3 to Tyr-9. H0169: 3 HPFDG58 655610 687 123-318 3374 Cys-32 to Phe-38. H0169: 2 HPFDI23 655549 688 197-367 3375 Leu-5 to Gly-10. H0169: 2 HPFDL90 654333 689  2-202 3376 H0169: 2 HPFDS59 655543 690  8-160 3377 H0169: 2 HPFDT17 581133 691 166-342 3378 Pro-18 to Asn-25. H0169: 2 HPFDT54 655530 692  36-212 3379 H0169: 2 and L0763: 1. HPFDT61 974569 693  63-173 3380 H0169: 3 HPFDU30 522113 694  2-232 3381 His-46 to Pro-51. H0169: 2 HPFDU38 867879 695  36-167 3382 H0169: 2 HPFDU59 739617 696 214-369 3383 H0169: 2 HPFDV71 867870 697 124-354 3384 Pro-14 to Gly-25. AR050: 117, AR054: 88, AR051: 81 H0169: 2 HPFDX13 655571 698  1-294 3385 Val-1 to Lys-11, H0169: 2, L0747: 2, Pro-24 to Asp-33, H0688: 1, L0770: 1, Lys-44 to Glu-58. L0803: 1, L0748: 1 and L0756: 1. HPFDZ20 655764 699  25-213 3386 H0169: 2 HPFEA08 960372 700  2-187 3387 Ile-1 to Gly-44. H0169: 3 HPFEA32 925499 701 142-309 3388 H0169: 2 HPFMA06 953536 702  63-212 3389 Ala-7 to Arg-12. H0674: 2 HPFML02 917775 703  39-113 3390 Lys-9 to Leu-15. H0674: 2 HPIAE79 655748 704  17-394 3391 Asn-1 to Lys-7, S0150: 2 Pro-14 to Cys-23. HPIAO83 655595 705  2-334 3392 Ser-1 to Arg-7, S0150: 2 Pro-57 to Trp-67, Pro-70 to Ala-75, Ser-87 to Gly-95. HPIAQ49 919469 706 106-243 3393 Pro-39 to Glu-46. S0150: 2 HPIAQ76 655573 707 61-2  3394 Lys-1 to Lys-17. S0150: 2 HPIAS40 928614 708  2-463 3395 Gly-1 to Val-6, H0484: 1 and S0150: 1. Asp-25 to Gln-42. HPIAV80 615007 709  64-174 3396 Ser-8 to His-16. S0150: 2 HPIAX11 925424 710 282-608 3397 AR061: 9, AR089: 7 H0616: 1, S0150: 1 and L0581: 1. HPIAZ37 655753 711  2-289 3398 S0150: 2 HPIBQ37 884289 712  2-424 3399 Ile-47 to Val-53, AR089: 4, AR061: 2 Phe-71 to Thr-76, S0150: 2 Ser-105 to Thr-113, Glu-121 to Ser-129. HPIBR51 725539 713  1-468 3400 Ala-15 to Ser-21, H0546: 1 and S0150: 1. Gln-30 to Asp-36. HPIBT49 655719 714 176-283 3401 Tyr-30 to Cys-36. S0150: 2 HPIBY65 655757 715 133-294 3402 S0150: 2 HPICC89 786117 716 211-414 3403 L0439: 2, H0616: 1, and S0150: 1. HPJAB19 655540 717  1-153 3404 S0152: 2 HPJAB84 655531 718  3-269 3405 His-1 to Asp-6, S0152: 2 Ala-16 to Ala-25. HPJAC36 655601 719 154-330 3406 Cys-5 to Gly-12, S0152: 2 and L0780: 1. Ser-47 to Arg-52. HPJAC92 867831 720  3-251 3407 His-1 to Leu-19. S0152: 2 HPJAD09 655712 721 180-332 3408 S0152: 2 HPJAD66 655694 722 141-290 3409 Val-2 to Ser-14, S0152: 2 Gly-27 to Ala-37. HPJAD82 655765 723  53-187 3410 Arg-5 to Lys-13, S0152: 2 Ser-20 to Thr-25. HPJAV07 952852 724 180-335 3411 Leu-43 to Cys-51. S0152: 2 HPJAW56 823393 725 346-594 3412 L0748: 3, S0152: 2, H0615: 1, H0617: 1 and L0758: 1. HPJBI17 655761 726 162-326 3413 Ser-29 to Arg-35. S0152: 2 HPJBI89 655708 727  1-81 3414 Ser-19 to Gln-25. S0152: 2 HPJBK52 655751 728  99-263 3415 S0152: 2 HPJBU08 958979 729  29-193 3416 Gln-13 to Thr-18, S0152: 2 His-40 to Met-45. HPJBV17 655729 730  10-123 3417 S0152: 2 HPJCC04 926787 731  32-370 3418 Asn-42 to Gly-51. S0152: 2 HPJCP10 964259 732 113-244 3419 S0152: 2 HPJCP11 966676 733  95-337 3420 Pro-36 to Gly-62. H0056: 1 and S0152: 1. HPJCS84 590404 734  2-286 3421 S0152: 2 HPJCV50 968095 735 260-460 3422 Ala-14 to Lys-21, H0253: 1 and S0152: 1. Asp-37 to Gly-48, Gly-60 to Leu-65. HPJCX15 655730 736 245-334 3423 S0152: 2 HPJCX26 655600 737 239-349 3424 S0152: 2 HPJCY70 655569 738 111-203 3425 Pro-3 to Cys-11. S0152: 2 HPJCZ03 922850 739  79-183 3426 Val-2 to Thr-8. S0152: 2 HPJCZ06 934170 740 102-242 3427 Ser-1 to Gly-16. S0152: 2 HPJDA08 958182 741  438-1031 3428 Leu-8 to Lys-19, S0152: 2 and L0070: 1. Asp-25 to Arg-33, Ser-40 to Ser-63, Ala-70 to Val-77, Glu-91 to Asp-97, His-108 to Asn-116, Lys-130 to Glu-136, Asp-139 to Val-144. HPJDJ58 906904 742 386-556 3429 S0152: 2 HPJDP05 931027 743 299-454 3430 H0615: 2 and S0152: 1. HPJDX94 838748 744  79-183 3431 S0152: 2 HPJEE38 954970 745 292-483 3432 Ser-23 to Arg-28. L0770: 2, L0779: 2, H0553: 1, L0766: 1, L0666: 1, S0152: 1 and L0777: 1. HPJEI55 926815 746  14-130 3433 Gly-1 to Pro-7. S0152: 2 HPJEJ39 930988 747 284-538 3434 Gly-1 to Ala-11. S0152: 2 HPJEQ04 927618 748 149-329 3435 H0435: 1 and S0152: 1. 11 HPJEQ22 867725 749 239-448 3436 Thr-29 to Gly-38. S0152: 2 HPJET90 836503 750  39-377 3437 His-8 to Gly-18, AR061: 0, AR089: 0 Leu-40 to Ile-45, S0152: 2 Asn-100 to Asp-105. HPJEV06 934096 751  70-213 3438 Leu-17 to Glu-23, S0152: 2 Arg-27 to Glu-35. HPLAN47 717680 752  49-189 3439 Gly-1 to Arg-9. L0754: 39, L0748: 7, H0553: 4, H0030: 1, L0142: 1 and S0454: 1. HPLAR41 557554 753 236-3  3440 H0030: 2 HPLBB50 503751 754 287-72  3441 H0030: 2 HPLBL31 503732 755  16-183 3442 Gly-1 to Ala-7, H0030: 2 Pro-42 to Asn-47. HPLBL57 503730 756  57-245 3443 Phe-29 to Lys-35. H0030: 2 HPLBO61 558187 757  2-241 3444 Glu-1 to Thr-9. H0030: 1, H0038: 1 and L0758: 1. HPMAG19 705471 758  40-153 3445 H0031: 2 HPMAH75 766443 759  2-214 3446 H0031: 2 HPMBK34 954057 760  1-147 3447 H0031: 2 HPMBK49 577661 761 125-301 3448 Gln-20 to Ser-31. H0031: 2 and L0777: 2. Phe-41 to Gly-47. HPMBM48 575626 762  3-503 3449 Tyr-19 to Gly-46, H0031: 3 Ser-48 to His-59, Gly-65 to Gly-77, Thr-91 to Tyr-96. HPMBN02 920865 763  1-120 3450 H0031: 2 HPMBO10 968365 764  39-278 3451 H0031: 4 HPMBO61 867677 765  1-249 3452 Gly-1 to Gly-8. H0031: 3 HPMBR17 785732 766 192-404 3453 Thr-1 to Gln-7, H0031: 2 Pro-24 to Gly-32. HPMBU81 557870 767  28-165 3454 Ser-32 to Thr-41. H0031: 2 HPMBX35 531058 768  3-125 3455 H0031: 2 HPMBX79 577637 769 118-276 3456 H0031: 2 HPMBY76 531338 770  2-163 3457 Tyr-25 to Gly-32. H0031: 2 HPMBY83 527006 771  90-341 3458 Ser-50 to Gly-55. H0031: 4 and L0803: 1. 12 HPMBZ05 932527 772  62-196 3459 H0031: 2 HPMCB65 531289 773 111-302 3460 Gly-12 to Ile-18. H0031: 2 and L0605: 1. HPMCC73 531066 774 171-314 3461 Pro-28 to Pro-42. H0031: 2 HPMCD77 529960 775  3-278 3462 Asp-1 to Cys-6. H0253: 1 and H0031: 1. HPMCI02 381961 776 326-66  3463 Leu-19 to Thr-25, H0031: 2, L0809: 1, Arg-66 to Phe-87. L0438: 1 and L0439: 1. 881473 2656  3-341 5343 HPMCI65 577598 777  27-161 3464 H0031: 2 HPMCJ14 524768 778  93-317 3465 Glu-30 to Asp-40. H0031: 3 HPMCJ19 531279 779  1-243 3466 H0031: 2 HPMCJ48 577601 780  44-304 3467 H0031: 2 HPMCK65 742095 781  54-314 3468 Leu-6 to Leu-16, H0031: 2 and L0600: 1. Thr-24 to Trp-29. HPMCS19 954056 782  3-182 3469 Gln-1 to Gln-9, H0031: 3 Arg-15 to Gly-22. HPMCS65 961250 783  16-108 3470 Tyr-1 to Arg-8. H0031: 10 HPMCV93 657532 784  31-186 3471 Arg-5 to Trp-15. H0031: 3 and L0594: 1. HPMCW25 867673 785  1-285 3472 Gly-1 to Ser-8, H0031: 2 and L0758:1. Leu-36 to Gly-42, Leu-48 to Asn-55, Lys-83 to Met-91. HPMCW53 727392 786  2-202 3473 Pro-19 to Lys-26, H0031: 2 Pro-36 to Gly-55. HPMCX11 967655 787 115-312 3474 Gln-6 to Thr-19. H0031: 2 and L0662: 1. HPMCY30 867687 788 119-271 3475 Asp-7 to Leu-12, H0031: 2 Ala-16 to His-21. HPMCY31 725180 789 189-338 3476 H0031: 2 HPMCY35 571411 790 272-397 3477 H0031: 3, L0667: 1 and L0748: 1. HPMDJ09 582594 791 108-215 3478 H0031: 4 HPMDL78 577590 792  49-330 3479 Glu-1 to Pro-6, H0031: 2 Thr-45 to Val-50. HPMDO39 531275 793  55-204 3480 H0031: 2 HPMDR07 867682 794  33-227 3481 H0031: 2 HPMDT91 745346 795  3-299 3482 Gly-38 to Ser-45, H0031: 2 Gly-72 to Gly-78. HPMDU19 577626 796 163-276 3483 L0748: 14, H0553: 4, L0754: 4, H0644: 3, H0031: 2, L0005: 1, L0774: 1, S0454: 1, L0749: 1 and L0780: 1. HPMDY82 531274 797  7-51 3484 Lys-8 to Lys-15. H0031: 2 HPMDZ62 531276 798 116-286 3485 Phe-5 to Gly-10. H0031: 2 and H0644: 1. HPMEB66 531349 799  3-149 3486 Lys-20 to Thr-31. H0031: 2 HPMEC16 867658 800 136-249 3487 H0031: 2 HPMEC36 668897 801  92-214 3488 H0031: 2 HPMEC69 702501 802  1-114 3489 Ile-29 to Ile-36. H0031: 2 and L0740: 1. HPMED52 531347 803  2-451 3490 Lys-23 to Ser-33. AR061: 6, AR089: 3 H0031: 3 HPMEE48 531321 804 240-437 3491 H0031: 4 HPMEE66 577619 805 182-319 3492 H0031: 2 HPMEG50 925080 806  3-122 3493 Pro-20 to Pro-26. H0031: 2 HPMEI39 784781 807 117-443 3494 Arg-1 to Ser-8, H0031: 3, L0731: 3, 22q12-q13 102480, Pro-23 to Gly-30, H0046: 2, L0617: 1, 123620, Glu-62 to Arg-68. L0747: 1 and L0779: 1. 133450, 133450, 138981, 188826, 190040, 190040, 190040, 600850, 601669, 602229 HPMFB02 920308 808  3-404 3495 Pro-15 to Leu-27, H0031: 2 4q31.1-q31.2 189800, Phe-44 to Asp-49, 600983 Ala-83 to Lys-99. HPMFB28 575934 809  3-281 3496 Asp-37 to Thr-43, H0031: 3 Ala-46 to Ala-53, His-64 to Trp-76. HPMFB37 575620 810 277-465 3497 H0031: 8 and L0581: 2. HPMFB75 526594 811  46-234 3498 H0031: 2 HPMFB84 577593 812 148-291 3499 Leu-2 to Glu-8, H0031: 2 Pro-39 to Ser-44. HPMFE35 577633 813  3-158 3500 Gln-14 to Thr-22. H0031: 2 HPMFE60 577636 814  2-214 3501 Ser-8 to Ser-14, H0031: 2 Ser-27 to Pro-48. HPMFE73 575941 815  1-183 3502 Pro-38 to Gly-45. H0031: 2 HPMFH21 575943 816 248-460 3503 H0031: 2 HPMFJ50 575932 817 170-487 3504 Gln-7 to Ser-12. H0031 ;2, L0438: 2 and L0439: 2. HPMFJ55 577588 818  53-259 3505 H0031:5 HPMFL08 959569 819 191-346 3506 Met-43 to Trp-52. AR089: 1, AR061: 1 H0031: 2 HPMFL80 874359 820  2-205 3507 Ala-1 to Lys-6, H0031: 2, H0644: 1 Pro-12 to Trp-19, and L0527: 1. Met-63 to Lys-68. HPMFM29 582595 821 482-631 3508 H0428: 1, H0031: 1, L0766: 1, L0659: 1, H0690: 1, L0439: 1, L0754: 1 and L0756: 1. HPMFN12 968821 822 262-444 3509 Arg-15 to Val-21. H0031: 3 HPMFP05 867662 823 107-427 3510 Leu-9 to Ile-17. H0031: 2 HPMFP30 577629 824 121-348 3511 H0031: 3 HPMFP38 575914 825 118-261 3512 H0031: 3 HPMFQ84 867651 826 483-692 3513 H0031: 4 and L0754: 1. HPMFS41 711640 827  64-342 3514 Ala-1 to Asn-9, H0031: 3 Glu-17 to Glu-22, Trp-36 to Gln-44. HPMFT04 916662 828  28-180 3515 H0031: 4 HPMFU89 575894 829 169-300 3516 Tyr-24 to His-32. H0031: 2 HPMFV28 652097 830 172-312 3517 Lys-1 to Gly-7. H0031: 2 HPMFV82 575911 831  57-167 3518 Phe-15 to Asn-20. H0031: 2 HPMFV88 956263 832 204-365 3519 Gln-10 to Gln-20. H0031: 2 HPMFW25 960065 833  16-246 3520 Arg-18 to Val-24, H0031: 2 Glu-43 to Gly-54. HPMFW78 932529 834  3-152 3521 Asp-19 to Ser-30. H0031: 5 and L0142: 1. HPMFX13 575908 835 284-412 3522 Leu-34 to Cys-41. L0774: 4, H0031: 2, L0439: 2, L0435: 1, L0803: 1 and H0670: 1. HPMFX65 867657 836 158-355 3523 H0031: 2 HPMFX70 577642 837  3-218 3524 His-1 to His-7, H0031: 2 Ser-16 to Glu-22, Phe-65 to Ser-71. HPMFX92 577603 838  3-206 3525 Arg-28 to Leu-37. H0031: 2 HPMGA83 968359 839  88-243 3526 His-39 to Thr-44. H0031: 4 HPMGB22 506379 840 180-320 3527 H0031: 2 HPMGC07 920313 841  55-381 3528 Gln-6 to Trp-17. H0031: 9 and L0758: 1. HPMGC23 703835 842  1-306 3529 Arg-18 to Ser-29, H0031: 2 Gly-62 to Tyr-78. HPMGE31 867648 843  30-353 3530 H0031: 2 HPMGE95 873392 844 176-340 3531 H0031: 3 HPMGF06 954823 845  1-564 3532 Gly-1 to Ser-16, H0031: 3, H0651: 1, Ser-37 to Lys-42, L0731: 1 and L0758 1. Arg-44 to Val-50. HPMGF32 577615 846 226-92  3533 Tyr-1 to Ile-7, H0031: 2 Cys-20 to Asp-33, Leu-40 to Ser-45. HPMGH16 577641 847 267-398 3534 H0031: 2 HPMGI03 924521 848  62-283 3535 H0031: 2 20 HPMGI84 920326 849  79-219 3536 H0031: 3 HPMGJ93 864040 850 147-359 3537 Trp-40 to His-45. H0031: 2 HPMGK37 575924 851 223-369 3538 H0031: 2 HPMGK59 671936 852 159-488 3539 His-18 to Cys-23, H0031: 3, L0757: 3, Glu-33 to Phe-40, L0803: 2 and L0766: 1. Thr-42 to Trp-47, Cys-53 to Glu-63. HPMGK62 730751 853 347-529 3540 H0031: 3 and L0754: 1. HPMGM33 854081 854  2-223 3541 Ala-1 to Asn-16, L0805: 5, H0031: 2, Lys-45 to Thr-54. L0749: 2, L0766: 1, L0776: 1 and L0779: 1. HPMGM54 577599 855 189-356 3542 H0031: 2 HPMGR80 506235 856  24-224 3543 H0031: 2 7p15-p12 138079, 138079, 139191, 142959, 153880, 180104, 600994, 601649 HPMGS09 575951 857  46-111 3544 H0031: 2 HPMGS24 796440 858 230-367 3545 H0031: 2 HPMGT67 970815 859  1-123 3546 Ser-26 to Trp-32. H0031: 2 HPMGV12 968364 860  35-301 3547 His-1 to Glu-6. H0031: 2 HPMGV15 582596 861  88-210 3548 H0031: 4 HPMGV59 577635 862  38-277 3549 Asp-23 to Pro-34. H0031: 2 HPMGW48 920309 863  3-257 3550 His-1 to Gln-15, H0031: 2 Arg-37 to Asp-48, Ser-63 to Pro-77, Gly-79 to Lys-85. HPMGX23 575903 864  3-314 3551 Ser-2 to Pro-27, H0031: 2 19q12 Leu-38 to Asn-52. HPMHA80 970813 865 142-294 3552 H0031: 2 HPMHB74 577595 866 289-552 3553 Lys-31 to Thr-37. H0031: 2, L0769: 1 and L0439: 1. HPMHB83 531382 867  1-147 3554 Gly-1 to Ser-8, H0031: 3 Ile-41 to Ile-49. HPMHC74 577631 868  46-198 3555 H0031: 2 HPMHD66 928433 869  1-441 3556 Arg-13 to Ala-23, H0031: 2 Met-27 to Gly-36, Ser-109 to Leu-116. HPMHD71 760426 870 159-1  3557 Arg-1 to Thr-20. H0031: 3 HPMJC01 914759 871  1-267 3558 H0031: 1 and H0644: 1. HPMJC05 930844 872  2-370 3559 Leu-39 to Ser-46, H0644: 2 Gly-87 to Pro-94. HPMJD88 930806 873 136-330 3560 Gln-42 to Asp-50. H0644: 3 HPMJE84 867587 874 207-425 3561 Ile-1 to Gln-10, H0644: 2 Ser-20 to Gln-27. HPMJF76 956542 875  1-171 3562 H0644: 2 HPMJI81 930873 876 166-276 3563 Glu-15 to Arg-20. H0644: 2 and H0615: 1. HPMJN59 946876 877  84-470 3564 AR089: 21, AR061: 15 H0644: 2 HPMJQ46 922649 878  1-222 3565 Ala-1 to Phe-6, H0644: 2 Thr-32 to Gly-38, Pro-54 to Gln-73. HPMJR02 917419 879 160-429 3566 Arg-37 to Asn-50, H0644: 2 His-81 to Gln-89. HPMJV08 958001 880 204-353 3567 Tyr-15 to Tyr-21. H0644: 3 HPMJY55 922657 881  3-203 3568 H0644: 3 HPMKB19 969478 882 287-454 3569 Ser-8 to Phe-26. H0644: 2, L0794: 1 and L0748: 1. HPMKI53 957997 883  3-125 3570 H0644: 2 HPMKM81 894416 884  64-567 3571 Arg-15 to Gln-21, AR061: 2, AR089: 1 7q22 126650, Gln-47 to Ile-53, L0666: 3, L0777: 2, 126650, Lys-58 to Asp-72. L0608: 2, H0046: 1, 154276, H0031: 1, H0644: 1, 173360, L0803: 1, L0783: 1, 173360, H0672: 1, L0740: 1, 602136, L0750: 1 and L0755: 1. 602136, 602136, 602447 HPMKN43 867573 885 222-545 3572 Arg-2 to Tyr-7. H0644: 2 and L0589: 1. HPMLE04 867533 886 343-543 3573 H0644: 3 and L0471: 1. HPMLK02 918123 887 173-421 3574 Leu-36 to Gln-52. H0644: 2 and L0527: 1. HPMLK76 922621 888 155-370 3575 Arg-43 to Ser-48. H0644: 2 HPMLL74 953069 889  1-285 3576 Gly-4 to Ser-11. H0544: 1, H0644: 1 and L0754: 1. HPMLW10 963037 890  53-211 3577 H0644: 2 HPMSF86 509490 891  44-226 3578 Ser-8 to His-17. H0111: 2 HPRAE13 971652 892  3-329 3579 Gly-8 to Glu-21, H0032: 2 and L0759: 1. Val-23 to Ser-37. HPRAN84 585489 893  87-299 3580 Cys-19 to Ser-29, H0032: 2 Ser-31 to Gly-37, His-48 to Gln-53. HPRAU45 536630 894 191-27  3581 Ser-12 to Gln-18, H0032: 2 Arg-23 to Gly-30. HPRAZ10 968692 895  1-183 3582 Gln-13 to Ile-22, L0758: 2, H0688: 1 Val-34 to Ser-39. and H0032: 1. HPRBA65 655537 896  98-241 3583 Arg-23 to Glu-35. H0032: 2 HPRBE36 655587 897  91-330 3584 Ile-6 to His-11, H0032: 2 Gly-24 to Val-29. HPRBL91 655693 898 192-299 3585 H0032: 2 HPRCB11 960316 899 178-336 3586 Ser-13 to Asn-20. H0032: 2 HPRCB21 655725 900  2-121 3587 Ser-19 to Ser-25. H0032: 2 HPRCC08 939490 901  3-296 3588 Leu-39 to Ile-47. H0032: 2 HPRCC61 964909 902  3-176 3589 H0032: 2 HPRCN41 655554 903  23-169 3590 H0032: 2 HPRCU13 968521 904 156-269 3591 H0032: 2 HPRSB16 666295 905  3-188 3592 H0211: 2 HPRTL26 849081 906 258-419 3593 Gln-1 to Gly-7, H0212: 2 and H0032: 1. Thr-22 to Gly-31. HPRTP73 708761 907 127-273 3594 H0032: 1 and H0212: 1. HPVAB11 967944 908 295-495 3595 Arg-8 to Phe-20, L0777: 3, L0662: 1, 20 Gly-36 to Lys-42. L0803: 1, L0787: 1, H0672: 1, S0013: 1 and L0747: 1. HPVAF49 655578 909 108-287 3596 Arg-4 to Ser-20, S0013: 2 Lys-50 to Glu-60. HPVAF69 753744 910  2-145 3597 Ile-22 to Asn-28. L0662: 1, L0774: 1, L0659: 1, H0672: 1, S0013: 1 and L0754: 1. HPVAH36 525537 911 204-362 3598 Ser-3 to Gly-11, T0069: 1 and S0013: 1. Thr-41 to Gly-52. HPWAF85 655691 912 116-550 3599 Arg-39 to Asp-55, S0044: 2 and H0618: 1. 19q Ala-93 to Ser-99, Pro-102 to Ser-111. HPWAH48 655527 913  19-156 3600 Asn-6 to Trp-17. S0044: 2 HPWAS77 908450 914 655-266 3601 His-18 to Pro-24. AR061: 7, AR089: 3 S0044: 2, L0747: 2, L0777: 2 and L0480: 1. HPWBA33 655733 915  66-227 3602 Ala-7 to Thr-13, S0044: 2 Arg-43 to Arg-49. HPWBO84 867289 916  14-289 3603 Arg-44 to His-50, S0044: 2 Gln-62 to Arg-69, Gln-80 to Trp-87. HPWCA53 657484 917 197-367 3604 Phe-24 ro Thr-29. S0044: 2 HPWCJ27 655614 918  2-157 3605 Glu-10 to Gln-19, S0044: 2 Gln-22 to Lys-27, Pro-37 to Val-44. HPWCJ67 655560 919 236-373 3606 Leu-4 to Lys-9. S0044: 2 HPWCJ82 655577 920 215-415 3607 Ser-15 to Ser-22. S0044: 2 HPWDA73 514113 921 513-656 3608 Leu-43 to Leu-48. S0044: 1 and S0296: 1. 716228 2657  53-373 5344 HPWDA86 961529 922  15-164 3609 Gln-1 to Gly-8, H0648: 1 and S0044: 1. Lys-15 to Ser-23. HPWDD72 537333 923 193-342 3610 S0044: 2 and L0748: 1. HPWSB35 655713 924  74-268 3611 S0174: 2 HPZAB38 655591 925 138-254 3612 S0168: 2 HSWAC73 710354 926  2-409 3613 H0618: 1, H0546: 1 and H0040: 1. HSWAD39 705322 927 638-489 3614 L0777: 3, H0546: 2, L0803: 2, L0755: 2, L0637: 1, L0662: 1, L0794: 1, H0659: 1 and L0758: 1. HSWBD86 785439 928  1-150 3615 Ser-13 to Ser-19, L0800: 2, L0764: 2, Arg-37 to Gly-48. L0779: 2, H0546: 1, L0351: 1, L0769: 1, L0771: 1, L0438: 1, H0660: 1, L0439: 1 and L0592: 1. HSWBJ40 711066 929  2-307 3616 L0731: 3, H0545: 2, L0744: 2, L0021: 1, H0546: 1, L0769: 1, L0666: 1 and L0665: 1. HSWBO34 868007 930 611-826 3617 Gln-1 to Phe-10. L0777: 2, L0005: 1, H0546: 1, H0328: 1, L0761: 1, L0373: 1, L0527: 1, L0526: 1, L0754: 1, L0752: 1, L0755: 1, L0731: 1 and L0608: 1. HTEAA54 923070 931  34-513 3618 Gln-1 to Met-10, H0618: 2, H0038: 1 Met-16 to Lys-21, and H0616: 1. Thr-26 to Met-32. HTEAB52 537136 932  1-315 3619 Pro-53 to Asn-59. H0038: 3 HTEAD32 504353 933  50-187 3620 Arg-16 to Thr-28. H0038: 2 HTEAD95 961232 934  1-246 3621 Cys-5 to Ser-11, H0038: 3, L0747: 2, Pro-13 to Thr-18, H0618: 1, L0665: 1, His-28 to Arg-33, L0779: 1 and L0758: 1. Arg-40 to Arg-45, Pro-52 to Arg-57, His-66 to Gln-71. HTEAF07 835805 935  87-326 3622 L0758: 6, H0038: 3, H0616: 1, L0659: 1 and L0779: 1. 954433 2658 330-91  5345 Arg-1 to Pro-9. HTEAF26 537271 936 238-116 3623 Thr-5 to Glu-11. H0038: 11, L0758: 7, L0753: 2 and H0616: 1. HTEAG50 787500 937 199-104 3624 Val-6 to Lys-13. H0038: 1 and H0616: 1. HTEAK57 536769 938 423-202 3625 H0038: 12, H0616: 6, 10p12-p11.2 600964, H0593: 1, L0439: 1 and 602026 L0756: 1. HTEAL28 963538 939  3-626 3626 Gln-11 to Lys-24, H0038: 11, L0758: 7, His-60 to Leu-67, L0753: 2 and H0616: 1. Arg-85 to Ser-92. HTEAP91 966113 940  10-324 3627 Glu-13 to Trp-29, H0616: 4, L0758: 2 Thr-31 to Thr-44, and H0038: 1. Arg-54 to Ser-71. HTEAR84 783328 941  2-130 3628 H0038: 1 and H0616: 1. HTEAV43 927010 942 368-520 3629 Lys-17 to Lys-26. L0758: 3, H0616: 2 and H0038: 1. HTEAY67 679390 943 280-143 3630 Tyr-14 to Ser-19. L0758: 3, H0038: 2, L0794: 2 and L0779: 1. HTEAZ54 793441 944 286-501 3631 H0038: 2 and H0616: 1. HTEBC74 887782 945  1-321 3632 Pro-32 to Asn-39. AR054: 7, AR051: 2, AR089: 1, AR061: 0 L0663: 2, H0038: 1, H0672: 1 and L0779: 1. HTEBD35 967959 946  13-252 3633 Asn-28 to Cys-34. H0038: 2 HTEBD40 779134 947  3-152 3634 Pro-44 to Ser-50. H0038: 2 and H0616: 1. HTEBJ78 779265 948  3-971 3635 Ser-86 to Thr-97, H0038: 7, H0253: 1, Gln-104 to Pro-116, H0616: 1 and L0151: 1. Glu-168 to Ser-182, Thr-190 to Ser-198, Glu-208 to Tyr-213, Ser-230 to Val-237. HTEBP39 742218 949 373-540 3636 Glu-38 tO Ala-46. H0038: 2, H0328: 1 and H0616: 1. HTEBS30 693377 950 185-334 3637 Ser-39 to Val-49. H0038: 2 and H0616: 2. HTEBS77 953904 951 106-552 3638 Lys-1 to Asn-14. H0038: 1 and H0616: 1. HTEBS80 854052 952 201-359 3639 Lys-24 to Val-32. H0038: 2, H0040: 2 and L0758: 1. HTEBX62 508150 953 250-417 3640 H0038: 2 HTEBY08 960427 954  3-356 3641 Ile-11 to Trp-17, AR061: 1, AR089: 0 Arg-52 to Glu-65. H0038: 4 HTEBY15 526281 955  1-231 3642 Lys-66 to Thr-72. H0038: 2 HTRBY28 923026 956  1-546 3643 Arg-1 to Phe-12, H0616: 3 and H0038: 2. Met-34 to Lys-39, Lys-46 to Ser-56, Pro-72 to Lys-79, Lys-101 to Asp-107, Trp-139 to Lys-148. HTEBY41 711523 957 106-243 3644 H0038: 2 and H0616: 1. HTEBY61 967340 958  1-435 3645 Glu-9 to Arg-24. H0253: 1, H0038: 1 Arg-32 to Thr-40. and L0758: 1. HTEBZ21 958381 959  2-121 3646 H0038: 2 and H0616: 1. HTECA13 507053 960  1-204 3647 His-27 to Leu-39. H0038: 4 and H0616: 1. HTECA16 764416 961 111-389 3648 Glu-8 to Lys-17. H0038: 2 and L0779: 1. HTECA21 911369 962  1-387 3649 Asn-1 to His-6, AR061: 596, AR089: 427 Arg-117 to Cys-126. H0038: 2, H0616: 1 and L0439: 1. HTECA32 947605 963 792-406 3650 AR061: 49, AR089: 45 H0038: 2 HTECA51 708860 964  96-248 3651 H0038: 2, L0748: 2, L0749: 2, L0769: 1, L0776: 1, L0659: 1 and L0663: 1. HTECA83 870692 965  3-311 3652 Arg-22 to Tyr-28, H0038: 2 Ser-78 to Arg-87. HTECB21 921070 966  32-271 HTECC13 971673 967  61-270 3654 H0253: 1 and H0038: 1. HTECC20 963353 968  763-1005 3655 Arg-1 to Arg-11, H0038: 2 and H0616: 2. Arg-55 to Ser-70, Ser-76 to Gly-81. HTECC37 508143 969  1-147 3656 H0038: 1 and H0616: 1. HTECC38 844558 970 203-463 3657 Arg-15 to Leu-21, H0038: 4, H0616: 3, Ala-29 to Glu-34. L0758: 3 and L0779: 1. HTECC66 790937 971  84-287 3658 Asn-9 to Asn-16, H0038: 2 and H0616: 1. Asp-60 to Lys-68. HTECC80 796820 972  37-459 3659 Gln-18 to Trp-29, H0038: 2 and H0616: 1. Arg-46 to Val-52. HTECC85 508138 973  1-297 3660 Ala-10 to Thr-17, H0038: 2 Glu-19 to Glu-28, Thr-36 to Trp-44, Ile-47 to Gly-54, Ala-61 to Pro-69. HTECC96 959874 974 138-491 3661 Pro-6 to Cys-11, H0038: 2 Pro-77 to His-92. HTECD17 508108 975 154-411 3662 H0038: 2 HTECD18 973163 976  2-508 3663 Arg-1 to Ala-35, H0616: 14, H0038: 12, Gly-41 to Lys-61. H0618: 6, H0253: 5, L0758: 5, L0768: 4, H0411: 2, L0779: 2, L0151: 1, L0697: 1 and S0398: 1. HTECD36 518124 977  1-141 3664 Val-9 to His-36. H0038: 2 HTECD62 527207 978  3-161 3665 His-8 to Arg-15, H0038: 2, L0794: 2, Lys-19 to Lys-36. L0779: 2, H0616: 1 and L0758: 1. HTECD75 727422 979  3-275 3666 Gly-2 to Ala-8, H0616: 4, H0038: 2 Pro-10 to Thr-18, and L0758: 1. Pro-23 to Ser-34, Pro-45 to Asp-55. HTECE09 620494 980  2-286 3667 Ile-1 to Gly-9. H0038: 2 HTECE44 764830 981  2-286 3668 Ser-29 to Gly-35, H0038: 8, L0758:5, Asp-85 to Val-92. L0794: 4, H0616: 2, L0763: 1 and L0777: 1. HTECE45 790894 982  2-352 3669 L0766: 2, H0038: 1 and H0616: 1. HTECE69 522983 983  2-253 3670 Ile-1 to Arg-13. H0038: 2 Glu-25 to Leu-31. HTECE91 522984 984  3-296 3671 H0038: 2 HTEDF13 522964 985 123-257 3672 Glu-1 to Thr-6, H0038: 2 Glu-30 to Met-43. HTEDF23 522966 986  3-164 3673 Gly-2 to Arg-19, H0038: 2 Arg-24 to Gly-29, Lys-48 to Arg-54. HTEDF57 964734 987  2-418 3674 Asn-37 to Val-42, H0616: 2 and H0038: 1. Lys-82 to Glu-95, Glu-100 to Leu-105, Tyr-114 to Ser-120, Leu-129 to Lys-134. HTEDF76 522973 988 141-329 3675 H0038: 2 HTEDG16 925527 989  1-423 3676 Gln-61 to Cys-76, H0038: 2 Ile-95 to Asp-111. HTEDG34 761752 990 169-324 3677 H0616: 2 and H0038: 1. HTEDH21 522764 991  3-170 3678 Arg-1 to Glu-9, H0038: 3 Thr-42 to Arg-49. HTEDH22 522765 992  33-206 3679 H0038: 2, H0616:2, L0769: 1, L0794: 1, L0779: 1 and L0758: 1. HTEDH54 957762 993  1-411 3680 Asn-1 to Ser-14, H0038: 1 and H0616: 1. Glu-103 to Gly-108. HTEDI02 921243 994 121-705 3681 Glu-7 to Lys-13, AR061: 14, AR089: 12 Asp-29 to Leu-34, H0618: 2, H0634: 2, His-83 to Pro-91, H0038: 1, H0616: 1 and Ser-106 to Thr-111. L0758: 1. HTEDI16 932292 995  65-544 3682 Lys-18 to Arg-24, H0038: 2, H0616: 2, Pro-30 to Thr-35. L0740: 1 and L0758: 1. HTEDI82 536477 996 274-549 3683 Pro-20 to Thr-29. H0038: 3 HTEDJ04 519940 997  43-165 3684 H0038: 2 HTEDJ30 771404 998 -3-305 3685 L0740: 2, H0615: 1, H0428: 1, H0038: 1, L0662: 1, L0805: 1, L0661: 1 and L0751: 1. HTEDM08 960303 999  3-257 3686 Pro-31 to Ala-40. H0038: 2 and H0616:1. 8p12-p11.2 136350, 152760, 173370, 180100, 182900, 185430, 270800, 277700, 600617 HTEDO31 870711 1000 101-271 3687 Pro-1 to Trp-9, H0038: 2 Pro-25 to Lys-31. HTEDO51 530592 1001  3-164 3688 Arg-8 to Ser-20. H0038: 2 HTEDO59 964379 1002 130-231 3689 H0553: 1 and H0038: 1. HTEDP15 870675 1003  1-321 3690 H0038: 4 HTEDP31 870548 1004  68-337 3691 H0038: 1 and H0616: 1. HTEDP32 839532 1005 152-322 3692 Ser-9 to Ala-15. H0038: 2 HTEDP83 536821 1006  1-345 3693 H0038: 2 HTEDQ30 530589 1007  3-206 3694 AR061: 7, AR089: 3 L0758: 4, H0038: 2 and H0616: 1. HTEDQ72 795332 1008  53-475 3695 Pro-11 to Cys-28, H0616: 2, H0038: 1 Ser-41 to Leu-55, and L0758: 1. Pro-58 to Asn-63, Phe-67 to Ser-77. HTEDQ83 530586 1009 318-494 3696 H0038: 2 HTEDR71 761585 1010  88-171 3697 L0070: 2, H0038: 1 and H0616: 1. HTEDR91 530451 1011  53-238 3698 Ala-25 to Thr-32, H0038: 2 Lys-46 to Gly-52. HTEDU45 870708 1012 137-706 3699 Ile-2 to Gly-8. L0731: 6, L0758: 3, H0618: 1, H0038: 1 and L0794: 1. HTEDU48 832315 1013  2-730 3700 Lys-16 to Ser-22. H0038: 2 and H0616: 2. HTEDV02 921114 1014  3-164 3701 H0038: 2 HTEDX22 523959 1015 324-566 3702 Phe-37 to Ser-49. H0038: 3, L0438: 2, H0616: 1 and L0439: 1. HTEDX55 530452 1016 172-357 3703 Arg-1 to Asn-13, H0038: 2 Met-37 to Pro-47. HTEDY38 771505 1017  3-140 3704 Lys-28 to Lys-41. H0616: 2 and H0038: 1. HTEDY54 922964 1018 151-762 3705 Asp-67 to Asn-72, H0616: 3, L0759: 3, Pro-113 to Gly-121. H0038: 1, L0774: 1 and L0777: 1. HTEDY57 530580 1019 189-326 3706 Glu-11 to Gln-18. H0038: 2 HTEEA03 925399 1020  86-199 3707 His-1 to His-10. H0169: 2 and H0038: 1. HTEEB18 523962 1021 271-549 3708 Gln-9 to Asn-26. H0038: 2 and L0779: 1. HTEEB33 924818 1022 100-615 3709 His-19 to Lys-55, H0038: 5 and H0618: 1. Pro-72 to Ser-84, Ser-92 to Gly-104, Ser-111 to Asp-124, Thr-129 to His-141. HTEEC10 968517 1023  1-216 3710 Ser-1 to Gly-14, H0038: 2 and H0616: 1. Lys-28 to Ser-37. HTEEE65 530157 1024 202-384 3711 H0038: 2, L0758: 2 and L0779: 1. HTEEF31 924840 1025  88-345 3712 Pro-5 to Gln-13, H0038: 2 Thr-40 to Arg-45, Thr-52 to Gln-57, Phe-59 to Gly-64. HTEEH31 507814 1026  72-215 3713 Glu-9 to Val-15, H0038: 3 Glu-24 to Pro-30. HTEEU23 524059 1027  2-328 3714 Pro-8 to Leu-13. H0038: 2 HTEEU52 530199 1028 128-343 3715 Pro-32 to Asp-39, H0038: 1 and H0616: 1. Lys-57 to Gly-65. HTEEU88 698315 1029 106-240 3716 Ser-1 to Ser-8, H0038: 3 Ser-11 to Trp-19. HTEEU92 960127 1030 136-393 3717 Asn-2 to Lys-8, H0038: 2 and L0779: 1. Lys-16 to Asp-23, Arg-28 to His-51. HTEEV53 523957 1031 48-311 3718 Pro-24 to Ala-38. H0038: 2 HTEEW73 917206 1032 55-507 3719 H0038: 4, L0779: 2, L0758: 2 and L0618: 1. HTEEZ95 530095 1033  1-147 3720 H0038: 2 HTEFJ53 935982 1034 103-222 3721 H0038: 2 HTEFM31 771355 1035 298-429 3722 H0616: 2 and H0038: 1. HTEFN15 959854 1036 266-493 3723 H0038: 2 and H0616: 1. HTEFO32 529272 1037 150-73  3724 Phe-3 to Val-24. H0038: 2 HTEFO76 770270 1038 240-416 3725 H0038: 1 and H0616: 1. HTEFP14 659369 1039  3-260 3726 H0038: 4 and H0616: 1. HTEFP50 507219 1040 124-321 3727 Met-41 to Ile-46. L0776: 3 and H0038: 2. HTEFP61 711399 1041 119-352 3728 Arg-1 to Gln-22. H0038: 3 HTEFS60 836010 1042  1-168 3729 H0038: 1 and H0616: 1. HTEFU46 920604 1043 118-195 3730 H0038: 2 HTEFW55 787550 1044 273-662 3731 H0616: 4 and H0038: 1. HTEFW56 528019 1045  35-358 3732 Arg-1 to Asp-7, H0308: 2 and H0616: 1. Trp-24 to Cys-29, Ser-68 to Ile-73. HTEFW78 961061 1046  1-279 3733 Arg-3 to Leu-10, H0038: 1 and H0616: 1. Gln-34 to Glu-41, Ile-48 to Ser-53. HTEFX53 842047 1047 268-35  3734 Lys-1 to Thr-6. H0038: 3 HTEGA13 656077 1048  2-139 3735 H0038: 3 2q37.3 HTEGA17 964198 1049   2-1519 3736 Val-11 to Ser-19. H0038: 15, L0758: 5, H0618: 1, H0253: 1, L0151: 1 and L0768: 1. HTEGA43 715583 1050 190-306 3737 Lys-7 to Tyr-19. H0038: 2 HTEGA47 503300 1051  2-298 3738 Lys-6 to Lys-16, H0038: 2, L0779: 2 Arg-44 to Gln-51, and L0758: 2. Asn-57 to Phe-63, Ser-84 to Trp-89. HTEGD11 967698 1052 190-468 3739 Gln-6 to Ser-11, H0038: 1 and H0616: 1. Ser-15 to Gly-31, Ser-69 to Lys-93. HTEGE44 528017 1053  2-334 3740 Asn-1 to Pro-9. H0038: 2 HTEGF78 614242 1054 210-407 3741 Thr-1 to Ala-7. H0038: 2 HTGEF95 796660 1055  76-267 3742 Glu-25 to Trp-31, H0038: 1 and H0616: 1. HTEGG07 954115 1056 144-335 3743 H0038: 2 HTEGG61 528007 1057  2-217 3744 H0038: 2 HTEGK51 520046 1058  3-143 3745 Pro-13 to Lys-25. H0038: 2 HTEGM38 675087 1059  84-263 3746 Ala-15 to Tyr-24, AR089: 1, AR061: 0 11q25 602782 His-32 to Asp-39. H0038: 2 HTEGN63 520037 1060  1-183 3747 Asn-38 to Glu-47. H0038: 2 HTEGO05 932583 1061  3-884 3748 Pro-12 to Tyr-21. AR089: 1, AR061: 0 H0038: 2, L0745: 2 and H0616: 1. HTEGQ21 923059 1062 134-433 3749 Lys-28 to Lys-34, L0794: 15, H0616: 13, Glu-42 to Ser-48, H0038: 7, H0253: 1 and Ser-53 to Phe-63. L0758: 1. HTEGQ74 573865 1063  2-187 3750 Val-3 to Ser-8. H0038: 2 Cys-35 to Lys-45. HTEGR56 959871 1064  23-196 3751 Glu-8 to Ile-22. H0038: 2 HTEGR88 871611 1065 160-402 3752 H0038: 3 HTEGS16 527914 1066 131-352 3753 H0038: 2 HTEGS34 458520 1067 220-405 3754 Pro-35 to Glu-43, H0038: 2, L0758: 2, Gly-52 to His-57. H0294: 1 and H0616: 1. HTEGS93 506653 1068 155-355 3755 H0038: 2 HTEGT29 870638 1069 200-367 3756 Arg-1 to Thr-11. H0038: 3 and L0758: 1. HTEGT33 716783 1070 170-463 3757 H0038: 2 and L0758: 2. HETGU13 520041 1071  2-205 3758 Ala-1 to Tyr-14, H0038: 3 and H0616: 1. Thr-28 to Ser-60. HTEGU32 524053 1072  39-506 3759 Asn-44 to Asp-49, H0253: 8, H0038: 2, Ala-91 to Thr-97. H0179: 1, L0151: 1 and L0758: 1. HTEGU62 573885 1073  3-98 3760 H0038: 2 and H0616: 1. HTEGU93 764831 1074 194-595 3761 H0038: 8, L0758: 5, L0794: 4, H0616: 2, L0763: 1 and L0777: 1. HTEGV08 959888 1075 220-399 3762 Thr-14 to Gln-20, H0038: 2 Cys-23 to Glu-31. HTEGV60 822954 1076  80-418 3763 Tyr-12 to Phe-17, H0038: 1 and H0616: 1. Pro-32 to Asp-39. HTEGV84 870240 1077 234-449 3764 L0758: 8, H0038: 3, H0618: 2, H0616: 2 and H0253: 1. HTEGW41 573880 1078  1-243 3765 Ser-24 to Gln-30, H0038: 2 20q13.2-q13.3 118504, Asn-38 to Leu-44, 118504, Pro-46 to Glu-59. 131242, 139320, 139320, 139320, 139320, 602025, 602235 HTEGW94 794350 1079  1-351 3766 Gly-1 to Ile-7, H0038: 3 and H0616: 2. Pro-76 to Ala-82, Asn-86 to Ile-91. HTEGX74 783829 1080 200-556 3767 Asn-1 to Asp-9, L0758: 5, H0038: 3, Pro-17 to Cys-23. H0618: 1, H0616: 1, L0768: 1 and L0794: 1. HTEGY01 917214 1081  2-388 3768 Arg-87 to Tyr-92. H0038: 1 and H0616: 1. HTEGY85 573849 1082  91-312 3769 H0038: 2 HTEHB07 870707 1083  90-350 3770 Gly-23 to Lys-29. H0038: 5 HTEHC20 526704 1084 198-326 3771 H0038: 3 HTEHC47 973071 1085 719-84  3772 Ser-32 to Thr-37, AR050: 13, AR051: 13, Ser-161 to Cys-167. AR061: 3, AR054: 1, AR089: 1 L0758: 5, H0616: 2 and H0038: 1. HTEHC60 965998 1086  74-358 3773 Thr-44 to Ala-49, H0616: 3 and H0038: 2. Pro-60 to Arg-67, Asp-83 to Lys-95. HTEH78 573882 1087  2-256 3774 Ala-1 to Leu-9, H0038: 2 Thr-11 to Gly-19, Arg-31 to Thr-39, Gln-44 to Ser-58. HTEHE60 795264 1088  2-223 3775 Glu-57 to Pro-63. H0038: 1 and H0616: 1. HTEHE67 784926 1089 143-652 3776 Ala-2 to Asn-7, H0616: 2, H0038: 1 Glu-47 to Ile-62, and L0794: 1. Pro-71 to Trp-81, Gly-83 to Glu-88. HTEHE78 932312 1090 194-301 3777 Ser-1 to Arg-6, H0038: 3 and L0518: 1. HTEHE91 790342 1091  3-329 3778 Gln-1 to Asp-17, H0038: 2 Ser-51 to Arg-63, Pro-70 to Asp-78, Val-86 to Asn-93, Pro-100 to Asp-105. HTEHF13 667224 1092 201-332 3779 H0038: 2 anD H0616: 1. HTEHF66 836999 1093  2-436 3780 Ala-1 to Tyr-6, H0038: 4 Ala-88 to Asp-95. HTEHG44 933624 1094  57-695 3781 H0618: 1, L0023: 1, H0038: 1, H0616: 1 and L0758: 1. HTEHI06 935984 1095 262-534 3782 His-16 to Ser-22, L0758: 3, H0038: 2 Ala-77 to Glu-83. and L0747: 1. HTEHI14 526687 1096 216-458 3783 AR089: 5, AR061: 5 H0038: 4 HTEHI54 533960 1097  3-350 3784 Arg-1 to Gly-9, H0038: 2 Pro-50 to Ala-56. HTEHI62 922559 1098  1-282 3782 H0038: 2 and H0616: 1. HTEHI93 870629 1099  1-330 3786 Lys-9 to Pro-14. H0038: 3 HTEHJ64 530749 1100 136-249 3787 H0038: 2 HTEHK40 660875 1101  2-301 3788 Thr-16 to Met-39. H0038: 4 HTEHK70 771432 1102  2-274 3789 H0038: 2 HTEHK81 573866 1103  73-231 3790 Gln-2 to Leu-8, H0038: 2 Asp-42 to Gly-47. HTEHL96 573859 1104  3-404 3791 Glu-17 to Trp-27, H0038: 2 Leu-29 to Phe-34, Leu-56 to Arg-61, Asn-74 to Gly-83. HTEHO56 787521 1105  63-677 3792 Pro-9 to Asp-16, H0616: 2, H0038: 1 Gln-30 to Gln-36, and T0069: 1. Pro-69 to Ile-74, Val-78 to Pro-87, Ala-99 to Lys-112, Lys-117 to Gly-124. Lys-130 to Val-147, Ala-151 to Phe-156, Lys-180 to Asp-186. HTEHP02 920625 1106  66-215 3793 Glu-13 to Pro-27, H0038: 2 and H0616: 2. Leu-30 to Arg-37. HTEHP20 967443 1107  37-285 3794 Lys-5 to Glu-14, L0758: 3, H0038: 2, Arg-53 to Lys-60, H0616: 2 and L0794: 1. Met-77 to Gln-83. HTEHP50 531505 1108  7-126 3795 Arg-2 to Arg-17. H0038: 3 HTEHP60 573853 1109 210-434 3796 Glu-18 to Ser-26. H0038: 2 HTEHP67 751866 1110  1-135 3797 H0616: 2, H0038: 1 and L0758: 1. HTEHP80 573830 1111  3-320 3798 His-1 to Ser-8, H0038: 2 Asp-15 to Gln-50, Val-54 to Ser-67, Glu-76 to Lys-86, Ala-90 to Arg-105. HTEHR83 573841 1112  3-197 3799 Phe-43 to Glu-49. H0038: 2 HTEHS19 529280 1113  1-237 3800 Gly-70 to Gly-75. AR061: 5, AR089: 2 H0038: 2 HTEHU20 573813 1114  61-234 3801 H0038: 2, H0616: 2 and L0758: 2. HTEHU68 786378 1115 109-294 3802 Lys-1 to Arg-6, H0038: 1 and H0616: 1. Glu-23 to Arg-29. HTEHU73 870083 1116  76-276 3803 H0038: 2 HTEHV72 920610 1117  1-357 3804 Phe-32 to Asn-37, AR061: 8, AR089: 3 Phe-73 to Tyr-79. L0780: 3, L0759: 3, H0038: 2, L0779: 2, H0673: 1, L0803: 1, L0804: 1, L0666: 1 and H0648: 1. HTEHV86 785652 1118  2-466 3805 Ala-1 to Gly-8, H0038: 1 and H0616: 1. Ser-52 to Lys-58, Leu-81 to Asn-86. HTEHW03 924832 1119 181-453 3806 H0038: 2 HTEHW21 760552 1120  2-163 3807 H0038: 3, L0774: 2 and L0748: 1. HTEHX03 924826 1121  15-410 3808 Pro-4 to Lys-14, H0616: 3, H0038: 2 Thr-17 to His-22, and L0758: 1. Glu-25 to Arg-49, Pro-78 to Gly-85, Pro-120 to Phe-126. HTEHX32 772643 1122  3-215 3809 Arg-19 to Asn-24, L0758: 5, H0616: 3, Gly-30 to Gln-47. H0038: 2, L0794: 2 and H0253: 1. HTEHX51 668553 1123  84-212 3810 H0038: 2 HTEHX92 527167 1124  17-292 3811 H0038: 3 HTEIA60 859130 1125  2-343 3812 H0618: 2, H0038: 1 16q24.1 256850 and L0783: 1. HTEIA80 721831 1126  10-225 3813 H0038: 3 HTEIB14 963099 1127  3-308 3814 Gln-1 to Ser-10, AR061: 7, AR089: 4 Arg-18 to Thr-27, H0038: 4, H0616: 3, Arg-36 to Gln-65. L0747: 3, L0663: 2, L0758: 2, H0369: 1, H0428: 1, L0769: 1, L0542: 1, L0809: 1, L0666: 1, L0665: 1, L0743: 1, L0777: 1, L0731: 1 and S0456: 1. HTEIF40 958355 1128 173-457 3815 His-16 to Ser-21, H0038: 4 and H0616: 4. Ser-33 to Gly-60, Asp-87 to Glu-95. HTEIF68 573828 1129 139-249 3816 Ser-5 to Ile-17. H0038: 2 HTEIG32 699470 1130 135-326 3817 Leu-41 to Arg-55. H0038: 3 HEITH70 573826 1131  58-192 3818 H0038: 2 HTEIJ17 520113 1132  3-311 3819 Thr-65 to Thr-71, H0038: 3 and H0616: 1. Arg-92 to Glu-99. HTEIJ41 712520 1133  1-186 3820 Ser-7 to Ile-13, H0038: 1, H0616: 1 Arg-21 to His-26, and L0731: 1. Met-33 to Ser-49. HTEIJ73 958241 1134  40-255 3821 Pro-38 to Gln-54. H0038: 1 and H0616: 1. HTEIJ77 772402 1135  1-69 3822 H0038: 1 and H0616: 1. HTEIK11 967431 1136 149-409 3823 His-8 to Ala-24, H0038: 2 and H0032: 1. Thr-26 to Lys-33. HTEIK70 530454 1137  2-121 3824 Thr-24 to Thr-39. H0038: 2 HTEIK90 789121 1138 104-292 3825 Thr-41 to Lys-46, H0038: 1 and H066: 1. HTEIL07 953803 1139  42-443 3826 Glu-13 to Thr-27. AR061: 1, AR089: 0 L0758: 4, L0617: 2, L0794: 2, H0253: 1, H0038: 1, H0616: 1, L0789: 1 and L0779: 1. HTEIL48 523681 1140  83-271 3827 H0038: 3 HTEIL70 520045 1141  2-331 3828 Lys-15 to Lys-29, H0038: 2 Lys-36 to Thr-42, Val-48 to Thr-55, Gln-61 to Glu-80. HTEIL71 760551 1142  1-246 3829 Gly-1 to Gly-6, H0616: 2 and H0038: 1. Leu-28 to Asn-33. HTEIN68 753210 1143  74-346 3830 Gly-1 to Gly-6, H0038: 2 Pro-12 to Pro-17, Arg-27 to Pro-40. HTEIN95 839884 1144 159-545 3831 Asn-28 to Asn-33. H0038: 1 and H0616: 1. HTEIO02 920622 1145  3-347 3832 His-1 to Arg-11. H0038: 2 and H0616: 1. HTEIO12 653244 1146 152-334 3833 Phe-27 to Glu-39. H0038: 3 HTEIO28 573803 1147 159-356 3834 H0038: 2 HTEIP88 941155 1148  1-252 3835 Met-23 to Thr-30. AR089: 1, AR061: 0 H0038: 2 and H0253: 1. HTEIP92 523892 1149 194-370 3836 H0038: 4 HTEIQ74 765794 1150 232-462 3837 Lys-1 to Trp-10. H0038: 1 and H0616: 1. HTEIR33 928058 1151  41-472 3838 Arg-24 to Glu-38, H0616: 5, H0038: 2 Arg-46 to Ser-52, and H0253: 1. Pro-74 to Glu-80, Pro-118 to Ser-126. HTEIS65 573775 1152 300-458 3839 Glu-15 to Lys-29. H0038: 2 HTEIU75 779163 1153 305-547 3840 H0038: 1 and H0616: 1. HTEIU92 870652 1154  1-339 3841 Asp-5 to Arg-13, AR061: 3, AR089: 1 Thr-37 to Ser-45. H0038: 3 HTEIV54 922027 1155  2-712 3842 Ala-1 to Arg-9, H0616: 8, L0751: 6, Thr-14 to Trp-20, L0753: 6, L0776: 4, Arg-46 to His-53, L0758: 4, H0038: 3, Pro-58 to Glu-67, L0759: 2, S0222: 1, Tyr-80 to Pro-86, L0770: 1, L0779: 1, Ile-151 to Pro-160. L0731: 1 anD L0608: 1. HTEIV86 784657 1156  1-231 3843 Arg-16 to Ser-23, L0779: 2, H0038: 1 Cys-30 to Arg-35, and H0616: 1. Arg-51 to Arg-57, Gly-62 to Thr-68. HTEIW27 829698 1157 124-423 3844 H0038: 6 and H0616: 1. HTEIW37 573891 1158  68-352 3845 H0038: 2 HTEIX28 836011 1159 204-554 3846 His-33 to Gly-42. H0038: 2, L0758: 2, L0776: 1, L0809: 1, L0438: 1, H0658: 1 and L0756: 1. HTEIX85 864251 1160  2-226 3847 H0038: 2 HTEIY52 963536 1161  58-216 3848 Gly-43 to Ser-48. H0038: 1 and H0616: 1. HTEIY69 577783 1162  2-355 3849 Pro-7 to Pro-20, H0038: 2 Pro-33 to Leu-49. HTEIY80 955242 1163 188-460 3850 Thr-7 to Glu-16, H0038: 3 and L0758: 1. Lys-24 to Asp-34, Thr-40 to Glu-48, Leu-52 to Lys-57. HTEIZ76 523764 1164 144-386 3851 Leu-5 to Gly-13. H0038: 3, H0616: 1 and L0758: 1. HTEJB20 528015 1165 115-348 3852 H0038: 2 HTEJB25 530590 1166 216-377 3853 H0038: 2 HTEJB81 870644 1167  3-269 3854 Gly-47 to Ile-53. H0038: 2 HTEJC28 573774 1168 167-304 3855 Trp-14 to Glu-21, H0038: 2 and H0616: 1. Gly-29 tp Arg-36. HTEJC95 772989 1169 156-377 3856 H0616: 2 and H0038: 1. HTEJE15 908360 1170  2-319 3857 AR061: 4, AR089: 1 L0758: 7, L0794: 4, H0038: 2 and L0791: 1. HTEJE50 520049 1171  2-242 3858 Lys-9 to Lys-23, H0038: 2 Lys-30 to Lys-35. HTEJF45 942476 1172 122-643 3859 Ser-11 to Ala-19, AR089: 21, AR061: 15 Glu-24 to Leu-33, H0038: 2 Pro-37 to Pro-45. HTEJG24 526278 1173  79-276 3860 H0038: 2 HTEJJ43 774243 1174 148-384 3861 H0038: 2and H0616: 1. HTEJL21 573742 1175 415-173 3862 Gly-1 to Leu-9, L0758: 12, L0794: 6, Cys-15 to Arg-26, H0038: 2, L0789: 2, Pro-44 to Arg-50. L0752: 2, L0803: 1 and L0779: 1. HTEJM56 952255 1176 115-294 3863 Thr-17 to Ala-24. H0038: 1 and H0616: 1. HTEJN10 958389 1177  63-368 3864 Thr-1 to Trp-9, H0038: 2 and H0616: 1. Glu-12 to Arg-17, Pro-23 to Gln-40. HTEJN49 558383 1178  1-126 3865 H0038: 2 HTEJN96 573845 1179 169-354 3866 Thr-13 to Asn-19. H0038: 2 HTEJP10 914785 1180  2-418 3867 His-1 to Cys-7. H0038: 2 HTEJP66 916481 1181 475-645 3868 H0038: 1 and H0616: 1. HTEJP71 767955 1182  1-534 3869 Gln-12 to Ser-20. H0415: 1 and H0038: 1. HTEJT37 530596 1183  3-194 3870 His-1 to Ser-15, H0038: 2 and L0747: 1. Glu-29 to Lys-46, Pro-51 to Glu-63. HTEJT74 676254 1184  1-450 3871 Pro-14 to Ser-31. H0038: 2 HTEJU30 573823 1185  1-219 3872 Lys-1 to Ser-6, H0038: 2 and H0616: 1. Glu-22 to Ser-28, Ser-48 to Arg-56. HTEJV62 694525 1186  23-337 3873 Gly-11 to Thr-17. H0038: 2 HTEJX78 806395 1187  2-388 3874 Glu-2 to Thr-11, H0038: 2 Asn-35 to Gly-41, Thr-57 to Asn-63, Pro-73 to Glu-88, Pro-101 to Phe-110. HTEJY21 530156 1188  3-440 3875 Pro-9 to Trp-16, H0616: 3, H0038: 2 Trp-18 to Gly-25. and H0658:1. HTEJY27 685272 1189  1-252 3876 Arg-3 to Ala-10, L0758: 4, L0779: 3 and Asp-25 to Trp-31. H0038: 2. HTEJZ26 523818 1190  2-121 3877 Ala-1 to Pro-7, H0038: 2 and H0616: 1. Arg-13 to Ser-22. HTEKC07 920925 1191  76-402 3878 Arg-1 to Pro-12, H0038: 2 Trp-42 to Thr-47. HTEKC12 815975 1192  1-291 3879 Gly-1 to Trp-6, H0038: 2 Pro-12 to Ser-20. HTEKD04 519938 1193 147-338 3880 Arg-7 to Ser-12, H0038: 5 Trp-36 to Pro-60. HTEKE41 974044 1194 103-315 3890 Glu-29 to Ser-36, H0616: 2 and H0038: 1. Cys-49 to Thr-71. HTEKE46 870084 1195  753-1043 3882 Pro-22 to His-28. H0038: 2 and H0618: 1. HTEKE80 790381 1196 130-438 3883 Glu-19 to Tyr-36, H0616: 3 and H0038: 2. Glu-48 to Lys-53. HTEKF04 774260 1197  1-594 3884 Phe-1 to Gly-19, L0758: 5, H0616: 3 Gln-21 to Glu-31, and H0038: 2. Arg-79 to Lys-92, Ser-135 to Leu-145. HTEKF24 573750 1198 103-267 3885 Arg-43 to Phe-48. H0038: 2 1p13 102770, 188540, 600234, 601414, 601691, 601691, 601691, 601691, 601718, 602094 HTEKF35 573749 1199  27-233 3886 Pro-28 to Gly-33, H0038: 2 Asp-35 to Leu-51, Leu-61 to Thr-69. HTEKF68 772997 1200  1-291 3887 Glu-12 to Glu-19. H0038: 2and H0616: 1. HTEKI01 917176 1201  3-344 3888 H0038: 2 HTEKI70 503039 1202 257-682 3889 Ala-24 to Tyr-31, H0038: 3, L0758: 2, Gln-38 to Lys-43. H0253: 1, H0616: 1, L0794: 1, L0803: 1, L0748: 1 and L0588: 1. HTEKJ48 530588 1203  2-247 3890 Pro-7 to Gln-16, H0038: 2 Arg-19 to Gly-32, Pro-34 to Glu-45, Phe-56 to Leu-65. HTEKM14 745257 1204  1-264 3891 Lys-34 to Ala-42. H0038: 3 and H0616: 1. HTEKO49 723148 1205  3-251 3892 Pro-8 to Thr-14. H0038: 1 and H0616: 1. HTEKQ26 870627 1206  31-165 3893 H0038: 2 HTEKQ85 784444 1207 348-569 3894 Lys-62 to Ser-67. H0038: 1 and H0616: 1. HTEKR75 870555 1208 139-318 3895 H0038: 1 and H0616: 1. HTEKS15 529273 1209 290-427 3896 H0038: 2 HTEKS20 845714 1210  3-569 3897 Pro-9 to Arg-14, AR061: 2, AR089: 1 Phe-34 to Ile-39, L0758: 14, H0038: 5, Arg-41 to Lys-47, L0774: 4, L0794: 2 and Leu-49 to Gly-55, H0616: 1. Lys-104 to Lys-110, Asp-119 to Gly-124. HTEKS21 506651 1211 113-346 3898 Val-1 to Val-8, H0618: 3, H0253: 1 Arg-36 to Pro-41, and H0038: 1. Thr-50 to Leu-55. HTEKS76 767658 1212 166-399 3899 Ser-9 to Ser-17, H0038: 1 and H0616: 1. Leu-48 to Cys-54. HTEKX06 935945 1213  87-263 3900 Gly-46 to Glu-58. H0038: 1 and H0616: 1. HTEKX08 959876 1214 118-375 3901 Glu-37 to Asp-46. L0758: 10, H0038: 3, L0794: 2, H0618: 1, H0253: 1 and H0616: 1. HTEKX28 920927 1215 108-257 3902 H0038: 2 and L0758: 1. HTEKX70 573700 1216  68-259 3903 H0038: 2 HTEKZ50 524054 1217  98-280 3904 Ile-9 to Asn-20, H0038: 2 Ala-22 to Asp-29. HTELA50 774268 1218  49-195 3905 Lys-8 to Lys-14. H0616: 4, L0803: 1 and L0731: 1. HTELD47 934272 1219 165-536 3906 H0616: 3 and L0519: 2. HTELD82 779315 1220  79-267 3907 Arg-1 to Ser-6. H0616: 2 HTELE10 963563 1221 157-438 3908 H0616: 3 HTELE41 791743 1222 260-475 3909 Ala-8 to Ser-13. H0616: 5 HTELG47 757740 1223 279-455 3910 Pro-2 to Asp-7. H0038: 1 and H0616: 1. HTELG57 870621 1224  1-318 3911 Val-17 to Val-23, H0616: 2 and H0038: 1. Phe-34 to Tyr-46, Thr-62 to His-67. HTELG80 773018 1225  3-107 3912 Val-1 to Thr-12. H0616: 2 HTELH44 766462 1226 351-542 3913 Gln-9 to His-21. H0038: 1, H0616: 1 and L0745: 1. HTELI03 923071 1227 421-588 3914 Glu-27 to Thr-34. H0038: 1 and H0616:1. HTELI51 806403 1228 318-554 3915 H0616: 2 and L0749: 1. HTELJ89 966134 1229  86-361 3916 Asn-1 to Gln-7. H0616: 4 and L0758: 3. Phe-27 to Gly-38, Pro-61 to Gly-68. HTELK14 794339 1230  3-449 3917 H0038: 1 and H0616: 1. HTELK50 870552 1231  9-239 3918 Arg-21 to Phe-28. H0616: 2 HTELK68 923055 1232 107-349 3919 H0616: 2 HTELL48 783824 1233 181-294 3920 H0616: 4 HTELL51 952267 1234 394-648 3921 H0616: 2 HTELL90 952269 1235 357-626 3922 Asn-56 to Ser-66. H0616: 3 and L0779: 1. HTELM89 786268 1236  75-302 3923 Asp-19 to Lys-24. H0038: 2 and H0616: 1. 18 HTELO20 926910 1237 117-434 3924 Leu-21 to Gly-26, H0616: 11 and H0038: 1. His-101 to Trp-106. HTEL051 931120 1238  2-166 3925 Ser-21 to Aer-29. H0616:4 Ala-43 to Asn-49. HTELO73 761806 1239  56-232 3926 Lys-1 to Cys-7, H0038: 1 and H0616: 1. Lys-16 to Glu-21, Ser-23 to Thr-37, Pro-40 to Ser-47, Glu-49 to Arg-59. HTELO93 934344 1240  1-204 3927 Asn-6 to Ser-12. H0616:2 HTELP27 921621 1241  3-470 3928 Pro-1 to Val-16, and L0754: 1. Asn-47 to Ala-61, Arg-89 to Leu-94. HTELQ41 922634 1242  97-462 3929 H0616: 3 HTELQ87 761768 1243  36-344 3930 Tyr-1 to Leu-7, H0616: 2 and H0038: 1. Phe-51 to Asp-60. HTELR90 826531 1244  2-451 3931 Arg-29 to Leu-40, H0616: 2 Gly-50 to Gln-55, Thr-73 to Ile-83, Lys-90 to Lys-95. HTELT72 761598 1245  2-235 3932 Thr-7 to Asp-12, H0616: 4, L0774: 2, Leu-20 to Ile-29, H0618: 1, L0665: 1 and Ser-54 to Ser-64, L0747: 1. Met-66 to Gly-77. HTELT83 780619 1246  3-521 3933 Lys-50 to Glu-55. H0616: 4 HTELU01 915339 1247  3-173 3934 Lys-1 to Lys-9. H0616: 2 HTELV06 934302 1248  37-240 3935 Lys-57 to Gly-63. H0616: 2 and L0758: 1. HTELV10 963576 1249 106-270 3936 Asp-1 to Trp-11, H0616: 2 Ser-49 to Lys-55. HTELV26 796832 1250 172-303 3937 Thr-17 to Leu-22. L01758: 16, H0038: 1 and H0616: 1. HTELV43 870615 1251  2-448 3938 Gly-2 to Ile-19, H0038: 1 and H0616: 1. Lys-22 to Ala-31, Asp-49 to Asn-56. HTELV86 910946 1252  1-927 3939 Thr-5 to Ser-11, AR089: 7, AR061: 6 Asp-78 to His-85, H0616: 4, H0038: 1, Ser-153 to Ser-162, L0745: 1 and L0779: 1. Glu-221 to Ala-234, Gly-247 to Glu-252. HTELW29 952241 1253  3-293 3940 Ala-21 to Trp-26, H0616: 4, H0038: 2, Arg-64 to Val-83. L0768: 1 and L0779: 1. HTELW62 870596 1254  71-271 3941 Cys-2 to Glu-9. H0616: 2 and L0758: 1. HTELX52 963506 1255  3-302 3942 Gln-3 to Gln-13. H0616: 2 HTELX72 761599 1256  25-117 3943 H0038: 1 and H0616: 1. HTELY64 764834 1257 140-283 3944 Thr-18 to Gly-25. H0616: 2 HTELZ07 952268 1258  94-312 3945 Lys-32 to His-41. H0038: 1 and H0616: 1. HTELZ89 786424 1259 171-353 3946 Ser-46 to Thr-53. H0616: 2 HTEMA54 911666 1260  22-1167 3947 Gly-23 to Asn-30, AR089: 19, AR061: 13 9q31 109400, Arg-45 to Lys-50. H0618: 14, H0253: 12, 132800, H0038: 11, H0616: 2, 132800, L0794: 1, L0779: 1 and 186855, L0758: 1. 223900, 253800, 253800, 278700, 602088 HTEMB26 827055 1261  75-143 3948 Thr-6 to Lys-23. H0616: 2 HTEMB28 870614 1262 103-342 3949 Tyr-4 to Tyr-23. H0616: 2 Ala-20 to Ser-28, Val-44 to Arg-54. HTEMB34 870589 1263 141-371 3950 Leu-25 to Asn-32, H0616: 3 Ala-49 to Phe-56, Arg-60 to Lys-69. HTEMB72 761602 1264  1-306 3951 H0038: 1 and H0616: 1. HTEMB83 775593 1265  2-292 3952 Lys-49 to Lys-56. L0758: 9, L0794: 3, H0038: 2, H0616: 2, L0790: 1 and L0779: 1. HTEMC18 924727 1266  1-453 3953 Gln-16 to Gly-27, H0253: 3, H0618: 2 Glu-59 to Gly-65, and H0616: 1. Ser-107 to Arg-113. HTEMC75 848193 1267  58-240 3954 Gln-15 to Arg-21. H0038: 1 and H0616: 1. HTEMD10 963546 1268  1-270 3955 Gly-1 to Glu-8, H0616:2 and L0758: 2. Glu-16 to Ser-22, Asp-43 to Gly-49, His-65 to Met-70, Lys-79 to Gln-90. HTEMD73 761783 1269  2-310 3956 Ala-20 to Thr-44. H0038: 2 and H0616: 2. HTEMF08 958386 1270  3-116 3957 H0616: 2 HTEMJ34 786377 1271 248-496 3958 H0616: 6 and L0758: 1. HTEMJ54 963531 1272 388-570 3959 H0616: 4, H0038: 1 and L0748: 1. HTEMK03 923066 1273  45-359 3960 Pro-11 to Gly-21, H0038: 1 and H0616: 1. Pro-65 to Ser-71. HTEMM80 888686 1274 353-631 3961 Pro-32 to Gly-40, H0616: 5, H0038: 2, His-54 to Glu-74. L0779: 1 and L0758: 1. HTEMN08 958374 1275 10-96 3962 Tyr-16 to Ser-25. H0616: 2 HTEMN95 789113 1276  54-251 3963 H0038: 1 and H0616: 1. HTEMO14 880634 1277  2-319 3964 H0616: 2 and H0038: 1. HTEMO85 771434 1278 166-276 3965 Phe-7 to Glu-12, H0616: 3 Leu-22 to Tyr-28. HTEMP48 767863 1279  1-159 3966 Gln-29 to Gly-34. H0616: 3 and H0038: 1. HTEMP49 932319 1280  3-629 3967 Arg-8 to Ser-15, H0038: 10, L0758: 7, Ser-21 to Trp-40, L0768: 6, H0253: 4, Glu-63 to Trp-74, H0616: 2, L0772: 1, Ser-76 to Ser-81, L0773: 1, L0779: 1 and Asp-83 to Asp-96, L0731: 1. Glu-125 to Ser-131, Leu-198 to Leu-206. HTEMR65 909280 1281  2-340 3968 Ser-7 to Asp-13, AR089: 17, AR061: 13 Leu-49 to Asn-54, L0794: 2, L0752: 2, His-62 to Tyr-68. H0616: 1, L0763: 1, L0766: 1, L0664: 1, H0670: 1 and L0758: 1. HTEMS10 963527 1282 102-371 3969 Arg-1 to Arg-8, H0038: 1, H0661: 1 Leu-44 to Ala-50, and L0758: 1. Ser-58 to Ile-68. HTEMS48 832506 1283  45-203 3970 Ser-16 to His-24. H0038: 1 and H0616: 1. HTEMT06 934338 1284  2-268 3971 Ile-14 to Asn-22, L0758: 4, H0038: 1, Pro-28 to Gln-43, H0616: 1 and L0779: 1. Pro-49 to Arg-56, Pro-62 to Ser-78, Thr-81 to Glu-89. HTEMT89 922999 1285  2-160 3972 Glu-36 to Val-53. L0758: 3 and H0616: 2. HTEMU17 789623 1286 112-273 3973 Arg-21 to Pro-26. H0616: 2, L0749: 2 and H0038: 1. HTEMU54 870618 1287  43-189 3974 Arg-18 to Lys-24, H0616: 3 Thr-29 to Ile-34. HTEMX92 913795 1288  23-514 3975 Gly-82 to Lys-89. AR061: 6, AR089: 3 H0616: 2 and H0038: 1. HTEMY30 870662 1289  46-231 3976 Arg-32 to Gly-37. H0038: 1, H0616: 1 and L0759: 1. HTEMZ04 927021 1290 162-377 3977 H0616: 2 HTENA22 870601 1291  1-294 3978 Pro-20 to Ala-32, H0038: 1 and H0616: 1. Arg-46 to Val-51. HTENB03 923050 1292  24-338 3979 Ser-29 to Val-39. H0616: 3 HTENC22 775544 1293 243-497 3980 Gln-29 to Leu-34, H0616: 2 and L0109: 1. Arg-36 to Leu-44, Glu-58 to Ser-64, Ser-67 to Pro-85. HTENF08 958378 1294 380-574 3981 Ala-6 to Ala-12. H0038: 1 and H0616: 1. HTENF95 795316 1295 111-347 3982 Glu-69 to Leu-79. H0038: 1, H0616: 1 and S0152: 1. HTENG66 840151 1296  3-308 3983 Asn-2 to Glu-14, H0253: 3, H0038: 1 Pro-17 to Lys-27, and H0616: 1. Gly-42 to Ser-59, Cys-70 to Lys-81. HTENG93 967432 1297  1-102 3984 His-7 to Ser-12. H0038: 1 and H0616: 1. HTENH86 784798 1298 182-436 3985 Ile-28 to Ser-36. H0616: 2, H0038: 1 and L0758: 1. HTENI58 917213 1299  41-589 3986 Asn-17 to Asn-30, AR089: 30, AR061: 13 Glu-37 to Lys-56, L0794: 25, L0758: 4, Asp-64 to Gln-69, H0038: 3, H0616: 2, Gly-77 to Ser-95, L0779: 2, L0768: 1 and Lys-109 to Asn-114, L0790: 1. Arg-158 to Ser-183. HTENJ28 968135 1300  1-948 3987 Thr-6 to Arg-17. H0038: 7, H0124: 1, H0040: 1, H0616: 1 and L0779: 1. HTENJ76 767838 1301  3-443 3988 Thr-17 to Ala-25, H0253: 1 and H0616: 1. 11q13.2-q13.3 133780, Pro-40 to Glu-46, 151400, Asn-76 to Glu-81, 602078 Gln-90 to Lys-104. HTENK06 835851 1302 249-566 3989 Gly-23 to Pro-32. H0616: 3 and H0618: 1. HTENK69 844557 1303 192-509 3990 Arg-15 to Leu-21, H0038: 4, H0616: 3, Ala-29 to Glu-34, L0758: 3 and L0779: 1. Pro-40 to Trp-49, Ser-82 to Ala-97. HTENO12 917032 1304  76-1467 3991 Gly-29 to Glu-39, H0616: 6, H0618: 3, Gly-105 to Lys-117, H0253: 3 and H0038: 3. Gln-135 to Leu-142, Pro-180 to Ser-186, Gln-202 to Ser-207, Gln-214 to Asp-220, Gly-246 to Thr-255. HTENO50 969213 1305 190-618 3992 Asn-1 to Glu-6, H0038: 1 and H0616: 1. Gln-9 to Gly-15, Gln-18 to Arg-40. HTENP54 787535 1306  17-208 3993 Arg-13 to Leu-18. H0616: 17 and L0758: 1. HTENP80 775387 1307  2-496 3994 Asp-16 to Leu-22, H0038: 1 and H0616: 1. Met-37 to Thr-42, Glu-55 to Gly-68. HTENQ05 928244 1308  1-654 3995 His-23 to Ser-34, H0038: 2, H0616: 1 His-77 to Glu-82. and L0758: 1. HTENR10 963530 1309  24-380 3996 Gly-40 to Ala-45, H0038: 1 and H0616: 1. Arg-65 to Thr-75. HTENR74 764828 1310  1-456 3997 Gly-1 to Pro-15. H0038: 2 and H0616: 1. HTENR93 920834 1311 201-659 3998 Glu-49 to Ala-55, H0328: 1, H0038: 1 Cys-57 to Ser-85, and H0616: 1. Ser-90 to Glu-97, Ile-108 to Lys-114, Val-117 to Asn-127. HTENS22 785996 1312  3-440 3999 Met-2 to Asn-16, H0038: 1, H0616: 1 Gln-30 to Gln-35, and L0748: 1. Met-42 to Gln-48, Ser-54 to His-60, Pro-63 to Ser-69, Leu-101 to Gln-118, Gly-139 to Pro-146. HTENS43 784936 1313 226-756 4000 H0616: 5, H0038: 3, H0253: 1, L0769: 1, L0794: 1, H0521: 1, L0748: 1, L0779: 1 and L0758: 1. HTENS91 870515 1314 387-725 4001 Trp-1 to Gln-10. H0616: 2 and L0517: 1. HTENV57 944416 1315  99-617 4002 Gly-5 to Arg-10, AR061: 7, AR089: 3 Arg-18 to Ser-24, H0616: 5 and H0037: 1. Glu-35 to Asn-42, Lys-72 to Gln-82, Tyr-90 to Lys-96, Lys-112 to Arg-123, Asp-141 to Met-146. HTENW53 907717 1316  1-243 4003 Arg-6 to Asp-13, H0038: 2, H0616: 2 Lys-70 to Trp-76. and L0758: 2. HTENX77 771409 1317 168-359 4004 Glu-1 to Lys-11. L0758: 10, L0439: 6, H0616: 2, L0803: 2, L0756: 2, L0455: 1, H0038: 1 and L0438: 1. HTENY21 870587 1318 383-553 4005 Ala-17 to Ser-22. H0038: 1 and H0616: 1. HTENY35 884043 1319   2-1009 4006 Gln-1 to Ser-19, H0616: 3 Glu-29 to Lys-35, Leu-58 to Phe-68, Cys-100 to Arg-107, Cys-113 to Cys-119, Phe-124 to Asn-139, Leu-157 to Glu-163, Ile-174 to Ile-180, Pro-195 to Pro-204, Gly-228 to Glu-250, Ile-260 to Asp-266, Thr-273 to His-279, Cys-281 to Gly-291. HTENZ16 917185 1320 203-454 4007 L0779: 9, L0758: 9, L0665: 8, H0616: 4, L0663: 4, H0038: 3, L0755: 3, L0717: 1, L0768: 1, L0666: 1, H0659: 1, H0670: 1, L0748: 1 and L0749: 1. HTENZ33 870591 1321 102-377 4008 Gln-24 to Glu-34, H0038: 1 and H0616: 1. Ala-58 to Ser-64. HTENZ72 773024 1322  2-400 4009 Met-56 to Pro-67, H0616: 2 and H0038: 1. Ser-82 to Tyr-87, Pro-111 to Ala-121. HTEOA90 787516 1323  24-329 4010 Arg-20 to Gln-27, H0038: 1 and H0616: 1. Arg-37 to His-42, Pro-46 to His-55. HTEOD34 812307 1324 129-428 4011 Tyr-3 to Cys-9, H0616: 2 and H0038: 1. Thr-20 to Ile-25, Gly-60 to Arg-67. HTEOE61 918635 1325 247-411 4012 H0616: 2 and H0038: 1. HTEOF31 793202 1326 258-632 4013 Gly-2 to Glu-13, H0038: 1 and H0616: 1. Val-40 to Cys-79. HTEOF80 847224 1327  2-262 4014 Val-17 to Arg-23, AR061l 7, AR089: 3 Xp22 300000, Tyr-28 to Ser-34, H0616: 3 300066, Thr-41 to Cys-47. 300077, 300310, 301220, 302350, 304050, 304110, 306100, 309530, 309585, 312040 HTEOF85 768583 1328 113-364 4015 H0663: 1, H0644: 1, H0038: 1 and H0616: 1. HTEOF91 918571 1329  27-164 4016 Arg-31 to Asp-37. H0616: 2 HTEOI36 870575 1330  3-410 4017 Pro-17 to Ala-25, AR089: 36, AR061: 21 Lys-33 to Arg-40, H0038: 7, H0618: 1, Arg-62 to Lys-68, H0253: 1 and H0616: 1. Ala-79 to Val-93, Lys-106 to Asp-113. HTEOI53 810333 1331  11-295 4018 Arg-1 to Ile-8, H0038: 1 and H0616: 1. Tyr-12 to Gly-29, Lys-34 to Ala-64, Lys-77 to Glu-91. HTEOK02 918590 1332 121-408 4019 H0616: 2 and H0038: 1. HTEON29 815852 1333  2-520 4020 Pro-27 to Ala-35. AR061: 6, AR089: 3 H0038: 4, L0758: 3, H0616: 2, L0794: 2, L0747: 2, L0803: 1, L0789: 1 and L0590: 1. HTEON67 654114 1334 107-271 4021 H0038: 2 and H0616: 1. HTEOU45 915138 1335 320-529 4022 H0616: 22 HTEOV90 870532 1336  22-438 4023 Pro-14 to Phe-23, L0766: 5, L0803: 3, Lys-111 to Lys-133. H0616: 2, L0777: 2, L0470: 1, L0761: 1, L0764: 1, L0804: 1, L0805: 1, L0776: 1, L0789: 1 and L0750: 1. HTEOW02 918475 1337  3-266 4024 Ser-30 to His-36, H0616: 2 Arg-54 to Arg-59. HTEOW39 870566 1338  2-445 4025 Gly-38 to Val-44. AR089: 17, AR061: 14 H0616: 2 HTEOW85 969682 1339  2-490 4026 Arg-1 to Ala-13, H0618: 3, H0616: 2 Arg-99 to Arg-104, and H0253: 1. Thr-117 to Gln-124, Asn-132 to Gln-137, Thr-145 to His-155. HTEPA08 958391 1340 147-605 4027 Tyr-34 to Glu-43. L0758: 9, H0038: 1. H0616: 1 and S0042: 1. HTEPA27 872923 1341  43-393 4028 Pro-77 to Ser-83. H0616: 3, L0747: 2, L0794: 1, L0803: 1 and L0779: 1. HTEPB66 772949 1342 204-515 4029 Asp-35 to Gly-40. H0616: 3, L0758: 2, L0794: 1 and L0366: 1. HTEPB84 782248 1343 161-568 4030 Leu-2 to Gly-11. H0616: 2 and H0038: 1. HTEPC76 767824 1344 140-328 4031 Pro-10 to Asn-16, H0616: 4, L0779: 1 Asn-38 to Arg-44. and L0758: 1. HTEPC87 883021 1345 126-497 4032 Cys-5 to Thr-14. H0616: 2 HTEPD06 933299 1346  2-193 4033 His-7 to Gly-17, H0616: 4, L0756: 2 Gly-25 to Leu-36. and H0038: 1. HTEPE28 932576 1347  2-640 4034 Asn-30 to Lys-43, AR061: 5, AR089: 2 Pro-58 to Glu-65, H0369: 1, H0038: 1, Arg-77 to Asn-85. H0616: 1, L0593: 1 and L0595: 1. HTEPG15 812303 1348  3-395 4035 Gln-1 to Asn-9, L0752: 1, H0618: 1, Pro-14 to Leu-20, H0616: 1, L0769: 1, Leu-42 to Gly-47, L0803: 1, L0789: 1, Gln-56 to Arg-61, L0439: 1, L0758: 1 and Pro-109 to Ser-114, L0698: 1. Lys-119 to Thr-131. HTEPH01 915301 1349  25-447 4036 Thr-2 to Ser-12, H0616: 3 and H0038: 1. Arg-60 to Leu-67, Ala-72 to Thr-77, Pro-82 to Lys-91, Gly-96 to Ser-101, Glu-110 to Pro-118, Gln-124 to Leu-129, Gln-132 to Ser-138. HTEPJ09 956200 1350  305-1216 4037 Arg-1 to Asn-11, H0616: 2 and L0758: 1. His-40 to Arg-45. HTEPJ19 918599 1351  37-345 4038 Arg-1 to Ser-9. H0616: 2 HTEPJ79 774212 1352  27-122 4039 H0038: 1 and H0616: 1. HTEPK40 939675 1353 209-631 4040 Gly-5 to Pro-15, H0616: 5, L0758: 5 Ser-23 to His-32. and H0038: 1. HTEPM33 870561 1354  1-735 4041 Pro-8 to Gly-26, AR061: 25, AR089: 5 Cys-54 to Cys-66, L0758: 3, H0616: 2, Gly-73 to His-85. H0038: 1 and L0779: 1. HTEPM52 806471 1355 171-326 4042 H0616: 2 HTEPN07 952243 1356  3-311 4043 Leu-12 to Pro-17, H0616: 2 and H0038: 1. Pro-24 to Gly-29, Ser-34 to Gly-39. HTEPP23 836572 1357  1-192 4044 Asn-6 to Asp-16. H0616: 2, L0779: 2, H0038: 1 and L0758: 1. HTEPP29 917207 1358  1-372 4045 Gly-33 to Gly-38, H0038: 1 and H0616: 1. Gln-61 to His-66. HTEPP30 947107 1359  12-641 4046 Ala-35 to Glu-41, H0616: 3 and H0038: 1. Ile-54 to Glu-74, Lys-80 to Leu-87. HTEPP32 785803 1360  3-866 4047 Gln-8 to Cys-17, H0616: 4 and H0038: 3. Cys-20 to Gln-26, Thr-61 to Lys-68, His-75 to Gly-83, Asn-88 to Gln-104, Pro-118 to Leu-126, Gln-131 to Glu-138. HTEPP92 790869 1361  3-545 4048 Lys-86 to Lys-91, H0038: 1 and H0616: 1. LyS-107 to Lys-139, Leu-155 to Asn-162. HTEPR90 787499 1362  1-168 4049 H0038: 2 and H0616: 2. HTEPT25 870509 1363  1-238 4050 Gly-42 to Gly-47. H0616: 2 HTEPT75 870637 1364  42-518 4051 Pro-66 to Ser-74. H0616: 2 and H0038: 1. HTEPU01 915134 1365 533-670 4052 H0616: 2 HTEPV02 917406 1366  1-471 4053 Ser-9 to Ser-17, AR061: 6, AR089: 2 Phe-21 to Leu-45. H0616: 3, L0758: 2, L0768: 1, L0792: 1 and L0779: 1. HTEPX32 870698 1367  91-699 4054 Ser-10 to Gly-15, AR089: 11, AR061: 2 Pro-20 to Ser-27, H0038: 6, H0616: 6, Glu-34 to Gly-41, L0794: 4, L0768: 1 and Ala-45 to Trp-50, ` L0758: 1. Pro-79 to Gly-88. HTEPZ10 963433 1368 274-543 4055 Pro-9 to Ser-19, H0616: 2 and L0758: Pro-51 to Asp-57. 2. HTEPZ18 888470 1369  50-52 4056 Lys-2 to Gly-11. H0618: 1 and H0616: 1. HTEQB03 922941 1370  2-151 4057 Pro-30 to Cys-35, H0616: 4 Thr-41 to Ser-47. HTEQD40 915198 1371  2-490 4058 Met-11 to Lys-28. L0758: 7, H0618: 1, H0616: 1, L0794: 1 and L0779: 1. HTEQD69 918579 1372 133-321 4059 Thr-39 to Asn-45. H0616: 2 and H0038: 1. HTEQE87 958354 1373 205-633 4060 His-16 to Ser-21, H0038: 2 and H0616: Val-30 to Asn-40, 1. Leu-54 to Pro-64. HETQG56 881004  -426 4061 Pro-31 to Glu-45, H0616: 3 and H0038: Ala-52 to Lys-58, 1. Met-78 to Lys-89. HTEQI54 853971 1375 189-422 4062 Thr-1 to Asn-6, H0616: 2, L0803: 1 Pro-11 to Phe-19, and L0774: 1. Arg-21 to Asn-27. HTEQJ14 870525 1376 158-424 4063 H0038: 2 and H0616: 1. HTEQJ42 806495 1377  90-308 4064 Gln-4 to Ser-9, H0038: 1 and H0616: Ala-23 to Glu-29, 1. Phe-65 to Ser-71. HTEQO81 806504 1378  -144 4065 H0038: 1 and H0616: 1. HTEQP45 966141 1379  -141 4066 Lys-1 to Phe-10. H0616: 4 HTEQQ82 932301 1380 254-24  4067 Asp-5 to Asp-14. H0616:3 and L0758: 1. HTEQR15 939641 1381 108-590 4068 Thr-17 to Leu-22. AR089; 10, AR061: 3 H0253: 8, H0038: 4, H0616: 3, H0618: 2, L0758: 2 and L0779: 1. HTEQR94 966486 1382  77-388 4069 Asn-83 to Ser-88. L0758: 6, H0616: 2 and L0794: 2. HTEQT63 924799 1383  193-1311 4070 L0758: 3, H0038: 1 and H0616: 1. HTLAB19 530577 1384  3-281 4071 Asp-32 and Gln-37. H0253: 2 HTLAB44 530579 1385  3-266 4072 Ala-6 to Gly-25. H0618: 4 and H0253: 3. HTLAB73 575019 1386  1-333 4073 Gly-42 to Arg-47. H0253: 2 HTLAC81 679414 1387  2-163 4074 Leu-2 to Cys-8, H0253: 3 Gly-32 to Arg-39. HTLAC87 546469 1388  23-154 4075 Ala-1 to Arg-6, H0038: 164, H0253: Met-14 to Thr-32. 42, H0150: 2, H0549: 1 and S0042: 1. HTLAD21 761758 1389  2-298 4076 Ser-5 to Asn-12, L0758: 4, H0253: 2, Leu-63 to Gly-71. H0616: 2, L0649: 1, L0666: 1, L0663: 1 and L0780: 1. HTLAD38 421550 1390  86-529 4077 Phe-12 to Leu-22, L0758: 5, H0253: 4, Ser-26 to Tyr-32, L0794: 4, H0618: 2, Phe-53 to Asn-59, H0038: 1, H0616: 1 and Tyr-68 to Leu-73, L0768: 1. Gln-96 to Gly-102. HTLAF84 836390 1391  1-444 4078 Pro-32 to Thr-48, H0253: 2 and L0777: Arg-102 to Pro-109. 1. HTLAV67 530742 1392  36-221 4079 Ser-39 to Gly-45. H0253: 3 HTLBD12 506739 1393  2-331 4080 Ala-2 to Pro-8, H0253: 2 Pro-57 to Trp-67, Cys-69 to Gly-74. HTLBE55 967408 1394  2-232 4081 Glu-6 to Thr-15, H0253: 1, H0038: 1 Ser-21 to His-34, and H0616: 1. Arg-53 to Ala-64. HTLBE82 780116 1395 209-481 4082 Ser-1 to Gly-8, L0366: 3, H0618: 2, 9q31-q34 109400, Thr-15 to Thr-23, H0253: 1 and L0754: 1. 125270, Pro-45 to Pro-53. 125270, 128100, 132800, 132800, 137350, 186855, 191100, 215700, 223360, 223900, 253800, 253800, 268900, 278700, 601850, 602088 HTLBF14 971661 1396  3-590 4083 Glu-21 to Gln-27, H0616: 2, H0618: 1 Ser-30 to Lys-37. and H0253: 1. HTLBG83 527942 1397  96-200 4084 H0253: 2 HTLCA95 911655 1398  38-1096 4085 Ar061: 373, AR089: 188 H0253: 3, H0618: 2, H0038: 2, H0616: 1 and L0758: 1. HTLCG77 772644 1399  2-112 4086 Gly-1 to Ile-6, L0758: 5, H0616: 3, Gly-12 to Ile-27. H0038: 2, L0794: 2 and H0253: 1. HTLCX76 767667 1400  2-277 4087 Leu-58 to Arg-68. H0253: 2 HTLCY27 682208 1401  2-301 4088 Arg-9 to Cys-18, H0253: 1, L0794: 1, Arg-34 to Gly-40, L0766: 1, L0803: 1, Glu-47 to Asp-54. H0670: 1 and L0747: 1. HTLCY54 908832 1402 134-934 4089 Arg-1 to Arg-6, AR061: 5, AR089: 5 Ala-49 to Tyr-58, H0253: 4, H0618: 3, Pro-67 to Lys-80, L0758: 3, L0779: 2 and Ser-92 to Trp-108. L0794: 1. HTLCZ48 572959 1403  1-162 4090 His-1 to Gly-6. H0253: 2 HTLCZ96 815897 1404  17-286 4091 L0758: 4, L0794: 2, L0617: 1, H0253: 1, H0038: 1, L0789: 1 and L0779: 1. HTLDA58 828115 1405  2-271 4092 Ser-6 to Ser-11. H0253: 2 HTLDE53 780842 1406  72-497 4093 Asn-1 to Glu-6, L0758: 11, H0253: 3, Gly-17 to His-28, H0550: 1 and H0616: 1. Glu-33 to Ser-39, Pro-41 to Lys-51, Pro-56 to Glu-69, Ser-83 to Lys-90, Thr-97 to Ser-103, Arg-121 to Asp-131. HTLDE64 908613 1407  83-427 4094 Glu-15 to Leu-20, AR089: 25, AR061: 11 Leu-24 to Ser-47. H0253: 2 and H0618: 1. HTLDE95 616724 1408  86-298 4095 H0253: 2 HTLDF33 909254 1409  3-599 4096 Pro-7 to Gly-13. AR061: 7, AR089: 3 L0758: 6, L0789: 2, L0779: 2, H0253: 1, L0809: 1, L0666: 1 and H0648: 1. HTLDG55 911645 1410  1-192 4097 Gly-1 to Arg-10. H0253: 2 HTLDH65 839795 1411  3-431 4098 H0553: 3 and H0253: 1. HTLDI90 835850 1412 248-472 4099 H0618: 1 and H0253: 1. HTLDO94 915223 1413  90-458 4100 Met-12 to Asp-18, H0253: 2, H0188: 1 Tyr-20 to Gly-31, and H0038: 1. Lys-38 to Trp-47. HTLDP77 920546 1414  -573 4101 Gly-1 to Gly-9, H0253: 3 and H0618: Gln-15 to Arg-20, 2. Cys-53 to Arg-59, Arg-84 to Glu-89, Pro-105 to Glu-113. HTLDQ25 870057 1415  1-834 4102 Ser-3 to Ser-16. H0618: 11, H0253: 10, H0616: 6, L0758: 5, H0038: 4, L0768: 2 and H0090: 1, HTLDS55 891322 1416   -1171 4103 Ala-1 to Gln-13, AR061: 7, AR089: 2, Pro-19 to Leu-27, AR054: 2, AR051: 2, Asp-34 to Pro-40, AR050: 2 Ser-45 to Ser-52, H0618: 5, L0758: 4, Lys-105 to Pro-112, H0038: 3, H0253: 2, Pro-146 to Trp-158, H0553: 1, H0616: 1, Arg-181 to Arg-189, L0789: 1, L0663: 1 and Arg-241 to Arg-248, L0779: 1. Asp-285 to Asn-291, Gln-328 to Ile-333, Gln-369 to Thr-375, Arg-380 to Phe-390. HTLDT05 909752 1417  2-328 4104 Gly-3 to Ser-8. AR089: 11, AR061: 7 H0253: 2, L0439: 1 and L0599: 1. HTLDT81 952265 1418  1-465 4105 Pro-3 to Pro-8, H0253: 2 and H0618: Glu-22 to Gln-29. 1. HTLDU05 911649 1419  2-469 4106 Pro-89 to Ala-97. AR061: 8, AR089: 7 9q31 109400, H0253: 3, H0618: 1 132800, and L0758: 1, 132800, 186855, 223900, 253800, 253800, 278700, 602088 HTLDV31 867748 1420  61-309 4107 Gln-16 to Gly-35, H0253: 1 and S0152: 1, Gly-59 to Ser-74. HTLDX88 791684 1421 149-636 4108 Pro-5 to Gly-10, H0618: 2 and H0253: Gly-24 to Ala-33, 1. Pro-88 to Pro-95, Pro-106 to His-114. HTLDY85 573746 1422  3-425 4109 Lys-50 to Ala-55, H0038: 2 and H0253: Thr-99 to Glu-104, 1. Arg-116 to Arg-122, Lys-129 to Thr-136. HTLDZ14 573401 1423 174-347 4110 H0253: 2 HTLEB14 573464 1424  1-414 4111 Gly-63 to Arg-71. H0618: 4 and H0253: 3. HTLED72 906989 1425 102-287 4112 Leu-1 to Pro-7. H0253: 2 HTLEF94 870258 1426  33-239 4113 H0253: 2 HTLEG65 870154 1427  177-1181 4114 AR051: 12, AR054: 10, AR050: 8 H0616: 6, H0618: 2, H0253: 2 and H0038: 2. HTLEG91 870257 1428  1-111 4115 H0253: 2 HTLEH30 934287 1429  1-528 4116 Gly-1 to His-8, H0253: 2 Glu-26 to Gly-33. HTLEI47 573460 1430 124-417 4117 Flu-58 to Thr-63. H0253: 3 HTLEJ11 973302 1431  2-802 4118 Tyr-52 to Gln-60, AR061: 3, AR089: 1 15q13-qter Phe-86 to Ala-94, H0618: 3 and H0253: Lys-111 to Arg-118, 1. His-193 to Tyr-198. HTLEJ93 960314 1432  2-307 4119 His-22 to Lys-36, H0253: 5 and H0618: Asp-51 to Lys-59, 3. Gln-68 to Leu-83. HTLEK64 506747 1433  2-331 4120 Ala-1 to Cys-13, H0253: 2 Arg-32 to Ala-37. HTLEL01 917022 1434  2-202 4121 Pro-3 to Gly-9. H0253: 1 and H0616: 1. HTLEL03 575080 1435  2-106 4122 H0253: 2 3p21.3 116806, 120120, 120120, 120120, 120436, 120436, 120436, 138320, 168468, 182280, 600163 HTLEL07 953712 1436  55-555 4123 Ala-29 to Asn-37, H0253: 1 and H0617: Lys-64 to Thr-77, 1. Ile-97 to Arg-126. HTLEL31 669950 1437  3-143 4124 Pro-6 to Glu-13, H0253: 2 7q22 126650, Arg-18 to Pro-30. 126650, 154276, 173360, 173360, 602136, 602136, 602136, 602447 HTLEM46 719160 1438  1-456 4125 H0253: 2, L0777: 2 and L0759: 1. HTLEO50 506649 1439  2-265 4126 Ser-2 to Pro-10. H0253: 1 and H0038: 1. HTLEP16 574942 1440  3-443 4127 H0253: 2, L0794: 2 and S0042: 1. HTLEQ07 953706 1441  3-605 4128 His-7 to Ile-32, H0618: 2 and H0253: Glu-82 to Glu-87, 1. Lys-103 to Gly-108. HTLES43 573403 1442  49-216 4129 H0253: 2 HTLES54 574884 1443  1-282 4130 Pro-10 to Gln-19, H0038: 2 and H0253: Pro-46 to Ile-59, 1. Thr-64 to Leu-70. HTLET56 911654 1444  95-826 4131 Ser-54 to Lys-61, AR061: 6, AR089: 5 Pro-118 to Lys-128, H0253: 18, H0618: 7, Thr-208 to Ser-213, L0794: 3, H0038: 1, Ser-218 to Ala-227, H0616: 1, L0788: 1 and Pro-230 to Ser-236, L0758: 1. Pro-238 to Ser-244. HTLET78 836820 1445  2-826 4132 Leu-11 to Lys-18, AR061: 4, AR089: 2 Phe-107 to Gly-114, H0618: 10, H0253: 5, Glu-121 to Asn-128, L0758: 5, L0664: 1, Met-146 to Pro-153. L0756: 1, L0779: 1 and L0698: 1. HTLET93 573454 1446  1-111 4133 H0253: 2 HTLEV33 527956 1447  1-273 4134 Ala-8 to Gly-17, L0794: 5, H0253: 3, Pro-25 to His-34. H0618: 2, H0616: 2, L0758: 2 and L0787: 1. HTLEV95 883332 1448  52-414 4135 His-1 to Thr-6, H0616: 14, H0618: 8, His-14 to Cys-58, L0779: 4, H0253: 3, Cys-70 to Ala-77, H0038: 3, L0790: 1 and Pro-85 to Cys-109, L0758: 1. Pro-116 to Gly-121. HTLEW12 870255 1449  2-346 4136 H0253: 2, H0617: 2 and H0618: 1. HTLEW21 573458 1450  3-197 4137 H0253: 2 HTLEY11 967309 1451  2-130 4138 Arg-1 to Gly-21, H0253: 2 Gln-38 to Asp-43. HTLEY91 775310 1452  5-226 4139 Pro-38 to Trp-43, H0253: 2 Pro-47 to Lys-54, Gly-62 to Arg-72. HTLEZ14 791662 1453  2-334 4140 Asn-18 to Pro-44, H0618: 4 and H0253: Val-64 to Phe-70. 3. HTLEZ15 934288 1454  3-251 4141 Pro-5 to His-12, H0618: 2 and H0253: Glu-30 to Thr-36. 2. HTLEZ32 870261 1455  3-209 4142 H0253: 2 HTLFA74 934172 1456 279-707 4143 Ser-20 to Glu-26, H0253: 2 and H0618: Gly-31 to Ala-46, 1. Thr-62 to His-67, Arg-72 to Pro-81. HTLFC20 917128 1457  409-1041 4144 Ala-4 to Trp-10, H0618:3 and H0253: Glu-27 to Gln-32, 3. Gly-115 to Gly-122. HTLFE01 917033 1458  98-313 4145 Asn-7 to Val-12, H0253: 4 and H0038: Leu-15 to Ser-23. 1. HTLFE05 954984 1459  3-812 4146 His-1 to Cys-6, H0253: 5, H0618: 4, 7q22 126650, Glu-24 to Gly-29, H0038:1 and H0616: 1. 126650, Gln-53 to Asp-59, 154276, Gly-80 to Pro-86, 173360, Glu-142 to Ser-148, 173360, Ser-154 to Val-160, 602136, Pro-163 to Gln-180, 602136, Val-195 to Pro-200, 602136, Lys-205 to Ser-213, 602447 Ala-222 to Glu-228, Asp-239 to Gly-270. HTLFE20 934278 1460  80-475 4147 Gly-11 to Val-29, H0253: 8 and H0618: Gly-31 to Glu-38, 7. Ala-40 to Arg-48, Gly-55 to Val-65, Leu-70 to Thr-76. HTLFI28 775392 1461  2-430 4148 Pro-24 to Arg-31, H0253: 3 and H0038: Ile-66 to Leu-72, 2. Asp-90 to Glu-98. HTLFI39 953730 1462  2-622 4149 Ala-15 to Asp-23, AR089: 19. AR061: 13 7q22 126650, Thr-44 to Tyr-62. H0618: 8 and H0253: 126650, 4. 154276, 173360, 173360, 602136, 602136, 602136, 602447 HTLFI83 781303 1463  19-516 4150 Asp-13 to Leu-26, H0253: 1 and H0038: Val-38 to Val-76. 1. HTLFJ39 573462 1464  2-343 4151 Gln-7 to Phe-13, H0253: 2 Leu-14 to Val-37, Pro-50 to Leu-65. HTLGD25 870136 1465  28-600 4152 Gly-3 to Gly-9, AR061: 3, AR089: 1 Leu-51 to Gln-58, H0618: 4, H0253: 4, Leu-67 to Ser-74, H0616: 2, L0758: 2 and His-100 to Pro-106, H0038: 1 Arg-132 to Arg-138. HTLGD69 835493 1466 287-652 4153 His-27 to Ser-39, L0758: 2, H0618: 1, His-47 to Pro-55. H0253: 1, H0616: 1 and L0779: 1. HTLGG36 789656 1467  2-574 4154 Thr-13 to Ser-21, H0618: 4, L0779: 1 Arg-26 to His-44, and L0758: 1. Ala-85 to Cys-91, Thr-104 to Thr-121, Gly-156 to Arg-163. HTLGK55 868309 1468  1-483 4155 H0618: 2, H0617: 1 and L0743: 1. HTLGM02 964878 1469  62-766 4156 Lys-1 and Gly-12, H0618: 2 Glu-32 to Phe-41, Arg-69 to Leu-81, Pro-188 to Ile-195. HTLGM07 952254 1470  3-761 4157 Arg-1 to Glu-6, AR089: 21, AR061: 16 Ile-15 to Phe-23, H0618: 32, H0253: 13, Gly-59 to Phe-72, H0616: 6, L0758: 3, Pro-95 to Trp-112, H0038: 2, L0794: 2, Phe-117 to Pro-129. H0009: 1, H0688: 1, L0769: 1, L0372: 1, L0646: 1, L0363: 1, L0766: 1, L0790: 1, L0665: 1, H0670: 1 and L0779: 1. HTLGT62 918606 1471  2-547 4158 Asn-4 to Thr-10, H0618: 9, H0253: 1 Pro-46 to Asp-51. and L0758: 1. HTLGW17 958208 1472  1-768 4159 Arg-39 to Asn-44, H0618: 3 and H0253: Arg-55 to Gly-62, 3. Arg-98 to Ile-103. HTLGX90 870528 1473  61-906 4160 Pro-41 to Gly-57, L0748: 4, H0618: 3, Leu-76 to Gly-83, L0751: 3, L0749: 2, Pro-87 to Ser-95, L0777: 2, H0038: 1, Glu-97 to Pro-106, H0616: 1, L0772: 1 and Ile-122 to Glu-128, L0775: 1. Gln-152 to Arg-166, Thr-180 to Arg-187, Leu-191 to Pro-199, Glu-231 to Cys-241, Val-248 to Asp-255. HTLHC14 908428 1474  3-503 4161 Glu-38 to Phe-51, AR061: 7, AR089: 4 Pro-74 to Trp-91, H0618: 32, H0253: 13, Phe-96 to Ala-127, H0616: 6, L0758: 3, Glu-130 to Gly-148. H0038: 2, L0794: 2, H0009: 1, H0688: 1, L0769: 1, L0372: 1, L0646: 1, L0363: 1, L0766: 1, L0790: 1, L0665: 1, H0670: 1 and L0779: 1. HTLHE72 963471 1475  62-508 4162 H0618:3 and H0253: 1. HTLHL82 958334 1476  186-1103 4163 Gln-1 to Trp-27. H0253: 11, H0618: 8, L0779: 3, L0758: 3 and L0768: 1. HTLHO94 968685 1477 298-164 4164 Lys-36 to Glu-45. H0038: 2, L0747: 2, H0618: 1, L0665: 1, L0779: 1 and L0758: 1. HTLHP32 933335 1478  87-455 4165 Phe-6 to Ala-12, AR089: 35, AR061: 7 Arg-24 to Arg-35, H0618: 2 Leu-66 to Phe-84. HTLHP52 926980 1479  11-181 4166 Glu-37 to Gln-42. H0618: 2 HTLHP80 807156 1480 350-604 4167 H0618: 2 HTLHT15 946586 1481  1-381 4168 Tyr-31 to Arg-42, H0618: 2 Met-63 to Leu-69, Tyr-114 to His-123. HTLHT24 870254 1482  21-893 4169 Pro-1 to Ala-10, H0618: 26, H0253: 20 Val-27 to Gly-42, and L0758: 1. Asp-61 to Asp-66, Ser-81 to Ala-88. HTLHU04 926950 1483  2-943 4170 Gln-10 to Ile-18, L0758: 8, H0618: 4, Arg-41 to Ala-59, H0253: 1, H0038: 1 and His-115 to Lys-128, L0769: 1. Lys-143 to Glu-151, Thr-164 to Glu-169. HTLHV67 936139 1484  2-700 4171 Glu-2 to Thr-7, H0618: 3 15q23-q25 118485, Arg-64 to Lys-72, 151670, Glu-77 to Leu-83, 231680, Arg-93 to Ser-102, 272800, Ile-118 to Gln-123. 272800, 272800, 276700, 600374, 601780, HTLHZ08 958321 1485  1-675 4172 Ser-134 to Glu-139, H0618: 2 Thr-154 to Leu-160. HTLHZ10 963475 1486  2-241 4173 Arg-1 to Gln-13, H0618: 1 and H0253: Phe-16 to Pro-62. 1. HTLIA92 784817 1487  96-656 4174 Pro-7 to Lys-15, H0618: 2, L0764: 2, Asp-21 to Ser-28, H0253: 1, L0492: 1, Gln-53 to Ala-58, H0673: 1 and H0038: 1. Thr-115 to Asn-127. HTLID36 945891 1488  1-417 4175 Thr-10 to Thr-18, AR089: 7, AR061: 7 Pro-58 to Val-65. H0618: 1 and H0038: 1. HTLIK11 966043 1489 133-312 4176 Pro-11 to His-17, H0618: 2 Pro-27 to Asp-36, Ser-38 to His-43. HTLIP19 958351 1490  3-899 4177 Ser-25 to Thr-32, L0758: 6, H0616: 3, His-50 to Lys-56, H0038: 2 and H0618: 1. Glu-111 to Asp-116, Trp-156 to Lys-161, Leu-189 to Arg-202, Asp-258 to Thr-264. HTLIQ09 931046 1491 501-644 4178 H0618: 2 HTLIR30 870115 1492  3-659 4179 Leu-11 to Leu-17, H0618: 1 and H0253: Pro-22 to Leu-27, 1. Pro-40 to Lys-46, Arg-66 to Pro-73, Thr-91 to Ser-98, Val-102 to Lys-108, Gly-125 to Glu-130, Leu-138 to Asp-144, Arg-149 to Arg-158. HTLIU76 946300 1493  46-609 4180 Pro-13 to Ala-18, AR089: 9, AR061: 8 His-30 to Gln-37, L0758: 12, H0618: 6, Gly-48 to Ala-66, H0038: 3, H0253: 1, Ala-80 to Lys-92, H0050: 1, L0151: 1 and Glu-98 to Asp-103, L0768: 1. His-119 to Thr-126. HTLIV78 947234 1494 618-97  4181 Pro-18 to Asp-23, AR089: 9, AR061: 7 Arg-110 to Gln-122. L0758: 10, L0794: 3, H0618: 2, H0038: 2, H0253: 1, L0768: 1 and L0789: 1. HTLIY52 942161 1495   1-1368 4182 AR061: 0, AR089: 0 H0618: 64, H0253: 52, L0758: 6, L0779: 2, H0392: 1, H0038: 1, L0761: 1, L0803: 1, L0806: 1 and L0697: 1. HTLJA23 953729 1496  2-814 4183 Thr-50 to Tyr-58, H0618: 8 and H0253: 7q22 126650, Gly-155 to Gln-161, 4. 126650, Thr-164 to Gln-175. 154276, 173360, 173360, 602136, 602136, 602136, 602447 HTLJA24 934279 1497  3-572 4184 Ile-1 to Trp-9, H0618: 2 Gly-35 to Val-53, Gly-55 to Glu-62, Ala-64 to Arg-72, Gly-79 to Arg-85. HTLJC71 922923 1498   3-1355 4185 His-1 to Phe-9, AR061: 7, AR089: 5 Cys-13 to Thr-18, H0618: 12, H0253: 8, Pro-35 to Gly-48, H0038: 6, L0758: 6, Glu-61 to Pro-68, L0779: 5, H0616: 3, Lys-105 to Ala-136, T0041: 1, L0776: 1, Thr-144 to Gln-154, S0274: 1 and H0543: 1. Leu-163 to Gly-171, Thr-205 to Gln-222, Pro-251 to Gln-257. HTLJD35 967336 1499  1-192 4186 Cys-5 to Ser-15, H0618: 1 and H0253: Pro-36 to Pro-44. 1. HTLJD88 953714 1500 161-760 4187 Arg-15 to Glu-25, H0253: 5 and H0618: Lys-35 to Val-41, 2. Gln-70 to Pro-100. HTLJJ75 924755 1501  1-921 4188 Gln-1 to Thr-12. AR089: 11, AR061: 9 H0253: 7, H0618L 6, L0794: 2, L0779: 2, L0595: 2, H0687: 1, L0438: 1, L0741: 1 and L0758: 1. HTLJL23 922994 1502  2-619 4189 Leu-9 to Ser-14. H0618: 3, H0038: 3, H0616: 3 and H0253: 2. HTTAD55 835652 1503 132-245 4190 H0040: 3 HTTAE49 723331 1504  74-160 4191 H0040: 2 HTTAH87 509574 1505  2-232 4192 H0040: 2 HTTAJ35 707750 1506  3-194 4193 Leu-10 to Lys-16, L0770: 3, L0766: 3, Asn-43 to Ser-49. L0759: 3, L0790: 2, H0659: 2, H0040: 1, L0776: 1, L0663: 1, L0665: 1, L0752: 1 and L0755: 1. HTTAJ50 509657 1507  1-261 4194 H0040: 2 HTTAN57 509453 1508  -274 4195 Gly-21 to Gly-27, H0040: 2 Pro-38 to Gly-49, Ser-68 to Asp-73. HTTAS96 961057 1509  91-255 4196 Arg-7 to Cys-13, H0040: 2 Ser-16 to Arg-21, Ala-28 to Gly-33. HTTAU82 797726 1510  61-309 4197 Pro-6 to Asn-13, H0040: 2 Thr-25 to Gly-34. HTTBE25 509128 1511  1-156 H0040: 2 HTTBH34 530565 1512 177-326 4199 Pro-14 to Gly-20, H0040: 1, L0438: 1 Leu-23 to Asn-33. and H0658: 1. HTTBH41 530562 1513 106-264 4200 Ser-16 to Lys-22, H0031: 1 and H0040: Ser-29 to Gln-35. 1. HTTBH54 530563 1514 114-266 4201 H0040: 2 HTTBJ94 530564 1515  3-263 4202 Thr-3 to Arg-14. AR061: 4, AR089: 3 H0040: 2 HTTBN67 578085 1516  54-176 4203 H0040: 2 HTTCA15 869705 1517  2-262 4204 Glu-74 to Tyr-79. H0040: 2 HTTCD03 925390 1518 248-391 4205 Asn-1 to Ser-13. H0040: 2 HTTCD71 530393 1519  3-101 4206 H0040: 2 HTTCL35 529672 1520  72-185 4207 H0040: 2, L0766: 1 and L0758: 1. HTTCT34 973210 1521   3-1049 4208 Phe-86 to Tyr-94, AR061: 5, AR089: 2 Val-149 to Lys-155, H0040: 3 Trp-169 to Asn-179, Thr-189 to Glu-197. HTTDF50 526385 1522 191-298 4209 H0040: 2 HTTDF90 917155 1523  78-260 4210 H0040: 3 HTTDG36 968131 1524  26-280 4211 Gly-13 to Gly-19, H0040: 2 Pro-38 to Gly-50, Glu-67 to Gly-73. HTTDI21 869686 1525  3-188 4212 H0040: 1 and H0634: 1. HTTDJ65 973307 1526 155-364 4213 Ser-2 to Val-16, H0040: 3 Pro-50 to Trp-56. HTTDL38 573641 1527  47-136 4214 H0040: 2 HTTDL45 523452 1528  3-89 4215 H0040: 3 and L0792: 1. HTTDL89 959837 1529 183-341 4216 H0040: 2 HTTDN40 734318 1530  52-387 4217 Gln-8 to Ser-13, H0040: 2 Asp-20 to Tyr-27. HTTDN85 783444 1531  89-313 4218 H0040: 2 HTTDO19 908937 1532  1-333 4219 Thr-3 to Lys-9, AR089: 16, AR061: 9 Gly-14 to His-26, H0040: 2 His-30 to Lys-37, Lys-43 to Ser-49. HTTDO37 573685 1533 150-440 4220 Phe-25 to Phe-38. H0040: 2 and H0670: 1. HTTDR91 790336 1534 110-280 4221 Ile-3 to Lys-9. H0040: 2 and L0766: 1. HTTDR92 573666 1535 190-330 4222 Gly-8 to His-21. H0040: 2 HTTDS02 920589 1536 217-387 4223 H0040: 2 HTTDX84 921100 1537  1-480 4224 Pro-33 to Arg-43, H0253: 3, L0758: 2, Ala-48 to Tyr-57. H0618: 1, H0038: 1 and H0040: 1. HTTDZ54 692608 1538 125-298 4225 H0040: 2 HTTDZ91 523206 1539  2-313 4226 Ser-11 to Ala-19, H0618: 1 and H0040: Lys-27 to Ala-33. 1. HTTEB33 573719 1540 227-349 4227 H0040: 2 HTTEH58 747943 1541 149-286 4228 H0040: 2 HTTEL50 745985 1542 102-209 4229 H0040: 2 HTTEU68 967819 1543  2-766 4230 Lys-8 to Val-20, H0040: 2, L0439: 2, Ser-72 to Ala-77, L0438: 1 and L0747: 1. Ala-84 to Ser-92, Leu-110 to Lys-119. HTTEV62 573614 1544  85-285 4231 Ser-1 to Gln-7, H0040: 2, H0616: 1, Arg-9 to Glu-14, L0794: 1, L0779: 1 and Pro-16 to Val-24, L0758: 1. Arg-35 to Asp-40. HTTEY64 974107 1545 207-464 4232 H0040: 4 HTTEY67 917903 1546 598-804 4233 Ala-1 to Ala-7, H0040: 2, H0435: 1, Gly-53 to Lys-67. L0439: 1 and L0759: 1. HTTEZ34 771602 1547 168-329 4234 Arg-40 to Asn-45. H0040: 2 HTTFA16 870198 1548  1-408 4235 H0040: 1, S0150: 1 and L0601: 1. HTTFB60 869666 1549  2-220 4236 H0040: 2 HTTFG35 778426 1550  1-183 4237 Asp-14 to Gln-22. H0040: 5 HTTFG83 974284 1551 235-441 4238 H0040: 2, H0169: 1 and L0753: 1. HTTFH70 757358 1552 139-285 4239 H0040: 2 HTTFK90 787599 1553  36-263 4240 Arg-25 to Trp-32. H0040: 2, L0794: 2, L0659: 1, L0809: 1, L0779: 1 and L0752: 1. HTTFL89 974346 1554  99-419 4241 Gly-15 to Gly-21, H0040: 3 Pro-31 to Pro-46. HTTFM17 750942 1555  52-219 4242 H0040: 2, L0805: 1 17q and L0758: 1. HTTFM66 950051 1556  141-1079 4243 AR061: 6, AR089: 2 H0040: 2 HTTFS59 825922 1557  1-273 4244 H0040: 2, L0748: 2, 11p11.2-p11.1 133701, L0749: 2 and L0766: 1. 168500, 171650, 176930, 176930, 600623, 600811, 600958 HTTFT08 934460 1558  34-207 4245 Asn-23 to Gln-29, H0040: 3 Arg-37 to Asn-43. HTTFV93 925544 1559  47-169 4246 Asp-36 to Lys-41. H0040: 2 HTTFW03 923105 1560  53-202 4247 H0615: 1 and H0040: 1. HTTFX21 924775 1561  63-212 4248 L0748: 13, L0770: 4, L0777: 3, H0040: 2, L0794: 2, L0528: 2, L0789: 2, L0758: 2, H0685: 1, H0688: 1, L0662: 1, L0768: 1, L0766: 1, L0657: 1, L0526: 1, L0809: 1, L0439: 1 and L0740: 1. HTTFZ70 974066 1562 114-329 4249 Lys-20 to Lys-27. H0040: 2 and H0634: 1. HTTHH05 931004 1563 436-606 4250 Tyr-12 to Gly-17. H0634: 2 HTTHU43 953479 1564 207-542 4251 L0755: 3, L0766: 2, H0031: 1, H0634: 1, L0439: 1 and L0759: 1. HTTIG04 926752 1565  2-235 4252 His-54 to Ser-61. H0634: 2 HTTIH23 869636 1566  2-247 4253 Lys-47 to Asp-56. H0634:2 HTTIH80 869635 1567  32-226 4254 H0040: 1 and H0634: 1. HTTIL06 934089 1568 547-717 4255 H0040: 1, H0634: 1 and L0485: 1. HTTIN23 869634 1569 338-553 4256 Gln-15 to Thr-20. H0634: 2 HTTIU05 931015 1570 158-430 4257 Ala-17 to Gln-28, H0634: 2 Pro-73 to Thr-83. HTTIW81 922817 1571 294-446 4258 H0634: 3 HTTIZ05 930994 1572 112-354 4259 Ser-60 to Pro-69. H0634: 2 HTTJA11 839725 1573  13-240 4260 Glu-54 to Lys-60, H0040: 1, H0634: 1 Pro-65 to Gly-74 and L0803: 1. HTTJA47 869618 1574  18-356 4261 Glu-61 to Lys-66, H0040: 1 and H0634: Met-76 to Asn-83. 1. HTTJH13 869615 1575  3-182 4262 Gln-11 to Gly-17, H0634: 2 Glu-26 to Ser-36, Arg-53 to Ala-60. HTTJM01 913799 1576 137-283 4263 Pro-14 to Pro-20. H0634: 2 HTTJQ06 934130 1577  61-177 4264 H0040: 1 and H0634: 1. HTTJX68 974063 1578  1-147 Arg-29 to Arg-41. H0040: 1 and H0634: 1. HTTJY08 958170 1579 169-276 4266 H0634: 2 HTTKD44 948750 1580  2-448 4267 Lys-13 to Arg-21, H0549: 1 and H0634: Gly-26 to Thr-36. 1. HTTKF89 960928 1581  1-189 4268 H0040: 2 and H0634: 1. HTTKG34 915033 1582  56-181 4269 H0634: 2 HTTKK06 974311 1583 210-383 4270 H0634: 3 HTTKL80 974316 1584 228-362 4271 H0634: 3 HTTKN21 974310 1585 354-509 4272 H0634: 3 HTTKN30 920893 1586 166-429 4273 Asn-54 to Leu-60. H0634: 1, H0672: 1 and L0740: 1. HTTKP07 911390 1587  2-337 4274 Thr-15 to Asp-25, AR089: 1, AR061: 1 Glu-69 to Leu-89. H0634: 2 HTTKS13 926795 1588  65-484 4275 Ala-12 to Gly-22, H0634: 2 Pro-38 to Ser-45, Ala-77 to Pro-83, Ala-88 to Gly-93. HTTKV17 830008 1589  2-193 4276 Thr-1 to Gln-7, H0634: 2 Gly-13 to Gln-37. HUDAM29 529157 1590  3-224 4277 S0042: 2 HUDBZ78 739638 1591  2-163 4278 H0038: 1 and S0042: 1. HUKAA62 503626 1592 308-81  4279 Ala-4 to Val-11, H0059: 2 Gly-58 to Leu-64. HUKAB80 503445 1593 210-347 4280 H0059: 2 HUKAC72 966804 1594  1-309 4281 Glu-1 to Arg-14. H0059: 2 HUKAM82 954420 1595 122-322 4282 H0059: 3 HUKAX07 954359 1596  36-164 4283 Gly-23 to Pro-31. H0059: 2 HUKCC86 529727 1597  57-224 4284 Pro-1 to Lys-7. H0059:2 HUKDH28 531165 1598  26-334 4285 Ser-27 to Thr-35. H0059: 2 HUKDH50 531163 1599  3-164 4286 Asp-13 to Gln-19. H0059: 2 HUKEH36 531110 1600 139-327 4287 H0059: 2 HUKEH50 531108 1601 126-254 4288 Pro-19 to Pro-28. H0059: 2, L0657: 1, L0809: 1 and L0789: 1. HUKEK55 522213 1602  2-271 4289 Ile-49 to Gly-63, H0059: 2 and L0766: Ile-66 to Asp-77, 1. Gly-84 to Ser-90. HUKEO55 714187 1603 253-62  4290 H0059: 2 HUKES11 967604 1604  3-122 4291 Arg-1 to Ser-6, H0059: 2 Tyr-11 to Asp-17. HUKFL69 526819 1605 103-294 4292 H0059: 2 HUKFV41 537530 1606  3-302 4293 Thr-14 to Trp-20, H0059: 2 and L0803: Gly-25 to Pro-30, 2. Gln-42 to Trp-60. HUKFX63 946931 1607  2-112 4294 Cys-18 to Ser-24, AR061: 69, AR089: 1 Gly-29 to Gln-37. H0046: 1 and H0059: 1. HUNAD94 575299 1608  1-135 4295 Thr-1 to Asn-10, T0069: 2 Ser-18 to Lys-31. HUVBB90 503042 1609 184-342 4296 H0056: 2 HUVBB93 502903 1610 145-231 4297 H0056: 2 HUVBC12 933023 1611 122-289 4298 Thr-35 to Asn-45. H0056: 3 HUVCQ07 928053 1612  3-371 4299 Asp-14 to Ala-30, H0056: 7 Val-33 to Tyr-39, Ile-52 to Lys-58, Thr-83 to Arg-88. HUVCQ55 868795 1613 163-372 4300 Ile-1 to Asn-8. H0056: 10 and S0134: 1. HUVCS14 914768 1614  1-243 4301 Asn-1 to Ala-14, H0056: 1, H0623: 1 Arg-30 to Gly-37. and L0748: 1. HUVCU71 968663 1615  79-279 4302 Leu-40 to Leu-45, H0056: 2 Phe-55 to Leu-60. HUVCW62 535361 1616 139-309 4303 Arg-6 to Ala-26. H0056: 8 HUVDB28 535006 1617  38-220 4304 H0056: 6 and L0547: 1. HUVDB53 509119 1618 151-297 4305 Gly-1 to Ser-10. H0056: 2 HUVDC15 921088 1619  3-176 4306 H0056: 11, L0805: 2, L0789: 2, S0358: 1, L0375: 1, L0776: 1, L0743: 1, L0777: 1 and L0759: 1. HUVDD09 707061 1620  1-177 4307 Pro-27 to Trp-38, H0056: 2 Leu-48 to Arg-56. HUVDF13 961020 1621  1-225 4308 Arg-1 to Ser-6, H0056: 2 HUVDF84 526248 1622  2-214 4309 H0056: 2 HUVDF88 522823 1623  3-257 4310 Gly-1 to Arg-12. H0056: 3 HUVDI28 530558 1624  29-241 4311 Glu-13 to Phe-18, H0056: 2, H0623: 1 Gly-46 to Ala-56. and L0439: 1. HUVDI76 719332 1625 111-293 4312 H0056: 3 and H0623: 3. HUVDL30 530387 1626  3-110 4313 Lys-16 to Lys-36. H0056: 2 HUVDO25 679477 1627 233-412 4314 Ser-21 to Thr-29. H0623: 2, H0056: 1 and L0748: 1. HUVDP95 530386 1628  1-81 4315 Phe-7 to Trp-22. H0056: 2 and H0623: 2. HUVDS26 958027 1629 224-415 4316 Ala-2 to Gly-9. H0623: 2, H0056: 1 and L0758: 1. HUVDU51 868660 1630  3-263 4317 H0056: 1 and H0623: 1. HUVED35 430750 1631 318-572 4318 Lys-31 to Gln-40, H0040: 1, H0056: 1, Gln-42 to Met-49, H0623: 1, L0755: 1 and Lys-74 to Thr-82. L0592: 1. HUVED54 534783 1632  1-150 4319 H0056:2 HUVED65 527937 1633  75-164 4320 Gln-20 to Cys-26. H0056: 2 HUVEN50 530094 1634  3-110 4321 Arg-12 to Gly-17. H0056: 2, H0615: 1 and H0623: 1. HUVFA55 868779 1635 148-354 4322 H0056: 2 and H0623: 1. HUVFB48 967815 1636 170-343 4323 Leu-22 to Ser-31. H0056: 1 and H0623: 1. HUVFB69 868782 1637 175-330 4324 H0056: 1 and H0623: 1. HUVFC07 952080 1638  85-240 4325 Phe-1 to Gly-8. H0623: 2 and L0759: 1. HUVFH03 922064 1639 240-362 4326 Phe-3 to Arg-8, H0623: 2 Arg-21 to Ser-27. HUVFH32 934003 1640 160-294 4327 Ser-27 to Gly-32. H0623: 3 HUVFI03 868776 1641  3-131 4328 H0056: 1 and H0623: 1. HUVFK11 965765 1642 119-328 4329 Ser-46 to Pro-57. H0623: 2 HUVFK58 868784 1643 435-734 4330 His-7 to Thr-18, H0623: 2, L0749: 2, Gly-53 to Phe-59, H0056: 1 and L0794: 1. Pro-67 to Ser-74, Val-76 to Leu-85. HUVFL71 958059 1644  3-128 4331 Asp-1 to Arg-7. H0623: 2 HUVFQ03 922727 1645 213-374 4332 H0623: 3 HUVFR02 918233 1646  20-286 4333 Thr-3 to Ala-12, H0623: 2 and L0534: Ser-27 to Ala-32, 1. Ala-38 to Glu-44. HUVFT28 870617 1647  97-417 4334 Arg-1 to Ser-8, H0623: 3, H0616: 1 Pro-13 to Pro-18, and L0748: 1. Glu-55 to Trp-64. HUVFT50 868769 1648  3-371 4335 Asp-1 to Asn-10, H0545: 1 and H0623: Thr-29 to Trp-43, 1. Trp-62 to Ser-68. HUVFZ06 933942 1649 225-422 4336 Thr-9 to Asp-17, H0623: 2 Asp-43 to Arg-48. HUVGZ77 909169 1650  2-382 4337 Lys-1 to Cys-8, AR089: 2, AR061: 1 Glu-31 to Ser-37, H0623: 2, H0056: 1, Val-98 to Pro-105. L0803: 1, L0750: 1 and L0779: 1. HUVHB35 868751 1651 145-354 4338 H0056: 1 and H0623: 1. HUVBH59 963129 1652 200-400 4339 Pro-35 to Ser-46. H0623: 3 HUVHV93 908555 1653  51-344 4340 Pro-5 to Trp-10, AR089: 3, AR061: 1 Phe-20 to Met-26, H0040: 1, H0056: 1 Leu-85 to Trp-92. and H0623: 1. HUVHD88 868697 1654 158-39  4341 H0623: 2 HUVHG80 968507 1655  33-221 4342 Lys21 to Lys-27. H0623: 2 and H0056: 1. HUVHI07 952090 1656 313-522 4343 Leu-23 to Ser-35. H0056: 1, H0623: 1 and L0367: 1. HUVH)40 924621 1657  1-486 4344 Leu-51 to Val-56, H0623: 2 and L0731: 22q13.33 Ala-69 to Arg-74, 1. Thr-82 to Thr-91, Asp-116 to Ile-126, Ala-142 to Pro-147. HUVHU74 868649 1658 158-361 4345 Thr-47 to Arg-53. H0623: 2 HVCAZ38 969208 1659  3-206 4346 Ala-47 to Phe-55. H0666: 339, H0660: 3, L0751: 2, H0676: 1, H0560: 1 and H0520: 1. HVCBV04 925844 1660 519-632 4347 His-1 to ser-6. H0666: 5 HVCCC81 933449 1661  3-62 4348 H0666: 2 HVCCK04 925796 1662  3-560 4349 Arg-8 to Gly-19, H0666: 222, L0776: 5, Pro-22 to Cys-29, L0749: 3, S0358: 2, Asp-54 to Cys-65, L0763: 2, L0766: 2, Ser-68 to Ala-77, L0439: 2, L0596: 2, Glu-97 to Ser-103, H0650: 1, H0341: 1, Pro-171 to Leu-176. S0442: 1, H0009: 1, H0178: 1, H0012: 1, H0087: 1, S0150: 1, L0805: 1, L0655: 1, L0657: 1, L0659: 1, L0783: 1, L0809: 1, L0789: 1, L0663: 1, S0374: 1, L0602: 1, L0731: 1 and L0758: 1. HVVAC41 949141 1663  85-273 4350 H0672: 2 HVVAJ01 914354 1664  83-277 4351 Asp-34 to Glu-40. H0644: 1, H0658: 1 and H0672: 1. HVVAJ06 933675 1665  1-240 4352 H0672: 2 HVVBG19 968967 1666  1-171 4353 H0672: 2 HVVBK45 964102 1667 710-480 4354 Cys-14 to Tyr-21. L0666: 3 and H0672: 2. HVVBK72 933167 1668  2-397 4355 Glu-38 to Lys-43, AR061: 1, AR089: 1 Gly-125 to Thr-132. H0038: 1, H0672: 1 and L0758: 1. HVVBV44 917559 1669  3-104 4356 H0672: 2 HVVCO01 913996 1670  67-294 4357 Lys-12 to Trp-18, H0672: 2 Phe-35 to Thr-42. HWLHJ68 957834 1671  78-410 4358 Cys-17 to Lys-31. AR089: 3, AR061: 2 H0651: 709, L0766: 5, L0754: 5, L0756: 3, L0803: 2, L0779: 2, L0759: 2, S0354: 1, H0643: 1, H0013: 1, H0194: 1, H0545: 1, H0373: 1, H0252: 1, H0615: 1, H0316: 1, H0040: 1, H0641: 1, H0647: 1, S0422: 1, L0598: 1, L0369: 1, L0520: 1, L0762: 1, L0649: 1, L0804: 1, L0527: 1, L0656: 1, H0144: 1, H0702: 1, H0547: 1, H0555: 1, H0436: 1, S0028: 1, L0746: 1, L0750: 1, L0777: 1, L0780: 1, L0752: 1 and L0686: 1. HVVDT04 925793 1672 137-3  4359 L0766: 1 and H0672: 1. HVVBY08 957658 1673  2-406 4360 AR089: 14, AR061: 6 H0672: 1 HVVBM06 933528 1674 288-443 4361 Pro-33 to Gly-38, L0731: 2, L0635: 1, Leu-45 to Thr-51. L0663: 1, H0672: 1 and L0777: 1. HUVHL82 912011 1675 215-580 4362 Glu-28 to Arg-36, L0470: 1 and H0623: Pro-41 to Thr-50. 1. HUVHI06 952479 1676 1856-2053 4363 L0471: 1 and H0623: 1. HUVGP05 930892 1677  2-397 4364 Ala-18 to Arg-25. L0766: 3, H0623: 1, L0740: 1, L0745: 1 and L0779: 1. HUVFP71 950681 1678 443-204 4365 H0623: 1 and L0439: 1. HUVFI01 945834 1679  61-1212 4366 AR089: 2, AR061: 2 6p21.1-p12 179605, H0623: 1 179605, 179605, 179605, 179605, 180297, 230450, 248611, 263200, 600364, 601498, 601690 HUVFE03 922889 1680 112-258 4367 H0623: 1 and L0777: 1 HUVDO018 868783 1681  13-177 4368 Gln-26 to Gln-33, H0056: 1 Arg-38 to Thr-45. HUVDO11 967813 1682  2-277 4369 Ile-1 to Leu-10, H0056: 1 Gly-54 to Cys-77. HUVDO07 954224 1683 200-313 4370 H0056: 1 HUVDM27 521938 1684  1-144 4371 Gly-12 to Ser-17. H0056: 1 HUVDH61 526590 1685  80-343 4372 Ser-10 to Arg-15. H0056: 1 HUVCU26 974232 1686 420-701 4373 Leu-12 to Trp-20, H0056: 1 Ile-29 to Val-34, Ser-52 to Arg-60. HUVCM76 522660 1687  1-147 4374 Arg-17 to Ser-38. H0056: 1 HUVBC21 671479 1688  2-199 4375 Lys-1 to Arg-7, L0745: 3, L0752: 3, Phe-48 to Phe-54. H0056: 1, L0761: 1, L0803: 1, L0749: 1 and L0759: 1. HUVAA46 667943 1689 521-384 4376 H0055: 1 HUNAK12 839574 1690 120-278 4377 T0069: 1 and L0779: 1. HUNAG41 711543 1691 185-352 4378 Ser-33 to Ser-38. L0439: 4 and T0069: 1. HUNAF22 800452 1692  3-221 4379 Ser-12 to Ile-19, AR050: 45, AR051: Thr-38 to Pro-46. 39, AR054: 35 T0069: 1 HUNAF20 961527 1693 171-326 4380 Glu-26 to His-35, T0069: 1, L0764: 1, Pro-44 to Asn-49. L0771: 1, L0783: 1 and L0756: 1. HUNAE95 796691 1694  2-205 4381 L0754: 4, T0069: 1 and L0599: 1. HUNAE76 524239 1695  50-214 4382 Ala-8 to Ser-14, T0069: 1 Lys-21 to Pro-29. HUNAE02 921132 1696  2-388 4383 Thr-26 to Pro-36, T0069: 1 and L0764: 1. Ile-52 to Ser-60. HUNAD10 968590 1697 294-491 4384 T0069: 1 and L0766: 1. HUNAC68 753817 1698  65-199 4385 Asn-1 to Asn-6. T0069: 1 and L0754: 1. HUNAB76 968754 1699  2-190 4386 L0748: 2 and T0069: 1. HUNAB42 714264 1700  3-170 4387 Lys-1 to Asn-9. T0069: 1 and L0747: 1. HUKFS69 754186 1701  53-151 4388 H0059: 1 and L0756: 1. HUKFL89 574525 1702  1-174 4389 Leu-32 to Tyr-38. H0059: 1 and L0752: 1. HUKFL71 760581 1703  2-241 4390 Gly-19 to Ser-24. H0059: 1 HUKFL52 574523 1704  67-213 4391 H0059: 1 HUKFK53 577349 1705 263-433 4392 AR054: 9, AR050: 2, AR051: 1 H0059: 1 HUKFE56 574381 1706  83-226 4393 H0059: 1 and L0747: 1. HUKFD95 796014 1707  47-364 4394 Arg-26 to Arg-31. L0766: 2 and H0059: 1. HUKEY01 921504 1708  29-178 4395 Pro-7 to Gly-18. H0059: 1 and L0779: 1. HUKER62 772501 1709 532-119 4396 H0059: 1 and L0439: 1. HUKEP18 957456 1710 852-265 4397 AR061: 14, AR054: 11, AR050: 9, AR089: 4 L0758: 2, H0059: 1, L0789: 1, L0665: 1, L0749: 1 and L0779: 1. HUKDY02 920815 1711 234-482 4398 H0059: 1, L0439: 1 and L0747: 1. HUKDU47 719465 1712  33-185 4399 Met-23 to Gly-35, L0455: 1, H0059: 1 Glu-40 to Ser-50. and L0753: 1. HUKDG10 968333 1713  3-329 4400 L0465: 2 and H0059: 1. HUKCP30 690933 1714  1-105 4401 Lys-27 to His-35. H0059: 1, L0657: 1 and L0748: 1. HUKCO11 967742 1715  76-450 4402 Arg-1 to Asp-7, L0766: 2, H0059: 1, Glu-26 to Ser-31, L0764: 1 and L0774: 1. Glu-51 to Val-56, Asp-59 to Val-69, Glu-85 to Asn-94. HUKCL85 529718 1716  77-229 4403 Phe-8 to Glu-15, H0059: 1 Val-20 to Thr-25, Cys-40 to Glu-49. HUKCC25 529723 1717  84-260 4404 H0059: 1 HUKCC15 518537 1718  2-106 4405 Pro-18 to Cys-25. H0059: 1 HUKAT59 628540 1719 399-136 4406 Arg-16 to Cys-22, H0059: 1 Pro-83 to Thr-88. HUKAQ76 502711 1720 351-178 4407 H0059: 1 and L0748: 1. HUKAO47 502911 1721 379-170 4408 L0748: 2 and H0059: 1. HUKAM19 672076 1722 150-329 4409 Ala-47 to Thr-53. H0059: 1 HUKAM18 502912 1723 314-117 4410 Asp-34 to Arg-41, H0059: 1, Glu-44 to Lys-50. L0794: 1, L0789: 1, L0747: 1, L0750: 1 and L0362: 1. HUKAL44 716927 1724 139Δ402 4411 Arg-1 to Gln-7, H0059: 1, L0775: 1, Gln-11 to Ser-17, L0664: 1 and L0592: 1. Ser-41 to His-46. HUKAJ91 790487 1725 159-1  4412 L0750: 2 and H0059: 1. HUKAJ83 524257 1726 317-102 4413 Lys-1 to Gln-8. H0059: 1 HUKAD77 772734 1727  2-421 4414 Ser-30 to Val-38, H0059: 1 and L0755: Gln-44 to Ser-53, 1. Pro-56 to Gly-63. HUKAB63 625273 1728  1-207 4415 Trp-10 to Gly-16. H0059: 1 HUKAB25 677470 1729 274-2  4416 H0059: 1, L0520: 1, L0753: 1 and L0731: 1. HUKAA54 503630 1730 369-67  4417 H0059: 1 HUKAA39 503627 1731 286-2  4418 L0439: 2 and H0059: 1. 503628 2659 156-434 5346 HUDBZ01 869026 1732 213-533 4419 Arg-7 to Arg-13, AR050: 75, AR054: Asn-31 to Ser-37. 59, AR051: 51 S0042: 1 915945 2660 191-3  5347 HUDBK39 886368 1733  77-487 4420 Gly-43 to Leu-48, AR054: 2, AR051: 0, Ser-57 to Lys-67. AR050: 0 S0042: 1 HUDBE95 795796 1734 147-248 4421 S0042: 1 HUDBE64 746508 1735  56-286 4422 S0042: 1 HUDBE48 869034 1736  39-368 4423 Gly-17 to Ala-30, Gly-42 to Thr-56. HUDBE28 686520 1737  3-374 4424 Glu-1 to Leu-6, S0042; 1 Cys-10 to Asn-28, Lys-41 to Tyr-50, Gln-53 to Ser-60, Pro-67 to His-78. HUDBE02 917361 1738  3-137 4425 Phe-2 to Arg-7, S0042: 1 Asn-23 to Asn-32, Gln-39 to Asn-45. HUDAK54 899753 1739  18-710 4426 Thr-14 to Phe-26, AR051: 32, AR050: Gln-46 to Arg-52, 31, AR054: 25 Leu-74 to Tyr-84. S0042: 1 Glu-125 to Glu-132, Tyr-180 to Ser-186, Leu-216 to Pro-222, Val-226 to His-231. HUDAK19 671974 1740 109-234 4427 Glu-27 to Glu-33. L0783: 1, L0439: 1 L0731: 1 and S0042: 1. HTTKG12 969547 1741  1-171 4428 Thr-1 to Ser-10. H0634: 1 and L0593: 1. HTTKC85 956206 1742 380-240 4429 H0634: 1, L0662: 1 and L0766: 1. HTTVJ79 869602 1743  61-213 4430 H0634: 1 and L0766: 1. HTTJN26 869612 1744 132-497 4431 Glu-53 to Gln-62, L0770: 3, L0777: 3, Gly-80 to Val-86. L0518: 2, L0779: 2, L0758: 2, L0608: 2, H0634: 1, L0764: 1, L0803: 1, L0749: 1 and L0752: 1. HTTJK06 934094 1745  2-577 4432 Gln-1 to Trp-16, H0634: 1 and L0565: Asp-18 to Gly-25, 1. Leu-38 to Pro-43, Trp-146 to Gly-153. HTTIX05 931024 1746 395-532 4433 H0634: 1, L0803: 1, L0749: 1 and L0779: 1. HTTIR33 974323 1747 136-345 4434 Lys-11 to Glu-18. H0634: 1 HTTIR04 926772 1748  86-235 4435 H0634: 1, L0766: 1 and L0588: 1. HTTIN11 965920 1749 452-625 4436 L0745: 2 and H0634: 1. HTTIE08 958169 1750 195-329 4437 Ala-10 to Thr-16. H0634: 1 and L0731: 1. HTTIB12 969568 1751  1-216 4438 Pro-25 to Thr-31, H0634: 1 and L0748: Pro-59 to Gly-72. 1. HTTHJ56 944914 1752  87-218 4439 Asn-1 to Arg-11, L0157: 1 and H0634: Val-23 to Ser-28, 1. Asp-35 to Tyr-44. HTTFG12 751809 1753 128-373 4440 Leu-21 to Gly-30. H0040: 1 HTTEZ61 742004 1754 146-301 4441 Ser-24 to His-34. H0040: 1 and L0439: 1. HTTEQ59 739445 1755  57-230 4442 H0040: 1, L0766: 1 and L0748: 1. HTTEQ01 917156 1756  2-205 4443 Pro-28 to Thr-38, H0040: 1, L0803: 1, Gly-47 to Arg-52. L0439: 1 and L0777: 1. HTTEO59 900662 1757  1-153 4444 Gly-1 to Asp-8, AR061: 5, AR089: 5 Leu-15 to Cys-20, H0040: 1 Gly-24 to Ser-29. HTTEO53 728344 1758 396-545 4445 Arg-2 to Ile-8, H0040: 1, L0740: 1 Ser-34 to Cys-44. and L0747: 1. HTTEJ56 573669 1759  1-339 4446 Pro-1 to Glu-7, AR050: 2, AR051: 1, Thr-29 to Gly-35, AR054: 0 Glu-63 to Ile-68, L0439: 3 and H0040: Glu-89 to Asn-95, 1. Glu-98 to Leu-105. HTTEB05 932294 1760  1-387 4447 Arg-10 to Asp-15. L0483: 1 and H0040: 1. HTTDO59 744438 1761 511-747 4448 Arg-1 to Trp-9, L0754: 2 and H0040: 1q21 104770, Pro-13 to Gly-19, 1. 107670, Gly-24 to Pro-32. 110700, 135940, 145001, 146790, 152445, 152445, 159001, 174000, 179755, 182860, 182860, 182860, 191315, 230800, 230800, 266200, 600897, 601105, 601412, 601652, 602491 HTTDM42 460948 1762 177-401 4449 AR061: 5, AR089: 5 L0748: 2 and H0040: 1. HTTDL81 694222 1763  2-241 4450 Ala-4 to Pro-22. H0040: 1 and L0748: 1. HTTDL75 766551 1764  41-178 4451 Gly-10 to Cys-16, H0040: 1, L0742: 1 Arg-25 to Trp-31, and L0592: 1. Pro-39 to Pro-46. HTTDA85 784537 1765  3-392 4452 Arg-83 to Arg-88. H0040: 1 and L0748: 1. HTTCQ95 796674 1766  2-241 4453 Cys-19 to Pro-29. H0040: 1 and L0755: 1. HTTCJ39 709581 1767  63-266 4454 Ala-50 to Asp-55. L0745: 2 and H0040: 1. HTTCD06 960599 1768 162-413 4455 Lys-15 to Asn-23, L0754: 2 and H0040: Asp-75 to Val-82. 1. HTTCB87 524841 1769  3-236 4456 Pro-7 to Ala-26. H0040: 1 and L0748: 1. HTTBR42 714220 1770  3-272 4457 H0040: 1 and L0592: 1. HTTBP62 932997 1771  1-615 4458 Arg-12 to Gly-20, L0764: 2 and H0040: His-102 to Ser-108, 1. Ala-132 to Gln-137. HTTBO82 780164 1772 367-170 4459 Asn-24 to Asp-32. H0040: 1 and L0748: 1. HTTBM03 925409 1773  11-202 4460 Arg-18 to Trp-29. H0040: 1 and L0753: 1. HTTBI80 781590 1774  3-203 4461 Asp-1 to Gln-14, H0040: 1 and L0766: Phe-18 to Gly-33. 1. HTTBH95 530559 1775 125-256 4462 Tyr-1 to Tyr-12. H0040: 1 HTTBH75 767520 1776 175-435 4463 H0040: 1 and L0439: 1. HTTBH36 530567 1777 186-311 4464 H0040: 1 HTTAQ60 742377 1778 367-627 4465 Asn-1 to Cys-12, L0748: 3 and H0040: Asp-20 to Trp-37. 1. HTTAP45 717736 1779  65-262 4466 H0040: 1 869717 2661 151-342 5348 HTTAP21 671488 1780 632-787 4467 L0747: 2 and H0040: 1. HTTAP09 826343 1781 252-440 4468 H0040: 1 and L0591: 1. HTTAN34 509454 1782 111-230 4469 Ser-4 to Lys-12. L0595: 2, H0040: 1 and L0794: 1. HTTAJ93 791413 1783 220-420 4470 L0748: 2 and H0040: 1. HTTAH03 965134 1784  73-294 4471 Ile-15 to Phe-21, L0769: 2 and H0040: Pro-31 to Cys-39, 1. Pro-41 to Pro-49, Leu-69 to Pro-74. HTTAC77 772735 1785 435-632 4472 L0752: 2, H0040: 1 and L0756: 1. HTTAA94 793001 1786  2-271 4473 Asn-14 to Leu-20, L0749: 2, H0040: 1, Gln-30 to Pro-46. L0748: 1 and L0591: 1. HTTAA39 710355 1787 298-137 4474 H0040: 1 and L0731: 1. HTLIP06 934207 1788  20-241 4475 H0618: 1, L0751: 1 and L0758: 1. HTLID06 974047 1789 318-491 4476 Gln-10 to Ser-16. H0618: 1 HTLHV59 965808 1790  41-277 4477 Pro-8 to Ala-15, H0618: 1 and L0731: Arg-23 to Glu-35, 1. Pro-41 to Val-49. HTLHU81 870150 1791  1-345 4478 L0591: 2 and H0618: 1. HTLHU63 870147 1792 219-527 4479 Glu-33 to Arg-40. L0439: 3 and H0618: 1. HTLHS69 870152 1793 144-593 4480 Lys-34 to Pro-40, H0618: 1 and L0770: Glu-51 to Gly-56, 1. Glu-117 to Gly-124. HTLHS05 933720 1794 724-113 4481 Pro-42 to Ser-47, H0618: 1 and L0771: Ala-51 to Arg-68, 1. Leu-109 to Gly-117. HTLHK57 894863 1795  736-1140 4482 Phe-10 to Pro-19, AR054: 35, AR051: Gly-107 to Arg-112, 24, AR050: 10, AR061: Thr-128 to Lys-135. 8, AR089: 3 H0618: 1, L0766: 1 and L0749: 1. 946914 2662 1342-1788 5349 Ser-49 to Lys-58, Glu-75 to Pro-91. HTLHJ51 865399 1796 165-878 4483 Gln-3 to Arg-10, H0618: 1, L0749: 1 Leu-74 to Arg-80, and L0759: 1. Pro-87 to Cys-92, Ser-144 to Pro-158. HTLHB93 945862 1797  1-375 4484 Glu-1 to Glu-6. AR061: 1, AR089: 1 H0618: 1 and L0758: 1. HTLHA63 870172 1798 243-566 4485 H0618: 1 and L0779: 1. HTLGS10 963458 1799  1-483 4486 Ser-25 to Asn-32, L0769: 2 and H0618: His-40 to Glu-45. 1. HTLGR32 928245 1800 657-950 4487 Arg-14 to Gly-29. L0779: 3, L0758: 3, H0618: 1 and L0600: 1. HTLGP84 782194 1801  1-393 4488 Ser-1 to Lys-12, L0439: 3, L0753: 3, Met-22 to Gly-29, H0618: 1, L0741: 1, Pro-62 to Gly-69. L0745: 1 and L0746: 1. HTLGK08 958304 1802 182-388 4489 Glu-35 to Ile-51. H0618: 1 and L0758: 1. HTLGC43 870228 1803  3-350 4490 Glu-1 to His-15, L0794: 2, H0618: 1 Gly-21 to Cys-26, and L0768: 1. Thr-34 to Pro-42, Pro-49 to Glu-57. HTLEQ92 932882 1804  3-305 4491 L0439: 3 and H0253: 1. HTLEP21 671151 1805  3-416 4492 Val-25 to Ala-31. H0253: 1 and L0767: 1. HTLEN77 772363 1806  90-422 4493 Ala-1 to Ala-35. AR089: 33, AR061: 18 L0748: 2 and H0253: 1. HTLEM92 573400 1807  1-429 4494 Gly-1 to Arg-13, H0253: 1 Phe-19 to Arg-33. 792812 2663 360-599 5350 Glu-28 to Val-34, Trp-58 to Ser-64. HTLEL16 384492 1808  2-355 4495 Thr-30 to Glu-35, H0253: 1 and L0439: Asp-101 to Gly-106, 1. Ser-112 to Ser-117. HTLEG67 751842 1809 138-317 4496 Thr-6 to Ser-11. L0748: 2 and H0253: 1. HTLDZ81 778180 1810  3-296 4497 Ser-5 to Arg-17. H0253: 1 HTLDW27 961353 1811 197-601 4498 His-1 to Cys-8, H0253: 1, L0761: 1, His-35 to Phe-40. L0649: 1 and L0805: 1. HTLDO01 913669 1812  3-308 4499 Glu-63 to Ala-68, L0758: 3 and H0253: Gly-84 to Tyr-102. 1. HTLDG43 715439 1813  1-132 4500 Ala-28 to Trp-33. H0253: 1 HTLDB18 868533 1814  2-448 4501 Ser-13 to Gly-19, H0253: 1 and L0439: Leu-22 to Asn-36, 1. Asn-57 to Ser-68, Pro-82 to Trp-107. HTLCZ79 572853 1815  1-285 4502 Asp-72 to Leu-78. H0253: 1 HTLCX66 578921 1816  23-199 4503 Gly-6 to Thr-12, H0253: 1 Pro-28 to Arg-34, Asn-39 to Asn-47. HTLCO02 921045 1817 152-382 4504 Arg-50 to Trp-58. H0253: 1 and L0768: 1. HTLCG65 413333 1818  3-143 4505 Ala-14 to Asn-22. H0253: 1 HTLCG59 530039 1819  6-218 4506 H0253: 1 HTLCA03 870290 1820  50-250 4507 H0253: 1 HTLBH67 751985 1821  1-282 4508 AR061: 2, AR089: 1 L0752: 3, L0747: 2, H0294: 1, H0253: 1, H0046: 1, H0040: 1, H0063: 1, H0494: 1, S0352: 1, L0769: 1, L0766: 1, L0804: 1, L0805: 1, L0791: 1, H0521: 1, L0779: 1, L0780: 1, L0731: 1 and L0758: 1. HTLBC07 954111 1822 259-408 4509 L0758: 2 and H0253: 1. HTLBB72 766270 1823  3-590 4510 His-1 to Trp-11, H0253: 1, L0745: 1 Lys-13 to Ser-27, and L0750: 1. Glu-33 to Ser-38. HTLAI30 690936 1824 133-492 4511 L0439: 3, L0438: 2, H0253: 1 and L0769: 1. HTLAF33 870300 1825  1-228 4512 Phe-2 to Arg-12. H0253: 1 HTLAC61 683247 1826  28-165 4513 H0253: 1 6p25-ter HTLAC39 575343 1827  74-226 4514 Ala-1 to Trp-18. H0253: 1 HTLAB55 732480 1828  3-320 4515 Gln-32 to Leu-37, H0253: 1 and L0439: Gln-65 to Val-70, 1. Thr-73 to Pro-79. HTLAB29 879168 1829 133-426 4516 Gly-1 to Thr-9. H0253: 1 and L0747: 1. HTFBE02 920507 1830  1-363 4517 Asp-28 to Leu-35, AR089: 1, AR061: 0 Asp-52 to Cys-57. L0439: 2, L0021: 1, H0372: 1, L0769: 1, L0649: 1, L0748: 1, L0485: 1, L0604: 1 and L0361: 1. HTEQS95 972746 1831 311-496 4518 Ser-37 to Ser-43. H0616: 1 HTEQS90 973426 1832  86-388 4519 Pro-45 to Pro-50, H0616: 1 Arg-64 to Ser-77, Ile-88 to Ala-101. HTEQP03 870516 1833 129-596 4520 Pro-71 to Cys-82. H0616: 1 and L0794: 1. HTEQN83 908508 1834  3-293 4521 Met-12 to Met-24, AR061: 4, AR089: 1 Pro-46 to Tyr-52, L0758: 2 and H0616: Arg-92 to Lys-97. 1. HTEQB08 958291 1835 147-437 4522 Val-48 to Gly-54, L0748: 2, H0616: 1 Asp-63 to Arg-74, and L0747: 1. Gly-87 to Leu-92. HTEPY28 870559 1836 263-412 4523 Ala-1 to Met-6, L0758: 3 and H0616: Gly-9 to Ser-15. 1. HTEPV63 870549 1837 614-931 4524 Leu-47 to Thr-59, H0616: 1, L0519: 1, Pro-73 to Pro-87. L0748: 1 and L0779: 1. HTEPE35 948475 1838 839-78  4525 Tyr-1 to Lys-8, AR061: 4, AR089: 1 Phe-19 to Ser-24, L0758: 7, L0768: 2, Thr-28 to Ser-34, H0616: 1 and L0151: 1 Pro-54 to Trp-70. HTEOY82 948845 1839 159-392 4526 H0616: 1 and L0779: 1. HTEOO83 836721 1840  1-318 4527 Lys-22 to Asp-27. H0616: 1 and L0774: 1. HTEOE28 870581 1841  18-296 4528 Leu-80 to Lys-86 H0616: 1 and L0779: 1. HTENY44 870588 1842  3-191 4529 Asp-16 to Arg-23, L0758: 3, H0616: 1, Leu-40 to Asp-47. L0794: 1, L0791: 1 and L0779: 1. HTENV06 933294 1843 133-390 4530 Glu-1 to Ser-10. H0616: 1 and L0755: 1. HTENS74 773925 1844  3-329 4531 Arg-30 to Arg-37, L0755: 2 and H0616: 17p13.3 113721, Asn-40 to Glu-46, 1. 247200, Leu-56 to Arg-64, 600059, Ala-85 to Arg-102. 601545 HTENR26 870595 1845  15-146 4532 Thr-12 to Ile-17. H0616: 1 and L0768: 1. HTENQ92 790908 1846  54-494 4533 Ala-6 to Trp-19, L0731: 3, H0616: 1 Leu-34 to Gln-39, and L0750: 1. Asp-63 to Arg-76, Thr-94 to Gly-105, Asp-108 to Phe-113, Lys-122 to Phe-128, Asn-131 to Glu-136, Arg-142 to Gly-147. HTENP08 958382 1847  58-447 4534 Tyr-2 to His-7 H0616: 1 and L0794: 1. HTENL95 795314 1848 149-322 4535 Pro-43 to Ile-51. L0748: 2, H0616: 1, L0439: 1 and L0740: 1. HTENL73 974363 1849 109-426 4536 Pro-29 to Thr-34, H0616: 1 Cys-42 to Ser-47, Gln-52 to His-58, Pro-68 to Cys-80. HTENA08 958380 1850  60-206 4537 H0616: 1 and L0758: 1. HTEMY05 880592 1851  1-363 4538 Cys-18 to Lys-43, H0616: 1 and L0362: Ser-45 to Leu-52, 1. Ser-63 to Ser-68, Lys-75 to Arg-80, His-113 to Lys-121. HTEMV66 813038 1852  1-318 4539 Ser-38 to Pro-45. AR061: 5, AR089: 1 H0616: 1 and L0758: 1. HTEMU66 944419 1853 454-963 4540 Ala-1 to Gln-7, AR061: 7, AR089: 5 Lys-24 to Ser-30, Pro-44 to Asn-53, Glu-104 to Asp-112, Leu-152 to Ser-157. HTEMS01 915308 1854  21-197 4541 Glu-3 to Cys-9, L0758: 4 and H0616: Gln-32 to Asp-45. 1. HTEMO58 964769 1855  77-361 4542 H0616: 1 and L0758: 1. HTEMN80 775543 1856  51-137 4543 H0616: 1 and L0439: 1. HTEMM91 968396 1857  58-378 4544 His-15 to Arg-22. H0616: 1 and L0747: 1. HTEMI51 870613 1858 283-573 4545 Arg-24 to Pro-30. H0616: 1, L0779: 1 and L0758: 1. HTEMB57 849214 1859 198-374 4546 His-44 to Phe-49, H0616: 1 and L0758: Pro-53 to Pro-58. 1. HTELY90 787549 1860  2-250 4547 H0616: 1 and L0748: 1. HTELV29 806421 1861  33-641 4548 Pro-28 to His-34, H0616: 1 and L0594: Lys-51 to Arg-59, 1. Arg-66 to Phe-82, Thr-92 to Gln-100, Ala-106 to Gln-118, Pro-123 to Leu-133, Ala-137 to Glu-147, Arg-185 to Leu-190. HTELP07 952274 1862 102-296 4549 Thr-15 to Lys-28, H0616: 1, L0764: 1, Gly-47 to Thr-54. L0779: 1 and L0758: 1. HTELM71 954892 1863  63-329 4550 Pro-24 to Asn-37, L0758: 2 and H0616: Asp-43 to Thr-49, 1. Leu-63 to Gln-72. HTELA02 918699 1864 185-451 4551 Ala-48 to Lys-57, L0794: 2, H0616: 1 Ser-75 to Phe-84. and L0758: 1. HTEKU62 754010 1865  43-657 4552 His-1 to Lys-7. H0038: 1 and L0439: 1. HTEKI62 812862 1866  68-286 4553 Pro-43 to Asn-48. L0766: 2, H0038: 1, L0637: 1, L0750: 1 and L0590: 1. HTEKH17 942526 1867  83-391 4554 AR061: 29, AR050: 21, AR054: 21, AR089: 11, AR061: 11 H0038: 1 HTEKD77 772397 1868 105-428 4555 Ala-5 to Arg-15. H0038: 1 and L0756: 1. HTEJV94 793039 1869  92-241 4556 Pro-19 to Phe-28. L0758: 2 and H0038: 1. HTEJO46 717850 1870 282-401 4557 Ser-5 to Cys-16, H0038: 1 and L0743: Glu-20 to Ile-25. 1. HTEJN12 653252 1871  1-279 4558 H0038: 1 and L0595: Xp22 300000, 1. 300066, 300077, 300310, 301220, 302350, 304050, 304110, 306100, 309530, 309585, 312040 HTEJL30 696784 1872  23-301 4559 L0748: 2 and H0038: 15q21.1-q21.2 107910, 1. 107910, 109700, 114240, 134797, 134797, 134797, 151670, 600839, 601780, 602099 HTEJC70 490772 1873 601-380 4560 H0038: 1 and L0748: 1. 870649 2664  1-330 5351 Arg-1 to Arg-6, Pro-17 to Ala-23, Gly-33 to Gln-40, Arg-45 to Arg-73. HTEJB07 953801 1874  79-264 4561 Thr-1 to Gly-7, L0779: 3, L0758: 2 and Cys-35 to Gly-51. H0038: 1 HTEIS34 887112 1875 383-135 4562 Cys-33 to Asn-38. H0038: 1 and L0366: 1. HTEIS25 870660 1876  3-299 4563 Pro-31 to Arg-37, L0758: 4 and H0038: Phe-39 to Ala-55. 1. HTEIN26 684711 1877 178-417 4564 Gly-1 to Glu-9, H0038: 1 and L0754: Ile-12 to Lys-30, 1. Cys-34 to Lys-39, Glu-55 to Gln-62, Val-66 to Lys-72. HTEIL36 708304 1878  69-395 4565 H0038: 1, L0768: 1, L0438: 1 and L0779: 1. HTEIJ58 491030 1879 379-179 4566 Asp-19 to Ser-25. H0038: 1 870667 2665  3-281 5352 Ile-1 to Phe-9, Gly-73 to Gly-82. HTEID15 395868 1880  44-151 4567 Gln-1 to Leu-6. H0038: 1 HTEIB38 839966 1881  39-296 4568 His-1 to Asp-9, H0038: 1 and L0779: Lys-37 to Glu-45. 1. HTEIB37 870671 1882  19-264 4569 Gln-11 to Cys-18. H0038: 1 HTEIB03 921926 1883  35-235 4570 Pro-2 to Thr-13. H0038: 1 HTEIA57 734983 1884  1-225 4571 Glu-1 to Ser-18. L0748: 2 and H0038: 1. HTEHX57 734976 1885 279-446 4572 Gly-14 to Val-21, H0038: 1, L0740: 1 Thr-25 to Leu-32. and L0754: 1. HTEHV11 967439 1886  59-361 4573 Gln-9 to Ala-21, H0038: 1, L0779: 1 Thr-24 to Thr-29. and L0758: 1. HTEHS17 664436 1887  15-233 4574 Lys-30 to Leu-39, L0758: 3, L0151: 2, Glu-42 to Ser-53. H0038: 1 and L0779: 1. HTEHJ11 964956 1888 147-254 4575 Gly-10 to Arg-19. L0163: 1 and H0038: 1. HTEGW02 920628 1889  64-747 4576 Lys-1 to Arg-27, L0758: 3, L0776: 2, Thr-42 to Met-57, L0779: 2 and H0038: 1. Gln-89 to Ala-95, Asp-113 to Ser-119, Thr-128 to Thr-156, Phe-179 to Ser-187. HTEGU55 931017 1890 173-388 4577 Ala-1 to Lys-10, L0439: 2 and H0038: 20q13.12 602025 Pro-29 to Ser-36, 1. Gly-46 to Ser-58, Ile-62 to Cys-67. HTEGS24 932987 1891 130-600 4578 Glu-13 to Ser-20, H0038: 1 and L0766: Pro-33 to Phe-38, Ser-41 to Lys-49. HTEGJ74 765901 1892  3-452 4579 AR089: 3, AR061: 2 L0439: 2 and H0038: 1. HTEGJ56 732630 1893 272-457 4580 Asp-26 to Trp-35. H0038: 1 and L0755: 1. HTEGI38 709420 1894  74-325 4581 H0038: 1 and L0749: 1. HTEGH60 545137 1895  3-221 4582 Gly-5 to Gly-12. H0038: 1 HTEGC30 690998 1896  2-97 4583 H0038: 1 and L0756: 1. HTEFX90 887616 1897  3-581 4584 AR050: 9, AR051: 3, AR054: 1 H0038: 1, L0750: 1 and L0755: 1. HTEFU18 666920 1898  3-353 4585 Leu-25 to Asp-35, H0038: 1, L0766: 1, Ser-41 to Tyr-47, L0789: 1 and L0749: 1. Trp-72 to Pro-77, Lys-106 to Arg-112. HTEFO46 719280 1899 133-408 4586 Pro-28 to Tyr-38, L0591: 2, H0038: 1, Thr-40 to Lys-48, L0381: 1, L0779: 1 and Val-61 to Thr-69, L0758: 1. Glu-74 to Gln-82. HTEFO28 685383 1900 150-464 4587 Thr-6 to Gln-12. H0038: 1, L0744: 1 and L0756: 1. HTEEU78 530196  2-256 4588 Ile-1 to Ala-7, H0038: 1 Arg-26 to Gly-38. HTEEU35 707717 1902  2-115 4589 H0038: 1 HTEEU27 575476 1903  99-227 4590 Glu-15 to Ser-20. H0038: 1 HTEEU18 530203 1904  2-280 4591 Ser-14 to Ser-25, H0038: 1 and L0758: 1p21 102770, Leu-42 to Glu-62, 1. 120280, Ala-75 to Thr-84. 120280, 166600, 170995, 232400, 232400, 600309, 601414, 601691, 601691, 601691, 601691, 601718, 602094 HTEEU17 530200 1905  76-303 4592 Pro-40 to Leu-50, H0038: 1 Ser-64 to Gln-74. HTEET22 675071 1906 206-373 4593 Thr-20 to His-29, H0038: 1, L0756: 1 Pro-31 to Ser-38. and L0758: 1. HTEEF25 677513 1907 123-341 4594 H0038: 1, L0794: 1 and L0758: 1, HTEEB82 780161 1908 151-288 4595 Ser-11 to Arg-19. L0748: 2 and H0038: 1. HTEDX39 530201 1909 123-260 4596 H0038: 1 HTEDX04 927850 1910 114-344 4597 H0038: 1 HTEDX03 925353 1911  1-204 4598 H0038: 1 HTEDW96 881958 1912  86-511 4599 Thr-48 to Ser-53, L0601: 2 and H0038: 2q37.2 Gly-63 to Arg-68, 1. Gly-77 to Trp-85, Gln-99 to Gly-112, Arg-131 to Arg-142. HTEDW59 530448 1913  1-213 4600 Gly-17 to Glu-29. H0038: 1 HTEDV86 785818 1914  86-322 4601 Ser-47 to Phe-57. H0038: 1 and L0749: 1. HTEDU53 727362 1915  2-253 4602 Gly-22 to Arg-28. H0038: 1 and L0756: 1. HTEDS40 934047 1916 147-509 4603 H0038: 1 HTEDS06 960645 1917 625-170 4604 H0038: 1 and L0779: 1. HTEDO75 767024 1918  60-197 4605 H0038: 1 HTEDK72 766343 1919 137-283 4606 H0038: 1 and L0740: 1. HTEDJ92 522827 1920  3-143 4607 H0038: 1 HTEDJ63 508086 1921  29-322 4608 H0038: 1 HTEDI09 522969 1922 233-409 4609 H0038: 1 HTEDI01 961028 1923  92-229 4610 H0038: 1 HTEDH90 909165 1924  3-311 4611 Phe-1 to Pro-7, AR061: 3, AR089: 1 Trp-32 to Thr-39. H0038: 1 HTEDH76 522940 1925  3-170 4612 Gly-2 to Ile-13. H0038: 1 HTEDH42 615250 1926  18-353 4613 Leu-56 to Leu-63, AR061: 6, AR089: 4 Gly-103 to Arg-108. H0038: 1 HTEDH30 522936 1927  1-249 4614 Asn-1 to Gly-17. H0038: 1 HTEDH17 522938 1928  80-385 4615 Pro-67 to Gly-75. H0038: 1 HTEDH06 869427 1929  2-361 4616 Ile-1 to Lys-9, H0038: 1 Pro-88 to Lys-100. HTEDG75 890715 1930 162-371 4617 Arg-43 to Thr-50. AR050: 42, AR054: 35, AR051: 33 H0038: 1 HTEDG26 519947 1931  1-396 4618 Asn-1 to Arg-8, H0038: 1 Leu-18 to Asp-23, Glu-84 to His-89. HTEDF96 614726 1932  1-174 4619 Leu-22 to Arg-34. H0038: 1 19q13.3 113900, 126340, 126391, 130410, 134790, 138570, 160900, 173850, 258501, 600040, 602225, 602225 HTEDF70 522977 1933  2-277 4620 Ile-1 to Gln-11. H0038: 1 HTEDF60 742368 1934  1-369 4621 Glu-1 to Gln-7, H0038: 1 Arg-16 to Asp-30, Pro-35 to Asn-43. HTEDF22 908406 1935  1-303 4622 Pro-2 to Trp-7, AR061: 8, AR089: 3 His-28 to Gly-35, L0758: 2 and H0038: Pro-37 to Gly-56, 1. Gly-68 to Lys-75. HTECE66 522997 1936  26-196 4623 Gly-36 to Gly-52. H0038: 1 HTECE62 523002 1937  1-369 4624 Ala-22 to Gly-30, H0038: 1 Asn-36 to Ala-43. HTECE61 789732 1938  85-471 4625 Ser-30 to Arg-36. H0038: 1 and L0750: 1. HTECE51 870723 1939  85-282 4626 Leu-30 to Arg-40. H0038: 1 HTECE39 650885 1940  63-401 4627 Ser-37 to Gly-49. H0038: 1 HTECE31 508104 1941  33-203 4628 H0038: 1 HTECE08 960428 1942  2-154 4629 Ile-1 to Ser-8, H0038: 1 Pro-13 to Ser-19, Gly-13 to Ile-41. HTECD94 527210 1943  1-330 4630 Val-28 to Cys-55, H0038: 1 7q11-q22 126650, Arg-71 to Cys-90, 126650, Pro-102 to Pro-107. 154276, 173360, 173360, 602136, 602136, 602136, 602447, HTECD88 527214 1944 246-356 4631 H0038: 1 HTECD70 527203 1945  2-211 4632 Ala-28 to Ser-43, H0038: 1 Ala-57 to Tyr-64. HTECD65 533795 1946 144-341 4633 H0038: 1 HTECD56 527209 1947  3-119 4634 Ala-10 to Thr-18. H0038: 1 HTECD15 523029 1948  3-251 4635 Pro-23 to Val-32, H0038: 1 Ala-54 to Ala-60, Thr-68 to Gly-73. HTECC71 508142 1949  3-173 4636 Glu-39 to Cys-57. H0038: 1 HTECC45 508124 1950  20-142 4637 Phe-1 to Gly-10, H0038: 1 Leu-32 to Cys-39. HTECC26 508144 1951  74-202 4638 Ser-21 to Ser-29, H0038: 1 Ala-31 to Thr-37. HTECC09 678659 1952  3-365 4639 Arg-1 to Pro-6. AR089: 39, AR061: 19 H0038: 1 HTECC08 960439 1953  2-151 4640 H0038: 1 HTECA44 508135 1954  56-439 4641 Ile-4 to Lys-23, H0038: 1 Arg-87 to Cys-103. HTECA39 508132 1955 105-236 4642 Gly-9 to Leu-17, H0038: 1 Arg-38 to Glu-44. HTEBP54 728811 1956 559-744 4643 L0754: 2 and H0038: 1. HTEBO43 715704 1957  3-266 4644 Gly-42 to Gln-53, H0038: 1 Leu-67 to Glu-76. HTEBM87 503275 1958  78-230 4645 Glu-16 to Lys-21, H0038: 1 Met-25 to Tyr-32. HTEBL53 578544 1959 110-367 4646 Pro-7 to Cys-13, H0038: 1 Glu-41 to Trp-46, Ser-60 to Gln-65. HTEBJ02 921321 1960 123+144 299 4647 H0038: 1 and L0748: 1. HTEBH09 870732 1961  23-346 4648 Glu-7 to Gly-14. H0038: 1 and L0758: 1. HTEAX06 960792 1962 134-394 4649 Ala-7 to Val-13, L0758: 3, L0666: 2, Pro-15 to Val-21. L0021: 1, H0038: 1 and L0665: 1. HTEAV22 679394 1963 151-462 4650 L0439: 2, L0717L 1, H0038: 1, L0769: 1, L0772: 1, L0800: 1, L0666: 1, L0758: 1 and L0601: 1. HTEAU39 503295 1964 371-144 4651 Ser-8 to Asn-19. L0439: 4 and H0038: 1. HTEAT17 667184 1965  45-311 4652 L0758: 5, H0038: 1 and L0768: 1. HTEAS02 921323 1966  79-324 4653 H0038: 1 and L0758: 1. HTEAR93 503298 1967 373-230 4654 Ser-19 to Trp-27. H0038: 1 HTEAQ55 732562 1968  3-398 4655 Asn-14 to Gln-20, L0740: 3, L0731: 3, Arg-28 to Glu-40. L0748: 2, L0757: 2 and H0038: 1. HTEAJ96 503533 1969 216-434 4656 Phe-10 to Ser-16, H0038: 1 Ser-24 to Gly-50. HTEAH75 503546 1970 145-336 4657 H0038: 1 HTEAG47 503623 1971 146-268 4658 Ala-15 to Leu-24, L0748: 2 and H0038: Pro-32 to Cys-41. 1. HTEAG08 960469 1972  17-172 4659 H0038: 1 and L0766: 1. HTEAB50 724751 1973  7-324 4660 Ser-17 to Cys-23, H0038: 1 and L0758: Pro-25 to Ala-32. 1. HTEAA04 925522 1974 106-348 4661 Arg-20 to Tyr-28, L0758: 2 and H0038: Phe-31 to Arg-38, 1. Asp-44 to Arg-51. HSWBY36 708291 1975  87-218 4662 Arg-17 to Gly-22. H0546: 1, L0598: 1 and L0759: 1. HSWBT69 867537 1976  3-380 4663 Ala-26 to Pro-31. H0546: 1 and L0757: 1. HSWBE29 412991 1977  12-152 4664 Phe-1 to Asn-9. H0546: 1 and L0756: 1. HSWAS65 953051 1978  15-404 4665 Leu-15 to Phe-35, H0546: 1 17q21 109270, Pro-52 to Ser-58. 109270, 109270, 109270, 109270, 113705, 113705, 114200, 148065, 148066, 148066, 148067, 148067, 148069, 148080, 154275, 168610, 171190, 176705, 185800, 200350, 221820, 232200, 249000, 252920, 253250, 600119, 600119, 601363, 601844 HSWAS18 666302 1979 200-418 4666 Lys-1 to Ser-8. L0744: 3, L0021: 1, H0546: 1, L0768: 1 and L0657: 1. HSWAR63 471236 1980  61-222 4667 Asn-19 to Asp-30. H0546: 1 19q13.2 107741, 113900, 122720, 122720, 126340, 126391, 160900, 164731, 173850, 207750, 248600, 258501 HSWAQ31 697856 1981 194-418 4668 H0546: 1 HPWTA06 936026 1982  71-427 4669 H0383: 1 and L0589: 1. HPWSA52 727294 1983 155-349 4670 Pro-20 to Ser-27. S0174: 1 and L0755: 1. 6p22.1-q22.3 120110, 121014, 142470, 156225, 164200, 164200, 601316, 601410, 601757 HPWDK45 839559 1984 141-533 4671 Lys-9 to Pro-14. S0044: 1 and L0748: 1. HPWDF03 924978 1985 168-452 4672 L0749: 4, L0748: 2 and S0044: 1. HPWDE86 785710 1986 166-291 4673 Cys-13 to Pro-26, L0754: 2 and S0044: 1. Pro-34 to Val-40. HPWCJ90 789170 1987  17-397 Cys-1 to Asn-16, L0731: 2, S0044: 1 and Thr-20 to Asp-44, L0749: 1. Ser-47 to Asn-54, Phe-66 to Arg-93. HPWCG85 638155 1988 461-727 4675 Ser-25 to Glu-33, S0044: 1 Ser-58 to His-68. 812707 2666 585-319 5353 Ser-25 to Glu-33, Ser-58 to His-68. HPWBF35 707514 1989  36-164 4676 Asn-32 to Thr-40. S0044: 1 and L0608: 1. HPWBE47 720563 1990 251-520 4677 Arg-1 to Ile-6, S0044: 1 and L0581: 1. Pro-9 to Met-16, Gly-32 to Arg-37. HPWAT23 676323 1991  73-258 4678 Ser-21 to Pro-29, S0044: 1 and L0752: 1. Leu-42 to Ser-52. HPWAJ85 535157 1992  73-219 4679 Gln-1 to Gly-11. S0044: 1 and L0439: 1. HPWAJ39 575271 1993  72-215 4680 S0044: 1 HPWAI05 932627 1994  2-250 4681 Pro-1 to Pro-9, L0748: 2 and S0044: 1. Ser-36 to Gly-43, Leu-48 to Gln-62. HPWAH19 468246 1995 201-1  4682 Pro-13 to Arg-23, S0044: 1 Pro-41 to Trp-53, Pro-56 to Lys-65. 867315 2667  27-275 5354 HPWAG31 693618 1996  19-165 4683 Arg-28 to Pro-42. S0044: 1 HPVAH71 829301 1997  2-178 4684 S0013: 1 and L0756: 1 HPVAH41 848632 1998 351-614 4685 Asp-9 to Phe-18, L0748: 2, S0013: 1 and Pro-44 to Trp-52. L0743: 1. HPVAC74 773298 1999  2-637 4686 His-42 to Lys-52. S0013: 1 and L0740: 1. HPVAB16 526124 2000  18-155 4687 S0013: 1 HPVAB01 961017 2001  88-261 4688 S0013: 1 and L0746: 1. HPRTJ65 753933 2002 391-549 4689 Gly-27 to Glu-33, H0212: 1, L0750: 1 Cys-46 to Lys-53. and L0777: 1. HPRTI54 728812 2003  91-351 4690 L0605: 2, H0212: 1 and L0748: 1. HPRTI16 667652 2004  81-470 4691 L0777: 4, H0212: 1, L0809: 1, L0664: 1 and L0750: 1. HPRCV66 320393 2005 296-472 4692 Ser-1 to Thr-9. H0032: 1 and L0748: 1. HPRCT83 780264 2006  37-177 4693 L0731: 2 and H0032: 1. HPRCN03 925420 2007  2-166 4694 H0032: 1, L0761: 1 and L0758: 1. HPRCM12 973740 2008  45-278 4695 Lys-11 to Ser-19, H0032: 1 Lys-72 to Gln-78. HPRCL72 766311 2009  3-248 4696 Lys-4 to Val-12, H0032: 1 and L0756: Ser-23 to Ser-39. 1. HPRCI73 764710 2010  2-298 4697 H0032: 1 HPRCG46 719340 2011 175-462 4698 Glu-41 to Ser-46. H0032: 1 and L0439: 1. HPRCD11 967762 2012  2-115 4699 Ile-1 to Arg-6, H0032: 1 and L0748: Val-27 to Gly-32. 1. HPRCC22 526623 2013  99-236 4700 Arg-6 to Leu-15. H0032: 1 HPRCA02 917289 2014 142-315 4701 Gln-14 to Tyr-19. H0032: 1 919513 2668 205-11  5355 Arg-22 to Asp-27, Gln-36 to Glu-42, Leu-46 to Glu-56. HPRBN23 467480 2015 200-454 4702 Cys-73 to Lys-82. H0032: 1 486123 2669 484-320 5356 867409 2670 106-282 5357 HPRBI87 695116 2016  93-227 4703 Met-1 to Asn-9. H0032: 1 and L0731: 19p13.3-p13.2 108725, 1. 120700, 133171, 136836, 143890, 145981, 147141, 147670, 147670, 147670, 151440, 164953, 188070, 231670, 600276, 600957, 601238, 601843, 601846, 602216, 602477 HPRBH80 781636 2017 183-344 4704 Ser-21 to Gln-27. H0032: 1 and L0748: 1. HPRAV80 781637 2018  1-384 4705 L0439: 3 and H0032: 1. HPRAN56 503140 2019 338-210 4706 Glu-18 to Val-30. L0756: 3, L0747: 2, L0749: 2, H0032: 1 and L0748: 1. 503152 2671 373-543 5358 HPRAN50 724753 2020 300-196 4707 H0032: 1 HPRAJ75 766496 2021  3-197 4708 Ser-19 to Cys-35. H0032: 1 HPRAG73 764757 2022 267-584 4709 H0032: 1 and L0749: 1. HPRAG45 484691 2023 281-84 4710 Gly-7 to Thr-27, H0032: 1 Pro-60 to Gln-66. 939849 2672  3-365 5359 Ile-1 to Ser-8, Ser-103 to Pro-108. 939850 2673  1-57 5360 Arg-9 to Tyr-14. HPRAF86 784594 2024  2-232 4711 Thr-13 to Met-23. H0032: 1 HPOAB37 789290 2025  2-406 4712 Ala-1 to Gln-7. S0004: 1 HPMSH94 796839 2026 192-368 4713 Lys-13 to Lys-18. H0111: 1 and L0766: 1. HPMSB35 707476 2027  30-206 4714 H0111: 1 and L0750: 1. HPMMK05 928283 2028 558-746 4715 Ser-14 to Arg-19, L0754: 2, H0644: 1, Glu-43 to Ser-54. L0747: 1 and L0750: 1. HPMMB08 957945 2029 105-299 4716 H0644: 1 and L0755: 1. HPMKP06 933895 2030  3-248 4717 Gln-48 to Asp-65. H0644: 1 and L0777: 1. HPMKC05 930874 2031  87-257 4718 Asn-8 to Asp-28. H0644: 1 and L0748: 1. HPMJT12 969483 2032 242-487 4719 Lys-15 to Leu-25, L0748: 4 and H0644: Met-29 to Leu-43. 1. HPMJN08 958009 2033  2-259 4720 His-4 to Arg-20. H0644: 1 and L0748: 1. HPMJK11 965636 2034 277-516 4721 Ser-42 to Ser-52. H0644: 1 and L0462: 1. HPMJK03 867615 2035 293-436 4722 H0644: 1 and L0700: 1. HPMJI11 965627 2036  61-381 4723 Gln-7 to Gly-18, H0644: 1 and L0774: Asp-21 to Met-28. 1. HPMJE06 939682 2037 169-2  4724 Tyr-39 to Arg-56. H0644: 1, L0606: 1 and L0749: 1. HPMJA11 965628 2038  1-327 4725 L0745: 4 and H0644: 1. HPMGX92 491004 2039 346-158 4726 Glu-36 to Ala-43, H0031: 1 Pro-45 to Lys-57. 881472 2674  63-350 5361 Leu-20 to Arg-26, Ala-38 to Thr-43, Trp-90 to Ala-96. HPMGR15 660374 2040 178-378 4727 Pro-18 to Glu-24. H0031: 1 and L0756: 1. HPMGO88 463906 2041 267-440 4728 H0031: 1 and L0756: 1. HPMGM39 705460 2042  865-1128 4729 Thr-1 to Ser-6, L0748: 6, H0031: 1, Glu-49 to Phe-63. L0747: 1, L0756: 1 and L0596: 1. HPMGJ16 662021 2043  85-195 4730 Lys-28 to Ser-33. H0031: 1 HPMGD63 694518 2044 177-380 4731 Gln-6 to Gly-11, H0031: 1 and L0748: Phe-21 to Thr-30, 1. Arg-50 to Thr-63. HPMFX29 690704 2045  6-161 4732 L0747: 2 and H0031: 1. HPMFL73 867670 2046 203-592 4733 H0031: 1 HPMFC02 920327 2047 112-576 4734 Pro-41 to Ala-63, L0770: 2, L0779: 2, Gly-69 to Gly-81. H0031: 1, L0766: 1, L0776: 1 and L0758L 1. HPMFB26 867674 2048  2-361 4735 Gly-4 to His-11, H0031: 1 and L0747: Val-61 to Gly-67. 1. HPMEG77 772503 2049 214-366 4736 Leu-21 to Val-36, L0604: 3 and H0031: Pro-38 to Gln-44. 1. HPMDQ89 880787 2050  1-390 4737 Arg-1 to Phe-9, L0794: 2 and H0031: Arg-69 to Gln-83, 1. Lys-85 to Leu-103, Val-117 to His-122. HPMDP10 968350 2051  1-258 4738 Gly-1 to Gln-7, L0794: 2, H0031: 1 Gly-21 to Val-26, and L0779: 1. Arg-47 to Arg-55, Lys-71 to Ala-77. HPMDF06 954567 2052  1-111 4739 H0031: 1 and L0455: 1. HPMAM93 791407 2053 150-1  4740 Lys-42 to Ile-50. L0439: 2 and H0031: 1. HPMAL77 772740 2054 629-426 4741 L0748: 3, H0031: 1 and L0731: 1. HPMAL73 764752 2055  2-169 4742 Ser-2 to Tyr-15. H0031: 1 and L0745: 1. HPMAK71 503690 2056 232-442 4743 Leu-7 to Leu-12, H0031: 1 Asn-14 to His-27, Pro-30 to Lys-37. HPMAJ83 781518 2057 156-410 4744 H0031: 1 and L0748: 1. HPMAI80 572808 2058  2-154 4745 Arg-27 to Thr-46. H0031: 1 HPMAI10 968695 2059 215-63  4746 H0031: 1 HPMAH85 783344 2060  84-233 4747 Lys-1 to Lys-8. H0031: 1 and L0740: 1. HPMAH56 867711 2061 156-296 4748 H0031: 1 HPMAB10 968723 2062  3-221 4749 Pro-3 to Gly-11, H0031: 1 and L0758: Ser-43 to Leu-55. 1. HPLBW22 679217 2063  3-278 4750 Glu-8 to His-17, H0030: 1 and L0595: Gln-19 to Gly-43, 1. Thr-62 to Ser-73, Pro-80 to Leu-85. HPLBW02 921331 2064 338-499 4751 L0777: 2 and H0030: 1. HPLBT54 731065 2065 179-343 4752 Pro-1 to Ala-12, H0030: 1 and L0754: Gly-33 to Gln-38. 1. HPLBT53 728517 2066 283-450 4753 Ile-36 to Gly-47. H0030: 1 and L0758: 1. HPLBS41 712707 2067 359-559 4754 Pro-16 to Ser-23. L0747: 2 and H0030: 1. HPLBQ96 796069 2068  18-155 4755 Lys-6 to Asn-12. H0030: 1 and L0754: 1. HPLBO90 787208 2069 202-348 4756 Leu-30 to Cys-39. H0030: 1 and L0751: 1. HPLBN79 781854 2070 144-326 4757 Glu-4 to Arg-9, H0030: 1 and L0756: Thr-17 to Lys-23. 1. HPLBB47 975477 2071 745-491 4758 Lys-22 to Ser-39. L0518: 2, H0030: 1 and L0740: 1. HPLAX14 727885 2072  85-489 4759 Ser-7 to Gly-15, H0030: 1, L0747: 1 Pro-66 to Trp-73, and L0750: 1. Thr-96 to Gly-101, Gly-109 to Arg-133. HPLAV44 715732 2073 197-3  4760 His-23 to Asn-37. H0030: 1 and L0748: 1. HPLAI10 968707 2074  54-461 4761 Ser-14 to Phe-20. H0030: 1, L0517: 1, L0740: 1, L0754: 1, L0777: 1, L0755: 1 and L0758: 1. 968711 2675 659-372 5362 Leu-3 to Lys-8, Arg-27 to Ser-34, Leu-45 to Lys-55. HPJFA10 963322 2075 466-341 4762 Gln-9 to Ala-15. L0783: 1, L0809: 1 and S0152: 1. HPJEV95 929723 2076  82-408 4763 AR061: 4, AR089: 1 S0152: 1 and L0601: 1, HPJEU01 928408 2077 209-352 4764 S0152: 1 and L0439: 1. HPJET11 965894 2078 136-327 4765 Lys-35 to Lys-42. L0717: 1, S0152: 1 and L0756: 1. HPJES17 859867 2079  19-318 4766 Glu-8 to Cys-16. L0435: 1, S0152: 1, L0439: 1 and L0747: 1. HPJEL02 918315 2080  50-220 4767 Pro-26 to Phe-35. S0152: 1 and L0745: 1. HPJEG53 974074 2081  19-198 4768 S0152: 1 HPJDW93 867759 2082  44-406 4769 S0152: 1 and L0604: 1. HPJDT03 922815 2083 177-392 4770 S0152: 1 and L0759: 1. HPJDP54 949149 2084 155-301 4771 L0532: 1 and S0152: 1. HPJDF61 889928 2085 280-417 4772 AR054: 38, AR051: 29, AR050: 28 S0152: 1 HPJDC01 915056 2086 212-358 4773 Asn-17 to Met-22. S0152: 1 and L0779: 1. HPJDA25 951281 2087 246-506 4774 Gln-1 to Cys-17, AR061: 6, AR089: 2 Gln-20 to Lys-28, S0152: 1 Pro-35 to Ser-44. 951284 2676 252-13  5363 HPJCU29 928407 2088  1-195 4775 L0667: 1 and S0152: 1. HPJCT81 494874 2089 148-396 4776 Thr-2 to Asn-8, S0152: 1 and L0605: 1. Asn-49 to Ser-54. HPJCT26 559949 2090 210-635 4777 Arg-1 to Gly-7. AR054: 34 S0152: 1 HPJCS73 975087 2091  3-227 4778 Ser-33 to Lys-41. S0152: 1 HPJCS43 715082 2092  62-322 4779 Pro-10 to Ser-17, S0152: 1 Ser-19 to Arg-24, Pro-43 to Glu-50, Arg-56 to Phe-64, Pro-74 to His-87. HPJCS32 699046 2093 179-274 4780 Val-23 to Leu-31. S0152: 1 HPJCN60 887600 2094  1-210 4781 Ile-20 to Trp-33, AR051: 17, AR050: 9, Thr-35 to Gly-45. AR054: 8 S0152: 1 HPJCL55 670083 2095 458-291 4782 Glu-11 to His-16. L0758: 3, L0779: 2 and S0152: 1. HPJBU40 710928 2096 137-373 4783 L0748: 2 and S0152: 1. HPJBU09 625362 2097  3-182 4784 Arg-14 to Cys-22. L0439: 2 and S0152: 1. HPJBS74 765390 2098 310-591 4785 S0152: 1 and L0592: 1. HPJBS52 726535 2099 141-518 4786 Phe-2 to Asp-8. S0152: 1 and L0743: 1. HPJBS35 867818 2100  64-249 4787 S0152: 1 and L0748: 1. HPJBL76 769889 2101 240-546 4788 S0152: 1, L0740: 1 and L0750: 1. HPJBL30 948721 2102 354-145 4789 Tyr-10 to Leu-15, L0752: 7, L0780: 2, Glu-32 to Gly-41. L0586: 1 and S0152: 1. HPJBK25 974606 21032  17-154 4790 His-15 to Gln-26, S0152: 1 Ser-38 to Asn-46. HPJBK14 974593 2104  2-331 4791 Pro-8 to Leu-18, S0152: 1 Gly-45 to Ala-53, Pro-56 to Trp-63, Pro-67 to Arg-73. HPJBH45 717088 2105 252-404 4792 Ser-7 to Lys-12. L0754: 2 and S0152: 1 HPJAX30 607408 2106 762-544 4793 S0152: 1 884685 2677 104-370 5364 Ser-41 to Trp-46, Cys-57 to Gln-68, Tyr-79 to Gly-84. 885717 2678  643-1290 5365 HPJAU73 806718 2107 170-319 4794 S0152: 1 and L0748: 1. HPJAP92 887830 2108 164-322 4795 AR050: 26, AR051: 20, AR054: 10 S0152: 1 HPJAO13 824243 2109 716-531 4796 Ser-2 to Arg-7. AR061: 2, AR089: 1 S0152: 1 952302 2679  865-1110 5366 Gln-10 to Leu-26. 945194 2680 127-612 5367 HPJAN69 754858 2110  79-360 4797 Pro-75 to Phe-84. S0152: 1 HPJAN67 751384 2111  3-176 4798 S0152: 1 HPJAN57 734503 2112  65-166 4799 S0152: 1 HPJAJ20 669000 2113 476-652 4800 Thr-31 to Glu-37. S0152: 1 and L0439: 1. HPJAE51 725761 2114 193-2  4801 Ser-42 to Lys-48. L0439: 2 and S0152: 1. HPJAA27 419786 2115  3-278 4802 Leu-17 to Asn-31, S0152: 1 1q32.1 134580, Gly-55 to Ala-62, 145260, Arg-66 to Ala-87. 600105, 600759, 601975 HPICG93 887817 2116  20-310 4803 Leu-62 to Ser-75. AR051: 32, AR050; 26, AR054: 17 S0150: 1 HPICE06 935095 2117 607-816 4804 S0150: 1, L0439: 1 and L0740: 1 HPIBY36 708183 2118 296-517 4805 L0439: 2, L0756: 2, S0150: 1 and L0438: 1. HPIBT62 743135 2119 123-362 4806 S0150: 1, L0748: 1 and L0439: 1. HBIBO89 786741 2120 213-473 4807 Lys-79 to Phe-85. L0439: 3, S0150: 1, L0740: 1 and L0749: 1. HPIBI89 867845 2121  1-135 4808 Glu-7 to Ser-13. S0150: 1 and L0748: 1. HPIBH31 838809 2122 169-420 4809 Val-3 to Gly-14, S0150: 1 and L0748: 1. 2p22-p21 120435, Ser-65 to Gly-72. 120435, 126600, 135300, 136435, 152790, 152790, 157170, 182601, 278300, 601071, 601771, 602134 HPIBC93 785971 2123  1-285 4810 Ser-49 to Pro-54, S0150: 1 and L0751: 1. Pro-60 to His-70. HPIBB45 867850 2124  77-178 4811 S0150: 1 HPIBB43 715037 2125  47-247 4812 S0150: 1 HPIBB32 698901 2126  1-186 4813 S0150: 1 HPIBB19 668489 2127 182-289 4814 S0150: 1 HPIAW91 790033 2128 223-426 4815 Ala-6 to Ser-25. L0748: 2 and S0150: 1. HPIAV06 935111 2129  41-322 4816 Cys-19 to Trp-24, L0717: 2 and S0150: 1. Ser-29 to Glu-34, Phe-47 to Trp-52, Arg-57 to Gly-68. HPIAQ70 973604 2130 185-436 4817 Gly-36 to Thr-41. AR089: 18, AR061: 9 S0150: 1 HPIAP79 774817 2131 102-476 4818 Asp-7 to Thr-15. L0439: 6 and S0150: 1. HPIAD10 906987 2132 547-834 4819 Lys-91 to Pro-96. S0150: 1 and L0365: 1. 961313 2681 172-35  5368 HPHSB91 790313 2133 157-273 4820 Val-33 to Lys-39. S0176: 1 HPHSB21 671118 2134  52-189 4821 S0176: 1 HPHSA94 793084 2135  3-209 4822 S0176: 1 HPHAE81 778036 2136 417-127 4823 S0148: 1 and L0748: 1. 19q13.1 164731 172400, 172400, 180901, 180901, 221770, 248600, 600918, 602716 HPFMG06 933696 2137  1-120 4824 H0674: 1 and L0362: 1. HPFMB10 961758 2138 414-683 4825 Lys-2 to Lys-10. H0674: 1 and L0363: 1. HPFDX38 709302 2139 398-583 4826 H0169: 1 and L0766: 1. HPFCZ82 780198 2140  3-341 4827 Pro-108 to Gly-113. H0169: 1 and L0747: 1. HPFCZ60 430125 2141 298-444 4828 H0169: 1 and L0740: 1. HPFCZ10 968360 2142  33-272 4829 H0169: 1 HPFCR23 675120  93-263 4830 Thr-52 to Tyr-57. H0169: 1, L0809: 1 and L0754: 1. HPFCP82 867881 2144 435-632 4831 Pro-24 to Gly-44, AR050: 7, AR054: 3, Pro-47 to Tyr-56. AR051: 1 H0169: 1 HPFCP53 526574 2145 138-245 4832 AR050: 20, AR051: 4, AR054: 4 H0169: 1 HPFCM45 723501 2146  72-251 4833 H0169: 1, L0766: 1, L0776: 1, L0790: 1, L0741: 1 and L0779: . HPFCM27 682098 2147 178-294 4834 L0598: 2, H0169: 1 and L0731: 1. HPFCL56 732601 2148  20-187 4835 Cys-6 to His-17. H0169: 1 and L0777: 1. HPFCL24 867889 2149  56-274 4836 L0752: 2, H0169: 1, L0794: 1 and L0751: 1. HPFCG02 921196 2150  94-261 4837 Gly-33 to Arg-39. H0169: 1 and L0748: 1. HPFCA01 928672 2151 151-393 4838 Gly-18 to His-30. L0748: 2 and H0169: 1. HPELD12 969248 2152 231-623 4839 Gly-18 to Glu-29, H0673: 1, L0805: 1 Leu-55 to Gln-60, and L0731: 1. His-109 to Gly-117, Gly-122 to Pro-127. HPEKI04 926104 2153  43-165 4840 L0748: 2, H0673: 1 and L0749: 1. HPEKE01 914414 2154 159-350 4841 H0673: 1, L0769: 1 and L0768: 1. HPEBT82 524246 2155  1-111 4842 H0166: 1 HPEBT78 773844 2156  59-148 4843 Lys-15 to Gly-25. H0166: 1 HPEBT68 753692 2157  45-245 4844 Lys-9 to Trp-17. H0166: 1 HPEBT54 731002 2158  86-397 4845 Lys-26 to Cys-31, H0166: 1 Arg-38 to Asp-46. HPEBT49 530021 2159 106-300 4846 Leu-12 to Ser-17. H0166: 1 HPEBT34 706836 2160  44-301 4847 Asp-20 to His-27. H0166: 1 HPEBT14 535061 2161  3-98 4848 H0166: 1 HPEBT07 954214 2162  42-317 4849 Thr-78 to Arg-84. H0166: 1 HPEBO67 578516 2163  1-228 4850 Glu-12 to Thr-39. H0166: 1, L0748: 1 and L0747: 1. HPEBL08 960240 2164 227-313 4851 Lys-19 to Asn-27. L0770: 2, H0166: 1, L0665: 1 and L0749: 1. HPEBH01 921767 2165 105-341 4852 H0166: 1 and L0745: 1. HPEBG89 785942 2166  80-277 4853 Gly-2 to Cys-7, L0759: 2 and H0166: Glu-28 to Glu-40, 1. Glu-53 to Lys-58. HPEBG10 867888 2167  75-284 4854 Phe-26 to Trp-32. H0166: 1 and L0542: 1. HPEBA89 910250 2168 268-504 4855 Cys-14 to Ser-26, AR061: 57, AR089: 38 Glu-40 to Lys-58. H0166: 1 and L0749: 1. 912272 2682 182-361 5369 Cys-14 to Ser-26, Glu-40 to Lys-60. HPEBA61 742251 2169  2-70 4856 H0166: 1 HPEBA05 928027 2170  2-178 4857 Gly-14 to Ser-19. H0166: 1 and L0779: 1. HPEAG43 468542 2171  83-232 4858 H0165: 1 589933 2683  776-1117 5370 Pro-4 to Thr-17. HPEAD72 761472 2172  45-383 4859 H0165: 1 and L0744: 1. HPEAB12 968847 2173  2-178 4860 Ser-7 to Lys-13, L0794: 4 and H0165: Leu-29 to Ser-36. 1. HPEAA57 514231 2174 199-414 4861 Leu-11 to Ala-18, H0165: 1 Gly-22 to Ser-41. HPEAA40 867899 2175 186-308 4862 H0165: 1 and L0526: 1. HPDWR11 965249 2176 261-548 4863 Gly-1 to Thr-13, L0759: 2, L0769: 1, Arg-37 to Ser-45, L0768: 1, L0794: 1, Arg-52 to Asn-73. L0805: 1, H0658: 1, L0750: 1 and L0777: 1. HPDWN05 928563 2177 287-472 4864 L0439: 2, L0717: 1, L0803: 1, H0658: 1 and L0777: 1. HPDVM01 913859 2178 311-433 4865 L0779: 2 and H0658: 1. HPDVD11 965276 2179  25-117 4866 Ala-10 to Lys-18. H0658: 1 and L0779: 1. HPDRU11 965307 2180 118-342 4867 Gly-13 to Trp-21. H0658: 1 and L0756: 1. HPDRR06 968601 2181 448-74  4868 Pro-65 to His-76, L0666: 2, L0766: 1 Asn-110 to Phe-118. L0665: 1 and H0658: 1. HPDRN07 951838 2182  54-299 4869 Asp-11 to Asn-17. H0658: 1 and L0604: 1. HPDRG01 914416 2183 339-674 4870 L0748: 2, H0658: 1 and L0750: 1. HPDPS12 969342 2184  1-255 4871 Arg-10 to Gln-16, H0658: 1, L0777: 1 Pro-24 to Gly-30. and L0592: 1. HPDPP12 969341 2185  3-179 4872 Thr-1 to Asn-13, L0523: 1 and H0658: Pro-35 to Lys-42. 1. HPDPC08 957822 2186 120-398 4873 Arg-23 to Val-29. H0658: 1 13 HPDOW10 961782 2187 280-429 4874 Met-6 to His-12. L0766: 2, L0766: 2, H0658: 1 and L0779: 1. HPDOO10 961881 2188 338-520 4875 L0769: 3 and H0658: 1./ HPDOF11 965491 2189  30-227 4876 L0770: 2 and H0658: 1. HPCTK02 917480 2190 207-446 4877 H0659: 1, L0740: 1 and L0756: 1. HPCTD03 922149 2191  3-332 4878 AR089: 6, AR061: 2 H0659: 1 HPCTC04 925777 2192 150-347 4879 Arg-40 to Gln-47. L0659: 2, H0659: 1 and L0779: 1. HPCQQ07 951646 2193  2-328 4880 Arg-6 to Arg-11. L0805: 1, L0776: 1 and H0659: 1. HPCPM63 954940 2194  85-222 4881 L0800: 1, H0659: 1 and L0747: 1. HPCOV68 911075 2195  97-249 4882 AR089: 23, AR061: 7 L0439: 2, L0369: 1 and H0659: 1. HPCAO89 946913 2196  1-369 4883 Pro-18 to Gln-28, AR050: 18, AR054: Gln-42 to Asn-49, 18, AR089: 5, AR051: Ser-72 to Arg-81. 4, AR061: 2 L0761: 1 and S0146: 1. HPCAK66 320415 2197  85-237 4884 Lys-9 to Tyr-14, S0146: 1 Glu-44 to His-50. HPCAG81 778177 2198 190-348 4885 S0146: 1 and L0754: 1. HPCAF65 573368 2199  75-275 4886 Asp-38 to Ala-43. S0146: 1 HPCAD17 584754 2200 465-271 4887 Glu-16 to Glu-27, S0146: 1 Glu-35 to Ser-46, Glu-56 to Ala-64. 584755 2684 145-312 5371 HPCAB54 728857 2201  2-409 4888 Gly-1 to Gly-11. S0146: 1 and L0591: 1. HPCAB45 575233 2202  8-247 4889 Pro-21 to Thr-40. S0146: 1 HOVEV01 914553 2203  49-540 4890 Gly-50 to Thr-57, L0748: 3, L0603: 2, Gln-60 to Trp-74, H0428: 1, L0771: 1, Gln-86 to Cys-96, L0749: 1 and L0757: 1. Met-106 to Gly-124. HOVEU10 961865 2204 170-328 4891 H0428: 1 HOVEU06 933737 2205 106-201 4892 H0428: 1 HOVEO04 926209 2206  18-179 4893 Ser-27 to Gly-32. H0428: 1 and L0750: 1. HOVEE20 909030 2207  88-444 4894 Asn-7 to Met-12, AR089: 7, AR061: 2 Cys-38 to Thr-44. H0428: 1 HOVDD82 948619 2208  2-172 4895 Arg-2 to Cys-11, H0428: 1 and L0766: Cys-15 to Gly-20. 1. HOVDD10 961887 2209  3-323 4896 Glu-25 to Pro-39, H0428: 1 and L0462: Thr-44 to Tyr-50, 1. Pro-53 to Gln-60, Ser-67 to Val-82. HOVCP77 772210 2210 120-299 4897 Tyr-17 to Gln-23, L0439: 12 and H0428: Lys-32 to Ser-38. 1. HOVCO50 932544 2211 425-586 4898 H0428: 1, L0752: 1 and L0759: 1. HOVCN57 734779 2212 143-301 4899 Lys-1 to Gln-12 H0428: 1 and L0744: Cys-44 to Lys-49. 1. HOVCM77 772208 2213 107-265 4900 Arg-30 to Lys-39. H0428: 1 and L0439: 1. HOVCM03 924196 2214 159-257 4901 Glu-10 to Thr-18. H0428: 1 and L0750: 1. HOVCI89 786917 2215 194-322 4902 H0428: 1 HOVCI08 959470 2216 938-75  4903 Pro-43 to Ser-49. H0428: 1, L0743: 1, L0744: 1, L0747: 1, L0752: 1 and L0592: 1. HOVCD33 702445 2217 124-252 4904 Asp-33 to Val-38. L0439: 2 and H0428: 1. HOVCC57 465313 2218 210-380 4905 H0428: 1 and L0581: 1. HOVBQ07 858863 2219 200-604 4906 Asp-1 to Val-13, H0428: 1, L0764: 1 Ser-17 to Ser-26. and L0758: 1. HOVBK69 757594 2220 116-424 4907 H0428: 1 and L0740: 1. HOVBK38 956238 2221  33-263 4908 L0766: 2, H0428: 1, L0775: 1, L0782: 1, L0783: 1. L0748: 1 and L0758: 1. HOVBK24 858857 2222  75-353 4909 Gln-1 to Leu-7, H0428: 1, L0748: 1 Ser-32 to His-42. and L0581: 1. HOVBI67 751665 2223 155-355 4910 L0749: 2 and H0428: 1. HOVBI20 669730 2224  1-183 4911 H0428: 1 and L0748: 1. HOVAZ89 904818 2225  2-298 4912 Glu-14 to Pro-19, H0428: 1 Arg-24 to Arg-36, Arg-85 to His-90. HOVAZ65 750273 2226 275-457 4913 L0740: 2 and H0428: 1. HOVAY88 827077 2227 203-409 4914 Asn-20 to Lys-25. H0428: 1 HOVAY58 736077 2228 179-388 4915 Val-1 to Thr-11, H0428: 1 and L0754: Tyr-23 to Leu-31, 1. Arg-47 to Thr-52. HOVAY42 713812 2229 168-320 4916 Asn-20 to Glu-26. H0428: 1 HOVAY03 921959 2230 147-1  4917 H0428: 1 HOVAW62 745704 2231  2-247 4918 L0516: 2, H0428: 1 and L0753: 1. HOVAO25 678163 2232 112-270 4919 H0428: 1 and L0748: 1. HOVAN51 725005 2233  3-122 4920 L0748: 5, H0428: 1 and L0749: 1. HOVAJ07 953422 2234 279-452 4921 Lys-40 to Phe-47. H0428: 1 and L0743: 1. HOVAI05 932093 2235  2-199 4922 Val-41 to Lys-46. H0428: 1 and L0752: 1. HOVAF07 953553 2236  22-102 4923 H0428: 1 HOVAF01 916770 2237 245-3  4924 Phe-58 to Arg-67, H0428: 1 Leu-71 to Thr-77. HOVAC77 578783 2238 181-366 4925 H0428: 1 HOVAC54 578809 2239  36-197 4926 Ile-23 to Cys-35. H0428: 1 and L0748: 1. HOVAC26 578810  45-278 4927 Gln-12 to Gly-17, H0428: 1 Ser-28 to Pro-39. HOVAB85 578788 2241  3-407 4928 Asp-1 to Arg-6, H0428: 1 Thr-31 to Leu-43, Val-53 to His-59, Pro-61 to Val-73, Ser-81 to Ser-96. HOVAB61 578791 2242 256-477 4929 L0756: 2, L0361: 2, H0428: 1, L0598: 1 and L0592: 1, HOOKF10 961499 2243 210-359 4930 Lys-38 to Lys-50. L0776: 1 and H0648: 1. HOOKF04 925784 2244 508-239 4931 Thr-31 to Lys-40. L0758: 3, L0779: 2, H0648: 1 and L0740: 1. HOOJU04 925774 2245  17-283 4932 H0648: 1 and L0777: 1. HOOJN04 925783 2246  3-260 4933 Arg-21 to Leu-27. L0770: 1, L0794: 1, L0804: 1 and H0648: 1. HOOJK11 965292 2247 205-420 4934 Pro-48 to Phe-72. H0648: 1 and L0750: 1. HOOJH05 928627 2248  37-210 4935 Val-16 to Thr-26, L0758: 3 and H0648: Pro-30 to Ser-36, 1. Pro-53 to Glu-58. HOOJE02 917454 2249 248-379 4936 Lys-34 to Gly-41. H0648: 1 and L0758: 1. HOOIL05 928644 2250 280-444 4937 Pro-42 to Asp-55. L0751: 3, L0764: 1, L0518: 1, H0648: 1, L0747: 1 and L0752: 1. HOOIG03 922510 2251  2-205 4938 Glu-34 to Glu-44. H0648: 1 and L0596: 1. HOOHP02 917424 2252 210-374 4939 Phe-13 to Gln-24. H0648: 1, L0748: 1, L0751: 1, L0754: 1 and L0749: 1. HOOHE67 969061 2253  1-171 4940 H0648: 1, L0754: 1 and L0750: 1. HOOHD06 933873 2254  1-150 4941 Arg-1 to Cys-10, L0666: 1 and H0648: Lys-17 to Gly-24. 1. HOOAB23 522227 2255 249-49  4942 His-1 to Gln-7, H0028: 1 and L0792: Gly-14 to Gly-23, 1. Leu-50 to Arg-67. HOOAB05 932925 2256 196-579 4943 Ser-66 to Pro-76. H0028: 1 and L0777: 1. HONAK10 968610 2257  3-116 4944 Glu-1 to Lys-6. L0766: 1 and T0068: 1. HONAH06 936029 2258 677-333 4945 AR051: 655, AR050: 494, AR054: 346 T0068: 1 HONAE50 723571 2259 344-559 4946 Gly-18 to Thr-32. T0068: 1 and L0749: 1. HONAD65 747152 2260 174-290 4947 Ser-6 to Lys-14. T0068: 1 and L0592: 1. HONAD02 859016 2261  732-1040 4948 AR061: 1, AR089: 1 T0068: 1 and L0779: 1. HOGEW23 973221 2262  2-145 4949 Ser-1 to Gly-11. H0435: 1 HOGDQ03 922578 2263 163-414 4950 L0774: 1 and H0435: 1. HOGCW89 973227 2264 484-732 4951 Lys-10 to Asn-16. H0435: 1 HOGCT13 657284 2265 389-763 4952 L0439: 2 and H0435: 1. HOGCR31 463874 2266 205-441 4953 H0435: 1 and L0743: 1. HOGCR10 964761 2267  1-240 4954 H0435: 1 and L0748: 1. HOGCQ54 859076 2268  3-608 4955 Ser-19 to Asp-31. L0766: 3 and H0435: 1. HOGCH05 930813 2269  2-202 4956 H0435: 1 and L0748: 9q31.2 223900, 1. 253800, 253800 HOGCE07 859077 2270 126-509 4957 L0369: 1 and H0435: 1. HOGCD61 761991 2271 247-393 4958 H0435: 1 HOGCC63 745130 2272 101-241 4959 Gly-2 to Tyr-8. L0745: 2 and H0435: 1. HOGCA65 750308 2273 298-501 4960 Arg-8 to Leu-17. L0748: 2 and H0435: 1. HOGBJ26 847191 2274 208-50  4961 Ser-17 to Trp-23. H0435: 1 and L0439: 1. HOGBE27 682232 2275  2-163 4962 Arg-1 to Phe-13. H0435: 1 and L0747: 1. HOGAM56 908904 2276 973-779 4963 H0435: 1 HOGAI73 764490 2277 227-379 4964 Lys-3 to Phe-8. H0435: 1 and L0777: 1. HOGAI26 681919 2278 221-397 4965 Arg-1 to Gly-19, L0748: 2 and H0435: Lys-35 to Trp-43. 1. HOGAH71 760431 2279 163-369 4966 Asp-22 to His-28, H0435: 1 and L0596: Arg-49 to Ser-54. 1. HOGAG57 734848 2280  2-634 4967 Lys-10 to Ser-15, L0747: 2, H0435: 1, Arg-44 to Ser-62, L0742: 1, L0596: 1 and Glu-78 to Thr-83, L0591: 1. Lys-115 to Phe-124, Glu-137 to Asp-148, Gly-165 to His-171, Glu-189 to Lys-211. HOGAD77 772319 2281 298-576 4968 L0748: 2 and H0435: 1. HOGAC69 756713 2282 578-324 4969 H0435: 1 HOFNW81 789232 2283  46-336 4970 Asp-48 to Glu-53, H0415: 1 Pro-72 to Ser-81. HOFNW69 533713 2284 213-28  4971 Glu-17 to His-23, H0415: 1 1q21 104770, His-26 to Ser-34, 107670, Gly-40 to Glu-45. 110700, 135940, 145001, 146790, 152445, 152445, 159001, 174000, 179755, 182860, 182860, 182860, 191315, 230800, 230800, 266200, 600897, 601105, 601412, 601652, 602491 HOFNW68 753048 2285  1-132 4972 Lys-18 to Asp-23. H0415: 1 HOFNW65 815822 2286  3-431 4973 Arg-14 to Asn-19, AR089: 5, AR061: 3 Ala-35 to Ser-45, H0415: 1 Gln-74 to Glu-90. HOFNW45 720755 2287  2-118 4974 Asn-12 to Glu-19, H0415: 1 Lys-30 to Phe-35. HOFNW07 953436 2288  37-411 4975 Arg-10 to Arg-19, H0415: 1 Asn-50 to Ser-61, Met-65 to Lys-71, Ala-83 to Asn-89. HOFNU50 724437 2289  3-347 4976 Phe-5 to Pro-10, L0748: 2 and H0415: Gln-71 to Ser-77, 1. Lys-86 to Glu-91. HOFNL96 888569 2290  3-380 4977 Pro-3 to Ala-17, H0415: 1 Asn-56 to Asp-62, Gln-85 to Gly-100. HOFNI90 788947 2291  90-323 4978 Gln-1 to Ser-6, H0415: 1 Ser-36 to Ser-45, Leu-47 to Pro-54, Arg-59 to Gly-69. HOFNI85 784366 2292  1-138 4979 H0415: 1 HOFNI72 760643 2293  52-273 4980 H0415: 1 HOFNI71 760392 2294  59-253 4981 Arg-1 to Arg-6. H0415: 1 773729 2685  1-177 5372 Gly-9 to His-30, Arg-48 to Pro-57. HOFNI58 859094 2295 151-351 4982 H0415: 1 HOFNI56 859093 2296 166-408 4983 Gln-7 to Gly-15. H0415: 1 HOFNI42 713813 2297 111-302 4984 H0415: 1 HOFNI37 859102 2298  35-232 4985 H0415: 1 HOFNI33 859103 2299  3-263 4986 H0415: 1 HOFNI32 699299 2300  2-217 4987 Gly-1 to Gly-11, H0415: 1 Thr-59 to Gly-64. HOFNI10 964682 2301  2-193 4988 H0415: 1 HOFNI02 917347 2302  1-201 4989 Gln-16 to Gln-23. H0415: 1 HOFNC80 835718 2303  1-315 4990 Ser-9 to Lys-18. AR051: 12, AR050: 12, AR054: 10, AR061: 2, AR089: 1 H0415: 1 HOFNC79 774037 2304 139-243 4991 Glu-21 to Asp-26. H0415: 1 HOFNB63 613681 2305 179-3  4992 H0415: 1 HOFNB55 731801 2306  2-67 4993 Arg-1 to Thr-15. H0415: 1 HOFNB51 725684 2307 187-432 4994 Arg-18 to Lys-24 H0415: 1 HOFMU70 489858 2308  2-154 4995 Arg-18 to Gly-24. H0415: 1 HOFMU67 743184 2309 256-528 4996 Gln-85 to Pro-91. H0415: 1 HOFMU29 824242 2310 993-625 4997 H0415: 1 902061 2686 217-402 5373 HOFMT55 888552 2311  87-239 4998 Val-17 to Glu-24. AR050: 84, AR054: 73, AR051: 55, AR089: 21, AR061: 8 H0415: 1 HOFMT45 891512 2312  3-269 4999 Asp-1 to Leu-10, AR051: 10, AR054: 9, Glu-38 to Cys-74. AR050: 2 H0415: 1 HOFMS43 947973 2313  3-359 5000 Asp-1 to Asp-17, AR051: 15, AR050: 9, Pro-61 to Asn-66, AR089: 7, AR061: 5, Tyr-84 to Tyr-90, AR054: 1 Ser-103 to Trp-110. H0415: 1 HOFMS09 972725 2314  3-461 5001 H0415: 1 HOFMP09 943358 2315  1-372 5002 Ala-74 to Gly-84, AR089: 20, AR061: 9 Arg-98 to Lys-104. H0415: 1 HOFMI25 491360 2316 145-2  5003 Lys-28 to Val-33, H0415: 1 Gln-40 to Gly-48. 859125 2687  3-839 5374 Asn-33 to Leu-38. HOFMF82 693987 2317  2-169 5004 Thr-1 to Lys-7, AR089: 2, AR061: 1 Ala-17 to Arg-33, His 35 to Asn-45, Glu-47 to Arg-52. 694062 2688  3-476 5375 Phe-8 to Ser-21, Ile-28 to Arg-33, Ile-40 to Gly-49, Ala-56 to Gln-61, Gln-69 to Ser-76, Ala-91 to Tyr-96, Thr-119 to Cys-126, Ser-132 to Arg-144, Thr-147 to Asp-158. 909248 2689  1-447 5376 Arg-17 to Leu-32, His-43 to Cys-54. HOFMF81 788733 2318  3-395 5005 Asp-1 to Asn-6, H0415: 1 Met-46 to Phe-53. HOFMF19 888780 2319  2-397 5006 Arg-1 to Gly-14, AR050: 21, AR051: Glu-35 to Leu-42, 10, AR054: 9 Thr-54 to Lys-61. H0415: 1 HOFAF25 942367 2320 271-993 5007 H0414: 1 HOFAD78 886485 2321  3-527 5008 Pro-19 to Arg-27, AR054: 15, AR051: 3, Ser-36 to Asn-42, AR050: 0 His-101 to Pro-107, H0414: 1 Gly-150 to Gln-155, Ser-167 to Thr-175. HODKG07 951875 2322  3-143 5009 Gly-13 to Ser-20, L0623: 2, H0615: 1 Arg-41 to Thr-47. and L0519: 1. HODJU05 929321 2323  91-309 5010 Arg-52 to Asn-61. H0615: 1, L0435: 1 and L0759: 1. HODJL04 926200 2324 128-328 5011 H615: 1, L0520: 1 and L0766: 1. HODHK07 952193 2325 114-278 5012 Thr-26 to Ser-33. H0615: 1 and L0754: 1. HODHG11 966063 2326 338-610 5013 Arg-1 to Val-10, H0615: 1 and L0758: Trp-12 to Tyr-20, 1. Arg-47 to Ser-63. HODGL88 859300 2327 461-610 5014 Arg-8 to Arg-16. L0471: 1, H0615: 1, L0748: 1 and L0749: 1. HODGJ02 918476 2328 237-368 5015 L0471: 1, H0615: 1 and L0748: 1 HODFY10 963350 2329 122-358 5016 Asn-1 to Asp-6, L0777: 2 and H0615: Phe-8 to Ser-14. 1. HODFX19 842138 2330  3-494 5017 Pro-15 to Gly-24, H0615: 1 and L0775: Cys-36 to Ile-44, 1. Arg-77 to Pro-112. HODFX12 969588 2331  3-170 5018 Ser-17 to Gln-29. H0615: 1 and L0666: 1. HODFX04 926278 2332 222-491 5019 Ser-2 to Ile-16. H0615: 1, L0775: 1 and L0748: 1. HODFW95 795281 2333  3-563 5020 His-1 to Arg-7, L0747: 2 and H0615: Ala-45 to Arg-52, 1. Ser-75 to Leu-80, Arg-89 to Asp-94, Arg-139 to Glu-158. HODFW40 859320 2334 386-556 5021 H0615: 1, L0805: 1 and L0776: 1. HODFR85 783789 2335  35-199 5022 H0615: 1 and L0756: 1. HODFL37 948703 2336 239-463 5023 Lys-1 to Thr-22. H0615: 1 HODFJ11 966065 2337 326-460 5024 L0777: 2 and H0615: 1. HODFI66 974317 2338  81-338 5025 H0615: 1 HODFH45 974916 2339 453-593 5026 H0615: 1 HODFG82 779191 2340  1-150 5027 H0615: 1 and L0362: 1. HODFF88 974911 2341  14-544 5028 His-8 to Gly-18, AR054: 34, AR051: Glu-150 to Leu-167. 29, AR050: 23, AR089: 4, AR061: 4 H0615: 1 HODFE04 926999 2342  85-249 5029 H0615: 1 and L0748: 1. HODFD73 909812 2343  1-576 5030 AR061: 10, AR089: 4 H0615: 1 HODFC79 774156 2344  66-242 5031 Thr-47 to Lys-53. H0615: 1 and L0749: 1. HODEZ45 974337 2345 215-436 5032 His-34 to Trp-39. H0615: 1 HODEU01 915167 2346  2-286 5033 L0748: 3 and H0615: 1. HODET07 952194 2347 354-127 5034 H0615: 1 and L0748: 1. HODES10 963474 2348  90-200 5035 L0534: 1 and H0615: 1. HODEO35 859364 2349  2-136 5036 H0615: 1, L0376: 1 and L0759: 1. HODEK82 779245 2350 450-596 5037 Leu-1 to Phe-8. H0615: 1 and L0753: 1. HODEA14 859375 2351  3-527 5038 H0615: 1, L0060: 1 and L0462: 1. HODDX64 745810 2352  73-393 5039 H0328: 1 and L0748: 1. HODDS89 531075 2353 301-453 5040 Thr-1 to Val-7. H0328: 1 and L0756: 1. HODDS74 765863 2354  83-235 5041 Arg-21 to Phe-27, H0328: 1 and L0748: Ser-45 to Trp-50. 1. HODDF37 420051 2355 271-420 5042 H0328: 1 704622 2690 173-481 5377 Pro-46 to Tyr-51. HODDE02 920961 2356  3-200 5043 Asp-1 to Asp-8. H0328: 1, L0373: 1 and L0777: 1. HODCZ64 745966 2357  71-208 5044 Pro-35 to Lys-46. AR051: 30, AR050: 10 H0328: 1 HODCZ39 875811 2358  3-203 5045 H0328: 1, L0748: 1 and L0596: 1 HODCY73 764543 2359 214-414 5046 Asn-36 to Thr-47. H0328: 1, L0748: 1 and L0439: 1. HODCY32 859543 2360 212-352 5047 H0328: 1 HODCW83 781287 2361  40-207 5048 H0328: 1 and L0777: 1. HODCV61 868291 2362 187-393 5049 H0328: 1 HODCO15 660502 2363  82-219 5050 H0328: 1 and L0748: 1. HODCJ84 973286 2364 2 28-354 5051 Ser-51 to Leu-56, H0328: 1 Ser-84 to Leu-90. HODCC05 932633 2365 397-552 5052 Val-10 to Glu-16. H0328: 1, L0455: 1 and L0777: 1. HODCA90 792611 2366  62-313 5053 Asn-44 to Asn-51. H0328: 1 and L0749: 1. HODBZ85 784526 2367  60-236 5054 H0328: 1 and L0748: 1. HODBX08 960178 2368 344-595 5055 Pro-43 to Ser-54. H0328: 1, L0527: 1 and L0749: 1. HODBU72 766284 2369  99-266 5056 Pro-33 to Phe-39, L0598: 2 and H0328: Tyr-50 to Ser-56. 1. HODBK84 859558 2370 203-460 5057 Gly-1 to Ser-17. AR051: 91, AR050: 61, AR054: 56 H0328: 1 HODBF61 742114 2371  1-159 5058 Tyr-35 to Ile-42. H0328: 1 HODBF40 529387 2372  24-215 5059 H0328: 1 HODBF33 702750 2373  2-193 5060 Leu-1 to Gly-12. L0794: 2, L0750: 2, H0328: 1, L0766: 1, L0803: 1, L0788: 1 and L0755: 1. HODBF17 529389 2374 196-336 5061 H0328: 1 and L0792: 1. HODBD93 792579 2375 126-308 5062 His-1 to Gly-6, L0731: 2 and H0328: Cys-9 to Thr-18. 1. HODBD73 764670 2376 104-340 5063 Thr-8 to Arg-14, H0328: 1 and L0748: Ser-37 to Glu-42. 1. HODBC42 529635 2377 280-486 5064 Ser-8 to Ser-13. L0731: 3 and H0328: 1. HODBA48 721931 2378  18-257 5065 L0745: 2, H0328: 1, L0740: 1 and L0759: 1 HODAZ21 826693 2379  2-205 5066 Glu-1 to Gly-13, H0328: 1 Gly-21 to Thr-28, Lys-43 to Asn-61. HODAX45 723449 2380  2-103 5067 Pro-1 to Gly-12. L0748: 2 and H0328: 1. HODAV84 592179 2381  43-210 5068 Lys-1 to Ser-7. H0328: 1 HODAV24 679165 2382 177-308 5069 L0748: 3, L0740: 2, H0328: 1, L0766: 1, L0803: 1, L0659: 1, L0665: 1 and L0612: 1. HODAK55 745532 2383  2-169 5070 AR061: 11, AR089: 9 9p13-p12 230400, L0748: 3 and H0328: 250250 1. HODAK05 932639 2384  2-133 5071 Arg-15 to Thr-22, H0328: 1 and L0596: Ser-28 to Arg-33. 1. HODAE72 529638 2385  2-135 5072 H0328: 1 HODAE55 529637 2386  2-117 5073 H0328: 1 HODAE48 529639 2387  21-101 5074 Asp-1 to Arg-8. H0328: 1 HODAE01 921680 2388  92-319 5075 H0328: 1 and L0748: 1. HODAA92 790588 2389  77-253 5076 Pro-1 to Gly-20, H0328: 1 Ser-27 to Ser-34. HODAA85 784534 2390  3-167 5077 H0328: 1 HODAA80 529560 2391  2-298 5078 H0328: 1 HODAA69 529563 2392 113-238 5079 H0328: 1 HODAA54 859582 2393  64-198 5080 Tyr-15 to Gln-27. H0328: 1 HODAA34 529570 2394  93-251 5081 Lys-42 to Thr-47. H0328: 1 HODAA21 859583 2395  49-198 5082 H0328: 1 and L0605: 1. HODAA15 523382 2396  84-131 5083 H0328: 1 HODAA07 954157 2397  21-107 5084 H0328: 1 HODAA04 927711 2398  58-303 5085 H0328: 1 HOCPU05 928651 2399 114-377 5086 L0755: 2, L0758: 2, L0717: 1, L0365: 1 and H0660: 1. HOCPH02 917453 2400 139-327 5087 Arg-14 to Cys-20, L0748: 2, L0756: 2, Val-34 to Cys-43, L0372: 1, L0663: 1, Pro-45 to Ser-52. L0665: 1, H0660: 1, L0439: 1 and L0777: 1. HOCPF02 917630 2401  49 240 5088 Ser-18 to Ser-27. L0766: 1, H0660: 1 and L0758: 1. HOCOV07 951744 2402 108-314 5089 Phe-19 to Tyr-34, L0766: 3 and H0660: Ser-41 to Arg-51. 1. HOCMM01 914464 2403 112-390 5090 Ser-19 to Tyr-28, L0763: 1, L0776: 1 and Glu-34 to Val-45, H0660: 1. Gly-53 to Pro-58, Glu-63 to Gln-82. HOCMI24 878363 2404  2-484 5091 Asp-21 to Leu-45. H0660: 1 and L0731: 1. HOCMC01 914552 2405 432-136 5092 Pro-31 to Gly-36, H0660: 1 and L0749: Ser-60 to Leu-65, 1. Gln-69 to Thr-76, Gly-81 to Glu-87. HNOJJ12 969077 2406 1517-1771 5093 H0687: 1, L0803: 1 and L0666: 1. HNOAD04 926258 2407 464-625 5094 Thr-12 to Ser-19, L0766: 4, L0439: 4, Lys-28 to Ala-39. L0646: 1, H0651: 1, L0756: 1 and L0759: 1. HNNNB08 957719 2408 358-161 5095 H0678: 1 HNNNA07 899742 2409 588-361 5096 AR051: 4, AR054: 0 H0678: 1 HNIAB92 683077 2410 111-1  5097 Gln-27 to Asn-35. S0326: 1 HNIAB73 764172 2411  2-346 5098 S0326: 1 HNIAB26 974750 2412 387-73  5099 Arg-14 to Trp-19. S0326: 1, L0769: 1 and L0774: 1. HNBVH02 917719 2413  91-192 5100 H0662: 1 and L0748: 1. HNBVC03 922402 2414  3-104 5101 Tyr-6 to Thr-15. H0662: 1 and L0766: 1. HNBUQ06 933673 2415 321-521 5102 Glu-1 to Tyr-7, H0662: 1, L0794: 1 Pro-42 to Leu-47, and L0758: 1. Pro-50 to Ala-57. HNBUO01 914361 2416 109-336 5103 His-1 to Phe-6, H0662: 1 and L0524: Asn-58 to Met-65. 1. HNBUI10 961734 2417  3-437 5104 Pro-6 to Cys-24, H0662: 1, L0764: 1, Glu-26 to Trp-37, L0803: 1, L0774: 1, Asn-65 to Leu-73, L0758: 1 and L0599: 1. Gln-81 to Gly-90, Gly-100 to Gly-115, Asn-118 to Ser-126. HLWFJ69 754476 2418  3-245 5105 H0553: 1 and L0754: 12q13.3 181430, 1. 232800, 600808, 601284, 601769, 601769, 602116 HLWFB01 915399 2419  56-328 5106 Lys-38 to Gly-43. H0553: 1 and L0794: 1. HLWEH10 963548 2420  1-204 5107 Gln-1 to Ala-17, L0617: 1 and H0553: Arg-47 to Gln-52. 1. HLWEA90 787632 2421 179-331 5108 Lys-1 to Thr-6, H0553: 1 and L0747: Ser-32 to Ser-38. 1. HLWDZ31 917643 2422  2-259 5109 H0553: 1 and L0758: 20q13.1 256540, 1. 600281, 600281 HLWDD01 915378 2423  1-216 5110 Trp-5 to Lys-11. H0553: 1 and L0512: 1. HLWDB48 856512 2424 215-514 5111 Pro-31 to Gln-38, H0553: 1 and L0740: Ser-58 to Gly-69. 1. HLWCP60 739801 2425  1-207 5112 Phe-1 to Gly-6, H0553: 1 and L0596: Phe-40 to Gly-49. 1. HLWCN93 791854 2426 219-392 5113 Glu-4 to Ala-9. H0553: 1 and L0748: 1. HLWCN50 723787 2427  2-250 5114 Val-33 to Ser-38. H0553: 1 and L0756: 1. HLWCF83 781069 2428  1-297 5115 Pro-14 to Arg-26, H0553: 1 and L0752: Pro-28 to Ser-33, 1. Gly-48 to Ala-56. HLWCF33 687995 2429  3-503 5116 Leu-62 to Arg-69, H0553: 1, L0591: 1 Lys-76 to Phe-96. and L0595: 1. HLWCE47 720156 2430 278-466 5117 H0553: 1, L0783: 1 and L0749: 1. HLWCB93 623773 2431 278-3  5118 Pro-6 to Glu-18, H0553: 1 Pro-20 to Trp-40, Lys-86 to Arg-92. 856519 2691  3-200 5378 Ser-15 to Ser-23. HLWBX42 917920 2432  44-382 5119 Arg-11 to Ser-17. H0553: 1 and L0751: 1. HLWBW29 690515 2433  1-195 5120 Arg-2 to Gly-7, H0553: 1 and L0748: Ile-28 to Ile-34, Ser-56 to Val-62. HLWBT09 887877 2434  3-419 5121 Ser-1 to Glu-28. AR050: 49, AR054: 47, AR051: 27 H0553: 1 HLWBS62 743406 2435  9-365 5122 Gly-11 to Trp-16, H0553: 1, L0766: 1 Cys-53 to Gly-78, and L0747: 1. Arg-99 to Asp-105, Ser-113 to Glu-119. HLWBR85 784261 2436 221-370 5123 Lys-9 to Asn-22. L0747: 2 and H0553: 1. HLWBQ91 790072 2437  1-303 5124 H0553: 1 and L0748: 6q16.1-q16.3 136550, 1. 602772 HLWBJ65 747784 2438 270-467 5125 Leu-20 to Asp-38. H0553: 1 and L0759: 1. HLWBH92 791355 2439  95-301 5126 Glu-8 to Gln-18. H0553: 1 and L0754: 1. HLWBG78 888068 2440  39-371 5127 Pro-2 to Thr-7, H0553: 1 and L0748: Ala-13 to Arg-20. 1. HLWBF48 721530 2441 172-381 5128 Arg-12 to Gly-21. H0553: 1, L0665: 1, L0439: 1 and L0759: 1. HLWBE74 887967 2442  2-232 5129 Glu-7 to Glu-13, AR054: 15, AR050: 3, Trp-18 to Thr-32, AR051: 2 Pro-34 to Arg-44, H0553: 1 Gly-51 to Trp-60, Pro-62 to Ala-72. HLWBC21 869611 2443  2-412 5130 Pro-2 to Val-21, L0747: 2, H0553: 1 Asp-23 to Val-30, and L0794: 1. Gly-36 to Leu-41, Met-49 to Gly-55, Thr-72 to Lys-78, Ile-92 to Asp-97. HLWBA80 720397 2444  3-347 5131 Lys-6 to Leu-12, H0553: 1 and L0755: His-39 to Leu-57, 1. Ile-61 to Asp-66. HLWBA27 931387 2445  2-322 5132 Lys-6 to Asn-13, H0553: 1 and L0749: Gly-31 to Gly-36, 1. Glu-91 to Ser-99. HLWAW86 785395 2446  1-273 5133 Lys-11 to Arg-23, H0553: 1 and L0759: Cys-25 to Cys-31, 1. Pro-33 to Tyr-38, Arg-46 to Ile-60. 941397 2692 115-462 5379 Leu-17 to Gln-23, Gln-38 to Phe-44, Gln-65 to Gln-72, Thr-80 to Tyr-86. HLWAS09 625419 2447  74-235 5134 His-27 to Ile-34. H0553: 1 HLWAR08 959139 2448  3-290 5135 Tyr-46 to His-52. AR089: 4, AR061: 2 L0539: 1 and H0553: 1. HLWAO67 751503 2449  35-214 5136 H0553: 1 and L0745: 1. HLWAL31 948928 2450 124-2  5137 AR054: 55, AR050: 51, AR051: 48, AR089: 4, AR061: 2 H0553: 1 971312 2693  23-511 5380 Arg-9 to Pro-15, Leu-114 to Val-120, Cys-147 to Cys-156. HLWAJ18 666281 2451  41-214 5138 H0553: 1 and L0439: 20q12-q13 600281, 1. 600281 HLWAF02 919714 2452 156-449 5139 Arg-1 to Ser-6, H0553: 1 and L0758: Phe-13 to Gln-24, 1. Glu-31 to Arg-40, Ser-48 to Asn-56, Asp-69 to Val-75. HLWAE09 789030 2453 444-133 5140 Pro-21 to Gln-27, H0553: 1 and L0439: Glu-53 to Ser-60. 1. HLWAD57 734655 2454  2-166 5141 His-1 to Ala-7, H0553: 1 Thr-34 to Leu-39. HLWAD33 702317 2455 190-468 5142 Arg-1 to Arg-10, H0553: 1, L0754: 1 Ile-66 to Glu-78. and L0755: 1. HLWAD32 699158 2456  49-219 5143 Asn-42 to Lys-48. H0553: 1 HLWAD02 919725 2457  13-252 5144 Arg-2 to Phe-7, H0553: 1 and L0663: Thr-68 to Asn-73. 1. HKZAH11 965175 2458  1-324 5145 Gly-11 to Ile-17, L0794: 2, L0766: 1, Asn-24 to Ser-31, L0665: 1 and H0689: 1. Gln-47 to Ala-64, Pro-66 to Ala-72, Gly-77 to Gly-84. HJMBX19 668568 2459  2-286 5146 Leu-2 to Arg-11, L0777: 2, H0545: 1 Ser-25 to Gly-33, and L0754: 1. Lys-54 to His-64. HJMBS77 772101 2460 158-328 5147 Ser-48 to Lys-57. H0545: 1 and L0756: 1. HJMBS10 964464 2461  96-380 5148 Tyr-47 to Ser-58. H0545: 1 and L0599: 1. HJMBQ90 788834 2462 156-557 5149 Thr-17 to Gly-22, H0545: 1 and L0747: Gln-69 to Glu-74. 1. HJMBN02 919737 2463 218-436 5150 Arg-5 to Thr-16. H0545: 1 and L0763: 1. HJMBI93 929114 2464  47-199 5151 H0545: 1 and L0646: 1. HJMAV93 828110 2465 373-122 5152 Asn-74 to Pro-80. H0545: 1, L0748: 1 and L0740: 1. HJMAU07 961623 2466 187-501 5153 H0545: 1 and L0794: 16p13.3 141750, 1. 141800, 141800, 141800, 141800, 141850, 141850, 141850, 141850, 141850, 156850, 186580, 191092, 600140, 600273, 601313, 601785 HJMAQ86 785410 2467  1-234 5154 Pro-3 to Ser-16, L0588: 2, H0545: 1 Pro-27 to Gly-32, and L0603: 1. Pro-49 to Ala-58, Thr-70 to Lys-78. HJMAQ14 657579 2468 130-477 5155 L0163: 2, H0545: 1 and L0754: 1. HJMAJ91 811222 2469  78-452 5156 Arg-1 to Ser-15, H0545: 1 and L0740: Ser-18 to Ser-33, 1. Glu-42 to Arg-51. HJMAI62 742612 2470 195-356 5157 Gly-15 to Glu-21. H0545: 1 HETLF29 909762 2471  3-416 5158 AR061: 4, AR089: 2 H0046: 1 and L0758: 1. HETJY68 752542 2472 109-306 5159 H0046: 1, L0439: 1, L0740: 1 and L0591: 1. HETID12 655199 2473  13-321 5160 Pro-39 to Arg-44, H0046: 1 and L0731: Ala-89 to Glu-103. 1. HETHO01 921649 2474 218-415 L0748: 2, H0046: 1 and L0766: 1. HETHB18 529467 2475  2-247 5162 H0046: 1 HETFF68 529587 2476  2-166 5163 Asn-1 to Leu-13. H0046: 1 HETFF43 529589 2477  70-204 5164 H0046: 1 HETDU61 742157 2478 250-420 5165 Ala-39 to Cys-46. H0046: 1, L0748: 1 and L0581: 1. HETDA25 677490 2479 181-336 5166 H0046: 1 and L0439: 1. HETCO27 533536 2480  3-113 5167 Val-19 to Leu-35. H0046: 1 HETCH01 961038 2481  2-352 5168 Cys-11 to Pro-19, L0738: 1, H0046: 1, Asn-28 to Leu-35. L0527: 1 and L0599: 1. HETBM55 929285 2482 113-343 5169 Val-20 to Gly-26, L0747: 2 and H0046: 1q12-1q21.2 104770, Asn-62 to Arg-68. 1. 107670, 110700, 145001, 146760, 146790, 159001, 191315, 600897, 601412, 601652, 601863, 602491 HETBE61 965638 2483 124-447 5170 Glu-31 to Gly-37, H0046: 1 and L0731: 6q25 180020, Leu-42 to Gln-49. 1. 600320, 600883 HETAS91 790499 2484 237-548 5171 Ser-73 to Lys-91. L0740: 3 and H0046: 1. HETAS81 778539 2485  12-188 5172 Pro-17 to Ser-23. H0046: 1 and L0777: 1. HETAS62 754155 2486  14-187 5173 Ser-22 to Lys-31, H0046: 1 and L0748: Thr-39 to Glu-47. 1. HETAJ14 660831 2487 575-757 5174 Ala-24 to Ser-31, L0747: 2 and H0046: 1 Val-52 to Asp-61. and L0748: 1. HEQCC01 924849 2488 375-659 5175 Ser-54 to Ala-59, H0544: 1, L0775: 1, Ser-64 to Phe-69, L0776: 1 and L0758: 1, Arg-79 to Thr-87. HEQBT78 773528 2489 252-10  5176 H0544: 1 and L0731: 1. HEQBP18 855578 2490 463-245 5177 Thr-7 to Gly-14. H0544: 1 HEBQI09 739877 2491  29-142 5178 H0544: 1 HEQBG85 827915 2492  1-276 5179 H0544: 1 2qter-p25.1 HEQBG60 427813 2493  2-295 5180 Ser-1 to Pro-23, H0544: 1 17p13.3 113721, Pro-35 to Asn-45, 247200, Cys-53 to Arg-70. 600059, 601545 HEQBE78 772860 2494 101-265 5181 Asp-13 to Lys-20, H0544: 1 Thr-43 to Ala-49. HEQBE71 760305 2495 101-451 5182 Glu-18 to Pro-27, H0544: 1 Asp-58 to Asn-65. HEQAZ01 916321 2496  97-402 5183 Phe-2 to Gly-7. H0544: 1 and L0599: 1. HEQAM59 739220 2497  50-160 5184 H0544: 1 and L0752: 1. HEQAK94 793250 2498  2-298 5185 H0544: 1, L0439: 1 and L0754: 1. HEQAF54 729594 2499  3-200 5186 L0439: 2 and H0544: 1. HEQAD73 914044 2500  82-555 5187 Trp-1 to Ser-10. L0731: 5 and H0544: 1. HEQAA93 792255 2501 340-519 5188 Lys-6 to Arg-11, L0747: 3 and H0544: Thr-22 to Gly-34. 1. HEPCB04 941270 2502  72-305 5189 Ser-1 to Gln-9, L0777: 4, H0150: 1 Ser-16 to Cys-22, and L0757: 1. Ser-33 to Ser-38, Ser-58 to Trp-66. HEPBO92 952996 2503 146-349 5190 Arg-10 to Ser-18, H0150: 1 and L0747: Leu-37 to Arg-48. 1. HEPBO85 783362 2504  1-240 5191 L0754: 2 and H0150: 1. HEPAY26 825778 2505  29-193 5192 H0150: 1 and L0743: 1. HEPAX40 535627 2506  2-172 5193 L0744: 2, L0731: 2 and H0150: 1. HEPAX16 667665 2507  2-330 5194 L0766: 3, L0776: 2, 11p15.5 125852, H0150: 1, L0371: 1, 126452, L0761: 1, L0764: 1, 126452, L0662: 1, L0655: 1, 141900, L0748: 1, L0754: 1, 141900, L0749: 1 and L0779: 1. 141900, 141900, 141900, 141900, 142000, 142000, 142200, 142250, 142270, 176730, 176730, 176730, 190020, 191290, 192500, 192500, 194071, 194071, 204500, 600856, 601680, 602631, 602631 HEPAQ35 707533 2508 245-511 5195 L0748: 2, L0756: 2, L0777: 2, H0150: 1, L0789: 1, L0666: 1 and L0758: 1. HEPAP34 703336 2509 369-623 5196 Pro-17 to Val-26, H0150: 1 and L0777: His-34 to Lys-41, 1. Pro-54 to Phe-66 HEPAN05 932893 2510 223-489 5197 Lys-15 to Leu-29, H0150: 1 and L0780: Lys-45 to Glu-55, 1. Lys-82 to Lys-89. HEPAK04 933039 2511  4-177 5198 Leu-42 to Gly-54. H0150: 1 and L0763: 1. HEPAJ14 657440 2512  55-243 5199 His-1 to Ser-10, H0150: 1 and L0743: Pro-22 to Gly-38, 1. Asn-55 to Ser-60. HEPAJ04 933091 2513  71-367 5200 Thr-1 to Arg-16, H0150: 1, L0779: 1 Ala-45 to Gln-50, and L0758: 1. Pro-63 to Ala-68, Ala-80 to Asp-93. HEPAE58 509130 2514 174-353 5201 Gly-38 to Asp-56. H0150: 1 and L0743: 1. HEPAE02 921389 2515  3-107 5202 Leu-15 to Lys-24. H0150: 1 and L0522: 1. HEGBC03 922550 2516  2-304 5203 H0550: 1 and L0646: 1. HEGBB67 751233 2517  95-352 5204 Val-6 to Glu-11, H0550: 1 and L0745: Phe-22 to Cys-29. 1. HEGBA01 915596 2518 217-372 5205 H0550: 1 and L0605: 1. HEGAX04 927260 2519  2-230 5206 Lys-18 to Glu-23, H0550: 1 and L0766: Gln-60 to Ala-67. 1. HEGAQ91 789940 2520  2-273 5207 H0550: 1, L0748: 1 Xq22.3 300067, and L0749: 1. 300067, 300121, 300121, 301201, 301835, 311850 HEGAL55 731654 2521 153-359 5208 Lys-5 to Gly-11. H0550: 1, L0745: 1 and L0731: 1. HEGAJ08 959216 2522 344-511 5209 Pro-7 to Val-13. L0731: 2, L0597: 2, H0550: 1, L0783: 1 and L0439: 1. HEGAC02 918992 2523  2-196 5210 Ser-7 to Cys-21, H0550: 1 and L0758: Ile-59 to Gly-64. 1. HEEAY84 782706 2524 222-383 5211 Asn-1 to Lys-14. H0549: 1 and L0748: 1. HEEAX09 912065 2525  2-328 5212 Arg-65 to Arg-72. AR051: 4, AR050: 2, AR054: 2 H0549: 1 HEEAW40 710655 2526 222-398 5213 Asn-45 to Thr-50, H0549: 1, L0589: 1 6q25.2-q27 152200, Pro-52 to Arg-57. and L0366: 1. 167000, 180020, 600320, 600883, 602544 HEEAP59 738892 2527 249-413 5214 Leu-32 to Leu-38. H0549: 1 and L0594: 1. HEEAM25 677599 2528 101-784 5215 L0794: 6, L0806: 2 L0752: 2, H0549: 1, L0796: 1, L0766: 1, L0380: 1, L0803: 1, L0804: 1, L0807: 1, L0789: 1, L0663: 1, L0755: 1, L0596: 1 and L0485: 1. HEEAH94 794257 2529 114-344 5216 H0549: 1 and L0599: 1. HEEAH76 769950 2530  16-213 5217 Val-21 to Gly-26, H0549: 1 and L0748: Leu-29 to Gly-38. 1. HEEAH57 734488 2531 219-404 5218 Pro-3 to Phe-9, H0549: 1 and L0601: Ser-17 to Ala-24, 1. Val-52 to Lys-62. HEEAH16 661827 2532  15-344 5219 Ser-45 to Ser-50, H0549: 1 and L0747: Tyr-103 to Phe-110. 1. HEEAG51 930810 2533  1-423 5220 Glu-61 to Val-77, H0549: 1 and L0605: Phe-81 to Ser-88. 1. HEEAG12 724929 2534 266-36  5221 Thr-29 to Pro-49, AR050: 66, AR054: Asp-65 to Glu-77. 64, AR051: 63, AR089: 13, AR061: 3 H0549: 1 887048 2694 429-295 5381 HEEAD13 470886 2535  1-195 5222 H0549: 1 and L0756: 1. HEEAB40 710668 2536 128-310 5223 Val-15 to Ala-23, H0549: 1 and L0748: Pro-30 to Ser-35. 1. HEAAX26 684734 2537  63-182 5224 Val-22 to Gly-29. H0369: 1 and L0740: 1. HEAAU20 911255 2538  65-364 5225 Lys-80 to Lys-86. H0369: 1 and L0745: 6q21 120110, 1. 1 121014, 601666, 602772 HEAAR47 973284 2539  20-220 5226 H0369: 1 HEAAR21 883939 2540 353-535 5227 Gly-1 to Ser-6. H0369: 1 and L0769: 1. HEAAN43 842032 2541 235-336 5228 H0369: 1 and L0748: 1. HEAAM71 950736 2542 321-563 5229 Thr-3 to Ala-10, L0539: 1, H0369: 1 Glu-30 to Arg-38. and L0748: 1. HEAAL76 770200 2543  2-136 5230 Leu-23 to His-28. H0369: 1 and L0589: 1. HEAAG84 896892 2544 605-396 5231 H0369: 1 904209 2695 1539-1913 5382 Arg-43 to Ser-49, Glu-55 to Ser-61, Pro-70 to Arg-75, Cys-91 to Gly-103. 906483 2696 316-504 5383 Arg-45 to Gly-52. HEAAG42 714041 2545 598-792 5232 Glu-24 to Tyr-31. L0731: 9, L0754: 3 and H0369: 1. HEAAB66 844361 2546 438-740 5233 H0369: 1 HCORB05 928679 2547  2-142 5234 Pro-1 to Arg-14. L0626: 1, L0775: 1, L0776: 1 and H0670: 1. HCOPM06 933473 2548 158-628 5235 Pro-15 to Glu-21, L0769: 1, L0665: 1 and Ala-43 to Glu-58, H0670: 1. Leu-96 to Glu-101, Ala-111 to Ala-119. HCOPI07 951645 2549 185-313 5236 Thr-29 to Arg-43. H0670: 1 and L0758: 1. HCOPF07 951655 2550  79-240 5237 L0799: 3, L0758: 3 and H0670: 1. HCOOF07 951693 2551 221-493 5238 Pro-13 to Ser-19, H0670: 1, L0731: 1 Asp-27 to Thr-35. and L0759: 1. HCONP02 917577 2552 148-306 5239 Asn-7 to Val-13. L0517: 1, L0438: 1, H0670: 1 and L0439: 1. HCONM33 971637 2553 474-217 5240 Asp-5 to Ala-11, L0517: 2, L0756: 2, Trp-24 to Phe-31, L0803: 1, L0776: 1, Arg-44 to Trp-50. L0809: 1, L0663: 1, H0670: 1, L0755: 1 and L0759: 1. HCOMM05 925952 2554  1-840 5241 Gln-19 to Asp-38, AR089: 1, AR061: 1 Pro-46 to Thr-55, H0670: 1 Leu-96 to Gly-104, Ala-114 to Ala-119, Gln-125 to Trp-131, Pro-133 to Pro-141, Phe-144 to Glu-150, Glu-180 to Val-185, Glu-192 to Glu-197, Glu-254 to Leu-262, Met-272 to Ser-280. HCHQA48 908495 2555  13-357 5242 Cys-6 to Lys-21, H0484: 1 and L0743: Ser-53 to Ile-65, 1. Asn-68 to Gln-80, Arg-106 to Ala-114. HCHOX63 957690 2556  1-741 5243 Arg-1 to Lys-12, H0484: 1, L0617: 1, Gly-57 to Gly-62, L0772: 1, L0751: 1 and Pro-74 to Asp-80. L0752: 1. HCHNW48 862478 2557 122-325 5244 Lys-1 to Ser-13. AR061: 1, AR089: 1 H0484: 1 and L0589: 1. HCHMX82 850340 2558  2-349 5245 H0484: 1 and L0749: 1. HCHMW18 966985 2559  97-408 5246 Leu-8 to Val-20, L0757: 2 and H0484: Arg-25 to Arg-35, 1. Ala-38 to Trp-46, Phe-69 to Tyr-75, Ser-96 to Trp-104. HCHMJ89 786765 2560  2-218 5247 Ala-1 to Gly-8, H0484: 1 and L0439: Arg-16 to Ser-21, 1. Ser-35 to Pro-45, Ala-61 to Gly-67. HCHMI96 800129 2561  3-248 5248 AR051: 32, AR054: 29, AR050: 28 H0484: 1 HCHMI15 935298 2562  52-591 5249 Lys-67 to Ser-79, H0484: 1 and L0792: Ser-89 to Thr-109, 1. Asn-116 to Ser-129, Glu-140 to Lys-147, Ser-161 to Lys-172. HCHCI07 952957 2563 248-499 5250 Gly-1 to Trp-6, L0749: 3 and H0483: Gly-74 to Trp-80. 1. HCHCH68 869084 2564 251-502 5251 H0483: 1 and L0764: 1. HCHCG28 686431 2565 214-462 5252 Phe-32 to Ala-37. L0748: 3, L0596: 2, H0483: 1, L0439: 1 and L0749: 1. HCHCE78 773428 2566  11-193 5253 H0483: 1 HCHBQ27 682308 2567  11-241 5254 Gly-4 to Lys-10, H0483: 1 Gln-36 to Glu-41, Arg-61 to Arg-76. HCHBN09 625420 2568  1-177 5255 Gly-1 to Ser-13. H0483: 1 19q13.2 107741, 113900, 122720, 122720, 126340, 126391, 160900, 164731, 173850, 207750, 248600, 258501 HCHBM26 681404 2569  13-153 5256 Gly-4 to Lys-10, H0483: 1 Gln-36 to Glu-41. HCHAI62 743411 2570  2-148 5257 Lys-1 to Lys-21. H0483: 1 HCHAH04 487985 2571  1-75 5258 H0483: 1 HCHAG52 726081 2572  3-212 5259 Ser-26 to Thr-44. H0483: 1 HCDMF96 796196 2573  86-286 5260 Gly-12 to Cys-27. L0752: 1 and S0398: 1. HCDME32 863374 2574 147-473 5261 Glu-8 to Met-22, L0777: 1, L0758: 1, Pro-104 to Pro-109. L0697: 1 and S0398: 1. HCDMC86 785134 2575 160-330 5262 Glu-12 to Leu-20. S0398: 1 HCDMC25 677627 2576  47-283 5263 Gln-9 to Val-17, L0439: 1 and S0398: 1. Phe-38 to Glu-45. HCDMC23 675490 2577 116-271 5264 S0398: 1 HCDMC22 672815 2578  2-241 5265 S0398: 1 HCDMC06 934663 2579  28-183 5266 S0398: 1 HCDMB91 789551 2580 185-289 5267 S0398: 1 HCDMB42 713300 2581 128-244 5268 Gly-12 to His-19. S0398: 1 HCDMB41 711996 2582  2-202 5269 Gly-13 to Asn-22. L0587: 1 and S0398: 1. HCDMB27 682389 2583  23-148 5270 S0398: 1 HCDMB12 968918 2584 418-627 5271 Pro-7 to Gly-24. AR050: 93, AR054: 62, AR051: 57 S0398: 1 HCDMB08 958542 2585 115-267 5272 Gly-38 to Gly-51. L0753: 1 and S0398: 1. HCDMB03 923316 2586  88-252 5273 Cys-20 to His-27, S0398: 1 Glu-35 to Lys-54. HCDMA20 669201 2587  3-92 5274 L0438: 1, L0439: 1 and S0398: 1. HCBND03 922388 2588  3-401 5275 Pro-12 to Thr-21, H0661: 1, L0805: 1 Gly-35 to Thr-41, and L0776: 1 Thr-53 to Gln-75, Ser-92 to Gly-98. HCBMZ07 951788 2589 230-358 5276 H0661: 1 and L0740: 1. HCBMY10 961718 2590 371-138 5277 Glu-22 to Glu-49. H0661: 1 and L0603: 1. HCBMG11 965394 2591 207-653 5278 Ala-1 to Asn-9, H0661: 1, L0664: 1, Thr-24 to Asn-29, L0754: 1 and L0749: 1. Gly-43 to Arg-53, Arg-106 to Arg-111. HBZSK04 926407 2592  2-79 5279 Gln-7 to Lys-14. S0190: 1 HBZSG02 920249 2593  40-291 5280 L0771: 2 and S0190: 1. HBZSD32 699335  59-427 5281 Val-8 to Leu-14, S0190: 1 Pro-22 to Arg-31, Thr-62 to Lys-68, Arg-76 to Cys-82, Trp-85 to His-91. HBZAJ73 764479 2595  2-244 5282 L0741: 3 and S0188: 1. HBZAJ26 681879 2596 198-443 5283 Gly-38 to Ser-44. S0188: 1 and L0747: 1. HBZAI39 847621 2597 545-808 5284 S0188: 1 and L0605: 1. HBZAI14 847620 2598  2-203 5285 S0188: 1 HBZAB15 660348 2599 240-362 5286 Lys-26 to His-31. S0188: 1 and L0587: 1. HBZAB08 959560 2600 160-414 5287 Pro-1 to Gln-15, L0774: 3, L0775: 1, Gln-38 to Asn-45, L0809: 1, S0188: 1 and Pro-57 to Thr-65. L0758: 1. HBNBQ50 887096 2601 222-473 5288 Arg-54 to Arg-60. H0188: 1 and L0751: 1. HBNBO30 430360 2602  3-155 5289 Glu-17 to Tyr-22. L0774: 2, L0741: 2 L0439: 2, L0411: 1 and H0188: 1. HBNBL29 703113 2603 245-409 5290 H0188: 1, L0663: 1 and L0748: 1. HBNBJ29 907015 2604  63-215 5291 Trp-18 to Gly-23, H0188: 1 and L0526: Ser-25 to Met-31. 1. HBNBJ06 960664 2605  2-298 5292 H0188: 1, L0769: 1 and L0753: 1. HBNBB41 712676 2606  50-256 5293 H0188: 1 and L0748: 1. HBNBB27 600905 2607 143-3  5294 H0188: 1 847732 2697  1-186 5384 HBNBB09 868924 2608 372-79  5295 L0439: 3 and H0188: 1. HBNAW73 764716 2609  87-236 5296 H0188: 1 and L0748: 1. HBNAC74 586797 2610  3-152 5297 Asp-30 to Trp-36, H0188: 1 Ser-39 to Trp-44. HBNAC71 525831 2611  2-318 5298 Arg-10 to Glu-32. H0188: 1 HBNAC48 721983 2612 150-308 5299 H0188: 1 HBNAC42 714263 2613  2-120 5300 H0188: 1 and L0591: 1. HBNAC32 526549 2614  1-111 5301 H0188: 1 HBNAC28 525832 2615  34-183 5302 H0188: 1 HBNAC25 525834 2616  3-146 5303 Leu-2 to Gln-11, H0188: 1 Lys-35 to Lys-48. HBNAC09 525833 2617  8-76 5304 H0188: 1 HBNAC02 921187 2618  2-199 5305 Pro-24 to Ala-37. H0188: 1 HBGTT76 903653 2619  14-556 5306 His-8 to Gly-18, AR050: 173, AR051: Pro-89 to Gly-96, 169, AR054: 143, Lys-126 to Trp-131, AR089: 46, AR061: 9 Glu-133 to Gly-141. H0617: 1 HBGTE11 965121 2620  71-325 5307 Gly-14 to Val-21. H0617: 1, L0766: 1 and L0788: 1. HBGQS88 886650 2621  2-448 5308 Pro-16 to Gly-38, AR054: 7, AR051: 2 Arg-50 to Arg-58, AR050: 1 Asp-65 to Asn-81. H0617: 1, L0769: 1, L0637: 1 and L0789: 1. HBGNL85 848179 2622  1-570 5309 Thr-10 to Gly-16. H0617: 1, L0767: 1, L0775: 1 and L0779: 1. HBGND04 926973 2623  55-354 5310 Ser-73 to Lys-78, L0779: 2, L0752: 2, Pro-93 to Gly-100. H0617: 1 and L0794: 1. HBGMT82 954374 2624  28-507 5311 H0617: 1, L0774: 1, L0747: 1 and L0752L 1. HBGMS69 754392 2625  3-272 5312 Pro-46 to Gly-55, H0617: 1 and L0750: Arg-79 to Cys-89. 1. HBGMO78 773043 2626 104-307 5313 Ser-28 to Trp-36. L0758: 2 and H0617: 1. HBGMG81 880276 2627  37-363 5314 Lys-3 to Leu-13, AR050: 297, AR051: Pro-70 to Ser-78. 237, AR054: 211 H0617: 1 HBGFS88 914032 2628 358-140 5315 L0748: 2, H0606: 1 and L0593: 1. HBGFG53 727748 2629 267-473 5316 Gly-18 to Gly-24, H0606: 1 and L0777: Gly-31 to Ser-38, 1. His-57 to Asn-62. HBGDH33 702854 2630  2-374 5317 L0439: 6, L0776: 2, L0777: 2, H0181: 1, L0762: 1 and L0809: 1. HBGDF39 861602 2631  2-355 5318 Leu-92 to Phe-98. AR089: 0, AR061: 0 H0181: 1 HBGDA74 832888 2632  2-277 5319 AR089: 33, AR061: 29 11q13 102200, H0181: 1 106100, 131100, 131100, 131100, 133780, 147050, 153700, 161015, 164009, 168461, 168461, 168461, 180721, 180840, 191181, 193235, 209901, 232600, 259700, 259770, 600045, 600319, 600528, 601884 HBGBG69 802090 2633  1-57 5320 Lys-8 to Ala-14. H0181: 1 HBGBG67 588263 2634  2-157 5321 H0181: 1 HBGBG52 522424 2635 120-257 5322 Leu-8 to Gly-19, H0181: 1 Leu-31 to Cys-36. HBGBG38 525837 2636  2-150 5323 Ser-1 to Glu-10. H0181: 1 HBGBE12 971466 2637  1-69 5324 H0181: 1 HBGBB78 773930 2638  2-342 5325 Ser-11 to Trp-17, H0181: 1 and L0741: Pro-19 to Thr-28. 1. HBCPV80 932817 2639  2-403 5326 Arg-1 to Arg-8, AR061: 1, AR089: 1 Glu-29 to Arg-37. H0663: 1 and L0783: 1. HBCPO75 927520 2640 135-356 5327 Ala-26 to Val-32. L0779: 3, H0663: 1, L0757: 1 and L0758: 1. HBCPK03 922493 2641 194-514 5328 Lys-25 to Asn-34, H0663: 1 and L0766: Thr-92 to Gly-98. 1. HBCJP02 917981 2642 349-507 5329 Glu-14 to Ala-30, H0664: 1 and L0758: Ile-46 to Lys-53. 1. HBCJG07 951898 2643  2-137 5330 Arg-5 to Ser-15. L0754: 2, H0664: 1 and L0748: 1. HAUCC58 764851 2644  31-402 5331 Cys-1 to Arg-15, H0294: 1 and L0777: Lys-28 to Asp-36, 1. Thr-64 to Leu-74, Cys-99 to Arg-107, Lys-117 to Arg-124. HAUAW51 577959 2645 119-349 5332 Ser-24 to Trp-30, H0294: 1 and L0748: Glu-38 to Arg-50. 1. HAUAS89 518847 2646  25-132 5333 H0294: 1 HAUAQ28 685374 2647 320-427 5334 H0294: 1 and L0608: 1. HAQCF25 678235 2648  2-303 5335 L0794: 2, L0599: 2, H0295: 1, L0763: 1, L0800: 1 and L0515: 1. HAQCD07 958959 2649 198-425 5336 Arg-25 to Ser-50. H0295: 1 and L0780: 1. HACMR08 955638 2650  2-280 5337 Leu-30 to Lys-38, L0809: 2, H0685: 1, Trp-49 to Ala-58, L0776: 1 and L0780: 1. Gly-75 to Pro-80.

[0079] The first column in Table 1A provides a unique “Clone ID NO: Z” for a cDNA clone related to each contig sequence disclosed in Table 1A. This clone ID references the cDNA clone which contains at least the 5′ most sequence of the assembled contig and at least a portion of SEQ ID NO: X was determined by directly sequencing the referenced clone. The reference clone may have more sequence than described in the sequence listing or the clone may have less. In the vast majority of cases, however, the clone is believed to encode a full-length polypeptide. In the case where a clone is not full-length, a full-length cDNA can be obtained by methods known in the art and/or as described elsewhere herein.

[0080] The second column in Table 1A provides a unique “Contig ID” identification for each contig sequence. The third column provides the “SEQ ID NO: X” identifier for each of the reproductive system associated contig polynucleotide sequences disclosed in Table 1A. The fourth column, “ORF (From-To)”, provides the location (i.e., nucleotide position numbers) within the polynucleotide sequence “SEQ ID NO: X” that delineate the preferred open reading frame (ORF) shown in the sequence listing and referenced in Table 1A, column 5, as SEQ ID NO: Y. Where the nucleotide position number “To” is lower than the nucleotide position number “From”, the preferred ORF is the reverse complement of the referenced polynucleotide sequence.

[0081] The fifth column in Table 1A provides the corresponding SEQ ID NO: Y for the polypeptide sequence encoded by the preferred ORF delineated in column 4. In one embodiment, the invention provides an amino acid sequence comprising, or alternatively consisting of, a polypeptide encoded by the portion of SEQ ID NO: X delineated by “ORF (From-To)”. Also provided are polynucleotides encoding such amino acid sequences and the complementary strand thereto.

[0082] Column 6 in Table 1A lists residues comprising epitopes contained in the polypeptides encoded by the preferred ORF (SEQ ID NO: Y), as predicted using the algorithm of Jameson and Wolf, (1988) Comp. Appl. Biosci. 4:181-186. The Jameson-Wolf antigenic analysis was performed using the computer program PROTEAN (Version 3.11 for the Power MacIntosh, DNASTAR, Inc., 1228 South Park Street Madison, Wis.). In some embodiments, polypeptides of the invention comprise, or alternatively consist of, at least one, two, three, four, five or more of the predicted epitopes as described in Table 1A. It will be appreciated that depending on the analytical criteria used to predict antigenic determinants, the exact address of the determinant may vary slightly.

[0083] Column 7 in Table 1A provides an expression profile and library code: count for each of the contig sequences (SEQ ID NO: X) disclosed in Table 1A, which can routinely be combined with the information provided in Table 4 and used to determine the normal or diseased tissues, cells, and/or cell line libraries which predominantly express the polynucleotides of the invention. The first number in column 7 (preceding the colon), represents the tissue/cell source identifier code corresponding to the code and description provided in Table 4. For those identifier codes in which the first two letters are not “AR”, the second number in column 7 (following the colon) represents the number of times a sequence corresponding to the reference polynucleotide sequence was identified in the tissue/cell source. Those tissue/cell source identifier codes in which the first two letters are “AR” designate information generated using DNA array technology. Utilizing this technology, cDNAs were amplified by PCR and then transferred, in duplicate, onto the array. Gene expression was assayed through hybridization of first strand cDNA probes to the DNA array. cDNA probes were generated from total RNA extracted from a variety of different tissues and cell lines. Probe synthesis was performed in the presence of ³³P dCTP, using oligo(dT) to prime reverse transcription. After hybridization, high stringency washing conditions were employed to remove non-specific hybrids from the array. The remaining signal, emanating from each gene target, was measured using a Phosphorimager. Gene expression was reported as Phosphor Stimulating Luminescence (PSL) which reflects the level of phosphor signal generated from the probe hybridized to each of the gene targets represented on the array. A local background signal subtraction was performed before the total signal generated from each array was used to normalize gene expression between the different hybridizations. The value presented after “[array code]:” represents the mean of the duplicate values, following background subtraction and probe normalization. One of skill in the art could routinely use this information to identify normal and/or diseased tissue(s) which show a predominant expression pattern of the corresponding polynucleotide of the invention or to identify polynucleotides which show predominant and/or specific tissue and/or cell expression. The sequences disclosed herein have been determined to be predominantly expressed in reproductive system tissues, including normal and diseased reproductive system tissues (See Table 1A, column 7 and Table 4).

[0084] Column 8 in Table 1A provides a chromosomal map location for certain polynucleotides of the invention. Chromosomal location was determined by finding exact matches to EST and cDNA sequences contained in the NCBI (National Center for Biotechnology Information) UniGene database. Each sequence in the UniGene database is assigned to a “cluster”; all of the ESTs, cDNAs, and STSs in a cluster are believed to be derived from a single gene. Chromosomal mapping data is often available for one or more sequence(s) in a UniGene cluster; this data (if consistent) is then applied to the cluster as a whole. Thus, it is possible to infer the chromosomal location of a new polynucleotide sequence by determining its identity with a mapped UniGene cluster.

[0085] A modified version of the computer program BLASTN (Altshul et al., J. Mol. Biol. 215:403-410 (1990), and Gish et al., Nat. Genet. 3:266-272 (1993)) was used to search the UniGene database for EST or cDNA sequences that contain exact or near-exact matches to a polynucleotide sequence of the invention (the ‘Query’). A sequence from the UniGene database (the ‘Subject’) was said to be an exact match if it contained a segment of 50 nucleotides in length such that 48 of those nucleotides were in the same order as found in the Query sequence. If all of the matches that met this criteria were in the same UniGene cluster, and mapping data was available for this cluster, it is indicated in Table 1A under the heading “Cytologic Band”. Where a cluster had been further localized to a distinct cytologic band, that band is disclosed; where no banding information was available, but the gene had been localized to a single chromosome, the chromosome is disclosed.

[0086] Once a presumptive chromosomal location was determined for a polynucleotide of the invention, an associated disease locus was identified by comparison with a database of diseases which have been experimentally associated with genetic loci. The database used was the Morbid Map, derived from OMIM™ (supra). If the putative chromosomal location of a polynucleotide of the invention (Query sequence) was associated with a disease in the Morbid Map database, an OMIM reference identification number was noted in column 9, Table 1A, labeled “OMIM Disease Reference(s)”. Table 5 is a key to the OMIM reference identification numbers (column 1), and provides a description of the associated disease in Column 2. TABLE 1B Clone ID SEQ ID CONTIG SEQ ID EXON NO:Z NO:X ID: BAC ID: A NO:B From-To HAOSH55 14 952380 AL353194 5385  1-964 1250-1399 2650-2905 3588-3668 3971-4987 5854-5963 7336-7775 7870-8256 8419-8895 9000-9339 HAOSH55 14 952380 AL353194 5386  1-90 HAQAK73 15 764671 AC023906 5387  1-739 HAQAK73 15 764671 AC023906 5388  1-845 HAQBS37 20 847519 AP002519 5389  1-168 683-777 1538-3043 3578-4180 5564-5793 6266-6409 6412-6738 7035-7451 HAUBD69 21 529711 AL359674 5390  1-138 HAUBD69 21 529711 AL359674 5391  1-380 HAUBU10 22 968339 AC027538 5392  1-463 HAUBU10 22 968339 AC010770 5393  1-463 HAUBU10 22 968339 AC027538 5394  1-288 HAUBU10 22 968339 AC010770 5395  1-288 HBCQS93 27 930682 AL109945 5396  1-310 1220-1839 HBCQS93 27 930682 AC022307 5397  1-310 1220-1839 2206-2683 2691-2788 3337-3381 HBCQS93 27 930682 AL109945 5398  1-131 HBGBF56 29 957870 AL031963 5399  1-249 HBGBF56 29 957870 AL133351 5400  1-249 HBGBF56 29 957870 AL031963 5401  1-249 HBGBF56 29 957870 AL031963 5402  1-429 HBGBF56 29 957870 AL133351 5403  1-580 1364-1792 2134-2229 3072-3565 3973-4080 HBGBF56 29 957870 AL031963 5404  1-349 HBGBF56 29 957870 AL133351 5405  1-349 HBGBF56 29 957870 AL031963 5406  1-349 HBGBG42 30 922396 AL096773 5407  1-518 1341-1514 3365-3956 4169-4282 4430-4892 6254-7763 HBGBG42 30 922396 AL096773 5408  1-114 HBGBG42 30 922396 AL096773 5409   1-3033 HBGBH43 31 524532 AP000757 5410  1-726 HBGBH43 31 524532 AP000683 5411  1-726 HBGBH43 31 524532 AP000757 5412  1-249 299-451 651-926 HBGBH43 31 524532 AP000683 5413  1-249 299-452 651-926 HBGBS07 32 954299 AL358472 5414  1-93 229-341 458-525 639-725  820-2416 3085-3172 3955-5506 5626-6422 HBGBS07 32 954299 AL358472 5415  1-391 HBGBS07 32 954299 AL358472 5416  1-344 399-469 HBGBW60 34 954916 AC007779 5417  1-542 1709-1905 3246-3805 HBGBW60 34 954916 AC015667 5418  1-542 1705-1901 3242-3801 HBGBW60 34 954916 AC007936 5419  1-545 1736-1917 3269-3833 6267-6287 HBGBW72 35 524956 AL139376 5420  1-448 HBGBW72 35 524956 AL139376 5421  1-526 HBGDE85 37 524875 AC020850 5422  1-912 1276-1413 HBGDE85 37 524875 AC008693 5423  1-138 HBGDE85 37 524875 AC023611 5424  1-105 HBGDE85 37 524875 AC022123 5425  1-957 1332-1469 HBGDE85 37 524875 AC010845 5426  1-138 HBGDT43 39 974223 L81574 5427  1-168 HBGDT43 39 974223 AC022276 5428  1-166 HBGDT43 39 974223 AC023653 5429  1-57 HBGDT43 39 974223 AC012102 5430  1-140 HBGDT43 39 974223 AC048382 5431  1-115 HBGDT43 39 974223 AC011036 5432  1-193 HBGDT43 39 974223 AC068682 5433  1-153 HBGDT43 39 974223 AL356496 5434  1-35 HBGDT43 39 974223 AC006087 5435  1-129 HBGDT43 39 974223 AC016142 5436  1-150 HBGDT43 39 974223 AC027456 5437  1-98 HBGDT43 39 974223 AC016797 5438  1-116 HBGDT43 39 974223 AL356606 5439  1-87 HBGDT43 39 974223 AC025181 5440  1-159 HBGDT43 39 974223 AC055788 5441  1-170 HBGDT43 39 974223 AC027264 5442  1-147 HBGDT43 39 974223 AC026537 5443  1-132 HBGDT43 39 974223 AC000360 5444  1-142 HBGDT43 39 974223 AC023583 5445  1-153 HBGDT43 39 974223 AL161613 5446  1-63 HBGDT43 39 974223 AC062010 5447  1-155 HBGDT43 39 974223 AC004803 5448  1-154 HBGDT43 39 974223 AC023583 5449  1-59 1391-1548 HBGDT43 39 974223 AL161613 5450  1-129 HBGDT43 39 974223 L81574 5451  1-315 1979-2215 2720-3771 HBGDT43 39 974223 AL356496 5452  1-131 HBGFA62 40 954306 AC016889 5453  1-700 855-956  962-1444 1446-2545 2846-3201 3316-3569 4130-4421 4424-4461 HBGFA62 40 954306 AC016889 5454  1-35 309-427 1161-1286 3151-3255 3263-3604 4836-5346 5473-5765 6231-6283 6387-6534 HBGMD62 42 933763 AL031258 5455  1-692  707-1312 HBGMD62 42 933763 AC068332 5456  1-671 HBGMD62 42 933763 AL031258 5457  1-349 438-545 675-725 744-903 1124-1593 1726-1832 1904-1966 2656-2704 HBGMF10 43 966132 AC068259 5458  1-743  914-1113 1118-1586 HBGMF10 43 966132 AC068259 5459  1-466 HBGMF10 43 966132 AC068259 5460  1-279 HBGMZ39 45 947112 AC008537 5461   1-1186 HBGMZ39 45 947112 AC019337 5462   1-1182 HBGMZ39 45 947112 AC008537 5463   1-1993 2105-2385 2736-3068 4364-4489 6546-6781 7025-8165 HBGMZ39 45 947112 AC019337 5464   1-1991 2103-2383 2734-3066 4360-4485 6541-6776 7021-8159 HBGMZ39 45 947112 AC008537 5465  1-734  767-1001 HBGMZ39 45 947112 AC019337 5466  1-158 291-565 598-832 HBGND09 47 848219 AL139288 5467   1-1670 HBGND09 47 848219 AC023889 5468   1-1670 HBGND09 47 848219 AC026657 5469   1-1477 HBGND09 47 848219 AC023889 5470  1-440 HBGND09 47 848219 AL139288 5471  1-397 HBGND09 47 848219 AC026657 5472  1-396 HBGND09 47 848219 AC023889 5473  1-396 HBGNJ14 48 914594 AC004156 5474  1-56  391-1058 1079-1478 1996-2053 2539-2612 2844-3219 3313-3602 3796-3919 4012-4767 HBGNJ14 48 914594 AC004156 5475  1-275 HBGNO07 50 952212 AC073131 5476   1-1122 HBGNO07 50 952212 AC008403 5477   1-1630 2058-2480 4161-4577 5334-5745 6732-6865 7024-7163 10746-11227 11908-12229 12481-13862 HBGNO07 50 952212 AC008403 5478  1-482 2074-2191 3067-3427 3514-3666 4176-4250 4718-4839 5313-5692 10395-10491 10694-10779 11107-11256 12127-12209 12283-12405 12543-13031 13771-14040 HBGNO07 50 952212 AC008403 5479  1-128 172-232 1302-2232 HBGNQ31 51 887152 AL118522 5480  1-258 787-912 2028-2776 3673-3948 4188-4463 HBGNQ31 51 887152 AL118522 5481   1-1160 HBGNW29 52 969396 AL139288 5482   1-1670 HBGNW29 52 969396 AC023889 5483   1-1670 HBGNW29 52 969396 AC026657 5484   1-1477 HBGNW29 52 969396 AC023889 5485  1-440 HBGNW29 52 969396 AL139288 5486  1-397 HBGNW29 52 969396 AC026657 5487  1-396 HBGNW29 52 969396 AC023889 5488  1-396 HBGOB07 53 883111 AC008655 5489  1-895 HBGOB07 53 883111 AC008655 5490   1-1013 HBGOB07 53 883111 AC008655 5491  1-909 1371-1545 3390-3501 4360-4549 5287-5337 5422-5540 7645-7790 8678-8898  9930-10085 HBGPH02 58 918513 AC003037 5492  1-492 HBGPH02 58 918513 AC003037 5493  1-86 3463-3839 4494-4881 4901-6058 HBGPH02 58 918513 AC003037 5494   1-2178 2394-3039 3041-3358 4072-4175 4212-4316 4571-4941 5381-5529 5783-5886 6445-6588 8722-8835 HBGPK33 59 973425 AC012305 5495  1-712 HBGPK33 59 973425 AC067853 5496  1-712 HBGPK33 59 973425 AC067853 5497  1-601 HBGPV05 60 930706 AC020866 5498  1-592 HBGSD40 62 923142 AC007783 5499  1-215  697-1759 HBGSD40 62 923142 AC022007 5500  1-555 HBGSD40 62 923142 AC018809 5501  1-867 HBGSD40 62 923142 AC007783 5502  1-534 HBGSD40 62 923142 AC007783 5503  1-314 814-969 1228-1301 1391-1502 2374-2548 2750-3470 HBGSD40 62 923142 AC022007 5504  1-279 HBGSD40 62 923142 AC022007 5505  1-314 814-969 1228-1301 1391-1502 2374-2548 2750-3492 3815-3858 4506-4812 5780-6087 6765-6905 7117-7178 11051-11101 11244-11380 11469-11524 12621-12789 12919-13141 13291-13351 13474-13835 14502-14734 14773-15067 15215-16491 HBGSD40 62 923142 AC018809 5506  1-314 814-969 1228-1301 1391-1502 2375-2549 2751-3431 HBGTL01 64 914573 Z97986 5507  1-696 3066-3591 HBGTL01 64 914573 Z97986 5508  1-334 HBNAN41 69 655842 AC005729 5509  1-307 HBNAN41 69 655842 AC005729 5510  1-116 HBNAN41 69 655842 AC005729 5511  1-177 HBNAX71 71 530843 AL157375 5512  1-87 HBNAX71 71 530843 AL157375 5513  1-430 HBNAY58 72 558193 AC046185 5514  1-836 HBNBT52 73 524869 AC069303 5515  1-488 HBNBT52 73 524869 AC069303 5516  1-205 H3NBT52 73 524869 AC069303 5517  1-315 HBZAJ09 74 655769 AC019232 5518  1-315 HBZAJ09 74 655769 AC025171 5519  1-315 HBZAJ09 74 655769 AC019232 5520  1-324 HBZAJ09 74 655769 AC025171 5521  1-148 HBZAJ09 74 655769 AC019232 5522  1-148 HBZAJ09 74 655769 AC025171 5523  1-283 HBZSH16 75 655619 AC069483 5524  1-554 HBZSH16 75 655619 AC069483 5525  1-920 HBZSH71 76 760418 AC018693 5526  1-741 HBZSH71 76 760418 AC018693 5527  1-252 HBZSI73 77 655737 AC067954 5528  1-313 HBZSI73 77 655737 AC067954 5529  1-326 HBZSK17 78 664013 AC005005 5530  1-139 521-674 838-1409 1438-1598 1860-1995 6648-6796 7196-7292 7385-7460 7554-7650 8380-8713 8789-8863 9491-9560 9642-9826 10042-10528 11147-11210 13983-15090 15211-15587 15681-16021 17348-17536 17744-17862 17957-18234 18373-18580 19081-19435 19568-19733 19815-19932 20132-20466 22166-22791 22824-23307 HBZSK17 78 664013 AC005005 5531   1-1393 2604-2971 HCBMV01 79 914333 AP002479 5532  1-401 HCBMV01 79 914333 AC012569 5533  1-193 379-463 1042-1115 2571-3004 3344-3468 4339-4433 5418-5606 5875-6012 6119-6519 7622-7713 HCBMV01 79 914333 AP001895 5534  1-74 1527-1591 1656-1960 2300-2424 3295-3389 4374-4562 4831-4968 5075-5475 6579-6670 HCBMV01 79 914333 AP002479 5535  1-189 HCBMV01 79 914333 AC012569 5536  1-87 HCBMV01 79 914333 AP001895 5537  1-87 HCBMV01 79 914333 AP001895 5538  1-108 HCBNW02 80 950897 AF205589 5539  1-32 110-254 333-849 918-999 1069-1147 1231-1322 1435-1687 1765-1881 1958-2357 2441-3044 3104-3153 3226-3549 3626-3791 3874-4018 4089-4184 4258-4377 4424-5493 5591-5736 5834-5922 6196-6415 6479-6654 6735-6895 7030-7124 7229-7371 7452-7567 7707-7796 7887-7969 8059-8133 8149-8306 8381-8736 HCDMB01 83 915613 AC012484 5540  1-355 HCDMC01 86 915239 AC005789 5541  1-48 1051-2390 2839-3458 HCDMC01 86 915239 AC005789 5542   1-1721 2187-3101 3194-3363 4200-4903 5310-5493 6194-6294 7366-7482 7598-7676 8092-8778 8869-9496 HCDMD23 87 676799 AC018743 5543  1-801 HCDMD23 87 676799 AC018630 5544  1-413 HCDMD23 87 676799 AC018743 5545  1-138 HCDMD23 87 676799 AC018630 5546  1-177 HCHAD40 88 923764 AC006096 5547  1-240  737-1362 HCHAD40 88 923764 AC006106 5548  1-240  736-1423 HCHAD40 88 923764 AC006108 5549  1-240  736-1359 HCHAD40 88 923764 AC006179 5550  1-230 1021-1223 HCHAD40 88 923764 U82205 5551  1-255 736-849 1023-1457 HCHAD40 88 923764 U82208 5552  1-240  736-1425 HCHAD40 88 923764 AC006186 5553   1-2213 2217-2456 2952-4550 4562-4643 4906-5701 HCHAD40 88 923764 AC006171 5554  1-240  736-1540 7244-8075 8087-8167 HCHAD40 88 923764 AC006177 5555   1-2212 2216-2455 2951-4547 4559-4639 4902-5697 HCHAD40 88 923764 AC006180 5556  1-240  736-1625 HCHAD40 88 923764 U82210 5557   1-2210 2214-2453 2949-4547 4559-4614 4899-5620 HCHAD40 88 923764 AC006185 5558  1-240  736-1359 HCHAD40 88 923764 AC006184 5559   1-2204 2208-2447 2943-3574 3724-4540 4552-4633 4896-5715 HCHAD40 88 923764 AC006172 5560  1-240  847-1425 HCHAD40 88 923764 AC006099 5561  1-240  736-1424 HCHAD40 88 923764 AC006103 5562  1-240  737-2325 HCHAD40 88 923764 AC006098 5563  1-240  736-1424 HCHAD40 88 923764 AC006096 5564   1-2211 HCHAD40 88 923764 AC006106 5565   1-2215 HCHAD40 88 923764 AC006108 5566   1-2210 HCHAD40 88 923764 AC006179 5567  1-358 HCHAD40 88 923764 U82205 5568   1-2213 HCHAD40 88 923764 U82208 5569   1-2212 HCHAD40 88 923764 AC006171 5570   1-2213 HCHAD40 88 923764 AC006177 5571  1-67 1558-1614 1692-2134 2610-2767 4075-4344 5072-5484 5971-6837 7042-7752 HCHAD40 88 923764 AC006180 5572   1-2213 HCHAD40 88 923764 AC006171 5573  1-794 HCHAD40 88 923764 AC006185 5574   1-2206 HCHAD40 88 923764 AC006184 5575  1-130 HCHAD40 88 923764 AC006172 5576   1-2211 HCHAD40 88 923764 AC006099 5577   1-2212 HCHAD40 88 923764 AC006103 5578   1-2213 HCHAD40 88 923764 AC006098 5579   1-2212 HCHAR16 89 675465 AC068327 5580  1-402  667-3113 HCHAR43 90 715128 AC003036 5581  1-444 4270-4530 7834-7966 8367-8509 9404-9466 9576-9674 HCHAR43 90 715128 AC003036 5582  1-550 HCHBQ03 92 923763 AC006106 5583  1-240  736-1423 HCHBQ03 92 923763 U82205 5584  1-255 736-849 1023-1457 HCHBQ03 92 923763 U82208 5585  1-240  736-1425 HCHBQ03 92 923763 AC006186 5586   1-2213 2217-2456 2952-4550 4562-4643 4906-5701 HCHBQ03 92 923763 AC006171 5587  1-240  736-1540 7244-8075 8087-8167 HCHBQ03 92 923763 AC006177 5588   1-2212 2216-2455 2951-4547 4559-4639 4902-5697 HCHBQ03 92 923763 AC006180 5589  1-240  736-1625 HCHBQ03 92 923763 U82210 5590   1-2210 2214-2453 2949-4547 4559-4614 4899-5620 HCHBQ03 92 923763 AC006185 5591  1-240  736-1359 HCHBQ03 92 923763 AC006184 5592   1-2204 2208-2447 2943-3574 3724-4540 4552-4633 4896-5715 HCHBQ03 92 923763 AC006172 5593  1-240  847-1425 HCHBQ03 92 923763 AC006099 5594  1-240  736-1424 HCHBQ03 92 923763 AC006103 5595  1-240  737-2325 HCHBQ03 92 923763 AC006098 5596  1-240  736-1424 HCHBQ03 92 923763 AC006106 5597   1-2215 HCHBQ03 92 923763 U82205 5598   1-2213 HCHBQ03 92 923763 U82208 5599   1-2212 HCHBQ03 92 923763 AC006171 5600   1-2213 HCHBQ03 92 923763 AC006177 5601  1-67 1558-1614 1692-2134 2610-2767 4075-4344 5072-5484 5971-6837 7042-7752 HCHBQ03 92 923763 AC006180 5602   1-2213 HCHBQ03 92 923763 AC006171 5603  1-794 HCHBQ03 92 923763 AC006185 5604   1-2206 HCHBQ03 92 923763 AC006184 5605  1-130 HCHBQ03 92 923763 AC006172 5606   1-2211 HCHBQ03 92 923763 AC006099 5607   1-2212 HCHBQ03 92 923763 AC006103 5608   1-2213 HCHBQ03 92 923763 AC006098 5609   1-2212 HCHOA76 95 740102 AL355975 5610  1-322 HCHOA76 95 740102 AC022795 5611  1-300 HCHOA76 95 740102 AL353577 5612  1-279 HCHOA76 95 740102 AC026144 5613  1-183 HCHOA76 95 740102 AC011036 5614  1-193 HCHOA76 95 740102 AC068519 5615  1-312 HCHOA76 95 740102 AL353701 5616  1-168 HCHOA76 95 740102 AC068755 5617  1-190 HCHOA76 95 740102 AC009899 5618  1-175 HCHOA76 95 740102 AC021616 5619  1-57 HCHOA76 95 740102 AC068196 5620  1-316 HCHOA76 95 740102 AL162741 5621  1-45 HCHOA76 95 740102 AC011994 5622  1-154  930-1106 1119-1633 2173-2298 HCHOA76 95 740102 AC002369 5623  1-586 2559-2651 3329-3426 3756-5088 HCHOA76 95 740102 AC068196 5624  1-214 HCHOA76 95 740102 AL162741 5625  1-102 HCHOA76 95 740102 AC002369 5626  1-228 HCHOD89 96 954866 AC025769 5627  1-58 297-454 1087-1366 2938-3671 3704-3938 3973-5157 5160-7151 7263-7543 7894-8226 9524-9649 11707-11942 12187-13327 HCHOD89 96 954866 AC008537 5628   1-1186 HCHOD89 96 954866 AC019337 5629   1-1182 HCHOD89 96 954866 AC008537 5630   1-1993 2105-2385 2736-3068 4364-4489 6546-6781 7025-8165 HCHOD89 96 954866 AC019337 5631   1-1991 2103-2383 2734-3066 4360-4485 6541-6776 7021-8159 HCHOD89 96 954866 AC008537 5632  1-734  767-1001 HCHOD89 96 954866 AC019337 5633  1-158 291-565 598-832 HCHQB06 98 934941 AC073251 5634  1-409 HCOMZ41 100 932878 AC006512 5635  1-83  936-1185 HCOMZ41 100 932878 U47924 5636  1-459  955-1204 HCOMZ41 100 932878 AC006512 5637  1-158 424-946 1266-1460 1769-1850 2324-2667 4720-5597 7030-7663 8193-8438 8565-8902 9074-9181 9552-9638 9830-9997 11068-11206 11336-11497 12752-13412 13503-13691 13754-13853 14203-14738 HCOMZ41 100 932878 AC006512 5638  1-818  963-1440 1469-1958 2220-3076 3455-3663 3931-4285 4549-4632 4696-5069 5245-5337 5461-5775 HCOMZ41 100 932878 U47924 5639  1-158 424-946 1266-1460 1769-1850 2324-2667 4720-5597 7030-7663 8193-8438 8565-8902 9074-9181 9552-9638 9830-9997 11068-11206 11336-11497 12752-13412 13503-13691 13754-13853 14203-14738 HCOMZ41 100 932878 U47924 5640  1-818  963-1440 1469-3076 3455-3663 3931-4285 4549-4632 4806-4965 4979-5001 5245-5337 5461-5775 HCOOG04 101 925748 AC012589 5641  1-524 HCOOG04 101 925748 AC012589 5642   1-2408 3890-4040 4216-4268 7091-7175 HCOOI07 102 951665 AC074191 5643  1-710 HCOOI07 102 951665 AC022240 5644  1-710 HCOOM77 103 969161 AC025572 5645  1-516 HCOOX10 104 961595 AC005005 5646  1-484  517-1142 2842-3176 3376-3493 3575-3740 3873-4227 4728-4935 5074-5351 5446-5564 5772-5960 7287-7627 7721-8097 8218-9325 12098-12161 12780-13266 13482-13666 13748-13817 14445-14519 14595-14928 15658-15754 15848-15923 16016-16112 16512-16660 21313-21448 21710-21870 21899-22470 22634-22787 23169-23307 HCOOX10 104 961595 AC005005 5647  1-368 1579-2971 HCOOZ11 105 965306 AL022238 5648  1-121 899-983 1445-1513 2166-3430 3550-3763 3859-3972 4449-4595 4960-5152 5385-5529 5744-5972 6327-7067 7097-7152 7210-8073 8079-8680 8772-11399 12956-13517 13736-14155 14311-14753 16294-16357 16648-16806 16874-17059 17685-17787 HCOOZ11 105 965306 AL022238 5649  1-540 HCOOZ11 105 965306 AL022238 5650  1-665 HCOQE11 107 965299 AL132777 5651  1-788  884-2272 HCOQE11 107 965299 AL132777 5652  1-312 HCOQQ07 109 951658 AC013267 5653  1-734  831-1524 HCOQQ07 109 951658 AC013267 5654  1-103 HCOQQ07 109 951658 AC013267 5655  1-620 HE8SG46 110 961388 AC022598 5656   1-2668 HE8SG46 110 961388 AC022598 5657  1-144 199-788 HEAAB77 112 574510 AC063924 5658  1-365 HEAAB77 112 574510 AC009248 5659  1-365 HEAAK46 113 574232 AC023160 5660  1-864 HEAAK46 113 574232 AC023157 5661  1-675 HEAAK46 113 574232 AC023157 5662  1-413 HEAAM16 114 574008 AC036239 5663  1-354 HEAAV10 120 968200 AL031178 5664  1-591  631-1516 1572-2046 2329-2724 3570-3721 4393-5225 5256-5351 5672-6501 6686-7086 8367-8855 9380-9440 HEAAV10 120 968200 AL031178 5665  1-343 411-542 HEAAV10 120 968200 AL031178 5666   1-1427 HEEAD64 123 741305 AC011457 5667  1-795 2400-2512 HEEAD64 123 741305 AC006116 5668  1-795 2400-2512 HEEAD64 123 741305 AC011457 5669  1-391 HEEAD64 123 741305 AC006116 5670  1-391 HEEAH07 124 851219 AC019039 5671  1-112 HEEAK84 128 780838 AC004549 5672  1-570 HEEAK84 128 780838 AC004549 5673  1-873 HEEAL31 129 887312 AP000872 5674   1-1131 HEEAL31 129 887312 AP001533 5675   1-1134 HEEAL31 129 887312 AC020735 5676   1-1130 HEEAL31 129 887312 AP000872 5677  1-523 HEEAL31 129 887312 AP001533 5678  1-527 HEEAL31 129 887312 AP001533 5679  1-330 HEEAL31 129 887312 AC020735 5680  1-330 HEEAL31 129 887312 AC020735 5681  1-527 HEEAN24 130 676721 AC073835 5682  1-519 HEEAN24 130 676721 AC012366 5683  1-656 HEEAN24 130 676721 AC012366 5684  1-633  782-1160 HEEAN24 130 676721 AC073835 5685  1-379 HEEAS58 131 735620 AC022730 5686  1-562 HEEAU79 132 706935 AC069419 5687  1-744 HEEAU79 132 706935 AC011311 5688  1-744 HEEAU79 132 706935 AC011311 5689  1-316 HEEAU79 132 706935 AC011311 5690  1-500 3112-3179 3264-3366 4303-4458 5803-5999 6173-6605 7699-7818 8085-8264 12380-13064 13449-14180 14198-14750 15016-15543 15578-15659 16183-16694 17010-19286 HBEAW01 133 851213 AC003117 5691  1-384 HEEAW01 133 851213 AC003117 5692  1-289 HEEAW13 134 656299 AC005344 5693   1-1022 HEEAW13 134 656299 AC005344 5694  1-612 HEEAW13 134 656299 AC005344 5695  1-569 HEGAA24 135 676716 AC015818 5696  1-416 HEGAA24 135 676716 AC022319 5697  1-416 HEGAA24 135 676716 AC022596 5698  1-429 HEGAA24 135 676716 AC005324 5699  1-419 HEGAA24 135 676716 AL353996 5700  1-429 HEGAA24 135 676716 AC015818 5701  1-435 HEGAA24 135 676716 AC022596 5702  1-435 HEGAA24 135 676716 AC022319 5703  1-435 HEGAA24 135 676716 AC005324 5704  1-435 HEGAA24 135 676716 AL353996 5705  1-434 HEGAB84 137 823900 AC007040 5706  1-750 1028-1687 2050-2327 3305-3352 HEGAB84 137 823900 AC007040 5707  1-513 HEGAB84 137 823900 AC007040 5708  1-745 1107-1335 HEGAC95 139 965183 AC073320 5709  1-215 450-550 751-963 1947-2154 3417-3891 4361-4477 4682-5067 5123-5417 5449-5561 5673-6658 HEGAC95 139 965183 AC073320 5710  1-100 HEGAI82 140 955291 AP000714 5711  1-650 HEGAI82 140 955291 AP000846 5712  1-115 271-361 1605-1883 4909-5743 6439-7086 HEGAI82 140 955291 AP000869 5713  1-113 274-364 1609-1887 4913-5749 6445-7388 HEGAI82 140 955291 AP000941 5714  1-316 353-846 1544-2355 HEGAI82 140 955291 AP000714 5715  1-104 HEGAI82 140 955291 AP000846 5716  1-421 HEGAI82 140 955291 AP000869 5717  1-421 HEGAK04 141 887299 AP001319 5718  1-790 HEGAK04 141 887299 AP000485 5719  1-789 HEGAK04 141 887299 AP001319 5720  1-471  761-1159 2076-2471 3129-4172 5710-6153 HEGAK04 141 887299 AP000485 5721  1-471 HEGAK04 141 887299 AP001319 5722  1-106 HEGAK04 141 887299 AP000485 5723  1-106 HEGAO83 142 780837 AC024009 5724  1-880 1967-2289 2746-2890 3236-3284 HEGAO83 142 780837 AC040991 5725  1-880 1967-2288 2745-2889 3235-3283 HEGAO83 142 780837 AC040991 5726  1-176 HEGAP06 143 934705 AC016324 5727  1-870 HLGAP06 143 934705 AC016324 5728  1-465 HEGAP31 144 697419 U73167 5729  1-462 537-572 1142-1632 1720-2993 3778-4687 5675-5764 5875-6565 HEGAP31 144 697419 U90094 5730  1-462 537-572 1142-1632 1720-2993 3778-4687 5675-5764 5875-6565 HEGAP31 144 697419 U73167 5731  1-47  235-1145 HEGAP31 144 697419 U73167 5732  1-463  947-1439 1459-1899 1984-2068 2160-2287 2366-3007 3094-3248 3517-3657 3744-3873 3944-4147 4183-4867 HEGAP31 144 697419 U90094 5733  1-463  947-1439 1459-1899 1984-2068 2160-2287 2366-3007 3094-3248 3517-3657 3744-3873 3944-4147 4183-4867 HEGAP31 144 697419 U90094 5734  1-47  235-1145 HEGAP36 145 706951 AL160314 5735  1-558 HEGAP36 145 706951 AC023226 5736  1-558 HEGAP36 145 706951 AL160314 5737  1-316 HEGAP36 145 706951 AC023226 5738  1-194 HEGAY32 147 699906 AP000759 5739  1-156  199-2013 HEGAY52 148 726316 AC004863 5740  1-272 2151-2257 4711-4808 5669-5932 HEGAY52 148 726316 AC004863 5741  1-517 HEGAY52 148 726316 AC004863 5742  1-307 HEPAA44 150 509456 AP002440 5743  1-554 HEPAD40 153 509002 AC022486 5744  1-599 HEPAD40 153 509002 AC007379 5745  1-599 HEPAD40 153 509002 AC068541 5746  1-599 HEPAD82 154 509452 AC012054 5747  1-199 HEPAD82 154 509452 AC012054 5748  1-367 HEPAK41 157 925146 AL355987 5749   1-1171 2141-2215 2661-2998 3515-3894 HEPAK41 157 925146 AL355987 5750  1-412 HEPAM29 158 508706 AC068515 5751  1-403 HEPAM29 158 508706 AC012256 5752  1-629 HEPAN19 159 508694 AC018422 5753  1-656 HEPAN19 159 508694 AC018422 5754  1-488 HEPAP02 160 926914 AC005041 5755  1-68  87-493 711-838  997-1167 2227-2960 3326-4641 4768-5786 HEPAP02 160 926914 AC005041 5756   1-2920 3439-3667 3839-4332 HEPAP02 160 926914 AC005041 5757  1-143 HEPAP12 161 968771 AC022123 5758  1-704 HEPAS44 162 884083 AC005042 5759  1-526 2088-2310 2826-3158 3165-3449 3645-4062 5680-6042 9261-9489  9723-10014 10575-10710 12839-14011 17421-17570 17625-17808 19953-20102 20972-21402 21801-22496 23146-23452 25891-26147 27915-28163 36900-37086 40102-40222 40334-40438 41262-41858 42042-42215 44623-45334 45461-45648 47989-48685 52151-52529 52651-52771 55505-56703 57348-57424 58261-58444 58449-58644 58759-59136 59195-60637 HEPAS44 162 884083 AC005042 5760  1-505 HEPBB24 164 508684 AC010862 5761  1-649 HEPBB24 164 508684 AC010862 5762  1-345 HEPBB60 165 855597 AC021139 5763  1-570 HEPBB60 165 855597 AC021139 5764  1-373 HEPBG26 166 967921 AL117692 5765  1-362 HEPBG26 166 967921 AL117692 5766  1-680 HEPBG35 167 508686 AL390242 5767  1-235 HEPBG35 167 508686 AC073965 5768  1-758 HEPBG35 167 508686 AL357055 5769  1-522 HEPBG35 167 508686 AC006286 5770  1-759 HEPBG35 167 508686 AL357055 5771  1-307 HEPBG35 167 508686 AC073965 5772  1-308 HEPBG35 167 508686 AC006286 5773  1-307 HEPBH38 169 707524 AC021881 5774  1-353 HEPBO69 171 888697 AC004464 5775  1-565 HEPBQ47 172 713836 AC015624 5776  1-243 HEPBQ47 172 713836 AC011743 5777  1-94 853-988 2270-2334 3850-4276 4554-4835 5824-5974 7894-8034 9229-9353 10526-10939 11126-11250 12266-13223 HEPBQ47 172 713836 AC009948 5778  1-125 1141-2098 HEPBQ47 172 713836 AC011743 5779  1-238 HEPBQ47 172 713836 AC009948 5780  1-414 HEPBQ47 172 713836 AC011743 5781  1-914 HEPBQ47 172 713836 AC009948 5782  1-914 HEPBQ69 173 888693 AC011799 5783  1-573 HEPBQ69 173 888693 AC011799 5784  1-413 HEPCD36 176 523670 AC009789 5785  1-379 503-587 1930-2188 3201-5184 HEPCD36 176 523670 AC009789 5786  1-513 HEPCD36 176 523670 AC009789 5787  1-270 HEPCE25 177 529343 AL121747 5788  1-823 HEPCE25 177 529343 AL034548 5789  1-823 HEPCE25 177 529343 AL121747 5790  1-277 HEPCE25 177 529343 AL034548 5791  1-277 HEPCE25 177 529343 AL121747 5792   1-2350 HEPCE25 177 529343 AL034548 5793   1-2350 HEPCO59 178 761094 AC025879 5794   1-1719 HEPCO59 178 761094 AC025879 5795  1-457 HEPCT32 179 947081 AC010458 5796  1-95 HETAD29 186 509311 AP001043 5797  1-816 HETAD29 186 509311 AP001042 5798  1-810 HETAD29 186 509311 AF017257 5799  1-816 HETAF20 187 509308 AC002357 5800  1-143 3480-3539 5870-5907 9786-9929 11763-11888 14141-14317 14874-15265 16913-17243 17405-17765 18111-18491 18570-19232 19921-20301 20521-21086 21437-21767 22569-25231 HETAF89 189 509300 AF209069 5801  1-42 627-676  926-1197 2577-2756 3159-3250 3354-3404 3563-3766 4737-4811 4915-5019 5614-5717 5891-6054  6953-10137 10601-11304 HETAF89 189 509300 AF209069 5802  1-282 HETAH66 191 799665 AL359837 5803  1-152 1095-1459 1529-1686 1768-2184 3567-3774 HETAH66 191 799665 AC022000 5804  1-152 1095-1459 1529-1686 1768-2183 3566-3773 HETAH66 191 799665 AL359837 5805  1-219 HETAH66 191 799665 AC022000 5806  1-219 HETAJ26 193 508994 AC020735 5807  1-319 HETAJ26 193 508994 AP000625 5808  1-319 HETAJ26 193 508994 AP001316 5809  1-319 HETAJ26 193 508994 AP000625 5810  1-235 HETAJ26 193 508994 AC020735 5811  1-235 HETAJ26 193 508994 AP001316 5812  1-235 HETAN20 195 535359 AC008073 5813   1-1294 3599-3707 4513-4798 5381-5564 5925-6561 8244-8701 8863-8961 10664-10831 11576-11793 12389-12512 13290-13372 16310-16396 16608-17366 17426-17785 17827-19011 HETAN20 195 535359 AC009228 5814   1-1294 3599-3707 4513-4798 5381-5564 5925-6561 8244-8701 8863-8961 10664-10831 11576-11793 12389-12512 13290-13372 16310-16396 16608-17366 17426-17785 17827-19011 HETAN20 195 535359 AC008073 5815  1-164 HETAN20 195 535359 AC009228 5816  1-164 HETAN20 195 535359 AC008073 5817  1-276 HETAN20 195 535359 AC009228 5818  1-276 HETAP59 196 509118 AL133312 5819   1-1081 HETAP59 196 509118 AL135752 5820  1-743  933-2013 HETAP59 196 509118 AL135752 5821  1-90 528-930 3903-3971 HETAR06 198 960839 AC022399 5822  1-734 1441-2849 HETAR06 198 960839 AP000893 5823  1-735 1442-2850 HETAR60 199 934444 AC026407 5824  1-219 636-859 1024-1742 1914-2559 3181-3527 3853-5646 HETAR60 199 934444 AC011394 5825  1-646 1267-1613 1934-3732 HETAR60 199 934444 AC011394 5826  1-719 HETAZ13 201 536192 AL359915 5827  1-328 HETAZ13 201 536192 AL359915 5828  1-183 HETAZ13 201 536192 AL359915 5829  1-540 HETBA01 202 509189 AL356965 5830  1-286 549-787  873-1395 4371-5746 HETBA01 202 509189 AL356965 5831  1-608 HETBF45 203 508655 AC025187 5832  1-330 HETBF45 203 508655 AC034218 5833  1-330 HETBF45 203 508655 AC025187 5834  1-145 HETBF45 203 508655 AC034218 5835  1-145 HETBH48 204 720853 AC021230 5836  1-311 HETBH48 204 720853 AL390840 5837  1-311 HETBH48 204 720853 AL355523 5838  1-311 HETBH48 204 720853 AC021230 5839  1-264 HETBH48 204 720853 AL390840 5840  1-264 HETBH48 204 720853 AC021230 5841  1-353 HETBH48 204 720853 AL355523 5842  1-264 HETBH48 204 720853 AL390840 5843  1-354 HETBH48 204 720853 AL355523 5844  1-236 264-294 HETCH92 210 921390 AC019233 5845  1-244 HETCH92 210 921390 AC019233 5846  1-193 HETDD18 213 509110 AC072058 5847  1-421 HETDD18 213 509110 AC025218 5848  1-421 HETDD18 213 509110 AC025218 5849   1-1149 HETDE67 214 883018 AC037444 5850  1-531 HETDE67 214 883018 AC010679 5851  1-531 HETDE67 214 883018 AC037444 5852  1-604 1500-1699 2148-2589 2820-3674 3750-4272 4335-4872 5843-6194 6565-6670 6675-7299 7494-8026 8163-8907 HETDE67 214 883018 AC010679 5853  1-604 1500-1699 2148-2589 2820-3674 3750-4272 4335-4872 5843-6194 6565-6670 6675-7299 7494-8026 8163-8907 HETDL92 218 508990 AC074236 5854  1-264 HETDL92 218 508990 AC074236 5855  1-435 HETDN90 219 695021 AC025545 5856  1-259 HETDN90 219 695021 AC069523 5857  1-258 HETDN90 219 695021 AC025545 5858  1-465  616-1158 HETDN90 219 695021 AC069523 5859  1-114 2644-2745 HETDN90 219 695021 AC069523 5860  1-791  942-1485 HETDW59 222 827093 AL121780 5861  1-284 HETDW59 222 827093 AL121900 5862  1-284 HETDW59 222 827093 AL121780 5863  1-465 HETDW59 222 827093 AL121780 5864  1-310 HETDW59 222 827093 AL121900 5865  1-465 HETDW59 222 827093 AL121900 5866  1-310 HETEB68 223 917400 AC011031 5867  1-102 1406-1757 2809-2924 3135-3217 3311-4155 HETEB68 223 917400 AC011031 5868  1-568  768-1144 HETEB68 223 917400 AC011031 5869  1-182 HETEZ43 225 529591 AL034400 5870  1-163 5267-5398 5504-5654 6565-6700 7275-7412 8080-8260  8342-10872 HETEZ43 225 529591 AL034400 5871  1-497 HETFA40 226 523112 AL358813 5872  1-474 HETFA40 226 523112 AC025992 5873   1-1759 HETFA40 226 523112 AL162612 5874   1-1431 1501-1692 1855-3146 3686-4006 4703-6498 HETFA40 226 523112 AL356957 5875  1-502 HETFA40 226 523112 AC018593 5876   1-1430 1500-1691 1854-3144 3684-3985 4696-6493 HETFA40 226 523112 AL137798 5877   1-1194 HETFA40 226 523112 AL021920 5878   1-1194 HETFA40 226 523112 AC021338 5879   1-1194 HETFA40 226 523112 AL358813 5880  1-756 HETFA40 226 523112 AC025992 5881  1-302 HETFA40 226 523112 AL162612 5882  1-384 HETFA40 226 523112 AL162612 5883  1-850 HETFA40 226 523112 AL356957 5884  1-321 HETFA40 226 523112 AL356957 5885  1-415 HETFA40 226 523112 AC018593 5886  1-332 HETFA40 226 523112 AL137798 5887  1-144  677-1009 HETFA40 226 523112 AC018593 5888   1-1496 HETFA40 226 523112 AL137798 5889  1-266 HETFA40 226 523112 AL021920 5890  1-130 HETFA40 226 523112 AL021920 5891  1-266 HETFA40 226 523112 AC021338 5892  1-340 HETFC82 227 799658 AC003117 5893  1-798 HETFC82 227 799658 AC003117 5894   1-4842 HETFI81 231 523398 AC007405 5895  1-39  892-1999 2103-2501 3264-3326 6690-6768 7849-8001 8366-8551 8558-8601 9768-9873 10994-11103 12261-12621 12779-12873 13681-15129 HETFI81 231 523398 AC007405 5896  1-194 HETHD30 241 935175 AC021808 5897  1-330 1298-2514 2943-2975 HETHD30 241 935175 AC021808 5898  1-312 HETHE56 242 974348 AC007334 5899   1-1691 HETHE56 242 974348 AC007608 5900   1-1691 HETHE56 242 974348 AC007334 5901   1-1017 1671-2298 2580-3268 HETHE56 242 974348 AC007334 5902  1-56  840-2379 HETHE56 242 974348 AC007608 5903   1-1017 1671-2298 2580-3268 HETHE56 242 974348 AC007608 5904  1-56  840-2379 HETHH49 243 967737 AC015645 5905  1-627 HETHH49 243 967737 AC009700 5906  1-77 214-306 404-519 1182-1825 6494-6614 HETHH49 243 967737 AC009700 5907  1-322 HETHH49 243 967737 AC009700 5908  1-309 HETHO78 245 963592 AC009789 5909   1-1348 HETHO78 245 963592 AC009789 5910  1-517 HETHR24 246 851412 AC024555 5911  1-65 1322-1814 1879-2084 2488-3174 3624-4306 4653-4875 5942-7911 HETHR24 246 851412 AL356796 5912  1-206  610-1296 1746-2428 2774-2996 4063-5628 HETHR24 246 851412 AL356796 5913  1-493 HETHT53 247 974555 AL049750 5914  1-611 HETHT53 247 974555 Z69905 5915  1-611 HETIF01 248 966185 AC016135 5916  1-845 HETIF01 248 966185 AC018512 5917  1-776 HETIF01 248 966185 AC002518 5918  1-150 HETIG71 249 974359 AC009528 5919  1-558 1659-1824 HETIG71 249 974359 AC009528 5920  1-316 HETIU60 253 739804 AC022922 5921  1-726 HETIU60 253 739804 AC022922 5922  1-103 HETJD86 256 909130 AC019027 5923  1-675 HETJD86 256 909130 AL049869 5924  1-233 2467-2605 3956-4685 4819-5326 5669-6024  6878-10901 HETJD86 256 909130 AC019027 5925   1-3169 HETJD86 256 909130 AL049869 5926  1-165 HETJI32 258 806435 AL021997 5927   1-1175 HETJI32 258 806435 AL358785 5928   1-1175 HETJK67 259 751072 AL158821 5929  1-506 HETIN51 260 767932 AC012135 5930  1-562 HETIN51 260 767932 AL160153 5931  1-562 HETIN51 260 767932 AC012135 5932  1-469 HETIN51 260 767932 AC012135 5933  1-58 2070-2379 2778-3068 3566-4200 4240-6571 6587-7743 7870-9821 HETIN51 260 767932 AL160153 5934  1-58 2070-2379 2778-3068 3566-4200 4240-6572 6588-7744 7871-9824 HETIN51 260 767932 AL160153 5935  1-469 HETJT95 261 789310 AP001961 5936  1-788  872-1462 HETJT95 261 789310 AP001961 5937  1-158 423-565 2290-2739 HETJX04 262 927120 AL390040 5938  1-54 340-441  969-1131 3544-3961 5786-5896 7026-7372 7541-8076 8303-8737 10369-10513 10949-11077 11323-13046 HETJX04 262 927120 AL390040 5939  1-616 881-994 HETJY11 263 966194 AC016653 5940  1-112 HETJY11 263 966194 AL353659 5941  1-44  263-3729 HETKG67 265 974355 AC055774 5942  1-732 HETKH01 266 915320 AC022922 5943  1-726 HETKH01 266 915320 AC022922 5944  1-103 HETKQ65 269 855449 AC002098 5945  1-106 632-766 1032-1392 1896-2014 2340-2921 3822-3955 HETKQ65 269 855449 AC002320 5946  1-103 629-763 1029-1389 1893-2007 2337-2918 3819-3952 HETKX91 271 789797 AC026967 5947  1-641 HETKX91 271 789797 AC073356 5948  1-641 HETKX91 271 789797 AC068762 5949  1-641 HETLB04 273 920894 AC019073 5950  1-780 5430-5615 7641-7685 10826-10887 11255-11332 12359-12669 13590-13776 16097-16197 16225-16569 17409-17588 17614-18145 18212-18277 20025-20135 21203-21289 21668-21798 22067-22836 22902-23233 23289-24983 HETLB04 273 920894 AC009079 5951  1-780 1966-2659 5432-5617 7643-7687 10830-10891 11259-11336 12363-12673 13594-13780 16101-16201 16229-16573 17510-17593 17618-18149 18216-18281 20020-20130 21198-21284 21663-21793 22060-22829 22895-23226 23282-24977 HETLB04 273 920894 AC019073 5952  1-464 HETLB04 273 920894 AC009079 5953  1-454 HETLH89 274 786458 AC067828 5954  1-788 HETLH89 274 786458 AC019036 5955  1-788 HETLH89 274 786458 AC067828 5956   1-1399 HETLH89 274 786458 AC019036 5957   1-1399 HETLM46 275 974361 AC006478 5958  1-445 HETLM46 275 974361 AC018701 5959  1-445 HETLM46 275 974361 AC006478 5960  1-564 HETLM46 275 974361 AC018701 5961  1-564 HJMAZ84 277 919847 AC026443 5962  1-611 670-740 1340-1557 3026-3108 3944-4508 HJMAZ84 277 919847 AC025183 5963  1-611 670-740 1340-1557 3025-3107 3942-5084 HJMAZ84 277 919847 AC025181 5964  1-611 670-740 1342-1559 3027-3109 3945-5087 HJMAZ84 277 919847 AC025183 5965  1-468 HJMAZ84 277 919847 AC026443 5966  1-775 HJMAZ84 277 919847 AC025181 5967  1-468 HJMAZ84 277 919847 AC025183 5968  1-775 HJMAZ84 277 919847 AC025181 5969  1-775 HLMNG77 279 675752 AC020663 5970  1-984 1841-2130 2448-2547 2956-3100 4344-4618 5421-5525 5635-6174 6314-6432 6805-7332 8210-8382 8813-9096 9125-9321  9861-10195 11530-11672 12829-13010 14776-14925 HLMNG77 279 675752 AC020663 5971  1-265 HLWAB50 280 856552 AC016118 5972  1-100 169-643 832-1541 HLWAB50 280 856552 AC008728 5973  1-100 169-643  832-1541 HLWAB50 280 856552 AC016118 5974  1-377 HLWAB50 280 856552 AC008728 5975  1-377 HLWAB50 280 856552 AC016118 5976  1-456 HLWAB50 280 856552 AC008728 5977  1-456 HLWAG51 282 964389 AJ011929 5978   1-5280 5382-8031 HLWAG51 282 964389 AJ011929 5979  1-670 HLWAG51 282 964389 AJ011929 5980   1-1129 HLWAI13 284 920690 AC004231 5981  1-312 317-624  688-1215 5956-6044 6120-6407 7321-7475 8363-8506 8805-8969 9050-9175 10077-10484 11276-11769 11834-12061 12345-12806 12905-12943 13049-13430 13835-14718 HLWAI13 284 920690 AC004231 5982  1-101 HLWAK94 287 715727 AC006513 5983  1-457 2320-4404 4427-5879 5900-7022 7041-9197 9625-9717 HLWAR78 289 723330 AC008741 5984  1-554 1019-1282 HLWAR78 289 723330 AC011271 5985  1-554 1019-1282 HLWAR78 289 723330 AC008741 5986   1-7073 HLWAR78 289 723330 AC011271 5987   1-7072 HLWAR78 289 723330 AC008741 5988  1-331 HLWAR78 289 723330 AC011271 5989  1-331 HLWAU18 290 666273 AC023255 5990  1-153 HLWAU18 290 666273 AC016839 5991  1-163 HLWAU18 290 666273 AC009648 5992  1-182 HLWAU18 290 666273 AC007194 5993  1-134 HLWAU18 290 666273 AC040991 5994  1-110 HLWAU18 290 666273 AC016839 5995  1-365 HLWBA25 292 677944 AP001629 5996  1-789  792-2201 HLWBA25 292 677944 AP001629 5997  1-168 HLWBE31 293 934562 AC018355 5998  1-334 HLWBE31 293 934562 AC034187 5999  1-334 HLWBE31 293 934562 AC025210 6000  1-334 HLWBE31 293 934562 AC018355 6001  1-415 HLWBE31 293 934562 AC034187 6002  1-472 HLWBE31 293 934562 AC025210 6003  1-415 HLWBE31 293 934562 AC018355 6004  1-472 HLWBE31 293 934562 AC034187 6005  1-415 HLWBE31 293 934562 AC025210 6006  1-471 HLWBE92 294 791362 AC020779 6007   1-1023 1224-2000 HLWBE92 294 791362 AC020779 6008  1-469 HLWBE92 294 791362 AC020779 6009  1-292 HLWBJ02 295 919639 AL133404 6010  1-377 HLWBJ02 295 919639 AL133404 6011   1-1203 HLWBK40 296 711000 AP000813 6012  1-438 HLWBK40 296 711000 AP001001 6013  1-438 HLWBK40 296 711000 AP000813 6014  1-302 HLWBK40 296 711000 AP001001 6015  1-864 HLWBK40 296 711000 AP001001 6016  1-302 HLWBO68 298 529323 AC007782 6017  1-359 HLWBO68 298 529323 AC007782 6018  1-283 HLWBQ86 300 703465 AL022097 6019  1-467 HLWBQ86 300 703465 AL022097 6020  1-142 HLWBS14 301 925300 AC022536 6021  1-307 HLWBS14 301 925300 AC022536 6022  1-817 HLWBS43 302 774175 AL122017 6023  1-563 HLWBS43 302 774175 AL122017 6024  1-266 HLWBS43 302 774175 AL122017 6025   1-1023 HLWBZ74 303 679215 AC005281 6026   1-1106 HLWCM44 305 727699 AL121578 6027  1-324 HLWCM44 305 727699 AL121578 6028   1-1169 HLWCO66 307 750779 AC019228 6029  1-528 HLWCQ53 308 869700 AC022784 6030  1-873 HLWCQ62 309 742778 AC010092 6031  1-865  912-3137 3529-4043 5834-5942 6891-7010 HLWCQ76 310 768018 AL121897 6032  1-127 1795-2076 2480-2735 3715-3979  6143-10331 HLWCQ76 310 768018 AL121897 6033  1-302 HLWCQ76 310 768018 AL121897 6034  1-518 HLWDD02 313 953283 AL139317 6035  1-425 HLWDD02 313 953283 AL139317 6036  1-464 HLWDD02 313 953283 AL139317 6037  1-157 HLWDE60 314 868276 AL355379 6038  1-184  893-1005 2129-2607 3137-3804 5061-5704 HLWDE60 314 868276 AL355379 6039  1-761 HLWEE76 316 973315 AC025868 6040  1-156 181-506  667-1063 1498-1959 HLWEE76 316 973315 AC025868 6041  1-202 HLWEE76 316 973315 AC025868 6042  1-216 HLWFG82 317 929647 AC024009 6043   1-1072 1285-1807 2970-3240 3323-3578 3718-4021 4167-4681 4900-4999 5291-5493 5601-6055 7662-8405 8579-8892 9250-9591 HLWFG82 317 929647 AC040991 6044   1-1072 1285-1807 2969-3239 3322-3578 3718-4021 4166-4680 5290-5492 5600-6054 7661-8403 8577-8890 9248-9589 11692-12415 HLWFG82 317 929647 AC009955 6045   1-1072 1285-1807 2969-3239 3322-3578 3718-4021 4166-4680 4899-4998 5290-5492 5600-6054 7661-8404 8578-8891 9249-9590 11693-12416 12628-13109 13182-13470 13675-13945 14072-16144 16553-16761 18342-18428 18598-18758 19030-19180 19452-19907 20007-20565 HLWFG82 317 929647 AC040991 6046   1-1023 1743-2217 2502-2917 3075-3422 HLWFG82 317 929647 AC009955 6047  1-604 2136-3385 3537-4031 5661-5910 6207-7370 8204-9136 9469-9651  9951-11649 HLWFG82 317 929647 AC009955 6048   1-1023 1743-2217 2502-2917 3075-3422 HMVDU41 319 957804 AC019103 6049  1-431 HMVDU41 319 957804 AC019103 6050  1-148 496-727 HNBTP01 320 914428 AL022238 6051  1-121 899-983 1445-1513 2166-3430 3550-3763 3859-3972 4449-4595 4960-5152 5385-5529 5744-5972 6327-7067 7097-7152 7210-8073 8079-8680  8772-11399 12956-13517 13736-14155 14311-14753 16294-16357 16648-16806 16874-17059 17685-17787 HNBTP01 320 914428 AL022238 6052  1-540 HNBTP01 320 914428 AL022238 6053  1-665 HNBUR07 324 951814 AP000424 6054  1-418 HNBUR07 324 951814 AF205591 6055  1-417 HNBUR07 324 951814 AP000424 6056  1-828 1172-1743 HNBUR07 324 951814 AF205591 6057  1-670 1172-1746 HNNNA06 326 917723 AC067780 6058   1-2013 HNNNA06 326 917723 AC067780 6059  1-175 HNNNA77 328 917725 AC067780 6060   1-2013 HNNNA77 328 917725 AC067780 6061  1-175 KNOAS06 329 933730 AL358215 6062  1-856 HNOAS06 329 933730 AL390797 6063  1-856 HNOAS06 329 933730 AL390797 6064  1-317 HNOBF57 331 927903 AP000045 6065  1-141 1793-1919 2337-3020 3519-3910 5158-5639 8419-8529 9247-9333 10820-11221 13144-13201 17419-17975 18062-20146 21788-21913 HNOBF57 331 927903 AP000113 6066  1-141 1793-1919 2337-3020 3519-3910 5158-5639 8419-8529 9247-9333 10820-11221 13144-13201 17419-17975 18062-20146 21788-21913 KNOBF57 331 927903 AP000189 6067  1-141 1793-1919 2337-3020 3519-3910 5158-5639 8419-8529 9247-9333 10820-11221 13144-13201 17419-17975 18062-20146 21788-21913 HNOBF57 331 927903 AP000045 6068  1-187 HNOBF57 331 927903 AP000113 6069  1-187 HNOBF57 331 927903 AP000189 6070  1-187 HNOCT39 333 952611 AC025840 6071  1-733 HNOCT39 333 952611 AC025840 6072  1-476 HOCPJ03 336 917484 AC036229 6073  1-440 602-656 1173-1559 1846-2263 2281-2450 2778-3266 HOCPJ03 336 917484 AC036229 6074  1-779 HODAD73 337 973463 AC076959 6075  1-515 HODAD73 337 973463 AC004889 6076  1-515 HODAD73 337 973463 AC076959 6077  1-370 HODAD73 337 973463 AC004889 6078  1-370 HODAD95 338 974043 Z93783 6079  1-726 HODAD95 338 974043 Z93783 6080  1-229 HODAD95 338 974043 Z93783 6081  1-307 HODAG37 339 529410 AC069320 6082  1-230 HODAG37 339 529410 AC069320 6083  1-376 HODAH32 340 859509 AC004976 6084  1-324 HODAH32 340 859509 AC004976 6085  1-298 HODAJ35 342 529405 AC008781 6086  1-333 HODAJ35 342 529405 AC005618 6087  1-333 HODAJ35 342 529405 AC008781 6088  1-326 HODAJ35 342 529405 AC008781 6089  1-125 HODAJ35 342 529405 AC005618 6090  1-326 HODAJ35 342 529405 AC005618 6091  1-125 HODAK38 343 529404 AC068204 6092  1-383 HODAK95 344 960179 AC010271 6093  1-75 266-889 1331-1431 2199-2234 2779-3277 3445-3965 4895-5797 HODAK95 344 960179 AC010271 6094  1-136 2057-2217 3443-3543 4471-4543 6172-7809 HODAV80 347 859519 AC010761 6095  1-364 HODAV80 347 859519 AP000878 6096  1-364 HODAV80 347 859519 AC010761 6097  1-812 HODAV80 347 859519 AP000878 6098  1-767  917-1223 1455-2831 HODAW84 349 775425 AC074185 6099   1-1154 1220-1578 1593-2367 2514-3351 HODAW84 349 775425 AC019096 6100   1-1208 1356-2248 HODAW84 349 775425 AC018738 6101  1-82  829-1986 2050-2409 2424-3174 3345-4236 HODAW84 349 775425 AC017104 6102  1-774  922-1813 HODAW84 349 775425 AC019096 6103  1-392 HODAW84 349 775425 AC018738 6104  1-401 HODAW84 349 775425 AC017104 6105  1-392 HODBC01 350 921662 AC022088 6106  1-887 HODBC01 350 921662 AC012589 6107  1-887 HODBC01 350 921662 AC022088 6108  1-123 H0DBC01 350 921662 AC012589 6109  1-123 HODBC01 350 921662 AC022088 6110  1-662 HODBC01 350 921662 AC012589 6111  1-662 HODBC07 351 954161 AC055755 6112  1-340 HODBC07 351 954161 AP000767 6113  1-340 HODBC07 351 954161 AP000645 6114  1-340 HODBC07 351 954161 AP000767 6115  1-346 HODBC07 351 954161 AP000645 6116  1-346 HODBC07 351 954161 AC055755 6117  1-346 HODBC07 351 954161 AP000767 6118  1-861 HODBC07 351 954161 AP000645 6119  1-861 HODBE01 352 921655 AC023783 6120  1-180 HODBE01 352 921655 AC023783 6121  1-180 HODBH16 353 927781 AC008826 6122  1-286 HODBH16 353 927781 AC016613 6123  1-286 HODBT58 355 678444 AC027551 6124  1-100 HODBT58 355 678444 AC021649 6125  1-376 HODBT58 355 678444 AC008557 6126  1-376 HODBT58 355 678444 AC022493 6127  1-311 HODBT58 355 678444 AC008557 6128  1-338 HODBT58 355 678444 AC022493 6129  1-338 HODBV71 357 761447 AC026372 6130   1-1224 HODBV71 357 761447 AC044856 6131   1-1147 HODBV71 357 761447 AC073288 6132   1-1147 HODBV71 357 761447 AC044856 6133  1-166 HODBV71 357 761447 AC073288 6134  1-150 HODBV71 357 761447 AC026372 6135  1-424 HODBV71 357 761447 AC044856 6136  1-425 HODBV71 357 761447 AC073288 6137  1-425 HODCA11 358 967732 AC006977 6138  1-383 394-499 2564-2769 3617-3753 3863-4531 5760-6332 8307-8374 8604-8902 9558-9675 11022-11171 12838-12958 13542-13671 13770-13950 14233-14631 14669-14765 17151-17350 18504-18643 20745-20834 22291-22452 26464-26681 26756-26866 28190-28224 29994-30139 30933-31056 HODCJ11 362 967320 AC025415 6139  1-477 HODCJ11 362 967320 AC025415 6140  1-431 HODCJ42 363 932638 AC011618 6141  1-697 HODCJ42 363 932638 AC011618 6142  1-323 HODCL88 364 529334 AC026046 6143  1-398  848-1362 HODCL88 364 529334 AC026046 6144  1-797 HODCL88 364 529334 AC026046 6145  1-290 HODCM62 365 859556 AC018774 6146  1-302 HODCO09 366 573202 AC069378 6147  1-412 HODCO09 366 573202 AC012425 6148  1-412 HODCO09 366 573202 AL132661 6149  1-412 HODCO09 366 573202 AC044855 6150  1-412 HODCO09 366 573202 AC069378 6151  1-411 HODCO09 366 573202 AC012425 6152  1-338 HODCO09 366 573202 AL132661 6153  1-411 HODCO09 366 573202 AC044855 6154  1-338 HODCO09 366 573202 AC069378 6155  1-338 HODCO09 366 573202 AC012425 6156  1-411 HODCO09 366 573202 AL132661 6157  1-338 HODCO09 366 573202 AC044855 6158  1-411 HODCO46 367 573200 AC006407 6159  1-316 HODCO82 368 573195 AC009834 6160  1-500 4451-4574 8243-8369  9901-10227 10315-10434 HODC082 368 573195 AC009834 6161  1-87 799-918 3613-3738 7543-7694 8075-8140 8384-8501 10749-10867 12458-12594 14660-14793 16991-17117 17690-17895 19598-19726 19971-20125 21034-21516 23395-23513 23775-23907 24646-24777 28056-28291 28749-28822 29696-29930 30554-30819 32721-32911 34077-37157 HODCP69 369 507249 AC022080 6162  1-333 HODCP69 369 507249 AC068293 6163  1-333 HODCP69 369 507249 AC019255 6164  1-333 HODCR43 370 529332 AC023162 6165  1-431 HODCR43 370 529332 AC000380 6166  1-430 HODCR43 370 529332 AC000380 6167  1-379 HODCT07 371 954149 AC016510 6168  1-293 HODCU01 372 917270 AL355822 6169   1-1563 HODCU01 372 917270 AL355822 6170  1-132 HODCU01 372 917270 AL355822 6171  1-83 HODCU02 373 920698 AC018633 6172  1-627 HODCU02 373 920698 AC018633 6173  1-648 HODCU02 373 920698 AC018633 6174  1-190 HODCU62 374 524314 AC078826 6175  1-462 HODCU62 374 524314 AC009246 6176  1-463 HODCU62 374 524314 AC078826 6177  1-106 HODCU62 374 524314 AC009246 6178  1-405 HODCV09 375 973487 AC021721 6179  1-603 HODCW17 376 960051 AC023483 6180  1-375 HODCW17 376 960051 AC016092 6181  1-375 HODCW17 376 960051 AC018822 6182  1-375 HODDD20 379 933726 AC023483 6183  1-319 HODDD20 379 933726 AC024636 6184  1-319 HODDD20 379 933726 AC024898 6185  1-319 HODDD20 379 933726 AC023483 6186  1-261 HODDD20 379 933726 AC024636 6187  1-261 HODDD20 379 933726 AC024898 6188  1-261 HODDD41 380 529390 AL357497 6189  1-70 2356-2495 2576-2678 HODDE28 381 529169 AC008063 6190  1-369 HODDE28 381 529169 AC008063 6191  1-411 HODDE28 381 529169 AC008063 6192  1-106 HODDE51 382 937759 AC012362 6193  1-258 HODDF51 382 937759 AC012362 6194  1-466 HODDG57 383 806204 AC068404 6195  1-659  762-1460 HODDG57 383 806204 AC068404 6196  1-405 HODDN59 389 975437 AL160155 6197  1-630 HODDN59 389 975437 AL136961 6198  1-630 HODDN59 389 975437 AL160155 6199  1-540 HODDN59 389 975437 AL136961 6200  1-540 HODDN59 389 975437 AL160155 6201  1-114 HODDN59 389 975437 AL136961 6202  1-114 HODDN93 390 891236 AC024502 6203  1-190 2311-2654 2971-3108 4195-4501 4743-5311 5569-6222 6284-6596  6791-10462 HODDN93 390 891236 AC024502 6204  1-298 HODDQ02 391 920962 AC069225 6205  1-560 762-909 1004-1333 1711-2220 3050-3742 3856-3961 HODDQ02 391 920962 AC016138 6206  1-560 762-909 1004-1333 1711-2220 3050-3742 3856-3961 HODDQ02 391 920962 AC069225 6207  1-531 HODDQ02 391 920962 AC069225 6208  1-403 HODDQ02 391 920962 AC016138 6209  1-531 HODDQ02 391 920962 AC016138 6210  1-403 HODDR13 393 529640 AC021663 6211  1-271 HODDR13 393 529640 AC021663 6212  1-297 HODDS67 394 567197 AC012186 6213  1-101 1432-1773 2108-2234 2755-2942 4452-4677 6207-6294 6910-7030 8184-8720 8935-9043 9126-9538  9680-10164 11135-11344 11744-11906 14393-14679 20063-20220 20444-20625 20961-21364 21744-21893 22016-22076 22652-22911 22942-24288 24334-25010 25159-25619 HODDS67 394 567197 AC009066 6214  1-106 191-603  745-1229 2199-2408 2808-2970 5666-5770 HODDS67 394 567197 AC007225 6215  1-70 5595-5695 7026-7367 7702-7828 8349-8536 10046-10271 11801-11888 12504-12624 13778-14314 14529-14637 14720-15132 15274-15758 16729-16938 17338-17500 20149-20272 HODDS67 394 567197 AC009066 6216  1-538 HODDS67 394 567197 AC007225 6217  1-938 1722-1783 2310-2378 2720-2838 2989-3336 3777-4575 4756-5304 5852-6014 7274-7609 7649-7873 7897-8059 8624-8742 HODDU70 395 529290 AC067917 6218  1-348 HODDU70 395 529290 AC002075 6219  1-348 HODDU70 395 529290 AC067917 6220  1-218 HODDU70 395 529290 AC002075 6221  1-218 HODEA90 397 782242 AL355491 6222  1-899 HODEA90 397 782242 AL356112 6223  1-899 HODEA90 397 782242 AL355491 6224  1-416 HODEA90 397 782242 AL355491 6225  1-301 HODEA90 397 782242 AL356112 6226  1-288 HODEA90 397 782242 AL356112 6227  1-416 HODEB04 398 927022 AL161737 6228  1-785 HODEB04 398 927022 AF011889 6229  1-293  352-1342 1367-1727 2768-3573 3651-3720 4597-4939 4948-5114 5138-5904 6223-6559 7550-7748 8482-8578 9047-9160 9246-9515 10516-10659 11070-11151 11548-11722 26922-26988 27692-27813 28609-28753 30932-30969 31104-31225 32671-32835 37466-37786 38294-38928 HODEG86 405 784833 AC013281 6247  1-277 HODEG86 405 784833 AC013281 6248  1-175 HODEG86 405 784833 AC018988 6249  1-147 HODEG86 405 784833 AC018988 6250  1-277 HODEH22 407 974329 AC068231 6251  1-437 HODEH22 407 974329 AL357752 6252  1-437 HODEH22 407 974329 AC068231 6253  1-287 HODEH22 407 974329 AL357752 6254  1-287 HODEI13 408 859318 AC046158 6255  1-591 HODEI13 408 859318 AC046158 6256  1-409 HODEJ13 408 859318 AC046158 6257  1-433 HODEK50 410 859307 AC007075 6258  1-729 HODEK50 410 859307 AC007075 6259  1-401 HODEL92 411 859313 AL139296 6260  1-470 HODEO87 413 930735 AC069316 6261  1-660 HODEO87 413 930735 AP002762 6262  1-660 HODEO87 413 930735 AC069316 6263  1-253 HODEO87 413 930735 AP002762 6264  1-253 HODEO87 413 930735 AC069316 6265  1-84 HODEO87 413 930735 AP002762 6266  1-84 HODEP12 415 965534 AC012659 6267  1-490 HODEP12 415 965534 AJ132410 6268  1-490 HODEP12 415 965534 AJ132411 6269  1-490 HODEP12 415 965534 AC012659 6270  1-363 HODEP12 415 965534 AJ132410 6271  1-363 HODEP12 415 965534 AJ132411 6272  1-363 HODEP12 415 965534 AJ132410 6273  1-352 HODEP86 416 784846 AC068146 6274  1-512 HODEP86 416 784846 AC009292 6275  1-512 HODEP86 416 784846 AC068146 6276  1-366 HODEP86 416 784846 AC068146 6277  1-252 HODEP86 416 784846 AC009292 6278  1-252 HODEP86 416 784846 AC009292 6279  1-366 HODEQ79 418 859287 AL049820 6280  1-599 HODEQ79 418 859287 AL049820 6281  1-107 HODEQ79 418 859287 AL049820 6282  1-373 HODER91 419 789661 AL136109 6283   1-3030 3212-3814 9089-9408 11724-12242 12308-12959 23153-23254 24314-26013 HODER91 419 789661 AC023147 6284   1-3041 3223-3825 9096-9415 11730-12248 12314-12965 23152-23259 24319-26018 HODER91 419 789661 AC022219 6285   1-3030 3212-3814 9084-9403 11717-12235 12301-12952 23145-23246 24307-26006 HODER91 419 789661 AL136109 6286  1-344 HODER91 419 789661 AL136109 6287  1-174 HODER91 419 789661 AC023147 6288  1-122 HODER91 419 789661 AC022219 6289  1-191 HODER91 419 789661 AC022219 6290  1-344 HODES86 420 784815 AC023311 6291   1-1229 HODES86 420 784815 AC068764 6292   1-1429 HODEY08 425 972984 AC025975 6293  1-155 3629-3751 4620-4829 6019-6195 7728-8138 9330-9484  9973-11639 HODEY08 425 972984 AC025975 6294  1-422 HODEY08 425 972984 AC025975 6295  1-624 HODEY13 426 859323 AC023757 6296  1-683 HODEY13 426 859323 AC023757 6297  1-304 HODEY13 426 859323 AC023757 6298  1-279 HODEY80 427 859296 AL049821 6299  1-892 HODEZ02 428 918672 AC058817 6300  1-78 1016-1502 HODEZ02 428 918672 AL356311 6301  1-635 1058-1135 2074-2560 3280-3551 HODEZ02 428 918672 AL356311 6302  1-650 HODEZ11 429 952166 AL049780 6303  1-79 1741-2345 2372-4365 4520-4951 4965-5086 8909-9080 9623-9884 11171-11276 11444-11552 12317-12505 12525-12605 13051-13119 13647-13742 14956-15395 15412-15622 16059-16168 17969-18042 18135-18576 18752-19394 20745-21012 21580-21955 26195-26275 27457-27874 28194-28464 28567-28646 30337-30467 30873-31422 32480-32632 33300-33564 33909-33994 34103-34189 34258-35147 HODEZ11 429 952166 AC006530 6304  1-79 1741-2345 2372-4365 4520-4951 4965-5086 8909-9080 9623-9884 10977-11278 11446-11554 12290-12489 12509-12589 13035-13103 14941-15380 15397-15607 17239-17337 17953-18026 18119-18560 18736-19378 20729-20996 21563-21938 24485-24568 26177-26257 26973-27081 27090-27231 27439-27856 28176-28446 28549-28628 30319-30449 30855-31404 32460-32612 33295-33452 33889-34006 34238-35127 HODEZ11 429 952166 AL049780 6305  1-76 1605-2548 2583-4747 HODEZ11 429 952166 AL049780 6306   1-1091 HODEZ11 429 952166 AC006530 6307   1-1090 HODEZ11 429 952166 AC006530 6308  1-269 HODFA38 430 934266 AC016992 6309  1-649 HODFB88 433 792979 AC008651 6310  1-368 2142-2889 3649-3930 5148-5773 6717-7220 7679-8094 8917-9211 9671-9754 10002-10093 HODFB88 433 792979 AC008651 6311  1-83 HODFD08 434 958371 AL354943 6312  1-396 HODFD08 434 958371 AL354943 6313  1-322 HODFD45 436 780531 AC009263 6314  1-401 HODFD45 436 780531 AC009263 6315  1-316 HODFH02 439 915257 AC025139 6316  1-706 HODFJ01 441 859549 AC073389 6317  1-509 HODFJ01 441 859549 AC073389 6318  1-401 FODFK18 442 974313 AC068404 6319   1-1251 HODFK18 442 974313 AC068404 6320  1-405 HODFO03 447 859329 AC002044 6321  1-530 HODFP40 449 921651 AC074386 6322  1-622 2363-6063 HODFP40 449 921651 AC004889 6323  1-622 2363-6063 HODFP40 449 921651 AC074386 6324  1-93 HODFP40 449 921651 AC074386 6325   1-1213 HODFP40 449 921651 AC004889 6326   1-1213 HODFP40 449 921651 AC004889 6327  1-93 HODFQ06 451 934304 AL365325 6328  1-529 HODFQ06 451 934304 AL356748 6329  1-529 HODFQ06 451 934304 AC005815 6330  1-529 HODFQ06 451 934304 AL365325 6331  1-290 HODFQ06 451 934304 AL356748 6332  1-290 HODFQ06 451 934304 AC005815 6333  1-290 HODFT52 452 915232 AC069418 6334  1-988 HODFT52 452 915232 AC078803 6335  1-994 HODFU02 453 918536 AC027603 6336  1-601 HODFU02 453 918536 AC011319 6337  1-601 HODFU02 453 918536 AC011319 6338  1-515 HODFU02 453 918536 AC027603 6339  1-515 HODFU47 455 806232 AC069029 6340   1-1072 HODFU47 455 806232 AC055807 6341   1-1072 HODFU47 455 806232 AC069029 6342  1-383 HODFU47 455 806232 AC055807 6343  1-383 HODFU54 456 965526 AC022944 6344  1-584 HODFU54 456 965526 AC022944 6345  1-105 HODFU54 456 965526 AC022944 6346  1-199 HODFW17 457 859322 AC012240 6347  1-592 HODFW17 457 859322 AC018633 6348  1-612 HODFW17 457 859322 AC018633 6349  1-82  84-446 HODFW17 457 859322 AC018633 6350  1-173 HODFX57 458 975259 AC026229 6351  1-420 HODFX57 458 975259 AC022108 6352  1-421 HODFX57 458 975259 AC026229 6353  1-294 HODFX57 458 975259 AC022108 6354  1-295 HODFX57 458 975259 AC026229 6355  1-309 HODFX57 458 975259 AC022108 6356  1-697 HODFY16 459 958329 AL138499 6357  1-74 1171-1414 2003-2145 5281-5390 6571-6708 7273-8042 8498-8581 9242-9411 9823-9893 11229-11269 11959-12050 12418-12490 12981-13017 13172-13255 13739-13807 16333-16490 16856-16966 17025-17457 19018-19053 19571-19708 19739-20018 20071-20166 20847-20919 21057-21542 21820-21861 22375-22563 22606-22687 23332-23536 23934-23974 24441-25133 25607-26151 27567-27728 28089-28180 30591-30662 31711-31750 32025-32303 32728-33189 33569-33660 34582-35243 36002-36089 37700-38027 38479-39379 39447-39994 39996-40412 40939-41175 42777-42859 43613-43709 43834-43926 44676-44750 44978-45061 45219-45304 45604-46116 46592-46981 47116-47969 49128-49249 49765-50272 50400-50495 50679-50942 51613-51736 52713-52789 54124-54402 54837-55118 55215-55764 56143-56632 HODFY16 459 958329 AL138499 6358  1-386  635-1149 HODFY79 460 975253 AC027445 6359  1-644 HODFY79 460 975253 AC061706 6360  1-644 HODFY79 460 975253 AC027445 6361  1-477 HODGC04 462 926863 AC019014 6362  1-244 HODGC61 463 973449 AC020695 6363  1-663 HODGC61 463 973449 AC017086 6364  1-663 HODGC61 463 973449 AL135932 6365  1-663 HODGC61 463 973449 AC020695 6366  1-340 HODGC61 463 973449 AC017086 6367  1-340 HODGC61 463 973449 AL135932 6368  1-340 HODGD05 464 931071 AL355304 6369  1-176 HODGD05 464 931071 AL355307 6370  1-176 HODGD05 464 931071 AL355304 6371  1-90 HODGD05 464 931071 AL355307 6372  1-90 HODGD05 464 931071 AL355307 6373  1-408 HODGH11 468 965105 AL133463 6374  1-642 HODGH11 468 965105 AL050320 6375  1-642 HODGH91 469 968794 AL033547 6376  1-520 HODGH91 469 968794 AL033547 6377  1-567 HODGH91 469 968794 AL033547 6378  1-429 HODGJ67 471 974297 AL356804 6379  1-414 HODGL54 472 859303 AC023785 6380  1-300  990-1082 1263-1944 3930-3960 4456-4565 4991-5162 7643-7924 8196-8928 10082-10445 HODGL54 472 859303 AC023785 6381  1-484 1470-1673 HODGL54 472 859303 AC023785 6382  1-576 HODGM46 473 974051 AC002351 6383   1-1278 2155-2236 HODGM46 473 974051 AC002369 6384  1-586 2559-2651 3329-3426 3756-5088 HODGM46 473 974051 AC002351 6385  1-115 HODGM46 473 974051 AC002369 6386  1-228 HODGO46 474 883087 AC037489 6387  1-346 1670-2284 2466-2854 4400-4511 6053-6599 7153-7508 8502-8724  9716-10001 11982-12304 HODGO46 474 883087 AC019171 6388  1-669  797-1185 2733-2844 4386-4932 5136-5165 HODGO46 474 883087 AC037489 6389   1-1408 HODGO46 474 883087 AC037489 6390  1-175 HODGO46 474 883087 AC019171 6391  1-356 HODGO46 474 883087 AC019171 6392  1-345 HODGP37 475 974293 AC023592 6393  1-570 HODGP37 475 974293 AC069441 6394  1-570 HODGP83 476 889967 AC013723 6395  1-110 1542-2027 3382-3689 5800-5966 HODGP83 476 889967 AC009973 6396  1-74 1507-2339 3336-3657 5766-5932 HODGP83 476 889967 AC013723 6397  1-499 HODGP83 476 889967 AC013723 6398  1-314 HODGP83 476 889967 AC009973 6399  1-314 HODGP83 476 889967 AC009973 6400  1-499 HODGQ08 478 958237 AC026000 6401  1-509 HODGQ08 478 958237 AC025510 6402  1-509 HODGQ32 480 974294 AC024497 6403  1-705 HODGQ32 480 974294 AC024497 6404   1-3866 HODGQ92 481 894368 AP000751 6405  1-96 1450-1596 2035-2116 HODGQ92 481 894368 AP000751 6406  1-369 HODGT62 482 974052 AC011008 6407  1-731 HODGT62 482 974052 AC044783 6408  1-731 HODGW08 483 958277 AL121966 6409  1-562 HODGW08 483 958277 AC025054 6410  1-562 HODGW08 483 958277 AC009425 6411  1-562 HODGW08 483 958277 AL121966 6412  1-485 HODGW08 483 958277 AC025054 6413  1-409 HODGW08 483 958277 AL121966 6414  1-409 HODGW08 483 958277 AC025054 6415  1-485 HODGW08 483 958277 AC009425 6416  1-485 HODGW08 483 958277 AC009425 6417  1-409 HODGZ06 486 933783 AC007685 6418  1-452 497-619 1248-2116 2423-2493 2610-2725 3566-3716 4422-4552 6708-7287 12653-12705 12963-13427 17808-17904 HODGZ06 486 933783 AC007685 6419  1-160 HODGZ06 486 933783 AC007685 6420   1-2806 2896-4507 HODGZ10 487 961977 AC064861 6421  1-85 1146-1687 HODGZ10 487 961977 AC073838 6422  1-86 1147-1688 HODGZ10 487 961977 AC064861 6423  1-399 HODGZ10 487 961977 AC073838 6424  1-399 HODHC03 488 922987 AC009237 6425   1-1362 HODHC03 488 922987 AC009237 6426  1-720 HODHC03 488 922987 AC009237 6427  1-307 580-1408 HODHD16 489 974924 AL162431 6428  1-42  915-1065 1167-1633 2254-2484 3637-4873 HODHD16 489 974924 AC064851 6429  1-42  915-1057 1167-1633 2254-2484 3637-7666 7672-7821  7877-10024 HODHD16 489 974924 AC064851 6430  1-188 HODHD16 489 974924 AL162431 6431  1-413 1767-2068 HODHD16 489 974924 AC064851 6432  1-413 1767-2068 HODHK02 494 918613 AC009944 6433  1-301 HODHK02 494 918613 AC019299 6434  1-301 HODHK02 494 918613 AC009822 6435  1-301 HODHK02 494 918613 AC019299 6436  1-483 HODHK02 494 918613 AC009944 6437  1-483 HODHK02 494 918613 AC009822 6438  1-483 HODHL56 496 847724 AF236876 6439  1-935 HODHL56 496 847724 AC019257 6440  1-935 HODHL56 496 847724 AF236876 6441  1-493 HODHL56 496 847724 AC019257 6442  1-493 HODHO11 497 965529 AC027399 6443  1-317 HODHO11 497 965529 AC027399 6444  1-318 HODHS34 498 965460 AC022665 6445  1-532 HODHS34 498 965460 AL078646 6446  1-317  372-1502 HODHS34 498 965460 AL117349 6447  1-317  372-1502 HODHS34 498 965460 AL078646 6448  1-615 HODHS34 498 965460 AL117349 6449  1-615 HODHY53 499 914554 AC026367 6450  1-669 HODHY53 499 914554 AC027063 6451  1-669 HODJZ90 502 965049 AC009118 6452  1-155 657-767  862-1035 1706-2237 2902-3158 3800-4185 4530-4783 5286-5461 6519-6695 6845-6976 7956-8460 8578-8682 10277-10454 12772-12939 13545-13749 14101-14364 15084-15617 16693-17078 17284-17820 17893-18820 HODJZ90 502 965049 AC068659 6453  1-168 775-979 1331-1594 2315-2847 3900-4316 4491-5027 5100-7427 7603-8027 8209-8523 9220-9673 9808-9950 10065-10377 HODJZ90 502 965049 AC010287 6454  1-152 1091-1213 1460-1748 2882-3432 5178-5410 5727-5869 7099-7282 8390-8552 9319-9434 9703-9816 10255-10328 10502-10681 11511-11641 13098-13673 14293-14594 14667-14772 15383-15627 17040-17237 18114-18254 18756-18866 18961-19136 19803-20334 20999-21280 21897-22282 22627-22880 23383-23641 24623-24788 24938-25069 26048-26552 26670-26774 28368-28545 30865-31032 31639-31843 32195-32458 33179-33711 34763-35179 35354-35890 35963-38290 38466-38890 39072-39386 40083-40535 40670-40812 40927-41239 HODJZ90 502 965049 AC068659 6455  1-374 HODJZ90 502 965049 AC010287 6456  1-374 HODJZ90 502 965049 AC010287 6457  1-552 HOFAE61 509 707359 AC015841 6458  1-522  624-2029 HOFAE61 509 707359 AC015841 6459  1-454 HOFAE61 509 707359 AC015841 6460  1-146 1533-2211 2325-2545 HOFMA24 511 782275 AC027590 6461  1-150  819-1344 HOFMA24 511 782275 AC027590 6462  1-309 HOGCX95 591 890607 AC024052 6463   1-1585 HOGCX95 591 890607 AC026640 6464   1-1585 HOGCX95 591 890607 AC026640 6465  1-593 HOGCX95 591 890607 AC024052 6466  1-593 HOOJQ59 594 965013 AC011773 6467  1-112  958-1122 2276-2368 2434-2591 5326-5394 6480-6792 7058-7324 8121-8598 8781-9141 10080-10113 11282-13254 13555-13984 13987-14323 14474-14670 14730-16350 16725-16864 17843-17908 HOOJQ59 594 965013 AC011773 6468  1-268 1581-1897 4118-4159 HOVAF17 595 576627 AC010907 6469  1-430 HOVAF17 595 576627 AC010907 6470  1-131 HOVAG49 597 927320 AL355615 6471   1-1030 1130-1727 HOVAG49 597 927320 AL136082 6472   1-1030 1130-1727 HOVAG49 597 927320 AL355615 6473  1-392 HOVAG49 597 927320 AL136082 6474  1-392 HOVAI41 598 670963 AL136419 6475  1-100 HOVAI41 598 670963 AL136419 6476  1-146 HOVBQ10 601 964671 AL078474 6477  1-789 HOVBQ10 601 964671 AL078474 6478  1-284 HOVBQ10 601 964671 AL078474 6479  1-69  687-1133 2574-2676 3006-3363 3826-3975 4852-5112 5737-6317 HOVBY34 602 706816 AC006512 6480  1-247 2812-2918 3488-3953 3964-4527 4683-5151 5330-9121 9884-10335 10748-10781 10960-11055 11323-12111 12127-12791 12911-13262 13266-13791 14696-14866 15107-15207 16551-16955 17174-17614 18504-18749 19392-19660 19720-20075 20785-21233 21290-21733 23618-23649 23982-24188 24481-24573 24741-25003 26591-26705 26738-27249 28479-28858 29065-31669 31926-32887 33667-34293 35229-35682 38114-38771 HOVBY34 602 706816 AC025550 6481  1-405 HOVBY34 602 706816 AC002357 6482   1-1186 HOVBY34 602 706816 AC006512 6483  1-818  963-1440 1469-1958 2220-3076 3455-3663 3931-4285 4549-4632 4696-5069 5245-5337 5461-5775 HOVBY34 602 706816 AC006512 6484  1-738 HOVCA52 604 727170 AC025741 6485  1-696 HOVCI76 606 858845 AL049694 6486  1-469 HOVCI76 606 858845 AL049694 6487  1-476 HOVCJ24 608 858844 AC005096 6488  1-364 HOVCJ24 608 858844 AC005096 6489  1-452 HOVCJ24 608 858844 AC005096 6490  1-161 HOVCM22 609 674177 AC008636 6491   1-1708 1746-1835 2249-2976 HOVCM22 609 674177 AC008675 6492   1-1708 1746-1835 2249-2976 HOVCM22 609 674177 AC008625 6493   1-1712 1750-1839 2253-2980 HOVCM22 609 674177 AC018757 6494  1-700 HOVCM22 609 674177 AC008636 6495  1-399 HOVCM22 609 674177 AC008636 6496  1-512 HOVCM22 609 674177 AC008675 6497  1-512 HOVCM22 609 674177 AC008625 6498  1-512 HOVCM22 609 674177 AC008675 6499  1-400 HOVCM22 609 674177 AC008625 6500  1-399 HOVCM22 609 674177 AC018757 6501  1-955 HOVCO11 610 970814 AC004520 6502   1-3242 HOVCO11 610 970814 AC010677 6503   1-1724 1877-2444 2754-3600 3759-3976 4113-4236 4295-4403 4868-5153 5486-5685 5729-6209 6382-6482 6747-7765  7838-11596 HOVCO11 610 970814 AC004520 6504  1-423 HOVCO11 610 970814 AC010677 6505  1-41 3758-5500 5561-8116 8808-8972 10854-11380 13142-13690 14343-15093 15286-15643 15801-16163 HOVCO58 611 736065 AC018665 6506  1-416 HOVCQ47 612 496190 AL354979 6507   1-1421 HOVEK70 615 909138 AC016877 6508  1-369  817-2106 2511-2860 4380-5157 6201-6321 7064-7649 11036-11360 HOVEK70 615 909138 AC016877 6509  1-139 HOVJA10 617 961467 AL160290 6510  1-442 HOVJA10 617 961467 AL160290 6511  1-119 HPCAH88 622 953808 AL356212 6512  1-835 HPCAH88 622 953808 AL356212 6513   1-1422 HPCAI68 624 655536 AC026134 6514  1-354 HPCAK16 625 662121 AL139185 6515  1-716 HPCAK16 625 662121 AL139181 6516  1-135 185-285 3899-4614 4653-4942 5462-5478 HPCAK16 625 662121 AL139185 6517  1-290 HPCAK16 625 662121 AL139181 6518  1-724 HPCAK16 625 662121 AL139181 6519  1-554 HPCAK57 626 734931 AL136531 6520  1-430 HPCAK57 626 734931 AL031665 6521  1-430 HPCAK57 626 734931 AL136531 6522  1-378 HPCAK57 626 734931 AL136531 6523  1-396 HPCAK57 626 734931 AL031665 6524  1-396 HPCAK57 626 734931 AL031665 6525  1-378 HPCAL60 627 655723 AC009896 6526   1-1578 1640-1954 2042-2612 HPCAL60 627 655723 AC068429 6527  1-980 HPCAL60 627 655723 AC009896 6528  1-119 HPCAL60 627 655723 AC068429 6529  1-119 HPCAL60 627 655723 AC068429 6530   1-1030 HPCAL86 628 924709 AC073027 6531  1-307 HPCAL86 628 924709 AC026874 6532  1-307 HPCAM22 629 655607 AC002381 6533  1-421 HPCAM22 629 655607 AC002381 6534  1-746 HPCAM22 629 655607 AC002381 6535  1-357 HPCAN59 630 655742 AL358075 6536  1-295 HPCAN59 630 655742 AC053512 6537  1-295 HPCAN59 630 655742 AL358075 6538  1-430 HPCAN59 630 655742 AC053512 6539  1-430 HPCAO04 631 655732 AL390024 6540  1-664 HPCAO04 631 655732 AL160060 6541  1-663 HPCAO04 631 655732 AL390024 6542  1-320 HPCAO04 631 655732 AL160060 6543  1-320 KPCPO07 633 951826 AC010595 6544  1-512 HPCPO07 633 951826 AC021175 6545  1-512 HPDOY06 636 929318 AC024534 6546  1-472 HPDOY06 636 929318 AC068222 6547  1-670  818-1289 1297-1525 HPDOY06 636 929318 AC068222 6548  1-119 HPDOY06 636 929318 AC024534 6549  1-670 HPDPK12 638 969340 AC016737 6550  1-1302 HPDPK12 638 969340 AC016737 6551  1-241 HPDPQ40 639 922464 AC016731 6552  1-608 HPDPQ40 639 922464 AC073119 6553  1-608 HPDPQ40 639 922464 AC016731 6554  1-603 HPDRB01 641 914437 AC016032 6555  1-483 1320-3926 4782-5528 6670-6715 HPDRB01 641 914437 AC040994 6556  1-541 HPDRD28 642 957791 AL139377 6557  1-483 HPDRD28 642 957791 AL139377 6558  1-412 HPDRD28 642 957791 AL139377 6559  1-411 HPDRG92 643 967704 AC069546 6560  1-131 220-297 620-921 1555-1722 1899-2066 2727-3464 4649-5150 HPDRG92 643 967704 AC012683 6561  1-131 220-297 620-921 1555-1722 1899-2066 2727-3464 4650-5151 HPDRG92 643 967704 AC069546 6562  1-116 HPDRG92 643 967704 AC012683 6563  1-861 HPDRG92 643 967704 AC012683 6564  1-45  915-1022 HPDRO20 644 957678 AC027421 6565  1-426 HPDRO20 644 957678 AL353622 6566  1-172 180-293 2209-2873 2876-3301 4705-6461 6539-6708 HPDRO20 644 957678 AC025860 6567  1-426 HPDRO20 644 957678 AC027421 6568  1-527 HPDRO20 644 957678 AC025860 6569  1-665 HPDVF03 647 922193 AC022084 6570  1-147 388-490 560-958 1148-1479 2004-4169 HPDVF03 647 922193 AC027140 6571  1-147 388-490  560-1021 1138-1469 1993-4158 HPDVF03 647 922193 AC022084 6572  1-453 HPDVY17 650 955902 AC007009 6573  1-435 HPEAF19 651 867892 AC024132 6574  1-344 HPEBA06 652 960802 AL359892 6575  1-655 HPEBA06 652 960802 AL031777 6576  1-655 HPEBA06 652 960802 AL359892 6577  1-802 HPEBA06 652 960802 AL359892 6578  1-345 1680-2328 HPEBA06 652 960802 AL031777 6579  1-340 1677-2325 HPEBA06 652 960802 AL031777 6580  1-545 HPEBA51 653 723298 AL353788 6581  1-434 HPEBA51 653 723298 AL139184 6582  1-434 HPEBA51 653 723298 AL353788 6583  1-143 HPEBA51 653 723298 AL139184 6584  1-143 HPEBD31 654 655760 AC018761 6585  1-538 HPEBD31 654 655760 AC020934 6586  1-538 HPEBD31 654 655760 AC018761 6587  1-263 HPEBD31 654 655760 AC020934 6588  1-736 792-957 1232-1693 1845-2006 2206-2481 2621-3482 3536-3786 3815-4535 4695-5049 HPEBD31 654 655760 AC018761 6589  1-736 792-957 1232-1693 1845-2006 2206-2481 2621-3482 3548-3786 3815-4535 4695-5049 HPEBD31 654 655760 AC020934 6590  1-263 HPEKJ42 657 922391 AC078803 6591  1-384 393-809  961-1370 HPEKJ42 657 922391 AC069418 6592  1-384 393-809  961-1370 HPEKJ42 657 922391 AC078803 6593  1-167 HPEKJ42 657 922391 AC069418 6594  1-167 HPEKJ42 657 922391 AC078803 6595  1-262 HPEKJ42 657 922391 AC069418 6596  1-262 HPEKU27 658 921663 AC011939 6597  1-647 HPEKU27 658 921663 AC011939 6598  1-313 HPFAA06 660 960801 AC004111 6599  1-863 3429-4124 HPFAA06 660 960801 AC010277 6600  1-863 3424-4119 HPFAA06 660 960801 AC004111 6601  1-667 HPFAA06 660 960801 AC004111 6602  1-522 HPFAA06 660 960801 AC010277 6603  1-667 HPFAA06 660 960801 AC010277 6604  1-401 HPFCA36 661 524720 AC007065 6605  1-340 351-738 1335-1773 3899-4267 14595-14825 18322-18557 19664-20128 20663-20915 22067-22299 HPFCA36 661 524720 AC007065 6606  1-495 HPFCA36 661 524720 AC007065 6607  1-483 HPFCA71 662 655596 AC018681 6608  1-364 HPFCF09 663 536666 AC022417 6609  1-174 1973-2115 2563-3003 3442-3591 4140-4231 5955-6389 6564-7100 8645-8708 8978-9101 10914-11290 11985-12297 13345-13410 14962-15695 18991-19133 20469-22756 HPFCF09 663 536666 AC022417 6610  1-104 HPFCF24 664 655744 AL160279 6611  1-398 HPFCF24 664 655744 AL160279 6612  1-313 HPFCF83 666 781490 AC036220 6613  1-327 HPFCF83 666 781490 AC026273 6614  1-327 HPFCF83 666 781490 AC018963 6615  1-369 HPFCF83 666 781490 AC023099 6616  1-369  627-1264 1708-2248 HPFCF83 666 781490 AC016424 6617  1-393 HPFCF83 666 781490 AC008776 6618  1-369 HPFCF83 666 781490 AC022264 6619  1-369  627-1264 1708-2248 HPFCF83 666 781490 AC024972 6620  1-390 HPFCF83 666 781490 AC036220 6621   1-1419 HPFCF83 666 781490 AC026273 6622   1-1420 HPFCF83 666 781490 AC023099 6623   1-1529 HPFCF83 666 781490 AC016424 6624  1-612 HPFCF83 666 781490 AC008776 6625  1-339 4826-4859 HPFCF83 666 781490 AC018963 6626   1-1382 1384-1518 HPFCF83 666 781490 AC023099 6627  1-434 HPFCF83 666 781490 AC016424 6628   1-1527 HPFCF83 666 781490 AC022264 6629   1-1529 HPFCF83 666 781490 AC022264 6630  1-434 HPFCF83 666 781490 AC024972 6631   1-1524 HPFCF83 666 781490 AC024972 6632  1-612 HPFCH15 667 655768 AC068428 6633  1-352 HPFCH89 668 655538 AC012589 6634  1-227 HPFCH89 668 655538 AC022088 6635  1-227 HPFCH89 668 655538 AC012589 6636  1-250 HPFCH89 668 655538 AC022088 6637  1-250 HPFCM41 669 655736 AC008278 6638  1-348 HPFCM41 669 655736 AC008271 6639  1-348 HPFCM41 669 655736 AC008278 6640  1-471 HPFCM41 669 655736 AC008271 6641  1-471 HPFCM87 670 925495 AC004479 6642  1-318 HPFCM87 670 925495 AC004480 6643  1-318 HPFCM87 670 925495 AC004479 6644  1-155 HPFCM87 670 925495 AC004480 6645  1-155 HPFCO02 672 867871 AC019103 6646   1-1224 HPFCO67 673 867880 AC024489 6647  1-302 HPFCR21 675 655621 AC066603 6648  1-448 HPFCR21 675 655621 AC066603 6649  1-326 HPFCT53 678 974257 AC078894 6650  1-654 HPFCT53 678 974257 AC026815 6651  1-654 HPFCT53 678 974257 AC034258 6652  1-648 HPFCT53 678 974257 AC078893 6653  1-640 HPFCT53 678 974257 AC068667 6654  1-654 HPFCT53 678 974257 AC073166 6655  1-640 HPFCT53 678 974257 AC074226 6656  1-640 HPFCT53 678 974257 AC027037 6657  1-640 HPFCT53 678 974257 AC078898 6658  1-640 HPFCT53 678 974257 AC068924 6659  1-640 HPFCT62 679 655432 AC016767 6660  1-689 HPFCT62 679 655432 AC026369 6661  1-689 HPFCT62 679 655432 AL078621 6662  1-689 HPFCT62 679 655432 AC016767 6663  1-653 HPFCT62 679 655432 AC026369 6664  1-104 117-884  890-1137 HPFCT62 679 655432 AL078621 6665   1-1121 HPFCV71 681 525554 AL133410 6666  1-957 1117-1339 1594-1735 2021-2186 2430-2526 2791-2922 3026-3179 3416-3562 3669-3799 3855-4635 4830-4891 5448-6268 6357-7105 HPFCV71 681 525554 AL133410 6667  1-189 HPFCV71 681 525554 AL133410 6668  1-85 1082-1951 2761-3118 HPFCX18 682 655588 AC022598 6669  1-559 HPFCX18 682 655588 AC024367 6670  1-559 HPFCX18 682 655588 AC022598 6671  1-484 539-645 HPFCX18 682 655588 AC022598 6672  1-421 HPFCX18 682 655588 AC024367 6673  1-421 HPFCX18 682 655588 AC024367 6674  1-484 539-645 HPFDD06 683 960700 AL359314 6675  1-282 HPFDD06 683 960700 AL390239 6676  1-418 HPFDD06 683 960700 AL390239 6677  1-157  634-1162 HPFDE38 684 655704 AC073616 6678  1-615 HPFDE38 684 655704 AC061966 6679  1-615 HPFDE38 684 655704 AC061966 6680  1-957 HPFDE38 684 655704 AC061966 6681  1-396 HPFDF79 686 973732 AL139240 6682  1-600 HPFDF79 686 973732 AL139240 6683  1-497 HPFDG58 687 655610 AC021557 6684  1-358 HPFDG58 687 655610 AC021557 6685  1-308 HPFDI23 688 655549 AC044876 6686  1-351 HPFDI23 688 655549 AC010983 6687  1-351 HPFDI23 688 655549 AC010983 6688   1-1694 HPFDL90 689 954333 U73330 6689  1-204 HPFDL90 689 954333 AL137143 6690  1-204 HPFDL90 689 954333 AL137143 6691  1-114 HPFDS59 690 655543 AC004111 6692  1-279 HPFDS59 690 655543 AC004111 6693  1-429 HPFDT17 691 581133 AC021972 6694  1-360 HPFDT17 691 581133 AC023961 6695  1-360 HPFDT17 691 581133 AC023961 6696  1-493 HPFDT54 692 655530 AC078787 6697  1-337 HPFDT54 692 655530 AC068844 6698  1-337 HPFDT54 692 655530 AC068844 6699  1-156 307-357 HPFDT61 693 974569 AC012456 6700  1-429 HPFDT61 693 974569 AC012456 6701  1-508 HPFDU30 694 522113 AL079301 6702  1-353 HPFDU30 694 522113 AL079301 6703  1-368 HPFDU30 694 522113 AL079301 6704  1-477 HPFDU38 695 867879 AP001816 6705  1-357 HPFDU38 695 867879 AC013785 6706  1-357 HPFDU38 695 867879 AP001816 6707   1-1082 HPFDU38 695 867879 AP001816 6708  1-605 HPFDU38 695 867879 AC013785 6709   1-1082 HPFDU38 695 867879 AC013785 6710  1-605 HPFDV71 697 867870 AC004170 6711  1-90 HPFDV71 697 867870 AC004170 6712  1-498  742-1013 1596-1878 2017-2131 2550-3098 HPFDX13 698 655571 AC015499 6713  1-163  842-1416 1593-1862 2203-2279 3755-4525 4585-5183 5285-5721 HPFDX13 698 655571 AC034139 6714  1-163  842-1416 1593-1862 2203-2279 3755-4525 4585-5183 5285-5721 HPFDX13 698 655571 AC015499 6715  1-274 HPFDX13 698 655571 AC034139 6716  1-250  370-1118 HPFDX13 698 655571 AC034139 6717  1-195 HPFDZ20 699 655764 AC026262 6718  1-320 HPFDZ20 699 655764 AC026262 6719  1-145 HPFDZ20 699 655764 AC026262 6720  1-394 HPFEA08 700 960372 AL158145 6721  1-102 605-988  994-1149 1496-1658 1689-2232 2888-3316 4118-5228 5538-5638 8075-8374 9151-9248 10537-10628 14985-15054 HPFEA08 700 960372 AL158145 6722  1-101 HPFEA32 701 925499 AF228661 6723  1-296 HPFEA32 701 925499 AF215845 6724  1-296 HPIAE79 704 655748 AC011234 6725  1-367 HPIAQ49 706 919469 AL161913 6726  1-434 HPIAQ49 706 919469 AC007951 6727  1-434 HPIAS40 708 928614 AC005606 6728  1-237  839-1786 1974-2464 HPIAS40 708 928614 AC005363 6729  1-237  839-1786 1974-2464 HPIAS40 708 928614 AC005606 6730  1-517 HPIAS40 708 928614 AC005606 6731   1-1306 1548-1968 2231-2776 HPIAS40 708 928614 AC005363 6732  1-517 HPIAS40 708 928614 AC005363 6733   1-1306 1548-1968 2231-2776 HPTAV80 709 615007 AC011747 6734  1-316 562-618  724-1313 1814-2395 HPJAV80 709 615007 AC012495 6735  1-316 562-618  724-1313 1814-2395 HPJAV80 709 615007 AC011747 6736   1-1776 HPJAV80 709 615007 AC012495 6737  1-133 239-638 2245-2345 3320-3556 5015-8143 HPIAZ37 711 655753 AC018613 6738  1-357 1494-1815 2463-5309 5330-8041 HPJAZ37 711 655753 AL356099 6739  1-357 1495-1816 2464-5308 5330-8041 16792-21577 HPIAZ37 711 655753 AL355474 6740  1-357 1494-1815 2463-5308 5329-8041 HPIBT49 714 655719 AC068558 6741  1-468 HPJAB19 717 655540 AC027164 6742  1-422 HPJAB19 717 655540 AC024388 6743  1-422 HPJAB19 717 655540 AC027164 6744  1-325 HPJAB19 717 655540 AC024388 6745  1-325 HPJAB84 718 655531 AC013471 6746  1-335 HPJAC36 719 655601 AC073476 6747  1-107 2096-2450 3106-3182 3643-3787 4316-4982 5399-5724 6657-7075 7479-7686 9286-9495 9701-9784 10235-10339 HPJAC92 720 867831 AP001374 6748  1-441 HPJAC92 720 867831 AP001845 6749  1-441 HPJAC92 720 867831 AP001374 6750  1-370 HPJAC92 720 867831 AP001845 6751  1-370 HPJAD09 721 655712 AL356873 6752  1-341 HPJAD09 721 655712 AL080239 6753  1-341 HPJAD66 722 655694 Z83851 6754  1-375 HPJAD82 723 655765 AC023550 6755  1-599 HPJAD82 723 655765 AC078819 6756  1-599 HPJAD82 723 655765 AC023550 6757  1-262 HPJAD82 723 655765 AC078819 6758  1-180 HPJAD82 723 655765 AC023550 6759  1-180 HPJAD82 723 655765 AC078819 6760  1-262 HPJAV07 724 952852 AC022990 6761  1-330 HPJAV07 724 952852 AC022990 6762  1-338 HPJAW56 725 823393 AL133367 6763  1-165  783-1556 1977-2558 2777-3332 5836-5901 6380-6716 8410-8804 8835-9058 9117-9251 9256-9300 11060-11133 11732-12384 12444-12715 13449-13561 13987-14379 14896-15192 15858-15966 16321-16773 18398-18513 19468-19712 19813-20395 20559-20943 20993-22107 22393-22611 24662-24850 24956-25724 25847-26145 28326-28682 31448-31886 32028-32113 35668-35923 36174-36274 36661-36791 37689-37782 38775-39150 41192-41636 41806-41916 42383-42524 42541-45950 47201-47609 47660-48144 50495-50598 50986-51806 52416-52442 52518-52822 53922-54114 54796-54941 55169-55725 55755-56418 56558-57751 KPJAW56 725 823393 AL133367 6764  1-115 HPJAW56 725 823393 AL133367 6765  1-324 HPJBI17 726 655761 AC018493 6766  1-433 HPJBI17 726 655761 AC018840 6767  1-433 HPJBI17 726 655761 AC011327 6768  1-433 HPJBI17 726 655761 AC023514 6769  1-433 HPJBI17 726 655761 AC018493 6770   1-4779 HPJBI17 726 655761 AC018840 6771   1-4959 7250-7380 HPJBI17 726 655761 AC011327 6772   1-4926 7254-7384 HPJBI17 726 655761 AC023514 6773  1-559 HPJBI89 727 655708 AC006071 6774  1-97 806-944 2874-2923 3012-3124 4930-5376 7132-7248 8149-8301 11085-11487 12690-12774 13247-13392 HPJBI89 727 655708 AC002092 6775  1-50 768-905 2835-2884 2973-3083 4894-5636 7096-7212 8116-8253 HPJBI89 727 655708 AC006071 6776  1-676 HPJBK52 728 655751 AC026458 6777  1-635 HPJBK52 728 655751 AC026957 6778  1-519 HPJBK52 728 655751 AC068974 6779  1-638 HPJBK52 728 655751 AC022770 6780  1-638 HPJBK52 728 655751 AF271408 6781  1-519 HPJBK52 728 655751 AC000378 6782  1-636 HPJBK52 728 655751 AF165177 6783  1-637 HPJBK52 728 655751 AF284563 6784  1-438 HPJBK52 728 655751 AC026957 6785   1-1148 HPJBK52 728 655751 AC068974 6786  1-170 HPJBK52 728 655751 AC068974 6787  1-674 HPJBK52 728 655751 AC022770 6788  1-632 HPJBK52 728 655751 AF271408 6789  1-512 HPJBK52 728 655751 AC000378 6790  1-336 HPJBK52 728 655751 AE165177 6791  1-666 HPJBK52 728 655751 AE284563 6792  1-672 HPJBU08 729 958979 AC034223 6793  1-365 HPJBU08 729 958979 AC025459 6794  1-365 HPJBU08 729 958979 AC034223 6795  1-470 HPJBU08 729 958979 AC025459 6796  1-470 HPJBV17 730 655729 AC007394 6797  1-300 HPJCC04 731 926787 AC020746 6798  1-402 HPJCC04 731 926787 AC020746 6799  1-137  996-1100 HPJCC04 731 926787 AC020746 6800  1-305 HPJCP10 732 964259 AC010384 6801  1-482 HPJCP10 732 964259 AC010471 6802  1-482 HPJCP10 732 964259 AL161724 6803  1-482 HPJCP11 733 966676 AC027746 6804  1-338 HPJCP11 733 966676 AC007962 6805   1-2776 HPJCP11 733 966676 AC007962 6806  1-912 HPJCV50 735 968095 AC024179 6807  1-560 HPJCV50 735 968095 AC005923 6808  1-37  647-1206 1576-1798 HPJCV50 735 968095 AC024179 6809  1-721 HPJCV50 735 968095 AC005923 6810  1-749 HPJCV50 735 968095 AC005923 6811  1-57 649-810  915-1002 HPJCX26 737 655600 AL354668 6812  1-350 HPJCY70 738 655569 AC073576 6813  1-378 HPJCY70 738 655569 AL355916 6814  1-378 HPJCZ03 739 922850 AC019301 6815  1-322 HPJCZ03 739 922850 AC019301 6816  1-115 HPJCZ03 739 922850 AC019301 6817  1-117 HPJCZ06 740 934170 AC012101 6818  1-434 HPJCZ06 740 934170 AC012101 6819  1-261 HPJDX94 744 838748 AC027752 6820  1-385 HPJDX94 744 838748 AC024033 6821  1-385 HPJEE38 745 954970 AC013693 6822   1-1366 2356-2591 2984-3479 3997-4331 4805-5239 6918-7038 7281-7378 7510-7940 8150-8312 8749-8898 8979-9407 HPJEI55 746 926815 AC012141 6823  1-464 HPJEI55 746 926815 AL138843 6824  1-464 HPJEI55 746 926815 AL138787 6825  1-464 HPJEI55 746 926815 AC012141 6826  1-643 HPJEI55 746 926815 AL138843 6827  1-206 2313-2650 3456-4431 HPJEI55 746 926815 AC012141 6828  1-976 HPJEI55 746 926815 AL138843 6829  1-643 HPJEI55 746 926815 AL138787 6830  1-206 2313-2650 3456-4433 HPJEI55 746 926815 AL138787 6831  1-643 HPJEJ39 747 930988 AL162551 6832  1-605 HPJEJ39 747 930988 AL121576 6833  1-605 HPJEQ22 749 867725 AC021715 6834  1-639 HPJEQ22 749 867725 AL163052 6835  1-639 HPJEV06 751 934096 AP000773 6836  1-769 HPJEV06 751 934096 AC018708 6837  1-768 HPJEV06 751 934096 AC011207 6838  1-768 HPJEV06 751 934096 AP000773 6839  1-495 909-997 1276-1446 HPJEV06 751 934096 AC018708 6840  1-409 HPJEV06 751 934096 AP000773 6841  1-409 HPJEV06 751 934096 AC018708 6842  1-495 909-997 1276-1446 HPJEV06 751 934096 AC011207 6843  1-409 HPJEV06 751 934096 AC011207 6844  1-495 909-997 1276-1446 HPLAR41 753 557554 AC025660 6845  1-878 932-1290 1376-4492 HPLAR41 753 557554 AC025660 6846  1-378 HPLBB50 754 503751 AC063933 6847  1-352 HPLBB50 754 503751 AC063933 6848  1-129 HPLBL31 755 503732 AC025504 6849  1-95 214-573 1821-2446 2525-3036 3115-3492 HPLBL31 755 503732 AL139138 6850  1-807 2652-2751 2986-3064 4764-4858 4976-5335 6582-7207 7300-7599 HPLBL57 756 503730 AC026812 6851  1-273 HPLBL57 756 503730 AC002427 6852  1-273 HPLBO61 757 558187 AC004604 6853   1-1105 HPLBO61 757 558187 AC004555 6854   1-3035 3284-3602 4172-4261 4501-5491 8136-8894 9100-9670 10426-10533 HPLBO61 757 558187 AC004555 6855  1-241 HPMBK34 760 954057 AC067815 6856  1-784 HPMBK34 760 954057 AC005940 6857  1-784 HPMBK34 760 954057 AC067815 6858   1-2349 HPMBK34 760 954057 AC005940 6859   1-2349 HPMBK34 760 954057 AC005940 6860   1-1408 HPMBK49 761 577661 AC032007 6861   1-1545 HPMBK49 761 577661 AC032007 6862  1-350 HPMBK49 761 577661 AC032007 6863  1-756 HPMBU81 767 557870 AL356789 6864  1-490 HPMBU81 767 557870 AL357313 6865  1-491 HPMBU81 767 557870 AL356789 6866  1-298 HPMBU81 767 557870 AL357313 6867  1-475 HPMBX35 768 531058 AC025273 6868  1-202 641-759 1106-1412 2149-2340 3181-3506 3552-3829 4051-4415 5783-6248 7556-8169 10620-10984 11384-11500 11517-11876 12821-12929 14588-14653 15115-15821 18702-18895 21135-21421 23417-24021 26437-26746 26819-26923 29864-30165 30638-31071 31388-31737 32445-32589 33347-33643 33675-34651 34798-35053 35667-36376 HLPMBX35 768 531058 AC008915 6869  1-466 1774-2387 4838-5202 5602-5718 5735-6094 7039-7201 8806-8871  9333-10039 12900-13093 15330-15616 17613-18217 20634-20943 21016-21120 24061-24362 24833-25267 25584-25933 26641-26785 27543-27839 27871-28847 28994-29249 29863-30573 HPMBY83 771 527006 AC011200 6870  1-433 HPMBY83 771 527006 AC011618 6871  1-433 HPMBY83 771 527006 AC011200 6872   1-1097 HPMBY83 771 527006 AC011200 6873  1-105 HPMBY83 771 527006 AC011618 6874  1-278 HPMCB65 773 531289 AL354833 6875  1-316  564-1413 1607-1800 2119-2419 3091-4057 4252-4680 7398-7790 8083-8259 8450-8642  9096-11423 11866-13435 HPMCB65 773 531289 AL354833 6876  1-121 HPMCC73 774 531066 AC023287 6877   1-1159 HPMCC73 774 531066 AC012118 6878   1-1128 HPMCC73 774 531066 AC023287 6879  1-422 HPMCC73 774 531066 AC012118 6880  1-422 HPMCJ14 778 524768 AL031591 6881  1-403 HPMCJ14 778 524768 AC000105 6882  1-403 HPMCJ14 778 524768 AC004032 6883  1-403 HPMCJ19 779 531279 AC026226 6884  1-344 HPMCJ19 779 531279 AC026392 6885  1-242 HPMCJ48 780 577601 AL158821 6886  1-324 HPMCK65 781 742095 AL023807 6887  1-607 627-906 1769-2194 HPMCK65 781 742095 AL023807 6888  1-251 HPMCK65 781 742095 AL023807 6889  1-331 HPMCS65 783 961250 AC024179 6890  1-84 1500-1981 2066-2205 3722-3803 3983-4228 4311-4461 4734-4797 5290-5391 5475-5582 5743-5809 6736-6830 6910-7020 7399-7656 7668-8575 8766-8820 9097-9235 9337-9733 HPMCS65 783 961250 AC005923 6891  1-84 1500-1981 2067-2206 2587-2955 3726-3807 3987-4231 4314-4464 4737-4800 5293-5394 5478-5585 5746-5812 6740-6834 6914-7024 7404-7661 7673-8580 8771-8825 9102-9240 9342-9738 HPMCS65 783 961250 AC005923 6892  1-163 669-841 1063-1188 1281-1537 1717-1896 2103-2213 2634-2715 3253-3377 3848-3964 4045-4195 4444-4664 4920-5082 5400-5604 6369-7256 8698-10467 HPMCW53 786 727392 AC027281 6893  1-549 HPMCW53 786 727392 AC027281 6894  1-98 HPMCW53 786 727392 AC027281 6895  1-471 HPMCY35 790 571411 AC008265 6896   1-1277 HPMCY35 790 571411 AC013429 6897   1-1277 HPMCY35 790 571411 AC008265 6898  1-838 HPMCY35 790 571411 AC008265 6899  1-308 HPMCY35 790 571411 AC013429 6900  1-303 HPMCY35 790 571411 AC013429 6901  1-838 HPMDJ09 791 582594 AC007378 6902  1-437 HPMDJ09 791 582594 AC007378 6903  1-416 HPMDL78 792 577590 AC023015 6904  1-417 HPMDL78 792 577590 AL162505 6905  1-645  747-1164 2179-2511 3184-3519 4234-4475 4615-4830 4894-5310 6227-6832 6887-6920 7700-7958 8747-8978 9761-9969 HPMDL78 792 577590 AL355392 6906  1-645  747-1164 2180-2512 3185-3520 4235-4476 4616-4831 4895-5228 6228-6833 6888-6921 7701-7959 8748-8979 9762-9970 12013-12114 14227-14369 14379-14518 15453-15685 16116-16381 21268-21424 22341-22479 22922-23004 23493-23659 23843-24090 27959-28266 30963-31074 35359-35938 HPMDL78 792 577590 AC023015 6907  1-649  751-1168 2183-2515 3188-3523 4345-4479 4628-4786 HPMDL78 792 577590 AL162505 6908  1-426 HPMDL78 792 577590 AL355392 6909  1-426 HPMDL78 792 577590 AL355392 6910  1-485 HPMDO39 793 531275 AC064796 6911  1-299 HPMDO39 793 531275 AC064796 6912  1-321 HPMDO39 793 531275 AC064796 6913  1-334 HPMDT91 795 745346 AL136332 6914  1-116 244-618 1399-1481 2637-2724 2842-2957 3010-3244 3302-3740 3879-4367 4407-4484 4783-5307 5981-6056 6472-6806 6903-7024 7110-7225 7843-8458 8924-9255 10786-10887 12006-12616 13979-15061 HPMDT91 795 745346 AL136332 6915  1-140 HPMDU19 796 577626 AC005281 6916  1-276  835-5981 5998-8928 HPMDU19 796 577626 AC005281 6917  1-529 HPMDZ62 798 531276 AL157392 6918  1-371 HPMEB66 799 531349 AL139145 6919  1-406 HPMEB66 799 531349 AC006S00 6920  1-406 HPMEB66 799 531349 AL139145 6921  1-891 HPMEB66 799 531349 AC006S00 6922  1-891 HPMEC16 800 867658 AC068884 6923  1-309 HPMEC16 800 867658 AC016772 6924  1-306 HPMEC16 800 867658 AC068884 6925  1-325 HPMEC16 800 867658 AC068884 6926  1-608 1128-1552 HPMEC16 800 867658 AC016772 6927  1-325 HPMEC36 801 668897 AC016526 6928  1-870 HPMEC36 801 668897 AC016526 6929  1-586 HPMEC69 802 702501 AC012513 6930  1-424  586-1132 1352-1892 2036-2445 HPMEC69 802 702501 AC008123 6931  1-424  586-1132 1352-1892 2036-2445 HPMEC69 802 702501 AC009521 6932  1-424  586-1132 1352-1892 2036-2445 HPMEC69 802 702501 AC012513 6933  1-324 HPMEC69 802 702501 AC012513 6934  1-148 HPMEC69 802 702501 AC008123 6935  1-324 HPMEC69 802 702501 AC008123 6936  1-148 HPMEC69 802 702501 AC009521 6937  1-324 HPMEC69 802 702501 AC009521 6938  1-148 HPMED52 803 531347 AC005004 6939   1-1352 HPMED52 803 531347 AC005004 6940  1-184 HPMED52 803 531347 AC005004 6941  1-149 HPMFB28 809 575934 AC010446 6942  1-329 HPMFB37 810 575620 AC018900 6943  1-70 504-564 2078-2335 2559-3145 4386-4975 5038-5201 5354-6773 HPMFB37 810 575620 AC013334 6944  1-70 500-560 2071-2328 2552-3138 4380-4969 5032-5195 5348-6767 HPMFB37 810 575620 AC018900 6945   1-1338 HPMFB37 810 575620 AC013334 6946   1-1340 HPMFB37 810 575620 AC018900 6947  1-65 175-275 505-590 1039-1164 1861-1949 2695-2914 3021-3150 3483-3638 3728-4338 HPMFB37 810 575620 AC013334 6948  1-111 444-599  689-1288 HPMFB75 811 526594 AC021754 6949  1-657  732-1324 1332-1738 1760-1883 2721-2831 2913-3037 4456-4576 4601-5008 5171-5281 HPMFB75 811 526594 AC021754 6950  1-352 HPMFE60 814 577636 AL139005 6951  1-431 HPMFJ55 818 577588 AC026634 6952  1-457 HPMFJ55 818 577588 AC026634 6953  1-884 HPMFL08 819 959569 Z93016 6954  1-477 HPMFL08 819 959569 Z93016 6955  1-650 HPMFL80 820 874359 AC004841 6956   1-2013 2041-2324 2337-2413 3586-3800 3839-4574 4894-5336 5361-5776 5997-6491 6570-6838 7577-7687 7777-8676 9682-9806  9879-10148 11341-11493 13101-13238 15431-15566 15940-16011 16119-16181 HPMFL80 820 874359 AC004841 6957  1-561 HPMFL80 820 874359 AC004841 6958  1-356 HPMFM29 821 582595 AC026558 6959   1-1062 HPMFM29 821 582595 AC023973 6960   1-1062 HPMFM29 821 582595 AC026558 6961   1-1331 HPMFM29 821 582595 AC023973 6962  1-127 HPMFM29 821 582595 AC023973 6963   1-1332 HPMFP30 824 577629 AC008072 6964  1-322 HPMFP30 824 577629 AC008072 6965  1-258 HPMFP38 825 575914 AC006121 6966  1-76 283-455 1081-2096 2241-2468 3824-3881 4776-4998 5882-6048 7438-7572 8605-8867 8905-9483 9616-9748 10809-11421 12429-12580 12991-13310 14224-14404 15332-16217 18288-18453 18666-19007 19613-20374 20936-21073 21639-22085 22088-22332 22816-22950 24715-24977 25733-26161 26930-27124 27348-27453 28458-28682 28764-28863 31423-31717 32555-32715 32956-33127 33269-33545 33919-34319 36103-38140 HPMFP38 825 575914 AL109797 6967  1-76 283-455 1081-2096 2241-2468 2777-2914 3824-3881 4776-4998 5882-6048 7438-7572 8605-8867 8905-9483 9614-9744 10810-11422 12430-12580 12992-13311 14225-14405 15333-16218 18289-18454 18667-19008 19614-20375 20937-21074 21640-22086 22089-22333 22817-22951 25734-26162 26931-27125 27349-27454 28228-28352 28459-28683 28765-28864 31425-31718 32476-32792 32957-33128 33270-33546 33920-34321 35214-35796 36099-38136 HPMFP38 825 575914 AL109797 6968  1-108 HPMFP38 825 575914 AL109797 6969  1-112 HPMFS41 827 711640 Z95331 6970  1-438 HPMES41 827 711640 Z95331 6971  1-83 HPMFT04 828 916662 AC016813 6972  1-324 HPMFT04 828 916662 AC016813 6973  1-213 HPMFU89 829 575894 AC022210 6974  1-350 HPMFU89 829 575894 AC022210 6975  1-17 420-840 1098-1343 HPMFV82 831 575911 AL160231 6976  1-560 HPMFV82 831 575911 AL160231 6977  1-708 HPMFV82 831 575911 AL160231 6978  1-521 HPMFW78 834 932529 AC012221 6979  1-535 HPMFW78 834 932529 AC012221 6980  1-617 HPMFX13 835 575908 AL050350 6981   1-1168 HPMFX13 835 575908 AL050350 6982  1-100 HPMFX65 836 867657 AL031282 6983  1-384 HPMFX65 836 867657 AL031282 6984  1-338 HPMFX65 836 867657 AL031282 6985  1-106 HPMFX70 837 577642 AL355303 6986  1-194 314-437 554-905 1348-2897 HPMFX70 837 577642 AC005383 6987  1-207 626-768 1716-1898 2187-2745 5326-5413 7250-7333 7857-7962 10837-11049 13284-13428 14141-14415 14983-15389 15403-15573 15659-16177 16352-16519 18351-18547 18667-18797 18907-19257 19618-20898 21036-22585 HPMFX70 837 577642 AL355303 6988  1-534 HPMFX70 837 577642 AC005383 6989  1-534 HPMGC23 842 703835 AC020907 6990  1-135  159-1252 1476-1903 2786-3156 4700-5283 6295-6413 7252-7356 7441-7616 7703-7789 HPMGC23 842 703835 AC020907 6991  1-201 HPMGE31 843 867648 AC009032 6992  1-426 HPMGE31 843 867648 AC010537 6993  1-424 HPMGE31 843 867648 AC009032 6994  1-99 HPMGE31 843 867648 AC009032 6995  1-233 HPMGE31 843 867648 AC010537 6996  1-162 HPMGE95 844 873392 AC018523 6997   1-1418 1445-3328 HPMGE95 844 873392 AC018523 6998  1-336 HPMGE95 844 873392 AC018523 6999   1-2444 2484-2659 2757-3196 HPMGF32 846 577615 AC006960 7000  1-349 HPMGF32 846 577615 AC008266 7001  1-351 HPMGH16 847 577641 AC026354 7002  1-412 HPMGH16 847 577641 AC060225 7003  1-412 HPMGH16 847 577641 AC060225 7004  1-67 2876-4493 HPMGH16 847 577641 AC026354 7005   1-1619 HPMGJ93 850 864040 AC024452 7006  1-340 HPMGJ93 850 864040 AC024452 7007  1-201 HPMGJ93 850 864040 AC024452 7008  1-184  727-1343 HPMGK37 851 575924 AC018458 7009  1-432 HPMGK37 851 575924 AC026202 7010  1-432 HPMGK37 851 575924 AC026164 7011  1-432 HPMGK37 851 575924 AC018821 7012  1-432 HPMGK37 851 575924 AC026202 7013  1-602 HPMGK37 851 575924 AC026164 7014  1-602 HPMGK37 851 575924 AC018821 7015  1-602 HPMGM33 854 854081 AL139128 7016   1-1034 1667-4615 HPMGM33 854 854081 AL355388 7017  1-79 566-783  904-1201 4573-4703 5038-5120 5447-5492 5543-5733 7057-8087 8125-8544 8570-8782 9084-9384 10191-10361 10724-10789 11224-11492 12498-12550 12578-13870 13968-14197 15423-15860 16293-16606 16737-17790 18448-18541 18829-21371 HPMGM33 854 854081 AL356483 7018   1-1035 1668-4614 HPMGM33 854 854081 AL139128 7019  1-314 HPMGM33 854 854081 AL355388 7020  1-154 482-945 HPMGM33 854 854081 AL356483 7021  1-156 459-950  984-1425 1512-2292 2727-2831 2935-3193 3462-3591 3910-4153 5779-6160 6294-6711 6899-7110 7935-8034 8100-8383 9023-9448 10580-11838 HPMGM33 854 854081 AL355388 7022  1-439 HPMGM33 854 854081 AL356483 7023  1-314 HPMGS09 857 575951 AL136104 7024  1-124 HPMGS09 857 575951 AL136104 7025   1-1395 HPMGS09 857 575951 AL136104 7026   1-1459 1662-2293 2447-2939 HPMGT67 859 970815 AC026510 7027  1-472 HPMGT67 859 970815 AC011475 7028  1-282 1124-1308 1546-1804 1827-2190 2230-2278 2928-3041 3534-3792 5844-6161 8497-8748 9331-9380 10799-10874 10999-11084 12851-12954 13819-14099 14137-14220 14349-14465 14554-14614 14705-14829 14948-15030 15120-15236 15511-15622 17054-17141 17265-17558 17590-18154 18240-18344 18509-18594 19012-19140 19156-19666 19732-19835 20721-20826 20934-21008 21073-21555 22855-22984 23820-24828 24885-24945 25448-25538 25979-27641 29246-29604 30552-30715 33941-34095 34383-34495 HPMGT67 859 970815 AC011475 7029   1-1999 HPMGT67 859 970815 AC011475 7030  1-302 HPMGV12 860 968364 AL355172 7031  1-294 HPMGV12 860 968364 AL139117 7032  1-351 HPMGV12 860 968364 AC009892 7033  1-351 HPMGV12 860 968364 AL139117 7034  1-294 RPMGV12 860 968364 AC009892 7035  1-294 HPMGV15 861 582596 AC025175 7036  1-269 HPMGV15 861 582596 AC008792 7037  1-269 HPMGV15 861 582596 AC024571 7038  1-269 HPMGV15 861 582596 AC025175 7039  1-191 HPMGV15 861 582596 AC024571 7040  1-276 HPMHA80 865 970813 AC010097 7041   1-3752 HPMHA80 865 970813 AL162633 7042   1-3615 HPMHA80 865 970813 AL355073 7043  1-393  610-3614 HPMHA80 865 970813 AC010097 7044  1-813 HPMHA80 865 970813 AL162633 7045  1-303 HPMHA80 865 970813 AL355073 7046  1-812 HPMHA80 865 970813 AL162633 7047  1-813 HPMHA80 865 970813 AL355073 7048  1-303 HPMHC74 868 577631 AL020990 7049  1-111 8823-9073 9156-9257 9325-9625 10063-10160 11212-11268 12867-12926 14379-14996 15086-15475 16330-16435 22187-22316 22890-22955 23988-24998 27029-27304 42968-43219 HPMHC74 868 577631 AL020990 7050  1-102 HPMHC74 868 577631 AL020990 7051  1-95 HPMHD66 869 928433 AL138976 7052  1-963 HPMHD66 869 928433 AL161669 7053  1-963 HPMHD66 869 928433 AL138976 7054  1-188 HPMHD66 869 928433 AL161669 7055  1-407 HPMJC01 871 914759 AC005484 7056  1-304 HPMJC01 871 914759 AC005484 7057   1-1308 HPMJC01 871 914759 AC005484 7058  1-615 HPMJC05 872 930844 AC006977 7059  1-442 HPMJC05 872 930844 AC006977 7060  1-832  960-1178 1319-1872 HPMJD88 873 930806 AC023991 7061  1-808 HPMJD88 873 930806 AC023991 7062  1-450 HPMJF76 875 965642 AC022895 7063  1-540 HPMJI81 876 930873 AC024077 7064  1-186 1433-2325 2647-2920 3296-3891 3988-4080 4970-5592 5628-5875 7059-7342 7610-9228  9250-10341 10502-13042 13065-13884 13886-14217 14240-15236 15301-15756 16091-16176 16422-17010 17039-17874 18020-18491 18833-19353 19410-19966 21020-21557 22200-22259 HPMJI81 876 930873 AC005392 7065  1-348  659-2096 2271-2669 2824-3667 3888-4178 4322-5035 5652-6162 6409-6997 7026-7710 8011-8481 HPMJI81 876 930873 AC005337 7066  1-110  275-3654 3656-3945 4101-5543 5862-5946 6198-6781 6815-7548 7784-8246 HPMJI81 876 930873 AC004603 7067  1-353  499-1948 2094-3422 5084-5621 6279-6331 HPMJI81 876 930873 AC024077 7068  1-407 HPMJI81 876 930873 AC005392 7069  1-557 HPMJI81 876 930873 AC005392 7070  1-524 HPMJI81 876 930873 AC005337 7071  1-521 HPMJI81 876 930873 AC004603 7072  1-407 HPMJI81 876 930873 AC004603 7073   1-1485 HPMJN59 877 946876 AC011846 7074  1-137 1376-1529 3692-3832 4686-4797 HPMJV08 880 958001 AC027776 7075  1-524 HPMJV08 880 958001 AC011087 7076  1-531 HPMJV08 880 958001 AC011087 7077  1-313 HPMJV08 880 958001 AC011087 7078  1-858 HPMKB19 882 969478 AC068403 7079  1-803 HPMKB19 882 969478 AC006453 7080  1-806 HPMKB19 882 969478 AC068403 7081   1-1328 HPMKB19 882 969478 AC006453 7082   1-1333 HPMKI53 883 957997 AC023331 7083  1-126 310-498 668-972 1409-1497 3701-4076 HPMKI53 883 957997 AL358236 7084  1-305 HPMKI53 883 957997 AL359374 7085  1-126 310-486 668-972 1409-1497 3704-4079 HPMKI53 883 957997 AC023331 7086  1-332 HPMKI53 883 957997 AL358236 7087  1-189 HPMKI53 883 957997 AL359374 7088  1-355 HPMKI53 883 957997 AL359374 7089  1-87 HPMKM81 884 894416 AC004774 7090  1-741 2632-2831 3934-4654 HPMRM81 884 894416 AC004774 7091  1-239 HPMLE04 886 867533 AC011374 7092  1-81 1539-1599 2994-3084 4479-4645 6408-7106 7597-8047 8608-8758 9415-9596  9701-10049 10092-10403 10435-10769 11974-12131 12474-14769 HPMLE04 886 867533 AC011374 7093  1-465 HPMLE04 886 867533 AC011374 7094  1-174 HPMLK02 887 918123 Z93244 7095  1-730 HPMLK02 887 918123 Z93244 7096  1-137 HPMLK02 887 918123 Z93244 7097  1-329 HPMLW10 890 963037 Z71183 7098  1-650  910-1011 1092-1374 1570-3575 4833-5148 5950-6339 6825-8772 HPMLW10 890 963037 Z71183 7099  1-370 HPMLW10 890 963037 Z71183 7100  1-547 HPMSF86 891 509490 AC073118 7101  1-332 HPMSF86 891 509490 AC073118 7102  1-416 HPRAU45 894 536630 AL358777 7103  1-228 HPRAU45 894 536630 AL358777 7104  1-130 421-904 1651-2220 HPRAZ10 895 968692 AP002391 7105  1-684 HPRAZ10 895 968692 AP001813 7106  1-684 HPRAZ10 895 968692 AP001354 7107  1-684 HPRAZ10 895 968692 AP001813 7108  1-801 HPRAZ10 895 968692 AP001354 7109  1-801 HPRAZ10 895 968692 AP002391 7110  1-812 HPRBA65 896 655537 AC00S1S6 7111  1-75 210-244 676-737 1197-1292 2540-2624 3457-4334 5676-5802 6374-6668 7168-7566 8477-9182  9877-10179 10809-11521 11664-11764 12167-15152 15313-17601 HPRBA65 896 655537 AC005156 7112  1-384 HPRBL91 898 655693 AC027598 7113  1-287 HPRBL91 898 655693 AC002366 7114   1-1471 2332-2618 2700-3922 HPRBL91 898 655693 AC027598 7115  1-213 HPRBL91 898 655693 AC002366 7116  1-649 HPRCB11 899 960316 AC027430 7117   1-1109 HPRCB11 899 960316 AC025060 7118   1-1109 HPRCB11 899 960316 AL356216 7119   1-1109 HPRCB11 899 960316 AC027430 7120  1-283 1252-1520 3140-3531 3872-4195 5194-5332 HPRCB11 899 960316 AC025060 7121  1-325 1292-1560 3180-3571 3912-4235 5234-5372 HPRCB11 899 960316 AL356216 7122  1-165  983-1294 2273-2541 4161-4552 4893-5211 6214-6352 HPRCB21 900 655725 AL359979 7123  1-462 HPRCB21 900 655725 AC007198 7124  1-38 1466-1583 3807-4268 5971-6192 8369-8478 8487-8559 8759-8854 10151-10561 10604-10767 HPRCB21 900 655725 AC007198 7125  1-375 HPRCN41 903 655554 AL118505 7126  1-340 HPRSB16 905 666295 AC025744 7127  1-600 HPRSB16 905 666295 AC009532 7128  1-600 HPRTL26 906 849081 AC023670 7129  1-494 HPRTL26 906 849081 AC006209 7130  1-494 HPRTL26 906 849081 AC023670 7131  1-421 HPRTL26 906 849081 AC023670 7132  1-143 HPRTL26 906 849081 AC006209 7133  1-421 HPRTL26 906 849081 AC006209 7134  1-316 HPVAB11 908 967944 AL132765 7135  1-317  513-1129 1393-1812 2172-2279 3387-3604 3756-4196 4605-5222 6088-7636 8449-9183 HPVAH36 911 525537 AC069506 7136  1-484 HPVAH36 911 525537 AC069506 7137  1-109 HPWAF85 912 655691 AC067852 7138  1-269 1060-1197 2413-2501 2742-2824 3029-3345 3516-3646 4050-5214 HPWAF85 912 655691 AC067852 7139  1-462 HPWAF85 912 655691 AC067852 7140   1-1449 HPWAH48 913 655527 AC021302 7141  1-771 HPWAH48 913 655527 AP002410 7142  1-771 HPWAH48 913 655527 AC027229 7143  1-771 HPWAH48 913 655527 AC021302 7144  1-577 HPWAH48 913 655527 AC027229 7145  1-577 HPWAS77 914 908450 AL360009 7146  1-899 HPWAS77 914 908450 AL360009 7147  1-439 HPWBA33 915 655733 AC011893 7148  1-218 363-880 HPWBA33 915 655733 AC008693 7149  1-475 551-760 HPWBA33 915 655733 AC008793 7150  1-218 HPWBO84 916 867289 AC019236 7151  1-123  882-1040 2914-3294 3442-3565 3817-3937 HPWCJ27 918 655614 AC013537 7152  1-478 HPWDA86 922 961529 AC025052 7153  1-252 HPWDA86 922 961529 AC007908 7154  1-423 HPWDA86 922 961529 AC060805 7155  1-509 HPWDA86 922 961529 AC073210 7156  1-508 HPWDA86 922 961529 AC024972 7157  1-602 HPWDA86 922 961529 AC016424 7158  1-424 HPWDA86 922 961529 AC026106 7159  1-204 HPWDA86 922 961529 AF254982 7160  1-201 HPWDA86 922 961529 AC006352 7161   1-1265 1916-2604 2661-3249 3978-4705 4940-6193 6404-6826  8773-10518 10889-11233 11898-12329 12356-12820 15993-16294 24465-25008 25659-25803 26371-27137 29043-29527 32143-32572 33008-33621 35141-35475 36748-37095 38180-38873 38879-39078 39939-40330 40474-41066 41075-41810 41904-42646 43264-47127 47426-49777 HPWDA86 922 961529 AC002038 7162  1-203 HPWDA86 922 961529 AC002041 7163  1-423 HPWDA86 922 961529 AC007882 7164  1-423 HPWDA86 922 961529 AC025052 7165  1-352 HPWDA86 922 961529 AC007908 7166   1-1951 HPWDA86 922 961529 AC060805 7167  1-369 HPWDA86 922 961529 AC073210 7168  1-333 HPWDA86 922 961529 AC024972 7169   1-1002 HPWDA86 922 961529 AC060805 7170   1-1004 1014-1114 HPWDA86 922 961529 AC073210 7171  1-960 HPWDA86 922 961529 AC024972 7172   1-2119 HPWDA86 922 961529 AC016424 7173   1-1103 HPWDA86 922 961529 AC016424 7174   1-1003 HPWDA86 922 961529 AC026106 7175  1-426 HPWDA86 922 961529 AC006352 7176  1-661  844-1386 HPWDA86 922 961529 AF254982 7177  1-824  831-1109 HPWDA86 922 961529 AC006352 7178  1-247 320-743 1068-1252 1590-2004 2516-2705 3290-3582 3755-4299 4884-5079 HPWDA86 922 961529 AC002041 7179   1-1951 HPWDA86 922 961529 AC002038 7180   1-1110 HPWDA86 922 961529 AC002041 7181  1-959 HPWDA86 922 961529 AC007882 7182   1-1951 HPWDA86 922 961529 AC007882 7183  1-959 HPWDD72 923 537333 AC005189 7184  1-799 HPWDD72 923 537333 AC005189 7185  1-411 HPWDD72 923 537333 AC005189 7186  1-619 KPWSB35 924 655713 AC026075 7187  1-358 393-922 HPWSB35 924 655713 AC026075 7188  1-100 HPZAB38 925 655591 AC008954 7189  1-263 HPZAB38 925 655591 AC026707 7190  1-263 HPZAB38 925 655591 AC008971 7191  1-263 HPZAB38 925 655591 AC026707 7192  1-186 HPZAB38 925 655591 AC008971 7193  1-180 HSWAD39 927 705322 AC010076 7194   1-1083 HSWAD39 927 705322 AC010076 7195  1-625 HSWBD86 928 785439 AC009700 7196  1-859 HSWBD86 928 785439 AC051619 7197  1-143 2883-3799 3860-4084 4588-4731 4805-5240 5789-6236 6303-6916 7595-7957 10174-11092 HSWBD86 928 785439 AC009700 7198   1-1558 2105-2231 2334-2387 HSWBD86 928 785439 AC051619 7199   1-1558 2093-2219 2322-2375 HSWBD86 928 785439 AC051619 7200  1-155 HSWBJ40 929 711066 AC046165 7201  1-782 HSW3J40 929 711066 AC034220 7202  1-782 HSWBJ40 929 711066 AC034220 7203  1-545  914-1407 HSWBJ40 929 711066 AC046165 7204  1-87 410-529 561-954 HSWBJ40 929 711066 AC034220 7205  1-168 3854-3951 6063-6447 7841-7908 8322-8502 8704-8877 9198-9318 9350-9743 HTEAD95 934 961232 AC006445 7206   1-1321 HTEAF26 936 537271 AC022988 7207  1-319 HTEAG50 937 787500 AC026462 7208  1-310 HTEAG50 937 787500 AC026462 7209  1-250 HTEAR84 941 783328 AL133353 7210  1-222 225-361 2796-2928 4044-4119 5719-5962 7512-7571 10952-11165 11840-11870 15055-15191 17157-17497 18170-18193 19594-20180 20819-21289 21499-22434 22520-23934 HTEAR84 941 783328 AL133353 7211  1-200 456-609 5860-5998 6526-6629 8425-8724 9151-9625 12117-12252 15026-15571 15654-16121 16221-16852 19264-19592 21596-21794 22707-22795 23248-23407 23487-23890 25183-26429 26561-27890 28380-28908 28953-29430 29490-32385 32577-35455 36789-37427 37736-38206 38250-38308 38867-39048 39075-39236 39491-39811 39971-40302 40401-40871 41105-41186 41719-41801 43440-43567 43732-44141 44689-44855 46395-46619 47357-47643 47700-47887 48174-48294 48469-48728 50284-50469 52382-52845 HTEAR84 941 783328 AL133353 7212  1-445 HTEAV43 942 927010 AL365184 7213  1-577 HTEAZ54 944 793441 AC024644 7214  1-521 HTEAZ54 944 793441 AC008555 7215  1-797 1423-1942 2185-2716 2806-4251 HTEAZ54 944 793441 AC024644 7216  1-97 HTEBC74 945 887782 AC022247 7217  1-148 2458-2630 HTEBD35 946 967959 AC072024 7218  1-317 HTEBD35 946 967959 AL353796 7219  1-317 HTEBD35 946 967959 AL360172 7220  1-317 HTEBJ78 948 779265 AP001177 7221   1-1021 3487-4086 4668-5157 5193-5665 5913-7625 HTEBJ78 948 779265 AC016186 7222   1-1021 HTEBJ78 948 779265 AC016127 7223   1-1021 2300-2622 3488-4067 HTEBJ78 948 779265 AP001164 7224   1-1021 2463-2587 3494-4093 4675-5164 5200-5672 5920-7633 HTEBJ78 948 779265 AC023989 7225   1-1021 2300-2622 3488-4067 HTEBJ78 948 779265 AP001164 7226  1-340 HTEBJ78 948 779265 AC023989 7227  1-340 HTEBJ78 948 779265 AC016186 7228  1-340 HTEBJ78 948 779265 AC016127 7229  1-340 HTEBJ78 948 779265 AC023989 7230  1-490 HTEBX62 953 508150 AC068620 7231  1-584 HTEBX62 953 508150 AC068620 7232   1-2496 2639-3538 HTEBY15 955 526281 AL117259 7233  1-260 HTEBY41 957 711523 AL357093 7234  1-229 HTEBY41 957 711523 AL157736 7235  1-229 HTEBY41 957 711523 AL357093 7236  1-142 HTEBY41 957 711523 AL357093 7237  1-455 HTEBY41 957 711523 AL157736 7238  1-142 HTEBY41 957 711523 AL157736 7239  1-455 HTEBY61 958 967340 AC020663 7240  1-150 1916-2097 3254-3396 4731-5065 5605-5801 5830-6113 6544-6716 7594-8121 8494-8612 8752-9291 9401-9505 10308-10582 11826-11970 12379-12478 12796-13085 13942-14925 HTEBY61 958 967340 AC020663 7241  1-265 HTEBZ21 959 958381 AL390764 7242  1-101  236-1007 1038-1344 1353-1493 1641-1750 1837-2006 2542-2700 3557-3720 4326-9299  9617-10008 10623-11068 11238-11714 11800-11992 12001-12566 13314-15677 15882-16457 16614-17442 17850-18427 19713-19802 HTEBZ21 959 958381 AL135843 7243  1-32 1420-1543 2122-2266 2730-3022 3914-4068 4197-4968 4999-5305 5314-5454 5602-5711 5798-5967 6503-6661 7518-7681  8287-13260 13578-13969 14584-15029 15199-15675 15761-15953 15962-16527 17275-19638 19843-20418 20575-21403 HTEBZ21 959 958381 AL136105 7244  1-576 HTEBZ21 959 958381 AL359921 7245  1-703 1021-1412 2027-2470 2640-3116 3202-3394 3403-3968 4716-7079 7284-7859 8016-8844 9252-9829 11115-11204 HTEBZ21 959 958381 AL136105 7246  1-32 1420-1543 2122-2266 2730-3022 3914-4068 4197-4968 4999-5305 5314-5454 5602-5711 5798-5967 6503-6661 7518-7681  8287-13260 13578-13969 14584-15029 15199-15675 15761-15953 15962-16527 17275-19638 19843-20418 20575-21403 21811-22388 23674-23763 HTEBZ21 959 958381 AL136105 7247  1-311 HTEBZ21 959 958381 AL390764 7248  1-287 HTEBZ21 959 958381 AL135843 7249  1-302 HTEBZ21 959 958381 AL136105 7250   1-1122 HTEBZ21 959 958381 AL359921 7251  1-347  661-1203 1533-2057 2287-2445 3335-3716 5741-6053 HTEBZ21 959 958381 AL136105 7252  1-347  661-1203 1533-2057 2287-2445 3335-3716 5729-6044 HTEBZ21 959 958381 AL136105 7253  1-302 HTECA16 961 764416 AC011726 7254  1-470 HTECA16 961 764416 AC022911 7255  1-470 HTECA16 961 764416 AC011726 7256  1-500 HTECA16 961 764416 AC022911 7257  1-500 HIECA51 964 708860 AL035450 7258  1-93 1880-3178 HTECA51 964 708860 AL035450 7259  1-105 HTECC13 967 971673 AC018638 7260  1-252 3348-3556 3720-3822 3877-4004 4927-5181 5226-5736 HTECC13 967 971673 AC018638 7261  1-130 HTECC37 969 508143 AC073270 7262  1-416 HTECC37 969 508143 AC022202 7263  1-416 HTECC80 972 796820 AC016767 7264  1-35 784-988 1186-1254 1854-2737 HTECC80 972 796820 AL353608 7265  1-140 1348-1579 1810-2502 2585-2694 2831-3054 3202-3273 3513-3903 4019-4053 4802-5008 5205-5273 5873-6756 HTECC80 972 796820 AL078621 7266  1-35 784-988 1187-1255 1855-2739 HTECC80 972 796820 AC016767 7267  1-103 HTECC96 974 959874 AC025977 7268   1-1286 HTECC96 974 959874 AC040170 7269   1-1286 HTECC96 974 959874 AC013513 7270   1-1286 HTECD17 975 508108 AC013812 7271  1-700 HTECD17 975 508108 AL136360 7272  1-707 HTECD17 975 508108 AL132868 7273  1-712 HTECD17 975 508108 AL136360 7274  1-263 HTECD17 975 508108 AL132868 7275   1-1166 HTECD36 977 518124 AL132780 7276  1-562  736-1855 1931-2051 2232-2897 3495-3673 3759-3882 3968-4030 4121-4203 4369-4532 5620-6405 7007-7151 7615-7702 7882-8106 8655-8942 HTECD36 977 518124 AL132780 7277   1-1058 1452-2073 HTECE44 981 764830 AC026957 7278  1-198 2840-3137 3146-3524 3811-4890 6360-6479 7798-8125 13068-13250 14052-14252 HTECE44 981 764830 AC026957 7279  1-626 1734-2270 HTECE44 981 764830 AC026957 7280  1-514 HTECE91 984 522984 AC021586 7281   1-1460 4600-4966 5827-6179 6596-7246 8893-9973  9991-10696 10851-11246 11352-11783 11934-12787 12926-13555 HTECE91 984 522984 AC021586 7282  1-310 HTECE91 984 522984 AC021586 7283  1-227 HTEDF13 985 522964 AL133499 7284  1-370 HTEDF13 985 522964 AP001579 7285  1-370 HTEDF13 985 522964 AL133499 7286  1-373 HTEDF13 985 522964 AP001579 7287  1-373 HTEDF76 988 522973 AC073612 7288  1-445 HTEDF76 988 522973 AC011601 7289  1-445 HTEDF76 988 522973 AC073612 7290   1-1099 HTEDF76 988 522973 AC011601 7291   1-1099 HTEDG16 989 925527 AC008547 7292  1-196 5138-6241 HTEDG16 989 925527 AC008547 7293  1-615 HTEDI82 996 536477 AL359455 7294  1-396 561-837 2703-2900 3015-3099 HTEDI82 996 536477 AL359455 7295  1-99 404-514 597-985 HTEDJ04 997 519940 AL359767 7296  1-363 411-960 HTEDJ04 997 519940 AL139377 7297  1-363 411-960 HTEDJ04 997 519940 AL359767 7298   1-1831 HTEDJ04 997 519940 AL359767 7299  1-430 HTEDJ04 997 519940 AL139377 7300  1-27  318-1304 2398-3171 3518-4027 4716-4919 6801-6956 9618-9892  9938-10400 10485-11629 14162-18670 18980-19880 20136-20686 21997-22089 23839-23999 24083-24175 25513-26022 27060-27487 27557-28168 28906-29445 31090-31363 31403-31488 31669-33499 HTEDJ04 997 519940 AL139377 7301  1-430 HTEDJ30 998 771404 AC009871 7302   1-1510 HTEDJ30 998 771404 AC009812 7303   1-1510 HTEDJ30 998 771404 AC009871 7304  1-448 HTEDJ30 998 771404 AC009812 7305  1-555 HTEDM08 999 960303 AF215848 7306  1-170 294-404 HTEDM08 999 960303 AC009314 7307  1-171 295-405 HTEDM08 999 960303 AF215848 7308  1-317 HTEDM08 999 960303 AC009314 7309  1-319 HTEDO31 1000 870711 AC066613 7310  1-279 HTEDO31 1000 870711 AC021238 7311  1-279 HTEDO51 1001 530592 AL390816 7312  1-67 5510-5778 HTEDO59 1002 964379 AL0S0310 7313  1-421 HTEDO59 1002 964379 AL161442 7314  1-421 HTEDO59 1002 964379 AL050310 7315  1-860 HTEDO59 1002 964379 AL050310 7316  1-342 HTEDO59 1002 964379 AL161442 7317  1-518 HTEDO59 1002 964379 AL161442 7318   1-3019 HTEDP15 1003 870675 AC008119 7319  1-129 1226-2057 3894-4078 4353-5054 5261-6347 6614-7200 9168-9576 10127-10285 11014-11729 11817-12350 12430-12511 12645-12705 13644-13859 15181-15386 16010-16997 17664-18577 18904-19074 20351-20663 20725-20760 22661-23119 23379-23760 24351-24525 24708-25559 25582-29154 29209-29484 29561-30822 31196-31337 31407-31850 31943-32302 33856-33927 HTEDP15 1003 870675 AC008119 7320  1-254 HTEDP31 1004 870548 AC004674 7321  1-660 HTEDP31 1004 870548 AC004674 7322  1-139 HTEDQ30 1007 530589 AC011181 7323  1-683 HTEDQ30 1007 530589 AC011181 7324  1-443 HTEDQ30 1007 530589 AC011181 7325  1-275 HTEDQ83 1009 530586 AC018935 7326  1-491 HTEDR71 1010 761585 AJ239328 7327  1-367  884-2043 2287-2859 4457-4512 4780-6360 9237-9407 10873-11661 HTEDR71 1010 761585 AP000219 7328  1-367  884-2043 2287-2859 4457-4512 4780-6360 9237-9407 10903-11691 HTEDR71 1010 761585 AP000341 7329  1-367  884-2043 2287-2859 4457-4512 4780-6360 9237-9407 10903-11691 HTEDR71 1010 761585 AJ239328 7330  1-241 HTEDR71 1010 761585 AP000219 7331  1-241 HTEDR71 1010 761585 AP000341 7332  1-241 HTEDU48 1013 932315 AC026083 7333   1-1222 HTEDU48 1013 932315 AC026083 7334  1-416 HTEDU48 1013 932315 AC026083 7335  1-442 HTEEA03 1020 925399 AC010934 7336   1-1173 1296-2904 2911-4546 HTEEA03 1020 925399 AC044879 7337   1-1173 1296-2905 2912-4547 HTEEA03 1020 925399 AC010934 7338   1-1008 HTEEA03 1020 925399 AC044879 7339  1-692 HTEEA03 1020 925399 AC010934 7340  1-692 HTEEA03 1020 925399 AC044879 7341   1-1008 HTEEE65 1024 530157 AC011830 7342  1-164 2053-2094 2375-2846 HTEEE65 1024 530157 AC018502 7343  1-164 2053-2094 2375-2846 HTEEE65 1024 530157 AC018499 7344  1-164 2053-2094 2375-2846 HTEEE65 1024 530157 AC018502 7345   1-2058 HTEEU23 1027 524059 AL355801 7346  1-359 3545-3632 6187-6329 7609-7687 HTEEU23 1027 524059 AL355801 7347  1-939 1454-1932 2912-3240 3284-3953 HTEEW73 1032 917206 AL355377 7348  1-83 578-621 1159-1219 2182-2285 2508-2616 6024-6598 HTEFJ53 1034 935982 AC019031 7349  1-710 HTEFJ53 1034 935982 AC019031 7350  1-405 HTEFO32 1037 529272 AL133264 7351  1-190 1330-1629 2351-5250 5255-5600 5635-9271  9938-10152 10897-11597 11951-12840 13095-13296 13340-13626 13704-14430 14536-14639 15282-15909 16437-16561 18269-18449 20662-21446 21484-22073 HTEFO76 1038 770270 AC055733 7352  1-160  888-1009 1771-2022 HTEFO76 1038 770270 AC025148 7353  1-322  946-1105 1827-1948 2710-2961 HTEFO76 1038 770270 AC025148 7354  1-924 1228-1751 1793-2057 2224-2959 3239-3297 4754-4965 5736-6035 8675-9217 10252-11580 11720-11844 12753-13021 HTEFS60 1042 836010 Z84469 7355  1-640 HTEFW55 1044 787550 AL138975 7356  1-703 HTEFW55 1044 787550 AC011190 7357  1-703 HTEFW55 1044 787550 AL162171 7358  1-118 600-642 4987-5103 8034-8072 8978-9174 9525-9958 10048-10357 10648-11468 11642-12760 12786-12888 13913-14249 14931-15063 15738-16168 16205-16345 17103-17538 20097-20865 21389-21912 24378-24502 24644-25083 27767-28008 28873-29360 31358-32060 36985-37295 38992-39029 39774-40017 44189-44310 44400-44530 46199-46350 46476-46750 47107-47593 47781-48000 48185-48492 48689-50784 HTEFW55 1044 787550 AL162171 7359   1-1502 HTEFW55 1044 787550 AL162171 7360  1-294 309-744 HTEFX53 1047 842047 AC019054 7361   1-1177 HTEFX53 1047 842047 AC019054 7362  1-272 HTEGA13 1048 656077 AC016366 7363  1-124  250-1075 1645-1784 3488-3903 4325-4378 5000-5066 5729-5862 HTEGA13 1048 656077 AC005237 7364  1-129 864-968 2110-2704 2874-3374 3897-4026 4152-4977 5547-5686 7392-7807 8227-8285 8903-8970 9633-9766 10230-10642 10754-10917 13200-13823 15685-15784 16202-16302 16342-16496 16754-16865 17467-17820 20203-20289 25130-25260 26385-26486 28046-28566 28884-28989 30114-30820 33068-33452 HTEGA13 1048 656077 AC005237 7365  1-592 HTEGF95 1055 796660 AC023097 7366   1-1019 1110-1237 1879-2520 2630-2722 2971-3623 3632-3799 4789-5451 5681-5917 6015-6176 7511-7632 7814-8250 9336-9535  9998-11067 12025-12474 14608-14706 15489-15605 16481-16607 HTEGF95 1055 796660 AC023097 7367  1-600 HTEGF95 1055 796660 AC023097 7368  1-388 HTEGG07 1056 954115 AC011842 7369  1-486 HTEGG07 1056 954115 AC011842 7370  1-606 HTEGG61 1057 528007 AC009220 7371  1-627 HTEGG61 1057 528007 AC009220 7372  1-303 HTEGG61 1057 528007 AC009220 7373  1-123 HTEGK51 1058 520046 AC008555 7374  1-797 1423-1942 2185-2716 2806-4251 HTEGU13 1071 520041 AC036208 7375  1-388 3367-3638 4217-4390 4594-4868 6530-6680 7892-7971 9392-9567 10136-10429 HTEGU13 1071 520041 AC036208 7376  1-156 HTEGU62 1073 573885 AC036238 7377  1-402 HTEGU62 1073 573885 AC036238 7378  1-256 HTEGU62 1073 573885 AC036238 7379  1-150 HTEGU93 1074 764831 AC026957 7380  1-198 2840-3137 3146-3524 3811-4890 6360-6479 7798-8125 13068-13250 14052-14252 HTEGU93 1074 764831 AC026957 7381  1-626 1734-2270 HTEGU93 1074 764831 AC026957 7382  1-514 HTEGV60 1076 822954 AC013414 7383  1-138 550-714 2702-3122 3973-4262 4649-4745 5363-7228 HTEGV60 1076 822954 AC016171 7384  1-127 1017-1306 1693-1789 2407-5049 HTEGV60 1076 822954 AC016171 7385   1-4710 HTEGV84 1077 870240 AC027120 7386   1-1730 HTEGV84 1077 870240 AC023877 7387   1-1730 HTEGV84 1077 870240 AC027120 7388  1-85 HTEGV84 1077 870240 AC023877 7389  1-85 HTEGW41 1078 573880 AL135939 7390  1-541 HTEGW94 1079 794350 AC022672 7391   1-1334 1951-2103 HTEGW94 1079 794350 AC022672 7392   1-5446 HTEGX74 1080 783829 AC027396 7393  1-95 227-318 546-654 669-792 1355-1766 HTEGX74 1080 783829 AC027396 7394   1-1730 HTEGY01 1081 917214 AC009061 7395  1-123 4295-4489 5148-5404 5536-5632 HTEGY01 1081 917214 AC009061 7396  1-101 HTEHB07 1083 870707 AC020575 7397  1-625 1178-1625 HTEHB07 1083 870707 AC027000 7398  1-625 1177-1624 HTEHC60 1086 965998 AC007343 7399  1-695 HTEHC60 1086 965998 AC018553 7400  1-695 HTEHC60 1086 965998 AC007343 7401  1-494 HTEHC60 1086 965998 AC018553 7402  1-494 HTEHE60 1088 795264 AC007114 7403  1-738 HTEHE60 1088 795264 AC007114 7404  1-359 HTEHE78 1090 932312 AC022621 7405  1-419 HTEHE78 1090 932312 AC022621 7406  1-634 HTEHE78 1090 932312 AC022621 7407  1-398 HTEHF66 1093 836999 AL109657 7408  1-67 611-694 1472-1552 7387-7447 7998-8086 10739-10859 HTEHI93 1099 870629 AL121926 7409  1-402 HTEHX32 1122 772643 AL049742 7410  1-694 HTETA80 1126 721831 AC021473 7411  1-258 HTEIA80 1126 721831 AC016310 7412  1-257 HTEIA80 1126 721831 AC021473 7413  1-114 HTEIA80 1126 721831 AC016310 7414  1-114 HTEIB14 1127 963099 AC016877 7415  1-369  817-2106 2511-2860 4380-5157 6201-6321 7064-7649 11036-11360 HTEIB14 1127 963099 AC016877 7416  1-139 HTEIF40 1128 958355 AL157687 7417  1-40 249-903 1489-1913 2058-2116 2558-2733 2737-2876 3462-3623 5522-5820 5917-6004 HTEIF40 1128 958355 AL161668 7418  1-40 249-903 1489-1913 2058-2116 2558-2892 3479-3633 5532-5830 5927-6014 HTEIF40 1128 958355 AL157687 7419  1-307 HTETE40 1128 958355 AL161668 7420  1-307 HTEIF68 1129 573828 AP001887 7421  1-311 HTEIF68 1129 573828 AP002008 7422  1-311 HTETE68 1129 573828 AP001887 7423  1-107 HTETF68 1129 573828 AP002008 7424  1-357 HTEIF68 1129 573828 AP001887 7425  1-357 HTELF68 1129 573828 AP002008 7426  1-107 HTEIH70 1131 573826 AC020908 7427  1-85  759-1469 2611-2787 3133-3229 3908-3972 4076-4239 5908-6009 6780-6924 8969-9104 9180-9480  9730-10047 10173-10906 12607-13024 HTETH70 1131 573826 AC020908 7428  1-183 HTEIK11 1136 967431 AC018924 7429  1-215 1942-2409 3011-3645 4383-5366 HTEIK11 1136 967431 AC018924 7430  1-927 HTEIK90 1138 789121 AL161442 7431  1-380 HTEIK90 1138 789121 AL161442 7432  1-185 1241-1480 3780-4356 5514-5666 6203-6495 6752-7126 7461-7946 10053-10148 10892-10967 12645-13553 HTEIK90 1138 789121 AL161442 7433  1-323 HTEIL48 1140 523681 AC026861 7434  1-38 601-692 1658-1810 2194-2275 HTEIO02 1145 920622 AC010632 7435  1-38 1512-1878 2899-2944 3751-4080 HTEIO02 1145 920622 AC010632 7436  1-523 HTEIO02 1145 920622 AC010632 7437  1-394 HTEIO28 1147 573803 AC067839 7438  1-489 HTEIO28 1147 573803 AC007898 7439  1-489 HTEIO28 1147 573803 AL359508 7440  1-346 HTEIP88 1148 941155 AC068659 7441  1-51 583-821 4529-4916 5879-6079 6298-6442 7345-7447 7836-8136 8423-8833 12525-12677 13528-13727 14268-14602 14605-14655 15410-15666 17282-18408 HTEIP88 1148 941155 AC012183 7442  1-51 583-821 4528-4915 5878-6078 6297-6441 7344-7446 7835-8135 8422-8832 12525-12677 13529-13728 14269-14603 14606-14656 15410-15666 17282-18408 HTEIP88 1148 941155 AC068659 7443  1-482 HTEIP88 1148 941155 AC012183 7444  1-482 HTEIP88 1148 941155 AC068659 7445   1-1254 HTEIP88 1148 941155 AC012183 7446   1-1254 HTEIP92 1149 523892 AC013252 7447  1-368 HTEIP92 1149 523892 AC013252 7448  1-952 HTEIP92 1149 523892 AC013252 7449  1-413 HTEIQ74 1150 765794 AC055815 7450  1-681 HTEIQ74 1150 765794 AC026801 7451  1-681 HTEIQ74 1150 765794 AC008690 7452  1-681 HTEIQ74 1150 765794 AC055815 7453  1-435 HTEIQ74 1150 765794 AC026801 7454  1-435 HTEIQ74 1150 765794 AC008690 7455  1-435 HTEIR33 1151 928058 AL139130 7456  1-164 346-423 545-673 1188-1349 3339-3655 4129-4219 6133-6265 8323-8553 HTEIR33 1151 928058 AL139130 7457  1-196 418-529 695-927 1596-1660 1751-1803 2056-2085 2710-2770 3176-4018 5037-5258 HTETU75 1153 779163 AL390863 7458  1-51  469-1032 HTETU75 1153 779163 AL136370 7459  1-51  469-1032 HTEIV86 1156 784657 AC021467 7460  1-44 1339-1503 2150-2290 3993-4708 HTEJV86 1156 784657 AC009761 7461  1-112 759-899 2602-3318 HTEIX28 1159 836011 AL356489 7462  1-445 884-998 1226-3051 HTEIX28 1159 836011 AL356489 7463  1-446 885-999 1227-1523 1744-2100 2129-2588 2592-3047 HTEIX28 1159 836011 AL139008 7464  1-446 885-999 1227-1523 1744-2100 2129-2588 2592-3047 HTEIX28 1159 836011 AL356489 7465  1-220 HTEIX28 1159 836011 AL356489 7466   1-1564 HTEIX28 1159 836011 AL356489 7467  1-671 1240-1821 2574-3013 HTEIX28 1159 836011 AL139008 7468   1-1564 HTEIX28 1159 836011 AL139008 7469  1-671 1240-1821 2574-3013 HTEIX85 1160 864251 AL161614 7470   1-2924 3023-4030 5001-5171 7210-7434 7618-7734 9610-9764 10165-10247 11951-12426 12489-12966 12976-14097 14682-14894 15043-15480 15790-16240 18111-18240 19064-19538 21727-21871 22803-22927 HTEIY52 1161 963536 AC067940 7471  1-358 HTETY52 1161 963536 AC067940 7472  1-304 HTEIY69 1162 577783 AC013615 7473   1-1089 HTEIY69 1162 577783 AC019281 7474   1-1089 HTEIY69 1162 577783 AC013615 7475  1-386 HTEIY69 1162 577783 AC019281 7476  1-386 HTEJB81 1167 870644 AC005230 7477   1-2439 8407-8470  9530-10042 10151-10292 10994-11489 13344-13495 13839-13947 14210-14368 14468-14896 15070-15109 16186-16476 24845-25151 28921-29859 29894-29983 30274-30383 30713-30861 35512-35834 36301-36697 38147-38284 39209-39428 40566-40976 42730-43452 44036-44488 45502-45786 46083-46155 46163-46724 HTEJB81 1167 870644 AC005230 7478  1-395 HTEJB81 1167 870644 AC005230 7479  1-400 HTEJC28 1168 573774 AL358214 7480  1-298 HTEJE15 1170 908360 AC016632 7481  1-220 361-469 1509-2194 HTEJE15 1170 908360 AC016639 7482  1-220 362-470 1510-2195 HTEJE15 1170 908360 AC008914 7483  1-220 361-469 1512-2197 HTEJG24 1173 526278 AL139237 7484  1-430 HTEJG24 1173 526278 AC025004 7485  1-430 HTEJG24 1173 526278 AC021540 7486  1-430 HTEJJ43 1174 774243 AC018519 7487  1-214 309-383 1911-2211 2693-2983 3679-4166 4899-4949 9474-9544 HTEJJ43 1174 774243 AC018519 7488  1-611 HTEJM56 1176 952255 AC025036 7489  1-148 HTEJM56 1176 952255 AC027300 7490  1-158 HTEJM56 1176 952255 AC016327 7491  1-165 HTEJM56 1176 952255 AC016327 7492  1-195 HTEJN49 1178 558383 AL354888 7493  1-250 HTEJN49 1178 558383 AC067884 7494  1-250 HTEJN49 1178 558383 AL033527 7495  1-250 HTEJN49 1178 558383 AL354888 7496  1-391 HTEJN49 1178 558383 AC067884 7497  1-391 HTEJN49 1178 558383 AL033527 7498  1-392 HTEJT37 1183 530596 AC011318 7499  1-170 4244-4812 HTEJT37 1183 530596 AC027296 7500  1-404 HTEJT37 1183 530596 AC012340 7501  1-404 HTEJX78 1187 806395 AL136373 7502  1-131  694-1754 HTEJX78 1187 806395 AL357392 7503  1-112  675-1735 HTEJX78 1187 806395 AC013593 7504  1-131  694-1754 HTEJX78 1187 806395 AL357392 7505   1-3661 5981-6371 6517-7301 8141-8268 9332-9897 11527-11603 11625-11713 13194-13546 14430-14533 16668-16939 HTEJX78 1187 806395 AL136373 7506  1-217 HTEJX78 1187 806395 AC013593 7507   1-3662 5982-6372 6518-7302 8142-8269 9333-9446 9450-9898 11528-11604 11626-11714 13195-13547 14428-14534 16669-16940 18704-20067 20193-20457 20794-22689 HTEKC07 1191 920925 AL359708 7508  1-546 HTEKC07 1191 920925 AL139318 7509  1-546 HTEKD04 1193 519938 AC026525 7510   1-1001 1500-1654 1958-2325 HTEKF35 1199 573749 AC016878 7511  1-152 2683-2792 HTEKF35 1199 573749 AC023911 7512  1-152 2683-2792 HTEKF35 1199 573749 AC011272 7513  1-152 2681-2790 HTEKE35 1199 573749 AC023911 7514  1-218 HTEKF35 1199 573749 AC011272 7515  1-218 HTEKF68 1200 772997 AL357117 7516  1-634 HTEKF68 1200 772997 AC023219 7517  1-634 HTEKI70 1202 503039 AC009648 7518  1-230 1002-1211 1349-1470 2451-2575 2924-3218 3509-3805 HTEKI70 1202 503039 AC009648 7519  1-103 188-274 326-447 2665-2749 3400-4013 HTEKO49 1205 723148 AC021527 7520  1-159 330-389  747-1508 1628-1889 2484-3286 HTEKO49 1205 723148 AC006211 7521  1-159 330-389  747-1508 1628-1889 2484-3286 HTEKO49 1205 723148 AC021527 7522  1-233 HTEKO49 1205 723148 AC006211 7523  1-233 HTEKQ26 1206 870627 AC069404 7524  1-343 HTEKQ85 1207 784444 AP000879 7525  1-39 770-842 2822-3250 3862-4296 HTEKQ85 1207 784444 AP000879 7526  1-355 HTEKS20 1210 846714 AL137023 7527   1-1052 HTEKS20 1210 846714 AL137023 7528  1-868 1143-1650 HTEKS76 1212 767658 AC073366 7529  1-121  756-1172 HTEKS76 1212 767658 AC012683 7530  1-121  756-1172 HTEKS76 1212 767658 AC069546 7531  1-121  756-1172 HTEKX06 1213 935945 AC020603 7532  1-434 HTEKX06 1213 935945 AC020603 7533  1-89 HTEKX08 1214 959876 AC064835 7534   1-2215 HTEKX28 1215 920927 AC027120 7535   1-1730 HTEKX28 1215 920927 AC069399 7536   1-1153 HTEKX28 1215 920927 AC023877 7537   1-1730 HTEKX28 1215 920927 AC027120 7538  1-85 HTEKX28 1215 920927 AC023877 7539  1-85 HTEXZ50 1217 524054 AC008552 7540  1-424 HTEXZ50 1217 524054 AC008385 7541  1-424 HTEKZ50 1217 524054 AC008385 7542  1-435 HTELD47 1219 934272 AC017113 7543  1-883  888-1012 1959-2108 2538-3546 5010-5154 6554-6734 HTELD47 1219 934272 AL109804 7544  1-885  890-1014 1960-2109 2553-3562 5027-5172 6576-6756 HTELD47 1219 934272 AC017113 7545   1-1019 HTELD47 1219 934272 AL109804 7546  1-493  810-1071 1154-2175 HTELG47 1223 757740 AC024231 7547  1-377 458-535 HTELG47 1223 757740 AC016891 7548  1-377 458-535 HTELG47 1223 757740 AC024231 7549  1-533 HTELG47 1223 757740 AC016891 7550  1-533 HTELG57 1224 870621 AL356494 7551   1-2375 2863-3250 3804-3987 HTELG57 1224 870621 AL353662 7552   1-2375 2863-3250 3804-3987 HTELG57 1224 870621 AL356494 7553  1-538 HTELG57 1224 870621 AL356494 7554  1-85  637-1181 HTELG57 1224 870621 AL353662 7555  1-538 HTELG57 1224 870621 AL353662 7556  1-85  637-1181 HTELH44 1226 766462 AC006480 7557  1-266 1371-2150 HTELH44 1226 766462 AC006480 7558  1-369 HTELI03 1227 923071 AC068698 7559  1-587 HTELI03 1227 923071 AC005157 7560  1-587 HTELI03 1227 923071 AC068698 7561  1-276 HTELI03 1227 923071 AC068698 7562  1-527 HTELI03 1227 923071 AC005157 7563  1-527 HTELI03 1227 923071 AC005157 7564  1-273 HTELJ89 1229 966134 AL023585 7565  1-117 211-466 HTELJ89 1229 966134 AC024690 7566  1-123 217-474 HTELJ89 1229 966134 AL358783 7567  1-123 217-474 HTELJ89 1229 966134 AL023585 7568  1-122 217-474 HTELJ89 1229 966134 AL022101 7569  1-123 217-474 HTELK14 1230 794339 Z99716 7570  1-56 2209-2313 3622-3727 3907-4268 5968-6088 6723-7099 HTELK14 1230 794339 Z99716 7571  1-291 HTELK14 1230 794339 Z99716 7572  1-100 161-616 2777-2861 3555-3660 5314-5769 HTELK50 1231 870552 AC025953 7573  1-75 1003-1162 HTELK50 1231 870552 AL355516 7574  1-77 1002-1161 HTELK50 1231 870552 AC015873 7575  1-77 1002-1161 HTELK68 1232 923055 AL110504 7576  1-658 HTELK68 1232 923055 AL110504 7577  1-346 HTELK68 1232 923055 AL110504 7578  1-420 HTELL48 1233 783824 AC027195 7579  1-649 HTELL48 1233 783824 AC027195 7580  1-105 HTELL48 1233 783824 AC027195 7581  1-729 HTELO20 1237 926910 AL031597 7582  1-346 524-615 HTELO73 1239 761806 AL078613 7583  1-96 242-666 HTELO93 1240 934344 AC012391 7584  1-400 HTELO93 1240 934344 AC023283 7585  1-270 HTELO93 1240 934344 AC012308 7586  1-400 HTELO93 1240 934344 AC023283 7587  1-314 1245-1274 HTELO93 1240 934344 AC012308 7588  1-317 HTELO93 1240 934344 AC012308 7589  1-235 HTELQ87 1243 761768 AC024958 7590  1-404 2868-3192 HTELQ87 1243 761768 AC018422 7591  1-404 2868-3192 HTELT72 1245 761598 AC011237 7592  1-633 697-899 1405-1529 1983-2165 2371-2490 4239-4353 6793-6880 6993-8390 8442-8767 9115-9434 HTELT72 1245 761598 AF214633 7593  1-633 697-899 1405-1529 1983-2165 2371-2490 4239-4353 6793-6880 6993-8387 8439-8764 9112-9431 HTELT72 1245 761598 AC011237 7594   1-2683 2788-2900 3022-3162 3429-3503 3651-3777 4664-5070 5348-5888 6053-6296 6742-6875 7101-7249 7462-8011 8400-9118  9860-10566 10670-11294 HTELT72 1245 761598 AF214633 7595   1-2685 2790-2902 3024-3164 3431-3505 3653-3779 4666-5072 5351-5891 6056-6299 6745-6878 7104-7252 7465-8014 8403-9121  9863-10569 10673-11487 12212-12665 12994-13576 14033-14265 14998-15123 HTELT72 1245 761598 AC011237 7596  1-367 HTELT72 1245 761598 AF214633 7597  1-367 HTELU01 1247 915339 AL033517 7598  1-375 HTELV10 1249 963576 AC010339 7599  1-256 HTELV10 1249 963576 AC008674 7600  1-256 HTELV10 1249 963576 AC008674 7601  1-95 HTELW29 1253 952241 AC009131 7602  1-780 HTELW29 1253 952241 AC009131 7603  1-246 HTELW29 1253 952241 AC009131 7604  1-270 HTELX52 1255 963506 AL390858 7605  1-70  733-1332 HTELX52 1255 963506 AC026025 7606  1-70  733-1332 HTELX52 1255 963506 AL390858 7607  1-457 HTELX52 1255 963506 AC026025 7608  1-457 HTELX72 1256 761599 AC009682 7609  1-263 HTELX72 1256 761599 AL358940 7610  1-263 HTELY64 1257 764834 AL356056 7611  1-445 HTELY64 1257 764834 AL136982 7612  1-445 HTELY64 1257 764834 AL356056 7613  1-328 HTELY64 1257 764834 AL356056 7614  1-371 HTELY64 1257 764834 AL136982 7615  1-78 179-861 HTELY64 1257 764834 AL136982 7616  1-371 HTEMA54 1260 911666 AL359692 7617   1-1487 HTEMB26 1261 827055 AC004900 7618  1-112 HTEMB26 1261 827055 AC004900 7619   1-2372 2882-2974 3048-3578 4547-4806 5624-6285 7400-7547 10800-11164 11907-12010 16372-16542 17325-17552 19368-19662 22876-23302 28256-28683 31524-31990 35872-36237 36287-36728 37997-38535 38707-38829 39160-39466 40178-40339 40353-40480 40782-41520 42009-42538 HTEMB26 1261 827055 AC004900 7620   1-1968 HTEMB34 1263 870589 AL354940 7621  1-649 HTEMB34 1263 870589 AL157708 7622  1-649 HTEMB34 1263 870589 AL359554 7623  1-649 HTEMB83 1265 775593 AL050341 7624  1-294  621-1371 3345-3753 HTEMC75 1267 848193 AC074117 7625  1-93 317-475  850-1162 1511-2098 2194-4316 4373-4717 4836-5053 5192-5313 5403-5497 5798-6033 6121-6210 6370-6841 7244-7310 7582-7935 8489-8606 9212-9266 HTEMC75 1267 848193 AC074117 7626  1-70 485-599 880-966 1279-1414 2072-2489 3066-3209 3281-4159 4400-4694 4931-6271 HTEMD10 1268 963546 AC005858 7627  1-655 HTEMJ34 1271 786377 AC021491 7628  1-124 290-781 1447-1562 1650-1767 2309-2417 3273-3466 3935-4120 5213-5358 6216-6605 7621-7744 8491-8761 9044-9175 9353-9523  9966-10843 11395-11839 HTEMJ34 1271 786377 AC021491 7629  1-228 3662-4225 HTEMJ54 1272 963531 AC026334 7630   1-1272 1874-2420 4782-5167 5373-5502 5508-5671 5752-6010 6478-6836 7094-7292 7526-8820 9237-9731 HTEMJ54 1272 963531 AC060226 7631   1-1272 HTEMJ54 1272 963531 AC060226 7632  1-547 HTEMJ54 1272 963531 AC026334 7633  1-424 HTEMJ54 1272 963531 AC060226 7634  1-424 HTEMN08 1275 958374 AP001016 7635  1-248 HTEMN08 1275 958374 AC011077 7636  1-248 HTEMN08 1275 958374 AP002381 7637  1-248 HTEMN08 1275 958374 AC011077 7638  1-339 HTEMN08 1275 958374 AP001016 7639  1-339 HTEMN08 1275 958374 AP002381 7640  1-339 HTEMN95 1276 789113 AC005540 7641  1-157 1565-1735 HTEMP48 1279 767863 AL121747 7642  1-181 315-683 1416-1776 1804-2673 2940-3611 3880-4030 4596-4924 5925-6032 6514-6965 7032-7135 7196-7771 8229-8385 9347-9435 11732-13123 HTEMP48 1279 767863 AL049761 7643  1-573 2229-2431 2486-2797 3011-3299 3434-3924 4487-4614 5864-6151 6385-6768 6786-7099 7437-7594 7761-8029 8318-9645  9767-10324 10882-10944 11032-11505 12853-13033 13167-13535 14268-14627 14656-15525 15792-16463 16731-16911 17448-17776 18777-18886 19366-19817 19884-19987 20048-20606 21085-21248 22199-22289 24584-25975 HTEMP48 1279 767863 AL121747 7644   1-1738 HTEMP48 1279 767863 AL049761 7645   1-1738 HTEMP48 1279 767863 AL049761 7646  1-267 HTEMP49 1280 932319 AC005848 7647  1-50 276-606 3099-3179 3390-3458 4162-4388 HTEMR65 1281 909280 AC010547 7648   1-1542 HTEMU17 1286 789623 AL159141 7649  1-210 345-515 4335-4446 9330-9443 9841-9904 11140-12334 12776-13144 13501-13916 17369-18981 HTEMU17 1286 789623 AL118559 7650  1-369 HTEMU17 1286 789623 AL159141 7651  1-318 HTEMU17 1286 789623 AL118559 7652  1-416 HTEMU17 1286 789623 AL118559 7653  1-231 HTEMZ04 1290 927021 AC068707 7654  1-102 574-851 HTEMZ04 1290 927021 AC068707 7655  1-202 HTENB03 1292 923050 AL157814 7656  1-490 HTENB03 1292 923050 AL157814 7657  1-30 1784-1887 2320-2867 HTENB03 1292 923050 AL157814 7658  1-550 HTENC22 1293 775544 AC069539 7659  1-890  999-1314 1794-4625 HTENC22 1293 775544 AC069539 7660  1-416 HTENC22 1293 775544 AC069539 7661  1-129 HTENF08 1294 958378 AC018682 7662  1-752 HTENF08 1294 958378 AC018682 7663  1-252 HTENI58 1299 917213 AL121980 7664  1-716 HTENI58 1299 917213 AL121980 7665  1-179 373-573 HTENK69 1303 844557 AC063919 7666  1-696 1146-1317 1506-1768 HTENK69 1303 844557 AC073439 7667  1-696 1146-1317 1506-1768 HTENO50 1305 969213 AC009874 7668  1-315 1284-1411 1668-1749 3993-4056 4183-4346 5547-6161 6198-6612 6660-6806 7328-7394 7459-7881 8005-8503 8700-8977 9207-9362 10056-10514 12312-12436 HTENO50 1305 969213 AC009874 7669   1-1809 1985-2077 2851-7606 HTENP80 1307 775387 AL035453 7670  1-408 4407-4511 HTENP80 1307 775387 AL035453 7671  1-342 HTENQ05 1308 928244 AC024952 7672  1-126 1960-2212 2845-2947 6326-6450  9966-10000 12088-12311 13031-13145 13786-13869 14356-14874 HTENQ05 1308 928244 AC018638 7673  1-123 666-828 4839-5113 6402-6995 7727-7910 9744-9996 10630-10732 14112-14236 17737-17771 19858-20081 20801-20915 21556-21640 22127-22645 HTENQ05 1308 928244 AC024952 7674  1-368 HTENQ05 1308 928244 AC018638 7675  1-368 HTENQ05 1308 928244 AC018638 7676  1-374 HTENS22 1312 785996 AP001034 7677  1-964 1560-2151 HTENS22 1312 785996 AC015840 7678  1-965 1070-1278 1561-2152 HTENS22 1312 785996 AC015840 7679  1-422 HTENS43 1313 784936 AC011959 7680  1-189  439-1562 HTENS43 1313 784936 AF131216 7681  1-188  440-1562 HTENS91 1314 870515 AC016771 7682  1-688 HTENS91 1314 870515 AC048382 7683   1-1000 HTENS91 1314 870515 AC016771 7684  1-53 468-636 1619-1744 2423-2651 2790-3043 4364-4636 7345-7727 HTENS91 1314 870515 AC048382 7685  1-255 HTENX77 1317 771409 AP000484 7686   1-1719 HTENX77 1317 771409 AP000484 7687  1-255 HTENX77 1317 771409 AP000484 7688  1-103 2060-2420 4856-5151 HTENY35 1319 884043 AC006208 7689   1-1385 1465-3044 3323-3377 3821-3917 4057-4165 4748-4778 4805-5177 5224-5464 5956-6173 6207-7085 8138-8296 8758-9056 9162-9263 9638-9764 10225-10392 10853-11247 11548-12281 12417-12970 HTENY35 1319 884043 AC006208 7690   1-1425 1603-1678 1783-1875 2028-3154 3258-3740 3768-4488 4764-4913 5252-5382 5827-5905 6172-6319 6397-6466 6957-7076 7473-7606 8554-8608 8714-8741 8840-8984 HTEOF91 1329 918571 AL133387 7691   1-1187 HTEOF91 1329 918571 AL135794 7692   1-1189 HTEOF91 1329 918571 AL133387 7693  1-47 231-264 355-857 HTEOF91 1329 918571 AL135794 7694  1-146 HTEOF91 1329 918571 AL133387 7695  1-140 HTEOF91 1329 918571 AL135794 7696  1-47 231-264 355-857 HTEOK02 1332 918590 AL136084 7697  1-486 HTEOK02 1332 918590 AL136084 7698  1-181 2911-3377 HTEON67 1334 954114 AC004533 7699  1-347 HTEOU45 1335 915138 AC016309 7700  1-708 HTEOU45 1335 915138 AC016309 7701   1-1634 HTEOV90 1336 870532 AL359092 7702  1-116 HTEOV90 1336 870532 AC009453 7703  1-143 HTEOV90 1336 870532 AC025036 7704  1-148 HTEOV90 1336 870532 AC011953 7705  1-126 HTEOV90 1336 870532 AC027300 7706  1-158 HTEOV90 1336 870532 AC022231 7707  1-151 HTEOV90 1336 870532 AC023242 7708  1-86 HTEOV90 1336 870532 AC048342 7709  1-130 HTEOV90 1336 870532 AL121656 7710   1-2346 2487-3703 3832-4167 HTEOV90 1336 870532 AC048342 7711  1-118 HTEOW39 1338 870566 AL356464 7712  1-142 570-728 1523-1638 1741-1926 HTEOW39 1338 870566 AL356797 7713  1-142 570-728 1523-1638 1741-1926 HTEOW39 1338 870566 Z98304 7714  1-142 570-728 1523-1638 1742-1926 HTE0W39 1338 870566 AL356464 7715  1-538 HTEOW39 1338 870566 AL356464 7716  1-437 HTEOW39 1338 870566 AL356797 7717  1-136 HTEOW39 1338 870566 AL356797 7718  1-437 HTEOW39 1338 870566 Z98304 7719  1-538 HTEOW39 1338 870566 Z98304 7720  1-437 HTEPA08 1340 958391 AL133480 7721  1-918 1739-2284 2588-2821 HTEPA08 1340 958391 AC021645 7722  1-918 1739-2284 2588-2821 HTEPA08 1340 958391 AL133480 7723  1-640 HTEPA08 1340 958391 AL133480 7724  1-331 HTEPA08 1340 958391 AC021645 7725  1-331 HTEPA08 1340 958391 AC021645 7726  1-640 HTEPC76 1344 767824 AC008403 7727  1-270 797-964 1044-1123 1229-1342 1467-1845 2640-2987 3113-4431 4439-4555 5060-5233 5373-5488 6011-6410 6946-7068 7284-7513 8720-8791 8874-9044  9864-10381 10706-10846 12118-12821 12983-13117 13377-14044 14066-15218 16961-17324 HTEPC76 1344 767824 AC008403 7728   1-1468 HTEPC76 1344 767824 AC008403 7729  1-583 HTEPJ79 1352 774212 AC073569 7730  1-370 HTEPJ79 1352 774212 AC073595 7731  1-371 HTEPJ79 1352 774212 AC007949 7732  1-371 HTEPM33 1354 870561 AL132776 7733  1-42 1020-1195 2173-2338 6839-7029 11880-12103 HTEPM33 1354 870561 AL132776 7734  1-173 HTEPM33 1354 870561 AL132776 7735  1-791 HTEPM52 1355 806471 AC022744 7736  1-600 HTEPM52 1355 806471 AC009588 7737  1-600 HTEPM52 1355 806471 AC022744 7738  1-197 HTEPM52 1355 806471 AC009588 7739  1-86 404-641 1062-1413 1506-1869 2725-3045 3625-4106 HTEPP29 1358 917207 AC064831 7740  1-467 HTEPP29 1358 917207 AC023103 7741  1-470 HTEPP29 1358 917207 AC036199 7742  1-470 HTEPT25 1363 870509 AC074256 7743  1-408 HTEPZ10 1368 963433 AC011028 7744  1-543 HTEQB03 1370 922941 AC023331 7745  1-393 HTEQB03 1370 922941 AL358236 7746  1-391 HTEQB03 1370 922941 AL359374 7747  1-391 HTEQB03 1370 922941 AL358236 7748  1-220 HTEQB03 1370 922941 AC023331 7749  1-292 HTEQB03 1370 922941 AL359374 7750  1-116 130-210 HTEQB03 1370 922941 AL359374 7751  1-290 HTEQD40 1371 915198 AL121906 7752  1-158 414-924  975-1601 HTEQD40 1371 915198 AL121906 7753  1-776 856-949 1390-1468 1591-2048 2412-2463 2503-2918 3174-3270 HTEQD40 1371 915198 AL121906 7754  1-411 HTEQD69 1372 918579 AL157399 7755  1-712 HTEQD69 1372 918579 AC018476 7756  1-712 HTEQD69 1372 918579 AC007949 7757  1-711 HTEQD69 1372 918579 AC018476 7758  1-922 1159-1246 1288-1481 1547-1649 1673-1758 2026-2482 2668-3297 HTEQD69 1372 918579 AC018476 7759  1-145 541-677 1557-1852 HTEQD69 1372 918579 AC007949 7760  1-145 541-677 1555-1850 HTEQD69 1372 918579 AC007949 7761  1-314 HTEQJ42 1377 806495 AC007405 7762  1-510 HTEQO81 1378 806504 AC010766 7763  1-198 316-378 3441-3601 HTEQO81 1378 806504 AL163636 7764  1-198 316-378 3442-3602 HTEQO81 1378 806504 AL163195 7765  1-198 316-378 3442-3602 HTEQO81 1378 806504 AC010766 7766  1-301 HTEQO81 1378 806504 AC010766 7767  1-591 HTEQO81 1378 806504 AL163636 7768  1-591 HTEQO81 1378 806504 AL163636 7769  1-177 HTEQO81 1378 806504 AL163195 7770  1-293 HTEQO81 1378 806504 AL163195 7771  1-591 HTEQR94 1382 966486 AC010980 7772   1-1047 HTEQT63 1383 924799 AC026410 7773   1-1820 HTLAB44 1385 530579 AC006549 7774  1-530 HTLAB44 1385 530579 AC000097 7775  1-530 HTLAB44 1385 530579 AC006547 7776  1-530 HTLAB44 1385 530579 AC006549 7777  1-42 147-212 380-436 699-747  821-1197 HTLAB44 1385 530579 AC006549 7778  1-311 HTLAB44 1385 530579 AC000097 7779  1-42 147-212 380-436 699-747  821-1197 HTLAB44 1385 530579 AC000097 7780  1-311 HTLAB44 1385 530579 AC006547 7781  1-42 147-212 380-436 699-747  821-1197 HTLAB44 1385 530579 AC006547 7782  1-314 HTLAB73 1386 575019 AC000078 7783  1-341 2484-3046 3397-3489 4877-5165 5231-5303 5477-5578 6429-7030 7187-7509 7842-8148 HTLAB73 1386 575019 AC000078 7784  1-507 HTLAC81 1387 679414 AC019258 7785  1-200 HTLAC81 1387 679414 AP002807 7786  1-204 HTLAC81 1387 679414 AC034259 7787  1-204 HTLAD21 1389 761758 AC024029 7788  1-37 1140-1255 2004-2115 2586-2801 3347-3460 4242-4320 4959-5284 HTLAD21 1389 761758 AC019121 7789  1-37 1140-1249 2584-2799 3342-3460 4243-4321 4956-5281 HTLAD21 1389 761758 AC019121 7790  1-336 HTLAD21 1389 761758 AC024029 7791  1-336 HTLAV67 1392 530742 AC005258 7792  1-326 HTLAV67 1392 530742 AC005258 7793  1-278 HTLAV67 1392 530742 AC005258 7794  1-89 HTLBE55 1394 967408 AC010325 7795  1-78 167-227 346-440 HTLBF14 1396 971661 AC018638 7796  1-252 3348-3556 3720-3822 3877-4004 4927-5181 5226-5736 HTLBF14 1396 971661 AC018638 7797  1-130 HTLBG83 1397 527942 AP002840 7798  1-102 1010-1888 2064-2785 HTLBG83 1397 527942 AC016056 7799  1-290 HTLBG83 1397 527942 AC009466 7800  1-94 1419-1520 2428-3306 3482-4203 HTLBG83 1397 527942 AP000880 7801  1-94 1419-1520 2428-3306 3482-4203 HTLBG83 1397 527942 AC009466 7802  1-998 HTLBG83 1397 527942 AP002840 7803  1-368 HTLBG83 1397 527942 AP000880 7804  1-368 HTLBG83 1397 527942 AC009466 7805  1-368 HTLBG83 1397 527942 AP000880 7806  1-996 HTLCA95 1398 911655 AC012616 7807   1-1151 HTLCA95 1398 911655 AC012616 7808  1-284 HTLCX76 1400 767667 AC011736 7809  1-97 612-718  913-1065 5655-5767 6173-6351 6803-6954 9565-9706 13178-13360 13963-14058 17351-17653 19337-19476 22288-22405 22711-22769 24564-24601 25844-25947 26983-27370 28050-28233 29000-29163 HTLCX76 1400 767667 AC027618 7810  1-97 612-718  913-1065 5657-5768 6174-6352 6807-6958 9568-9709 13178-13216 HTLCX76 1400 767667 AC027618 7811  1-89 HTLCX76 1400 767667 AC011736 7812  1-152 HTLCX76 1400 767667 AC027618 7813  1-40 3350-3648 7546-7581 HTLCY27 1401 682208 AC021663 7814   1-1164 HTLCZ48 1403 572959 AC015497 7815  1-402 HTLCZ48 1403 572959 AL353695 7816  1-405 HTLCZ48 1403 572959 AC015497 7817  1-140 HTLCZ48 1403 572959 AL353695 7818  1-140 HTLCZ96 1404 815897 AL118498 7819  1-160 1685-1871 2742-2910 5414-5599 6883-6914 8226-8271 9277-9733 11311-11543 HTLDE64 1407 908613 AC005087 7820  1-207 524-773  945-1056 3251-3659 HTLDE64 1407 908613 AC005087 7821  1-232 HTLDE64 1407 908613 AC005087 7822  1-232 HTLDO94 1413 915223 AC053520 7823  1-163 1175-1361 1623-1701 1971-2071 2785-3328 HTLDO94 1413 915223 AC053520 7824  1-187 HTLDO94 1413 915223 AC053520 7825  1-216  490-1016 2053-2295 HTLDQ25 1415 870057 AL355315 7826   1-1401 HTLDQ25 1415 870057 AL359388 7827   1-1401 HTLDQ25 1415 870057 AL355315 7828  1-636 HTLDQ25 1415 870057 AL355315 7829  1-112 128-185 HTLDQ25 1415 870057 AL359388 7830  1-112 128-185 HTLDQ25 1415 870057 AL359388 7831  1-636 HTLDS55 1416 891322 AC020663 7832  1-64 584-868 2241-2367 2459-2539 4278-4416 4580-4698 4790-4886 8560-8662 9190-9487 10204-10263 10348-10678 HTLDS55 1416 891322 AC020663 7833  1-309 HTLDS55 1416 891322 AC020663 7834  1-304  849-1240 2947-3164 HTLDV31 1420 867748 AC022505 7835  1-547 HTLDZ14 1423 573401 AL133318 7836  1-403 HTLDZ14 1423 573401 AL133318 7837  1-353 HTLDZ14 1423 573401 AL133318 7838  1-381 HTLEB14 1424 573464 AL353647 7839   1-1046 1485-1639 HTLEB14 1424 573464 AL138784 7840   1-1046 1485-1639 HTLEB14 1424 573464 AC022786 7841   1-1046 1485-1639 HTLEB14 1424 573464 AL353647 7842  1-116 HTLEB14 1424 573464 AL138784 7843  1-116 HTLED72 1425 906989 AC011442 7844  1-281 HTLEG65 1427 870154 AC026083 7845   1-1655 HTLEG91 1428 870257 AL031406 7846  1-114 HTLEG91 1428 870257 Z94160 7847  1-114 HTLEG91 1428 870257 AL031406 7848  1-945 HTLEG91 1428 870257 Z94160 7849  1-945 HTLEI47 1430 573460 AC025959 7850  1-307 650-751 1100-1209 HTLEI47 1430 573460 AC009451 7851  1-307 650-751 1100-1209 HTLEI47 1430 573460 AC025963 7852  1-307 650-751 1100-1209 HTLEL01 1434 917022 AC024631 7853  1-496  699-1081 1222-1331 1385-1614 1658-1771 1784-2779 3025-3737 HTLEL01 1434 917022 AC053481 7854  1-84 142-371 415-528  541-1535 1780-2492 3204-3300 3678-5015 HTLEL01 1434 917022 AC027821 7855  1-50 213-300  859-1126 1195-1903 2104-2487 2628-2737 2791-3020 3064-3182 3190-4185 4433-5145 5857-5953 6331-7971 7973-8232 8452-8515 HTLEL01 1434 917022 AC036181 7856  1-84 141-370 414-532  540-1535 1776-2488 3200-3296 3674-5593 5809-6696 HTLEL01 1434 917022 AC036181 7857  1-524 687-774 1333-1600 1669-2377 2578-2962 3103-3212 3266-3495 3539-3657 3665-4659 4905-5617 6332-6428 6806-8442 8444-8703 8918-9805 HTLEL01 1434 917022 AC023133 7858  1-524 688-775 1333-1600 1669-2321 2574-2957 3098-3207 3261-3490 3534-3652 3660-4655 4896-5608 6320-6416 6792-8432 8434-8693 8908-9796 HTLEL01 1434 917022 AC067923 7859  1-104 267-354  913-1180 1249-1956 2157-2540 2681-2790 2844-3073 3117-3235 3243-4238 4484-5196 5908-6004 6382-8301 8517-9404 HTLEL01 1434 917022 AC015818 7860  1-940 HTLEL01 1434 917022 AC003976 7861  1-524 688-775 1334-1601 1670-2378 2579-2962 3103-3212 3266-3495 3539-3657 3665-4659 4905-5617 6332-6428 6806-8442 8444-8703 8918-9804 HTLEL01 1434 917022 AC021317 7862  1-529 HTLEL01 1434 917022 AC036181 7863  1-358 HTLEL01 1434 917022 AC053481 7864  1-297 HTLEL01 1434 917022 AC036181 7865  1-371 HTLEL01 1434 917022 AC036181 7866  1-371 HTLEL01 1434 917022 AC023133 7867  1-243 HTLEL01 1434 917022 AC036181 7868  1-243 HTLEL01 1434 917022 AC023133 7869  1-371 HTLEL01 1434 917022 AC067923 7870  1-371 HTLEL01 1434 917022 AC015818 7871  1-527 HTLEL01 1434 917022 AC015818 7872  1-554 559-639 HTLEL01 1434 917022 AC003976 7873  1-371 HTLEL01 1434 917022 AC003976 7874  1-243 HTLEL01 1434 917022 AC021317 7875   1-1419 1443-1741 1748-2500 HTLEL01 1434 917022 AC021317 7876  1-103 HTLEL07 1436 953712 AC015936 7877  1-85 1216-1369 1748-1880 2593-3004 3388-3920 4277-5617 HTLEL07 1436 953712 AC015936 7878   1-1765 2427-2527 3995-4672 4991-5033 5608-5837 6046-6184 6451-6567 7324-7820 8101-8200 8402-8463 9279-9875 HTLEL31 1437 669950 AF053356 7879  1-71 234-304 320-826  878-1099 1233-1683 2077-3297 HTLEL31 1437 669950 AF053356 7880  1-434 HTLEL31 1437 669950 AF053356 7881  1-152 HTLEQ07 1441 953706 AC009485 7882  1-159 352-455 634-742 1105-1433 HTLEQ07 1441 953706 AC009485 7883  1-550 HTLES54 1443 574884 AC007732 7884  1-694 HTLES54 1443 574884 AC007732 7885  1-102 HTLES54 1443 574884 AC007732 7886   1-1969 HTLET56 1444 911654 AL356984 7887   1-1371 HTLET78 1445 836820 AC048358 7888  1-64 135-253 439-619  880-1007 1334-1548 1691-2473 HTLET78 1445 836820 AC027307 7889  1-64 135-253 439-619  880-1007 1335-1549 1692-2474 HTLET78 1445 836820 AC027307 7890  1-80 HTLET93 1446 573454 AC021744 7891  1-105 HTLEV33 1447 527956 AC024257 7892   1-1156 HTLEV33 1447 527956 AC024257 7893  1-496 HTLEV33 1447 527956 AC024257 7894  1-529 HTLEW12 1449 870255 AC069004 7895   1-1937 HTLEW12 1449 870255 AC069004 7896  1-744 HTLEW21 1450 573458 AC008392 7897  1-80 1758-1900 3780-4202 4434-4597 4677-4747 HTLEW21 1450 573458 AC027218 7898  1-80 1754-1896 3776-4198 4430-4593 4673-4743 HTLEW21 1450 573458 AC027218 7899  1-872 HTLEW21 1450 573458 AC008392 7900  1-872 HTLEY11 1451 967309 AC036174 7901  1-88 1369-1453 2944-3069 3655-4026 HTLEZ14 1453 791662 AC006549 7902  1-530 HTLEZ14 1453 791662 AC000097 7903  1-530 HTLEZ14 1453 791662 AC006547 7904  1-530 HTLEZ14 1453 791662 AC006549 7905  1-42 147-212 380-436 699-747  821-1197 HTLEZ14 1453 791662 AC006549 7906  1-311 HTLEZ14 1453 791662 AC000097 7907  1-42 147-212 380-436 699-747  821-1197 HTLEZ14 1453 791662 AC000097 7908  1-311 HTLEZ14 1453 791662 AC006547 7909  1-42 147-212 380-436 699-747  821-1197 HTLEZ14 1453 791662 AC006547 7910  1-314 HTLEZ15 1454 934288 AC021163 7911  1-212 773-858 1055-1178 HTLEZ15 1454 934288 AC011495 7912  1-210 774-859 1056-1155 HTLEZ15 1454 934288 AC021163 7913  1-150 HTLEZ15 1454 934288 AC021163 7914  1-334 HTLEZ15 1454 934288 AC011495 7915  1-150 HTLEZ15 1454 934288 AC011495 7916  1-325 HTLFC20 1457 917128 AL354944 7917  1-116 1049-1279 1947-2369 2924-3064 3498-9096 10048-10150 10917-11052 11221-11920 12125-12310 12501-12633 12868-13122 13980-14176 16118-16486 16537-17101 17616-18267 18312-19168 20650-20901 21433-21866 23387-23568 23660-23748 HTLFC20 1457 917128 AL354944 7918  1-259 HTLFC20 1457 917128 AL354944 7919  1-101 HTLGD25 1465 870136 AC025865 7920   1-1491 HTLGD25 1465 870136 AC019225 7921   1-1491 HTLGD25 1465 870136 AL160006 7922   1-1491 HTLGD25 1465 870136 AC019225 7923  1-480 HTLGD25 1465 870136 AC025865 7924  1-481 HTLGD25 1465 870136 AL160006 7925  1-481 HTLGD69 1466 835493 AC013713 7926   1-1128 HTLGD69 1466 835493 AL157875 7927   1-1128 HTLGD69 1466 835493 AC013713 7928  1-362 5379-5440 HTLGD69 1466 835493 AC013713 7929  1-493 HTLGD69 1466 835493 AL157875 7930  1-362 5379-5440 HTLGM07 1470 952254 AC003688 7931  1-81 236-691  773-1054 1662-1893 2248-2282 3053-3219 3774-4061 4238-4344 4469-4939 5460-5564 5664-6980 HTLGM07 1470 952254 AC003688 7932  1-85 509-995 1324-1425 1574-1640 HTLGM07 1470 952254 AC003688 7933  1-265 HTLHE72 1475 963471 AL353608 7934  1-510 HTLHE72 1475 963471 AL353608 7935  1-628 HTLHE72 1475 963471 AL353608 7936  1-907 HTLHL82 1476 958334 AL162377 7937  1-246 3348-4249 HTLHO94 1477 968685 AC006445 7938   1-1321 HTLHP80 1480 870156 AL132868 7939  1-784 HTLHP80 1480 870156 AL132868 7940  1-135 HTLIK11 1489 966043 AC008649 7941  1-504 1236-1319 2515-2917 4549-4998 5053-5186 5694-5778 6477-6722 9052-9536 9591-9714 9993-10115 HTLIK11 1489 966043 AC008649 7942  1-370 376-776 HTLIP19 1490 958351 AC018595 7943  1-147 393-578 1688-1771 4090-4246 4573-4704 5143-5249 6244-6312 6446-6554 6763-6903 HTLTP19 1490 958351 AC018595 7944  1-140 HTL1Y52 1495 942161 AC011448 7945  1-194  424-1198 1938-2018 3137-3317 5423-5732 5894-6019 6299-6608 7425-7771 8216-8713 9697-9815 9872-9959 10811-11127 11264-11754 11867-12454 12539-13980 14020-14373 14522-15107 15641-15786 18585-22176 22246-22801 24994-25641 26099-26401 28795-29074 29176-29432 29653-29854 31298-31468 31507-32203 32864-33359 34805-34936 35464-35750 35878-36319 36610-37065 37680-38123 38902-39124 42685-42993 43593-43745 47682-47911 48694-49237 49352-49706 52310-52618 53725-54348 54650-55016 56425-56525 56655-57164 58248-59197 59662-60112 60732-61475 62024-62173 69325-69730 HTLIY52 1495 942161 AC011448 7946  1-544 HTL1Y52 1495 942161 AC011448 7947  1-293 HTLJA24 1497 934279 AC006237 7948  1-77 1994-2263 3098-3450 3551-4203 HTLJA24 1497 934279 AC006237 7949   1-1048 1633-2065 2080-2333 2374-2524 4212-4459 5299-5463 7313-7346 HTLJA24 1497 934279 AC006237 7950  1-101 HTLJC71 1498 922923 AC009516 7951   1-2009 HTLJC71 1498 922923 AC007957 7952   1-1747 HTLJC71 1498 922923 AC018751 7953   1-2009 HTLJC71 1498 922923 AC023490 7954   1-2009 HTLJC71 1498 922923 AC009516 7955  1-375 HTLJC71 1498 922923 AC009516 7956  1-494 HTLJC71 1498 922923 AC007957 7957  1-205 HTLJC71 1498 922923 AC018751 7958  1-494 HTLJC71 1498 922923 AC023490 7959  1-375 HTLJC71 1498 922923 AC018751 7960  1-375 HTLJJ75 1501 924755 AL354888 7961   1-1283 HTLJJ75 1501 924755 AL033527 7962  1-448  451-1733 HTLJJ75 1501 924755 AL354888 7963  1-699 HTLJJ75 1501 924755 AL033527 7964  1-696 HTLJL23 1502 922994 AL031587 7965  1-151 441-552 1214-1667 1820-2290 2375-2664 4552-5062 5224-5492 6136-6319 6684-7594 7786-8096 8297-8930  8932-10855 HTLJL23 1502 922994 AL031587 7966  1-135 2617-2705 3232-3371 5671-5793 HTTAD55 1503 835652 AC021558 7967  1-260 HTTAD55 1503 835652 AC021558 7968  1-599 HTTAE49 1504 723331 AC023266 7969  1-491 HTTAE49 1504 723331 AC023266 7970  1-276 HTTAE49 1504 723331 AC023266 7971   1-1777 HTTAJ35 1506 707750 AC022650 7972  1-77 3371-4503 HTTAJ35 1506 707750 AC022650 7973  1-273 HTTAJ50 1507 509657 AC022148 7974  1-287 HTTAJ50 1507 509657 AC022148 7975  1-392 HTTAN57 1508 509453 AC010299 7976  1-304 HTTAS96 1509 961057 AC074073 7977  1-254 HTTAS96 1509 961057 AC022621 7978  1-320 HTTAS96 1509 961057 AC022621 7979  1-272 HTTAS96 1509 961057 AC022621 7980  1-195 HTTAU82 1510 797726 AC009618 7981  1-342 HTTAU82 1510 797726 AL390022 7982  1-510 HTTAU82 1510 797726 AC006517 7983  1-191 443-741 2568-2781 3248-3544 3716-3884 HTTAU82 1510 797726 AL137226 7984  1-342 HTTAU82 1510 797726 AL139165 7985  1-342 HTTAU82 1510 797726 AC006927 7986  1-191 443-741 2568-2778 3317-3427 3717-3885 HTTAU82 1510 797726 AC009618 7987  1-731 HTTAU82 1510 797726 AL390022 7988  1-728 HTTAU82 1510 797726 AC006517 7989  1-115 HTTAU82 1510 797726 AL390022 7990  1-383 HTTAU82 1510 797726 AC006517 7991  1-76 848-890 1618-2210 HTTAU82 1510 797726 AL137226 7992  1-731 HTTAU82 1510 797726 AL139165 7993  1-731 HTTAU82 1510 797726 AC006927 7994  1-89 HTTAU82 1510 797726 AC006927 7995  1-76 848-890 1618-2210 HTTBH34 1512 530565 AC008883 7996   1-1480 1521-2216 HTTBH34 1512 530565 AC008401 7997  1-103 795-938 1928-3094 HTTBH34 1512 530565 AC008905 7998  1-527 1329-1594 2331-2573 2841-2943 3635-3778 4769-6401 6442-7129 HTTBH34 1512 530565 AC008865 7999  1-76 1854-2048 4402-4492 5258-5784 6586-6851 7588-7830 8098-8200 8892-9035 10026-11658 11699-12384 HTTBH34 1512 530565 AC008883 8000  1-144 HTTBH34 1512 530565 AC008401 8001  1-244 HTTBH41 1513 530562 AL133215 8002  1-747  955-1885 2072-2316 2864-3486 4259-4395 4625-4789 5237-6834 HTTBH41 1513 530562 AL133215 8003  1-458 HTTBH41 1513 530562 AL133215 8004  1-187 316-492 663-724  870-1310 2217-2658 2795-3946 3989-5369 5762-6797 6802-6998 HTTBH54 1514 530563 AC013443 8005  1-305 HTTBJ94 1515 530564 AC012306 8006  1-371 2517-2948 3269-3389 4036-4139 4655-4747 6026-6302 6920-7056 7205-7304  8993-12574 HTTBN67 1516 578085 AF235102 8007  1-227 HTTBN67 1516 578085 AF235102 8008  1-117 290-371 1962-2328 HTTCA15 1517 869705 AC005833 8009  1-412 HTTCA15 1517 869705 AC005833 8010  1-559 HTTCD71 1519 530393 AL049844 8011  1-74 381-637 1227-1614 1677-3333 4088-4213 4220-4876 5053-5406 5474-5917 6045-6442 HTTCD71 1519 530393 AL049844 8012  1-263 HTTCD71 1519 530393 AL049844 8013  1-885 HTTCL35 1520 529672 AC024375 8014  1-253 1273-1795 HTTCL35 1520 529672 AC024375 8015  1-418 HTTDF50 1522 526385 AC022335 8016   1-1306 HTTDF50 1522 526385 AC022335 8017  1-156 HTTDI21 1525 869686 AC074236 8018  1-485 HTTDI21 1525 869686 AC009269 8019  1-192 206-468 1229-1713 2228-2407 2998-3211 3314-3817 4343-4938 5571-5768 HTTDI21 1525 869686 AC009269 8020  1-104 HTTDI21 1525 869686 AC009269 8021  1-559 HTTDL45 1528 523452 AC007390 8022  1-75 417-583 1679-1765 2788-3466 4413-4490 4941-5105 5400-5517 6071-6185 8399-8718  9893-10500 HTTDL45 1528 523452 AC007390 8023  1-803 HTTDL45 1528 523452 AC007390 8024  1-186  901-2187 2559-2605 2853-4188 4215-6320 6739-7105 7892-8398 8852-9356  9561-10277 10360-10560 12504-12595 13356-13552 13845-13905 15014-15064 15377-15953 16401-16466 16831-17031 17378-18339 18502-18552 19127-19426 19501-19804 20934-21502 21567-21695 21900-21988 22836-23379 23660-23743 23890-24076 24682-24916 26831-27787 28708-30551 32927-33109 HTTDL89 1529 959837 AC004803 8025  1-376 HTTDL89 1529 959837 AC004765 8026  1-376  471-1538 2707-3361 HTTDL89 1529 959837 AC004803 8027   1-1068 HTTDL89 1529 959837 AC004803 8028   1-2019 3153-3257 3637-3880 4449-4655 4695-4983 5401-6067 7497-7573 8470-8588 8874-9327  9904-10065 11619-11681 12466-12581 12911-13213 14830-14911 16048-17861 17889-18018 18305-18362 18566-18740 19076-19167 HTTDL89 1529 959837 AC004765 8029  1-264 HTTDN85 1531 783444 AC078852 8030  1-442 HTTDN85 1531 783444 AC022763 8031  1-443 HTTDN85 1531 783444 AC078852 8032  1-538 HTTDN85 1531 783444 AC022763 8033  1-538 HTTDR91 1534 790336 AC005740 8034  1-176 1646-1818 4524-4697 5747-5899 8660-9945 10558-10883 11064-11295 11314-11646 14324-14496 15739-15886 16611-16794 18676-21241 22938-23085 23224-24224 24447-24843 25199-25490 25515-27062 HTTDR91 1534 790336 AC005740 8035  1-540 HTTDR91 1534 790336 AC005740 8036  1-398 HTTDR92 1535 573666 AC023098 8037  1-368 HTTDR92 1535 573666 AC003046 8038  1-368 HTTDR92 1535 573666 AC023098 8039  1-368 HTTDR92 1535 573666 AC023098 8040  1-62 1717-2020 2315-2432 3271-3381 4686-4832 HTTDR92 1535 573666 AC003046 8041  1-62 1728-2020 2315-2432 3271-3381 4686-4832 HTTDR92 1535 573666 AC003046 8042  1-368 HTTDS02 1536 920589 AL139100 8043  1-309 2987-3113 4207-4877 5573-5677 5684-5845 9382-9495 11034-11269 14694-14786 16010-16116 16799-17013 17078-17196 18023-18134 19046-19565 20157-20645 HTTDS02 1536 920589 AL139100 8044  1-121 HTTDX84 1537 921100 AC016912 8045  1-137  839-1199 4679-4860 HTTDX84 1537 921100 AC018682 8046  1-137  840-1200 4680-4861 HTTDZ91 1539 523206 AL137229 8047  1-145 572-661 4888-5112 6942-7339 7820-7914 8041-8423 8957-9106 11434-11806 11986-12491 13542-13680 14277-16062 HTTDZ91 1539 523206 AL137229 8048   1-1790 HTTEH58 1541 747943 AC068781 8049  1-387 HTTEH58 1541 747943 AC068365 8050  1-387 HTTEH58 1541 747943 AC073466 8051  1-387 HTTEH58 1541 747943 AC068365 8052  1-813 HTTEH58 1541 747943 AC073466 8053  1-813 HTTEH58 1541 747943 AC068781 8054  1-813 HTTEL50 1542 745985 AL359551 8055  1-443 HTTEL50 1542 745985 AL360010 8056  1-227 3577-4019 4331-4797 HTTEL50 1542 745985 AL360010 8057  1-556 HTTEV62 1544 573614 AC018706 8058  1-120 327-596 HTTEY64 1545 974107 AL121759 8059  1-457 HTTEY64 1545 974107 AL121759 8060  1-182 1815-1886 HTTEY64 1545 974107 AL121759 8061  1-413 HTTEY67 1546 917903 AC012467 8062  1-174 339-486 2042-2214 3686-3797 4399-4507 4767-4939 5440-5530 5625-5731 6070-6204 7501-7716 7788-7943 8041-8340 9024-9118 9626-9767 10655-10995 11935-12314 12866-13125 13129-15725 15843-17466 17604-18286 18317-18594 18649-19313 20121-20283 20736-23161 23235-23790 23989-24537 25167-25310 26353-26806 26813-26872 27021-27163 29155-29282 30027-30154 32358-32499 35505-35567 HTTEY67 1546 917903 AC012467 8063  1-150 3016-3145 3424-3525 4978-5073 5533-5878 6004-6106 6241-7612 7874-8710 HTTEY67 1546 917903 AC012467 8064  1-527 HTTEZ34 1547 771602 AL356116 8065  1-508 HTTEZ34 1547 771602 AC017067 8066  1-244 4587-5158 5672-6138 HTTEZ34 1547 771602 AL356116 8067  1-467 HTTFA16 1548 870198 AC067749 8068  1-81  610-1275 1444-1660 1750-2267 2590-3070 3195-3769 3824-4507 4543-4871 4996-6355 6426-6973 6998-7524 HTTFA16 1548 870198 AC067749 8069  1-360 HTTFB60 1549 869666 AC023818 8070   1-2041 2271-2442 2475-6107 HTTFB60 1549 869666 AC023818 8071  1-353 HTTFB60 1549 869666 AC023818 8072  1-120 HTTFG35 1550 778426 AC019205 8073  1-231 428-607 HTTFG35 1550 778426 AL133336 8074  1-231 428-607 HTTFG35 1550 778426 AC068247 8075  1-231 428-607 HTTFG35 1550 778426 AC019205 8076  1-974 HTTFG35 1550 778426 AL133336 8077  1-974 HTTFG35 1550 778426 AC068247 8078  1-974 HTTFG83 1551 974284 AL137128 8079  1-693 HTTFG83 1551 974284 AL137128 8080  1-413 HTTFL89 1554 974346 AC005551 8081  1-436 HTTFL89 1554 974346 AC005551 8082  1-135 1535-1715 2043-2114 5528-6140 HTTFM17 1555 750942 AC009994 8083  1-422  658-1260 2947-3758 HTTFM17 1555 750942 AC009994 8084  1-155 HTTFS59 1557 825922 AP001332 8085   1-1736 1937-2284 2596-2760 3034-3162 4857-4934 5196-5338 6131-6244 6276-6756 7170-7308 7537-7569 7659-7709 HTTFS59 1557 825922 AC013606 8086   1-1738 1938-2285 2478-2580 2594-2758 3036-3160 HTTFS59 1557 825922 AC015685 8087   1-1737 HTTFS59 1557 825922 AC013606 8088  1-489 HTTFS59 1557 825922 AC015685 8089  1-487 HTTFT08 1558 934460 AC013726 8090  1-43 317-418 1097-2127 2193-2346 2456-2503 2713-3159 3231-6093 HTTFT08 1558 934460 AC013726 8091  1-536 HTTFV93 1559 925544 AL139410 8092   1-1222 1338-1532 HTTFV93 1559 925544 AL353760 8093   1-1222 1338-1532 HTTFW03 1560 923105 AC006566 8094  1-472 HTTFX21 1561 924775 AC026210 8095   1-1869 HTTFX21 1561 924775 AC026210 8096  1-150 HTTFZ70 1562 974066 AL355594 8097  1-115 207-368 516-876 1441-1565 2014-2187 2404-2951 3705-5973 6008-8387 HTTFZ70 1562 974066 AL033383 8098   1-1004 2982-3105 3372-3514 4034-4609 5643-5817 9019-9176 10736-10817 12053-12475 13292-13391 14259-14546 15423-15497 16340-16660 17244-17630 17683-17864 17981-18128 18264-18585 18678-18767 20206-20356 20955-21122 22834-23358 23679-23944 24217-24406 24565-24684 25085-25439 26585-26758 26975-27139 28275-30550 30582-33232 36611-37091 37344-38113 46301-46465 55718-55969 66431-66687 HTTFZ70 1562 974066 AL138831 8099   1-1004 2982-3105 3372-3514 4034-4609 5643-5817 9019-9176 10736-10817 12053-12475 13292-13391 14259-14546 15423-15497 16340-16660 17244-17630 17683-17864 17981-18128 18264-18585 18678-18767 20206-20356 20955-21122 22836-23360 23681-23946 24219-24408 24567-24686 24778-24939 25087-25441 26585-26758 26975-27139 28275-30550 30582-33232 36611-37091 37344-38113 46301-46465 55718-55969 66431-66687 HTTFZ70 1562 974066 AL033383 8100  1-375 HTTFZ70 1562 974066 AL355594 8101  1-266 539-728 HTTFZ70 1562 974066 AL033383 8102  1-205 HTTFZ70 1562 974066 AL138831 8103  1-375 HTTFZ70 1562 974066 AL138831 8104  1-205 HTTHU43 1564 953479 AC008393 8105   1-1033 HTTHU43 1564 953479 AC010285 8106   1-1031 HTTHU43 1564 953479 AC010313 8107   1-1032 HTTHU43 1564 953479 AC010313 8108  1-217 1839-2045 2948-3521 3767-4083 5131-6402 6992-7292 8101-8167 HTTHU43 1564 953479 AC008393 8109  1-401 HTTHU43 1564 953479 AC010285 8110  1-401 HTTIG04 1565 926752 AC012609 8111  1-458 HTTIG04 1565 926752 AC026406 8112  1-458 HTTIG04 1565 926752 AC012609 8113  1-661 HTTIG04 1565 926752 AC026406 8114  1-661 HTTIH23 1566 869636 AC040970 8115   1-1041 1186-1881 2845-2973 HTTIH23 1566 869636 AC011676 8116   1-1041 1185-1880 2844-2972 5523-5631 6840-7111 7196-7890 8274-9038  9916-10234 HTTIH23 1566 869636 AC040970 8117  1-740 HTTIH23 1566 869636 AC011676 8118  1-400 HTTIH80 1567 869635 AC006443 8119  1-385 HTTIH80 1567 869635 AC006443 8120  1-201 HTTIN23 1569 869634 AC002549 8121  1-566 HTTIU05 1570 931015 AC008663 8122  1-461 3399-3527 4652-5129 5447-6031 6123-6401 6651-7418 8095-9142 HTTIU05 1570 931015 AC010339 8123  1-76 1203-1680 1998-2582 2674-2952 3202-3969 4646-5693 HTTIU05 1570 931015 AC022259 8124  1-585 HTTTU05 1570 931015 AC008663 8125  1-101 HTTTU05 1570 931015 AC008663 8126  1-130 HITTU05 1570 931015 AC010339 8127  1-130 HITUJ05 1570 931015 AC022259 8128  1-478 HTTUJ05 1570 931015 AC022259 8129  1-280 HTTIW81 1571 922817 AL357149 8130  1-433 HTTIW81 1571 922817 AL357149 8131  1-399 HTTIZ05 1572 930994 AC012246 8132  1-443 HTTIZ05 1572 930994 AC012246 8133  1-646 HTTJA11 1573 839725 AC068403 8134  1-440 HTTJA11 1573 839725 AC067775 8135  1-440 HTTJA11 1573 839725 AC068403 8136  1-288 HTTJA11 1573 839725 AC067775 8137  1-288 HTTJA47 1574 869618 AP002091 8138  1-276 3023-3207 HTTJA47 1574 869618 AP002091 8139  1-149 HTTJA47 1574 869618 AP002091 8140  1-179 HTTJH13 1575 869615 AC013436 8141  1-324 HTTJH13 1575 869615 AC004859 8142  1-324 HTTJH13 1575 869615 AC013436 8143  1-209 HTTJH13 1575 869615 AC013436 8144  1-65 191-304 339-660 712-888 HTTJH13 1575 869615 AC004859 8145  1-209 HTTJH13 1575 869615 AC004859 8146  1-65 191-304 339-660 712-888 HTTJM01 1576 913799 AC009469 8147  1-310 383-487 HTTJQ06 1577 934130 AC022202 8148   1-1086 HTTJQ06 1577 934130 AL136969 8149  1-308  973-1308 4938-4961 8196-8326 11508-12593 13039-13501 15003-15234 17040-17530 20304-20729 25068-25578 25828-26705 26728-26816 26831-27320 28927-29311 29405-29614 30437-31474 HTTJQ06 1577 934130 AC022202 8150  1-461 HTTJQ06 1577 934130 AL136969 8151  1-98 HTTJQ06 1577 934130 AL136969 8152  1-377 HTTJX68 1578 974063 AC026318 8153  1-312  987-1439 3651-3801 HTTJX68 1578 974063 AC023910 8154  1-453 HTTJX68 1578 974063 AC026318 8155  1-241 HTTJX68 1578 974063 AC026318 8156  1-218 HTTJY08 1579 958170 AL355586 8157  1-453 HTTJY08 1579 958170 AL355307 8158  1-453 HTTJY08 1579 958170 AL023584 8159  1-453 HTTJY08 1579 958170 AL355586 8160  1-349 HTTJY08 1579 958170 AL355307 8161  1-349 HTTJY08 1579 958170 AL023584 8162  1-349 HTTKF89 1581 960928 AL035425 8163  1-524 HTTKF89 1581 960928 AL035425 8164  1-133 HTTKF89 1581 960928 AL035425 8165  1-418 HTTKK06 1583 974311 AC046137 8166   1-1282 1645-2164 3070-3680 3888-3943 3999-4329 5064-5333 6343-6658 6733-6987 7096-7247 7432-7831 8006-8123 8293-8756 9804-9858 HTTKK06 1583 974311 AL138965 8167   1-1284 1646-2165 3071-3681 3889-3944 4000-4499 5065-5333 6343-6662 6733-6987 7096-7247 7432-7831 8006-8123 8293-8756 9803-9857 HTTRL80 1584 974316 AC027572 8168  1-495 HTTKN21 1585 974310 AC024563 8169  1-495 HTTKN21 1585 974310 AC010318 8170  1-495 HTTKN21 1585 974310 AC008626 8171  1-495 HTTKN21 1585 974310 AC024563 8172  1-276 HTTKN21 1585 974310 AC010318 8173  1-276 HTTKN21 1585 974310 AC008626 8174  1-276 HTTKS13 1588 926795 AC023593 8175  1-494 HTTKS13 1588 926795 AC012406 8176  1-195 510-647 1298-1791 2210-2419 2689-2911 3871-4132 4236-4418 5740-5922 9461-9715 10556-10634 HTTKS13 1588 926795 AC023593 8177  1-207 480-702 1662-1923 NTTKS13 1588 926795 AC012406 8178  1-87 NTTKV17 1589 830008 AC005027 8179  1-993 2319-3110 3184-3327 3609-3791 4475-4927 8332-9120 9164-9583 10780-11193 12543-14416 HTTKV17 1589 830008 AC005027 8180   1-2780 HUDAM29 1590 529157 AL161451 8181  1-354 HUDAM29 1590 529157 AL161451 8182  1-238 HUDBZ78 1591 739638 AC018638 8183  1-123 666-828 4839-5113 6402-6995 7727-7910 9744-9996 10630-10732 14112-14236 17737-17771 19858-20081 20801-20915 21556-21640 22127-22645 HUDBZ78 1591 739638 AC018638 8184  1-368 HUDBZ78 1591 739638 AC018638 8185  1-374 HUKAA62 1592 503626 AC009789 8186  1-298 HUKAA62 1592 503626 AC009789 8187  1-166 HUKAC72 1594 966804 AC040933 8188  1-747 1785-1982 2445-2506 3235-3323 3868-4360 7129-7364 8883-9903 HUKAC72 1594 966804 AC040933 8189  1-431 HUKAM82 1595 954420 AL096865 8190  1-323 HUKAX07 1596 954359 AL355773 8191  1-294 HUKCC86 1597 529727 AL359388 8192  1-226 HUKCC86 1597 529727 AL359388 8193  1-168 HUKDH28 1598 531165 AC006055 8194  1-975 1001-1658 3268-3377 5231-5317 5881-6170 6180-6546 6750-10147 10463-11127 HUKDH28 1598 531165 AC006055 8195  1-344 HUKDH50 1599 531163 AL157414 8196  1-356 HUKEH36 1600 531110 AC009753 8197  1-279 1685-1909 3546-3709 5906-6035 6290-6604 6687-6845 9440-9473 16009-16296 20083-20229 20650-20784 22152-22256 27158-27662 27907-28244 28359-28661 30187-30275 31177-31379 31668-32105 33142-33243 38066-38199 40117-40592 45086-45120 HUKEH36 1600 531110 AC009851 8198  1-201 752-1089 1204-1522 3032-3120 4022-4224 4513-4950 5988-6089 10911-11044 12962-13437 17931-17965 HUKEH36 1600 531110 AC009753 8199  1-101 HUKEH36 1600 531110 AC009753 8200  1-944 HUKEH36 1600 531110 AC009851 8201  1-944 HUKEH50 1601 531108 AC018782 8202  1-52 517-603  785-1153 HUKEH50 1601 531108 AC024575 8203  1-52 518-604  785-1153 HUKEH50 1601 531108 AC008481 8204  1-52 517-603  784-1152 HUKEH50 1601 531108 AC024575 8205  1-115 1178-1315 1730-1957 2076-2562 2638-2854 HUKEH50 1601 531108 AC008481 8206  1-40 503-612 1674-1811 2224-2446 2570-3053 3134-3271 HUKEK55 1602 522213 AL136295 8207  1-329  621-1000 1739-2035 2395-3026 3192-5637 5774-6952 7033-7120 7249-7328 7415-7456 7876-8005 8093-8272 8521-8588 8691-8796 8883-8960 9217-9387 9492-9542 9701-9811 10103-10210 10357-10490 10690-10805 10909-11022 11253-11376 11565-11674 11773-11883 11999-12082 12157-12216 12317-12421 12502-12696 12828-12881 12913-13134 13225-13394 13509-13717 13829-13964 14050-14163 14402-14637 14749-15004 15091-16277 16464-17066 17139-18207 18288-18319 18465-18527 18767-18851 18893-19292 19548-20127 22009-22378 22471-22544 22627-24028 HUKEK55 1602 522213 AL136295 8208  1-290 HUKEK55 1602 522213 AL136295 8209  1-102 HUKES11 1604 967604 AL358433 8210  1-339 HUKES11 1604 967604 AL358433 8211   1-2038 HUKES11 1604 967604 AL358433 8212  1-368 HUKFL69 1605 526819 AL365510 8213  1-392 HUKFL69 1605 526819 AC009564 8214  1-392 HUNAD94 1608 575299 AC024403 8215  1-115 HUNAD94 1608 575299 AL133238 8216  1-353 HUVBB90 1609 503042 AC020611 8217  1-340 HUVBB90 1609 503042 AC020611 8218  1-313 880-916 HUVBB93 1610 502903 AL121603 8219  1-279 HUVCS14 1614 914768 AC011448 8220  1-194  424-1198 1938-2018 3137-3317 5423-5732 5894-6019 6299-6608 7425-7771 8216-8713 9697-9815 9872-9959 10811-11127 11264-11754 11867-12454 12539-13980 14020-14373 14522-15107 15641-15786 18585-22176 22246-22801 24994-25641 26099-26401 28795-29074 29176-29432 29653-29854 31298-31468 31507-32203 32864-33359 34805-34936 35464-35750 35878-36319 36610-37065 37680-38123 38902-39124 42685-42993 43593-43745 47682-47911 48694-49237 49352-49706 52310-52618 53725-54348 54650-55016 56425-56525 56655-57164 58248-59197 59662-60112 60732-61475 62024-62173 69325-69730 HUVCS14 1614 914768 AC011448 8221  1-544 HUVCS14 1614 914768 AC011448 8222  1-293 HUVCU71 1615 968663 AC005410 8223  1-26 2590-2889 3602-3771 4339-5017 6295-6485 6909-6998 7521-8143 8433-8529 9637-9899 10563-10925 11304-11768 12104-12617 13487-13648 13989-14159 15246-15413 15996-16140 16890-17029 18712-20020 HUVCU71 1615 968663 AC005410 8224   1-1213 1372-2983 3192-3439 4265-5250 HUVCW62 1616 535361 AL139384 8225  1-399 HUVCW62 1616 535361 AL139384 8226  1-245 HUVCW62 1616 535361 AL139384 8227  1-115 HUVDB28 1617 535006 AL078634 8228  1-139 234-735 1948-2046 6359-6449 8088-8267 11305-11788 11843-11990 12405-12744 HUVDB28 1617 535006 AL078634 8229  1-312 HUVDB53 1618 509119 AC012265 8230  1-340 HUVDD09 1620 707061 AC020661 8231  1-143 2042-2218 2970-3063 3209-3270 3343-5080 6183-6473 6577-8040 HUVDD09 1620 707061 AC022835 8232  1-191 HUVDD09 1620 707061 AC025166 8233   1-1464 HUVDD09 1620 707061 AC022835 8234  1-310 HUVDD09 1620 707061 AC025166 8235  1-291 HUVDD09 1620 707061 AC020661 8236  1-270 HUVDD09 1620 707061 AC025166 8237  1-270 HUVDF84 1622 526248 AC005319 8238  1-500 HUVDF84 1622 526248 AC005319 8239  1-195 HUVDI28 1624 530558 AC019221 8240   1-1047 1216-1744 1897-2018 2020-2411 3079-3142 4571-5609 5750-5845 7019-7362 9012-9414 10076-10170 12381-12686 13742-15856 HUVDI28 1624 530558 AC019072 8241   1-1043 HUVDI28 1624 530558 AC019221 8242  1-309 HUVDI28 1624 530558 AC019072 8243  1-526 681-801 HUVDL30 1626 530387 AC012307 8244  1-412  472-1744 HUVDL30 1626 530387 AC012307 8245  1-735 HUVDO25 1627 679477 AC023247 8246  1-639 1201-1344 HUVDO25 1627 679477 AC004134 8247  1-639 1201-1344 HUVDO25 1627 679A77 AC023247 8248  1-443 HUVDO25 1627 679A77 AC004134 8249  1-443 HUVDP95 1628 530386 AC016901 8250  1-102 525-581 2057-2142 4836-4922 7896-8518 8902-9266 9524-9956 10085-10276 10366-10523 11312-11968 HUVDP95 1628 530386 AC020566 8251  1-622 1005-1369 1627-2060 2189-2377 2470-2626 3415-4071 HUVDP95 1628 530386 AC016594 8252  1-102 525-581 2057-2142 4836-4922 7897-8519 8903-9267 9525-9957 10086-10277 10367-10524 11313-11969 12174-12740 13281-14490 15022-15220 17186-17508 17563-17615 17759-18259 18289-20530 HUVDP95 1628 530386 AC016901 8253  1-561 HUVDP95 1628 530386 AC020566 8254  1-671 HUVDP95 1628 530386 AC016901 8255  1-204 HUVDP95 1628 530386 AC020566 8256  1-183 HUVDP95 1628 530386 AC016594 8257  1-204 HUVDP95 1628 530386 AC016594 8258   1-1093 1494-2538 HUVDS26 1629 958027 AC004111 8259  1-575 HUVDS26 1629 958027 AC004111 8260  1-327 HUVDS26 1629 958027 AC004111 8261  1-814 HUVDU51 1630 868660 AC025220 8262  1-289 HUVDU51 1630 868660 AC025225 8263  1-289 HUVDU51 1630 868660 AL009183 8264  1-638 1698-1986 2294-2509 2514-2585 3279-3605 4335-5324 5604-5876 HUVDU51 1630 868660 AC025225 8265  1-216 221-292 HUVDU51 1630 868660 AC025220 8266  1-638 HUVDU51 1630 868660 AC025225 8267  1-637 HUVDU51 1630 868660 AL009183 8268  1-116 HUVDU51 1630 868660 AL009183 8269  1-122 HUVED54 1632 534783 AL035405 8270  1-372 HUVED54 1632 534783 AL035405 8271  1-261 HUVED54 1632 534783 AL035405 8272  1-102 HUVED65 1633 527937 AC036127 8273  1-458 HUVED65 1633 527937 AC036127 8274  1-149 HUVED65 1633 527937 AC036127 8275  1-416 HUVFA55 1635 868779 AC007378 8276  1-529 HUVFA55 1635 868779 AC007378 8277  1-208 HUVFB48 1636 967815 AL390961 8278  1-321 HUVFB48 1636 967815 AC022245 8279  1-342 HUVFB48 1636 967815 AL390961 8280  1-142 HUVFB69 1637 868782 AC022575 8281  1-620 HUVFB69 1637 868782 AC016032 8282  1-620 HUVFB69 1637 868782 AC073344 8283  1-620 HUVFB69 1637 868782 AC016032 8284  1-346 HUVFB69 1637 868782 AC073344 8285  1-346 HUVFC07 1638 952080 AC015900 8286   1-1535 HUVFH03 1639 922064 AC069496 8287  1-397 HUVFH03 1639 922064 AC069496 8288  1-525 HUVFH32 1640 934003 AC011077 8289  1-339 HUVFH32 1640 934003 AP001016 8290  1-339 HUVFH32 1640 934003 AP002381 8291  1-339 HUVFH32 1640 934003 AP001016 8292  1-248 HUVFH32 1640 934003 AC011077 8293  1-248 HUVFH32 1640 934003 AP002381 8294  1-248 HUVFI03 1641 868776 AC024712 8295  1-171 HUVFK11 1642 965765 AC055840 8296  1-95 HUVFK11 1642 965765 AL353807 8297  1-478 HUVFK11 1642 965765 AL353807 8298  1-459 HUVFK11 1642 965765 AL353807 8299  1-740 HUVFK58 1643 868784 AC024578 8300  1-787 HUVFK58 1643 868784 AC024578 8301  1-365 HUVFK58 1643 868784 AC024578 8302  1-455 HUVFL71 1644 958059 AL354673 8303  1-529 HUVFL71 1644 958059 AC024013 8304  1-529 HUVFT28 1647 870617 AC012600 8305  1-507 2756-3737 3755-4805 HUVFT28 1647 870617 AC012515 8306  1-604 2978-3484 5369-5489 5732-6714 6732-8593 9071-9596 10007-10688 11077-11936 11999-12352 12393-12826 12889-13172 14459-14905 15045-15332 15471-15604 16006-16132 16983-17141 18515-20238 20365-20760 21907-22420 22584-23772 24017-24060 24693-24857 25545-25576 HUVFT28 1647 870617 AC008116 8307  1-604 1378-2594 2980-3486 5371-5491 5735-6716 6734-8595 9073-9598 10009-10690 11079-11938 12001-12354 12395-12828 12891-13175 14461-14907 15047-15334 15473-15606 16008-16134 16985-17143 18110-20236 20363-20758 21905-22418 22582-23770 24691-24846 25543-25574 HUVFT28 1647 870617 AC012600 8308   1-1221 HUVFT28 1647 870617 AC012515 8309  1-107 HUVFT28 1647 870617 AC012515 8310  1-163 HUVFT28 1647 870617 AC008116 8311  1-163 HUVFT28 1647 870617 AC008116 8312  1-104 HUVGZ77 1650 909169 AC040977 8313  1-32 411-784 1015-1238 HUVGZ77 1650 909169 AC015918 8314  1-32 411-784 1015-1238 1331-1701 2014-2138 HUVHB35 1651 868751 AC005683 8315  1-196 302-372  839-1057 1691-1918 2676-2791 3763-4031 5738-6460 7068-7266 8789-9240 10436-10852 13855-14025 17307-17855 18105-18217 22503-23073 23416-24726 25238-25727 27347-27779 34463-34627 34784-36975 HUVHB35 1651 868751 AF172277 8316  1-196 302-372  896-1074 1699-1926 2684-2799 3774-4042 5750-6472 7044-7312 8835-9286 10482-10898 13901-14071 17353-17901 18151-18263 22833-23407 23750-25060 25572-26061 27681-28113 34798-34962 35119-37310 HUVHB35 1651 868751 AC005683 8317  1-527 HUVHB35 1651 868751 AF172277 8318  1-527 HUVHB59 1652 963129 AC011448 8319  1-406 7558-7707 8256-8999  9619-10069 10534-11483 12567-13076 13206-13306 14715-15081 15383-16006 17113-17421 20025-20379 20494-21037 21820-22049 25986-26138 26738-27046 30607-30829 31608-32051 32666-33121 33412-33853 33981-34267 34795-34926 36372-36867 37528-38224 38263-38433 39877-40078 40299-40555 40657-40936 43330-43632 44090-44737 46930-47485 47555-51146 53945-54090 54624-55209 55358-55711 55751-57192 57277-57864 57977-58467 58604-58920 59772-59859 59916-60034 61018-61515 61960-62306 63123-63432 63712-63837 63999-64308 66414-66594 67713-67793 68533-69307 69537-69730 HUVHB59 1652 963129 AC011448 8320  1-544 HUVHB59 1652 963129 AC011448 8321  1-293 HUVHG80 1655 968507 AC002076 8322  1-415 HUVHG80 1655 968507 AC002076 8323   1-1551 HUVHG80 1655 968507 AC002076 8324  1-118 HUVHI07 1656 952090 AC073334 8325   1-1383 HUVHI07 1656 952090 AC073334 8326  1-192 HUVHU74 1658 868649 AL355855 8327  1-478 HUVHU74 1658 868649 AC025405 8328  1-478 HUVHU74 1658 868649 AL355855 8329   1-1183 HUVHU74 1658 868649 AC025405 8330   1-1182 HUVHU74 1658 868649 AL355855 8331  1-443 HUVHU74 1658 868649 AC025405 8332  1-442 HVCBV04 1660 925844 AL358172 8333  1-717 HVCBV04 1660 925844 AL136370 8334  1-717 HVCBV04 1660 925844 AL358172 8335  1-356 HVCBV04 1660 925844 AL358172 8336  1-647 HVCBV04 1660 925844 AL136370 8337  1-356 HVCBV04 1660 925844 AL136370 8338  1-647 HVCCK04 1662 925796 AC009861 8339   1-1379 HVCCK04 1662 925796 AC016949 8340   1-1381 HVCCK04 1662 925796 AC009861 8341  1-743 HVCCK04 1662 925796 AC009861 8342  1-855 HVCCK04 1662 925796 AC016949 8343  1-855 HVCCK04 1662 925796 AC016949 8344  1-86 589-770 1468-2212 2994-5375 5393-7226 7602-9856 10092-10593 11034-11679 13908-14759 HVVBK45 1667 964102 AL162853 8345   1-3940 HVVBK45 1667 964102 AC068175 8346   1-1900 HVVBK45 1667 964102 Z98172 8347  1-100 3320-6223 6258-7123 HVVBK45 1667 964102 AL162853 8348  1-476 HVVBK45 1667 964102 AL162853 8349   1-1290 1418-2787 HVVBK45 1667 964102 AC068175 8350  1-865 HVVBK72 1668 933167 AC008947 8351  1-125 1365-2751 HVVBK72 1668 933167 AC016612 8352  1-633 3297-3421 4587-5973 HVVBK72 1668 933167 AC008860 8353  1-633 3297-3421 4588-5974 HVVBK72 1668 933176 AC008947 8354  1-489 HVVBK72 1668 933176 AC016612 8355  1-408 HVVBK72 1668 933176 AC016612 8356  1-500 HVVBK72 1668 933176 AC008860 8357  1-408 HVVBK72 1668 933176 AC008860 8358  1-500 HVVBV44 1669 917559 AC008719 8359  1-242 HVVCO01 1670 913996 AC053484 8360  1-889 HVVCO01 1670 913996 AC023961 8361  1-889 HVVBM06 1674 933528 AF188031 8362  1-186 744-865 3969-4014 4551-4771 5464-5965 HVVBM06 1674 933528 AF188031 8363  1-481 HVVBM06 1674 933528 AF188031 8364  1-292 HUVHL82 1675 912011 AC004596 8365  1-70 786-966 1113-1199 1510-1580 1841-1904 2162-2231 2325-2486 2586-6603 6650-8125 8240-8441 8573-10040 HUVHL82 1675 912011 AC004596 8366  1-386 HUVHL82 1675 912011 AC004596 8367  1-519 1032-1253 3288-3977 4296-5037 5065-6012 6068-6617 7947-8275 8567-10680 HUVHI06 1676 952479 AP000876 8368   1-1990 2006-5890 HUVHI06 1676 952479 AC006238 8369   1-2271 2287-6172 7457-7798 8669-9191 9453-9805 HUVHI06 1676 952479 AC006238 8370  1-439 HUVGP05 1677 930892 AC009871 8371  1-448 HUVGP05 1677 930892 AC009812 8372  1-555 HUVGP05 1677 930892 AC009871 8373   1-1510 HUVGP05 1677 930892 AC009812 8374   1-1510 HUVFE03 1680 922889 AL357621 8375  1-226 244-695 HUVFE03 1680 922889 AL357621 8376  1-250 HUVDH61 1685 526590 AC006129 8377  1-438 HUVCU26 1686 974232 AC005342 8378  1-695 HUVCU26 1686 974232 AC005342 8379  1-416 HUVCU26 1686 974232 AC005342 8380  1-275 HUVBC21 1688 671479 AL136170 8381   1-2421 2585-3666 3742-3807 3903-4614 4708-4785 HUVBC21 1688 671479 AL136170 8382  1-77 1950-2416 2558-2959 3957-4319 HUVAA46 1689 667943 AL035400 8383  1-602 1503-1697 3827-4399 4614-5805 HUNAK12 1690 839574 AC027778 8384  1-454 HUNAK12 1690 839574 AC006327 8385  1-454 HUNAK12 1690 839574 AC027778 8386  1-173 HUNAK12 1690 839574 AC006327 8387  1-285 HUNAG41 1691 711543 AC015480 8388  1-564 HUNAG41 1691 711543 AC023138 8389  1-564 HUNAF22 1692 800452 AC006222 8390  1-442 HUNAD10 1697 968590 AC073349 8391   1-1351 HUNAD10 1697 968590 AC073349 8392  1-147 HUNAD10 1697 968590 AC073349 8393  1-746 HUNAC68 1698 753817 AL353727 8394  1-580 4850-5325 5800-6282 6475-6544 6648-6977 8563-11289 12142-12783 12858-13147 13154-13434 13613-13740 15488-15743 15955-15992 16231-16359 16374-16745 16974-17032 17437-17545 17841-17880 18596-18751 19250-19371 HUNAC68 1698 753817 AL358790 8395  1-36 118-200  268-2563 HUNAC68 1698 753817 AC009144 8396  1-380 1161-1306 2510-3089 7359-7834 8309-8791 8984-9053 9157-9486 11072-13798 14651-15292 15367-15656 15663-15943 16122-16249 17998-18253 18465-18502 18741-18869 18884-19255 19484-19542 20242-20390 21106-21261 21755-21893 23252-23319 25611-25701 26408-26563 26828-27037 27045-27154 HUNAC68 1698 753817 AL358790 8397  1-376 HUNAC68 1698 753817 AL358790 8398  1-103 HUNAB76 1699 968754 AC019250 8399  1-726 HUNAB76 1699 968754 AC024119 8400  1-726 HUNAB76 1699 968754 AL049715 8401  1-299 HUNAB76 1699 968754 AC019250 8402  1-129 HUNAB76 1699 968754 AC019250 8403  1-453 HUNAB76 1699 968754 AC024119 8404  1-469 HUNAB76 1699 968754 AC024119 8405  1-582 HUNAB76 1699 968754 AL049715 8406  1-469 HUNAB76 1699 968754 AL049715 8407  1-539 HUNAB42 1700 714264 AL121585 8408  1-775 HUNAB42 1700 714264 AL121585 8409  1-79 1720-2905 HUKFS69 1701 754186 AL356852 8410  1-592 HUKFS69 1701 754186 AC068046 8411  1-766  860-1860 1960-2625 HUKFS69 1701 754186 AL021068 8412  1-766  860-1860 1960-2625 HUKFS69 1701 754186 AC068046 8413  1-467 HUKFS69 1701 754186 AL356852 8414  1-602 HUKFS69 1701 754186 AC068046 8415  1-602 HUKFS69 1701 754186 AL021068 8416  1-467 HUKFL89 1702 574525 AC053531 8417  1-643 HUXFL89 1702 574525 AC025788 8418  1-643 HUKFL89 1702 574525 AC026250 8419  1-516 HUKFL89 1702 574525 AC026250 8420  1-388 HUKFL71 1703 760581 AC073057 8421  1-241 HUKFL71 1703 760581 AC073057 8422  1-105 HUKFL52 1704 574523 AC002302 8423  1-851 HUKFE56 1706 574381 AC067901 8424  1-570 HUKFE56 1706 574381 AP002822 8425  1-576 HUKFE56 1706 574381 AC067901 8426   1-3799 HUKFE56 1706 574381 AP002822 8427   1-3799 HUKFD95 1707 796014 AC044881 8428  1-610  661-1115 HUKFD95 1707 796014 AC026292 8429  1-454 HUKFD95 1707 796014 AC026291 8430  1-610  661-1114 HUKFD95 1707 796014 AC044881 8431  1-689 HUKFD95 1707 796014 AC026291 8432  1-689 HUKFD95 1707 796014 AC026291 8433  1-249 HUKEY01 1708 921504 AC023479 8434  1-878 HUKEY01 1708 921504 AL353151 8435   1-1947 HUKEY01 1708 921504 AC011871 8436  1-464 HUKEY01 1708 921504 AL136231 8437   1-1947 4426-5048 6590-6760 7264-7384 7980-8163 HUKEY01 1708 921504 AC023479 8438  1-297 HUKEY01 1708 921504 AL353151 8439  1-966 HUKEY01 1708 921504 AC011871 8440  1-508 HUKEY01 1708 921504 AL136231 8441  1-304 HUKER62 1709 772501 AC069076 8442  1-116 486-680 1904-2035 2615-2745 2944-3073 3778-4744 5131-5234 5328-6647 HUKER62 1709 772501 AC004754 8443  1-108 415-503 559-667 1308-1458 2640-2791 2981-3442 3936-4211 4832-5135 7065-7155 7723-7848 8596-9232  9936-10061 10421-10615 11839-11970 12549-12679 12878-13007 13714-14680 15067-15170 15264-16579 HUKER62 1709 772501 AC069076 8444  1-637 HUKER62 1709 772501 AC004754 8445  1-357 HUKDY02 1711 920815 AC069195 8446  1-488 HUKDY02 1711 920815 AC012306 8447   1-1805 HUKDY02 1711 920815 AC012306 8448  1-490 HUKCP30 1714 690933 AC011477 8449  1-580 HUKCP30 1714 690933 AC011477 8450  1-584 HUKCO11 1715 967742 AC022972 8451  1-96 511-867 3365-3592 5373-5521 6677-6961 7423-7816 7924-8345 HUKCO11 1715 967742 AC022972 8452  1-736 HUKCC25 1717 529723 AC007378 8453  1-259 HUKAT59 1719 628540 AL365274 8454   1-1254 HUKAM19 1722 672076 AC022022 8455  1-318 HUKAM19 1722 672076 AC022022 8456  1-297 HUKAL44 1724 716927 AC073462 8457  1-46 2717-4929 4991-5459 5581-5827 6813-7648 8152-8598 8796-9240 10094-10567 10604-11064 11694-11815 12072-12344 12700-12807 HUKAL44 1724 716927 AC073462 8458  1-152 HUKAJ91 1725 790487 AC024670 8459   1-1661 HUKAJ91 1725 790487 AC020746 8460   1-1661 HUKAJ91 1725 790487 AC024670 8461   1-1032 HUKAJ91 1725 790487 AC020746 8462   1-1032 HUKAB63 1728 625273 AC068451 8463  1-800  870-1610 HUKAB63 1728 625273 AC068451 8464  1-133 HUKAB25 1729 677470 AC025802 8465  1-531 HUKAB25 1729 677470 AC025624 8466  1-531 HUKAB25 1729 677470 AC025802 8467   1-2446 HUKAB25 1729 677470 AC025624 8468  1-125 HUKAB25 1729 677470 AC025802 8469  1-120 HUKAB25 1729 677470 AC025624 8470   1-2446 HUKAA54 1730 503630 AL022325 8471  1-154 1810-1865 1947-2233 2391-2757 2828-4196 4215-4421 4990-5074 5133-5294 5676-6489 6529-7035 HUKAA54 1730 503630 AL031588 8472  1-154 1810-1865 1947-2233 2391-2757 2828-4196 4215-4421 4990-5074 5133-5294 5676-6489 6529-7035 HUKAA54 1730 503630 AL022325 8473  1-875 HUKAA54 1730 503630 AL031588 8474  1-875 HUDBE95 1734 795796 AC019073 8475  1-780 5430-5615 7641-7685 10826-10887 11255-11332 12359-12669 13590-13776 16097-16197 16225-16569 17409-17588 17614-18145 18212-18277 20025-20135 21203-21289 21668-21798 22067-22836 22902-23233 23289-24983 HUDBE95 1734 795796 AC009079 8476  1-780 1966-2659 5432-5617 7643-7687 10830-10891 11259-11336 12363-12673 13594-13780 16101-16201 16229-16573 17510-17593 17618-18149 18216-18281 20020-20130 21198-21284 21663-21793 22060-22829 22895-23226 23282-24977 HUDBE95 1734 795796 AC019073 8477  1-464 HUDBE95 1734 795796 AC009079 8478  1-454 HUDAK19 1740 671974 AC024249 8479  1-882 1119-1964 HTTKC85 1742 956206 AC007246 8480  1-445 HTTKC85 1742 956206 AC007246 8481  1-653 HTTKC85 1742 956206 AC007246 8482  1-766 HTTJN26 1744 869612 AC010761 8483  1-545  730-2324 2733-2817 2910-2993 3334-3705 4186-4362 HTTJN26 1744 869612 AC010761 8484  1-158 HTTJN26 1744 869612 AC010761 8485  1-244 HTTIX05 1746 931024 AL138955 8486  1-492  646-1277 1480-2938 HTTIX05 1746 931024 AL136104 8487  1-493  647-1278 1481-2939 HTTIX05 1746 931024 AL136104 8488  1-124 HTTIN11 1749 965920 AC073580 8489  1-815 HTTIN11 1749 965920 AL109916 8490  1-815 HTTIN11 1749 965920 AC073580 8491  1-436 HTTIN11 1749 965920 AC073580 8492  1-228 HTTIN11 1749 965920 AL109916 8493  1-436 HTTIN11 1749 965920 AL109916 8494  1-228 HTTIE08 1750 958169 AC026405 8495   1-4307 HTTIE08 1750 958169 AC020566 8496  1-575 HTTIE08 1750 958169 AC016901 8497   1-6684 HTTIE08 1750 958169 AC020566 8498  1-34 1050-1364 HTTIE08 1750 958169 AC016901 8499  1-131 1868-2214 2273-2385 3084-3172 HTTIB12 1751 969568 AC026576 8500  1-715 HTTHJ56 1752 944914 AC013715 8501  1-241 407-704 1629-1750 3363-3439 6942-7140 7436-7629 11318-11960 HTTFG12 1753 751809 AC068289 8502   1-1168 HTTFG12 1753 751809 AC068289 8503  1-104 HTTEQ59 1755 739445 AC018654 8504  1-113  608-2226 2955-3217 3366-4135 4148-4842 HTTEQ59 1755 739445 AC022073 8505  1-113 608-2226 2955-3217 3366-4135 4148-4842 HTTEQ01 1756 917156 Z83845 8506  1-684 HTTEQ01 1756 917156 Z83845 8507  1-504 658-707 1786-3045 3351-4099 HTTEO59 1757 900662 AC046168 8508   1-2879 HTTEO53 1758 728344 AC074116 8509  1-280  905-4002 HTTEO53 1758 728344 AL162722 8510  1-280  905-3688 HTTEO53 1758 728344 AC074116 8511  1-99 HTTEO53 1758 728344 AL162722 8512  1-99 HTTEJ56 1759 573669 AC068707 8513  1-134 1054-1276 1688-1740 2572-2856 2936-3012 3748-3941 4846-4969 5395-5467 5675-6158 HTTEJ56 1759 573669 AC068707 8514   1-1098 HTTEB05 1760 932294 AL031672 8515   1-1512 HTTEB05 1760 932294 AL031672 8516  1-489 HTTEB05 1760 932294 AL031672 8517  1-692 4641-5166 6143-6251 8784-8849 11398-11796 11851-12038 13499-13858 14606-14716 17177-17863 19079-19195 19315-19699 20154-20572 22216-22455 22597-23544 HTTDO59 1761 744438 AL160282 8518  1-671  781-2678 2858-2994 3178-3347 3426-3693 HTTDM42 1762 460948 AC073619 8519  1-421 704-793 1909-2043 HTTDM42 1762 460948 AL354745 8520  1-421 704-793 1910-2044 2204-2966 3204-4359 HTTDM42 1762 460948 AL354745 8521  1-904 HTTDM42 1762 460948 AL354745 8522  1-233 BTTDL81 1763 694222 AL022328 8523  1-481 729-828 1094-1193 1289-1396 1553-1617 1798-1929 2089-2152 2247-4100 4146-4381 4518-4577 4865-4961 5157-5580 5725-6072 HTTDL81 1763 694222 AL022328 8524  1-723 HTTDL81 1763 694222 AL022328 8525  1-81 162-241 315-880 1024-1324 1365-1937 2215-2794 HTTDL75 1764 766551 AC068013 8526  1-384 HTTDL75 1764 766551 AC068471 8527  1-697 HTTDL75 1764 766551 AC074378 8528  1-697 HTTDL75 1764 766551 AC074378 8529  1-495 HTTCQ95 1766 796674 AC026065 8530  1-100 772-894 1216-1581 1841-2015 2108-2519 3025-3350 3659-4132 6075-6743 HTTBR42 1770 714220 AL157409 8531  1-570 4245-4986 HTTBR42 1770 714220 AL157409 8532  1-312 HTTBO82 1772 780164 AC044902 8533  1-436 477-893 HTTBO82 1772 780164 AC009595 8534  1-436 477-893 HTTBO82 1772 780164 AC044902 8535  1-256 HTTBM03 1773 925409 AC031984 8536  1-766 2180-2586 3286-3634 3651-3858 3895-4311 HTTBM03 1773 925409 AL050318 8537  1-766 2178-2584 3284-3632 3649-3856 3893-4309 4861-5005 7178-7361 11400-11880 12124-12392 13017-13267 15332-15583 15793-16031 16947-17288 18668-18837 19381-19764 21255-21574 22689-22887 23670-23952 27931-28039 28646-28948 29548-29705 30258-32335 HTTBM03 1773 925409 AL390374 8538  1-766 2178-2584 3284-3632 3649-3856 3893-4309 4861-5005 7178-7362 11063-11173 11400-11880 12124-12392 13017-13268 15332-15583 15795-16033 16952-17289 18674-18843 19387-19770 21261-21580 22695-22893 23676-23958 27937-28045 28652-28954 29556-29713 30266-32343 HTTBM03 1773 925409 AC031984 8539  1-145 HTTBM03 1773 925409 AL050318 8540  1-151 HTTBM03 1773 925409 AL050318 8541  1-195 HTTBM03 1773 925409 AL390374 8542  1-195 HTTBI80 1774 781590 AC008628 8543  1-162 1001-1703 HTTBI80 1774 781590 AC010226 8544  1-162 1001-1703 HTTBH95 1775 530559 AL121759 8545  1-182 1815-1886 HTTBH95 1775 530559 AL121759 8546  1-457 HTTAQ60 1778 742377 AC055720 8547  1-643  842-1218 HTTAQ60 1778 742377 AC024145 8548  1-643  842-1223 HTTAQ60 1778 742377 AC055720 8549  1-679 HTTAQ60 1778 742377 AC024145 8550  1-679 HTTAQ60 1778 742377 AC024145 8551  1-135 HTTAP21 1780 671488 AL023803 8552  1-198 4122-4247 8722-8781 12640-12742 15684-15778 17532-17609 17745-18841 19072-19205 20937-21397 21427-21993 22264-22342 24544-24618 28047-28160 30396-30560 32340-33565 HTTAP21 1780 671488 AL023803 8553  1-293 HTTAP21 1780 671488 AL023803 8554  1-414 HTTAP09 1781 826343 AC023593 8555  1-437 HTTAP09 1781 826343 AC012406 8556  1-437 HTTAP09 1781 826343 AC012406 8557  1-786 1865-1938 HTTAP09 1781 826343 AC023593 8558  1-787 1865-1938 HTTAC77 1785 772735 AC021291 8559  1-779 NTTAA94 1786 793001 AL031255 8560  1-908 HTTAA94 1786 793001 AL031255 8561  1-480 HTTAA39 1787 710355 AC016691 8562  1-526  564-1577 HTTAA39 1787 710355 AC015719 8563   1-1149 HTTAA39 1787 710355 AC016691 8564  1-496 HTTAA39 1787 710355 AC016691 8565  1-106 HTTAA39 1787 710355 AC015719 8566  1-840 HTLIP06 1788 934207 AL162586 8567   1-2160 2297-2470 HTLIP06 1788 934207 AL162426 8568   1-2160 2297-2472 3211-3477 3629-4087 HTLIP06 1788 934207 AC007430 8569   1-2160 2297-2472 3211-3477 3629-4087 HTLIP06 1788 934207 AL162586 8570  1-136 294-491 2350-2692 3660-3898 HTLIP06 1788 934207 AL162426 8571  1-136 294-491 2351-2693 3661-3899 HTLIP06 1788 934207 AC007430 8572  1-136 294-491 2351-2693 3661-3899 HTLIP06 1788 934207 AL162426 8573  1-118 HTLIP06 1788 934207 AC007430 8574  1-118 HTLHS69 1793 870152 AC009095 8575  1-220 227-466  573-1448 HTLHS05 1794 933720 AL121753 8576  1-77  91-640 2531-2639 3380-3625 3692-4433 4677-4862 5043-5355 5532-5893  6299-10579 12966-13230 14676-15242 15749-15996 16066-16393 16675-17238 17381-17885 18029-18260 19347-19477 20064-20199 20849-21010 HTLHS05 1794 933720 AL356652 8577  1-77  91-640 2531-2639 3380-3625 3692-4433 4677-4862 5043-5355 5532-5893  6299-10590 12979-13243 14689-15255 15762-16052 16079-16406 16688-17251 17394-17898 18042-18273 19363-19509 20088-20188 20863-21024 HTLHS05 1794 933720 AL121753 8578  1-437 HTLHS05 1794 933720 AL121753 8579  1-638 793-854 HTLHS05 1794 933720 AL356652 8580  1-437 HTLHS05 1794 933720 AL356652 8581  1-638 793-854 HTLHJ51 1796 865399 AC027421 8582  1-146 1403-3399 HTLHJ51 1796 865399 AC025860 8583  1-146 1402-3398 HTLHJ51 1796 865399 AL353622 8584  1-146 1402-3398 HTLHB93 1797 945862 AL161656 8585  1-585 HTLHB93 1797 945862 AL035460 8586  1-585 HTLHB93 1797 945862 AL161656 8587  1-29  92-459 544-844 HTLHB93 1797 945862 AL161656 8588  1-754 HTLHB93 1797 945862 AL035460 8589  1-29  92-459 544-844 HTLHB93 1797 945862 AL035460 8590  1-754 HTLGS10 1799 963458 AC055863 8591  1-34 227-316  895-1294 1518-1678 1917-2553 HTLGR32 1800 928245 AC013403 8592   1-1399 HTLGR32 1800 928245 AC013403 8593  1-391 HTLGR32 1800 928245 AC013403 8594  1-126 HTLGP84 1801 782194 AC020934 8595  1-58 591-853  900-1357 HTLGC43 1803 870228 AL118524 8596  1-903  936-2052 HTLGC43 1803 870228 AL118524 8597  1-497 HTLEQ92 1804 932882 AC009109 8598  1-303 1003-1241 2173-2763 HTLEQ92 1804 932882 AC010531 8599  1-303 1003-1241 2173-2763 2907-3967 4804-4849 4950-7755 HTLEQ92 1804 932882 AC009109 8600  1-722 HTLEQ92 1804 932882 AC010531 8601   1-1592 HTLEP21 1805 671151 AC016774 8602  1-138 467-569 810-930 1056-1149 1553-1686 1774-2544 HTLEP21 1805 671151 AC010789 8603  1-138 468-570 811-931 1057-1150 1554-1687 1775-2546 HTLEP21 1805 671151 AC016774 8604  1-594 1023-1155 1772-2162 2448-2739 2975-3438 3681-4096 4814-4865 5289-5389 5443-5627 7000-7166 7396-8248 8876-9167 10516-10689 11193-11857 12200-12372 12455-12745 13874-14148 14398-14684 15738-15861 16053-16243 17510-17938 18019-18179 18259-18528 18587-18676 18960-19577 19606-20010 20036-21667 22067-26217 26261-26631 26869-27524 27631-28143 28212-28560 29119-29156 29687-30245 30256-31203 31798-33971 HTLEP21 1805 671151 AC010789 8605  1-595 1024-1156 1773-2165 2447-2738 2974-3437 3680-4095 4813-4864 5288-5388 5442-5626 6999-7165 7395-8247 8875-9166 10515-10688 11192-11856 12199-12371 12454-12755 13981-14147 14397-14683 15737-15860 16052-16242 17509-17937 18018-18178 18258-18527 18586-18675 18959-19576 19605-20009 20035-21666 22243-26224 26240-26630 26868-27523 27630-28149 28212-28560 29119-29156 29688-30247 30269-31205 31800-33973 HTLDO01 1812 913669 AC002056 8606  1-1300 HTLDO01 1812 913669 AC000036 8607  1-1300 2362-2937 HTLDO01 1812 913669 AC002056 8608  1-375 HTLDO01 1812 913669 AC000036 8609  1-829 1755-2331 3054-3393 5260-5322 HTLDO01 1812 913669 AC000036 8610  1-375 HTLCZ79 1815 572853 AC004064 8611  1-285 HTLCZ79 1815 572853 AL161939 8612  1-285 HTLCZ79 1815 572853 AL118502 8613  1-285 HTLCZ79 1815 572853 AC004064 8614  1-97 HTLCZ79 1815 572853 AC004064 8615  1-471  571-1561 HTLCZ79 1815 572853 AL161939 8616  1-471  571-1561 HTLCZ79 1815 572853 AL118502 8617  1-471  571-1561 HTLCO02 1817 921045 AC066588 8618  1-242 2043-2258 HTLCG65 1818 413333 AC015549 8619  1-167 HTLCG65 1818 413333 AC006060 8620  1-171 3245-3475 3590-3742 4110-4269 5242-5535 6465-6516 HTLCG59 1819 530039 AC027712 8621  1-46 3805-3943 5188-5370 6708-6843 7531-7689 8008-8127 8669-8788 9234-9406  9698-10187 10689-15514 HTLCG59 1819 530039 AL356097 8622  1-46 3805-3943 5188-5370 6709-6844 7530-7688 8007-8126 8668-8787 9234-9406  9698-10187 10693-15517 HTLCG59 1819 530039 AC027113 8623  1-46 3805-3944 5189-5371 6709-6844 7530-7688 8007-8126 8668-8787 9233-9405  9697-10186 10692-15518 HTLCG59 1819 530039 AC027712 8624  1-595 HTLCG59 1819 530039 AL356097 8625  1-595 HTLCG59 1819 530039 AC027113 8626  1-595 HTLBH67 1821 751985 AC008439 8627  1-62 293-400 452-976 1016-1058 1463-1534 1886-2026 2110-2249 2401-2463 3324-4027 4192-4288 4694-5330 5485-5650 5813-6262 6273-6401 6475-6559 6728-6847 6979-7205 7573-7676 7730-8146 8334-8866 8885-9392 HTLBH67 1821 751985 AC008781 8628  1-85 254-371 505-731 1098-1201 1255-1671 1718-2387 2408-2915 3113-3244 3382-4278 4504-4538 4650-5645 HTLBH67 1821 751985 AC022420 8629  1-62 295-403 455-979 1019-1061 1466-1537 1890-2030 2114-2253 2405-2467 3328-4030 4195-4291 4697-5333 5488-5653 5816-6265 6276-6404 6478-6562 6731-6850 6982-7208 7575-7678 7732-8148 8195-8864 8885-9392 9590-9721  9859-10754 10980-11014 11126-12121 HTLBH67 1821 751985 AC005368 8630  1-64 294-399 451-975 1015-1057 1462-1533 1885-2025 2109-2248 2400-2462 3323-4026 4191-4287 4693-5329 5484-5649 5812-6264 6275-6403 6477-6561 6730-6849 6981-7207 7575-7678 7732-8148 8201-8868 8887-9394 9592-9723  9861-10759 10985-11019 11131-12126 HTLBH67 1821 751985 AC008781 8631  1-292 HTLBH67 1821 751985 AC022420 8632  1-323 1372-1431 1657-1821 2377-2485 4488-4700 4954-5061 6224-6547 6819-6965 7268-7333 8088-8593  9897-10068 10109-10623 10645-10680 10812-10871 10982-11123 11345-11383 11877-12000 12310-13467 HTLBH67 1821 751985 AC022420 8633  1-292 HTLBH67 1821 751985 AC005368 8634  1-292 HTLBC07 1822 954111 AC015841 8635  1-668 HTLBC07 1822 954111 AC018617 8636  1-672 HTLBC07 1822 954111 AC004586 8637  1-672 HTLBC07 1822 954111 AC015841 8638  1-124 HTLBC07 1822 954111 AC018617 8639  1-124 HTLBC07 1822 954111 AC004586 8640  1-514 681-994 1116-1732 1974-2431 2451-3123 3603-3698 4469-4606 5033-5496 6293-6890 6965-8015 8053-8130 HTLBC07 1822 954111 AC004586 8641  1-77 3689-3807 3960-4294 4692-4820 5674-5809 6237-6334 7138-7247 8211-8309 8720-8861  9797-10087 10098-10215 10448-11237 11311-11550 11566-11654 12306-12914 12929-13575 13587-13703 14256-14391 14535-14763 17193-17450 HTLAB29 1829 879168 AC026362 8642  1-689 508-653 1079-1226 1867-2043 2136-2239 2359-3327 3438-3958 4003-5312 HTLAB29 1829 879168 AC026362 8643  1-336 HTFBE02 1830 920507 AC022536 8644  1-31 340-421 1097-1262 2446-2621 3069-3161 3571-3791 4947-5076 5905-6987 HTFBE02 1830 920507 AC022536 8645  1-102 HTEQS95 1831 972746 AL133284 8646   1-1005 HTEQS95 1831 972746 AL133284 8647  1-258 HTEQS90 1832 973426 AP000635 8648  1-692 HTEQS90 1832 973426 AP000610 8649  1-691 HTEQS90 1832 973426 AP001547 8650  1-691 HTEQS90 1832 973426 AP000635 8651  1-543 HTEQS90 1832 973426 AP000610 8652  1-197 HTEQS90 1832 973426 AP001547 8653  1-197 HTBQS90 1832 973426 AP000610 8654  1-543 HTEQS90 1832 973426 AP001547 8655  1-543 HTEQP03 1833 870516 AC018931 8656  1-238 672-970 6605-6665 HTEQP03 1833 870516 AC018931 8657  1-323 373-560 HTEQB08 1835 958291 AL139106 8658  1-831 HTEQB08 1835 958291 AL162721 8659  1-831 HTEQB08 1835 958291 AL139106 8660  1-324 HTEQB08 1835 958291 AL162721 8661  1-261  805-1128 HTEOE28 1841 870581 AL139243 8662   1-1106 HTENY44 1842 870588 AC027544 8663  1-197 710-864 1263-1380 2382-2706 3184-3394 3970-4082 HTENY44 1842 870588 AC027544 8664  1-570 HTENY44 1842 870588 AC027544 8665  1-322 HTENV06 1843 933294 AL121753 8666  1-498 HTENV06 1843 933294 AL356652 8667  1-498 HTENV06 1843 933294 AL121753 8668  1-116 HTENV06 1843 933294 AL356652 8669  1-104 HTENL95 1848 795314 AC022930 8670  1-32  79-745  880-1680 1782-2276 2861-3730 4861-5265 HTENL95 1848 795314 AC069217 8671  1-32  79-745  880-1679 HTENL95 1848 795314 AF238376 8672  1-32  79-745  880-1680 HTENL95 1848 795314 AC022930 8673  1-150 215-626  662-1438 2351-2999 HTENL95 1848 795314 AC022930 8674  1-297 HTENL95 1848 795314 AC069217 8675  1-297 HTENL95 1848 795314 AF238376 8676  1-297 HTENL95 1848 795314 AC069217 8677  1-495 HTENL95 1848 795314 AF238376 8678  1-495 HTENA08 1850 958380 Z97985 8679  1-460  851-1242 1372-1475 2276-2373 HTENA08 1850 958380 Z97985 8680  1-264 HTEMY05 1851 880592 AC019326 8681  1-734 1378-6434 HTEMY05 1851 880592 AF129408 8682  1-734 1378-7065 HTEMY05 1851 880592 AC019326 8683  1-579 HIEMY05 1851 880592 AF129408 8684  1-756 HTEMU66 1853 944419 AL022167 8685   1-1796 HTEMU66 1853 944419 AC018903 8686  1-631 HTEMU66 1853 944419 AC068470 8687  1-706 HTEMU66 1853 944419 AL049186 8688  1-912 HTEMU66 1853 944419 AC022305 8689  1-686 HTEMU66 1853 944419 AL049186 8690  1-87 HTEMN80 1856 775543 AP001386 8691   1-2970 3001-4307 HTEMN80 1856 775543 AP002785 8692   1-2974 3005-4311 HTEMN80 1856 775543 AP001386 8693  1-300 HTEMN80 1856 775543 AP002785 8694  1-236 HTEMI51 1858 870613 AL365214 8695  1-94 3508-4007 HTELV29 1861 806421 AC068938 8696  1-643 HTELV29 1861 806421 AC073407 8697   1-2055 3690-3915 3928-4379 4421-5222 7704-8003 11303-11530 12021-12259 12917-14410 HTELV29 1861 806421 AC073407 8698  1-350 HTELP07 1862 952274 AC041014 8699  1-118 490-918 HTELP07 1862 952274 AC041014 8700  1-332 HTELA02 1864 918699 AC021688 8701  1-687 1014-1336 HTEKI62 1866 812862 AC005848 8702  1-164 343-428  578-2903 3020-3168 4072-4415 5074-5526 5547-5780 HTEKI62 1866 812862 AC005848 8703  1-863 1241-1590 1666-2167 2328-2424 2500-2950 3000-3341 3351-3962 3976-3995 4276-5430 5485-5585 5616-5892 6622-6727 7156-8018 HTEKD77 1868 772397 AC018865 8704   1-1638 HTEJV94 1869 793039 AC058807 8705  1-946 HTEJV94 1869 793039 AC003669 8706  1-946 HTEYN12 1871 653252 AL096763 8707  1-118 1052-1310 3744-4364 4488-4515 5291-5447 6507-7124 7157-7605 7842-8575 HTEJL30 1872 696784 AC012379 8708   1-2084 HTEJL30 1872 696784 AC009697 8709   1-2084 HTEJL30 1872 696784 AC012379 8710  1-142 HTEJL30 1872 696784 AC009697 8711  1-719 HTEJL30 1872 696784 AC012379 8712  1-719 HTEJL30 1872 696784 AC009697 8713  1-142 HTEJB07 1874 953801 AC073625 8714  1-494 2402-2532 HTEJB07 1874 953801 AC007394 8715  1-430 HTEJB07 1874 953801 AC073625 8716   1-1712 1727-2677 HTEJB07 1874 953801 AC007394 8717   1-1712 1727-2677 HTEIS34 1875 887112 AC069257 8718  1-635 725-895 1011-1169 1645-2361 2527-3215 3399-3766 3842-4045 HTEIS34 1875 887112 AC026308 8719  1-635 725-895 1011-1169 1645-2361 2527-3215 3399-3766 3842-4045 HTEIS34 1875 887112 AC069257 8720  1-165 HTEIS34 1875 887112 AC069257 8721  1-380 HTEIS34 1875 887112 AC026308 8722  1-381 HTEIS34 1875 887112 AC026308 8723  1-486 HTEIS25 1876 870660 AC053512 8724  1-252 304-440 462-606 851-994 HTEIS25 1876 870660 AL360086 8725  1-253 305-441 463-607 852-995 HTEHX57 1885 734976 AC023756 8726  1-91 1173-1400 3751-4383 4431-4890 5497-5769 5920-6396 HTEHX57 1885 734976 AP001152 8727  1-452 1059-1331 1482-1958 HTEHX57 1885 734976 AC011007 8728  1-79 3753-3901 9145-9297 9344-9538 13689-14081 14559-14683 15765-15992 17822-18243 18342-18974 19022-19481 20088-20360 20511-20987 HTEHX57 1885 734976 AC023756 8729   1-1701 1831-4730 HTEHX57 1885 734976 AP001152 8730   1-1702 1835-4742 HTEHX57 1885 734976 AC011007 8731   1-1701 HTEHV11 1886 967439 AL021331 8732  1-569 HTEHV11 1886 967439 AL021331 8733  1-690 HTEHS17 1887 664436 AC010255 8734  1-184 308-529 2761-3109 HTEHS17 1887 664436 AC010255 8735  1-502 HTEHS17 1887 664436 AC010255 8736  1-130  310-1003 1040-1331 HTEGU55 1890 931017 Z98752 8737   1-2035 HTEGU55 1890 931017 Z98752 8738  1-465 HTEGU55 1890 931017 Z98752 8739  1-415 HTEGC30 1896 690998 AC073079 8740  1-504 HTEFO46 1899 719280 AC068790 8741  1-31 136-656 HTEFO46 1899 719280 AC024438 8742  1-31 136-942 1083-4020 HTEFO28 1900 685383 AC023123 8743  1-119 151-982 1019-1286 1442-1755 1908-2137 2256-2608 2974-3413 4977-5488 5507-8584  8676-10198 HTEFO28 1900 685383 AC006534 8744  1-119 151-982 1019-1286 1442-1755 1986-2137 2256-2608 2974-3413 4977-5488 5507-8584  8676-10198 HTEFO28 1900 685383 AC023123 8745  1-546 601-659 HTEFO28 1900 685383 AC006534 8746  1-230 234-264 HTEFO28 1900 685383 AC023123 8747  1-237 239-272 HTEFO28 1900 685383 AC006534 8748  1-546 601-659 HTEET22 1906 675071 AC022930 8749  1-649 1562-2338 2374-2785 2850-2999 HTEET22 1906 675071 AC069217 8750  1-777  813-1224 1289-1366 HTEET22 1906 675071 AF238376 8751  1-38 1258-1452 3186-3304 3555-3746 6146-6232 8111-8262 9292-9751 10190-10839 11752-12528 12564-12975 13040-13189 HTEET22 1906 675071 AC022930 8752  1-460 HTEET22 1906 675071 AC022930 8753  1-405 1536-2405 2990-3484 3586-4386 4521-5187 5234-5265 HTEET22 1906 675071 AC069217 8754  1-402 HTEET22 1906 675071 AF238376 8755  1-408 HTEEF25 1907 677513 AC012330 8756  1-344 HTEEF25 1907 677513 AC008132 8757  1-344 HTEEF25 1907 677513 AC023491 8758  1-344 HTEEF25 1907 677513 AC008103 8759  1-583  683-2302 5090-5245 5708-5746 5973-6045 HTEEF25 1907 677513 AC023490 8760  1-582  682-2297 HTEEF25 1907 677513 AC008079 8761  1-583  683-2302 4878-5241 5704-5742 5969-6041 HTEEF25 1907 677513 AC007325 8762  1-583  683-2306 4881-5244 5707-5745 5972-6044 HTEEF25 1907 677513 AC007708 8763  1-582  682-2297 HTEEF25 1907 677513 AC007324 8764  1-582  682-2301 5089-5244 5707-5745 5972-6044 HTEEF25 1907 677513 AC008018 8765  1-582  682-2301 4877-5240 5703-5741 5968-6040 HTEEF25 1907 677513 AC007981 8766  1-340 HTEEF25 1907 677513 AC008103 8767  1-603 HTEEF25 1907 677513 AC008103 8768  1-233 HTEEF25 1907 677513 AC023490 8769  1-603 HTEEF25 1907 677513 AC008079 8770  1-452 1155-1470 1497-1744 6815-7114 8000-8325 8749-9359 10364-10577 10586-10884 11714-12079 14576-14752 16955-17117 17240-17567 21365-21630 23483-23784 23982-24078 24280-24312 25597-25744 25952-26024 26254-26692 27187-27493 27543-27657 27931-28344 31056-31145 31243-31541 31698-31846 33652-33750 34559-34729 34936-35276 36328-36748 36956-37092 37601-37650 38741-38979 40580-41206 HTEEF25 1907 677513 AC008079 8771  1-233 HTEEF25 1907 677513 AC007325 8772  1-603 HTEEF25 1907 677513 AC007325 8773  1-235 HTEEF25 1907 677513 AC007708 8774  1-603 HTEEF25 1907 677513 AC007324 8775  1-234 HTEEF25 1907 677513 AC007324 8776  1-603 HTEEF25 1907 677513 AC008018 8777  1-233 HTEEF25 1907 677513 AC008018 8778  1-603 HTEEF25 1907 677513 AC007981 8779  1-488 HTEEB82 1908 780161 AC026140 8780  1-81 1974-2064 2695-2852 2934-3354 4059-4360 4682-4800 HTEEB82 1908 780161 AL033531 8781  1-81 1974-2064 2695-2852 2934-3354 4059-4845 HTEEB82 1908 780161 AC026140 8782  1-212 HTEEB82 1908 780161 AL033531 8783  1-669 HTEEB82 1908 780161 AL033531 8784  1-212 HTEDX39 1909 530201 AC005726 8785  1-257 HTEDX39 1909 530201 AC005726 8786  1-124 HTEDX39 1909 530201 AC005726 8787  1-81 754-902 1011-1476 1836-2127 3328-3518 3715-3773 4307-4426 4516-4946 5049-5097 5496-5623 6425-6598 HTEDX04 1910 927850 AF111169 8788  1-136 1693-1823 1913-2092 2493-2707 4607-4680 HTEDX04 1910 927850 AF111169 8789  1-347 HTEDX03 1911 925353 AC005300 8790  1-202 HTEDX03 1911 925353 AC006946 8791  1-202 HTEDX03 1911 925353 AC006946 8792  1-168 HTEDW96 1912 881958 AC017028 8793  1-477  786-1004 HTEDW96 1912 881958 AC017028 8794  1-867 HTEDW59 1913 530448 AC025868 8795  1-217 HTEDW59 1913 530448 AC025868 8796  1-264 363-446 HTEDV86 1914 785818 AL356801 8797  1-763 HTEDV86 1914 785818 AL356801 8798  1-142 HTEDO75 1918 767024 AL049541 8799  1-910 HTEDJ92 1920 522827 AL390815 8800  1-295 HTEDI01 1923 961028 AC019205 8801  1-224 HTEDH30 1927 522936 AL049697 8802  1-57 1807-1921 2559-2625 HTEDH30 1927 522936 AL049697 8803  1-365  381-1034 HTEDH17 1928 522938 AC026124 8804  1-413 HTEDH17 1928 522938 AC012597 8805  1-413 HTEDH06 1929 869427 AC006251 8806  1-718  767-1512 1639-2023 2398-2655 2926-2990 3300-3357 4357-4395 5163-5275 5927-6337 6945-7074 7156-7444 HTEDH06 1929 869427 AC006251 8807  1-163 460-673 787-898 4433-4791 6955-7223 7246-7642 11004-11548 12185-12593 13374-13482 14491-14587 15381-16043 16395-16546 18407-18623 19528-19762 19852-20715 21495-21936 HTEDH06 1929 869427 AC006251 8808   1-400 HTEDF96 1932 614726 AC021163 8809  1-540  655-1021 1053-1143 1354-1536 1692-1762 1924-2030 2867-2962 3191-4078 4135-4228 4365-4458 4565-4675 4747-4815 4901-4977 5232-5675 6013-6910 HTEDF96 1932 614726 AC006942 8810  1-541  656-1023 1055-1145 1356-1538 1694-1764 1926-2032 3194-4081 4138-4231 4368-4461 4568-4678 4750-4818 4904-4980 5235-5678 6016-6914 7138-7281 7453-7737 7813-8322 8835-9123  9152-10108 10204-10288 10387-10448 11252-11414 11496-11676 11746-12218 12336-12436 13243-13426 13626-13767 13891-14067 14442-14596 15655-15742 16852-17292 17660-17764 18610-18921 19197-19405 19407-19499 20302-20404 20510-20780 21329-21458 HTEDF96 1932 614726 AC021163 8811  1-288 HTEDF96 1932 614726 AC006942 8812  1-288 HTEDF22 1935 908406 AL138891 8813  1-822 HTEDF22 1935 908406 AC002418 8814  1-823 HTEDF22 1935 908406 AC004386 8815  1-823 HTEDF22 1935 908406 AL138891 8816  1-155 HTEDF22 1935 908406 AC002418 8817  1-142 HTECE66 1936 522997 AL159160 8818  1-61 5520-5850 HTECE66 1936 522997 AL390071 8819  1-61 620-770 5508-5838 HTECE66 1936 522997 AL390071 8820  1-259 HTECE62 1937 523002 AC069401 8821  1-158 259-547 1614-2136 HTECE62 1937 523002 AC005232 8822  1-158 259-547 1614-2136 HTECE51 1939 870723 AC016976 8823  1-301 HTECE51 1939 870723 AC058805 8824  1-301 HTECE51 1939 870723 AC027764 8825  1-301 HTECE51 1939 870723 AC016976 8826  1-425 HTECE51 1939 870723 AC027764 8827  1-425 HTECE31 1941 508104 AC069360 8828  1-283 HTECE31 1941 508104 AC023850 8829  1-283 HTECE31 1941 508104 AC069360 8830  1-409 HTECE31 1941 508104 AC023850 8831  1-409 HTECD94 1943 527210 AC025959 8832  1-58  828-1050 2944-3114 3238-3330 HTECD94 1943 527210 AC025963 8833  1-127  951-1008 1778-2000 3894-4064 4188-4280 HTECD94 1943 527210 AC009451 8834  1-127  951-1008 1781-2003 3897-4067 4191-4283 HTECD94 1943 527210 AC025959 8835  1-151 HTECD94 1943 527210 AC025963 8836  1-151 HTECD94 1943 527210 AC009451 8837  1-151 HTECD88 1944 527214 AC024631 8838  1-560 HTECD88 1944 527214 AC017098 8839  1-560 HTECD88 1944 527214 AC024631 8840  1-263 HTECD88 1944 527214 AC017098 8841  1-869 1451-4175 HTECD88 1944 527214 AC024631 8842  1-869 1451-4174 HTECD88 1944 527214 AC017098 8843  1-263 HTECD70 1945 527203 AC013471 8844  1-243 3350-3433 HTECD65 1946 533795 AL157899 8845  1-119 4379-4589 HTECD65 1946 533795 AL137800 8846  1-119 4380-4590 HTECD65 1946 533795 AL157899 8847  1-489 540-886 HTECD65 1946 533795 AL137800 8848  1-489  540-2889 HTECD15 1948 523029 AC019082 8849  1-405 HTECD15 1948 523029 AC019082 8850  1-136 545-583  824-1177 HTECC71 1949 508142 AC060234 8851  1-364 HTECC45 1950 508124 AC034305 8852  1-320 HTECC45 1950 508124 AC034305 8853  1-539 HTECC26 1951 508144 AL158090 8854  1-168 2574-2660 3463-3623 HTECC09 1952 678659 AC069004 8855  1-91 238-330 1468-1597 1773-1835 2685-2851 2987-3081 3275-3440 4518-4928 6204-6550 6951-7273 7923-8577 HTECC09 1952 678659 AC069004 8856  1-816 HTECC08 1953 960439 AC008397 8857  1-436 HTECC08 1953 960439 AC008397 8858  1-314 HTECC08 1953 960439 AC008397 8859  1-555 HTECA39 1955 508132 AC036150 8860  1-412 HTBCA39 1955 508132 AP001883 8861  1-412 HTECA39 1955 508132 AC036150 8862  1-496  541-1674 HTECA39 1955 508132 AP001883 8863  1-461 HTECA39 1955 508132 AC036150 8864  1-461 HTECA39 1955 508132 AP001883 8865  1-496  541-1674 HTEBJ02 1960 921321 AL031727 8866   1-1383 HTEBJ02 1960 921321 AL031727 8867  1-576 HTEAX06 1962 960792 AC015559 8868  1-949 HTEAX06 1962 960792 AC015559 8869  1-65  86-509  733-1178 2992-3574 4191-4337 4759-4850 6000-6163 6241-6337 6731-6852 6932-7048 7138-7271 8386-8513 9167-9300 9384-9468 9527-9830 10006-10582 11005-11153 11315-11469 11660-11810 14929-15256 15410-15569 16041-16200 16626-16799 17095-17498 17712-18272 HTEAX06 1962 960792 AC015559 8870  1-188 1981-2138 3446-3545 3751-3867 3900-4028 4262-4369 HTEAV22 1963 679394 AC016757 8871  1-1823 HTEAV22 1963 679394 AC016757 8872   1-1229 2106-2702 3129-4275 HTEAR93 1967 503298 AC009967 8873  1-411 1914-2289 2844-2962 3628-4209 4664-4925 5258-5353 HTEAR93 1967 503298 AC009967 8874  1-241 348-492 1563-1872 1875-2138 HTEAR93 1967 503298 AC009967 8875  1-315 HTEAG47 1971 503623 AL139384 8876  1-939 HTEAG47 1971 503623 AL162711 8877  1-939 1988-2462 5032-5242 HTEAG47 1971 503623 AC011695 8878  1-939 HTEAG47 1971 503623 AL139384 8879  1-475 HTEAG47 1971 503623 AL162711 8880  1-310 HTEAG47 1971 503623 AL139384 8881  1-198 HTEAG47 1971 503623 AL162711 8882  1-198 HTEAG47 1971 503623 AC011695 8883  1-198 HTEAG47 1971 503623 AC011695 8884  1-475 HTEAG08 1972 960469 AC069236 8885  1-329 HTEAG08 1972 960469 AC069236 8886  1-454 HTEAB50 1973 724751 AL391056 8887  1-162 524-688 735-874 1577-1774 2049-2216 2395-2540 3191-3424 HTEAB50 1973 724751 AC007779 8888  1-162 524-688 749-849 1579-1776 2050-2217 2396-2541 3192-3425 HTEAB50 1973 724751 AC007779 8889  1-130 HSWBY36 1975 708291 AL122125 8890  1-465 HSWBY36 1975 708291 AL122125 8891  1-586 HSWBE29 1977 412991 AC016310 8892   1-1198 HSWBE29 1977 412991 AC016310 8893  1-531 HSWAS65 1978 953051 AC027146 8894  1-155 281-963 1320-2717 HSWAS65 1978 953051 AC027146 8895   1-2324 2582-2898 3329-3548 4330-4523 4816-4920 5735-5913 7687-7814 8125-8911 9575-9620 HSWAS18 1979 666302 AC015734 8896  1-498 HSWAS18 1979 666302 AC015734 8897   1-1814 HSWAS18 1979 666302 AC015734 8898  1-626 HSWAR63 1980 471236 AC023572 8899   1-1010 HSWAR63 1980 471236 AC025630 8900  1-663 HSWAR63 1980 471236 AL158197 8901   1-1678 HSWAR63 1980 471236 AC010554 8902   1-1242 1316-3871 4275-5565 6216-6811 7004-7388 7749-8799  9220-10381 10766-12026 12271-13076 HSWAR63 1980 471236 AL158197 8903  1-260 HSWAR63 1980 471236 AC010554 8904  1-368 HPWSA52 1983 727294 AC023293 8905   1-1823 1896-2248 2687-2854 3435-3673 3752-3855 5351-5412 5579-5661 5664-6092 6986-7089 7968-8147 HPWSA52 1983 727294 AL035699 8906   1-1823 1896-2248 2687-2854 3433-3671 3750-3853 5349-5410 5577-5659 5662-6090 7966-8145 HPWSA52 1983 727294 AC023293 8907   1-1845 1919-2936 HPWSA52 1983 727294 AL035699 8908   1-1845 1919-2936 HPWDE86 1986 785710 AC021124 8909   1-1473 1741-2513 2636-3258 3403-3998 5728-6283 6454-6541 6613-7768 8422-8995 9025-9187  9699-10397 11541-11606 11644-11887 13552-14227 14437-15311 15960-16131 17491-17894 17906-18148 18243-20300 HPWDE86 1986 785710 AC008592 8910   1-1473 1741-2513 2636-3258 3403-3998 5728-6283 6454-6541 6613-7768 8422-8995 9025-9187  9699-10397 11541-11606 11644-11887 13577-14227 14437-15311 15960-16131 17491-17894 17906-18148 18243-22141 HPWDE86 1986 785710 AC008821 8911   1-1473 1741-2513 2636-3258 3403-3998 5729-6284 6455-6542 6614-7768 8422-8995 9025-9187 9699-10397 11540-11605 11643-11886 13551-14226 14436-15310 15959-16130 17489-17892 17904-18146 18241-19429 HPWDE86 1986 785710 AC008924 8912   1-1473 1741-2513 2636-3258 3403-3997 5728-6283 6454-6541 6613-7768 8422-8995 9025-9187  9699-10397 11541-11606 11644-11887 13577-14227 14437-15311 15960-16131 17491-17894 17906-18148 18243-22140 HPWDE86 1986 785710 AC021124 8913   1-1496 HPWDE86 1986 785710 AC008592 8914   1-1495 HPWDE86 1986 785710 AC008821 8915   1-1495 HPWDE86 1986 785710 AC008924 8916   1-1495 HPWCJ90 1987 789170 AC024191 8917  1-42 1672-1837 2662-3033 4555-4909 5629-6051 HPWCJ90 1987 789170 AC024191 8918  1-636 HPWCJ90 1987 789170 AC024191 8919  1-109 HPWBF35 1989 707514 AC018476 8920  1-347 HPWBF35 1989 707514 AC007949 8921   1-1359 HPWBF35 1989 707514 AC018477 8922  1-345 HPWAT23 1991 676323 AC068550 8923  1-851  939-1165 1537-2159 2587-2619 HPWAT23 1991 676323 AC007933 8924  1-304 HPWAT23 1991 676323 AC015912 8925  1-851 939-1165 1537-2159 2587-2619 HPWAT23 1991 676323 AC068550 8926  1-532 HPWAT23 1991 676323 AC068550 8927  1-479 HPWAT23 1991 676323 AC007933 8928  1-532 HPWAT23 1991 676323 AC015912 8929  1-532 HPWAT23 1991 676323 AC007933 8930  1-482 HPWAT23 1991 676323 AC015912 8931  1-479 HPWAJ85 1992 535157 Z95115 8932  1-808  845-2003 HPWAJ85 1992 535157 Z95115 8933  1-123 1133-1262 2633-2792 3108-3261 4574-5008 5437-5789 6397-6617 6951-7387 8434-8511 8730-8794 HPWAJ85 1992 535157 Z95115 8934  1-693 HPWAJ39 1993 575271 AC073177 8935  1-315 HPWAJ39 1993 575271 AC016905 8936  1-319 HPWAJ39 1993 575271 AC016905 8937  1-258 HPWAJ39 1993 575271 AC016905 8938  1-719 HPWAI05 1994 932627 AC017006 8939  1-564 HPWAI05 1994 932627 AC017006 8940  1-375 HPWAG31 1996 693618 AC018695 8941  1-470 HPWAG31 1996 693618 AC009068 8942  1-463 HPWAG31 1996 693618 AC018695 8943  1-129 HPWAG31 1996 693618 AC009068 8944  1-129 HPVAH71 1997 829301 AC021225 8945   1-2009 HPVAH71 1997 829301 AC007881 8946   1-1775 1871-3872 HPVAH71 1997 829301 AC007881 8947  1-101 HPVAH71 1997 829301 AC007881 8948  1-179 1488-2112 2156-3167 HPVAH41 1998 848632 AC023055 8949  1-817 1052-1362 1416-1580 1660-1798 1995-2102 2315-5348 6011-6166 6325-6676 6848-7254 7391-7453 HPVAH41 1998 848632 AC023055 8950  1-300 HPVAH41 1998 848632 AC023055 8951  1-646 HPRTI54 2003 728812 AC074120 8952  1-963 HPRTI54 2003 728812/ AP001818 8953  1-963 HPRTI54 2003 728812 AC074120 8954  1-738 HPRTI54 2003 728812 AP001818 8955  1-1024 HPRTI16 2004 667652 AL109928 8956  1-55 140-468  845-1039 2611-3094 3270-3416 5144-5386 6727-6949 7289-7483 7526-7651 10478-10559 13709-13761 13774-14390 15428-15686 17608-17682 23419-24008 HPRTI16 2004 667652 AL109928 8957  1-200 HPRTI16 2004 667652 AL109928 8958  1-131 2091-2573 HPRCV66 2005 320393 AC007377 8959   1-1104 1155-1427 4071-4160 4296-4421 HPRCV66 2005 320393 AC010447 8960  1-792 1169-1441 3979-4068 4204-4329 HPRCV66 2005 320393 AC007377 8961  1-618 HPRCV66 2005 320393 AC010447 8962  1-525 HPRCV66 2005 320393 AC007377 8963  1-525 HPRCV66 2005 320393 AC010447 8964  1-618 HPRCT83 2006 780264 AC007182 8965   1-1014 4968-5234 5805-6546 7479-8153 9443-9916 13555-13984 16814-17618 18231-18666 21045-21485 22412-23012 23014-23411 24103-24320 31987-32500 37576-37704 39352-39698 40342-40425 43454-43595 43627-44110 44718-45133 45471-45741 45986-46107 HPRCT83 2006 780264 AC007182 8966  1-323 HPRCT83 2006 780264 AC007182 8967  1-476 HPRCN03 2007 925420 AC004056 8968  1-529 HPRCN03 2007 925420 AC004056 8969  1-384 HPRCN03 2007 925420 AC004056 8970  1-270 HPRCL72 2009 766311 AF276255 8971  1-107 198-359 2503-3020 5027-6174 KPRCL72 2009 766311 AC015709 8972  1-107 198-359 2503-3020 5026-6173 HPRCD11 2012 967762 AC010645 8973   1-1261 HPRCD11 2012 967762 AC010645 8974  1-763 1255-1379 HPRCD11 2012 967762 AC010645 8975   1-1412 HPRCC22 2013 526623 AL158815 8976  1-258 1168-1273 1506-1763 3756-5057 5749-5893  6020-10468 HPRCC22 2013 526623 AC012634 8977   1-2422 HPRCC22 2013 526623 AC005601 8978   1-2422 HPRCC22 2013 526623 AL035587 8979  1-258 1168-1273 1493-1763 3756-5492 5749-5893  6020-10468 HPRCC22 2013 526623 AL158815 8980  1-306 HPRCC22 2013 526623 AL158815 8981  1-606 HPRCC22 2013 526623 AC012634 8982  1-240 HPRCC22 2013 526623 AC012634 8983  1-435 HPRCC22 2013 526623 AC005601 8984  1-240 HPRCC22 2013 526623 AC005601 8985  1-435 HPRCC22 2013 526623 AL035587 8986  1-606 HPRCC22 2013 526623 AL035587 8987  1-296 HPRBI87 2016 695116 AC012618 8988   1-1525 HPRBI87 2016 695116 AC062036 8989  1-134 343-404 622-764 1703-1852 1920-4557 5206-5421 HPRBI87 2016 695116 AC062036 8990  1-316 HPRBH80 2017 781636 AC068212 8991  1-851 HPRBH80 2017 781636 AC004582 8992  1-851 HPRBH80 2017 781636 AC068212 8993  1-227 1252-1834 HPRBH80 2017 781636 AC004582 8994  1-227 1252-1810 HPRAV80 2018 781637 AC019071 8995  1-173 594-708 1259-1460 1857-2014 2036-2449 3537-3910 5801-8095 8166-9964 10231-10812 HPRAV80 2018 781637 AC019071 8996  1-440 HPRAN50 2020 724753 AC011244 8997  1-377 HPRAN50 2020 724753 AL161433 8998  1-348 HPRAN50 2020 724753 AL009030 8999  1-377 HPRAN50 2020 724753 AL133255 9000  1-348 HPRAN50 2020 724753 AL157879 9001  1-350 HPRAN50 2020 724753 AL161433 9002  1-627 HPRAN50 2020 724753 AL009030 9003  1-573 HPRAN50 2020 724753 AL133255 9004  1-572 HPRAN50 2020 724753 AL157879 9005  1-572 HPRAG73 2022 764757 AC009985 9006  1-867  902-1299 HPRAG73 2022 764757 AC009985 9007  1-370 HPRAF86 2024 784594 AC018494 9008  1-604 HPRAF86 2024 784594 AC018494 9009  1-435 HPMSH94 2026 796839 AP001033 9010  1-609 HPMSH94 2026 796839 AC015955 9011  1-616 HPMSH94 2026 796839 AP001033 9012  1-324 HPMSH94 2026 796839 AC015955 9013  1-96  643-1148 1742-2072 2248-2716 3978-4071 5368-8195 HPMSH94 2026 796839 AC015955 9014  1-314 HPMSB35 2027 707476 AC069240 9015  1-655  693-1132 1637-1983 2129-2540 HPMSB35 2027 707476 AL080279 9016  1-655  693-1132 1637-1983 2129-2540 HPMSB35 2027 707476 AC069240 9017  1-69 154-406 641-789 1249-1488 1646-2009 HPMSB35 2027 707476 AL080279 9018  1-277 HPMSB35 2027 707476 AC069240 9019  1-277 HPMSB35 2027 707476 AL080279 9020  1-69 154-406 641-789 1249-1488 1646-2009 HPMMK05 2028 928283 AP001265 9021  1-799 HPMMK05 2028 928283 AP000751 9022  1-25  577-1096 1319-5338 HPMMK05 2028 928283 AP001265 9023   1-1848 HPMMK05 2028 928283 AP000751 9024  1-384 HPMMK05 2028 928283 AP000751 9025   1-1849 HPMMB08 2029 957945 AL121918 9026  1-759  870-1328 HPMMB08 2029 957945 AC021670 9027  1-759  870-1328 HPMMB08 2029 957945 AL121918 9028  1-414 HPMMB08 2029 957945 AC021670 9029  1-533 HPMKP06 2030 933895 AC034210 9030  1-462 HPMKP06 2030 933895 AC018791 9031   1-1961 HPMKP06 2030 933895 AC016627 9032   1-1961 HPMKP06 2030 933895 AC018791 9033  1-448 HPMKP06 2030 933895 AC016627 9034  1-448 HPMKC05 2031 930874 AC009966 9035  1-821 HPMKC05 2031 930874 AC009966 9036  1-115 HPMKC05 2031 930874 AC009966 9037  1-512 HPMJT12 2032 969483 AC009622 9038  1-109  530-1348 1382-1410 HPMJT12 2032 969483 AF216667 9039  1-819 HPMJT12 2032 969483 AF257497 9040  1-135  539-1357 1391-1419 HPMJT12 2032 969483 AF216667 9041  1-89 HPMJK11 2034 965636 AF252825 9042  1-518 HPMJI11 2036 965627 AL162379 9043  1-271 419-828 1228-1729 4082-4171 HPMJI11 2036 965627 AL162379 9044  1-161 HPMJE06 2037 939682 AC025006 9045  1-811 HPMJE06 2037 939682 AC025006 9046  1-549 558-731 1577-1719 HPMJE06 2037 939682 AC025006 9047  1-293 HPMGO88 2041 463906 AC023389 9048  1-466 HPMGO88 2041 463906 AC023389 9049  1-465 HPMGO88 2041 463906 AC022169 9050  1-466 HPMGO88 2041 463906 AC022169 9051  1-986 HPMGO88 2041 463906 AC022169 9052  1-998 HPMGJ16 2043 662021 AC023508 9053  1-216 HPMGJ16 2043 662021 AC023508 9054  1-670 HPMFL73 2046 867670 AC005103 9055  1-940 HPMFL73 2046 867670 AF047825 9056  1-940 HPMFL73 2046 867670 AC005103 9057  1-770 HPMFL73 2046 867670 AC005103 9058  1-88 HPMFL73 2046 867670 AF047825 9059  1-770 HPMFC02 2047 920327 AL365261 9060  1-853 HPMFB26 2048 867674 AC004873 9061  1-345  484-2275 HPMFB26 2048 867674 AL034380 9062  1-345 484-2275 HPMFB26 2048 867674 AL034380 9063  1-768 1259-1628 1650-2209 2292-2397 2433-2587 2660-2791 3615-3861 3936-4479 4621-4806 6158-6592 6828-6934 7507-8214 8433-9310 10436-11557 HPMFB26 2048 867674 AC004873 9064  1-768 1259-1628 1650-2209 2292-2397 2433-2587 2694-2801 3604-3858 3936-4479 4608-4872 6158-6592 7507-8214 8433-9310 10436-11557 HPMEG77 2049 772503 AL135793 9065  1-124 3436-4154 4447-5170 HPMEG77 2049 772503 AL135793 9066  1-142 HPMDP10 2051 968350 AL109754 9067  1-170 1357-1493 2395-3335 HPMDP10 2051 968350 AL109754 9068  1-317 HPMDF06 2052 954567 AC068644 9069   1-1496 HPMDF06 2052 954567 AC068644 9070  1-474 HPMAH85 2060 783344 AC018870 9071  1-492 HPMAH85 2060 783344 AC018515 9072  1-490 HPMAH85 2060 783344 AC018870 9073  1-355 HPMAH85 2060 783344 AC018515 9074  1-355 HPMAH56 2061 867711 AC019225 9075  1-393 HPMAH56 2061 867711 AL355990 9076  1-393 HPMAH56 2061 867711 AL137790 9077  1-393 HPMAH56 2061 867711 AC010535 9078  1-393 HPMAH56 2061 867711 AC019225 9079  1-195 HPMAH56 2061 867711 AL137790 9080  1-195 HPMAH56 2061 867711 AC010535 9081  1-195 HPLBW22 2063 679217 AL390760 9082  1-405 509-556 1117-1214 HPLBW22 2063 679217 AL390760 9083  1-870 HPLBW22 2063 679217 AL390760 9084  1-372 HPLBT54 2065 731065 AC027620 9085  1-604 HPLBT54 2065 731065 AC027620 9086  1-218 HPLBT53 2066 728517 AL096838 9087  1-693 1224-1924 HPLBT53 2066 728517 AL117391 9088  1-693 1224-1924 HPLBT53 2066 728517 AL096838 9089  1-131 HPLBT53 2066 728517 AL117391 9090  1-131 HPLBT53 2066 728517 AL096838 9091  1-439 HPLBT53 2066 728517 AL117391 9092  1-439 HPLBS41 2067 712707 AL158203 9093  1-573  882-1629 1937-3057 3512-5443 HPLBO90 2069 787208 AC010997 9094  1-886 HPLBO90 2069 787208 AL390034 9095  1-886 HPLBO90 2069 787208 AC010997 9096  1-211 HPLBN79 2070 781854 AC019175 9097  1-925 HPLBN79 2070 781854 AL356738 9098  1-925 HPLBN79 2070 781854 AC019175 9099  1-523 HPLBN79 2070 781854 AL356738 9100  1-300 HPLBN79 2070 781854 AC019175 9101  1-300 HPLBN79 2070 781854 AL356738 9102   1-1556 2168-2385 HPLAX14 2072 727885 AC005073 9103  1-447  940-1180 1852-2062 2064-2154 2609-2977 3455-4244 4796-5220 6485-6924 8360-8685 8734-9287  9704-10448 11084-12000 12226-13392 13703-13772 13805-14443 14470-14888 15137-16367 16448-17023 17096-17156 17259-18000 18350-18690 18962-19128 19420-19573 19792-20077 20124-22431 22573-23150 23223-23837 24074-24172 24218-24750 24811-25121 26008-27281 27312-27680 27891-28841 29378-29581 31206-31718 HPLAX14 2072 727885 AC005071 9104  1-447 1852-2062 2064-2154 2609-2977 3455-4244 4796-5218 6593-6924  9903-10133 11084-12000 12226-13392 13703-13772 13805-14443 14470-14888 15137-16367 16448-17010 17096-17156 17259-18000 18350-18690 18962-19128 19420-19573 19792-20077 20124-22431 22573-23150 23223-23837 24074-24172 24218-24750 24819-25110 26008-27281 27312-27680 27891-28841 29378-29581 31206-31718 HPLAX14 2072 727885 AC005073 9105  1-853 HPLAX14 2072 727885 AC005073 9106   1-3333 3556-3754 3816-7381 7384-7601 7635-8330 8572-8879 8917-9030 9088-9191 9671-9908  9911-13281 13403-13828 14157-15040 15737-16040 16205-16293 17878-18795 19197-19455 19962-21676 HPLAX14 2072 727885 AC005071 9107   1-3015 3238-3428 3498-7063 7066-7283 7317-8012  9349-12963 13085-13595 13839-14722 15397-15722 15887-15975 17560-18477 18879-19130 19644-21358 HPLAX14 2072 727885 AC005071 9108   1-1300 HPLAV44 2073 715732 AC010645 9109   1-1261 HPLAV44 2073 715732 AC010645 9110  1-125  617-1379 HPLAV44 2073 715732 AC010645 9111   1-1412 HPJFA10 2075 963322 AC009299 9112  1-607 HPJFA10 2075 963322 AC009299 9113  1-465 HPJFA10 2075 963322 AC009299 9114  1-475 HPJEV95 2076 929723 AL359456 9115  1-711 HPJEV95 2076 929723 AL390724 9116  1-633 HPJEV95 2076 929723 AL390724 9117  1-368 HPJEV95 2076 929723 AL359456 9118   1-1365 HPJET11 2078 965894 AP001270 9119  1-961 HPJET11 2078 965894 AP001270 9120  1-344 HPJET11 2078 965894 AP001270 9121  1-527 HPJES17 2079 859867 AP001857 9122  1-444 HPJES17 2079 859867 AC015703 9123  1-444 HPJES17 2079 859867 AP001857 9124  1-54 1030-1290 HPJEL02 2080 918315 AC025014 9125   1-1195 1827-2531 4783-5133 5139-5379 5902-6081 6463-7267 7466-7724 8041-8216 8269-9037  9310-10364 10545-10988 11353-12100 HPJEL02 2080 918315 AC011850 9126  1-416 1048-1381 4025-4374 4380-4621 5927-6305 HPJEL02 2080 918315 AC011850 9127  1-334 HPJEL02 2080 918315 AC020590 9128  1-397 HPJEL02 2080 918315 AL162451 9129  1-416 1052-1446 2106-2304 4264-4614 4620-4861 5947-6495 HPJEL02 2080 918315 AC012661 9130  1-396 HPJEL02 2080 918315 AC011850 9131  1-660 HPJEL02 2080 918315 AC025014 9132   1-1181 HPJEL02 2080 918315 AC011850 9133  1-247 HPJEL02 2080 918315 AL162451 9134  1-249 HPJEL02 2080 918315 AC020590 9135  1-659 HPJEL02 2080 918315 AC012661 9136  1-486 HPJEG53 2081 974074 AC006137 9137  1-508 HPJEG53 2081 974074 AL050328 9138  1-508 HPJEG53 2081 974074 AC006137 9139  1-266 1353-1457 1654-1954 HPJEG53 2081 974074 AL050328 9140  1-323 1647-1959 HPJDT03 2083 922815 AC009143 9141  1-459 HPJDT03 2083 922815 AC009123 9142  1-459 3173-3221 5754-6155 HPJDP54 2084 949149 AC022608 9143  1-531 HPJDP54 2084 949149 AC021472 9144  1-531 HPJDP54 2084 949149 AC069078 9145  1-531 HPJDP54 2084 949149 AC022608 9146  1-301 HPJDP54 2084 949149 AC022608 9147  1-537 HPJDP54 2084 949149 AC021472 9148   1-1124 HPJDP54 2084 949149 AC021472 9149  1-301 HPJDP54 2084 949149 AC069078 9150   1-1124 HPJDP54 2084 949149 AC069078 9151  1-301 HPJDC01 2086 915056 AL357517 9152  1-607 HPJDC01 2086 915056 AL356792 9153  1-607 HPJDC01 2086 915056 AL357517 9154  1-532 HPJDC01 2086 915056 AL357517 9155  1-221 HPJDC01 2086 915056 AL356792 9156  1-532 HPJDC01 2086 915056 AL356792 9157  1-221 HPJCT81 2089 494874 AC068243 9158  1-652 HPJCT81 2089 494874 AC068243 9159  1-119 HPJCT81 2089 494874 AC068243 9160  1-420 HPJCT26 2090 559949 AC022064 9161  1-130  781-1384 3527-3569 HPJCT26 2090 559949 AC022064 9162  1-198 HPJCS73 2091 975087 AC008013 9163  1-751  869-1288 1741-2134 3713-4192 4219-4525 5032-5188 6221-6459 7627-7887 8458-9081 9227-9966 10464-10713 11232-11320 11620-11777 11791-12453 12643-13059 14536-14632 15693-16508 16536-17099 17433-17823 18365-18520 19494-19542 19895-20386 20452-21075 21128-21475 22370-22928 22994-23030 HPJCS73 2091 975087 AC009533 9164  1-221 367-759 1212-1606 3182-3992 4509-4666 4820-4982 5711-5948 7122-7382 7953-8576 8722-9484  9977-10227 10746-10834 11133-11288 11304-11966 12156-12572 14044-14140 14735-15547 15575-16138 16472-16862 17405-17560 18541-18589 18938-19448 20178-20525 21420-21971 22037-22073 22331-22434 22548-22685 22842-23316 23334-23726 25414-26133 26228-26338 26375-26622 26657-26756 27017-27239 27287-27340 27456-27676 27850-28149 28593-28639 28670-29013 29189-29345 29359-30420 HPJCS73 2091 975087 AC008013 9165  1-294 HPJCS73 2091 975087 AC008013 9166  1-106 220-357  575-1050 1060-1459 3153-3870 3965-4359 4392-4496 4756-4977 5025-5078 5198-5418 5593-5895 6301-6763 6941-8173 8913-9547  9927-10355 10651-11058 11461-11749 HPJCS73 2091 975087 AC009533 9167  1-636 HPJCS32 2093 699046 AC024922 9168  1-274 RPJCS32 2093 699046 AC024922 9169  1-274 HPJCL55 2095 670083 AC068280 9170  1-895 HPJBS35 2100 867818 AC016276 9171  1-431 HiPJBS35 2100 867818 AC015557 9172  1-436 HPJBS35 2100 867818 AC015557 9173  1-495 HPJBL76 2101 769889 AC007066 9174   1-1543 HPJBL76 2101 769889 AC018466 9175   1-1543 HPJBL76 2101 769889 AC007066 9176  1-785 KPJBL76 2101 769889 AC007066 9177   1-1761 HPJBL76 2101 769889 AC018466 9178   1-1761 HPJBL76 2101 769889 AC018466 9179  1-785 HPJBK25 2103 974606 AC005077 9180  1-540 HPJBK25 2103 974606 AC005077 9181  1-124 HPJBK14 2104 974593 AC005202 9182  1-604 HPJBK14 2104 974593 AC005202 9183  1-98 HPJBH45 2105 717088 AC073089 9184  1-681 HPJBH45 2105 717088 AC006480 9185  1-681 KPIBH45 2105 717088 AC073089 9186  1-238 HPJBH45 2105 717088 AC006480 9187  1-218 HPJBH45 2105 717088 AC006480 9188  1-493 HPJAU73 2107 806718 AC011689 9189   1-1216 HPJAU73 2107 806718 AC078939 9190   1-1496 HPJAU73 2107 806718 AC011043 9191  1-712  904-1867 1874-1906 2000-2124 2337-3891 HPJAU73 2107 806718 AC011841 9192  1-710  902-1864 1997-2121 2334-3824 4232-5905 HPJAU73 2107 806718 AC078939 9193  1-646  837-1797 1804-1836 1930-3820 4161-5834 HPJAU73 2107 806718 AC078939 9194   1-1358 HPJAU73 2107 806718 AC011043 9195  1-105 HPJAU73 2107 806718 AC078939 9196  1-906 HPJAU73 2107 806718 AC011841 9197  1-541 HPJAU73 2107 806718 AC011841 9198  1-105 HPJAU73 2107 806718 AC078939 9199  1-564 HPJAU73 2107 806718 AC078939 9200  1-105 HPJAP92 2108 806718 AL353687 9201  1-430 HPJAP92 2108 887830 Z97832 9202  1-430 HPJAP92 2108 806718 AL353687 9203  1-262 HPJAP92 2108 887830 Z97832 9204  1-262 HPJAN69 2110 754858 AC025957 9205  1-345 HPJAN67 2111 751384 AL139244 9206  1-161 1052-1592 3665-4095 4361-4549 HPJAN67 2111 751384 AC004962 9207  1-83 719-835 1648-1811 2702-3242 5315-5745 6011-6199 HPJAN67 2111 751384 AL139244 9208  1-506 HPJAN67 2111 751384 AC004962 9209   1-1876 HPJAN57 2112 734503 AC007747 9210  1-433 HPJAN57 2112 734503 AL158136 9211  1-433 HPJAN57 2112 734503 AC007747 9212  1-623 HPJAN57 2112 734503 AL158136 9213  1-623 HPJAJ20 2113 669000 AP000584 9214  1-564  648-2086 3513-3644 HPJAJ20 2113 669000 AC011256 9215  1-564  648-2086 3514-3645 HPJAJ20 2113 669000 AP000588 9216  1-564  648-2086 3513-3644 HPJAJ20 2113 669000 AP002815 9217  1-564  648-2086 3513-3644 HPJAJ20 2113 669000 AP000584 9218  1-386 HPJAJ20 2113 669000 AC011256 9219  1-386 HPJAJ20 2113 669000 AP000588 9220  1-386 HPJAJ20 2113 669000 AP002815 9221  1-386 HPJAE51 2114 725761 AL353654 9222  1-392  842-1387 HPJAE51 2114 725761 AC004842 9223  1-392  842-1387 HPJAE51 2114 725761 AL035696 9224  1-392  842-1387 HPJAE51 2114 725761 AL353654 9225  1-169 179-295 HPJAE51 2114 725761 AC004842 9226  1-168 178-294 HPJAE51 2114 725761 AL035696 9227  1-162 HPJAA27 2115 419786 AC074007 9228  1-531 HPJAA27 2115 419786 AL356953 9229  1-531 HPJAA27 2115 419786 AC018896 9230  1-531 HPICG93 2116 887817 AL356975 9231  1-447 HPICG93 2116 887817 AL357812 9232  1-423 HPIBT62 2119 743135 AC068150 9233  1-62 2884-2997 3285-3503 4212-4325 5273-5353 7542-7640 7721-8853 HPIBT62 2119 743135 AC068150 9234  1-766 HPIBO89 2120 786741 AL355102 9235  1-98 763-882 1106-1289 1883-2041 2351-2629 3424-3590 4426-4726 5712-8082 HPJBO89 2120 786741 AL355102 9236  1-101 1847-2078 HPIBO89 2120 786741 AL355102 9237   1-2260 HPIBI89 2121 867845 AC009696 9238  1-149 5 1 1-650  806-1203 1520-2566 2570-2737 3468-3611 3880-4009 4098-4206 HPIBC93 2123 785971 Z97630 9239  1-418 2009-2216 2619-2865 3398-3578 4946-5048 5089-5669 7182-7343 7476-7560 7718-7895 7913-8163 8257-8378 8422-8957 HPIBC93 2123 785971 Z97630 9240   1-2182 HPIBB45 2124 867850 AL110504 9241   1-5312 HPIBB32 2126 698901 AC040962 9242  1-323 HPIBB32 2126 698901 AL161903 9243  1-415 HPIBB32 2126 698901 AL021366 9244  1-415 HPIBB32 2126 698901 AL050332 9245  1-415 HPIBB32 2126 698901 AL161903 9246  1-183 HPIBB32 2126 698901 AC040962 9247  1-111 HPIBB32 2126 698901 AL161903 9248  1-111 HPIBB32 2126 698901 AL021366 9249  1-194 HPIBB32 2126 698901 AL021366 9250  1-111 HPIBB32 2126 698901 AL050332 9251  1-111 HPIBB32 2126 698901 AL050332 9252  1-194 HPIAW91 2128 790033 AC004200 9253  1-719 HPJAW91 2128 790033 AC011858 9254  1-719 HPIAW91 2128 790033 AB023056 9255  1-719 HPIAV06 2129 935111 AC008542 9256  1-41 499-841  945-1795 1847-2073 2214-2453 3031-3131 3396-4444 4470-5202 5863-6644 7027-7181 7474-7771 7857-8016 8110-8448 HPIAV06 2129 935111 AC023788 9257  1-71  998-1207 4649-5094 5184-5215 5490-5821 6192-6604 6708-6745 6917-7852 7993-8232 8809-8909  9174-10222 10248-10976 11637-12418 12801-12955 13248-13545 13631-13790 13884-14221 HPIAV06 2129 935111 AC008404 9258  1-446 537-568  843-1166 1553-1961 2065-2915 2967-3193 3334-3573 4515-5563 5589-6320 6980-7761 8144-8298 8591-8888 8974-9133 9227-9566 HPJAV06 2129 935111 AC008404 9259  1-393 HPIAV06 2129 935111 AC023788 9260  1-393 HPIAQ70 2130 973604 AC008751 9261  1-930 HPHSB91 2133 790313 AC069100 9262  1-331 HPHSB91 2133 790313 AC069100 9263  1-101 HPHSA94 2135 793084 AC068386 9264  1-278 HPHSA94 2135 793084 AC017015 9265  1-278 HPHSA94 2135 793084 AC068386 9266  1-269 HPHSA94 2135 793084 AC017O15 9267  1-267 HPHSA94 2135 793084 AC017015 9268  1-557 HPFMG06 2137 933696 AL138904 9269  1-474  705-1039 1625-1999 HPFMG06 2137 933696 AL354990 9270  1-474 705-1039 1625-1999 HPFMG06 2137 933696 AL138904 9271  1-511 HPFMG06 2137 933696 AL354990 9272  1-511 HPFMG06 2137 933696 AL138904 9273  1-210 HPFMG06 2137 933696 AL354990 9274  1-210 HPFMB10 2138 961758 AC016135 9275  1-845 HPFMB10 2138 961758 AC018512 9276  1-776 HPFDX38 2139 709302 AC023631 9277   1-2429 HPFDX38 2139 709302 AC011962 9278   1-2428 HPFCZ82 2140 780198 AC048350 9279  1-900 HPFCZ82 2140 780198 AC037193 9280  1-876 HPFCZ82 2140 780198 AC008042 9281  1-688 1078-1977 HPFCZ82 2140 780198 AC037193 9282  1-218 961-991 4864-5402 HPFCZ82 2140 780198 AC037193 9283  1-688 HPFCZ60 2141 430125 AC010611 9284  1-694 HPFCZ60 2141 430125 AC010255 9285  1-694 HPFCZ60 2141 430125 AC010611 9286  1-190 HPFCZ60 2141 430125 AC010255 9287  1-190 HPFCZ10 2142 968360 AC024493 9288  1-337 HPFCZ10 2142 968360 AL359983 9289  1-337 HPFCZ10 2142 968360 AL357555 9290  1-337 HPFCP53 2145 526574 AC023329 9291  1-101 HPFCP53 2145 526574 AC069380 9292  1-238 HPFCP53 2145 526574 AL162583 9293  1-130 HPFCL56 2148 732601 AC027270 9294  1-154 744-867 1696-1817 1958-2117 2143-2244 3812-3907 4266-4379 4520-4734 4822-4936 5686-5748 5820-5952 6060-6191 7271-8847 9423-9518 10087-10163 10751-10891 12158-12252 12330-12717 13997-14286 14515-14846 14946-15228 16306-16744 16881-17380 18392-18826 19323-19437 19503-20654 20746-21268 21327-21815 22145-22695 22742-23675 23977-24173 HPFCL56 2148 732601 AP002748 9295  1-551  598-1452 HPFCL56 2148 732601 AC027270 9296  1-154 HPFCL56 2148 732601 AP002748 9297  1-196 HPFCL56 2148 732601 AC027270 9298  1-282 HPFCA01 2151 928672 AC005531 9299  1-873 HPFCA01 2151 928672 AC073184 9300  1-873 HPFCA01 2151 928672 AC005531 9301  1-934 HPFCA01 2151 928672 AC073184 9302  1-934 HPELD12 2152 969248 AC000384 9303  1-73 373-694 880-951 1368-1531 1991-2111 2578-2725 3044-3210 4123-4292 4550-4761 HPELD12 2152 969248 AC000384 9304  1-765 1018-1580 HPEKI04 2153 926104 AC009985 9305  1-506 515-927  977-1407 HPEKI04 2153 926104 AC010794 9306  1-506 515-927  977-1407 HPEKI04 2153 926104 AC009985 9307  1-540 HPEKI04 2153 926104 AC010794 9308  1-540 HPEKI04 2153 926104 AC009985 9309  1-156 HPEKI04 2153 926104 AC010794 9310  1-156 HPEKE01 2154 914414 AC055804 9311  1-528 HPEKE01 2154 914414 AL357976 9312  1-528 HPEKE01 2154 914414 AC055804 9313  1-352 HPEKE01 2154 914414 AL357976 9314  1-231 HPEKE01 2154 914414 AC055804 9315  1-176 HPEKE01 2154 914414 AL357976 9316  1-352 HPEBT82 2155 524246 AC018865 9317  1-466 HPEBT82 2155 524246 AC018865 9318  1-218 HPEBT49 2159 530021 AC046171 9319  1-373 HPEBT49 2159 530021 AC046171 9320  1-209 1274-1611 HPEBT49 2159 530021 AC046171 9321  1-208 HPEBT34 2160 706836 AC009677 9322  1-360 HPEBT14 2161 535061 AL358573 9323  1-245 HPEBT14 2161 535061 AL139113 9324  1-246 HPEBT14 2161 535061 AL358573 9325  1-576 HPEBT14 2161 535061 AL139113 9326  1-576 HPEBL08 2164 960240 AC007684 9327  1-38 2047-2188 2599-2984 3134-4018 4336-4377 4685-4800 6534-6618 8404-8480 8739-8851 12237-12815 14345-14412 14489-14605 15097-15445 15469-15664 16908-17608 18139-18250 19641-19696 HPEBL08 2164 960240 AC007684 9328   1-1190 HPEBL08 2164 960240 AC007684 9329  1-394 429-990 1194-1451 HPEBG10 2167 867888 AL356133 9330  1-293 HPEBG10 2167 867888 AL356133 9331  1-503 HPEBA61 2169 742251 AC007036 9332  1-78 HPEBA61 2169 742251 AC007036 9333  1-225 HPEBA05 2170 928027 AC026647 9334  1-379 HPEBA05 2170 928027 AL359754 9335  1-374 1483-1516 HPEBA05 2170 928027 AL159175 9336  1-374 1483-1516 HPEBA05 2170 928027 AL359754 9337  1-673 HPEBA05 2170 928027 AC026647 9338  1-672 HPEBA05 2170 928027 AL159175 9339  1-673 HPBAA57 2174 514231 AC018662 9340  1-784  890-1375 1837-2156 2324-2766 3080-3286 4028-4155 4903-5424 5721-6302 6782-7063 7153-7571 7923-8053 11271-11598 HPEAA57 2174 514231 AC008039 9341  1-784  890-1375 1837-2156 2324-2766 3080-3286 4028-4155 4905-5426 5723-6304 6784-7065 7155-7573 7925-8055 11273-11600 HPEAA57 2174 514231 AC018662 9342  1-419 HPEAA57 2174 514231 AC008039 9343  1-418 HPDWR11 2176 965249 AC016344 9344  1-647 HPDWR11 2176 965249 AC018796 9345  1-643 HPDWR11 2176 965249 AC010857 9346  1-643 HPDWR11 2176 965249 AC018796 9347  1-422 HPDWR11 2176 965249 AC010857 9348  1-422 HPDWN05 2177 928563 AC009871 9349  1-599  896-1375 HPDWN05 2177 928563 AC009812 9350  1-599  896-1375 HPDWN05 2177 928563 AC009871 9351  1-99 HPDWN05 2177 928563 AC009871 9352   1-4119 HPDWN05 2177 928563 AC009812 9353  1-99 HPDWN05 2177 928563 AC009812 9354  1-74 277-452  718-5961 HPDRR06 2181 968601 AC073389 9355   1-1034 HPDRR06 2181 968601 AL359074 9356  1-92 1559-2178 2181-3214 HPDRR06 2181 968601 AC073389 9357  1-615 HPDRR06 2181 968601 AL359074 9358  1-652 HPDRR06 2181 968601 AL359074 9359  1-465 596-748 790-866 HPDRN07 2182 951838 AC073930 9360   1-2176 HPDRN07 2182 951838 AC073865 9361   1-2174 HPDRN07 2182 951838 AC073930 9362  1-449 HPDRN07 2182 951838 AC073865 9363  1-849 HPDRN07 2182 951838 AC073930 9364  1-849 HPDRN07 2182 951838 AC073865 9365  1-449 HPDRG01 2183 914416 AL356152 9366  1-773 HPDRG01 2183 914416 AL158082 9367  1-773 HPDRG01 2183 914416 AL158082 9368  1-153 HPDRG01 2183 914416 AL356152 9369  1-602 HPDPS12 2184 969342 AC073487 9370  1-375  893-4326 4474-5168 5186-6317 6538-6708 6755-7192 7587-9453 HPDPS12 2184 969342 AC023055 9371  1-246  485-1179 1198-2329 2550-2720 2767-3204 3603-5469 HPDPS12 2184 969342 AC073487 9372  1-646 HPDPS12 2184 969342 AC023055 9373  1-428 HPDPS12 2184 969342 AC023055 9374  1-245 HPDPP12 2185 969341 AP001097 9375  1-481 HPDPP12 2185 969341 AC021474 9376  1-579 HPDPP12 2185 969341 AP000931 9377  1-579 HPDPP12 2185 969341 AP001097 9378  1-125 HPDPP12 2185 969341 AC021474 9379  1-125 HPDPP12 2185 969341 AP000931 9380  1-453 HPDPP12 2185 969341 AC021474 9381  1-451 HPDOW10 2187 961782 AC026088 9382  1-494 HPDOF11 2189 965491 AL390721 9383  1-912 HPDOF11 2189 965491 AL021997 9384  1-233  901-1252 1400-1967 2803-2939 3883-4324 4569-5633 7594-8505  8713-11051 HPDOF11 2189 965491 AL390721 9385   1-2339 HPCTK02 2190 917480 AL158074 9386  1-42  468-1132 1279-1726 HPCTK02 2190 917480 AC013579 9387  1-42  468-1129 1276-1721 HPCTK02 2190 917480 AL158074 9388  1-117 HPCTK02 2190 917480 AC013579 9389  1-740 1026-1325 1835-2355 HPCTC04 2192 925777 AC006198 9390  1-972 HPCTC04 2192 925777 AL079338 9391  1-972 HPCTC04 2192 925777 AC006198 9392  1-597 HPCTC04 2192 925777 AL079338 9393  1-572 HPCTC04 2192 925777 AC006198 9394  1-187 HPCTC04 2192 925777 AL079338 9395  1-187 HPCOV68 2195 911075 AC026794 9396  1-1027 BPCOV68 2195 911075 AC004SOO 9397   1-1004 HPCOV68 2195 911075 AC026794 9398  1-102 HPCOV68 2195 911075 AC004500 9399  1-102 HPCAO89 2196 946913 AP001583 9400  1-56 1227-1357 3023-3526 4699-4820 8676-8831 9495-9648 11657-12553 HPCAO89 2196 946913 AP001583 9401  1-124 HPCAF65 2199 573368 AL139816 9402  1-305 1879-2426 2774-3145 HPCAB54 2201 728857 AC074194 9403  1-424 HPCAB54 2201 728857 AC074194 9404  1-580 HOVEV01 2203 914553 AL359092 9405  1-116 HOVEV01 2203 914553 AC009453 9406  1-143 HOVEV01 2203 914553 AC025036 9407  1-148 HOVEV01 2203 914553 AC016327 9408  1-125 HOVEV01 2203 914553 AC022231 9409  1-151 HOVEV01 2203 914553 AC022232 9410  1-152 HOVEV01 2203 914553 AC048342 9411  1-130 HOVEV01 2203 914553 AC048342 9412  1-118 HOVEU06 2205 933737 AL356240 9413  1-406 HOVEU06 2205 933737 AC021202 9414  1-406 HOVEO04 2206 926209 AC009763 9415  1-37 612-789 1387-1596 2329-2749 HOVEO04 2206 926209 AC008751 9416  1-37 610-787 1383-1592 2325-2745 HOVEO04 2206 926209 AC009763 9417  1-577 HOVEO04 2206 926209 AC008751 9418  1-575 HOVDD10 2209 961887 AC013555 9419  1-589 HOVDD10 2209 961887 AC013555 9420   1-3604 HOVCO50 2211 932544 AC011743 9421  1-310 1101-3106 3478-4052 4404-7119 7315-7492 7591-7677 7702-8144 8377-8410 8495-9117 9222-9386  9534-10411 10577-10783 HOVCO50 2211 932544 AC009948 9422  1-195 436-930 2047-2366 3235-3687 4129-4425 5291-7148 7368-7956 8617-9180 9370-9679 10470-12475 12847-13421 13773-15659 15770-16487 16683-16860 17070-17512 17745-17778 17863-18485 18590-18754 18902-19779 19945-20150 20271-20444 HOVCO50 2211 932544 AC011743 9423  1-521 HOVCO50 2211 932544 AC011743 9424  1-564 HOVCO50 2211 932544 AC009948 9425  1-521 HOVCO50 2211 932544 AC009948 9426  1-588 HOVCM77 2213 772208 AC013452 9427  1-31 1058-1160 3236-3744 4308-4731 4830-5384 5754-5981 HOVCM77 2213 772208 AC036102 9428  1-31 1059-1161 3237-3745 4309-4732 4831-5385 5755-5982 HOVCM77 2213 772208 AC069073 9429  1-808 HOVCM77 2213 772208 AC069073 9430  1-192 HOVCM03 2214 924196 AC008026 9431  1-691 HOVCM03 2214 924196 AC018636 9432   1-1712 1781-2220 2775-3125 4267-4398 4943-5119 5395-6479 6593-6736 8582-8759  9851-10352 10560-11273 11554-11699 13092-13782 13894-14174 14184-16225 HOVCM03 2214 924196 AC023982 9433  1-614 HOVCM03 2214 924196 AC018636 9434  1-687 HOVCM03 2214 924196 AC018636 9435  1-382 HOVCM03 2214 924196 AC023982 9436  1-439 HOVCI89 2215 786917 Z99289 9437  1-165 2231-2370 3629-5021 5116-6302 HOVCI89 2215 786917 Z99289 9438  1-282 HOVCI89 2215 786917 Z99289 9439  1-110 HOVBK69 2220 757594 AC048347 9440  1-537 HOVBK69 2220 757594 AC009319 9441  1-536 HOVBK69 2220 757594 AC048347 9442  1-299 HOVBK69 2220 757594 AC048347 9443  1-147 HOVBK69 2220 757594 AC009319 9444  1-303 HOVBK69 2220 757594 AC009319 9445  1-193 HOVBK38 2221 956238 AC006251 9446  1-442 1222-2085 2175-2409 3314-3530 5391-5542 5894-6556 7350-7446 8455-8563 9344-9752 10389-10933 14295-14691 14714-14982 17146-17504 21039-21150 21264-21477 21774-21936 HOVBK38 2221 956238 AC006251 9447  1-323 HOVBK38 2221 956238 AC006251 9448  1-289 371-500 1108-1518 2170-2282 3050-3088 4088-4145 4455-4519 4790-5047 5422-5806 5933-6678 6727-7444 HOVBI67 2223 751665 AC004975 9449   1-1090 1399-1517 2019-2457 4390-4835 5859-6444 8606-8937 8979-9108 10450-10806 10853-12075 12331-13044 13247-13372 19647-21441 HOVAZ65 2226 750273 AP000627 9450   1-1082 HOVAZ65 2226 750273 AP000730 9451   1-1836 1991-2508 HOVAZ65 2226 750273 AP000870 9452   1-1836 1991-2508 HOVAY42 2229 713812 AC023046 9453  1-364 HOVAY42 2229 713812 AC023046 9454  1-105 HOVAY42 2229 713812 AC023046 9455  1-210 HOVAY03 2230 921959 AP002789 9456  1-308 HOVAY03 2230 921959 AP002789 9457  1-247 HOVA025 2232 678163 AC026149 9458  1-374 HOVA025 2232 678163 AC026149 9459  1-352 HOVA025 2232 678163 AC026149 9460  1-518 HOVAC77 2238 578783 AC023158 9461  1-396 HOVAB61 2242 578791 AL096827 9462  1-667 HOVAB61 2242 578791 AL096827 9463  1-139 HOVAB61 2242 578791 AL096827 9464   1-1322 HOOKF10 2243 961499 AC023183 9465  1-493 HOOKF10 2243 961499 AC026678 9466  1-493 HOOKF10 2243 961499 AC026365 9467  1-493 HOOKF10 2243 961499 AC026678 9468  1-480 HOOKF10 2243 961499 AC023183 9469  1-480 HOOKF10 2243 961499 AC026365 9470  1-480 HOOJU04 2245 925774 AC048331 9471  1-59 317-593 HOOJU04 2245 925774 AC024530 9472  1-59 317-593 HOOJU04 2245 925774 AC061705 9473  1-59 317-593 HOOJU04 2245 925774 AC048331 9474  1-572 HOOJU04 2245 925774 AC024530 9475  1-91 184-640  785-2468 2676-2898 HOOJU04 2245 925774 AC061705 9476  1-91 184-640  785-2468 2676-2898 HOOJU04 2245 925774 AC024530 9477  1-453 HOOJU04 2245 925774 AC061705 9478  1-572 HOOJN04 2246 925783 AL035684 9479  1-55 2293-2465 3852-3951 5485-5583 6544-6662 7772-7947 8614-9071 10099-10166 10618-10710 10715-11030 12681-12959 13821-13979 16726-17090 17491-18237 19028-19138 20072-20129 22633-22838 26307-31140 HOOJN04 2246 925783 AL035684 9480  1-573 HOOJN04 2246 925783 AL035684 9481  1-498 HOOJH05 2248 928627 AC021154 9482  1-935 HOOJH05 2248 928627 AC011452 9483  1-934 HOOJH05 2248 928627 AC011452 9484  1-101 HOOIG03 2251 922510 AC016883 9485  1-429 HOOIG03 2251 922510 AC073155 9486  1-429 HOOIG03 2251 922510 AC018714 9487  1-429 HOOHP02 2252 917424 AC013669 9488  1-487 HOOHP02 2252 917424 AC013669 9489  1-181 291-782 2171-2360 2703-3570 4336-4689 5249-5785 5817-6442 6834-7458 HOOAB23 2255 522227 AC051654 9490  1-129  832-1405 HOOAB23 2255 522227 AC068345 9491  1-855 1558-2131 HOOAB23 2255 522227 AC068345 9492  1-203 HONAK10 2257 968610 AC023105 9493   1-3282 3292-5377 HONAK10 2257 968610 AC023105 9494   1-1914 1958-2384 HONAH06 2258 936029 AC022286 9495   1-1132 HONAH06 2258 936029 AC005355 9496  1-33 HONAH06 2258 936029 AC002369 9497   1-1333 1663-1760 2438-2530 4503-5088 HONAH06 2258 936029 AC005730 9498   1-1130 HONAH06 2258 936029 AC002369 9499  1-228 HONAH06 2258 936029 AC005730 9500  1-887 HONAH06 2258 936029 AC005730 9501  1-192 HONAE50 2259 723571 AC073160 9502  1-749 HONAE50 2259 723571 AC027507 9503  1-749 HONAE50 2259 723571 AC027507 9504  1-158 HONAB50 2259 723571 AC073160 9505  1-158 HONAD65 2260 747152 AL138904 9506  1-474  705-1039 1625-1999 HONAD65 2260 747152 AL354990 9507  1-474  705-1039 1625-1999 HONAD65 2260 747152 AL138904 9508  1-511 HONAD65 2260 747152 AL354990 9509  1-511 HONAD65 2260 747152 AL138904 9510  1-210 HONAD65 2260 747152 AL354990 9511  1-210 HOGCW89 2264 973227 AC015988 9512  1-736 HOGCW89 2264 973227 AP001491 9513  1-736 HOGCW89 2264 973227 AC015988 9514  1-222 HOGCW89 2264 973227 AC015988 9515  1-831 HOGCW89 2264 973227 AP001491 9516  1-831 HOGCW89 2264 973227 AP001491 9517  1-229 HOGCT13 2265 657284 AC012431 9518  1-234 240-488  879-1648 1672-1969 2213-3083 HOGCT13 2265 657284 AC024483 9519  1-249 640-1409 1433-1730 1974-2844 HOGCT13 2265 657284 AC010300 9520  1-412  810-1279 1502-1630 2316-2382 3130-4416 4989-5077 5090-5599 5990-6759 6783-7080 7321-8191 HOGCT13 2265 657284 AC010300 9521  1-399 HOGCH05 2269 930813 AL354797 9522  1-663 HOGCH05 2269 930813 AL359692 9523  1-663 HOGCH05 2269 930813 AC013740 9524  1-663 HOGCH05 2269 930813 AL359692 9525  1-431 HOGCH05 2269 930813 AL354797 9526  1-117 HOGCH05 2269 930813 AL359692 9527  1-117 HOGCH05 2269 930813 AC013740 9528  1-117 HOGCH05 2269 930813 AC013740 9529  1-431 HOGCC63 2272 745130 AC021885 9530  1-443 HOGCC63 2272 745130 AC021885 9531  1-43 176-469 2722-3017 3881-4005 HOGBE27 2275 682232 AC021573 9532   1-2701 2726-2818 2920-3387 HOGBE27 2275 682232 AC021573 9533  1-602 HOGAM56 2276 908904 AC021344 9534  1-717 HOGAI73 2277 764490 AC007215 9535   1-2096 HOGAI73 2277 764490 AC007688 9536  1-271  276-3205 HOGAI73 2277 764490 AC007215 9537  1-168 HOGAI73 2277 764490 AC007688 9538  1-776 HOGAD77 2281 772319 AC073650 9539  1-936 HOGAD77 2281 772319 AC009417 9540  1-556 HOGAD77 2281 772319 AC073650 9541  1-572 HOGAD77 2281 772319 AC009417 9542  1-572 HODKG07 2322 951875 AC072035 9543  1-786 HODKG07 2322 951875 AC072035 9544  1-689 HODGL88 2327 859300 AC020988 9545  1-886  900-3110 HODGL88 2327 859300 AC020988 9546  1-318 HODGL88 2327 859300 AC020988 9547  1-320 HODFY10 2329 963350 AC015464 9548  1-718 HODFY10 2329 963350 AL133284 9549  1-718 HODFY10 2329 963350 AC015464 9550  1-779 HODFY10 2329 963350 AC015464 9551  1-940 HODFY10 2329 963350 AL133284 9552   1-3485 8125-8521 14884-15094 17015-17375 18078-21722 21824-22143 23417-24165 HODFY10 2329 963350 AL133284 9553  1-782 HODFX19 2330 842138 AC011462 9554  1-756 1096-1314 2617-2717 3158-3842 5564-5805 6037-6404 6761-6817 6951-7090 7229-7499 HODFX19 2330 842138 AC011462 9555  1-133 HODFX04 2332 926278 AP001469 9556  1-421 1062-1420 1705-1867 1978-2089 2804-2943 3323-3420 4630-4970 5685-8599  9683-11324 11404-12154 13101-13635 13740-14218 15283-15751 15842-16654 17611-17746 18380-19010 19268-19404 19634-19850 21352-21872 23386-23623 23640-24466 25541-25784 26154-26288 27551-27876 28169-28210 28657-28687 28993-29095 30196-30400 30800-31304 HODFX04 2332 926278 AP001469 9557  1-465 HODFX04 2332 926278 AP001469 9558  1-470 HODFW40 2334 859320 AC008927 9559  1-555 HODFW40 2334 859320 AC008589 9560  1-555 HODFW40 2334 859320 AC008779 9561  1-555 HODFW40 2334 859320 AC008927 9562  1-303 HODFW40 2334 859320 AC008589 9563  1-303 HODFW40 2334 859320 AC008779 9564  1-303 HODFR85 2335 783789 AL356136 9565  1-539 HODFR85 2335 783789 AC025014 9566   1-1196 HODFR85 2335 783789 AP001896 9567   1-1199 HODFR85 2335 783789 AL356136 9568  1-428 HODFR85 2335 783789 AC025014 9569  1-494 HODFR85 2335 783789 AP001896 9570  1-494 HODFL37 2336 948703 AC018620 9571  1-489 HODFL37 2336 948703 AC018620 9572  1-518 HODFJ11 2337 966065 AC015896 9573  1-671 1241-1647 HODFJ11 2337 966065 AC015896 9574  1-935 HODFI66 2338 974317 AC067831 9575  1-527 HODFI66 2338 974317 AC063944 9576  1-527 HODFH45 2339 974916 AL121595 9577  1-598 HODFH45 2339 974916 AL121595 9578  1-232 HODFG82 2340 779191 AC074124 9579  1-553 HODFG82 2340 779191 AC074124 9580  1-122 HODFD73 2343 909812 AL050332 9581  1-187 311-458  667-1020 2447-2586 HODFD73 2343 909812 AL161903 9582  1-187 311-458  667-1020 2448-2587 HODFD73 2343 909812 AL050332 9583  1-89 HODFC79 2344 774156 AL354665 9584   1-1880 HODFC79 2344 774156 AL356112 9585   1-1880 HODFC79 2344 774156 AL354665 9586  1-504 HODFC79 2344 774156 AL356112 9587  1-504 HODFC79 2344 774156 AL354665 9588  1-336 HODEU01 2346 915176 AC073577 9589   1-1184 HODEU01 2346 915176 AC073577 9590  1-100 HODET07 2347 952194 AF129408 9591  1-432 HODET07 2347 952194 AF129408 9592  1-663 HODES10 2348 963474 AC004928 9593  1-624 HODES10 2348 963474 AC004928 9594  1-205 HODEK82 2350 779245 AC016457 9595  1-782 HODEK82 2350 779245 AC060231 9596  1-782 HODEK82 2350 779245 AC022538 9597  1-782 HODEK82 2350 779245 AC016457 9598  1-453 HODEK82 2350 779245 AC060231 9599  1-453 HODEK82 2350 779245 AC022538 9600  1-453 HODEA14 2351 859375 AC004821 9601  1-100 2352-2466 2802-2941 2960-3163 4980-5083 6842-6968 8774-9008 10405-10540 11412-11517 11577-11682 13279-13409 HODEA14 2351 859375 AC004821 9602  1-274 HODDS89 2353 531075 AL359453 9603  1-489 HODDS89 2353 531075 AL359096 9604  1-489 HODDS89 2353 531075 AC053522 9605  1-489 HODDS89 2353 531075 AC015973 9606  1-489 HODDS89 2353 531075 AL359453 9607  1-331 HODDS89 2353 531075 AL359096 9608  1-331 HODDS89 2353 531075 AC053522 9609  1-331 HODDS89 2353 531075 AC015973 9610  1-331 HODDS74 2354 765863 AC016957 9611  1-429 571-934 1473-2003 2118-2519 3522-3589 HODCZ39 2358 875811 AC008990 9612  1-579 1410-1855 2046-4238 4245-4589 4723-5500 5796-6198 HODCZ39 2358 875811 AC010620 9613  1-834 1126-1489 1779-2082 2087-2615 2924-3005 3288-3484 6156-6584 6654-6857 7053-7451  9732-10222 10604-12196 28404-28529 29430-29840 30786-31233 39537-40066 40600-41177 42007-42545 42643-44839 44846-45190 45324-46101 46397-46799 HODCZ39 2358 875811 AC008990 9614  1-95 1041-1794 HODCZ39 2358 875811 AC008990 9615  1-530 HODCZ39 2358 875811 AC010620 9616  1-95 1040-1793 HODCY73 2359 764543 AC025992 9617  1-521 HODCY73 2359 764543 AL356957 9618  1-690 HODCY73 2359 764543 AL358813 9619  1-450 HODCY73 2359 764543 AL162612 9620   1-1431 1501-1692 1855-3146 3686-4006 4703-6498 HODCY73 2359 764543 AC018593 9621   1-1430 1500-1691 1854-3144 3684-3985 4696-6493 HODCY73 2359 764543 AL358813 9622  1-756 HODCY73 2359 764543 AC025992 9623   1-1496 HODCY73 2359 764543 AL356957 9624   1-1494 HODCY73 2359 764543 AL162612 9625  1-384 HODCY73 2359 764543 AL358813 9626   1-1002 HODCY73 2359 764543 AL162612 9627  1-850 HODCY73 2359 764543 AC018593 9628  1-332 HODCY73 2359 764543 AC018593 9629   1-1496 HODCY32 2360 859543 AC023867 9630  1-611 HODCY32 2360 859543 AC023867 9631  1-648 HODCY32 2360 859543 AC009495 9632   1-1907 2428-2566 3458-4205 5930-6606 6608-6806 7787-8721 12114-12354 12826-12943 14443-14643 14777-15780 16627-16758 16802-17297 21703-21946 22365-24099 HODCY32 2360 859543 AC009495 9633  1-476 HODCW83 2361 781287 AL035367 9634  1-78 174-305 1281-1442 1519-1552 2373-2498 2594-2818 2976-3043 4113-4271 4346-4441 4979-5277 5571-5718 5960-6104 7479-7833 8245-8371 8551-8718 8949-9503 9663-9777 10007-10128 10242-10323 10596-10905 11404-12232 HODCW83 2361 781287 AC020567 9635   1-1875 1958-2262 2388-2630 2707-2875 HODCW83 2361 781287 AC020567 9636  1-99 HODCO15 2363 660502 AC018379 9637  1-52  865-1157 1271-1363 1369-1933 3640-3798 4011-4819 5198-6057 6253-8477 HODCJ84 2364 973286 AC013429 9638  1-687 HODCJ84 2364 973286 AC008265 9639  1-687 HODCJ84 2364 973286 AC013429 9640  1-410 HODCJ84 2364 973286 AC013429 9641  1-544 HODCJ84 2364 973286 AC008265 9642  1-544 HODCJ84 2364 973286 AC008265 9643  1-410 HODCC05 2365 932633 AC006946 9644  1-57  724-1966 4206-4370 HODBZ85 2367 784526 AC024994 9645  1-384 468-807 1074-1320 HODBZ85 2367 784526 AL133340 9646  1-384 468-807 1074-1320 HODBZ85 2367 784526 AC024994 9647  1-392 1812-2867 HODBZ85 2367 784526 AL133340 9648  1-392 1812-2867 HODBU72 2369 766284 AC072044 9649  1-379 HODBU72 2369 766284 AC026876 9650  1-379 HODBU72 2369 766284 AC009893 9651  1-379 HODBF33 2373 702750 AC073640 9652  1-317  530-1570 1730-2268 5937-6065 HODBF17 2374 529389 AL157875 9653  1-571 HODBF17 2374 529389 AL157875 9654   1-1818 HODBD93 2375 792579 AC027105 9655  1-567 HODBD93 2375 792579 AL122023 9656  1-567 HODBD93 2375 792579 AL132838 9657  1-567 HODBC42 2377 529635 AP002020 9658  1-29  634-2028 HODBC42 2377 529635 AC004067 9659  1-29  634-2028 HODBC42 2377 529635 AP002020 9660  1-141 HODBC42 2377 529635 AP002020 9661  1-386 HODBC42 2377 529635 AC004067 9662  1-386 HODBA48 2378 721931 AC005046 9663  1-157 1370-1522 1727-1861 2415-2630 3229-3373 3584-3817 6852-7006 7432-7608 9282-9534 10097-10628 10841-11055 11740-11963 13041-13323 13451-13850 14382-15096 16075-16749 18154-18346 18531-18857 19624-20680 20738-21207 22021-22555 22673-23076 25746-25974 26932-27715 27740-30183 30458-30899 31160-32000 32177-32662 33181-33425 33436-33652 33857-34003 34289-34464 34518-34738 36446-37141 37163-38834 38961-39339 HODBA48 2378 721931 AC005046 9664  1-136 HODAV84 2381 592179 AL133514 9665  1-629 HODAV84 2381 592179 AL133514 9666  1-630 HODAK05 2384 932639 AC026405 9667   1-1145 1846-2312 3041-3568 4230-6044 6403-6576 9005-9592 10059-10472 10734-13322 HODAK05 2384 932639 AC026405 9668  1-526 HODAE72 2385 529638 AC021661 9669  1-196 HODAE72 2385 529638 AL356583 9670  1-196 HODAA92 2389 790588 AC026636 9671  1-234 HODAA80 2391 529560 AL354993 9672  1-882 HODAA80 2391 529560 AL354993 9673  1-101 HODAA80 2391 529560 AL354993 9674  1-111 HODAA69 2392 529563 AP000791 9675  1-772 HODAA69 2392 529563 AP002349 9676  1-768 HODAA69 2392 529563 AC007030 9677  1-773 HODAA54 2393 859582 AC026731 9678  1-256 HODAA21 2395 859583 AL035530 9679  1-303 736-986 10977-11340 13616-13896 15003-15115 15827-16799 17915-18493 21381-21837 22627-22812 22838-23836 24249-24953 25245-25435 27484-27678 28829-29505 30105-30641 32209-32582 32642-33135 33357-33685 34531-34948 38450-38642 39237-39536 40191-40354 42778-42866 43278-43368 43400-44302 44382-44960 45622-46160 46194-46311 HODAA21 2395 859583 AL035530 9680  1-592 HODAA21 2395 859583 AL035530 9681   1-1767 HODAA15 2396 523382 AL022068 9682  1-127 HODAA04 2398 927711 AL138713 9683  1-497 HODAA04 2398 927711 AL138713 9684  1-480 HOCPU05 2399 928651 AL022721 9685   1-1263 6140-6293 8003-8156 9128-9256  9263-10128 11307-11562 13464-13807 14210-14510 15844-17115 17822-19417 20123-20680 21428-21754 25071-25264 25391-25481 25570-25604 30944-31465 34638-34933 35608-35955 36105-36346 38876-39207 44154-44338 44424-44513 44661-45127 45137-45929 HOCPU05 2399 928651 AL022721 9686  1-117 HOCPH02 2400 917453 AL359674 9687  1-684 HOCPH02 2400 917453 AL359674 9688  1-456 HOCPF02 2401 917630 AL359372 9689   1-1054 2139-2246 4030-4427 6093-6259 HOCPF02 2401 917630 AL050343 9690   1-1054 2139-2246 4030-4428 6094-6260 HOCPF02 2401 917630 AL359372 9691  1-31  42-315 HOCPF02 2401 917630 AL050343 9692  1-274 HOCPF02 2401 917630 AL050343 9693  1-742 HOCOV07 2402 951744 AC026974 9694  1-813 HOCOV07 2402 951744 AL079341 9695  1-813 HOCOV07 2402 951744 AC026974 9696  1-306 HOCOV07 2402 951744 AL079341 9697  1-306 HOCMM01 2403 914464 AC078864 9698  1-954 HOCMM01 2403 914464 AC019244 9699  1-829 HOCMI24 2404 878363 AC023046 9700   1-1593 HOCMI24 2404 878363 AC023046 9701  1-353 HNOAD04 2407 926258 AC069278 9702  1-741 HNOAD04 2407 926258 AC069278 9703  1-698 1008-1383 HNOAD04 2407 926258 AC069278 9704   1-2222 HNNNB08 2408 957719 AC005281 9705  1-276  835-5981 5998-8928 HNNNB08 2408 957719 AC005281 9706  1-529 HNNNA07 2409 899742 AC037444 9707  1-625 HNNNA07 2409 899742 AC013698 9708  1-625 HNNNA07 2409 899742 AC037444 9709  1-285 HNNNA07 2409 899742 AC037444 9710  1-316 HNNNA07 2409 899742 AC013698 9711  1-285 HNNNA07 2409 899742 AC013698 9712  1-316 HNIAB92 2410 683077 AC078916 9713  1-364 HNIAB92 2410 683077 AC022305 9714  1-686 HNIAB92 2410 683077 AC072032 9715  1-364 HNIAB92 2410 683077 AC078916 9716  1-288 HNIAB92 2410 683077 AC072032 9717  1-288 HNBVH02 2413 917719 AL355822 9718  1-103 170-600  780-1088 1296-1647 2086-2390 3428-3714 3745-4698  5342-10951 HNBVH02 2413 917719 AL117354 9719  1-103 170-600  780-1088 1296-1647 2085-2407 3742-4775 4783-4893  5339-10949 HNBVH02 2413 917719 AL355822 9720  1-689 HNBVH02 2413 917719 AL117354 9721  1-689 HNBVC03 2414 922402 AC017099 9722  1-396 510-858 1026-1198 2607-2761 HNBVC03 2414 922402 AC017099 9723  1-196 HNBUQ06 2415 933673 AC022558 9724  1-133 1253-1381 2940-3076 3160-3199 3860-3985 4129-4569 5374-5488 5932-7588 HNBUQ06 2415 933673 AC022558 9725  1-373 HNBUQ06 2415 933673 AC022558 9726  1-374 HNBUI10 2417 961734 AC010990 9727  1-227  339-1923 1947-2413 2498-2672 HLWFJ69 2418 754476 AC012169 9728  1-414 HLWFJ69 2418 754476 AC012169 9729  1-200 540-702 2463-2655 4388-4755 5077-5416 5954-6143 HLWEH10 2420 963548 AC016151 9730  1-593 HLWEH10 2420 963548 AC016147 9731  1-593 HLWEH10 2420 963548 AC011881 9732   1-1143 HLWEH10 2420 963548 AC024454 9733   1-1146 HLWEH10 2420 963548 AC000382 9734   1-1134 HLWEH10 2420 963548 AC016147 9735  1-406 HLWEH10 2420 963548 AC016147 9736  1-223 HLWEH10 2420 963548 AC011881 9737  1-224 HLWEH10 2420 963548 AC024454 9738  1-224 HLWEH10 2420 963548 AC000382 9739  1-223 HLWEH10 2420 963548 AC000382 9740   1-1424 HLWEA90 2421 787632 AC010582 9741  1-87  201-1019 HLWEA90 2421 787632 AL136040 9742  1-87  201-1019 HLWEA90 2421 787632 AC010582 9743  1-570 HLWEA90 2421 787632 AC010582 9744  1-172 HLWEA90 2421 787632 AL136040 9745  1-172 HLWEA90 2421 787632 AL136040 9746  1-558 HLWDD01 2423 915378 AL109757 9747  1-558 HLWDD01 2423 915378 AL031296 9748  1-670 1590-2584 3609-3751 4204-4803 4847-5271  9874-10146 11847-12328 12493-13051 13395-13635 15455-15917 17288-17739 18945-19908 21414-22006 27737-27823 35955-36575 36643-37204 37341-37504 39154-39312 41736-42263 47221-47669 47712-48167 50898-51095 51163-51655 51716-52580 52706-58181 HLWDD01 2423 915378 AL109757 9749  1-482 HLWDD01 2423 915378 AL031296 9750  1-274 HLWCN93 2426 791854 AL356915 9751  1-688 HLWCN93 2426 791854 AL356915 9752  1-339 HLWCN93 2426 791854 AL356915 9753  1-253 HLWCF33 2429 687995 AC018868 9754  1-99  586-1341 2056-2449 2920-3360 3386-3488 4490-5122 5574-5649 7802-7900 9752-9814 10688-11014 11951-12045 HLWCF33 2429 687995 AC018868 9755  1-554 HLWCF47 2430 720156 AC023331 9756  1-121  258-3102 4363-4509 HLWCE47 2430 720156 AC023331 9757  1-45  471-1400 1581-2065 2682-3136 4339-5870 HLWBW29 2433 690515 AL121586 9758  1-397 2315-2406 3620-4013 4016-4099 4277-4545 4635-4916 5001-5099 5203-5521 HLWBW29 2433 690515 AL139226 9759  1-397 2314-2405 3619-4012 4015-4098 4276-4544 4634-4846 HLWBW29 2433 690515 AL121586 9760  1-218 386-445  524-1437 1507-1603 1800-2130 2481-2687 3285-3720 4079-4447 4632-5281 5733-6062 6435-7005 7989-8263 8407-8736 8786-8848 8963-9148 10148-10245 10438-11523 11689-12039 12381-12673 13749-14001 14716-14838 15055-15209 15263-15441 15473-15610 HLWBW29 2433 690515 AL139226 9761  1-86 190-508 HLWBT09 2434 887877 AP000655 9762  1-447 HLWBT09 2434 887877 AC012153 9763  1-447 3188-3293 6053-6211 6320-6805 6922-7663 7858-7976 8361-8482 9276-9370 HLWBT09 2434 887877 AC012153 9764  1-267 HLWBS62 2435 743406 AC005203 9765  1-216 492-953 1282-1431 1754-1846 2011-2094 2599-2717 2956-3306 3685-4243 4636-4916 4919-5475 5711-8099 8218-9037  9387-10436 10500-11440 11934-12921 13353-13560 13759-13866 14223-14326 14799-15187 15528-15837 16093-16197 16539-16716 17686-17775 18652-18786 20304-20465 21288-21364 21996-22111 23463-23703 23726-24579 24595-24722 25683-25758 HLWBS62 2435 743406 AC006111 9766  1-216 492-953 1282-1431 1754-1846 2011-2094 2543-2661 2900-3250 3629-4187 4580-4860 4863-5419 5655-6300 6361-8043 8162-8981  9331-10380 10444-11384 11878-12865 13297-13504 13702-13809 14166-14269 14742-15130 15602-15772 16482-16659 17629-17718 18595-18729 20247-20408 21231-21307 21939-22054 23406-23646 23669-24522 25626-25701 HLWBS62 2435 743406 AC005203 9767  1-663 HLWBS62 2435 743406 AC006111 9768  1-663 HLWBR85 2436 784261 AC073573 9769  1-157  190-1625 HLWBR85 2436 784261 AC073573 9770  1-129  443-1256 HLWBR85 2436 784261 AC073573 9771   1-1487 HLWBJ65 2438 747784 AL049611 9772  1-165 335-911 1853-2122 5376-6516 HLWBH92 2439 791355 AC015461 9773  1-42  614-1073 1433-1570 2132-2699 2822-3332 3681-3973 4281-4618 5384-6480 6612-7384 8045-8651 8864-8986  9098-10018 10476-11001 11359-11552 11580-11802 12250-12674 12793-13281 14507-14719 15077-15520 16239-17705 HLWBH92 2439 791355 AL157394 9774  1-608 822-934 1055-1975 2433-2958 3316-3508 3537-3759 4207-4631 4750-5238 6464-6676 7034-7477 8196-9662 HLWBH92 2439 791355 AL157394 9775  1-773 HLWBF48 2441 721530 AC025230 9776  1-507 HLWBF48 2441 721530 AC025230 9777  1-320 HLWBE74 2442 887967 AC026529 9778  1-387 HLWBE74 2442 887967 AC026529 9779  1-116 HLWBC21 2443 869611 AC008870 9780  1-76 1811-2154 2232-2671 3021-3129 4039-4147 4436-4506 4859-5131 6200-6622 7373-7595 7729-8234 9030-9789 10164-10575 10878-14792 HLWBC21 2443 869611 AC009043 9781  1-226 409-741 1925-2135 3871-4214 4292-4731 5079-5187 6097-6205 6494-6564 6917-7189 8258-8680 9431-9653  9787-10292 11088-11847 12223-12634 12937-16851 HLWBC21 2443 869611 AC002400 9782  1-226 409-741 1926-2136 3872-4215 4293-4732 5080-5188 6098-6206 6495-6565 6918-7190 8259-8681 9432-9654  9788-10293 11090-11849 12225-12636 12939-16853 HLWBC21 2443 869611 AC009043 9783  1-523 HLWBC21 2443 869611 AC002400 9784  1-522 HLWBA27 2445 931387 AC073342 9785  1-164 208-280  349-1975 1978-2434 2614-2946 4135-9074 9200-9507 HLWBA27 2445 931387 AC073342 9786  1-434 HLWAS09 2447 625419 AC023300 9787  1-42 621-892 5228-5295 5624-5709 6898-7039 7372-7745 8210-8940 9110-9248 11554-11620 11800-12095 12143-12209 12240-12612 13239-13378 13766-13932 15723-16186 16578-16970 17992-18068 19055-19192 19207-19562 20293-20705 20784-20888 21589-21754 22112-22267 22754-23587 HLWAS09 2447 625419 AL390962 9788  1-393 HLWAS09 2447 625419 AC023545 9789  1-332  797-1527 1697-1835 4141-4207 4387-4682 4730-4796 4827-5199 5826-5965 6353-6519 8310-8773 9165-9557 10579-10655 11642-11779 11794-12149 12880-13292 13371-13474 14175-14340 14698-14853 15340-16173 HLWAS09 2447 625419 AL390962 9790  1-464 HLWAO67 2449 751503 AC023120 9791  1-113 1670-1968 2817-2876 3739-3958 4039-4861 8042-8236  9960-10253 10358-10487 11261-11363 12445-12554 17967-18436 19317-19470 19666-19900 20264-20363 20475-20779 25579-26082 26905-27377 27555-27983 28656-28997 29146-29769 30579-31170 31202-31625 32023-32698 34599-34740 34805-35520 35575-37925 HLWAO67 2449 751503 AC023120 9792   1-1768 HLWAO67 2449 751503 AC023120 9793  1-518 HLWAE09 2453 789030 AL162258 9794   1-1463 1779-2270 2460-2664 2763-3258 3293-4333 4480-5086 HLWAE09 2453 789030 AL162258 9795  1-245 HLWAD57 2454 734655 AL049651 9796  1-469 HLWAD33 2455 702317 AC015849 9797  1-458 HLWAD33 2455 702317 AC004675 9798  1-466 HLWAD33 2455 702317 AC004675 9799  1-250 HLWAD33 2455 702317 AC004675 9800  1-773 1224-1484 1586-2669 HLWAD32 2456 699158 AC069057 9801  1-366 HLWAD02 2457 919725 AC008005 9802  1-545 HLWAD02 2457 919725 AC019292 9803  1-545 HLWAD02 2457 919725 AC008005 9804  1-283 HLWAD02 2457 919725 AC008005 9805  1-333 2042-3121 3134-4497 4933-5401 HLWAD02 2457 919725 AC019292 9806  1-283 HLWAD02 2457 919725 AC019292 9807  1-333 2039-3118 3131-3936 HKZAH11 2458 965175 AL359092 9808  1-116 HKZAH11 2458 965175 AC009453 9809  1-143 HKZAH11 2458 965175 AC025036 9810  1-148 HKZAH11 2458 965175 AC011953 9811  1-126 HKZAH11 2458 965175 AC022231 9812  1-151 HKZAH11 2458 965175 AP001451 9813  1-96 HKZAH11 2458 965175 AC016327 9814  1-165 HKZAH11 2458 965175 AC048342 9815  1-130 HKZAH11 2458 965175 AP000562 9816  1-724 HKZAH11 2458 965175 AC016327 9817  1-195 HKZAH11 2458 965175 AC048342 9818  1-118 HKZAH11 2458 965175 AP000562 9819  1-187 HJMBX19 2459 668568 AC011184 9820  1-433 545-883 1218-1556 HJMBX19 2459 668568 AC011184 9821  1-331 HJMBS77 2460 772101 AC009902 9822  1-320 HJMBS77 2460 772101 AC009902 9823   1-1732 HJMBS10 2461 964464 AP000116 9824  1-606 HJMBS10 2461 964464 AP000192 9825  1-606 HJMBS10 2461 964464 AP000048 9826  1-606 HJMBQ90 2462 788834 AL162271 9827   1-1136 1294-1518 2224-2510 2907-3489 HJMBQ90 2462 788834 AC068198 9828  1-808  859-1169 1306-2443 2599-2823 3529-3815 4215-4401 4557-4741 HJMBQ90 2462 788834 AL162271 9829  1-113 HJMBQ90 2462 788834 AL162271 9830  1-45 291-609 HJMBQ90 2462 788834 AC068198 9831  1-45 294-612 HJMBN02 2463 919737 AC010687 9832  1-632 HJMBN02 2463 919737 AC011399 9833  1-847  995-1104 1510-2357 2363-2467 2608-3240 3319-4028 5266-5726 7081-7398 HJMBN02 2463 919737 AC005214 9834  1-847  995-1104 1510-2357 2363-2540 2608-3240 3319-4029 5268-5728 7082-8757 8896-9359 10246-10442 10573-10763 10952-11038 11298-11386 11406-12164 12287-13192 13285-13604 13686-14403 HJMBN02 2463 919737 AC010687 9835  1-711 HJMBN02 2463 919737 AC011399 9836  1-560 1032-1413 1565-1911 HJMBN02 2463 919737 AC010687 9837  1-847  995-1104 1510-2356 2362-2539 HJMBN02 2463 919737 AC005214 9838  1-193 HJMBN02 2463 919737 AC005214 9839  1-559 1031-1412 1564-1910 HJMBI93 2464 929114 AL031847 9840   1-1841 HJMAV93 2465 828110 AC025740 9841  1-84 504-619 2486-5330 5682-7115 HJMAV93 2465 828110 AC025740 9842  1-461 HJMAV93 2465 828110 AC025740 9843  1-772 HJMAU07 2466 961623 AC004493 9844  1-35 410-599 1161-1291 4637-5891 6021-6140 6276-8377  8478-15183 15896-17173 17337-17391 17567-17817 18166-19658 20060-20408 21099-21245 22688-23082 23890-24387 HJMAU07 2466 961623 AC004493 9845  1-942 HJMAQ86 2467 785410 AP001805 9846   1-2130 HJMAQ86 2467 785410 AC023532 9847   1-2132 5338-5376 HJMAQ86 2467 785410 U73643 9848   1-2131 5344-5373 HJMAQ86 2467 785410 AP001805 9849  1-692 HJMAQ86 2467 785410 AC023532 9850  1-692 HJMAQ86 2467 785410 U73643 9851  1-692 HJMAJ91 2469 811222 AP000579 9852  1-148  924-1039 2043-2371 3168-3291 3324-3436 3442-3596 4583-4741 5311-5502 5615-5693 5944-6637 7166-8217 HJMAJ91 2469 811222 AP000579 9853  1-485 HJMAI62 2470 742612 AC002325 9854  1-210  828-1009 1391-1843 2126-2699 3119-3263 3622-3964 3992-4139 5066-6149 HJMAI62 2470 742612 AC001644 9855  1-158 708-871 1883-2092 2710-2891 3273-3725 4008-4581 5001-5145 5504-6021 6948-8031 HJMAI62 2470 742612 AC002355 9856  1-116 669-833 1883-2079 2700-2882 3271-3733 4022-4177 5027-5176 5539-5908 5938-6070 7027-8066 HJMAI62 2470 742612 AC002325 9857   1-2217 2648-3015 3487-3706 4094-4549 5330-5457 5621-5743 7223-7371 10631-10827 HJMAI62 2470 742612 AC001644 9858  1-218 HJMAI62 2470 742612 AC001644 9859   1-2217 2648-3015 3487-3706 4094-4549 5330-5457 5621-5743 7223-7371 10632-10828 HJMAI62 2470 742612 AC002355 9860  1-186 HETJY68 2472 752542 AC021236 9861  1-64 107-782  957-1948 HETFF43 2477 529589 AC002430 9862  1-193 HETFF43 2477 529589 AC007384 9863  1-193 HETFF43 2477 529589 AC002430 9864   1-1417 HETFF43 2477 529589 AC002430 9865  1-772 HETFF43 2477 529589 AC007384 9866   1-1417 HETFF43 2477 529589 AC007384 9867  1-772 HETBM55 2482 929285 AC026565 9868  1-199 302-449  971-1329 1415-1771 HETBM55 2482 929285 AL391068 9869  1-199 302-449 972-1330 1416-1772 HETBM55 2482 929285 AC026565 9870  1-317 HETBM55 2482 929285 AL391068 9871  1-98 HETBM55 2482 929285 AL391068 9872  1-478  786-1282 HETAS81 2485 778539 AJ239326 9873  1-496 HETAS81 2485 778539 AJ239326 9874  1-485 HETAS62 2486 754155 AC024527 9875   1-1433 HETAS62 2486 754155 AC024527 9876  1-458  916-1327 2547-2905 3015-3726 4373-4406 HETAS62 2486 754155 AL135916 9877  1-506  579-1425 HETAS62 2486 754155 AL021368 9878  1-488  579-1425 HETAS62 2486 754155 AC024527 9879  1-461 HETAS62 2486 754155 AC024527 9880  1-84 HETAS62 2486 754155 AC024527 9881  1-536 HETAS62 2486 754155 AL135916 9882  1-459 HETAS62 2486 754155 AL135916 9883  1-395 HETAS62 2486 754155 AL021368 9884  1-395 HETAS62 2486 754155 AL021368 9885  1-459 HETAJ14 2487 660831 AL137801 9886  1-179 260-500 2213-2348 4736-5133 5208-5285 5508-5662 5773-5903 7130-8120 8349-8770  9477-10513 11808-11888 HETAJ14 2487 660831 AC011945 9887  1-28 255-408 519-649 1876-2866 3096-3518 4225-5262 6557-6637 HETAJ14 2487 660831 AL137801 9888  1-175 HETAJ14 2487 660831 AC011945 9889  1-175 HEQCCO1 2488 924849 AC004477 9890  1-326 1029-1626 2309-2345 2958-3015 3982-4124 5005-5248 5482-6071 6519-6577 7045-7136 7692-7780 8037-8184 9575-9866 10372-10789 11501-11618 HEQBG85 2492 827915 AC009471 9891  1-108 723-884 4822-6340  9727-10217 10407-10719 10931-11142 14095-14493 15086-15208 15529-15664 18304-18739 18985-19103 19756-22635 HEQBE71 2495 760305 AC012522 9892   1-1087 HEQBE71 2495 760305 AC006254 9893   1-1263 1513-2033 2070-2296 2334-2660 2830-4987 5578-6030 6277-6369 8894-9193 9213-9265 9347-9448 10205-10424 11055-11156 11776-11991 HEQBE71 2495 760305 AC012522 9894   1-1263 1513-2033 2070-2296 2334-2660 2830-3734 HEQBE71 2495 760305 AC012522 9895  1-453 HEQBE71 2495 760305 AC006254 9896  1-322 HEQAM59 2497 739220 AC010226 9897  1-575  642-1128 HEQAM59 2497 739220 AC010472 9898   1-1277 1339-1830 HEQAM59 2497 739220 AC008628 9899   1-1934 HEQAM59 2497 739220 AC026789 9900   1-1934 2001-2487 HEQAM59 2497 739220 AC022114 9901  1-576 HEQAM59 2497 739220 AC026789 9902  1-157 HEQAM59 2497 739220 AC010226 9903   1-1431 HEQAM59 2497 739220 AC010472 9904  1-243 HEQAM59 2497 739220 AC008628 9905  1-157 HEQAM59 2497 739220 AC026789 9906  1-914 HEPCB04 2502 941270 AL023581 9907  1-394 541-679 HEPBO85 2504 783362 AC010192 9908   1-1410 HEPBO85 2504 783362 AC010192 9909  1-844 HEPAX40 2506 535627 AP000872 9910  1-919 HEPAX40 2506 535627 AP001316 9911  1-918 HEPAX40 2506 535627 AC020735 9912  1-918 HEPAX40 2506 535627 AP000872 9913  1-239 HEPAX40 2506 535627 AP001316 9914  1-239 HEPAX40 2506 535627 AC020735 9915  1-239 HEPAP34 2509 703336 AC023500 9916  1-861 1078-1553 1584-2086 2457-5820 5956-6035 6220-6390 6480-6573 HEPAP34 2509 703336 AC023500 9917  1-90 204-285 394-540 757-840 1060-1090 HEPAP34 2509 703336 AC023500 9918  1-44  976-1138 1382-1480 1506-1645 2208-2505 2848-2978 3094-3276 4404-4939 5843-5881 HEPAJ14 2512 657440 AL158843 9919  1-749 HEPAJ14 2512 657440 AL158843 9920  1-548 HEPAJ04 2513 933091 AC078837 9921  1-358 HEPAJ04 2513 933091 AC015937 9922  1-295 1964-2131 2295-2696 HEPAJ04 2513 933091 AC007993 9923  1-295 1964-2131 2295-2696 HEPAJ04 2513 933091 AC015937 9924  1-152 343-406 656-852 HEPAJ04 2513 933091 AC007993 9925  1-152 343-406 656-852 HEPAE58 2514 509130 AL356017 9926  1-422 489-1010 1016-1105 4311-4768 4930-5657 12468-12775 12982-13085 17810-19506 19953-20359 20615-20935 21563-21594 21625-21685 21806-22238 HEPAE58 2514 509130 AL117187 9927  1-422  489-1009 1015-1104 4310-4767 4929-5656 12467-12774 12981-13084 17809-19505 19952-20358 20614-20934 21562-21593 21624-21684 21805-22237 HEPAE02 2515 921389 AC004887 9928  1-573 HEGBA01 2518 915596 AC006333 9929  1-164 HEGBA01 2518 915596 AC006333 9930   1-1132 HEGBA01 2518 915596 AC006333 9931  1-106 HEGAQ91 2520 789940 AL031319 9932  1-429 1170-1866 7200-7527 8540-8925 HEGAL55 2521 731654 AL133367 9933  1-51  740-1103 3374-3642 5341-6839 HEGAL55 2521 731654 AL139300 9934  1-51  740-1103 3374-3642 5340-6838 HEGAL55 2521 731654 AL133367 9935  1-680 HEGAL55 2521 731654 AL139300 9936  1-535 HEGAL55 2521 731654 AL139300 9937  1-680 HEGAJ08 2522 959216 AC013472 9938  1-162 207-664 1217-1396 1663-1842 2264-3540 3892-4029 HEGAC02 2523 918992 Z93016 9939  1-154 1660-2193 4376-4518 4613-4754 5136-5690 HEGAC02 2523 918992 Z93016 9940  1-196 HEEAY84 2524 782706 AC058792 9941  1-366  744-1196 HEEAY84 2524 782706 AC024408 9942  1-366  744-1196 HEEAY84 2524 782706 AL162578 9943  1-366  744-1196 HEEAY84 2524 782706 AL136091 9944  1-366  744-1196 HEEAY84 2524 782706 AC024408 9945  1-379 HEEAY84 2524 782706 AL162578 9946  1-379 HEEAY84 2524 782706 AL136091 9947  1-379 HEEAY84 2524 782706 AC058792 9948  1-379 HEEAX09 2525 912065 AL355987 9949  1-380  897-1234 1680-1754 2724-3894 HEEAX09 2525 912065 AL355987 9950  1-412 HEEAW40 2526 710655 AL132982 9951  1-475  741-1367 HEEAP59 2527 738892 AC019120 9952  1-689  915-1330 HEEAP59 2527 738892 AC019120 9953  1-520 HEEAH94 2529 794257 AC044789 9954  1-596 HEEAH94 2529 794257 AC009877 9955  1-621 HEEAH94 2529 794257 AC039056 9956  1-618 HEEAH94 2529 794257 AC009877 9957  1-185 HEEAH94 2529 794257 AC009877 9958  1-358 HEEAH94 2529 794257 AC039056 9959  1-358 HEEAH94 2529 794257 AC039056 9960  1-185 HEEAH76 2530 769950 AC010600 9961  1-835 1917-2695 HEEAH76 2530 769950 AC010600 9962  1-527 HEEAH76 2530 769950 AC010600 9963  1-516 HEEAH57 2531 734488 AC069029 9964  1-561  661-1152 HEEAH57 2531 734488 AC069029 9965  1-150 HEEAG51 2533 930810 U73637 9966  1-456  624-1143 1468-3366 5719-5910 11252-11421 16310-16521 16547-16574 18633-20907 HEEAG51 2533 930810 AF015416 9967  1-456  677-1130 1469-3367 5720-5912 6136-6235 11254-11423 16312-16523 16549-16576 18636-19929 HEEAG51 2533 930810 AF015416 9968  1-727 HEEAG51 2533 930810 U73637 9969  1-280 HEEAG51 2533 930810 AF015416 9970  1-280 HEEAD13 2535 470886 AC020558 9971  1-162 5477-5629 8588-8704 8974-9372  9931-10402 11053-11250 11813-11910 12288-12575 HEEAD13 2535 470886 AC073621 9972  1-153 3113-3228 3498-3896 4455-4926 5578-5775 6338-6435 6813-7100 10158-10763 11954-11987 HEEAD13 2535 470886 AC073621 9973  1-428 HEAAX26 2537 684734 AL159994 9974   1-2470 HEAAX26 2537 684734 AL159994 9975  1-313 HEAAR47 2539 973284 AC004672 9976  1-735 HEAAR21 2540 883939 AC005146 9977  1-979 HEAAR21 2540 883939 AC005146 9978  1-331 HEAAR21 2540 883939 AC005146 9979  1-396 HEAAN43 2541 842032 AC008435 9980  1-342 1365-2096 HEAAG42 2545 714041 AC015531 9981  1-1301 HEAAG42 2545 714041 AC015531 9982  1-569 HEAAG42 2545 714041 AC015531 9983  1-102 HEAAB66 2546 844361 AC002404 9984  1-732 3584-3740 HEAAB66 2546 844361 AC002404 9985  1-175 HEAAIB66 2546 844361 AC002404 9986  1-343 HCOPI07 2549 651645 AC015589 9987  1-501 HCOPI07 2549 651645 AC010328 9988  1-501 HCOPI07 2549 651645 AC015589 9989  1-452 HCOPI07 2549 651645 AC015589 9990  1-309 HCOPI07 2549 651645 AC010328 9991  1-309 HCOPI07 2549 651645 AC010328 9992  1-452 HCOPF07 2550 951655 AL139142 9993  1-687  714-1246 HCOPF07 2550 951655 AC021635 9994  1-687  714-1246 HCOOF07 2551 951693 AC000016 9995   1-2256 HCOOF07 2551 951693 AC025090 9996  1-61  388-1387 4757-5078 5239-5403 5784-6271 6305-9404 HCOOF07 2551 951693 AC000016 9997   1-2086 HCOOF07 2551 951693 AC025090 9998  1-426 HCOOF07 2551 951693 AC000016 9999  1-797 HCOOF07 2551 951693 AC025090 10000   1-2087 HCONP02 2552 917577 AC022441 10001   1-1525 1644-2207 HCONP02 2552 917577 AC008811 10002   1-1268 1387-1950 HCONP02 2552 917577 AC008831 10003  1-72 1850-1898 1960-2591 3025-3362 3408-3487 3859-4611 4949-5354 5927-6259 7760-8619 9073-9122 10060-10638 10766-11381 12595-12900 14574-15215 17051-17438 18105-18470 18786-19243 19413-20937 21056-21619 HCONP02 2552 917577 AC022441 10004  1-458 HCONP02 2552 917577 AC008811 10005  1-458 HCONP02 2552 917577 AC008831 10006  1-140 HCONM33 2553 971637 AF196969 10007   1-1043 1119-1879 HCONM33 2553 971637 AF196969 10008  1-483 HCONM33 2553 971637 AF196969 10009  1-266 HCHNW48 2557 962478 AL157369 10010  1-46 279-590 2838-3019 5420-5719 6799-7566 HCHNW48 2557 962478 AL157369 10011  1-441 HCHNW48 2557 962478 AL157369 10012  1-570 HCHMJ89 2560 786765 AL353760 10013  1-405 2788-2851 HCHMJ89 2560 786765 AL139410 10014  1-405 2788-2851 HCHMJ89 2560 786765 AL353760 10015  1-130 1147-1704 2371-2416 2507-3019 3056-3180 3335-3656 3695-3784 HCHMJ89 2560 786765 AL139410 10016  1-440  470-1166 1737-5349 5455-6170 6814-6950 7356-8416 10213-10336 10460-10627 10656-11870 HCHMJ89 2560 786765 AL353760 10017  1-440  470-1166 1737-5343 5455-6170 6814-6950 7356-8416 10213-10336 10460-10627 10656-11870 HCHMJ89 2560 786765 AL139410 10018  1-130 1147-1704 2373-2416 2507-3019 3056-3180 3335-3656 3695-3784 HCHMI96 2561 800129 U91323 10019  1-586 1448-1702 2440-2932 3527-3569 3822-3926 4216-4627 8710-8764 HCHMI96 2561 800129 1191323 10020  1-367 HCHMI96 2561 800129 U91323 10021  1-684 HCHCI07 2563 952957 AL031666 10022  1-956 HCHCI07 2563 952957 AL031666 10023  1-162 HCHCI07 2563 952957 AL031666 10024  1-287 HCHCG28 2565 686431 AC008720 10025   1-2147 3523-3676 3898-4059 HCHCG28 2565 686431 AC008720 10026  1-87 HCHCE78 2566 773428 AC016135 10027  1-845 HCHCE78 2566 773428 AC022305 10028  1-878 HCHCE78 2566 773428 AC018512 10029  1-776 HCHCE78 2566 773428 AC002518 10030  1-150 HCHBQ27 2567 682308 AC022466 10031  1-191 HCHBQ27 2567 682308 AC016135 10032  1-845 HCHBQ27 2567 682308 AC022305 10033  1-878 HCHBQ27 2567 682308 AC018512 10034  1-776 HCHBQ27 2567 682308 AC069145 10035  1-302 HCHBQ27 2567 682308 AC002518 10036  1-150 HCHBQ27 2567 682308 AC022466 10037  1-358 HCHBQ27 2567 682308 AC069145 10038  1-75 HCHBN09 2568 625420 AC023572 10039   1-1010 HCHBN09 2568 625420 AC011630 10040  1-680 HCHBN09 2568 625420 AC013557 10041  1-743 15203-20746 HCHBN09 2568 625420 AL158197 10042   1-1678 HCHBN09 2568 625420 AC010554 10043   1-1242 1316-3871 4275-5565 6216-6811 7004-7388 7749-8799  9220-10381 10766-12026 12271-13076 HCHBN09 2568 625420 AC013557 10044  1-123 HCHBN09 2568 625420 AL158197 10045  1-260 HCHBN09 2568 625420 AC013557 10046  1-355 HCHBN09 2568 625420 AC010554 10047  1-368 HCHAG52 2572 726081 AC015679 10048  1-405 HCHAG52 2572 726081 AC015679 10049  1-222 HCHAG52 2572 726081 AC015679 10050  1-103 HCDMF96 2573 796196 AC004676 10051  1-80 563-871 1053-1408 1467-2070 4385-4481 4889-4977 5408-5903 6173-6232 6875-7016  9420-10150 11107-11627 HCDMF96 2573 796196 AC004676 10052  1-126 HCDMF96 2573 796196 AC004676 10053  1-323 HCDMC86 2575 785134 AC007337 10054  1-74  578-1317 HCDMC86 2575 785134 AC009039 10055  1-74  579-1318 HCDMC86 2575 785134 AC007337 10056  1-278 HCDMC86 2575 785134 AC009039 10057  1-278 HCDMC22 2578 672815 AC012204 10058  1-74 HCDMB91 2580 789551 AL358472 10059  1-348 HCDMB42 2581 713300 AC024971 10060  1-274 HCDMB42 2581 713300 AL078591 10061  1-283 HCDMB41 2582 711996 AC024481 10062  1-588 HCDMB27 2583 682389 AC027783 10063  1-298 HCDMB27 2583 682389 AC027576 10064  1-298 HCDMB03 2586 923316 AL030997 10065  1-325 HCDMB03 2586 923316 AL030997 10066  1-340 HCDMB03 2586 923316 AL030997 10067  1-268 HCDMA20 2587 669201 AC016874 10068  1-72 1460-2583 HCDMA20 2587 669201 AC016721 10069  1-72 1460-2583 HCDMA20 2587 669201 AC016874 10070  1-98 HCDMA20 2587 669201 AC016721 10071  1-454 HCDMA20 2587 669201 AC016874 10072  1-458 HCDMA20 2587 669201 AC016721 10073  1-98 HCBMZ07 2589 951788 AL049610 10074  1-888 HCBMZ07 2589 951788 AL049610 10075  1-296 HCBMZ07 2589 951788 AL049610 10076  1-37 1329-3923 HCBMY10 2590 961718 AL158048 10077   1-1688 1805-2714 HCBMY10 2590 961718 AC041046 10078  1-908 HCBMY10 2590 961718 AC041046 10079  1-112 HCBMY10 2590 961718 AL158048 10080  1-112 HCBMY10 2590 961718 AC041046 10081  1-703 HCBMG11 2591 965394 AC013669 10082  1-181 291-782 2171-2360 2703-3570 4336-4689 5249-5785 5817-6442 6834-7458 HCBMG11 2591 965394 AC013669 10083  1-487 HBZSG02 2593 920249 AC008053 10084  1-996 HBZSG02 2593 920249 AC008053 10085  1-112 HBZSD32 2594 699335 AC011235 10086  1-354 HBZSD32 2594 699335 AC011235 10087  1-151 HBZAJ73 2595 764479 AC073594 10088  1-729 1248-1374 HBZAJ73 2595 764479 AC068986 10089  1-729 1248-1375 HBZAJ73 2595 764479 AC010892 10090  1-729 1248-1375 HBZAJ73 2595 764479 AC073594 10091  1-555 HBZAJ73 2595 764479 AC068986 10092  1-554 HBZAJ73 2595 764479 AC010892 10093  1-554 HBZAJ26 2596 681879 AC036116 10094  1-682 HBZAJ26 2596 681879 AL358976 10095  1-682 HBZAJ26 2596 681879 AC036116 10096  1-245 1588-2237 HBZAJ26 2596 681879 AL358976 10097  1-689 HBZAJ26 2596 681879 AC036116 10098  1-689 HBZAJ26 2596 681879 AL358976 10099  1-245 1588-2237 HBZAI39 2597 847621 AC009036 10100   1-1337 HBZAI39 2597 847621 AC012320 10101   1-1338 HBZAI39 2597 847621 AC009036 10102  1-126 HBZAI39 2597 847621 AC009036 10103  1-104 HBZAI14 2598 847620 AC073635 10104  1-466 HBZAI14 2598 847620 AC073635 10105  1-676 HBZAB15 2599 660348 AC019190 10106  1-894  941-2689 NBZAB15 2599 660348 AC025171 10107  1-894  941-2485 HBZAB08 2600 959560 AP002448 10108  1-235 HBZAB08 2600 959560 AP002448 10109  1-272 HBNBL29 2603 703113 AC008915 10110   1-1744 HBNBL29 2603 703113 AC008915 10111  1-420 HBNBJ29 2604 907015 AC036160 10112  1-334 HBNBJ29 2604 907015 AC016995 10113  1-334 HBNBJ29 2604 907015 AC036160 10114  1-470 HBNBJ29 2604 907015 AC036160 10115  1-99 HBNBJ29 2604 907015 AC016995 10116  1-99 HBNBJ29 2604 907015 AC016995 10117  1-470 HBNBJ06 2605 960664 AC061996 10118  1-527 HBNBJ06 2605 960664 AC022579 10119  1-173 1341-1867 4892-4933 HBNBJ06 2605 960664 AC022579 10120  1-492 HBNBB09 2608 868924 AL365223 10121  1-73 2336-3428 HBNBB09 2608 868924 AL365223 10122  1-851 HBNAW73 2609 764716 Z99289 10123   1-1491 HBNAW73 2609 764716 Z99289 10124  1-110 HBNAW73 2609 764716 Z99289 10125  1-190 1730-1923 2881-3366 4302-4465 4635-5036 6198-6347 6938-7175 7445-7543 7995-8128 12062-13446 13544-14273 HBNAC32 2614 526549 AC018648 10126  1-855 1191-1323 3823-3881 4371-5379 HBNAC32 2614 526549 AC018648 10127  1-125 180-388  891-1383 1802-1965 2065-2506 HBNAC28 2615 525832 AC007539 10128  1-728 HBNAC09 2617 525833 AL132713 10129 1-2438 HBNAC09 2617 525833 AL132713 10130  1-355 392-835 914-995 1054-1333 1586-1743 2135-2199 HBNAC09 2617 525833 AL132713 10131  1-124 HBNAC02 2618 921187 AL133523 10132  1-188 HBNAC02 2618 921187 AL133523 10133   1-1700 1768-2230 2511-2678 3146-6917 8428-8644 8873-9205 11616-11679 14711-14834 15647-16163 17626-17691 18185-18607 20796-20845 HBNAC02 2618 921187 AL133523 10134  1-113 2404-2767 2862-3319 3371-3750 3847-4180 6007-6752 8810-9371 HBGTT76 2619 903653 AC006512 10135  1-658 3090-3543 4479-5105 5885-6846 7103-9707  9914-10293 11523-12034 12067-12181 13769-14031 14199-14291 14584-14790 15123-15154 17039-17482 17539-17987 18697-19052 19112-19380 20023-20268 21158-21598 21817-22221 23565-23665 23906-24076 24981-25506 25510-25861 25981-26645 26661-27449 27717-27812 27991-28024 28437-28888 29651-33442 33621-34089 34245-34808 34819-35284 35854-35960 38525-38771 HBGTT76 2619 903653 AC006512 10136  1-315 439-531  707-1080 1144-1227 1491-1845 2113-2321 2700-3556 3818-4307 4336-4813 4958-5775 HBGTT76 2619 903653 AC006512 10137  1-738 HBGTE11 2620 965121 AF037222 10138  1-34 504-637 1210-2684 3241-3528 3799-4114 4225-4439 4754-4886 5520-6004 6811-6950 8255-8470  9691-10480 10798-11383 12144-12327 12452-12657 12889-13456 13751-13876 13921-14373 14745-15119 15895-16112 16289-16338 16453-17862 HBGTE11 2620 965121 AL049840 10139  1-34 527-678 1208-2682 3785-4100 4211-4425 5506-5990 6797-6936 8241-8456  9677-10466 10784-11369 12130-12313 12438-12643 12875-13442 13740-13862 13907-14359 14731-15105 15881-16098 16275-16324 16440-17849 HBGTE11 2620 965121 AF037222 10140  1-126 HBGTE11 2620 965121 AF037222 10141  1-941 1055-1957 HBGTE11 2620 965121 AL049840 10142  1-126 HBGTE11 2620 965121 AL049840 10143   1-1797 HBGQS88 2621 886650 AC004152 10144   1-1226 HBGNL8S 2622 848179 AL359510 10145  1-340  433-1692 HBGNL85 2622 848179 AL359510 10146  1-620 HBGND04 2623 926973 AC011686 10147  1-50 2676-3023 3161-3501 3760-4076 5867-6062 6851-7280 7581-8170 HBGND04 2623 926973 AP000560 10148   1-1137 1749-2085 4498-4845 4983-5323 5582-5898 7689-7884 8673-9102 9403-9993 HBGND04 2623 926973 AP001324 10149  1-50 2675-3022 3159-3500 3759-4075 5866-6061 6851-7280 7581-8170 HBGND04 2623 926973 AP000560 10150  1-93 HBGND04 2623 926973 AC011686 10151   1-3688 3726-3971 4813-5933 6168-6648 HBGND04 2623 926973 AP001324 10152   1-2189 HBGND04 2623 926973 AP000560 10153   1-2577 HBGMT82 2624 954374 AP000449 10154   1-1171 1258-1698 HBGMT82 2624 954374 AC055871 10155   1-1174 1258-2167 2367-2591 2949-3669 HBGMT82 2624 954374 AJ002553 10156  1-286 HBGMT82 2624 954374 AC051660 10157   1-1173 1256-2164 2364-2588 2946-3665 3840-4059 4135-4280 HBGMT82 2624 954374 AJ002553 10158  1-137 586-767 HBGMT82 2624 954374 AC051660 10159  1-473 HBGMT82 2624 954374 AC051660 10160  1-82 433-487  583-1153 1232-1412 HBGMS69 2625 754392 AC010427 10161  1-757 HBGMS69 2625 754392 AC026740 10162  1-757 HBGMS69 2625 754392 AC016498 10163  1-757 HBGMS69 2625 754392 AC010427 10164  1-424 HBGMS69 2625 754392 AC026740 10165  1-115  765-1186 HBGMS69 2625 754392 AC010427 10166  1-416 HBGMS69 2625 754392 AC016498 10167  1-424 HBGMS69 2625 754392 AC026740 10168  1-227 229-411 HBGMS69 2625 754392 AC016498 10169  1-417 HBGMO78 2626 773043 AL139220 10170  1-877 1373-1821 2802-3760 3769-4392 4968-5660 HBGMO78 2626 773043 AL357079 10171  1-878 1374-1822 2800-3758 3767-4390 4968-5660 HBGMO78 2626 773043 AC005038 10172  1-878 1374-1822 2803-3761 3770-4393 5226-5663 5775-5902 6120-6317 9252-9488  9701-10068 11666-11809 HBGMO78 2626 773043 AC005038 10173   1-1280 1472-1999 2116-3378 HBGMO78 2626 773043 AC005038 10174   1-1182 1260-1342 1447-2170 2566-3297 3550-3759 4478-4598 4690-4919 5109-5311 HBGMG81 2627 880276 AC026905 10175  1-38 HBGMG81 2627 880276 AC027551 10176  1-38 HBGMG81 2627 880276 AL365398 10177  1-47 HBGMG81 2627 880276 AC020714 10178  1-440 1153-1430 HBGMG81 2627 880276 AC006512 10179  1-247 2812-2918 3488-3953 3964-4527 4683-5151 5330-9121  9884-10335 10748-10781 10960-11055 11323-12111 12127-12791 12911-13262 13266-13791 14696-14866 15107-15207 16551-16955 17174-17614 18504-18749 19392-19660 19720-20075 20785-21233 21290-21733 23618-23649 23982-24188 24481-24573 24741-25003 26591-26705 26738-27249 28479-28858 29065-31669 31926-32887 33667-34293 35229-35682 38114-38771 HBGMG81 2627 880276 AC027551 10180  1-131 HBGMG81 2627 880276 AC020714 10181  1-842 HBGMG81 2627 880276 AC006512 10182  1-818  963-1440 1469-1958 2220-3076 3455-3663 3931-4285 4549-4632 4696-5069 5245-5337 5461-5775 HBGMG81 2627 880276 AC020714 10183   1-1160 HBGMG81 2627 880276 AC006512 10184  1-738 HBGFS88 2628 914032 AC010687 10185  1-144 1186-2261 HBGFS88 2628 914032 AC005369 10186  1-649  870-1459 2153-2236 2499-2621 2722-2856 3368-3523 4084-4227 4315-4423 4652-4777 5094-5193 5519-5647 5739-5983 6144-6260 6507-6661 7019-8042 8949-9295 9392-9485 10579-10703 11915-11969 11976-12107 12491-12570 12627-13146 14186-15261 HBGFS88 2628 914032 AC010687 10187  1-109 HBGFS88 2628 914032 AC005369 10188  1-109 HBGFS88 2628 914032 AC005369 10189  1-86 357-503 HBGFG53 2629 727748 AC026666 10190  1-791 HBGFG53 2629 727748 AC026283 10191   1-1463 HBGFG53 2629 727748 AC026666 10192  1-244 HBGFG53 2629 727748 AC026283 10193  1-319 HBGFG53 2629 727748 AC026283 10194  1-297  330-1653 HBGDA74 2632 832888 AP001100 10195  1-102 420-643 761-840 1681-1796 1917-2066 2158-2417 3079-3200 3281-3345 3436-4001 4062-4625 HBGDA74 2632 832888 AP000481 10196  1-64 188-337 429-688 1350-1471 1552-1616 1707-2271 2332-2895 HBGDA74 2632 832888 AP000481 10197  1-540 1012-1076 1166-1313 1698-1760 1787-1874 1971-2103 2575-2765 3027-3073 HBGDA74 2632 832888 AP001100 10198  1-540 1012-1076 1166-1198 HBGBG52 2635 522424 AL136458 10199  1-294 506-707 1776-2011 2535-4755 5405-5870 5873-6187 7245-7361 7501-7967 9091-9694  9825-10069 10913-11066 11815-12127 HBGBG52 2635 522424 AC069042 10200  1-245 HBGBG52 2635 522424 AL162739 10201  1-245 HBGBG52 2635 522424 AL136458 10202  1-112 HBGBG52 2635 522424 AL162739 10203  1-604 HBGBB78 2638 773930 AC008403 10204  1-1630 2058-2480 4161-4577 5334-5745 6732-6865 7024-7163 10746-11227 11908-12229 12481-13862 HBGBB78 2638 773930 AC008403 10205  1-482 2074-2191 3067-3427 3514-3666 4176-4250 4718-4839 5313-5692 10395-10491 10694-10779 11107-11256 12127-12209 12283-12405 12543-13031 13771-14040 HBGBB78 2638 773930 AC008403 10206  1-218 172-232 1302-2232 HBCPO75 2640 927520 AC069279 10207  1-596 4098-4739 5478-5650 6045-6577 6988-7374 HBCPK03 2641 922493 AC011719 10208  1-923 HBCPK03 2641 922493 AP001104 10209  1-923 HBCPK03 2641 922493 AP001324 10210  1-923 HBCJP02 2642 917981 AP000795 10211  1-935 1442-2055 2120-2651 HBCJP02 2642 917981 AC018775 10212  1-935 1442-2055 2120-2653 HBCJP02 2642 917981 AC01 1088 10213  1-254 1365-1474 2669-2833 3184-3483 3853-4390 9055-9989 10496-11109 11174-11705 14770-14905 15601-16949 24077-24508 25195-25367 27155-27556 28055-28776 29078-30192 35093-35409 37099-37222 37906-38308 39047-39871 40730-41079 41464-41939 42882-44161 HBCJP02 2642 917981 AC011088 10214  1-379 HBCJG07 2643 951898 AL158821 10215  1-179  415-1143 HBCJG07 2643 951898 AL158821 10216  1-401 691-974 1279-2180 HAUCC58 2644 764851 AC006329 10217  1-159 388-562  976-1372 1647-1772 1796-2110 2230-2442 3917-4291 4695-4807 4854-4990 5212-5512 6837-7180 7293-7754 8183-8372 8413-8665 9645-9815 10677-11353 11786-12287 12400-13026 HAUCC58 2644 764851 AC006329 10218  1-338 1214-1745 HAUAS89 2646 518847 AC008044 10219  1-119 2461-2803 4346-4547 5141-5577 7669-7807 7933-8244 8849-8944  9208-10426 12618-12735 13747-14129 14744-15306 HAUAS89 2646 518847 AC008044 10220  1-55 3400-3593 HAUAS89 2646 518847 AC008044 10221  1-495 HAUAQ28 2647 685374 AC027523 10222   1-1260 HAUAQ28 2647 685374 AC011774 10223   1-1260 HAUAQ28 2647 685374 AP001848 10224   1-1260 HAUAQ28 2647 685374 AC027523 10225  1-535 HAUAQ28 2647 685374 AC011774 10226  1-535 HAUAQ28 2647 685374 AP001848 10227  1-535 HACMR08 2650 955638 AC012318 10228  1-147 HACMR08 2650 955638 AL121844 10229  1-216 HACMR08 2650 955638 AC013553 10230  1-280 2514-2880 3507-3803 5834-5958 8010-8114 9356-9430 13100-13296 14272-14676 14966-15305 15968-16340 16952-17049 17302-17464 18685-19018 19824-20193 20412-20822 21304-21778 22964-23210 23327-23714 24031-24645 24690-24771 26370-27118 HACMR08 2650 955638 AL121656 10231   1-2346 2487-3703 3832-4167

[0087] Table 1B summarizes additional polynucleotides encompassed by the invention (including cDNA clones related to the sequences (Clone ID NO: Z), contig sequences (contig identifier (Contig ID:) contig nucleotide sequence identifiers (SEQ ID NO: X)), and genomic sequences (SEQ ID NO: B). The first column provides a unique clone identifier, “Clone ID NO: Z”, for a cDNA clone related to each contig sequence. The second column provides the sequence identifier, “SEQ ID NO: X”, for each contig sequence. The third column provides a unique contig identifier, “Contig ID:” for each contig sequence. The fourth column, provides a BAC identifier “BAC ID NO: A” for the BAC clone referenced in the corresponding row of the table. The fifth column provides the nucleotide sequence identifier, “SEQ ID NO: B” for a fragment of the BAC clone identified in column four of the corresponding row of the table. The sixth column, “Exon From-To”, provides the location (i.e., nucleotide position numbers) within the polynucleotide sequence of SEQ ID NO: B which delineate certain polynucleotides of the invention that are also exemplary members of polynucleotide sequences that encode polypeptides of the invention (e.g., polypeptides containing amino acid sequences encoded by the polynucleotide sequences delineated in column six, and fragments and variants thereof). TABLE 2 SEQ Score/ Clone ID Contig ID Analysis PFam/NR Accession Percent NT NT NO:Z ID: NO:X Method PFam/NR Description Number Identity From To H7MDD72 847688 13 blastx.2 (AF034780) gb|AAC98919.1| 95% 597 7 lysosphingolipid receptor Edg5 [Homo sapiens] H7MDD72 887805 2651 HMMER PFAM: 7 transmembrane PF00001 118 75 668 1.8 receptor (rhodopsin family) HAOSH55 952380 14 blastx.2 (AF200357) pantothenate gb|AAF23952.1|AF2 78% 2 337 kinase 1 beta [Mus 00357_1 musculus] HAQAK73 764671 15 blastx.2 galactosylceramide-like pir|JC5238|JC5238 65% 129 7 protein, GCP - human HAQBJ71 839982 18 blastx.2 BasR [Escherichia coli] dbj|BAA03143.1| 97% 127 2 51% 392 123 HBCJS08 957826 23 blastx.2 (AK002129) unnamed dbj|BAA92096.1| 66% 188 346 protein product [Homo sapiens] HBGBG42 922396 30 blastx.2 (AF161472) HSPC123 gb|AAF29087.1|AF1 50% 85 315 [Homo sapiens] 61472_1 HBGBT79 525352 33 blastx.2 Invasin. [Escherichia coli] dbj|BAA15799.1| 58% 35 331 49% 3 209 87% 199 246 HBGBW60 954916 34 blastx.2 paired-like homeodomain gb|AAB39864.1| 100% 101 235 protein PRX2 [Homo sapiens] HBGDE85 524875 37 blastx.2 core protein [Escherichia gb|AAA24544.1| 90% 1 126 coli] HBGDS13 971696 38 HMMER PFAM: Zinc finger, C2H2 PF00096 4.57 167 211 1.8 type blastx.2 rhaR (AA 1-312) emb|CAA29453.1| 86% 257 129 [Escherichia coli] 92% 141 100 HBGDT43 974223 39 blastx.2 (AK000496) unnamed dbj|BAA91205.1| 80% 445 311 protein product [Homo sapiens] HBGMD05 870189 41 blastx.2 Fos-related antigen gb|AAA79137.1| 88% 4 207 [Rattus norvegicus] HBGMZ39 947112 45 HMMER PFAM: Cytochrome P450 PF00067 59.5 509 372 2.1.1 blastx.2 cytochrome P450 2B - pir|JT0676|JT0676 43% 563 372 green monkey 43% 299 168 40% 165 121 HBGND09 848219 47 blastx.2 (AF156271) RING finger gb|AAD40286.1| 97% 2 367 protein terf [Homo sapiens] HBGNM13 912730 49 blastx.2 (AE000420) putative gb|AAC76465.1| 97% 188 75 regulator [Escherichia coli] HBGN007 952212 50 blastx.2 (AK000496) unnamed dbj|BAA91205.1| 81% 383 323 protein product [Homo 33% 169 53 sapiens] HBGNQ31 887152 51 blastx.2 (AF022821) putative gb|AAD09338.1| 56% 10 183 potassium channel DP4 [Mus musculus] HBGPH02 918513 58 blastx.2 alpha 1C adrenergic dbj|BAA06901.1| 71% 452 327 receptor isoform 2 [Homo 93% 339 292 sapiens] 69% 292 254 HBGPV05 930706 60 blastx.2 (AE000157) orf, gb|AAC73617.1| 77% 617 36 hypothetical protein 47% 555 346 [Eseherichia coli] 76% 619 545 HBGTR84 886529 65 blastx.2 (AL137718) hypothetical emb|CAB70890.1| 30% 21 581 protein [Homo sapiens] HBNAY58 558193 72 blastx.2 human elongation factor- emb|CAA79716.1| 73% 263 400 1-delta [Homo sapiens] HCBNW02 950897 80 blastx.2 (AC008372) unknown gb|AAF23326.1|AC0 44% 1 270 [Homo sapiens] 08372_2 HCBOG03 922351 82 HMMER PFAM: Zinc finger, PF00098 6.1 95 112 1.8 CCHC class HCHAD40 923764 88 blastx.2 unidentified reading frame emb|CAA23893.1| 85% 211 152 [Escherichia coli] 87% 311 264 100% 264 226 87% 325 302 HCHBQ03 923763 92 blastx.2 unidentified reading frame emb|CAA23893.1| 98% 334 158 [Escherichia coli] HCHND96 880585 94 blastx.2 (AF141920) roadblock gb|AAD45986.1|AF1 75% 174 455 [Drosophila melanogaster] 41920_1 HCHOA76 740102 95 blastx.2 (AK000385) unnamed dbj|BAA91131.1| 64% 499 335 protein product [Homo 75% 266 195 sapiens] 58% 336 286 HCHOD89 954866 96 blastx.2 cytochrome P450 2C34v2 gb|AAA79105.1| 53% 94 189 [Sus scrofa] 33% 6 86 HCHQB06 934941 98 blastx.2 (AK001623) unnamed dbj|BAA91793.1| 89% 183 440 protein product [Homo sapiens] HCOOZ11 965306 105 HMMER PFAM: Src homology PF00018 5.22 179 214 1.8 domain 3 blastx.2 (AL022238) dJ1042K10.2 emb|CAA18266.1| 100% 182 589 (supported by GENSCAN, FGENES and GENEWISE) [Homo sapiens] HEAAA42 963100 111 HMMER PFAM: Zinc finger, C2H2 PF00096 20.88 114 176 1.8 type blastx.2 (AF117814) odd-skipped gb|AAD37115.1|AF1 79% 18 221 related 1 protein [Mus 17814_1 musculus] HEEAH07 851219 124 blastx.2 (AL137469) hypothetical emb|CAB70754.1| 100% 178 270 protein [Homo sapiens] HEEAJ58 785121 125 blastx.2 (AF080470) pallid [Homo gb|AAF08343.1|AF0 100% 169 258 sapiens] 80470_1 100% 90 170 66% 169 252 HEEAJ76 887321 126 blastx.2 truncated protein gb|AAB31222.1| 87% 94 23 [Saccharomyces cerevisiae] HEEAW01 851213 133 blastx.2 (AK000385) unnamed dbj|BAA91131.1| 72% 371 210 protein product [Homo sapiens] HEGAB84 823900 137 HMMER PFAM: Ank repeat PF00023 36.9 205 315 2.1.1 blastx.2 ankyrin 3 [Mus musculus] gb|AAB01605.1| 37% 28 348 HEGAI82 955291 140 blastx.2 putative [Rattus emb|CAA52297.1| 58% 1 276 norvegicus] 96% 370 453 31% 179 283 HEGAO83 780837 142 HMMER PFAM: IG PF00047 9.4 234 305 1.8 (immunoglobulin) superfamily HEGAZ61 950033 149 HMMER PFAM: Reprolysin family PF01562 141.4 276 560 2.1.1 propeptide blastx.2 epididymal apical protein emb|CAA46929.1| 92% 60 560 I-precursor [Macaca fascicularis] HEPAB70 557149 151 blastx.2 ORF_ID:o209#7 dbj|BAA35540.1| 83% 99 329 [Escherichia coli] 87% 43 141 90% 326 355 HEPAP02 926914 160 blastx.2 WW domain binding gb|AAD10950.1| 100% 59 163 protein-1 [Homo sapiens] HEPBA39 919875 163 HMMER PFAM: lipocalins PF00061 26.73 117 509 1.8 blastx.2 (AF109472) epididymal gb|AAC98311.1| 42% 314 66 protein 52 [Oryctolagus cuniculus] HEPBH38 707524 169 blastx.2 (AK000385) unnamed dbj|BAA91131.1| 53% 319 146 protein product [Homo sapiens] HEPCT32 947081 179 blastx.2 (AJ243311) matrix emb|CAB46656.1| 32% 262 636 metalloproteinase-2 39% 262 477 [Equus caballus] 32% 24 269 27% 18 275 HEPCU32 931824 180 HMMER PFAM: lipocalins PF00061 11.52 508 627 1.8 blastx.14 mE-RABP minor form gi|3241966|gb|AAC2 30% 502 630 protein [Mus musculus] 4316.1| 20% 336 482 60% 279 308 HEPCU32 946975 2652 HMMER PFAM: lipocalins PF00061 11.52 405 524 1.8 blastx.14 mE-RABP minor form gi|3241966|gb|AAC2 30% 399 527 protein [Mus musculus] 4316.1| 20% 233 379 60% 176 205 HEQAE65 911438 181 HMMER PFAM: Myosin head PF00063 35.1 50 148 2.1.1 (motor domain) blastx.2 (AF234532) myosin X gb|AAF37875.1|AF2 100% 2 154 [Homo sapiens] 34532_1 HEQAH70 699690 182 blastx.2 (AJ007558) nucleoporin emb|CAA07553.1| 85% 176 343 155 [Homo sapiens] 97% 49 171 65% 288 347 HEQAO76 769973 183 blastx.2 (AF053944) aortic gb|AAC25585.1| 100% 148 201 carboxypeptidase-like 100% 1 45 protein ACLP [Homo 34% 266 430 sapiens] 34% 269 400 31% 329 433 36% 311 424 24% 266 415 57% 390 431 35% 314 418 HETAF89 509300 189 blastx.2 (AF209069) hypothetical gb|AAF16744.1|AF2 98% 72 248 protein [Homo sapiens] 09069_2 HETAH66 799665 191 blastx.2 IgE-binding factor [Mus gb|AAA37291.1| 57% 109 216 musculus] 37% 20 115 HETAZ13 536192 201 HMMER PFAM: Src homology PF00018 3.73 165 245 1.8 domain 3 HETDI03 925489 217 blastx.2 zinc finger protein gb|AAC50260.1| 78% 18 131 ZNF133 [Homo sapiens] 70% 15 134 74% 15 131 66% 18 143 73% 18 131 60% 18 146 71% 18 131 62% 18 146 64% 18 134 65% 18 140 HETDP21 525407 220 HMMER PFAM: Zinc finger, PF00097 9.69 233 292 1.8 C3HC4 type (RING finger) blastx.2 (AF034745) LNXp80 gb|AAC40075.1| 92% 218 292 [Mus musculus] 61% 112 216 HETFC82 799658 227 HMMER PFAM: Bacterial mutT PF00293 3.03 418 480 1.8 protein blastx.2 (AL035291) hypothetical emb|CAA22894.1| 94% 7 531 protein [Homo sapiens] HETFI24 954104 230 HMMER PFAM: Spectrin alpha PF00435 9.64 628 690 1.8 chain, repeated domain blastx.2 myosin II heavy chain gb|AAB01786.1| 25% 355 1146 [Naegleria fowleri] 20% 204 434 HETFM43 973702 233 blastx.2 (AK002129) unnamed dbj|BAA92096.1| 80% 200 262 protein product [Homo 53% 303 347 sapiens] 88% 268 294 HETGL74 947978 237 HMMER PFAM: IG PF00047 15.57 213 392 1.8 (immunoglobulin) superfamily blastx.2 FOLLISTATIN-LIKE 2 sp|Q61581|Q61581 36% 132 440 (FOLLISTATIN-LIKE PROTEIN). HETHO63 745503 244 blastx.2 rhophilin [Mus musculus] gb|AAC52388.1| 51% 160 450 35% 47 157 HETHR24 851412 246 HMMER PFAM: Fibrillar collagen PF01410 53.4 201 308 2.1.1 C-terminal domain blastx.2 type V collagen [Gallus gb|AAB41274.1| 65% 213 308 gallus] 48% 86 214 41% 336 437 HETIF01 966185 248 blastx.2 fused-ccdB [Escherichia emb|CAA71575.1| 94% 122 223 coli] HETIJ84 766589 250 blastx.2 (AF161432) HSPC314 gb|AAF28992.1|AF1 75% 1 246 [Homo sapiens] 61432_1 HETJX04 927120 262 HMMER PFAM: C2 domain PF00168 150.4 9 260 2.1.1 blastx.2 (AB025258) granuphilin-a dbj|BAA84656.1| 94% 6 683 [Mus musculus] 57% 685 831 48% 719 859 HETJY11 966194 263 blastx.2 (AK000496) unnamed dbj|BAA91205.1| 70% 3 227 protein product [Homo sapiens] HETKV26 910030 270 HMMER PFAM: Oxysterol-binding PF01237 67 2 364 2.1.1 protein HETKZ65 941045 272 blastx.14 (AF067972) DNA gi|4927370|gb|AAD3 84% 63 500 cytosine methyltransferase 3084.1|AF067972_1 72% 455 520 3 alpha [Homo sapiens] 100% 520 537 HLWAH41 944774 283 HMMER PFAM: ENV polyprotein PF00429 150 82 714 2.1.1 (coat polyprotein) blastx.2 (AF108843) env protein gb|AAD34324.1| 50% 67 711 [Homo sapiens] HLWAI13 920690 284 blastx.14 (AL117538) hypothetical gi|5912069|emb|CAB 100% 496 588 protein [Homo sapiens] 55984.1| HLWAJ64 746460 285 HMMER PFAM: Zinc finger, PF00098 6.51 357 337 1.8 CCHC class HLWAK69 694216 286 HMMER PFAM: Zinc finger, C2H2 PF00096 6.05 118 168 1.8 type HLWAR77 947484 288 HMMER PRAM: 7 transmembrane PF00001 214.2 1287 553 1.8 receptor (rhodopsin family) blastx.2 (AF119815) G-protein- gb|AAD22047.1| 99% 1287 292 coupled receptor [Homo sapiens] HLWBQ84 782938 299 HMMER PFAM: HMG (high PF00505 9.46 21 110 1.8 mobility group) box HLWFG82 929647 317 HMMER PFAM: Immunoglobulin PF00047 32.6 121 330 2.1.1 domain blastx.2 Frazzled [Drosophila gb|AAC47314.1| 37% 52 411 melanogaster] 43% 488 535 HNOAX12 969363 330 blastx.2 line-1 reverse gb|AAC51337.1| 41% 710 465 transcriptase [Homo sapiens] HODAG37 529410 339 blastx.2 (AC004416) gb|AAC06181.1| 54% 229 131 WUGSC:H_RG013N12.g 58% 137 87 w.1335199.a gene product [Homo sapiens] HODBT58 678444 355 blastx.2 (AF118086) PR01992 gb|AAF22030.1|AF1 69% 1 129 [Homo sapiens] 18094_25 HODCV09 973487 375 blastx.2 (AF034209) RIG-like 5-6 gb|AAB92665.1| 100% 130 207 [Homo sapiens] HODDQ21 919295 392 blastx.2 (AF161393) HSPC275 gb|AAF28953.1|AF1 96% 3 245 [Homo sapiens] 61393_1 HODDS67 567197 394 blastx.2 (AK001614) unnamed dbj|BAA91790.1| 100% 69 164 protein product [Homo 100% 14 67 sapiens] HODER91 789661 419 HMMER PFAM: Zinc finger, C2H2 PF00096 11.06 163 225 1.8 type blastx.2 (AC007059) Human gb|AAD19818.1| 35% 1 294 homolog of Mus musculus wizL protein [AA 4-1561] [Homo sapiens] HODEX10 926260 423 HMMER PFAM: Helicases PF00271 9.2 22 54 1.8 conserved C-terminal domain HODFQ06 934304 451 blastx.2 (AK000496) unnamed dbj|BAA91205.1| 48% 466 254 protein product [Homo 60% 537 454 sapiens] HODFY16 958329 459 HMMER PFAM: Phorbol esters/ PF00130 3.15 175 213 1.8 diacylglycerol binding domain HODGC61 973449 463 HMMER PFAM: Protein-tyrosine PF00102 6.61 130 222 1.8 phosphatase HODGH02 917969 465 blastx.2 IDN4-GGTR14 sp|Q9Y6Y5|Q9Y6Y5 94% 17 118 PROTEIN. HODGH04 926255 466 blastx.2 IDN4-GGTR14 sp|Q9Y6Y5|Q9Y6Y5 51% 8 247 PROTEIN. HODGJ67 974297 471 blastx.14 pol gene protein; Xxx gi|1196424|gb|AAA8 70% 132 284 [Homo sapiens] 8026.1| HODGP95 908650 477 HMMER PFAM: Zinc finger, C2H2 PF00096 18.49 209 271 1.8 type blastx.2 (AC005498) R31665_1 gb|AAC32422.1| 61% 125 310 [Homo sapiens] 52% 146 310 53% 146 292 41% 125 310 34% 74 334 50% 146 307 51% 164 310 46% 164 310 47% 307 357 47% 307 357 47% 307 357 50% 310 357 35% 307 357 41% 307 357 HODGQ22 974290 479 blastx.2 hypothetical protein pir|S72489|S72489 47% 235 2 Tigger 2 - human 57% 287 231 transposon MER37 1 HODGQ92 894368 481 HMMER PFAM: RhoGAP domain PF00620 30.1 2 124 2.1.1 blastx.2 (AC002398) F25965_3 gb|AAB81198.1| 63% 142 399 [Homo sapiens] 72% 2 133 HOFAD05 932211 507 blastx.14 unknown [murine gi|2318003|gb|AAB6 39% 263 180 herpesvirus 68] 6461.1| 45% 192 127 85% 120 100 HOFMB78 572941 512 HMMER PFAM: Laminin B PF00052 1.62 286 330 1.8 (Domain IV) blastx.2 ribosomal protein L7a gb|AAA60282.1| 72% 49 399 large subunit [Homo 61% 236 397 sapiens] 50% 44 91 HOFMF03 924679 516 blastx.2 U88 [Human herpesvirus emb|CAA58337.1| 54% 298 116 6] 49% 298 116 50% 295 116 51% 295 116 54% 298 116 50% 295 116 51% 289 116 55% 298 116 48% 295 116 46% 295 116 52% 298 116 48% 289 116 43% 295 116 51% 295 116 49% 298 116 45% 295 116 43% 295 116 46% 295 116 45% 295 116 54% 297 115 43% 295 116 43% 295 116 45% 295 116 46% 295 116 44% 289 116 44% 289 116 43% 295 116 44% 289 116 46% 289 116 43% 295 116 43% 295 116 48% 289 116 43% 289 116 41% 295 116 44% 342 115 41% 339 115 42% 297 115 HOFMF70 734917 517 HMMER PFAM: Connexin PF00029 20.4 244 288 2.1.1 blastx.2 (AJ004856) connexin31 emb|CAA06165.1| 85% 113 259 [Homo sapiens] 70% 285 386 HOFMG21 973358 518 HMMER PFAM: MAS20 protein PF02064 33.6 105 248 2.1.1 import receptor blastx.14 mitochondrial outer gi|285987|dbj|BAA02 98% 114 416 membrane protein 19 804.1| 72% 452 484 [Homo sapiens] HOFMH12 964722 519 blastx.2 19 kDa subunit of emb|CAA42218.1| 66% 83 457 NADH:ubiquinone 64% 312 476 oxidoreductase complex (complex I) [Bos taurus] HOFMH38 920365 520 HMMER PFAM: TCP-1/cpn60 PF00118 104.8 102 287 2.1.1 chaperonin family blastx.2 unnamed protein product emb|CAA02863.1| 93% 60 296 [unidentified] 88% 326 403 100% 19 69 100% 286 327 HOFMI62 796358 523 blastx.2 (AJ388527) Ribosomal emb|CAB46829.1| 96% 40 228 protein [Canis familiaris] 96% 231 323 66% 320 355 38% 35 88 HOFMJ44 719663 525 HMMER PFAM: Ribosomal protein PF01667 109.1 128 265 2.1.1 S27 blastx.2 (AF070668) 40S gb|AAD20974.1| 95% 56 274 ribosomal protein S27 isoform [Homo sapiens] HOFMM72 464015 528 blastx.2 (AL117557) hypothetical emb|CAB55992.1| 65% 61 366 protein [Homo sapiens] HOFMP79 775242 531 HMMER PFAM: GrpE PF01025 49.4 173 358 2.1.1 blastx.2 mt-GrpE#1 precursor gb|AAC53534.1| 73% 173 400 [Rattus norvegicus] 86% 36 164 HOFMQ65 789347 534 blastx.2 (AL050369) hypothetical emb|CAB43677.1| 68% 113 343 protein [Homo sapiens] 100% 43 147 64% 354 404 HOFMS89 575820 537 blastx.2 (AF161359) HSPC096 gb|AAF28919.1|AF1 53% 181 411 [Homo sapiens] 61359_1 46% 71 277 69% 411 488 72% 48 80 HOFMT43 811542 539 blastx.2 glucosephosphate emb|CAA82246.1| 50% 143 514 isomerase [Sus scrofa] 80% 57 161 40% 277 501 HOFMT72 563575 541 blastx.2 Huntington Disease (HD) emb|CAA92991.1| 82% 52 2 gene exon 1 [Homo 50% 297 256 sapiens] HOFMU63 744325 543 blastx.2 (AK000334) unnamed dbj|BAA91091.1| 63% 9 245 protein product [Homo sapiens] HOFNA92 792734 547 blastx.2 (AL109701) C15orf3 emb|CAB52022.1| 60% 151 339 [Homo sapiens] 86% 60 125 37% 128 301 33% 128 334 HOFNG06 935569 556 blastx.2 (AL133584) hypothetical emb|CAB63728.1| 90% 80 241 protein [Homo sapiens] 90% 66 95 100% 253 270 HOFNI08 974435 558 blastx.2 (AJ224442) emb|CAA11944.1| 81% 25 423 methyltransferase [Homo sapiens] HOFNL18 666498 561 HMMER PFAM: Bacterial mutT PF00293 4.34 286 345 1.8 protein HOFNL25 916963 562 HMMER PFAM: Ribosomal L18ae PF01775 250.8 62 331 2.1.1 protein family blastx.2 ribosomal protein L18a - pir|S03957|R5RT18 73% 47 514 rat HOFNL37 906250 563 blastx.2 vimentin [Mus musculus] dbj|BAA19834.1| 51% 204 377 41% 175 396 100% 140 178 HOFNT59 615305 567 blastx.2 (AB026125) ART-4 dbj|BAA86961.1| 59% 146 451 [Homo sapiens] 42% 18 479 HOFNU72 705435 568 blastx.2 (AF086708) 26S gb|AAC64104.1| 94% 46 204 proteasome subunit 11 95% 200 259 [Homo sapiens] 81% 261 308 HOFNW79 973351 570 blastx.2 (AJ388527) Ribosomal emb|CAB46829.1| 96% 85 273 protein [Canis familiaris] 100% 276 362 84% 365 403 38% 80 133 HOFNY50 715312 572 blastx.2 (AF047704) tuftelin [Mus gb|AAC04577.1| 92% 224 388 musculus] 81% 127 222 68% 69 143 90% 393 425 58% 427 477 HOFOB88 751692 579 blastx.2 (AF139185) myomegalin gb|AAD29427.1| 80% 13 369 [Rattus norvegicus] HOFOB91 827631 580 blastx.2 nucleobindin [Homo gb|AAA36383.1| 86% 87 233 sapiens] 85% 23 43 HOFOF57 666909 582 blastx.2 T28D6.9 [Caenorhabditis emb|CAB54316.1| 43% 141 347 elegans] 57% 347 388 HOGAF39 947431 584 blastx.14 cyclin A/CDK2- gi|995826|gb|AAC50 47% 78 179 associated p45 [Homo 242.1| 45% 2 73 sapiens] 42% 216 257 HOGCX95 890607 591 HMMER PFAM: Retroviral aspartyl PF00077 32.8 205 504 1.8 proteases HOGEE76 968956 592 blastx.14 No definition line found gi|1397275|gb|AAB0 36% 650 790 [Caenorhabditis elegans] 3138.1| 60% 599 643 27% 500 586 HOVBY34 706816 602 blastx.2 (AK002129) unnamed dbj|BAA92096.1| 80% 177 40 protein product [Homo sapiens] HOVCD39 705406 605 blastx.2 (AF118081) PRO1900 gb|AAF22025.1|AF1 70% 20 151 [Homo sapiens] 18094_20 HOVEK70 909138 615 HMMER PFAM: Zinc finger, C2H2 PF00096 68.7 225 293 2.1.1 type blastx.2 Bowel [Drosophila gb|AAB17949.1| 88% 93 377 melanogaster] 35% 111 431 34% 132 377 85% 2 82 32% 81 209 33% 368 457 HPDOT03 922481 635 blastx.14 (AF061346) Edp1 protein gi|3114713|gb|AAC7 61% 212 382 [Mus musculus] 8826.1| HPDPJ69 966158 637 blastx.14 envelope protein [Homo gi|1196425|gb|AAA8 53% 92 226 sapiens] 8027.1| 62% 13 108 HPDRG92 967704 643 blastx.14 2-oxoglutarate gi|531241|dbj|BAA01 82% 7 234 dehydrogenase precursor 393.1| 73% 237 326 [Homo sapiens] 35% 1 60 75% 279 302 HPEKG18 914115 656 blastx.14 (AB012223) ORF2 [Canis gi|2981631|dbj|BAA2 75% 96 10 familiaris] 5253.1| HPFEA08 960372 700 HMMER PFAM: HMG (high PF00505 5.1 68 148 1.8 mobility group) box HPIAS40 928614 708 blastx.14 (AF044954) gi|4164442|gb|AAD0 96% 68 232 NADH:ubiquinone 5419.1| 88% 304 384 oxidoreductase PDSW 92% 262 303 subunit [Homo sapiens] 53% 384 461 HPIAX11 925424 710 blastx.2 (AL031427) dJ167A19.1 emb|CAB46721.1| 63% 342 569 (novel protein) [Homo 78% 449 604 sapiens] HPIAZ37 655753 711 HMMER PFAM: ATP synthase A PF00119 11.95 68 238 1.8 chain HPIBQ37 884289 712 HMMER PFAM: Immunoglobulin PF00047 42 149 355 2.1.1 domain blastx (AF111713) junctional gb|AAD42050.1|AF1 100% 89 385 adhesion molecule [Homo 11713_1 84% 385 423 sapiens] HPJCC04 926787 731 blastx.14 (AF159714) PPAR gi|5802182|gb|AAD5 94% 249 40 gamma coactivator-1 1615.1|AF159714_1 [Homo sapiens] HPJDA08 958182 741 blastx.14 zinc finger 5 protein gi|1399185|gb|AAB3 39% 92 475 [Gallus gallus] 8387.1| HPJET90 836503 750 HMMER PFAM: Aldehyde PF00171 150.4 66 371 2.1.1 dehydrogenase family HPMEG50 925080 806 blastx.14 Mst84Dc [Drosophila gi|11075|emb|CAA47 62% 7 30 melanogaster] 939.1| 28% 22 105 44% 126 152 HPMFL08 959569 819 HMMER PFAM: Src homology PF00018 4.97 209 238 1.8 domain 3 HPMGF06 954823 845 blastx.14 GTP binding protein [Mus gi|53169|emb|CAA36 92% 37 564 musculus] 803.1| HPMGI03 924521 848 blastx.14 (AF106933) plexin B gi|4056676|gb|AAD0 36% 49 147 [Drosophila melanogaster] 9426.1| 60% 148 177 63% 12 44 43% 288 335 66% 359 385 HPMGX23 575903 864 HMMER PFAM: Helix-loop-helix PF00010 6.66 96 194 1.8 DNA-binding domain HPMJF76 965642 875 blastx.14 pol protein [Human gi|1780973|emb|CAA 58% 234 326 endogenous retrovirus K] 71417.1| 40% 28 138 63% 134 199 HPMJN59 946876 877 HMMER PFAM: Prolyl PF00326 21.87 138 251 1.8 oligopeptidase family blastx.2 (AC005594) R26984_1 gb|AAC33801.1| 61% 138 521 [Homo sapiens] HPMKM81 894416 884 HMMER PFAM: Homeobox PF00046 82.2 94 228 2.1.1 domain HPRCC08 939490 901 blastx.14 2.19 [Homo sapiens] gi|854082|emb|CAA6 54% 120 296 0645.1| HPWAS77 908450 914 HMMER PFAM: gag gene protein PF00607 92.3 655 266 2.1.1 p24 (core nucleocapsid protein) blastx.14 gag protein [Human gi|1780975|emb|CAA 37% 730 248 endogenous retrovirus K] 71418.1| 38% 185 108 45% 253 188 50% 25 2 HSWAC73 710354 926 HMMER PFAM: WD domain, G- PF00400 9.99 134 190 1.8 beta repeats HTEAL28 963538 939 blastx.14 (AL080154) hypothetical gi|5262611|emb|CAB 36% 234 413 protein [Homo sapiens] 45745.1| HTEBC74 887782 945 HMMER PFAM: Armadillo PF00514 20.2 58 183 1.8 segment protein, repeats HTEBY08 960427 954 HMMER PFAM: Protein PF01240 92.8 63 251 2.1.1 phosphatase 2A regulatory subunit PR55 blastx.14 protein phosphatase 2A1 gi|619215|gb|AAA58 97% 63 197 B gamma subunit 956.1| 87% 231 254 [Oryctolagus cuniculus] HTECA21 911369 962 HMMER PFAM: PDZ domain PF00595 57.6 100 354 2.1.1 (Also known as DHR or GLGF). blastx.14 tyrosine phosphatase gi|1486367|emb|CAA 57% 85 351 [Homo sapiens] 56124.1| 51% 467 652 HTEDI02 921243 994 HMMER PFAM: Leucine Rich PF00560 36.2 346 414 2.1.1 Repeat blastx.14 densin-180 [Rattus gi|1657758|gb|AAC5 36% 220 450 norvegicus] 2881.1| 32% 214 450 34% 220 456 30% 241 450 33% 214 453 26% 214 441 29% 214 450 36% 268 450 36% 463 612 24% 220 453 26% 214 453 40% 463 588 29% 463 606 29% 463 606 31% 463 606 29% 463 603 24% 463 612 HTEDQ30 530589 1007 HMMER PFAM: Ferritins PF00210 104.6 9 164 2.1.1 HTEDU48 932315 1013 blastx.14 (AF176069) ubiquilin gi|5733824|gb|AAD4 66% 11 118 [Homo sapiens] 9751.1|AF176069_1 46% 305 454 55% 587 688 57% 452 535 24% 251 472 28% 293 388 26% 332 502 15% 311 490 24% 569 679 32% 184 267 25% 329 436 HTEDY38 771505 1017 HMMER PFAM: Zinc-binding PF00099 2.19 9 44 1.8 metalloprotease domain HTEDY54 922964 1018 blastx.14 lysozyme [Gallus gallus] gi|63426|emb|CAA43 46% 696 457 319.1| 41% 405 220 61% 234 181 HTEGM38 675087 1059 HMMER PFAM: DnaJ domain PF00226 65.2 93 197 2.1.1 HTEGO05 932583 1061 HMMER PFAM: Eukaryotic protein PF00069 50.8 3 233 2.1.1 kinase domain blastx.14 male germ cell-associated gi|205278|gb|AAA41 85% 3 395 kinase (mak) [Rattus 562.1| 64% 489 761 norvegicus] 85% 768 848 38% 1023 1100 HTEHC47 973071 1085 blastx.2 unnamed protein product emb|CAB42447.1| 29% 112 612 [unidentified] HTEHI14 526687 1096 HMMER PFAM: lactate/malate PF00056 50.6 222 371 2.1.1 dehydrogenase HTEHS19 529280 1113 HMMER PFAM: 7 transmembrane PF00002 19.3 16 135 2.1.1 receptor (Secretin family) HTEHV72 920610 1117 HMMER PFAM: IQ calmodulin- PF00612 41.7 178 240 2.1.1 binding motif HTEIB14 963099 1127 HMMER PFAM: Zinc finger, C2H2 PF00096 53.9 78 146 2.1.1 type blastx.14 Bowel [Drosophila gi|1388166|gb|AAB1 90% 9 236 melanogaster] 7949.1| 33% 9 230 80% 227 316 33% 9 230 46% 9 149 28% 54 230 31% 230 334 35% 224 316 32% 307 381 32% 297 380 34% 358 426 HTEIF40 958355 1128 blastx.14 (AF132972) CGI-38 gi|4680715|gb|AAD2 64% 117 275 protein [Homo sapiens] 7747.1|AF132972_1 HTEIK11 967431 1136 blastx.14 Zfb-29 [Mus musculus] gi|55471|emb|CAA38 28% 188 367 920.1| 50% 353 406 50% 353 406 50% 353 406 50% 353 406 44% 353 406 61% 368 406 47% 356 406 42% 60 137 38% 353 406 44% 356 409 100% 411 431 85% 411 431 85% 411 431 87% 408 431 100% 414 431 HTEIL07 953803 1139 HMMER PFAM: EF hand PF00036 11.27 192 263 1.8 HTEIP88 941155 1148 HMMER PFAM: Transmembrane PF01490 34.7 1 216 2.1.1 amino acid transporter protein HTEIU92 870652 1154 HMMER PFAM: Transketolase PF00456 70.1 1 225 2.1.1 HTEIV54 922027 1155 blastx.14 p18H-rev 107 [Rattus gi|433963|emb|CAA5 40% 359 682 norvegicus] 3991.1| 65% 251 364 HTEIY80 955242 1163 blastx.14 (AF146793) protein B gi|4836805|gb|AAD3 91% 320 454 [Mus musculus] 0564.1|AF146793_1 74% 453 569 83% 111 203 31% 257 322 HTEJE15 908360 1170 HMMER PFAM: Helicases PF00271 14.92 5 52 1.8 conserved C-terminal domain blastx.14 vasa-like gene protein, gi|806464|gb|AAB33 73% 2 190 RVLG protein = putative 364.1| 84% 242 319 DEAD 1 [Rattus sp.] 65% 188 265 HTEJF45 942476 1172 HMMER PFAM: Zinc-binding PF00099 2.28 593 637 1.8 metalloprotease domain blastx.2 (AB017800) nolp [Homo dbj|BAA34576.1| 69% 135 299 sapiens] 53% 290 487 77% 523 549 37% 540 629 HTEJP10 914785 1180 HMMER PFAM: Heat shock hsp90 PF00183 13.29 110 214 1.8 proteins HTEJP66 916481 1181 blastx.14 (AF151885) CGI-127 gi|4929723|gb|AAD3 100% 499 639 protein [Homo sapiens] 4122.1|AF151885_1 62% 626 706 HTEKS20 846714 1210 HMMER PFAM: EF hand PF00036 84.7 453 539 2.1.1 HTELE10 963563 1221 blastx.14 integumentary mucin B.1 gi|1184035|emb|CAA 75% 339 244 [Xenopus laevis] 64795.1| HTELJ89 966134 1229 HMMER PFAM: Zinc-binding PF00099 2.6 290 316 1.8 metalloprotease domain HTELV86 910946 1252 HMMER PFAM: Fibronectin type PF00041 77.22 400 669 1.8 III domain blastx.14 neural cell adhesion gi|1016012|gb|AAC5 96% 1 918 protein BIG-2 precursor 2262.1| 68% 960 1025 [Rattus norvegicus] 92% 926 967 66% 22 75 28% 1 171 55% 1 54 28% 286 399 42% 10 93 44% 280 354 33% 274 390 33% 286 357 100% 1028 1054 42% 184 225 100% 1057 1077 28% 658 741 HTEMA54 911666 1260 HMMER PFAM: Actin PF00022 320.7 247 1161 2.1.1 blastx. 14 actin [Girardia tigrina] gi|4204812|gb|AAD1 42% 253 849 1530.1| 44% 955 1161 55% 1232 1360 48% 847 927 58% 1169 1204 HTEMK03 923066 1273 blastx.14 (AF116463) unknown gi|4455041|gb|AAD2 37% 302 216 [Streptomyces 1045.1| 53% 171 127 lincolnensis] 47% 348 292 53% 55 17 35% 231 181 42% 190 134 42% 134 78 58% 43 8 HTEMP49 932319 1280 blastx.14 (AL117564) hypothetical gi|5912114|emb|CAB 91% 12 629 protein [Homo sapiens] 55995.1| HTEMR65 909280 1281 HMMER PFAM: Zinc finger, C2H2 PF00096 51.5 35 103 2.1.1 type blastx.2 zinc finger protein [Homo emb|CAA55533.1| 61% 2 286 sapiens] 56% 2 286 56% 2 286 54% 2 292 52% 2 286 50% 2 304 53% 2 286 51% 2 286 51% 2 286 53% 5 286 51% 2 283 52% 5 286 51% 2 283 40% 909 998 45% 866 931 HTEMT06 934338 1284 blastx.14 120 kDa style gi|2653671|gb|AAC1 28% 50 280 glycoprotein [Nicotiana 5893.1| 37% 240 383 alata] 32% 80 226 HTEMX92 913795 1288 HMMER PFAM: BTB/POZ domain PF00651 62.3 122 319 2.1.1 blastx.14 (AF086831) gi|3599513|gb|AAC3 47% 143 337 leukemia/lymohoma 5368.1| 32% 331 450 related factor cLRF [Gallus gallus] HTENI58 917213 1299 HMMER PFAM: HMG (high PF00505 118.2 308 514 2.1.1 mobility group) box blastx.14 HMG-X protein [Xenopus gi|639691|dbj|BAA06 43% 269 514 laevis] 440.1| 43% 101 319 26% 89 214 57% 446 487 HTENP54 787535 1306 HMMER PFAM: Bacterial PF00196 6.37 107 199 1.8 regulatory proteins, luxR family HTENP80 775387 1307 HMMER PFAM: TPR Domain PF00515 11.77 83 166 1.8 HTENR10 963530 1309 blastx.14 protein kinase related to gi|1171248|gb|AAC5 82% 10 132 Raf protein kinases; 1 0354.1| HTENR93 920834 1311 blastx.14 (AF121781) unknown gi|4210989|gb|AAD1 79% 285 644 [Homo sapiens] 2066.1| 74% 620 808 HTENY35 884043 1319 HMMER PFAM: Zinc finger, PF00097 6.56 449 592 1.8 C3HC4 type (RING finger) HTEOF80 847224 1327 HMMER PFAM: EGF-like domain PF00008 14.65 20 100 1.8 HTEOI36 870575 1330 HMMER PFAM: HMG (high PF00505 15.44 69 236 1.8 mobility group) box HTEON29 815852 1333 HMMER PFAM: EF hand PF00036 22.29 266 349 1.8 HTEOV90 870532 1336 HMMER PFAM: Core histones PF00125 11.37 358 435 1.8 H2A, H2B, H3 and H4 HTEOW39 870566 1338 HMMER PFAM: C-type lysozymes PF00062 126.92 59 295 1.8 and alpha-lactabulmin HTEPA08 958391 1340 blastx.14 (AF004430) hD54 + ins2 gi|2895085|gb|AAC9 47% 225 482 isoform [Homo sapiens] 8478.1| 67% 483 575 HTEPE28 932576 1347 HMMER PFAM: metallopeptidase PF00557 203 2 442 2.1.1 family M24 blastx.14 (AC002387) putative gi|2583129|gb|AAB8 68% 2 442 methionine 2638.1| 51% 408 488 aminopeptidase [Arabidopsis thaliana] HTEPM33 870561 1354 HMMER PFAM: LIM domain PF00412 95.6 4 180 2.1.1 containing proteins HTEPN07 952243 1356 blastx.14 WW domain binding gi|4205086|gb|AAD1 54% 174 311 protein-2 [Homo sapiens] 0951.1| 42% 9 158 HTEPP30 947107 1359 blastx.14 (AF081947) tektin [Mus gi|4235350|gb|AAD1 73% 30 689 musculus] 3183.1| 21% 72 590 HTEPV02 917406 1366 HMMER PFAM: Ank repeat PF00023 30.4 343 435 2.1.1 blastx.14 alt. ankyrin (variant 2.2) gi|747710|emb|CAA3 41% 247 411 [Homo sapiens] 4611.1| HTEPX32 870698 1367 HMMER PFAM: Double-stranded PF00035 36 508 699 1.8 RNA binding motif HTEQD40 915198 1371 blastx.14 (AC004877) sco-spondin- gi|3638957|gb|AAC3 30% 278 171 mucin-like; similar to 6301.1| 33% 266 195 P98167 1 sapiens] 43% 188 141 45% 506 447 54% 110 78 42% 121 65 25% 260 177 HTEQE87 958354 1373 blastx.14 (AF132972) CGI-38 gi|4680715|gb|AAD2 50% 334 645 protein [Homo sapiens] 7747.1|AF132972_1 58% 149 349 HTEQP45 966141 1379 HMMER PFAM: HMG (high PF00505 5.99 7 48 1.8 mobility group) box HTEQR15 939641 1381 HMMER PFAM: 4 transmembrane PF00335 32.9 174 455 1.8 segments integral membrane proteins blastx.2 (AF133424) tetraspanin gb|AAF08363.1|AF1 74% 141 698 TM4-B [Homo sapiens] 33424_1 HTEQT63 924799 1383 HMMER PFAM: Bacterial mutT PF00293 3.53 472 501 1.8 protein HTLCA95 911655 1398 HMMER PFAM: Actin PF00022 345.2 170 1096 2.1.1 blastx. 14 actin 2 [Echinococcus gi|290399|gb|AAC80 50% 170 568 granulosus] 574.1| 42% 761 1096 53% 677 760 45% 593 652 63% 2 34 HTLCY54 908832 1402 HMMER PFAM: DnaJ domain PF00226 119.8 245 445 2.1.1 blastx.14 (AB014888) MRJ [Homo gi|3402485|dbj|BAA3 67% 239 616 sapiens] 2209.1| 78% 797 934 47% 632 694 40% 611 691 HTLDE64 908613 1407 HMMER PFAM: Zinc finger, C2H2 PF00096 47.6 197 271 2.1.1 type blastx.2 Kruppel-like factor LKLF gb|AAA86728.1| 61% 179 355 [Mus musculus] 42% 57 176 HTLDF33 909254 1409 HMMER PFAM: Zinc finger, C2H2 PF00096 80.8 51 119 2.1.1 type blastx.2 (AL022067) dJ134E15.1 emb|CAB36862.1| 70% 12 422 (Blimp-1) [Homo sapiens] 38% 24 392 HTLDG55 911645 1410 blastx.14 actin [Trypanosoma gi|161963|gb|AAA30 48% 95 199 brucei] 151.1| 58% 28 63 HTLDO94 915223 1413 blastx.14 (AC004667) hypothetical gi|3668087|gb|AAC6 37% 96 263 protein [Arabidopsis 1819.1| 34% 108 263 thaliana] 37% 108 242 44% 40 93 30% 37 105 38% 40 93 29% 43 93 HTLDS55 891322 1416 HMMER PFAM: Cell division PF00735 454.7 233 1069 2.1.1 protein blastx.2 (AJ250723) septin-like emb|CAB59833.1| 63% 131 1054 protein Sint1 [Mus musculus] HTLDT05 909752 1417 HMMER PFAM: PH domain PF00169 36.9 59 271 2.1.1 blastx.2 (AK000004) FLJ00004 dbj|BAA92229.1| 77% 47 487 protein [Homo sapiens] HTLDU05 911649 1419 HMMER PFAM: Actins PF00022 141.45 125 469 1.8 blastx.14 (AF113908) actin-related gi|4731565|gb|AAD2 30% 2 469 protein [Emericella 8502.1|AF113908_1 33% 451 540 nidulans] HTLEH30 934287 1429 blastx.14 (AF025310) tssk-1 and gi|2739052|gb|AAC0 90% 205 270 tssk-2 kinase substrate 3366.1| 58% 343 429 [Mus musculus] 81% 306 338 HTLEJ11 973302 1431 HMMER PFAM: Eukaryotic protein PF00069 55.9 44 223 2.1.1 kinase domain blastx.14 (AF144573) Mx- gi|4868443|gb|AAD3 69% 35 268 interacting protein kinase 1319.1|AF144573_1 40% 437 592 PKM [Mesocricetus 42% 293 397 auratus] 38% 877 939 HTLET56 911654 1444 HMMER PFAM: Actins PF00022 262.03 134 703 1.8 blastx. 14 actin [Filobasidiella gi|508701|gb|AAC49 52% 143 715 neoformans] 074.1| 33% 787 963 53% 721 804 52% 966 1022 HTLET78 836820 1445 HMMER PFAM: Proprotein PF01483 216.9 38 433 2.1.1 convertase P-domain HTLEV95 883332 1448 HMMER PFAM: Phorbol esters/ PF00130 1.97 172 225 1.8 diacylglycerol binding domain HTLEY11 967309 1451 blastx.14 (AC004877) sco-spondin- gi|3638957|gb|AAC3 66% 267 250 mucin-like; similar to 6301.1| P98167 1 sapiens] HTLFE05 954984 1459 blastx.14 (AJ007798) nuclear gi|5834580|emb|CAB 86% 12 731 protein SA3 [i Homo 55312.1| 65% 589 924 sapiens] HTLFI39 953730 1462 blastx.2 (AF053356) ORF4 [Homo gb|AAC78801.1| 100% 77 256 sapiens] 100% 3 77 100% 376 420 HTLGD25 870136 1465 HMMER PFAM: Ubiquitin family PF00240 83.86 79 324 1.8 HTLGM07 952254 1470 HMMER PFAM: ‘Cold-shock’ PF00313 70.2 3 158 2.1.1 DNA-binding domain blastx.14 (AF096834) germ cell gi|4837737|gb|AAD3 90% 3 323 specific Y-box binding 0662.1| 100% 393 485 protein [Homo sapiens] 100% 549 614 100% 711 761 36% 661 750 28% 637 720 34% 117 203 40% 475 519 63% 487 519 HTLGT62 918606 1471 blastx.14 a6(IV) collagen [Homo gi|1850097|dbj|BAA0 48% 187 261 sapiens] 9791.1| 38% 379 456 61% 503 541 40% 113 178 80% 232 261 61% 181 219 53% 229 273 37% 196 276 42% 14 70 66% 181 207 HTLGX90 870528 1473 HMMER PFAM: UBX domain PF00789 20.1 637 846 2.1.1 HTLHC14 908428 1474 HMMER PFAM: ‘Cold-shock’ PF00313 36.8 9 95 2.1.1 DNA-binding domain blastx.14 (AF096834) germ cell gi|4837737|gb|AAD3 88% 3 260 specific Y-box binding 0662.1| 92% 330 443 protein [Homo sapiens] 62% 424 528 100% 539 577 37% 539 625 34% 397 483 50% 519 572 70% 584 613 28% 509 634 23% 342 479 34% 54 140 37% 460 531 30% 256 363 30% 402 479 HTLHP32 933335 1478 HMMER PFAM: RNA recognition PF00076 24.08 195 284 1.8 motif. (aka RRM, RBD, or RNP domain) HTLHT15 946586 1481 blastx.14 (AL032626) cDNA EST gi|3925211|emb|CAA 43% 1 243 EMBL:D70654 comes 21539.1| 66% 287 358 from this 1 1 1 yk377b8.3 50% 402 455 comes f 58% 235 270 39% 240 308 HTLHV67 936139 1484 blastx.14 (AF005038) secretory gi|5230678|gb|AAB6 83% 152 475 carrier membrane protein 2723.2| 60% 591 749 [Homo sapiens] 96% 465 542 66% 2 46 HTLHZ10 963475 1486 blastx.14 circumsporozoite protein gi|482882|gb|AAC46 37% 3 137 [Plasmodium vivax] 499.1| 35% 3 137 33% 3 137 35% 45 137 45% 128 187 45% 181 240 45% 234 293 40% 128 187 50% 234 281 50% 340 387 40% 181 240 40% 128 187 40% 128 187 50% 287 334 50% 287 334 40% 234 293 40% 128 187 40% 181 240 50% 234 281 50% 340 387 40% 287 346 50% 128 175 50% 258 293 50% 205 240 50% 311 346 HTLID36 945891 1488 blastx.2 (AC004410) fos39554_1 gb|AAC05601.1| 54% 6 275 [Homo sapiens] 71% 292 417 57% 257 319 HTLIY52 942161 1495 HMMER PFAM: Eukaryotic protein PF00069 251.19 166 933 1.8 kinase domain blastx.2 serine/threonine kinase gb|AAA99535.1| 44% 133 936 [Mus musculus] HTLJA23 953729 1496 blastx.2 (AF053356) ORF4 [Homo gb|AAC78801.1| 100% 2 274 sapiens] 100% 394 438 HTLJC71 922923 1498 HMMER PFAM: Src homology PF00018 9.14 1152 1340 1.8 domain 3 blastx.2 (AL133030) hypothetical emb|CAB61362.1| 94% 3 1355 protein [Homo sapiens] HTLJD88 953714 1500 blastx.14 (AF025310) tssk-1 and gi|2739052|gb|AAC0 83% 3 206 tssk-2 kinase substrate 3366.1| 74% 554 715 [Mus musculus] 95% 263 391 72% 516 548 77% 468 494 63% 510 542 32% 260 334 60% 21 50 HTLJJ75 924755 1501 HMMER PFAM: Coenzyme A PF01144 317.7 445 813 2.1.1 transferase blastx.14 succinyl-CoA:alpha- gi|164423|gb|AAA31 85% 448 813 ketoacid coenzyme A 019.1| 65% 37 405 transferase [Sus scrofa] 80% 813 977 79% 980 1096 HTTBJ94 530564 1515 HMMER PFAM: Protein of PF01871 63.2 18 254 2.1.1 unknown function HTTCT34 973210 1521 HMMER PFAM: Divalent cation PF01769 46.7 93 251 2.1.1 transporter blastx.2 (AK000480) unnamed dbj|BAA91192.1| 89% 466 972 protein product [Homo 96% 105 491 sapiens] 58% 861 1049 HTTDO19 908937 1532 HMMER PFAM: Zinc finger, C2H2 PF00096 42.8 22 90 2.1.1 type blastx.2 zinc finger protein [Homo emb|CAA55529.1| 76% 1 129 sapiens] 72% 1 129 45% 1 237 67% 1 129 44% 1 237 67% 1 129 50% 13 234 63% 125 190 36% 180 287 71% 149 190 90% 161 190 36% 180 287 36% 180 287 57% 180 221 50% 180 227 HTTEU68 967819 1543 blastx.14 glycosyl-phosphatidyl- gi|1098569|gb|AAA8 36% 26 190 inositol-anchored protein 2599.1| 52% 536 649 homolog [Mus musculus] 32% 197 352 52% 759 827 43% 377 424 HTTFM66 950051 1556 blastx.2 (AK001269) unnamed dbj|BAA91592.1| 84% 195 1124 protein product [Homo sapiens] HTTKP07 911390 1587 HMMER PFAM: Src homology PF00018 15.82 47 196 1.8 domain 3 blastx.2 (AL049683) hypothetical emb|CAB41255.1| 51% 8 289 protein [Homo sapiens] 56% 292 450 HUKAC72 966804 1594 blastx.14 DARPP-32 = DOPAMINE sp|G545790|G545790 81% 73 309 AND CAMP- REGULATED PHOSPHOPROTEIN. HUVCQ07 928053 1612 blastx.14 SHB = SRC HOMOLOGY sp|G545100|G545100 44% 102 251 2 PROTEIN. 52% 6 68 HUVFH03 922064 1639 HMMER PFAM: FAD/NAD- PF00175 6.83 282 323 1.8 binding domain in oxidoreductases HUVGZ77 909169 1650 HMMER PFAM: BTB/POZ domain PF00651 51.2 110 253 2.1.1 blastx.14 (AB011665) BAZF [Mus gi|3287501|dbj|BAA3 94% 47 301 musculus] 1223.1| 87% 295 366 HUVHC93 908555 1653 HMMER PFAM: KRAB box PF01352 152.7 147 335 2.1.1 blastx.14 ha0946 protein is gi|498152|dbj|BAA06 64% 135 362 Kruppel-related. [Homo 541.1| 55% 72 131 sapiens] HVCAZ38 969208 1659 blastx.2 (AK000496) unnamed dbj|BAA91205.1| 64% 395 159 protein product [Homo 75% 151 110 sapiens] HVVBK72 933167 1668 HMMER PFAM: UDP- PF00201 70.01 2 391 1.8 glucoronosyl and UDP- glucosyl transferases HWLHJ68 957834 1671 HMMER PFAM: Zinc finger, C2H2 PF00096 6.35 216 278 1.8 type blastx.14 (AB012265) wizL [Mus gi|3551182|dbj|BAA3 55% 201 314 musculus] 2790.1| 39% 101 169 HVVBY08 957658 1673 HMMER PFAM: Sm protein PF01423 79.4 134 355 2.1.1 blastx.14 (AC005258) R30783_1 gi|3289993|gb|AAC2 97% 185 403 [Homo sapiens] 5622.1| 100% 130 195 HUVGP05 930892 1677 blastx.14 (AF091457) zinc finger gi|4557143|gb|AAD2 82% 231 398 protein RIN ZF [Rattus 2522.1|AF091457_1 100% 217 246 norvegicus] HUVFI01 945834 1679 blastx.2 similar to human TRAMP dbj|BAA06540.1| 98% 103 1212 protein. [Homo sapiens] HUNAF20 961527 1693 blastx.14 (AF184971) cytokine gi|6013325|gb|AAF01 100% 382 278 receptor homolog 1 320.1|AF184971_1 HUNAE02 921132 1696 blastx.14 (AF151848) CGI-90 gi|4929649|gb|AAD3 100% 2 94 protein [Homo sapiens] 4085.1|AF151848_1 HUKEP18 957456 1710 HMMER PFAM: Trypsin PF00089 82.96 729 361 1.8 blastx.2 (AF100707) testes- gb|AAF22500.1|AF1 100% 118 588 specific protein TSP50 00707_1 [Homo sapiens] HUKDG10 968333 1713 blastx.14 F35D2.4 gene product gi|861294|gb|AAA68 47% 3 314 [Caenorhabditis elegans] 328.1| HTTJN26 869612 1744 blastx.2 cDNA EST yk338f6.5 emb|CAB04553.1| 35% 587 345 comes from this gene; 50% 666 589 cDNA EST EMBL:D75296 comes from this gene [Caenorhabditis elegans] HTTIR04 926772 1748 blastx.14 (AF092091) cp431 gi|3851160|gb|AAC7 45% 462 163 [Rattus norvegicus] 2234.1| 26% 195 118 HTTDM42 460948 1762 HMMER PFAM: KRAB box PF01352 79.1 282 401 2.1.1 HTTBP62 932997 1771 blastx.14 (AF036705) Similar to gi|2749982|gb|AAB9 69% 64 336 phytoene desaturase; 5172.1| 68% 373 468 coded for 1 1 1 coded for HTLHK57 946914 2662 blastx.14 acetylcholine receptor gi|595481|gb|AAA56 76% 783 938 alpha 9 subunit [Rattus 720.1| 71% 586 720 rattus] HTLHB93 945862 1797 blastx.2 (AJ006692) ultra high emb|CAA07188.1| 40% 21 272 sulfer keratin [Homo 39% 21 272 sapiens] HTLGS10 963458 1799 blastx.14 pro-alpha-2(I) collagen gi|50489|emb|CAA41 34% 108 212 [Mus musculus] 205.1| 50% 380 433 26% 186 320 53% 302 340 HTLEQ92 932882 1804 blastx.14 (AL117444) hypothetical gi|5911890|emb|CAB 100% 6 107 protein [Homo sapiens] 55929.1| 100% 203 256 36% 213 269 HTLEN77 772363 1806 HMMER PFAM: EF hand PF00036 26.93 294 380 1.8 HTLDZ81 778180 1810 HMMER PFAM: Tubulin PF00091 12.29 156 245 1.8 HTLDW27 961353 1811 blastx.14 (AF014461) EXO70 gi|2352998|gb|AAB6 95% 239 601 protein [Mus musculus] 9345.1| 100% 186 236 88% 76 126 76% 1 51 63% 36 68 HTLBH67 751985 1821 HMMER PFAM: Src homology PF00018 37.78 16 162 1.8 domain 3 HTFBE02 920507 1830 HMMER PFAM: Isopentenyl- PF01772 95.6 103 291 2.1.1 diphosphate delta- isomerase HTEQN83 908528 1834 HMMER PFAM: KRAB box PF01352 98.7 81 203 2.1.1 blastx.14 (AL080125) hypothetical gi|5262560|emb|CAB 62% 75 251 protein [Homo sapiens] 45723.1| 66% 39 74 HTEPE35 948475 1838 HMMER PFAM: PF00387 163.8 839 507 2.1.1 Phosphatidylinositol- specific phospholipase C, Y domain blastx.2 1-phosphatidylinositol- pir|S14113|S14113 48% 1 750 4,5-bisphosphate phosphodiesterase 1 HTEOY82 948845 1839 blastx.14 (AJ010949) calcium gi|4186073|emb|CAA 97% 165 374 channel alpha-2-delta-C 09423.1| subunit [Mus musculus] HTEMV66 813038 1852 HMMER PFAM: Eukaryotic protein PF00069 27.8 154 315 2.1.1 kinase domain HTEMU66 944419 1853 HMMER PFAM: Eukaryotic protein PF00069 114.85 613 963 1.8 kinase domain blastx.2 MEK Kinase 3 [Mus gb|AAB03535.1| 49% 604 948 musculus] 29% 209 340 HTEMO58 964769 1855 blastx.14 casein kinase 1 gamma 1 gi|854733|gb|AAC52 82% 395 195 isoform [Rattus 200.1| 65% 482 423 norvegicus] 87% 424 401 77% 214 188 HTEKH17 942526 1867 blastx.2 (AF016184) putative gb|AAC53331.1| 70% 300 88 pheromone receptor 53% 602 378 [Rattus norvegicus] 52% 85 29 HTEGJ74 765901 1892 HMMER PFAM: Tudor domain PF00567 38.5 6 167 2.1.1 HTEDH90 909165 1924 HMMER PFAM: BTB/POZ domain PF00651 38.1 195 308 2.1.1 blastx.14 (AF097916) HIV-1 gi|3860089|gb|AAC7 45% 150 308 inducer of short 2973.1| 39% 348 416 transcripts binding protein [Homo sapiens] HTEDH42 615250 1926 HMMER PFAM: ADP-ribosylation PF00025 156.4 42 353 2.1.1 factor family HTEDF22 908406 1935 HMMER PFAM: Zinc finger, PF00098 20.37 250 297 1.8 CCHC class blastx.2 nucleic acid binding gb|AAA89198.1| 46% 52 303 protein [Mus sp.] HTECC09 678659 1952 HMMER PFAM: Zinc finger, PF00097 14.18 261 338 1.8 C3HC4 type (RING finger) blastx.2 (AF151048) HSPC214 gb|AAF36134.1|AF1 85% 111 332 [Homo sapiens] 51048_1 HPWTA06 936026 1982 blastx.14 Collagenase precursor gi|1742347|dbj|BAA1 100% 624 454 (EC 3.4.-.-). [Escherichia 5068.1| 100% 359 207 coli] 100% 457 362 58% 216 115 64% 169 86 HPWSA52 727294 1983 HMMER PFAM: Homeobox PF00046 11.67 215 262 1.8 domain HPWAJ39 575271 1993 HMMER PFAM: Phorbol esters/ PF00130 2.68 81 122 1.8 diacylglycerol binding domain HPRAG45 939849 2672 HMMER PFAM: WD domain, G- PF00400 21.65 135 212 1.8 beta repeats HPMGR15 660374 2040 HMMER PFAM: Phorbol esters/ PF00130 2.84 307 333 1.8 diacylglycerol binding domain HPLAI10 968707 2074 blastx.14 AT motif-binding factor gi|1345408|dbj|BAA0 33% 443 496 [Mus musculus] 5046.1| HPJEV95 929723 2076 HMMER PFAM: ATP synthase A PF00119 20.61 169 393 1.8 chain HPJDT03 922815 2083 HMMER PFAM: WW/rsp5/WWP PF00397 9.71 294 371 1.8 domain containing proteins HPJDA25 951281 2087 blastx.2 (AF047690) ATP-binding gb|AAD15748.1| 73% 291 488 cassette protein M-ABC1 [Homo sapiens] HPJDA25 951284 2676 blastx.14 (AF047690) ATP-binding gi|4321407|gb|AAD1 87% 219 97 cassette protein M-ABC1 5748.1| [Homo sapiens] HPIAQ70 973604 2130 HMMER PFAM: Flagella basal PF00460 41.51 206 298 1.8 body rod proteins blastx.14 Flagellar hook-associated gi|1651528|dbj|BAA3 77% 322 498 protein 1 (hap1). 5891.1| 100% 194 322 [Escherichia coli] HPCTD03 922149 2191 HMMER PFAM: Pterin 4 alpha PF01329 143.1 6 305 2.1.1 carbinolamine dehydratase blastx.14 pterin-4a-carbinolamine gi|848985|gb|AAA69 62% 18 311 dehydratase [Homo 662.1| sapiens] HPCOV68 911075 2195 blastx.14 (AC004500) GDF-9 gi|2996640|gb|AAC0 64% 2 160 [Homo sapiens] 8450.1| HPCAO89 946913 2196 HMMER PFAM: Serpins (serine PF00079 53.12 94 309 1.8 protease inhibitors) blastx.2 leupin [Homo sapiens] emb|CAA61420.1| 39% 82 327 45% 309 452 HOVEE20 909030 2207 HMMER PFAM: KRAB box PF01352 105.4 229 348 2.1.1 blastx.14 zinc finger protein 30 gi|456269|emb|CAA8 67% 193 348 [Mus musculus 2913.1| 33% 367 429 domesticus] HOVCO50 932544 2211 HMMER PFAM: Zinc-binding PF00099 2.22 464 508 1.8 metalloprotease domain blastx.14 (AF072860) protein gi|3290198|gb|AAC2 82% 458 577 activator of the 1 5672.1| 43% 204 251 HOOKF04 925784 2244 blastx.14 (AF092091) cp431 gi|3851160|gb|AAC7 94% 2 157 [Rattus norvegicus] 2234.1| 94% 158 265 29% 5 127 27% 5 115 HOOJN04 925783 2246 blastx.14 (AF011336) putative E1- gi|2944187|gb|AAC0 100% 4 153 E2 ATPase [Mus 5245.1| musculus] HONAD02 859016 2261 HMMER PFAM: Polyprenyl PF00348 38.5 753 905 2.1.1 synthetases HOGAM56 908904 2276 blastx.14 ZINC FINGER [CLONE sp|G299838|G299838 63% 6 179 ZNF78L1]. 68% 3 152 56% 33 176 50% 188 235 46% 191 235 HOFNW65 815822 2286 HMMER PFAM: Calpain family PF00648 34.2 18 89 2.1.1 cysteine protease HOFNW07 953436 2288 HMMER PFAM: Cytochrome c/cl PF01265 21.1 259 354 2.1.1 heme lyase blastx.14 holocytochrome c-type gi|1209635|gb|AAB1 71% 190 360 synthetase [Homo 9007.1| 83% 139 192 sapiens] HOFNI10 964682 2301 blastx.14 similar to Human zinc- gi|1504012|dbj|BAA1 100% 150 269 finger protein, 3205.1| 90% 64 153 BR140(P1:JC2069) 100% 271 291 [Homo sapiens] 66% 293 319 HOFNC80 835718 2303 HMMER PFAM: IG PF00047 11.98 148 291 1.8 (immunoglobulin) superfamily blastx (AF111714) junctional gb|AAD42051.1|AF1 71% 28 303 adhesion molecule [Bos 11714_1 94% 306 362 taurus] 33% 306 359 HOFMT55 888552 2311 HMMER PFAM: Caspase PF00619 43 111 239 2.1.1 recruitment domain HOFMS43 947973 2313 HMMER PFAM: Sushi domain PF00084 64 174 302 2.1.1 (SCR repeat) blastx.2 porcine membrane dbj|BAA20476.1| 47% 12 317 cofactor protein [Sus scrofa] HOFMP09 943358 2315 HMMER PFAM: Immunoglobulin PF00047 27.5 34 144 2.1.1 domain blastx B-CAM [Homo sapiens] emb|CAA56327.1| 76% 31 351 49% 300 494 85% 473 553 33% 247 372 46% 283 327 43% 91 138 HOFMF82 693987 2317 HMMER PFAM: Zinc finger, C2H2 PF00096 10.91 44 106 1.8 type HOFMF82 694062 2688 HMMER PFAM: Zinc finger, C2H2 PF00096 53.7 372 440 2.1.1 type HOFMF82 909248 2689 HMMER PFAM: Zinc finger, C2H2 PF00096 48.3 61 129 2.1.1 type blastx.14 zinc finger protein [Homo gi|495568|gb|AAC50 52% 19 429 sapiens] 264.1| 50% 55 429 50% 25 402 44% 79 429 28% 4 66 HOFAF25 942367 2320 blastx.2 (AF036696) contains gb|AAB88349.1| 39% 289 969 similarity to Brassica oleracea non-green 1 (GB:U13632) [Caenorhabditis elegans] HODFF88 974911 2341 HMMER PFAM: Eukaryotic protein PF00069 101.43 98 370 1.8 kinase domain blastx.14 mixed-lineage protein pir|S32467|JU0229 74% 131 493 kinase 1 - human 81% 763 921 30% 751 915 HODFD73 909812 2343 HMMER PFAM: GTPase-activator PF00616 34 190 390 2.1.1 protein for Ras-like GTPase blastx.14 (AB016962) synGAP-b1 gi|4417207|dbj|BAA7 98% 4 480 [Rattus norvegicus] 4972.1| HODCZ64 745966 2357 blastx.2 elastin like protein emb|CAA59990.1| 75% 3 86 [Drosophila melanogaster] 42% 364 405 42% 358 399 HODAK55 745532 2383 HMMER PFAM: ATPases PF00004 60.69 11 157 1.8 associated with various cellular activities (AAA) HOCPH02 917453 2400 HMMER PFAM: Zinc finger, PF00097 8.27 265 309 1.8 C3HC4 type (RING finger) HNIAB26 974750 2412 blastx.14 PR-1-like protein gi|166861|gb|AAA32 37% 388 143 [Arabidopsis thaliana] 863.1| HLWFB01 915399 2419 blastx.14 (AL117637) hypothetical gi|5912226|emb|CAB 94% 155 328 protein [Homo sapiens] 56026.1| HLWBC21 869611 2443 HMMER PFAM: Src homology PF00018 3.29 350 379 1.8 domain 3 HLWBA27 931387 2445 blastx.14 (AF070657) glutathione gi|4454690|gb|AAD2 93% 89 286 S-transferase subunit 13 0963.1| 75% 486 533 homolog [Homo sapiens] 100% 277 306 HLWAW86 941397 2692 HMMER PFAM: Integrins alpha PF00357 163.29 115 459 1.8 chain HLWAR08 959139 2448 HMMER PFAM: Ank repeat PF00023 13.97 3 44 1.8 HLWAL31 971312 2693 HMMER PFAM: Leucine rich PF01463 51.7 317 466 2.1.1 repeat C-terminal domain blastx.2 (AF133270) SLIT2 gb|AAD25539.1|AF1 89% 77 565 [Homo sapiens] 33270_1 37% 77 481 35% 92 505 30% 92 553 72% 495 524 57% 493 534 HJMAU07 961623 2466 blastx.14 (AB016088) RNA binding gi|5821145|dbj|BAA8 75% 321 1 protein [Homo sapiens] 3714.1| HETLF29 909762 2471 HMMER PFAM: Eukaryotic protein PF00069 143.18 6 416 1.8 kinase domain blastx.14 similar to cAMP- gi|3878636|emb|CAA 56% 6 416 dependant protein kinase; 88953.1| cDNA EST 1 1 1 HETBE61 965638 2483 blastx.14 (AF151833) CGI-75 gi|4929619|gb|AAD3 88% 347 526 protein [Homo sapiens] 4070.1|AF151833_1 77% 247 339 93% 318 365 81% 215 262 HEQCC01 924849 2488 blastx.14 (AF151878) CGI-120 gi|4929709|gb|AAD3 73% 892 422 protein [Homo sapiens] 4115.1|AF151878_1 69% 343 266 HEQBG85 827915 2492 HMMER PFAM: Peroxidases PF00141 24.44 13 162 1.8 HEQAD73 914044 2500 blastx.14 (AL023286) hypothetical gi|3116115|emb|CAA 38% 319 444 protein 18866.1| 39% 463 546 [Schizosaccharomyces 70% 203 232 pombe] HEPCB04 941270 2502 blastx.14 (AF153605) androgen gi|5231135|gb|AAD4 97% 524 387 induced protein [Homo 1087.1|AF153605_1 sapiens] HEPAJ04 933091 2513 blastx.14 (AL034368) predicted gi|4760337|emb|CAB 44% 95 148 using hexExon; L779.3,1 39078.2| 87% 302 325 50% 201 236 50% 1 42 45% 230 262 HEGBC03 922550 2516 blastx.14 similar to collagen gi|3873667|emb|CAA 57% 252 293 [Caenorhabditis elegans] 94874.1| 66% 229 255 HEEAX09 912065 2525 HMMER PFAM: lipocalins PF00061 12.2 86 205 1.8 blastx.14 epididymal secretory gi|56117|emb|CAA42 39% 86 208 protein I (ESP I) [Rattus 493.1| 39% 8 76 norvegicus] 33% 206 259 HEEAG51 930810 2533 blastx.14 (AF083108) sirtuin type 3 gi|5225322|gb|AAD4 82% 94 282 [Homo sapiens] 0851.1|AF083108_1 75% 260 295 HUCOMM05 925952 2554 HMMER PFAM: Src homology PF00018 59.48 178 342 1.8 domain 3 blastx.2 epidermal growth factor gb|AAA62280.1| 46% 445 840 receptor kinase substrate 43% 115 435 [Homo sapiens] 23% 43 222 HCHOX63 957690 2556 blastx.14 CDC42 GTPase- gi|409027|gb|AAA16 64% 112 597 activating protein [Homo 142.1| 78% 661 702 sapiens] HCHNW48 862478 2557 HMMER PFAM: Laminin B PF00052 1.52 230 289 1.8 (Domain IV) HCHMW18 966985 2559 blastx.14 (AB017614) OASIS gi|4519621|dbj|BAA7 100% 538 386 protein [Mus musculus] 5670.1| 68% 440 222 39% 308 240 HCHMI15 935298 2562 blastx.14 PSD-95/SAP90-associated gi|1864093|gb|AAB4 52% 181 582 protein-4 [Rattus 8590.1| 75% 682 825 norvegicus] 91% 584 691 50% 620 667 HCHAI62 743411 2570 HMMER PFAM: Core histones PF00125 8.45 2 76 1.8 H2A, H2B, H3 and H4 HCDMC22 672815 2578 HMMER PFAM: Core histones PF00125 9.49 182 241 1.8 H2A, H2B, H3 and H4 HBGTT76 903653 2619 HMMER PFAM: Ank repeat PF00023 62.3 197 295 2.1.1 blastx.14 (AJ133120) Proline rich gi|5262748|emb|CAB 72% 131 556 synapse associated protein 45688.1| 47% 499 561 2 [Rattus norvegicus] HBGMT82 954374 2624 blastx.14 (AJ004801) very large gi|2653311|emb|CAA 37% 187 267 virion protein (tegument) 06097.1| 35% 91 201 [Bovine herpesvirus type 32% 91 201 1.1] HBGDF39 861602 2631 HMMER PFAM: Response PF00072 44.82 158 355 1.8 regulator receiver domain HBCPV80 932817 2639 HMMER PFAM: WW domain PF00397 64.2 71 160 2.1.1 HAQCD07 958959 2649 blastx.14 (AC005581) R31237_1, gi|3510234|gb|AAC3 100% 1 108 partial CDS [Homo 3487.1| sapiens]

[0088] Table 2 further characterizes certain encoded polypeptides of the invention, by providing the results of comparisons to protein and protein family databases. The first column provides a unique clone identifier, “Clone ID NO:”, corresponding to a cDNA clone disclosed in Table 1A. The second column provides the unique contig indentifier, “Contig ID:” which allows correlation with the information in Table 1A. The third column provides the sequence identifier, “SEQ ID NO: X”, for the contig polynucleotide sequences. The fourth column provides the analysis method by which the homology/identity disclosed in the row was determined. The fifth column provides a description of PFam/NR hits having significant matches identified by each analysis. Column six provides the accession number of the PFam/NR hit disclosed in the fifth column. Column seven, “Score/Percent Identity”, provides a quality score or the percent identity, of the hit disclosed in column five. Comparisons were made between polypeptides encoded by polynucleotides of the invention and a non-redundant protein database (herein referred to as “NR”), or a database of protein families (herein referred to as “PFam”), as described below.

[0089] The NR database, which comprises the NBRF PIR database, the NCBI GenPept database, and the SIB SwissProt and TrEMBL databases, was made non-redundant using the computer program nrdb2 (Warren Gish, Washington University in Saint Louis). Each of the polynucleotides shown in Table 1A, column 3 (e.g., SEQ ID NO: X or the ‘Query’sequence) was used to search against the NR database. The computer program BLASTX was used to compare a 6-frame translation of the Query sequence to the NR database (for information about the BLASTX algorithm please see Altshul et al., J. Mol. Biol. 215:403-410 (1990), and Gish et al., Nat. Genet. 3:266-272 (1993)). A description of the sequence that is most similar to the Query sequence (the highest scoring ‘Subject’) is shown in column five of Table 2 and the database accession number for that sequence is provided in column six. The highest scoring ‘Subject’ is reported in Table 2 if (a) the estimated probability that the match occurred by chance alone is less than 1.0 e-07, and (b) the match was not to a known repetitive element. BLASTX returns alignments of short polypeptide segments of the Query and Subject sequences which share a high degree of similarity; these segments are known as High-Scoring Segment Pairs or HSPs. Table 2 reports the degree of similarity between the Query and the Subject for each HSP as a percent identity in Column 7. The percent identity is determined by dividing the number of exact matches between the two aligned sequences in the HSP, dividing by the number of Query amino acids in the HSP and multiplying by 100. The polynucleotides of SEQ ID NO: X which encode the polypeptide sequence that generates an HSP are delineated by columns 8 and 9 of Table 2.

[0090] The PFam database, PFam version 5.2, (Sonnhammer et al., Nucl. Acids Res., 26:320-322, (1998)) consists of a series of multiple sequence alignments; one alignment for each protein family. Each multiple sequence alignment is converted into a probability model called a Hidden Markov Model, or HMM, that represents the position-specific variation among the sequences that make up the multiple sequence alignment (see, e.g., R. Durbin et al., Biological sequence analysis: probabilistic models of proteins and nucleic acids, Cambridge University Press, 1998 for the theory of HMMs). The program HMMER version 1.8 (Sean Eddy, Washington University in Saint Louis) was used to compare the predicted protein sequence for each Query sequence (SEQ ID NO: Y in Table 1A) to each of the HMMs derived from PFam version 5.2. A HMM derived from PFam version 5.2 was said to be a significant match to a polypeptide of the invention if the score returned by HMMER 1.8 was greater than 0.8 times the HMMER 1.8 score obtained with the most distantly related known member of that protein family. The description of the PFam family which shares a significant match with a polypeptide of the invention is listed in column 5 of Table 2, and the database accession number of the PFam hit is provided in column 6. Column 7 provides the score returned by HMMER version 1.8 for the alignment. Columns 8 and 9 delineate the polynucleotides of SEQ ID NO: X which encode the polypeptide sequence which shows a significant match to a PFam protein family.

[0091] As mentioned, columns 8 and 9 in Table 2, “NT From” and “NT To”, delineate the polynucleotides of “SEQ ID NO: X” that encode a polypeptide having a significant match to the PFam/NR database as disclosed in the fifth column of Table 2. In one embodiment, the invention provides a protein comprising, or alternatively consisting of, a polypeptide encoded by the polynucleotides of SEQ ID NO: X delineated in columns 8 and 9 of Table 2. Also provided are polynucleotides encoding such proteins, and the complementary strand thereto.

[0092] The nucleotide sequence SEQ ID NO: X and the translated SEQ ID NO: Y are sufficiently accurate and otherwise suitable for a variety of uses well known in the art and described further below. For instance, the nucleotide sequences of SEQ ID NO: X are useful for designing nucleic acid hybridization probes that will detect nucleic acid sequences contained in SEQ ID NO: X or the cDNA contained in Clone ID NO: Z. These probes will also hybridize to nucleic acid molecules in biological samples, thereby enabling immediate applications in chromosome mapping, linkage analysis, tissue identification and/or typing, and a variety of forensic and diagnostic methods of the invention. Similarly, polypeptides identified from SEQ ID NO: Y may be used to generate antibodies which bind specifically to these polypeptides, or fragments thereof, and/or to the polypeptides encoded by the cDNA clones identified in, for example, Table 1A.

[0093] Nevertheless, DNA sequences generated by sequencing reactions can contain sequencing errors. The errors exist as misidentified nucleotides, or as insertions or deletions of nucleotides in the generated DNA sequence. The erroneously inserted or deleted nucleotides cause frame shifts in the reading frames of the predicted amino acid sequence. In these cases, the predicted amino acid sequence diverges from the actual amino acid sequence, even though the generated DNA sequence may be greater than 99.9% identical to the actual DNA sequence (for example, one base insertion or deletion in an open reading frame of over 1000 bases).

[0094] Accordingly, for those applications requiring precision in the nucleotide sequence or the amino acid sequence, the present invention provides not only the generated nucleotide sequence identified as SEQ ID NO: X, and a predicted translated amino acid sequence identified as SEQ ID NO: Y, but also a sample of plasmid DNA containing cDNA Clone ID NO: Z (deposited with the ATCC on Oct. 5, 2000, and receiving ATCC designation numbers PTA 2574 and PTA 2575; deposited with the ATCC on Jan. 5, 2001, having the depositor reference numbers TS-1, TS-2, AC-1, and AC-2; and/or as set forth, for example, in Table 1A, 6 and 7). The nucleotide sequence of each deposited clone can readily be determined by sequencing the deposited clone in accordance with known methods. Further, techniques known in the art can be used to verify the nucleotide sequences of SEQ ID NO: X.

[0095] The predicted amino acid sequence can then be verified from such deposits. Moreover, the amino acid sequence of the protein encoded by a particular clone can also be directly determined by peptide sequencing or by expressing the protein in a suitable host cell containing the deposited human cDNA, collecting the protein, and determining its sequence.

[0096] RACE Protocol For Recovery of Full-Length Genes

[0097] Partial cDNA clones can be made full-length by utilizing the rapid amplification of cDNA ends (RACE) procedure described in Frohman, M.A., et al., Proc. Nat'l. Acad. Sci. USA, 85:8998-9002 (1988). A cDNA clone missing either the 5′ or 3′ end can be reconstructed to include the absent base pairs extending to the translational start or stop codon, respectively. In some cases, cDNAs are missing the start codon of translation. The following briefly describes a modification of this original 5′ RACE procedure. Poly A+ or total RNA is reverse transcribed with Superscript II (Gibco/BRL) and an antisense or complementary primer specific to the cDNA sequence. The primer is removed from the reaction with a Microcon Concentrator (Amicon). The first-strand cDNA is then tailed with dATP and terminal deoxynucleotide transferase (Gibco/BRL). Thus, an anchor sequence is produced which is needed for PCR amplification. The second strand is synthesized from the dA-tail in PCR buffer, Taq DNA polymerase (Perkin-Elmer Cetus), an oligo-dT primer containing three adjacent restriction sites (XhoI, SalI and ClaI) at the 5′ end and a primer containing just these restriction sites. This double-stranded cDNA is PCR amplified for 40 cycles with the same primers as well as a nested cDNA-specific antisense primer. The PCR products are size-separated on an ethidium bromide-agarose gel and the region of gel containing cDNA products the predicted size of missing protein-coding DNA is removed. cDNA is purified from the agarose with the Magic PCR Prep kit (Promega), restriction digested with XhoI or SalI, and ligated to a plasmid such as pBluescript SKII (Stratagene) at XhoI and EcoRV sites. This DNA is transformed into bacteria and the plasmid clones sequenced to identify the correct protein-coding inserts. Correct 5′ ends are confirmed by comparing this sequence with the putatively identified homologue and overlap with the partial cDNA clone. Similar methods known in the art and/or commercial kits are used to amplify and recover 3′ ends.

[0098] Several quality-controlled kits are commercially available for purchase. Similar reagents and methods to those above are supplied in kit form from Gibco/BRL for both 5′ and 3′ RACE for recovery of full length genes. A second kit is available from Clontech which is a modification of a related technique, SLIC (single-stranded ligation to single-stranded cDNA), developed by Dumas et al., Nucleic Acids Res., 19:5227-32 (1991). The major differences in procedure are that the RNA is alkaline hydrolyzed after reverse transcription and RNA ligase is used to join a restriction site-containing anchor primer to the first-strand cDNA. This obviates the necessity for the dA-tailing reaction which results in a polyT stretch that is difficult to sequence past.

[0099] An alternative to generating 5′ or 3′ cDNA from RNA is to use cDNA library double-stranded DNA. An asymmetric PCR-amplified antisense cDNA strand is synthesized with an antisense cDNA-specific primer and a plasmid-anchored primer. These primers are removed and a symmetric PCR reaction is performed with a nested cDNA-specific antisense primer and the plasmid-anchored primer.

[0100] RNA Ligase Protocol for Generating the 5′ or 3′ End Sequences to Obtain Full Length Genes

[0101] Once a gene of interest is identified, several methods are available for the identification of the 5′ or 3′ portions of the gene which may not be present in the original cDNA plasmid. These methods include, but are not limited to, filter probing, clone enrichment using specific probes and protocols similar and identical to 5′ and 3′ RACE. While the full length gene may be present in the library and can be identified by probing, a useful method for generating the 5′ or 3′ end is to use the existing sequence information from the original cDNA to generate the missing information. A method similar to 5′ RACE is available for generating the missing 5′ end of a desired full-length gene. (This method was published by Fromont-Racine et al., Nucleic Acids Res., 21(7):1683-1684 (1993)). Briefly, a specific RNA oligonucleotide is ligated to the 5′ ends of a population of RNA presumably containing full-length gene RNA transcript. A primer set containing a primer specific to the ligated RNA oligonucleotide and a primer specific to a known sequence of the gene of interest, is used to PCR amplify the 5′ portion of the desired full length gene which may then be sequenced and used to generate the full length gene. This method starts with total RNA isolated from the desired source, poly A RNA may be used but is not a prerequisite for this procedure. The RNA preparation may then be treated with phosphatase if necessary to eliminate 5′ phosphate groups on degraded or damaged RNA which may interfere with the later RNA ligase step. The phosphatase, if used, is then inactivated and the RNA is treated with tobacco acid pyrophosphatase in order to remove the cap structure present at the 5′ ends of messenger RNAs. This reaction leaves a 5′ phosphate group at the 5′ end of the cap cleaved RNA which can then be ligated to an RNA oligonucleotide using T4 RNA ligase. This modified RNA preparation can then be used as a template for first strand cDNA synthesis using a gene specific oligonucleotide. The first strand synthesis reaction can then be used as a template for PCR amplification of the desired 5′ end using a primer specific to the ligated RNA oligonucleotide and a primer specific to the known sequence of the reproductive system antigen of interest. The resultant product is then sequenced and analyzed to confirm that the 5′ end sequence belongs to the relevant reproductive system antigen.

[0102] The present invention also relates to vectors or plasmids, which include such DNA sequences, as well as the use of the DNA sequences. The material deposited with the ATCC (deposited with the ATCC on Oct. 5, 2000, and receiving ATCC designation numbers PTA 2574 and PTA 2575; deposited with the ATCC on Jan. 5, 2001, having the depositor reference numbers TS-1, TS-2, AC-1, and AC-2; and/or as set forth, for example, in Table 1A, 6 and 7) is a mixture of cDNA clones derived from a variety of human tissue and cloned in either a plasmid vector or a phage vector, as shown, for example, in Table 7. These deposits are referred to as “the deposits” herein. The tissues from which some of the clones were derived are listed in Table 7, and the vector in which the corresponding cDNA is contained is also indicated in Table 7. The deposited material includes cDNA clones corresponding to SEQ ID NO: X described, for example, in Table 1A (Clone ID NO: Z). A clone which is isolatable from the ATCC Deposits by use of a sequence listed as SEQ ID NO: X, may include the entire coding region of a human gene or in other cases such clone may include a substantial portion of the coding region of a human gene. Furthermore, although the sequence listing may in some instances list only a portion of the DNA sequence in a clone included in the ATCC Deposits, it is well within the ability of one skilled in the art to sequence the DNA included in a clone contained in the ATCC Deposits by use of a sequence (or portion thereof) described in, for example Tables 1A or 2 by procedures hereinafter further described, and others apparent to those skilled in the art.

[0103] Also provided in Table 7 is the name of the vector which contains the cDNA clone. Each vector is routinely used in the art. The following additional information is provided for convenience.

[0104] Vectors Lambda Zap (U.S. Pat. Nos. 5,128,256 and 5,286,636), Uni-Zap XR (U.S. Pat. Nos. 5,128,256 and 5,286,636), Zap Express (U.S. Pat. Nos. 5,128,256 and 5,286,636), pBluescript (pBS) (Short, J. M. et al., Nucleic Acids Res. 16:7583-7600 (1988); Alting-Mees, M. A. and Short, J. M., Nucleic Acids Res. 17:9494 (1989)) and pBK (Alting-Mees, M. A. et al., Strategies 5:58-61 (1992)) are commercially available from Stratagene Cloning Systems, Inc., 11011 N. Torrey Pines Road, La Jolla, Calif., 92037. pBS contains an ampicillin resistance gene and pBK contains a neomycin resistance gene. Phagemid pBS may be excised from the Lambda Zap and Uni-Zap XR vectors, and phagemid pBK may be excised from the Zap Express vector. Both phagemids may be transformed into E. coli strain XL-1 Blue, also available from Stratagene.

[0105] Vectors pSport1, pCMVSport 1.0, pCMVSport 2.0 and pCMVSport 3.0, were obtained from Life Technologies, Inc., P. O. Box 6009, Gaithersburg, Md. 20897. All Sport vectors contain an ampicillin resistance gene and may be transformed into E. coli strain DH10B, also available from Life Technologies. See, for instance, Gruber, C. E., et al., Focus 15:59-(1993). Vector lafmid BA (Bento Soares, Columbia University, New York, N.Y.) contains an ampicillin resistance gene and can be transformed into E. coli strain XL-1 Blue. Vector pCR®2.1, which is available from Invitrogen, 1600 Faraday Avenue, Carlsbad, Calif. 92008, contains an ampicillin resistance gene and may be transformed into E. coli strain DH10B, available from Life Technologies. See, for instance, Clark, J. M., Nuc. Acids Res. 16:9677-9686 (1988) and Mead, D. et al., Bio/Technology 9: (1991).

[0106] The present invention also relates to the genes corresponding to SEQ ID NO: X, SEQ ID NO: Y, and/or the deposited clone (Clone ID NO: Z). The corresponding gene can be isolated in accordance with known methods using the sequence information disclosed herein. Such methods include preparing probes or primers from the disclosed sequence and identifying or amplifying the corresponding gene from appropriate sources of genomic material.

[0107] Also provided in the present invention are allelic variants, orthologs, and/or species homologs. Procedures known in the art can be used to obtain full-length genes, allelic variants, splice variants, full-length coding portions, orthologs, and/or species homologs of reproductive system associated genes corresponding to SEQ ID NO: X or the complement thereof, polypeptides encoded by SEQ ID NO: X or the complement thereof, and/or the cDNA contained in Clone ID NO: Z, using information from the sequences disclosed herein or the clones deposited with the ATCC. For example, allelic variants and/or species homologs may be isolated and identified by making suitable probes or primers from the sequences provided herein and screening a suitable nucleic acid source for allelic variants and/or the desired homologue.

[0108] The polypeptides of the invention can be prepared in any suitable manner. Such polypeptides include isolated naturally occurring polypeptides, recombinantly produced polypeptides, synthetically produced polypeptides, or polypeptides produced by a combination of these methods. Means for preparing such polypeptides are well understood in the art.

[0109] The polypeptides may be in the form of the secreted protein, including the mature form, or may be a part of a larger protein, such as a fusion protein (see below). It is often advantageous to include an additional amino acid sequence which contains secretory or leader sequences, pro-sequences, sequences which aid in purification, such as multiple histidine residues, or an additional sequence for stability during recombinant production.

[0110] The polypeptides of the present invention are preferably provided in an isolated form, and preferably are substantially purified. A recombinantly produced version of a polypeptide, including the secreted polypeptide, can be substantially purified using techniques described herein or otherwise known in the art, such as, for example, by the one-step method described in Smith and Johnson, Gene 67:31-40 (1988). Polypeptides of the invention also can be purified from natural, synthetic or recombinant sources using techniques described herein or otherwise known in the art, such as, for example, antibodies of the invention raised against the reproductive system polypeptides of the present invention in methods which are well known in the art.

[0111] The present invention provides a polynucleotide comprising, or alternatively consisting of, the nucleic acid sequence of SEQ ID NO: X, and/or the cDNA sequence contained in Clone ID NO: Z. The present invention also provides a polypeptide comprising, or alternatively, consisting of, the polypeptide sequence of SEQ ID NO: Y, a polypeptide encoded by SEQ ID NO: X or a complement thereof, a polypeptide encoded by the cDNA contained in Clone ID NO: Z, and/or the polypeptide sequence encoded by a nucleotide sequence in SEQ ID NO: B as defined in column 6 of Table 1B. Polynucleotides encoding a polypeptide comprising, or alternatively consisting of the polypeptide sequence of SEQ ID NO: Y, a polypeptide encoded by SEQ ID NO: X, a polypeptide encoded by the cDNA contained in Clone ID NO: Z and/or a polypeptide sequence encoded by a nucleotide sequence in SEQ ID NO: B as defined in column 6 of Table 1B are also encompassed by the invention. The present invention further encompasses a polynucleotide comprising, or alternatively consisting of, the complement of the nucleic acid sequence of SEQ ID NO: X, a nucleic acid sequence encoding a polypeptide encoded by the complement of the nucleic acid sequence of SEQ ID NO: X, and/or the cDNA contained in Clone ID NO: Z.

[0112] Moreover, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in Table 1B column 6, or any combination thereof. Additional, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the complementary strand(s) of the sequences delineated in Table 1B column 6, or any combination thereof. In further embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in Table 1B, column 6, and have a nucleic acid sequence which is different from that of the BAC fragment having the sequence disclosed in SEQ ID NO: B (see Table 1B, column 5). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in Table 1B, column 6, and have a nucleic acid sequence which is different from that published for the BAC clone identified as BAC ID NO: A (see Table 1B, column 4). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in Table 1B, column 6, and have a nucleic acid sequence which is different from that contained in the BAC clone identified as BAC ID NO: A (see Table 1B, column 4). Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides and polypeptides are also encompassed by the invention.

[0113] Further, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in column 6 of Table 1B which correspond to the same Clone ID NO: Z (see Table 1B, column 1), or any combination thereof. Additional, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the complementary strand(s) of the sequences delineated in column 6 of Table 1B which correspond to the same Clone ID NO: Z (see Table 1B, column 1), or any combination thereof. In further embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in column 6 of Table 1B which correspond to the same Clone ID NO: Z (see Table 1B, column 1) and have a nucleic acid sequence which is different from that of the BAC fragment having the sequence disclosed in SEQ ID NO: B (see Table 1B, column 5). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in column 6 of Table 1B which correspond to the same Clone ID NO: Z (see Table 1B, column 1) and have a nucleic acid sequence which is different from that published for the BAC clone identified as BAC ID NO: A (see Table 1B, column 4). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in column 6 of Table 1B which correspond to the same Clone ID NO: Z (see Table 1B, column 1) and have a nucleic acid sequence which is different from that contained in the BAC clone identified as BAC ID NO: A (see Table 1B, column 4). Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides and polypeptides are also encompassed by the invention.

[0114] Further, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in column 6 of Table 1B which correspond to the same contig sequence identifer SEQ ID NO: X (see Table 1B, column 2), or any combination thereof. Additional, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the complementary strand(s) of the sequences delineated in column 6 of Table 1B which correspond to the same contig sequence identifer SEQ ID NO: X (see Table 1B, column 2), or any combination thereof. In further embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in column 6 of Table 1B which correspond to the same contig sequence identifer SEQ ID NO: X (see Table 1B, column 2) and have a nucleic acid sequence which is different from that of the BAC fragment having the sequence disclosed in SEQ ID NO: B (see Table 1B, column 5). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in column 6 of Table 1B which correspond to the same contig sequence identifer SEQ ID NO: X (see Table 1B, column 2) and have a nucleic acid sequence which is different from that published for the BAC clone identified as BAC ID NO: A (see Table 1B, column 4). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in column 6 of Table 1B which correspond to the same contig sequence identifer SEQ ID NO: X (see Table 1B, column 2) and have a nucleic acid sequence which is different from that contained in the BAC clone identified as BAC ID NO: A (See Table 1B, column 4). Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides and polypeptides are also encompassed by the invention.

[0115] Moreover, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in the same row of Table 1B column 6, or any combination thereof. Additional, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the complementary strand(s) of the sequences delineated in the same row of Table 1B column 6, or any combination thereof. In preferred embodiments, the polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the complementary strand(s) of the sequences delineated in the same row of Table 1B column 6, wherein sequentially delineated sequences in the table (i.e. corresponding to those exons located closest to each other) are directly contiguous in a 5′ to 3′ orientation. In further embodiments, above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in the same row of Table 1B, column 6, and have a nucleic acid sequence which is different from that of the BAC fragment having the sequence disclosed in SEQ ID NO: B (see Table 1B, column 5). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in the same row of Table 1B, column 6, and have a nucleic acid sequence which is different from that published for the BAC clone identified as BAC ID NO: A (see Table 1B, column 4). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in the same row of Table 1B, column 6, and have a nucleic acid sequence which is different from that contained in the BAC clone identified as BAC ID NO: A (see Table 1B, column 4). Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.

[0116] In additional specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in column 6 of Table 1B, and the polynucleotide sequence of SEQ ID NO: X (e.g., as defined in Table 1B, column 2) or fragments or variants thereof. Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.

[0117] In additional specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in column 6 of Table 1B which correspond to the same Clone ID NO: Z (see Table 1B, column 1), and the polynucleotide sequence of SEQ ID NO: X (e.g., as defined in Table 1A or 1B) or fragments or variants thereof. In preferred embodiments, the delineated sequence(s) and polynucleotide sequence of SEQ ID NO: X correspond to the same Clone ID NO: Z. Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.

[0118] In further specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in the same row of column 6 of Table 1B, and the polynucleotide sequence of SEQ ID NO: X (e.g., as defined in Table 1A or 1B) or fragments or variants thereof. In preferred embodiments, the delineated sequence(s) and polynucleotide sequence of SEQ ID NO: X correspond to the same row of column 6 of Table 1B. Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.

[0119] In additional specific embodiments, polynucleotides of the invention comprise, or alternatively consist of a polynucleotide sequence in which the 3′ 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B and the 5′ 10 polynucleotides of the sequence of SEQ ID NO: X are directly contiguous. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.

[0120] In additional specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, a polynucleotide sequence in which the 3′ 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B and the 5′ 10 polynucleotides of a fragment or variant of the sequence of SEQ ID NO: X are directly contiguous Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.

[0121] In specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, a polynucleotide sequence in which the 3′ 10 polynucleotides of the sequence of SEQ ID NO: X and the 5′ 10 polynucleotides of the sequence of one of the sequences delineated in column 6 of Table 1B are directly contiguous. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.

[0122] In specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, a polynucleotide sequence in which the 3′ 10 polynucleotides of a fragment or variant of the sequence of SEQ ID NO: X and the 5′ 10 polynucleotides of the sequence of one of the sequences delineated in column 6 of Table 1B are directly contiguous. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides, are also encompassed by the invention.

[0123] In further specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, a polynucleotide sequence in which the 3′ 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B and the 5′ 10 polynucleotides of another sequence in column 6 are directly contiguous. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.

[0124] In specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, a polynucleotide sequence in which the 3′ 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B and the 5′ 10 polynucleotides of another sequence in column 6 corresponding to the same Clone ID NO: Z (see Table 1B, column 1) are directly contiguous. Nucleic acids which hybridize to the complement of these 20 lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.

[0125] In specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, a polynucleotide sequence in which the 3′ 10 polynucleotides of one sequence in column 6 corresponding to the same contig sequence identifer SEQ ID NO: X (see Table 1B, column 2) are directly contiguous. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.

[0126] In specific embodiments, polynucleotides of the invention comprise, or alternatively consist of a polynucleotide sequence in which the 3′ 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B and the 5′ 10 polynucleotides of another sequence in column 6 corresponding to the same row are directly contiguous. In preferred embodiments, the 3′ 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B is directly contiguous with the 5′ 10 polynucleotides of the next sequential exon delineated in Table 1B, column 6. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.

[0127] Many polynucleotide sequences, such as EST sequences, are publicly available and accessible through sequence databases and may have been publicly available prior to conception of the present invention. Preferably, such related polynucleotides are specifically excluded from the scope of the present invention. Accordingly, for each contig sequence (SEQ ID NO: X) listed in the third column of Table 1A, preferably excluded are one or more polynucleotides comprising a nucleotide sequence described by the general formula of a−b, where a is any integer between 1 and the final nucleotide minus 15 of SEQ ID NO: X, b is an integer of 15 to the final nucleotide of SEQ ID NO: X, where both a and b correspond to the positions of nucleotide residues shown in SEQ ID NO: X, and where b is greater than or equal to a+14. More specifically, preferably excluded are one or more polynucleotides comprising a nucleotide sequence described by the general formula of a−b, where a and b are integers as defined in columns 4 and 5, respectively, of Table 3. In specific embodiments, the polynucleotides of the invention do not consist of at least one, two, three, four, five, ten, or more of the specific polynucleotide sequences referenced by the Genbank Accession No. as disclosed in column 6 of Table 3 (including for example, published sequence in connection with a particular BAC clone). In further embodiments, preferably excluded from the invention are the specific polynucleotide sequence(s) contained in the clones corresponding to at least one, two, three, four, five, ten, or more of the available material having the accession numbers identified in the sixth column of this Table (including for example, the actual sequence contained in an identified BAC clone). In no way is this listing meant to encompass all of the sequences which may be excluded by the general formula, it is just a representative example. All references available through these accessions are hereby incorporated by reference in their entirety. TABLE 3 SEQ ID EST Disclaimer Clone ID NO: Contig Range Range NO:Z X ID; of a of b Accession #'s H7MCE35 11 928554 1-59 15-73 H7MDC49 12 722780 1-148 15-162 AI139000, AA884996, AA889649, and AA724461. H7MDD72 13 847688 1-592 15-606 AW182856, AI218191, AA834537, AA804628, AA827835, AF034780, and E07989. HAOSH55 14 952380 1-694 15-708 AI681511, AA677498, AI799484, AI360937, AI378075, AI457270, AI363333, AI681227, AI806180, AI363339, AA972313, AA627925, AI984311, AA483815, N25951, AI250808, AI417147, AW297301, AI079688, AW009637, AI289263, AA768395, AA769533, AW085089, AW368116, AW067835, AI110587, N26848, W15533, AI129095, AW298190, AI300955, AI870137, AW410019, AI808400, AA748383, AA479673, AW269239, AA281561, AA807144, AW291197, AW373450, and N42781. HAQAK73 15 764671 1-728 15-742 H93040, H93056, AA719305, AA808945, AI342677, AA742815, AC006581, AP000045, AP000113, AC007684, AC002404, AC003070, AC003042, AP000327, AC003043, AC005829, AB023048, AP000123, AP000170, AP000055, AC007066, AC002350, AC005399, AL135744, AC005031, AF001549, AC004913, Z95114, AL031663, AL008729, Z97054, AL133355, AC000381, AC005207, AC009516, U80017, Z81370, AC006023, AC006449, AC005296, AC005069, AC000118, AC004821, AC006146, AC005037, AC006441, AL109798, AL031432, AL080243, AC004819, AL109627, AC002477, and AC004882. HAQAM17 16 664979 1-347 15-361 HAQBF84 17 783259 1-56 15-70 HAQBJ71 18 839982 1-409 15-423 HAQBQ50 19 522004 1-83 15-97 HAQBS37 20 847519 1-710 15-724 AW168869, and AI904433. HAUBD69 21 529711 1-121 15-135 HAUBU10 22 968339 1-324 15-338 AW419224, AW419225, and AW419223. HBCJS08 23 957826 1-492 15-506 AL119483, AA809125, AL119444, AA835346, AA188940, AC016027, AC016830, AC005529, AC005261, AC004531, AC005255, AC006137, AC006080, AL049874, AL132777, L44140, AL031983, AC006515, AC004659, Z85987, AC005531, AF134726, AC006441, AC004858, AF053356, AP000552, AC005740, AP000503, AC012627, AC004882, AC003108, AC007934, AL049758, AC005181, AF109907, AC004033, AC005091, AC007685, AC005971, AC003663, AC005274, AC005089, AL049829, AC006449, U96629, AC004973, AL049872, AC007283, AC005057, AC004231, AL035413, AL078638, AC006023, AC005815, AL031311, AL023803, AC005821, AL049780, AL031228, AC005919, AP000555, AL049631, AC004895, AC005072, AC005736, AL021155, AL022165, AL133448, AL133245, AC007055, AL008718, AC004526, AC007065, AL049776, U07563, AL035681, AP000114, AP000046, AF205588, AC005231, AC005841, AC004491, AC007193, AC007878, AL031591, AF038458, AL049869, AC012384, AC003002, AL133485, AL109984, AC004983, AL121653, AC005049, AG005839, AC002418, AC004386, D84401, AC003037, AC002091, AL049538, AC002070, AF045555, Z93244, AC006468, AL022316, AC006141, AC004854, AC005067, AC005768, AC007993, AL008719, AC004522, AC004099, AC006512, AC005088, AC004884, AL031427, AD000092, AC005624, AL109758, Z70281, AC004859, AC005081, AL079295, AC002425, AB026898, AC004985, AL035072, AC005484, AC004816, AC005914, AL121754, AC004890, AC005746, AL121757, Z86090, AL109627, AL133163, AC000003, AC009721, Z82250, AC007057, and AC005071. HBCPD14 24 963634 1-127 15-141 HBCQJ03 25 922401 1-124 15-138 AW392670, Z99396, AL119319, AL036418, AL036858, AW372827, AW384394, AL119457, AL119483, AL119324, AW363220, AL119484, AL119391, AL119497, AL119522, U46351, AL119418, AL119355, AL119443, AL119363, AL037094, AL119341, U46341, AL134902, AL119396, U46349, AL119401, U46350, U46347, AL042551, AL037205, AL119335, AL119496, AL119439, AL134536, AL036196, AL037082, AL119444, AL134525, AL036268, U46346, AL038837, AL042614, AL134920, AL043019, AL042984, AL037051, AL042965, AL042975, AL036725, AL042544, AA631969, AL119399, AL134538, U46345, AL042542, AL043029, AL042450, AL043003, AL036924, AL037526, AL119464, AR066494, AR060234, A81671, AB026436, AD001527, AR054110, AR023813, AR064707, and AR069079. HBCQS90 26 951787 1-507 15-521 AA191298, AW364854, AI205727, R16601, and AI188004. HBCQS93 27 930682 1-607 15-621 AA703200, W88470, and Z39990. HBGBD28 28 525846 1-314 15-328 HBGBFS6 29 957870 1-240 15-254 HBGBG42 30 922396 1-689 15-703 N33183, AA169202, AI393342, AW172574, AA731731, AI961101, AA872188, W17122, AI219418, AA609341, AA485152, AW293905, AI221103, AI910881, AW195626, AA856740, AA767183, AW072218, AA929018, AI338682, AA836394, AA448345, AW293908, AI264116, W26762, AA766127, AA761418, H30745, AA315954, AI022328, AI032738, AI203338, HBGBH43 31 524532 1-183 15-197 AI863446, AI188331, AW014913, AI073437, AW291378, AI130693,AI768987, and HBGBS07 32 954299 1-403 15-417 AA229977, N41881, N23545, H78888, H54240, AW270016, and AAS69612. HBGBT79 33 525352 1-318 15-332 HBGBW60 34 954916 1-555 15-569 AI808278, AI697307, AI936570, AW167940, AI379188, AI669686, AI751739, AW450137, AI868311, AI203915, AW182104, AW014255, AI766481, AI821507, AA548667, AA194990, AF061970, U81600, and X52875. HBGBW72 35 524956 1-321 15-335 HBGDA44 36 525618 1-493 15-507 HBGDE85 37 524875 1-125 15-139 HBGDS13 38 971696 1-245 15-259 HBGDT43 39 974223 1-433 15-447 AI567076, AW270343, AA169263, AW275510, AI801482, AA362511, AI933534, AA847499, AA580808, AA226363, AA502104, AI311927, AA569471, AL042753, AL048925, AA502860, AI133297, AI499588, AW021583, AA531079, AW248819, F25733, AW341900, AA101689, R86151, AA494102, AA482923, AA715255, AA715267, AA516222, AA758934, AI783494, AA602047, AI751216, AA664909, T60681, AA320966, AL119691, AA428792, AA828042, AI445674, AW062724, AA493695, AW302013, AA469451, AI281881, AW193461, AI919265, AA484679, AA632612, AI085719, AA601202, AA653375, AA491862, AA713891, AI687343, AA491650, AI584186, AA468456, AA757775, AW438643, AL036037, AA577959, AI873990, AA568869, AA515334, AA668807, AA508359, AI872020, AW023990, AA643455, AI282511, AA658362, AA724333, H73082, AI538870, AW073060, AA908687, AA487621, AA493621, AA620467, AI471887, AI368256, AI240168, AI345157, AL038705, AA683238, AI568678, H71429, AA662225, AA470969, AI797903, AA488746, AA719292, AA846952, AA804925, AW084466, F27407, AA837791, AI589461, AA747594, AI933299, AI564454, AI924872, AA572713, AI708139, AA490183, AA019312, AI583283, AI054343, AL042547, AW274349, AA811153, AA446544, F17555, AA368059, AW050498, AI338350, AA478355, AA773472, AA634889, AA502155, AA665021, AI247199, AI559251, R02632, AA484373, AW050734, AW235497, R40056, AW193265, AW273218, AW021207, AI472222, AA633753, AW408047, AW303196, AI350211, AW301809, AA668639, AA584581, AA573725, AW247819, AI669453, AA805846, T06754, 109071, AA623002, AW104030, AA806796, AA773902, AA577906, AI625647, AA515909, AI521679, AW302903, AA483223, AI801600, AA581903, AW075948, AI692808, AA503600, AI284640, AI589230, AI744995, AI860013, AW407578, AA629874, AW327868, AI702314, AA181823, AA704009, AA189117, AA743716, AL135377, AL044858, AI859742, AA179944, AI110844, AI110770, AW300625, AI754658, AL119984, AI354388, AI285576, AI873852, AI903462, AA487417, N64587, AW131155, AW301350, AA578861, AA493708, AW196064, AI241821, AL119166, T74382, AI807762, AI381253, AA828767, AI656840, AA501615, AA758366, AL078634, U82671, AP000569, AP000301, AC006255, AP000114, AP000045, AC005668, AG007556, AC007878, AC005191, AF085954, AC005089, AC005261, AL133276, U67827, X75335, AC006571, Z68278, AF039906, AL022320, AL049758, AC007286, AC012599, AC004230, AC002310, AC005385, U62317, Z97053, AC004112, AL022316, AC010200, AC002091, AL031283, AF107885, AC005284, AC005406, Z84484, AL049776, Z98949, AC005295, AL078603, L29074, AL049853, AC005296, U67825, X55929, M22900, AC004076, AL050348, AL049736, AL022725, AB0 14079, AD000833, AL121778, U29953, Z82245, Z69713, AF002993, Z92845, AL133494, AC005306, U76377, Z92846, AC006139, AC002384, AL022311, AF104455, AC007033, AP000339, AF157623, AP000326, AL008728, AC004389, AF038458, AF095725, AP000054, AP000169, AP000123, AP000495, AP000122, AP000217, AL022717, AC005162, AC004991, AP000345, AC003686, AC004842, AC004150, AC004466, AF196972, AL035696, AP000689, AL031588, AL049557, AC005589, AL049697, Z85986, AP000346, AC005837, AL022721, AC006529, AC009399, AC005028, AC004554, AP000493, AC005071, AC005332, AC006042, X55931, AC011625, AL049545, D63507, AF067122, AC003108, AC005765, AC007792, AC000070, AC005514, AC005920, AC007297, AC006312, AC002316, AC004161, U95739, AL023575, Z95113, AL110502, AC006538, AP000517, AC007567, AL021977, D83989, U18390, X55932, AC003029, AL109799, AC005193, AC002119, AL049759, AL035252, Z22650, D83737, AC004615, AC007364, AF001298, AB003151, Z69666, U75285, AC005745, AL022168, Z54146, AP000298, AC004693, Z68869, AB023052, Z69838, Z54334, AF015723, Z97634, Z82976, AC007787, AC006138, AC004152, AC004678, AC004490, AC005790, AC008975, AF006752, AC004036, AC005620, AC002314, AF039907, AC002984, AC005175, AC004205, AC007565, AC004210, AC007229, AL049856, AP000401, AC003960, AC005781, AC005619, AL080242, AP000261, AL031273, AC006388, AC006561, AC005072, AF146367, AC002390, AC004455, AC004650, AC004901, AC004024, Z99569, AL096794, AC004149, Z97988, Z97196, AC002559, AP000246, AL024474, AF190465, AL008710, AL031594, AL022240, AP000035, AP000044, AP000112, AP000513, AP000100, AP000159, AP000017, AP000508, AC004522, AL050341, Z99916, AC006004, AC002115, AC004584, AL009051, AF124523, AC006037, AC004226, AL050401, AC007242, AL049699, AC006539, AC002468, AC005532, AC010209, AC004815, AC006458, AC003982, AC005996, AC005045, AL031295, AC005247, AC006019, AC004933, Z97056, AL034561, AC005244, AL078624, AF118808, AF207550, AC007228, and AC004883. HBGFA62 40 954306 1-628 15-642 AI479262, AW082836, AA877924, AA513292, AA700228, AI244885, AL041763, AI345227, AW275318, D25718, AW001271, AI902419, AA687630, AI349742, AI306060, AI309420, AI307478, AI343141, AW075033, AI266766, AI371550, and AW075142. HBGMD05 41 870189 1-575 15-589 AW393804, AW001436, W42981, AI766185, AA706041, AI365102, AI380655, AW290901, and AI126989. HBGMD62 42 933763 1-315 15-329 Z98258. HBGMF10 43 966132 1-555 15-569 AA532449, AA043318, AI872402, AI524324, AA527086, AA514662, AA659799, AA971274, AA470758, AA602448, AI022054, AA861977, AI636322, AI865691, AI209021, AI055999, AA640580, AA053310, T52958, AI313402, AA058606, AW166625, AW004703, AI348693, AA436104, T61144, T52957, AL696664, AA043317, AW449638, AA129864, AI499456, AI972817, AI424348, AI918494, and AA436005. HBGMG29 44 845194 1-328 15-342 HBGMZ39 45 947112 1-588 15-602 AI820661, AI79 1493, AA989356, AI791282, AI732537, AI792053, AW207804, R22360, R72427, AA505927, R22019, and R72474. HBGNA08 46 958257 1-223 15-237 HBGND09 47 848219 1-1164 15-1178 AA781868, AW152318, AA482996, AA909463, AA758672, and AF156271. HBGNJ14 48 914594 1-317 15-331 AC004156. HBGNM13 49 912730 1-348 15-362 AW177440, C14389, T03269, AI905856, AW352117, AW179328, AW360811, AW178893, AW366296, AW375405, D58283, AW378532, D59859, D80022, C14331, D80166, D80195, AW177501, D80193, D59927, D59467, D51423, D59619, AW177511, D80210, D51799, D80391, D80164, D59275, D80240, D80253, D80043, D59787, D80227, D59502, D81030, D80212, D80196, D80188, D80219, C14014, AW176467, C15076, D80038, D80269, D59610, D57483, D80366, AA305409, C14429, D51022, D50979, D50995, D59889, AW178762, D80024, AW377671, D80378, AW178775, AW360844, D80045, AW360817, AA305578, D51060, AW375406, AW378534, AW179332, AW377672, AW179023, AW178905, D80134, D81026, D51097, AW352170, AW352158, AW352171, AW377676, AW177731, AW178907, AW178906, D80248, AW179019, AW179024, D80522, AA514186, AA514188, C75259, D80133, AW177505, AW179020, D58253, AW178909, AW177456, D80251, AW179329, AW178980, AW177733, AW378528, AW178908, AW178754, AW179018, D80132, AW367967, D80268, AW179004, D80302, AW178914, AW178911, D80439, D80247, AW178774, AW352174, T48593, AW177723, AW178983, D51103, AW367950, AW178986, AI535850, D45260, X82626, A84916, A67220, D89785, A62300, A62298, Y17188, A78862, D34614, D26022, D88547, AJ132110, AR018138, X67155, A25909, AR025207, AB028859, AR008278, Y12724, AF058696, AB012117, A94995, AR008443, A85396, AR066482, I18367, A44171, A85477, I19525, A86792, I50126, I50132, I50128, I50133, X93549, AR066488, D88507, A82595, AR066490, AR016514, D13509, D50010, AR060138, A45456, A26615, AR052274, Y09669, AR060385, AB002449, AR066487, A43192, A43190, AR038669, A30438, AR008408, U79457, AR060133, AF135125, and AR008382. HBGNO07 50 952212 1-369 15-383 AA488707, AA129219, H49568, AI345366, AI310873, AA476397, AA535216, AA086368, AI268334, AI268336, AW021583, AI500453, AA420998, AA421078, AA657835, AL041345, T11634, AA601327, AA431949, AI762314, AA676971, AW157005, AA346367, AI537041, AW008450, AA600869, AA346368, AI051037, AA493621, AA527209, AA186329, AA533281, AA186367, AA579367, AA683238, AA418861, AI884383, AA744018, AA776899, N23392, AL038736, AA478716, N29455, AI702314, AW276835, AA833896, AA833875, AA484373, H56430, AI028510, AA992126, AA579208, AW189384, H49091, AI469599, AA522642, AI590580, AL031710, AC007617, D32060, AC004859, AC008372, AL079340, U52112, AL022311, AC002364, Z74739, AC005089, AL023575, AL031779, AL033522, AL035086, AC011331, Z93783, Z82249, AL022237, AL049643, AD000684, AC002128, AL080242, AC000056, AL022150, AL049538, AC005800, AL109657, AC002565, AL022312, AC007242, AP001054, AL031296, AL024498, AC002312, AC005189, AC004032, AF048729, AC007787, AC004017, AC007999, AL022320, U78027, AC004548, AC005091, AC005833, AL035422, AC000029, AC0075 10, AC006013, AL121769, AL022165, AC004887, AC007055, AC009498, U47621, AC006166, AB023051, AC004099, AC005027, AP000512, AL031466, U89337, Z95113, AF129756, AB007944, AC004699, Z97054, AC005066, AP000505, AC002997, AC002511, AC006057, AC005254, AP000348, AC005619, AP000220, AP000159, AP000084, AC005095, AL031846, AL078593, AL133485, AC006316, AC004033, Z97053, AC002465, AC005609, AC007879, AC005011, AC006064, AC005237, AC005234, AC005158, AL022330, Z99716, AL109984, U73635, U07561, AC004462, AC003072, AC004030, AC002984, AC005387, AL121934, AF184110, AL109952, AC004656, AC005219, AC004771, AL031594, Z98048, AC003688, AC008103, AL008715, AC003103, AC007326, AC006597, AF128525, Z93023, AL021155, L77570, AL050310, AL031005, AC004408, AC002996, AC004796, AC003964, AC005608, Z84480, AC003982, AL022326, AB023049, AL031295, AC004822, AC007845, AC005738, AL021528, AL133245, AL121653, AL049636, AC005880, AC004984, AC005399, AC005666, AC004832, AC005220, AC005411, AL031120, AC007325, AC016025, AC004805, AC006059, Z98050, AC016026, AL135744, AL109865, AC007156, AC005323, and Z95114. HBGNQ31 51 887152 1-355 15-369 AI097455, AW073155, AI690321, AA283204, AI739096, and AI968607. HBGNW29 52 969396 1-421 15-435 AI809990. HBGOB07 53 883111 1-465 15-479 R15924, AI796491, AI346263, AA767342, AW173117, AW148990, AA860973, AI014603, AI640629, AI658566, AA506436, AI368262, AA768887, AI500714, AI355779, AI458779, AI811626, AW081866, AA761573, AI683292, AI472126, S69381, AL008706, AF106657, and T66550. HBGOJ28 54 967261 1-585 15-599 AW406518, R27278, W05444, W87344, AI159814, N56542, W87345, AA053475, AI905956, T53519, AW004657, AI743733, AA468421, AW001343, AA860298, and AA578670. HBGOK53 55 848156 1-621 15-635 AI459692, AW150902, AA781854, AI823723, and AC006255. HBGOL08 56 958290 1-449 15-463 AA113287, D29499, AW294903, AW298373, AW297351, AW294452, Z40314, AI623657, D29192, and AI143487. HBGPE04 57 926876 1-480 15-494 Z98049. HBGPH02 58 918513 1-508 15-522 AI167166, AI034322, AA084622, AA457685, AI246080, AA448838, AI754291, AW243793, AI285521, AI816537, H55894, AC003037, Z97054, AC005913, AC006077, AL023879, AC003007, AC004953, AC005632, AP000356, AL049776, AC003108, AL035086, AF134471, AC002126, AC016027, AL022323, AC006312, AL133448, AJ003147, AC020663, AC005908, AL031295, AC005972, AC003051, AC016830, AC007845, AL096701, AC009509, AC006040, AC002432, AC006211, AC008126, AF196779, AC006538, AL096791, AC007686, AC002470, AC009516, AL008718, AC016025, AC005071, AC007308, AP000555, AL139054, AC005971, AP000501, AC006536, AL135744, AC003 109, AC002365, AC004257, AC003029, AC006254, AC002351, AC004148, AC005015, AL080243, AC005412, AF207550, AC005057, AC003104, L78810, AC006111, AL133249, AL031662, AL022165, AL121655, AL035415, AF067844, AC008044, AL031432, AC007216, AC005778, AC008372, AC003110, AC004167, AC005696, AL049692, AL021453, AC009464, AC007011, AL022326, AC007285, AC012627, AF031078, AL023807, AC000068, AL024498, U95740, AF111169, AF030876, AC005409, AC000134, AL035455, AL022476, AL022316, AC007363, AL034548, AC004990, AC011311, AC005841, AB023049, AC006468, AC004813, AP000512, AC005529, AC004024, AL024507, AL033527, AL022163, AL034549, AC004883, AC004448, AL117344, AC003101, AC007240, AC005920, AP000503, AC007688, AL031311, AC004821, AC005411, AC005519, AC002456, AL133163, AC002312, AC004859, AF091512, AC007488, AC005488, AL031255, AC005940, AC004934, Z82215, AC005484, AC005081, U78027, AC010206, AL133245, AL008582, Z93023, AC006511, AC006285, AL132712, AC002531, AC005666, AC004019, AC006965, and Z95114. HBGPK33 59 973425 1-696 15-710 HBGPV05 60 930706 1-607 15-621 HBGQG66 61 954302 1-356 15-370 HBG5D40 62 923142 1-526 15-540 AI554033, AW072396, AI391722, AI703323, AI278195, AI681504, AW015130, AI378014, AI869650, AA028102, AW341627, AI674186, AA253036, AA918302, AI242366, H27749, R52130, AI203836, AA253072, AI473245, H18391, H29918, H45059, H46854, H46789, H18178, H18179, H46768, H45025, AA028123, H29829, H46718, and H18392. HBGTK11 63 965509 1-261 15-275 HBGTL01 64 914573 1-636 15-650 AI333621, AI655982, AI635579, AW014176, AI365145, AA758176, and Z97986. HBGTR84 65 886529 1-753 15-767 HBNAB01 66 966536 1-126 15-140 AI865067, AW272770, Z28887, R71650, H97886, AA564346, H68773, H59762, AA025159, AA025578, AA129730, AA167746, AA416665, AI359427, AA908506, AA554889, AI040310, AA890292, AW085815, AA292680, AI192586, AI672645, AI086456, AI086880, AI289899, AA524469, AA708866, AA630222, AI435170, AI192590, AI027640, AA541738, AI660871, AI346559, AI970609, AA873432, AA815359, AI300157, AI300558, AI346676, AW044620, AI982695, AI986013, N23343, AA872691, AA741346, AA873873, AA777182, AA857133, AA676868, N53944, H80871, N53661, R31880, H51417, R85259, AA775814, R31095, AA906957, H57155, N93620, H02122, AA659321, AW020777, N28815, AA417245, AI422162, H96301, H51459, AA025977, AA133344, H23915, and AF129332. HBNAF14 67 660800 1-267 15-281 HBNAI71 68 655514 1-321 15-335 HBNAN41 69 655842 1-299 15-313 HBNAW92 70 524954 1-274 15-288 AF107885. HBNAX71 71 530843 1-73 15-87 HBNAY58 72 558193 1-492 15-506 T47565. HBNBT52 73 524869 1-366 15-380 HBZAJ09 74 655769 1-329 15-343 HBZSH16 75 655619 1-384 15-398 HBZSH71 76 760418 1-288 15-302 AI339869, AA669158, AI589895, AI055909, AW131819, AA994746, AI055952, AW072134, AA504384, AA588867, AA558699, and AA504125. HBZSI73 77 655737 1-339 15-353 HBZSK17 78 664013 1-369 15-383 AA300051, AA317019, AA086322,AA147482, AA112027, AI903350, AI903380, AI903419, R48705, AC005005, AF115565, Y13492, AJ010306, AF064238, and Z49989. HCBMV01 79 914333 1-310 15-324 AI493588, AL134598, AA928539, AI500061, AI440260, AI539690, AW300782, AW300889, AW089844, AA641818, N22276, AI335235, W48671, AL046926, AI766348, AI587114, AI114703, AI473536, AW020046, AI631240, AL118752, AI349279, AW020419, AI702065, AW075382, AI251221, AI687130, AL047422, AL038605, AW022102, AI539260, AW020693, AI590043, AI336513, AI969655, AI307569, AL048323, AI348895, AI307494, AL047172, AI336495, AI335476, AI335363, AI815855, AL048340, AI340627, AI334450, AA555145, AW021662, AI348854, AI344935, AI334895, AI866465, AI865116, AI349245, AI559752, AI538850, AI499570, AI310930, AI446721, AI567971, AA503384, AI401697, AI538564, AL118781, AI312261, AI349958, AL046200, AL047344, AI349814, AI638644, H41759, AI336503, AI866646, AW020397, AW301861, AI267185, AI345005, H92687, AI553645, N25033, AL047655, AW023338, AI349186, AI538764, AI784233, AI340511, AA808175, AW059828, AI866503, AI345014, AW022494, AW020288, AI584118, AW162189, AA420722, AW020095, AI624543, AL046227, AW021717, AI345527, AI345745, AL120756, AI538885, AI340552, AI690411, AI579901, AI345736, AI345131, AL047100, AI758583, AA502794, AW086082, AA659314, AI307736, AI335208, AI581033, AW020710, AL042745, F28295, N29277, AI633125, AI366959, AA635382, AA176980, AI815232, AI868475, AI572096, AL045413, AI500714, AI343030, N67350, AI538008, AI471909, AI567883, AI312210, AI923989, AI284517, AI560545, AI627714, AI619820, AW059766, AI207656, AI611728, AW151138, AI241678, AI634736, AI348969, AW022636, AI927233, AA062896, AA042949, AI340603, AI801325, AI537273, AI682934, AI371251, AW152182, AI702527, AI472487, AI436429, AI859991, N81164, AI564716, AL079963, AI690472, AL036705, AI500662, AI624304, AI366992, T99953, AI698391, AW079768, AI868180, AI784214, AI800367, AB029065, AF061573, X72889, A15345, AF026816, AL080124, X81464, D44497, AL049382, and AF069506. HCBNW02 80 950897 1-508 15-522 HCBNW07 81 951820 1-415 15-429 AI419479, AI084317, AW072920, AI350149, AA847656, AA931572, AI423647, AI983432, AI056162, AA826926, AI478982, T50766, C00534, and AC005803. HCBOG03 82 922351 1-469 15-483 HCDMB01 83 915613 1-430 15-444 AL042428. HCDMB16 84 835781 1-261 15-275 HCDMB60 85 726339 1-107 15-121 AI590413, AI869343, AI955933, AA593639, AI886450, AA576909, AI371486, AI971730, AA602301, AI421322, AI383426, AI371487, AW059533, AA858249, C00365, Z41784, F17104, AI200274, AW166558, AW337598, AA232052, AA280665, AA731352, AA729138, AW206613, AW241202, M62039, AI932508, AA769242, AI865740, AI866738, AI858186, H12707, AA434237, AI863089, AI874192, N22963, AI349363, AI161110, AA622939, AI625498, AA280821, AW264859, AW198004, AI689114, AI298884, AI311832, W93266, AW152359, AA905965, AA280666, AA044299, H20483, AW273322, AW117633, AA872094, AI811143, AW268474, AA838719, AI858578, AW303327, AW081605, N63438, AI744276, AI992061, AA603101, AI189379, T78004, H62603, AW291643, R72899, H53116, AW193894, H52807, H42028, AI521005, AA745254, AI819014, AI624624, AI859693, AI613489, AI473536, AI696603, AI284013, T69241, AA831128, AI818562, AI674627, AA102339, AL042193, AF106657, AF184965, AL137488, AF060866, X69026, A58545, AL137284, AF076633, AC010077, AL137657, AL080154, AL050155, AL137480, and AJ005690. HCDMC01 86 915239 1-1444 15-1458 AI201296, AA421493, AI015515, AA401557, AA693498, AA815294, AA609724, AA608961, AA705839, AI016248, AA400144, AA971327, AI656796, AA383127, AA725026, AA815293, AA609137, AA421507, AI024165, and AC005789. HCDMD23 87 676799 1-171 15-185 HCHAD40 88 923764 1-337 15-351 AL039087, AL037259, A91754, A49700, AR031375, A58521, AR020969, A44171, I56772, I95540, A63067, A51047, A63064, A63072, AR068507, AR068506, AR031374, AR018924, AR000006, AR015960, AR000007, AR015961, AR051651, A94046, A94054, I58322, I58323, A38214, A49701, E12566, E12564, E12565, AI8051, I01012, E02455, AR067785, A00782, AI4595, AI8755, I12245, A92666, A25856, A92668, A92667, AI8050, A02741, I77211, AR007512, A80476, A80477, I56770, I56771, I25041, AR027319, A91752, A91751, AR027318, A95274, Z73334, A06633, AR029417, I58669, I85513, AR067733, AR027100, AR009152, AR009151, AR027099, I07209, I07249, A63954, A93445, I25027, I26929, I44515, I26928, I26930, I26927, I44516, Z96177, A93936, AR067731, AR067732, A60206, AR035224, A49045, A27169, X85060, AR016495, AR029418, I91969, A60212, A60209, A60210, A60211, A93446, I09267, I09270, I09268, I09269, I09252, I09251, A27170, A39929, A83151, A95117, AR068508, AR068510, AR068509, AR054109, A48774, A29109, A32111, AR068550, A23373, AR068551, A48775, E01324, I08638, A94048, A94061, A70359, AR003585, AR038066, A83180, AR038321, AR038307, AR051652, A32110, X89399, AR067734, A64973, A83642, A83643, AR038320, AR038306, Z73920, E01239, E01561, AR064436, A92081, A92080, A92077, A92078, A92079, E01619, Z96705, I06159, E16475, AR055048, AR055051, AR055049, and AR0 I2640. HCHAR16 89 675465 1-216 15-230 AA594128, AI625342, AW057569, and AA808529. HCHAR43 90 715128 1-446 15-460 AA459445, C18242, AC003036, and Y12781. HCHAR67 91 665184 1-306 15-320 AI816095, AW402653, AA827700, AW449023, and AW444910. HCHBQ03 92 923763 1-490 15-504 AL039087, AL037259, A91754, A49700, AR031375, A58521, AR020969, A44171, I56772, I95540, A63067, A51047, A63064, A63072, AR068507, AR068506, AR000006, AR015960, AR031374, AR018924, AR000007, AR015961, AR051651, A94046, A94054, I58322, I58323, E12566, E12564, E12565, AI8051, I01012, E02455, AR067785, A00782, AI4595, AI8755, I12245, A92666, A92668, A92667, AI8050, I77211, AR007512, A80476, A80477, A02741, I25041, AR027319, A91752, A91751, AR027318, I56770, I56771, A25856, A92665, A38214, Z73334, E16475, Z73920, A49701, A95274, Z96705, A00223, A00224, I70974, A80474, A31896, 163070, 163071, 163072, AR066336, I21924, I44104, I44103, A06633, I85513, I46976, AR067733, AR027100, I58669, I25027, I26929, I44515, I26928, I26930, I26927, I44516, AR009152, AR009151, AR027099, I07209, 107249, A63954, AR029417, Z96177, A93936, AR067731, AR067732, A60206, AR035224, A49045, A27169, X85060, AR016495, AR029418, A93446, I91969, A60212, A60209, A60210, A60211, I09267, I09270, I09268, I09269, I09252, I09251, A27170, A39929, A83151, A95117, AR068508, AR068510, AR068509, AR054109, A48774, A29109, A32111, AR068550, A23373, AR068551, A48775, E01324, I08638, A94048, A94061, A70359, AR003585, AR038066, A83180, AR038321, AR038307, AR051652, X89399, AR067734, A64973, A83642, A83643, AR038320, AR038306, A32110, A93445, AR038762, E01239, E01561, AR064436, A92081, A92080, A92077, A92078, A92079, E01619, 106159, AR055048, AR055051, AR012640, and AR055049. HCHML32 93 668518 1-535 15-549 Z59318. HCHND96 94 880585 1-592 15-606 AA872500, AI026825, AI023522, AA769674, AA446298, AA446025, AA435968, AA719152, AI826656, AA928442, AL043981, AA300900, AL043982, AA948304, AA961187, D45701, N71729, AI557254, N71226, C14208, AI525796, AI541218, AI557264, D51378, AI535873, and A84916. HCHOA76 95 740102 1-488 15-502 AI963720, AW193265, AL046409, AI305766, AI345654, AA490183, AI431303, AA581903, AI284640, AI613280, AI281881, AA610491, AL042853, AW303196, AW274349, AI696962, AI355206, AW301350, AL138265, AI334443, AI270117, AI350211, F36273, AW419262, AI799642, AI570261, AW062724, AW407632, AI679782, AI754658, AA584201, AI801482, AL046205, AI192631, AI421841, AI589230, AW408717, AL138455, AI537506, AI890918, AW438643, AA649642, AI133164, AL037683, AL041690, AW406755, AL119691, AA482711, AA720702, AW029038, AW238278, AW276827, AI061334, AI962050, AI064864, A1110770, AI624142, AI634384, AW023672, AW270270, AI358229, AL118991, AW304584, AL044940, AI345681, AI345675, AI866856, AW083402, AA569471, AA587604, R24205, AI365988, AW407578, AW162049, AI929531, AI270559, AI623720, AI289067, AL042420, AI754253, AI341664, AW410400, AI890348, AW265393, AW073470, AI471481, AI339850, AI917271, AA523815, AA551503, AI696955, AI469968, AI956131, AA491814, AI625244, AL047427, AL120269, AI732865, AI076616, AL048626, AI357901, AA857486, AA623002, AI890923, AI254615, AI344844, AA469451, AI610607, AI610920, AW088202, AW265385, AI457397, AI887483, AA521323, AW249224, AI888518, AW193432, AI341548, AI368256, C75026, AA468022, AI801600, AW265009, AI538433, AA661948, AA665330, AI619997, AI149478, AI688846, N53150, AW103509, AI005388, AI133102, AL048925, C06327, AI305547, AI249997, AW261871, AI792287, AA613227, AI368745, AI375710, F28204, AI904894, AI859742, AI567674, AA877817, AI053623, AI679132, AI473943, AW088616, H71429, AL038785, AA630362, N48230, AA631507, H90814, AW166815, AA164251, AA177061, AA521399, AI885572, AI918421, AW272758, AI340453, C05755, AW080134, AA713815, AA552856, AL038606, AA679514, F29989, AI358501, AI732764, AA613345, AI345518, AA491284, AA610493, AI144055, AA846935, AA394271, AW072587, AI053672, AW440836, AW265170, AI628288, AA828704, AA503258, AI744995, AI307608, AI471534, AI687343, AI291124, AW439558, AI708009, AA525790, AW339687, AI110760, AI376100, AI683577, AI921649, AW104748, AA594145, AI568678, AI860020, AW243960, AA503015, AI251436, AI469624, AW072923, AI471543, AW270716, AW242109, AL079645, AA350859, AI267818, AL119649, AA826303, AA584489, AI623898, AI085719, AW270382, AA134367, AW238583, AL109985, AC005234, AF015152, I51997, AF077058, AF015147, X55925, AF015148, I248391, AC004687, X53550, AF015149, I257007, D83989, X75335, AC005844, AC004257, I257006, AF015156, U18395, U02531, I218392, U57009, I218394, I257005, AF015153, U18390, AF015151, U57008, I218393, AP000556, AF015157, AC004491, X55926, X54180, I218387, X55924, AC002470, AC004134, AC005280, U02532, I269569, X54175, X54181, X54178, X55931, AL035587, Z98200, AC007367, AC007308, AL031295, AC007785, AC016830, X54176, X55922, M37551, AC004596, AP000143, 1257004, X54179, AC008101, AC006998, AC005257, AL121653, AL024497, AC004263, U67801, AC002456, AC006213, AL008629, AL132642, AC004876, AL031276, AC004773, AF015167, Z49816, X55923, AC007637, AL031729, AC005484, AL121825, AC002128, I218400, AB023049, AC005755, AC008079, AF042090, AL035071, AP000557, AL021366, X54177, Z22650, AC004675, AC004475, AC007450, AC005011, AF196779, AC005015, U91321, AL050332, AC005180, AF085913, U67221, AL049776, AP000090, AL035451, AF088219, AC003957, AL021808, AL031848, AC009223, AC008119, AL022322, AC006274, AL132992, AL096712, AL031005, Z83819, AL031681, AL021393, L47228, U07000, L48038, AP000302, U47924, D87675, AC005971, AC005682, AC005360, AF015155, U12580, AL035415, AC005747, AC004752, U12584, AL109798, AC009516, AL035446, AC002059, AC005696, U18399, AC004947, AC005520, Z99758, AC004682, AC007043, Z83840, U73479, AC006352, X55927, AF015166, AL031542, AC008039, AC006511, U67229, AB023052, Z93023, AL031123, AC003043, AC002543, AF109907, AC006449, AC004941, Z93930, AP000114, AP000046, AP000359, AF015154, AC004526, AL022724, AL031965, AF107885, AC002041, AP000553, AL133233, AP001172, AD000684, AP000348, AC004987, AL035079, AC000026, U95740, AC005379, AC006479, AF111170, AC005081, AC004087, AC004858, AL132987, U67231, AL023882, AL121603, S75201, AC005324, AP000513, AL022323, AL021918, AC005193, Z97053, AJ003147, AC005610, AC000075, AF015162, S43650, AF015155, U62317, AC002094, AC006071, AC006128, X55930, AC004041, AL021939, AL078477, AC002549, AC004092, AC005681, AC006211, AC003024, AL022332, Z99129, AC006468, AJ010395, AC002350, AP000161, AC004796, X55932, AL023575, AF045555, AC005057, AC004862, AC007688, AL031224, AC005664, Z73988, AP000512, AC003684, AC022517, AC009069, AL049562, AC005632, AC004111, AL050347, U62293, AL117352, AC006138, AD000092, Z86061, AL022311, AL008720, and U18398. HCHOD89 96 954866 1-202 15-216 HCHPO55 97 717671 1-116 15-130 HCHQB06 98 934941 1-490 15-504 AI569831, AI798887, AI209013, and AW300115. HCMSE07 99 927904 1-1366 15-1380 AI681115, AI672348, AW173697, AI565451, AL079990, AW305215, AA115462, AA148788, AW081450, AW020072, AI088661, AI051834, AA243692, AA031780, N44611, AI610893, AI469307, AI094153, AA115214, AW130820, AI970462, AA233114, AI620951, N34679, AA115204, N69772, AA495921, AA987696, AA495922, AI079994, AI050072, AI434100, AW236674, AI770044, AA961227, AA115067, AA150297, AI039432, AI873440, AA938897, AI301357, AA603790, AA326653, AA910225, AA031879, AA377521, AI702644, AI913596, AA961701, AW452143, AI352693, AI381836, AI767254, AI247300, AA573940, AA081742, AI830541, AI493755, AI865675, R37287, AA937056, AI648373, AA653705, AI266405, AW138034, Z41281, N85358, AI090946, N84377, AI612953, F08269, AI572322, T49708, AW103627, AA364595, D25919, T49717, T49709, AA094410, AA385800, AP000300, AP000113, and AP000045. HCOMZ41 100 932878 1-347 15-361 AA863389, AI695443, AI969882, AC006512, U47924, and AA863395. HCOOG04 101 925748 1-104 15-118 AI922923. HCOOI07 102 951665 1-710 15-724 HCOOM77 103 969161 1-502 15-516 HCOOX10 104 961595 1-556 15-570 AI913553, AI418464, AA299849, AA729782, AI547277, AC005005, and AC000403. HCOOZ11 105 965306 1-689 15-703 AI350354, AI904299, AI902503, D61534, T78554, AW183962, AI218626, AW304978, W74167, AI081779, AL022238, and AL137499. HCOPP18 106 954332 1-651 15-665 T63995, and AI669879. HCOQE11 107 965299 1-825 15-839 AI554514, AW117613, AA401269, AA894442, AI923609, AA968468, AA779787, W56250, AI049682, AI342711, AI277156, AA424469, AA443257, AW023482, AI978942, AI611714, AL132777, and AB024689. HCOQH12 108 969151 1-551 15-565 AA683227, H65257, Z99396, AW392670, AW372827, AL119497, AL134531, U46341, AW384394, AL119457, AL119483, AL119418, AL119324, AL119522, AL119319, AW363220, AL119396, AL038837, AL119484, AL119391, U46350, AL119341, AL119443, U46349, AL037051, AL036725, U46351, AL119335, AL119363, AL119355, AL119496, AL036418, AA631969, U46347, AL043029, AL042989, AL119401, AL134920, AL134533, AL036924, AL042970, AL119488, AL119439, AL042965, AL134528, AI142139, AL042975, AL043033, AL119444, AL043011, AL037205, AL042614, AL036858, AL134538, AL042984, AL042544, AL042542, AL043019, U46346, AL043003, AL043037, AL042551, AL042896, AL042850, AL042995, U46345, AL037094, AL036268, AL036190, AL037639, AL036196, AL037526, AL037085, AL036998, AL037082, AL038447, AL037615, AL036733, AR066494, AR060234, A81671, AR023813, AB026436, AR064707, AR069079, and AR054110. HCOQQ07 109 951658 1-424 15-438 HE8SG46 110 961388 1-2631 15-2645 AI678080, AW118890, AI962969, AI936455, AL037402, AA969064, AI127304, AI677882, AW195711, H19013, N33206, AI127565, AI332958, AI089991, AI253076, AW051831, AI025225, AI004194, AI873265, AW182432, N48995, AA528395, AI290549, AI003987, AA022465, AI377431, H81787, AA225942, N44742, H19307, W25684, AI246674, N95594, H81786, Z42919, R52370, H98158, AI382954, Z43457, AI244671, AI093458, AI042622, R52369, R73912, W20350, Z39530, AA022998, C04474, W92421, R74008, F02397, N92731, AA934795, AA502534, AW081759, H98461, AA744985, AA883984, AA319261, AI619688, AL079491, N45717, and AA662787. HEAAA42 111 963100 1-260 15-274 AL043767, AA043579, and H42377. HEAAB77 112 574510 1-348 15-362 AW452627, and AC009248. HEAAK46 113 574232 1-259 15-273 AI910578. HEAAM16 114 574008 1-338 15-352 HEAAM52 115 960579 1-427 15-441 HEAAN18 116 932383 1-251 15-265 HEAAQ66 117 653242 1-389 15-403 HEAAT36 118 531348 1-476 15-490 R90939, H66735, and R89394. HEAAT60 119 733632 1-459 15-473 AL137566. HBAAV10 120 968200 1-347 15-361 AL031178. HEAAV33 121 574508 1-436 15-450 W79572, HEDAE67 122 752875 1-133 15-147 HEEAD64 123 741305 1-328 15-342 AI041541, and AC006116. HEEAH07 124 851219 1-329 15-343 AI343204, R92902, AW138732, AC011331, AL137469, AB007899, Z84480, AP000228, AP000140, U95090, AP000078, AL050067, AC010168, AC004741, AC002426, AC005668, AL022164, AC005034, AD000685, AL035701, AC005307, AC005067, AC005572, AC003663, AC007056, AF099810, AC004472, AF061779, AL022399, AC000025, AC005527, AL022238, AC005529, AC005280, AP000088, AC007298, AC004964, AC002991, AL021026, AC002287, AF181449, AL008725, AL118516, AC006271, Z94044, and AL031985. HEEAJ58 125 785121 1-340 15-354 AA206618, AA204795, W38480, AA431939, AA587180, and AF080470. HEEAJ76 126 887321 1-535 15-549 AW088322, D80133, D80522, D80248, D80251, C14389, D51060, D81026, D59610, D51022, D80366, D80188, D59859, D51423, D80166, D59619, D80210, D51799, D80240, D58283, D80253, D80241, D81030, D80269, D50979, D80024, D80212, D80195, D80043, D80022, C14331, D80219, AW377671, D50995, D59467, D80391, D80164, D59275, D59787, D80227, D59502, D57483, D59889, D80196, AA305409, AA305578, D59927, C15076, D80038, D80193, C06015, D80045, C14014, D80378, D80268, D59373, AW177440, AA514186, AA514188, D80439, C14429, AW360811, AW178893, D80302, D59627, D80247, C75259, AW178983, T03269, AW375405, AW179328, AW378532, D80258, C05695, AW366296, AW360844, D58253, AW360817, D80132, AW375406, AW378534, AW178906, D51759, AW179332, AW177501, AW377672, AW179023, D80157, AW178905, AW177511, D80134, D51103, AW178762, AW378528, D51250, T11417, AW176467, AW352171, AW377676, AW352170, AW360834, AW177731, AW178775, AW178907, AW369651, AW179019, AW179024, AW367967, AW352158, AW177505, AW360841, AW352117, AW179020, D59653, AW178909, AW177456, AW179329, D59503, AW178980, AW178914, AW177733, AW178908, AW178754, AW179018, T48593, D51213, D81111, D80064, AW378525, D51079, AW179004, AW178774, C14227, D45260, AW179012, AW352120, AW352163, T02974, AI910186, AW352174, AW378543, AW179009, AI905856, H67854, C14407, AW177728, AW178911, AW378540, AW177722, D58246, F13647, D51221, AW367950, H67866, AA514184, C03092, AW177508, AA809122, AW178781, Z21582, D80228, AI525923, AW177497, AI535850, D60010, AI525917, D80014, AI557774, AW178986, D59474, T03116, C14957, C14298, AW177723, AW179011, D59317, AW378533, C14973, D58101, D45273, AW378539, AI525920, C14344, T03048, D50981, AI525235, AI557751, AW177734, D80168, AI525227, AI535959, AI535686, AA285331, D59551, AI525912, D51097, C14046, D60214, AI535961, D52291, AI525215, D80949, AW378542, AI525242, AI525925, AI525222, D59695, C16955, C05763, Z33452, AW360855, H67858, AI525237, D51053, C04682, Z30160, T02868, A62298, AR018138, AR008278, AJ132110, A84916, A62300, AF058696, AB028859, A82595, X67155, Y17188, D26022, A25909, AR060385, Y12724, A67220, D89785, A78862, D34614, AB002449, A94995, D88547, AR008443, I50126, I50132, I50128, I50133, AR066488, X82626, AR016514, AR060138, A45456, A26615, AR052274, AR016808, Y09669, A43192, A43190, AR038669, AR025207, AR066487, A30438, I14842, AR054175, D50010, AR066490, Y17187, I18367, AR008277, AR008281, A63261, A70867, AR008408, AR062872, AR016691, AR016690, U46128, AB012117, D13509, A64136, A68321, AR060133, X68127, I79511, A85396, D88507, AR066482, A44171, A85477, I19525, A86792, X93549, U79457, AF123263, AR032065, and AR008382. HEEAK22 127 673904 1-312 15-326 HEEAK84 128 780838 1-293 15-307 AC004549. HEEAL31 129 887312 1-333 15-347 AL137566. HEEAN24 130 676721 1-335 15-349 HEEAS58 131 735620 1-496 15-510 HBEAU79 132 706935 1-430 15-444 H64999, and AC011311. HEBAW01 133 851213 1-372 15-386 AA368329, AI281622, AA935827, AA581317, AI350189, AW177224, AI859906, AI039257, AA385094, H29593, F35789, AI267450, AI267356, AI245693, AA493533, AI668566, AA364199, AL039515, AW151848, AI733523, AI732911, AI336771, AA614647, AI338575, AA354695, H48017, R70883, AA736713, AI249688, AI982994, AA197089, AA496941, AI671077, AL040360, AA834798, AI038304, AW023975, AA354677, AI003391, AI754567, AI569100, AW192599, AI754105, AI755214, R70884, AA351893, AI080307, F23268, AA813203, AA456149, AA525332, AA557945, AA077637, AA533660, N55076, AW301855, AA504951, AI342863, H65213, AI459879, AW089395, AA155817, AA363311, AI270280, AI624038, H43183, AI905494, AI859744, W61253, AI791227, AL041681, AL041682, AA847341, AA522864, AA601378, AA077247, T10579, AL047645, AA579082, W69639, AA878492, AA132445, AI791659, AW303822, T07013, W28786, AA715508, AA126475, AI690520, AW167202, AI114645, AI370470, AA664924, AI884404, AA678616, AL039761, AW265688, AA653291, AW026282, M78137, AA598605, AI749306, AA524846, H94979, AA809104, AI821945, M77964, AA584525, AI468993, AI285651, AI708108, AI207534, AA449468, AA831801, H96919, F00937, AA745628, AI018726, AA467740, AW265484, AI016192, AA133293, AA825954, AI734119, Z94054, L78833, AC004447, AC008044, AC006210, AL121748, AC005678, AC005537, AC005828, AP000255, AC004158, AL132987, AP000135, U91321, AP000031, U96409, AL133241, AC007371, AC006211, AL049781, Z99291, AL031291, AL031685, AC005527, AC005632, AL137100, AP000558, Z82208, AC005074, AC005412, AC005180, AC002990, AC005529, Z82193, AF002223, AC004383, AC004673, AF095725, AF196969, AC005015, AL023574, AL008718, AJ251973, AC007687, AC005599, AC006121, AP000502, AC006120, AC005695, U91325, AC006487, AL031848, AL035455, AC003108, AL049776, AL049699, AC004417, AL022165, AC005696, AC009516, AF052041, Z69721, AC002492, AL022316, AL035684, AC007686, AL139054, AC003663, AC006511, AC002045, AC004815, AL031053, AC004230,AC006111, AC004834, AF205588, AC004486, AC005089, AC004870, AF217403, Z68331, AC007387, AC004655, AL031657, AC002395, AC005325, AL031287, AC005746, Z93024, AL035588, AC007096, AC004098, AL117338, AC004687, AC002301, AC002288, AP000094, AC005300, AC005231, AC007207, AP000010, AC003037, AP000555, AF030453, AC000049, AC009275, AC008154, AC006071, Y18000, AL035587, AC019014, AC006204, AC004682, AC005808, AC002430, AC005088, AC006948, AF053356, AL020996, AC000111, AC005971, AC005184, AC002302, AP000213, AP000305, AC006312, AL031432, AC005261, AL049760, AC007384, AC004854, Z98051, AC007563, AC005324, AB016897, AL121580, AC005280, AC006079, AC009399, AC007238, AC007676, AL034423, AC005606, AC007435, Z98745, AC004771, D87012, AP000047, Z98742, AL050307, AC007367, AC006023, AP000355, AC004263, AL049780, AC003025, AL096757, AL049872, AL031767, AC005821, AC005751, AC004890, AC005914, AL118497, AC004760, AC005856, AC004900, AL031659, AC002072, AL035706, AC005874, AF134471, Z84497, AC004242, AC004542, AC005694, AC005747, AL031680, AL031311, AC004081, AC006020, AL008630, AF001549, AL031295, AC006017, AL133500, M92069, AF139813, AC005081, AC008282, K03431, AL031984, M69197, AP000115, AP000692, AC004686, AC005544, AP000030, AL020997, AL033527, AC007666, AC007240, AC009028, AF200465, AF196779, AC004004, AC004883, U82668, AC006254, AC002350, AC006088, Z70224, U95742, AC006455, Z97055, AC004762, AF126403, AD000833, AL049591, AP000152, AC004106, AL033397, AL031588, AC006132, AL034553, AC005722, AC004099, AC002299, AL022398, AL009179, AC003013, AC004975, AL049761, AC004228, AC005702, AL109963, AC007277, Z82176, AL021368, Z95115, AC008056, AC005399, AC004882, Z95116, AC007216, AC004812, AC004491, and AC005519. HEEAW13 134 656299 1-357 15-371 AC005344. HEGAA24 135 676716 1-407 15-421 AC005324. HEGAA73 136 767284 1-411 15-425 HEGAB84 137 823900 1-339 15-353 AI222155, and AC007040. HEGAC69 138 754344 1-600 15-614 W21047, and AW364581. HEGAC95 139 965183 1-584 15-598 AW275380, AW273693, AA102550, AI589713, AA515679, AA931215, AA069905, AA661692, AI361672, AI500209, AA025822, AA447097, AI249434, AA833996, AI086891, AA342066, R41926, AI005214, AI376215, AA992138, R37636, AW129954, AA039651, AI986034, AI358677, R39054, AA428629, AI274337, AI352529, AI768472, T78443, AI125818, AA977410, T91051, AI828094, AI675983, AW248442, and AI681656. HEGAI82 140 955291 1-594 15-608 AI624142, AW393412, M62051, AI870044, AA330088, and AB014538. HEGAK04 141 887299 1-502 15-516 AA707670. HEGAO83 142 780837 1-314 15-328 AR064011. HEGAP06 143 934705 1-636 15-650 AI813699, AW051520, AI312608, AI338779, AI369324, AI218925, R72618, R80387, R72688, R80493, AA928026, R63885, AI298652, R63884, and AI214650. HEGAP31 144 697419 1-454 15-468 U73167, and U90094. HEGAP36 145 706951 1-536 15-550 HEGAR53 146 719387 1-669 15-683 H83841, AA019657, and AI127286. HEQAY32 147 699906 1-182 15-196 R55547, H12557, H27260, H00825, R23780, AA747653, H12800, T50030, H42368, and AW361580. HEGAY52 148 726316 1-190 15-204 AL137660. HEGAZ61 149 950033 1-547 15-561 X66139, and X66140. HEPAA44 150 509456 1-313 15-327 AA335025, and AA335496. HEPAB70 151 557149 1-341 15-355 HEPAD09 152 888726 1-268 15-282 AA335537, AA336174, AA335376, AW406878, AI541216, AI525220, AI525710, and AL022318. HEPAD40 153 509002 1-254 15-268 AA335399, and AA335663. HEPAD82 154 509452 1-185 15-199 AA335412, AA335243, AA335606, and AA507007. HEPAJ70 155 586843 1-61 15-75 AA335523, and AA335948. HEPAK01 156 518331 1-297 15-311 AA335526, and AA347833. HEPAK41 157 925146 1-571 15-585 AA524859, AI366999, AW274554, AW085032, AA897153, AA335550, AA405462, and AW305246. HEPAM29 158 508706 1-389 15-403 AA335591, andAA335639. HEPAN19 159 508694 1-395 15-409 AA335593, AI247347, AA335892, AI700468, AI014987, AA629210, AI700878, and X66139. HEPAP02 160 926914 1-351 15-365 T31859, AI452722, AI810976, AA039492, AW166142, T34621, AA887990, AA526699, AI491944, AI291744, AA971270, AI291429, AI147212, AI191377, AI282167, AW194181, AI382209, AI819092, AI125991, AI291350, AA635803, AI076763, AI025483, AW054812, AW026209, AI872247, AA446939, AA393844, AA595299, AA588205, AA635837, AA580350, W42714, AA652370, AI205639, AI346541, AI299347, AA618584, AA041546, AI190326, AI589781, AI038728, AA747482, AI374991, AI186987, AI272049, AA968514, AA781105, AA719399, AI745517, AI479431, AW005070, AI760672, AI828575, AI653887, AI983727, AI950052, AI681964, AA953968, R60201, AW001576, R43919, AI568018, AI445351, R88422, H14119, AI588901, T67080, H20066, Z38557, AA069378, N95318, H19689, R88071, AA069325, AW340398, AA532555, AA742707, AI095816, AI261987, T31864, AA224332, AI089055, AI192912, T29995, AI690936, AA490233, AA425662, AW178914, H52718, AW178908, AI198749, AI277302, AW178907, N75536, AW178911, AI336808, AW178912, AW050516, N91860, AW178906, AI354778, H19688, AI925482, T31898, AA308975, AA393826, H19728, AW439026, AA362297, AA308974, AA427787, AW178913, AA375056, AI028636, AI281040, AI955663, AA350360, AI372759, AA328758, AA223799, W23910, R88070, AA536032, U79457, and AC005041. HEPAP12 161 968771 1-298 15-312 A01447, and E00237. HEPA544 162 884083 1-371 15-385 AA335822, AA335497, AA605142, AA493490, and AC005042. HEPBA39 163 919875 1-696 15-710 AW291560, AA335715, AA897741, and AI559166. HEPBB24 164 508684 1-206 15-220 AA335914, AA335921, and AA335993. HEPBB60 165 855597 1-351 15-365 AA335668, AA336011, AA335983, and AA335973. HEPBG26 166 967921 1-344 15-358 AA336199. HEPBG35 167 508686 1-221 15-235 AA335799, AA336205, and AA653622. HEPBH28 168 508673 1-390 15-404 AI208794, AA336191, AA150459, AI620599, and AC003090. HEPBH38 169 707524 1-325 15-339 AA335435, AI078409, AA384480, AI635196, AI445373, AA515224, AA363957, AA551548, AI793032, AF053356, AF111167, AC006511, AC004106, AP000044, AP000112, AF001549, D00596, AC005531, AL080241, AC002310, AL049694, AC005043, AL049643, AL034421, AC002350, AL022334, AL133243, AC004770, AC009225, AC005231, AC005031, AC004134, AP000475, U80017, AL049569, Z82206, AC004000, AC007358, AC002400, AB002325, AC005618, AC005730, AL049745, AF176815, D88268, AC005632, AC006137, AC002126, AD000812, Z82190, AL035460, AC004223, AC002477, AL050318, AC005071, AC004692, AC004531, AF060568, AC007055, AF015262, AJ229043, AC005261, AL022322, AC004675, AL133245, AC001228, Z93023, AC005529, AL121973, AF134726, AC006965, AC006285, AL008718, Z49236, Z99943, AL035086, and Z93930. HEPBH45 170 508696 1-312 15-326 AA336047, and AA335600. HEPB069 171 888697 1-335 15-349 AA335535, AA335244, AA335394, and AC004464. HEPBQ47 172 713836 1-327 15-341 AA336176, AW204786, AI094626, AW246712, AI935606, and H92959. HEPBQ69 173 888693 1-448 15-462 AA335278. HEPBS10 174 968665 1-391 15-405 HEPBX43 175 715685 1-431 15-445 AI827693. HEPCD36 176 523670 1-285 15-299 AW372642, AI763257, AI828957, AW206245, and AW237541. HEPCE25 177 529343 1-202 15-216 AL034548. HBPCO59 178 761094 1-150 15-164 AI198719, AI381368, AI695853, AI620570, AA564802, and AA456099. HBPCT32 179 947081 1-843 15-857 AA913839, AA429491, AA428554, AA724454, AA868848, AA336014, AI190145, and AI125345. HEPCU32 180 931824 1-1512 15-1526 HEQAE65 181 911438 1-148 15-162 H83516. HEQAH70 182 699690 1-344 15-358 AL044222, AJ007558, AB018334, and AF165926. HEQAO76 183 769973 1-422 15-436 AL046469, AI962060, AF053944, AC006454, E07353, and AF053943. HEQAZ52 184 727051 1-745 15-759 T85314, AI360684, T91254, T85528, and T57321. HEQBA41 185 712243 1-685 15-699 AL039872. HETAD29 186 509311 1-254 15-268 AA336507, AA336418, AP001042, AP001043, and AF017257. HETAF20 187 509308 1-331 15-345 AA338023, AA336535, and AC002357. HETAF49 188 509306 1-500 15-514 R10452, R02534, AA336773, AA336549, R00052, AA704817, AA678320, and AI248957. HETAF89 189 509300 1-234 15-248 AA336405, AW248106, H24100, AW247283,AE161459, and AL110193. HETAH16 190 942612 1-335 15-349 AA337683, AA336632, AA157672, AA157671, W32894, AA359882, AA706316, AA385464, AA873028, AI961281, AW177658, and AD001502. HETAH66 191 799665 1-352 15-366 AA336517, AA336751, AA337580, AA336640, AA337190, AA336988, and AC005858. HETAH67 192 535390 1-304 15-318 AA336641, AA337920, and AA336746. HETAJ26 193 508994 1-241 15-255 AA337221, and AA336756. HETAK75 194 518156 1-315 15-329 AA336844, AA442492, AA394009, AI061614, AW327292, W76580, AA337096, N39773, AA287514, AA022944, AA355038, W16809, AA306378, W16892, W20041, AI038286, AA902825, AA431265, AI128035, AA437055, AA442618, H69650, AA333960, W16816, AA471293, AA429690, N39663, T81379, N42264, AW298810, AI582147, N95146, N28024, AA806403, AA181314, AA092603, N24270, N25823, AI206546, AI347368, AI093178, N26593, AI290898, AA676717, W16976, AA758626, AA846456, AA838697, N57221, N40080, AA927961, AA769954, AA729656, AA962149, AW118695, AA435600, AI187055, AI348195, AI223403, AA939313, AA282421, AA659796, AA640163, AI207323, AA436689, AA436861, AA437321, AA767427, AA807555, AW168756, N66030, H80473, N89586, H59458, AI292018, AW151976, D62144, AI887826, AI097028, N30575, AA831986, N89608, AA187056, N56324, AW137724, N27143, AA043993, AA740443, H98703, AA834618, AI269239, AA586548, AI393728, AA022924, AA989305, AA782538, AA287386, AA769511, AA255992, N26891, N67380, AI570699, H70497, H70481, and N89574. HETAN20 195 535359 1-345 15-359 AA336957, AA336982, and AA336981. HETAP59 196 509118 1-291 15-305 AA336978, AA337032, AA337033, AA279029, and AL133312. HETAP94 197 960392 1-307 15-321 AA336825, AA337256, AA337682, and AA337525. HETAR06 198 960839 1-301 15-315 AA337121. HETAR60 199 934444 1-296 15-310 AA337135, AI376239, AW405016, AW392584, AA782301, AL047643, AI061313, AA741301, AI557271, AA364567, AA412065, AL078581, AC004024, Z93023, AC004841, AC004991, AC004019, AP000555, AC005288, AC002094, Z83820, AC006538, AL049557, AC000085, AC004983, U91323, AP000228, AP000140, L29074, AC005844, AC004859, U95737, AC007429, AL022476, AC005058, AC003956, AL096776, AC004861, AP000088, Z83844, AC002350, AP000076, AC004854, D87001, D88268, AL022394, AC005746, AL022397, AC004467, AL022326, AC002477, and AC016831. HETAT83 200 918730 1-797 15-811 AA337275. HETAZ13 201 536192 1-313 15-327 AA337464, and AA298457. HETBA01 202 509189 1-225 15-239 AA337530. HETBF45 203 508655 1-318 15-332 AA337559. HETBH48 204 720853 1-298 15-312 AA337853. HETBR25 205 509099 1-482 15-496 R87344, AA338031, and AW155642. HETBW39 206 523046 1-334 15-348 HETCE12 207 971505 1-674 15-688 AA878439, AA337500, R11423, R05601, AA337219, AW373556, and AC005876. HETCE55 208 508666 1-444 15-458 H47564, AA336636, and AA336635. HETCG63 209 841924 1-1765 15-1779 AA336411, AA319330, AA337238, AA337599, AA337742, AI709289, W24609, AA308045, AI659881, AI803103, AW236950, AA336555, AW242783, AA630205, AA516061, AA337527, AA336474, AA782919, AL021878, AC005630, AL078475, AC006023, AL133371, AJ239329, AC007204, AC005574, AC005908, AC002485, AC004055, Z83820, AC004074, AL031432, AC006539, and AC004381. HBTCH92 210 921390 1-244 15-258 AA337969. HETCL55 211 522829 1-406 15-420 AW301200, and AI057175. HETDA81 212 525412 1-425 15-439 AI347829, AI539038, AA164850, AI862333, AI208103, T91042, W87820, AW103512, AA164851, AI538025, T83877, AI557283, AI673742, AA827331, AI565180, AI827139, AI590154, AA780419, AA551005, AI022058, AI886882, AI963604, AA164745, AC006047, AP000509, AC009542, AC009330, D84394, AL080317, Z97876, Z98750, AC004185, AC005023, and AF058907. HETDD18 213 509110 1-425 15-439 AA337063, and AB020858. HETDE67 214 883018 1-352 15-366 HETDE86 215 855509 1-384 15-398 AA337665, AI818119, AA337827, H55651, AC002051, AC002054, AC007664, AC008018, and AP000550. HETDG67 216 960870 1-645 15-659 AA337226, AA336474, AA460382, F35658, F28539, AA634465, AI963222, AI674747, AA337527, AA336555, AA336411, and AI709289. HETDI03 217 925489 1-145 15-159 AL049650. HETDL92 218 508990 1-260 15-274 AA337546. HETDN90 219 695021 1-257 15-271 HETDP21 220 525407 1-281 15-295 HETDT15 221 660714 1-788 15-802 N99226, N50058, AI709289, N66257, AI333306, AA999709, R16250, AI218967, AI201148, AI754092, AC004150, AC006539, AC007204, AC006024, U82672, AC005592, and AC004381. HETDW59 222 827093 1-278 15-292 AA337353. HETEB68 223 917400 1-257 15-271 HETEQ16 224 952297 1-259 15-273 HETEZ43 225 529591 1-347 15-361 AL034400, and AF030186. HETFA40 226 523112 1-464 15-478 AL021920. HETFC82 227 799658 1-530 15-544 AL121162, AI684248, AW371221, AW371225, AW371199, AW371191, AW371187, AL035291, AJ250075, Z96050, and AF097535. HETFE482289743511-696 15-710 AL035982, AI564005, AW074802, AC006062, AC007461, AL031223, AF074903, Z86064, AC005189, AL022159, AC006369, AC004787, AL049831, AL122007, AC006101, AF001552, AL109653, U73642, AC003002, AC006265, AC006972, AC002990, AC006305, AC006354, AC007486, AL008633, AC004382, AC005799, and AL031666. HETFG29 229 795274 1-958 15-972 AL045331. HETFI24 230 954104 1-1193 15-1207 AI687645, AL046701, AL041179, and AB011137. HETFI81 231 523398 1-349 15-363 HETFL39 232 973697 1-532 15-546 HETFM43 233 973702 1-399 15-413 N71545, AA019707, AW301855, AI560119, AA456149, AA503144, AI749306, AA056206, AA747375, AI125615, AL110391, T47613, AA826144, AA843450, AA828851, H94871, AW085794, AI890857, AA488111, AA284179, AA747480, AA077637, AA173334, AA747276, AL096775, AC005722, Z99716, U85195, AE000658, AC005037, AL135744, AC004973, AF001548, AL008716, U15422, AL022326, U91321, AC004595, AF196779, AC005921, AC005514, AL031687, AC006441, AL021391, AC007227, AL035588, AC008080, AL132992, AC000070, AC005778, AC005409, AC004878, AL050312, AC005600, Z81369, AL139054, AC002364, AC009247, AC006390, AC000082, AL021154, AP000512, AL035417, AL079295, AL031670, AL096712, AC005829, AC007021, AC004953, AC004890, AC002115, U89337, AC005320, AC005043, AL109984, AC006449, AC002090, AC006211, Z83844, AL135960, AJ131016, AC005996, Z82194, AC004797, AL009179, AL034400, AC007243, D26535, Z69709, Z81367, AC007207, Z99916, AC004517, AC005772, AL121578, AC006146, AC005940, AL078638, AP000692, Z97630, AL035086, AC002565, AC006511, AC002996, AC005191, AL034429, AC007436, AC004134, AC006530, AC002525, AL049830, AC005049, Z82198, AL021407, AL031774, AL049611, U95740, AL031005, AC005094, AL008719, AF053356, AC004913, AF052684, AC004955, AP001054, U78027, AL020995, AC005200, AL034420, AL050318, AL035460, AC006001, AL080243, AL031848, AC005104, AC006581, AC006536, AC002477, AC003047, AC009263, AC006116, AC007790, AL049557, AC007057, AC003982, D00591, AC006017, AF111167, AC004707, D89927, AP001052, AL133485, AL133448, AP000552, AL021878, AC007386, AL021937, AC005924, Z73359, AC004832, AL034424, AC005874, AF134471, Z86090, AL035072, AP000350, AF001549, AC005088, AC003663, AC000385, Z83826, AC006285, AC008040, AC011504, AC006312, AC007688, AC007055, AC004531, AC005082, AD001527, AC005261, AL132777, AC005480, AF015416, AC007917, AC007435, AL132826, AL009181, AC006071, AC005015, AC005747, AL031295, AC005366, AC004526, AL022318, AL033504, AC005488, AC005914, AC005399, AC018769, U07563, AC004783, AC004791, AP000140, AC004805, AC005533, AC005215, AL022721, AL031280, AL021939, Z94721, AL022718, AB000882, AC004477, AL031289, AL035422, AP000346, AP000563, AC004554, AC005071, AL023799, AP000359, AC007421, AL035420, AP000558, AL035415, AC003101, AL035249, AL132712, AF200465, AC005325, AL049631, AC005695, AC005562, and AC007387. HETGH30 234 527929 1-114 15-128 AC007655. HETGI40 235 505383 1-51 15-65 HETGL62 236 523372 1-316 15-330 AA857229, and AW207714. HETGL74 237 947978 1-598 15-612 R30743. HETGN20 238 927789 1-748 15-762 AA524918, AA524934, AW177242, AW177240, AW177241, AW177236, AW177243, AW177239, AI380737, and AW176018. HETGQ76 239 542486 1-177 15-191 HETG509 240 969632 1-160 15-174 HETHD30 241 935175 1-521 15-535 AA333629, AA380902, AA172147, Z55371, Z60082, Z57905, and AL023755. HETHE56 242 974348 1-245 15-259 HETHH49 243 967737 1-627 15-641 HETHO63 244 745503 1-585 15-599 H85494. HETHO78 245 963592 1-648 15-662 U59298. HETHR24 246 851412 1-448 15-462 AA296378, and AA298030. HETHT53 247 974555 1-427 15-441 Z69905, and AL049750. HETIF01 248 966185 1-209 15-223 AA585101, D57491, Z28355, AA585155, AA585476, AI546999, AA585098, D61254, AI541365, R29445, C16300, C16305, AI525556, AI541374, AA585439, T11028, Z30131, AI546875, AI525316, AI526184, AI546945, D55233, AI525431, AI547039, AI557262, AI541523, AI526140, AI557731, R28735, AI541205, AI541535, R29218, AI540967, D57186, AI536138, AI525306, AI526194, AI557734, D61185, D53447, AI535660, AI557727, AI557787, AI535639, R45895, AI557740, AI541307, AA585356, AI557807, AI546891, AI541013, Z32822, AA283326, AA170832, AI525320, AI526073, AA585329, AI557084, AI526176, C16293, R28892, T41289, AI557763, AA585453, R28895, AI557799, D53161, R28965, R29177, D60765, AI556967, C16292, C14723, R28967, AI526187, AI541514, AI546828, D59751, AI546996, C15069, AI541510, AI526113, D54897, I18597, AI541508, AA174170, AI546855, AI541534, D60844, AI541517, AI541346, AI547250, AI526180, AI557808, C15120, AI525339, AI525328, AI541527, AI557238, AI557796, AJ541415, AI541390, AI540974, C15406, AI525856, AL044162, AL041086, AL043496, AL041296, AL041233, AL043444, AL044529, AL044125, C14391, AA585325, AI541017, AL040193, AJ239433, AI541533, T41329, AI546829, AL041324, AL043538, AL040621, AL041347, AL041098, AL041163, AL041277, AL041358, AL041096, AL047012, AL040464, AL041346, AL040155, AL041197, AL043612, AI557602, AL039915, AL040463, AL047219, AL041227, AL047057, AL047170, AL040119, AL047036, AL041292, AL041051, AL047183, AL040322, AL041131, AL046330, AL041278, AL041133, AL041159, AL041238, AL041142, AL045817, AL040625, AL040510, AL043467, AL044186, AL044037, AL040091, AL040128, AL040168, AL040255, AL040285, AL040342, AI557533, AL040332, AL040617, AL045684, AI540882, AL040745, AL040370, AL043677, AL040529, AL046442, AL040839, AL041752, AL041168, AL043775, AL044165, AL043492, AL041602, AL045920, AL037436, AL038838, AL044074, AL041635, AL045990, AL040458, AL044199, AL044187, AI557279, AL040090, AL040263, AL040294, AL040329, AL040082, AL044272, AL040444, AL041186, AL040148, AL041730, AL041523, AL043627, AL079878, AL046392, AL041374, AL040052, AL043845, AL039338, AL042135, AL044064, AL038983, AL039316, AL043923, AL043814, AL043848, AL037435, AL041459, AL043570, AL041577, AL044201, AL044258, AL046850, AL038532, AL040768, AL037727, AL046994, AL040414, AL040571, AL046914, AI142134, AL043537, AI546831, AL041140, T23985, D59436, AI557408, AL045725, AL040238, AA585378, AL039744, AA585434, AL040253, AI557864, AI541356, AR062871, A25909, AR038855, Y09813, A85395, A85476, AR037157, AJ244005, Y16359, D50010, AF082186, AJ244004, AR062872, AR062873, D78345, U94592, A20702, AR017907, A20700, AJ244003, A43189, A43188, AR038762, AJ244007, Z32836, A70872, A70869, A98420, A98423, A98432, A98436, A98417, A98427, A98767, A93963, A93964, I63120, I44681, X83865, A84772, D13509, A84776, A84773, A84775, X81969, A84774, AR054109, AR067731, AR067732, A86792, A58522, A91750, AR008429, I13349, A60212, A60209, A60210, A60211, I18895, I05558, AI8053, AB025273, I08396, I08389, I84553, I84554, I15717, I15718, E03627, I48927, A90655, D13316, A02712, A77094, A77095, A81878, A95051, I06859, AI8050, A23334, A75888, I70384, A64973, A60111, A23633, AR007512, AR031566, A35536, A35537, A02135, A02136, A04663, A04664, AR038066, I00682, AI1623, AI1624, E00609, E13740, AI1178, E01007, AI0361, AR043601, M28262, AI1245, I03331, A02710, E12615, AR035193, A92133, E14304, A07700, AI3392, AI3393, I62368, AR031488, I13521, I52048, A27396, AR027100, I49890, I44531, I28266, I21869, A91965, I44516, A70040, E16678, A82653, E16636, A93016, AF149828, A24783, A24782, A95117, A58524, A58523, I08395, AC005913, I19525, I01995, I25027, I26929, I44515, I26928, I26930, I26927, I08051, I60241, I60242, AR051957, A20699, E00696, E00697, E03813, I66482, AR009151, I66485, I66483, I66484, I66498, I66497, I66496, AR027099, I66486, I66487, A22738, AR051652, AR051651, X07299, AR064707, AJ230935, E17098, I66495, I66494, AJ230972, A22734, AJ231028, AR022273, AJ230902, AR054723, X55486, AJ231009, AJ230845, AJ230867, AJ230951, AR051864, I36244, A06631, S60422, X82786, AR051865, B12584, AR063812, Y14219, AR035975, AJ231011, AR035977, AF006072, X76012, I05845, AR031358, AR031365, AJ244006, AJ230996, AJ243486, I03669, I03668, A16035, AR003381, I33632, AR017826, I18302, AR035974, AR035976, AR035978, E03654, A24548, A24546, AF213384, AF147331, M11147, X03743, A62298, AR050070, A82595, A82593, X82834, M10119, A22739, A05993, and A05991. HETIG71 249 974359 1-397 15-411 HETIJ84 250 766589 1-386 15-400 AA359333, H80204, T81361, W39405, W26521, AL037788, AI340563, AA831054, AI942228, AW025654, AI656682, AI867892, AI392798, H78428, AI431922, AI935355, N74643, AA470851, AI984946, AA136269, H58033, R24652, W25612, N88059, and AF161432. HETIJ85 251 883991 1-270 15-284 AA336474, AA336555, AA634465, AI963222, AI674747, and AA337527. HETJQ89 252 764951 1-367 15-381 AA732024. HETJU60 253 739804 1-632 15-646 HETIY84 254 935947 1-152 15-166 AW410053. HETJD30 255 974558 1-651 15-665 HBTJD86 256 909130 1-637 15-651 AA283174, AA813107, N85059, AI829548, H66598, H47422, AI025850, AW193437, AL049869, AB023214, AC004230, AL133163, AL024498, AC006006, AC005393, AL031722, AC009516, AP000557, AC004463, AC002316, AL030995, AC004799, AC004876, AC005696, Z93023, and AC005015. HETJG63 257 950017 1-480 15-494 HETJI32 258 806435 1-600 15-614 R02503, AA873257, AI791771, AL021997, and AC005678. HETJK67 259 751072 1-491 15-505 HETTN51 260 767932 1-544 15-558 HETJT95 261 789310 1-401 15-415 AA528140, AI375677, AW237773, AI624970, AI420574, AI244780, and AI624952. HETJX04 262 927120 1-848 15-862 AA853282, AA370481, AA625156, AB025258, and AB025259. HETJY11 263 966194 1-603 15-617 AA356376, AI354409, AA610255, AA577824, AA158549, AL120004, AW265688, AI583532, AW265276, AI049630, AA701122, AI801505, AI283938, AI243793, AW403829, AA491423, AI417469, W96277, AI565084, AI358776, AA626840, AA558404, AA502110, AW089625, AI133514, AI733856, T47138, AW268329, AW275432, AA551067, AI049845, AI421257, AA834816, AI061303, AI687972, AA297789, F31811, R70883, AL041375, AI912401, AA133293, AI090334, AI538404, AI336771, AA632556, AW069227, AA176605, AA612727, AA102737, AI252726, H95865, AI623364, AA484022, AI255083, AI634187, AW008184, H29914, AA599532, AI369076, AA525331, AA582746, AL040430, H67064, AI671077, AW068580, AA020873, AW243945, AA515924, AI355246, AA557945, AA513851, AI473995, AA493789, AA581471, AA485343, AA609826, AA846923, AA018923, AW167202, AW341955, AA608675, AA630854, AI567391, H43771, AI054030, AA376358, AW238341, AW237905, AI932871, AI457313, AA218684, D44672, AW129188, AA084320, AI474127, AA444166, AI431513, T15767, AW341978, AI469564, AA610433, AI520925, H01243, AA831426, AI309943, AA491767, AA302982, AI049701, AW270385, AA182731, AA551035, F35674, AA910941, AI720403, AI570237, AI610468, H61742, N33587, AI358928, AA489856, AI073373, F00533, AA857812, AI125143, AW236219, AA501782, AI282724, AA666295, AI869797, AI246386, AI816058, AC005015, AC002350, AC005839, AC002470, AC006512, AF001550, AL133246, AL009031, AC002326, AC007225, AF064861, AC003041, AL049766, AC002126, AC005874, AF134471, AC006277, AL109628, AC006312, Z99943, AC005089, AC005736, AC006160, AC003037, AC009044, AP000501, AF205588, AC008372, AC005067, AC004526, Z84487, AC006050, AC005920, AC007057, AP000252, AL132712, AP000212, AP000134, AP000704, AF047825, AL031584, AC006449, AC005779, Z83846, AL022163, AC006059, AC002351, AC003104, AL050318, AC004531, AL117352, L14561, AC005531, Z95331, Z98050, AC005529, AC002128, AL135744, AC004230, AC007488, AC005722, AL034549, AC007546, AC006501, AC004983, AC007878, AL049829, AC000004, AC006459, AC004755, AC006285, AC009509, AC005527, AC006130, AL035587, AC006480, AL031729, U91323, AC004686, AC005765, AC004106, AC006084, AC007226, AC004820, AC004491, AC004019, AL031003, AC004865, AL034420, AC002045, L44140, AL031228, AL109758, AC006380, AF111170, AL031311, AP001053, AC006529, AC007193, AC006581, AC003689, U95090, AC004895, AC005081, AL031258, AC008040, AC003071, AP000321, AL035684, AC006023, AC004985, AL078463, AL034417, AC006211, AC006071, AL021920, AC007308, AC006252, AC004813, AL096712, AL096701, Z99128, Z83844, AC006946, AC005593, AC006165, AC005300, AL031005, AC005197, AC016025, AL132987, AC007114, AC007899, AB023051, AC007050, AC000082, AC003982, AC005914, AC007695, AL031685, AP000121, AP000167, AP000052, AC004125, AC020663, AL121825, AC006571, AP000952, AL133245, AF067844, AC003963, AP000512, AL031597, AC005829, AL049760, AC005696, AF196779, AC005006, AF207550, AF157816, AC016027, AC004448, AC004408, AC006064, AC005803, AC005523, AC007637, AC016830, AC002404, AC006121, AC004000, AL035079, AC006966, AC005057, AL034582, AC007277, AC005755, AC008149, AL031681, AL009181, AL049776, AL023879, AC004596, AC002312, AC005071, Z98946, Z95115, AF134726, AL096791, AC002425, AC005086, AC004955, AF001549, AL121603, AL117337, AL021453, Z68870, AL080243, AC004973, AL117258, Z97989, L78810, AC005900, AC004695, AL117694, AC007151, AP000689, AL023807, Z98941, AL109798, AL022476, AP000152, Z82206, AB020868, AL049839, AC007279, AC005037, AC007686, AC004771, AJ003147, AC004878, AC004933, AL020997, Z95116, AL035423, AC006132, Y18000, AC004655, AP000356, AC002476, AF165926, AC005972, AC003108, AF053356, AJ246003, AC004967, AL049712, AC007684, AP000115, AC007649, AC003962, AC003950, AP000694, AL031588, AC005377, AL049636, AC005004, AC002991, and AA910844. HETKA38 264 894600 1-649 15-663 AI799104, AA972394, and R07977. HETKG67 265 974355 1-718 15-732 AW084172. HETKH01 266 915320 1-302 15-316 HETKH92 267 790910 1-198 15-212 AR062277. HETKM55 268 974362 1-730 15-744 HETKQ65 269 855449 1-474 15-488 AA336548, AJ251025, AC002098, and AJ251029. HETKV26 270 910030 1-680 15-694 AC003665. HETKX91 271 789797 1-307 15-321 HETKZ65 272 941045 1-608 15-622 AA312013, and AF067972. HETLB04 273 920894 1-1373 15-1387 AA702803, AI803643, AI566865, AA766437, AW005007, AA043795, AA683129, AI817677, AA512883, AA505838, AA631295, AA808400, AA599331, AI826399, AA767812, AA808767, AW385923, AI016110, AA570116, AA437055, AA471293, AA394009, AA442492, W16809, AA306378, AA287514, AW327292, W20041, T81379, W16892, W16816, W76580, AI086244, AA022944, N39663, N39773, N28024, AA355038, N40080, T24737, AA333960, AA337096, AA336844, AI061614, AA092603, H69650, N95146, W16976, AA431265, and AW298810. HETLH89 274 786458 1-249 15-263 AA463820. HETLM46 275 974361 1-429 15-443 AC006478. HJMAE34 276 957079 1-292 15-306 HJMAZ84 277 919847 1-398 15-412 AA002128, D80614, AI936856, AA454962, W45609, W25476, H79084, AA253291, D81240, D81550, AI310465, AA454963, AW187987, H77419, AA443024, D61329, AA878315, H93507, D61227, H77765, AI991959, AI571297, N66618, N93599, AA926681, AA861197, AW341582, AI130710, AI089399, AA565959, AA428582, AA855002, AI052480, AA463465, AA502363, AA926699, H93719, AA226686, H79085, AI167771, AI084567, AA594578, AA548424, AW263196, AI123575, AI806033, AI185582, H26225, AA977298, AA904619, AA913056, AA830635, AA809388, AI418325, AA954613, AA428581, and AF151109. HJMBT23 278 858254 1-657 15-671 W68790, AI553754, AA741320, AI791865, H20412, AA865287, AI340302, AI681259, AW450355, AI215794, AI767774, AI991972, AI807751, AA378382, AI369759, R43803, AW451952, AA642194, W68697, and AA243542. HLMNG77 279 675752 1-238 15-252 AW170054, AI198826, AW104425, AI269001, AI188129, AI217517, AI695935, AA758120, AI016865, AW104993, AB011129, and AC020663. HLWAB50 280 856552 1-353 15-367 HLWAD08 281 958554 1-282 15-296 T23963. HLWAG51 282 964389 1-1712 15-1726 AI742201, AA702146, N41421, N42024, R53820, AI040758, AI022068, N29636, R74596, AA678080, AI743349, N92675, R56690, AA034028, AI471941, AI241444, AA331067, R81024, H54160, H59318, AI184751, AA779352, N41642, R22378, H66306, H13492, N30300, N26409, R27135, H00724, R74487, T86855, R56846, N73527, AA461540, R32619, R53865, R78495, AA367506, W90130, R27290, R21881, C17564, N63764, W90088, AI220639, H67730, H54003, R25201, C18787, R32507, R23955, H00639, R80819, AI248028, AA367507, H59271, AA368366, R23956, H13441, AA938123, and AW390834. HLWAH41 283 944774 1-946 15-960 R98276, I95945, W33061, AW392670, AW384394, AW363220, U46351, AL119457, AL119324, AW372827, Z99396, AL119497, AL119319, AL119341, AL119443, U46341, AL119355, AL119484, AL119363, AL119391, U46350, U46347, U46349, AL119444, AL119483, AL119396, U46346, AL119335, AL119418, AL134902, AL119522, AL119439, AL119401, AL134528, AL042450, AL119399, AL037205, AL119496, AL134533, U46345, AL134536, AL042614, AL134525, AL134538, AL043019, AL042965, AL042975, AL042544, AL042896, AL043033, AL042984, AL042970, AL042542, AL043029, AL042551, AL043003, AL119464, AL119488, AC000047, AB026436, AR054110, A81671, AR066494, AR060234, and AR069079. HLWAJ13 284 920690 1-869 15-883 AI032745, AA024482, AA922863, AI701944, AI150858, AI270332, AI151319, AA858133, AW135972, AI093066, W38159, AI247539, H04083, AA641624, H02150, H01456, AA382448, H04750, T49622, AI219287, W02674, AA676625, AI961431, H02149, N27194, AA595296, AA004543, H01225, I58656, AA649738, H01013, AA641643, AA897262, H03388, R63061, AW386273, AA909471, AW389613, R71626, R71240, AI634930, R25176, R79411, AW389614, R79410, R76109, AI202312, AI866010, R24676, W57657, W25628, N39940, AA393303, AC004231, and AL117538. HLWAJ64 285 746460 1-36715-381 AA654781, AA526630, AA478355, AL037771, AI630176, AW275498, AI470646, AI124610, AA846952, AW410354, AI042311, AA837087, AI174766, H23653, C18993, AW089101, AL036037, AL119691, AA493695, AW238121, AI049508, H18354, AL135357, AA523841, AI343233, AI560085, AW080811, AA302973, AA292178, AL039145, AA630672, AA063173, AA704393, AW168520, AI933579, AL037383, AI783581, AA809546, F00107, AA468131, AI366993, AW021735, AA507824, AW303008, AA904274, AA679936, AW168420, AA613789, AA279421, AA640410, AA640430, AI345157, AA303007, AI963720, AW150476, N72663, AW166808, AI246796, AW268973, AI612142, N41888, AA483256, AL043719, AI864813, AI732120, AA174016, AW440545, AA174017, AI818737, AI687343, AA548058, AL121871, AF196779, AL034379, AC006552, AF114156, AC004999, AC006241, AC005412, L44140, AC006001, AC004000, AL033392, AL031283, AJ229042, AL022320, AC006316, AC004707, AC003046, J02846, AC004156, M16553, U80017, AP000114, AF130343, AC005877, AP000466, AP000952, AC004887, AL031311, AC002418, AL096702, AC006509, AC006111, AC006511, AP000503, AP000151, AC005031, AP000013, AP000010, Z69719, AL031432, Z82173, AC005701, AL078477, AL035458, AL031123, AC005089, AC004963, AC007666, AL049569, AF134726, AC004985, AC004386, AC006115, AL034417, AC002117, AC007151, AC004087, AL022313, D87675, AC004019, AC000052, AF031076, AL023807, AC002310, AC004098, AC003043, AJ239322, AC006203, AC004983, AC006014, AL008729, AC004922, AF050154, AC003684, AL135744, AC004417, AC005703, AL031594, U95739, AC006468, AC005519, Z83846, AL049643, Y07848, AL133399, Z82214, AC007630, AC002522, AC006960, AP000155, AC007917, AC005300, AC005207, AL021546, AC007066, AC005156, Z54334, AL034420, AL050318, AC005231, AL035413, Z84469, AC005242, AC004819, AC005803, AL096843, AL050325, AC007551, AL049776, AC005488, AL109758, AC007971, AC005815, Z94044, AC004832, Z68321, AC007237, Z94056, AC005067, AC005602, M89651, Z97630, AB023049, AC004253, AF030876, AC005940, AL035072, AC002390, AC007686, AF064861, AC003083, AF030453, U40369, AC002377, Z99716, AL049867, AL022721, AC007676, Z98752, AC002540, AF176815, AC006965, AL031427, AC008394, AC000120, I05724, AC006211, AL109984, AC006985, AC003109, AC005261, AC005307, AC002352, AC005088, AC006571, AL031257, AC005808, AC009516, AC006064, AP000557, D00596, AC006265, AC006515, U47924, AF047825, AL121655, AC005498, AC004217, AL022239, D83989, AC005914, AL035461, AC006261, AC004144, AC005180, AC009247, Z98051, AC005484, AL022326, AC008044, AC005725, AF207550, Z98884, AP000350, X54181, AC004142, AL008718, AL033543, AL031259, AC004241, Z49918, AF024533, AL035450, AC010168, AC004968, AC006368, AC007055, Z82178, AC007298, AL122020, AB000877, Z94721, AP000553, AL022238, U96629, AC002400, AC003982, AC005785, AC002528, AL049766, AC003972, AC009509, AC008119, AC005520, AC007312, AC006125, AC007292, AC007848, AC007136, AC007226, and AL035462. HLWAK69 286 694216 1-551 15-565 H69568, and AL022393. HLWAK94 287 715727 1-394 15-408 R80441, R53837, AA367782, AA713884, AA713743, and AB033064. HLWAR77 288 947484 1-1275 15-1289 AA449919, AA449920, and AF119815. HLWAR78 289 723330 1-495 15-509 AA367499, and AI138461. HLWAU18 290 666273 1-439 15-453 H68343, AI915081, H40478, AA586433, AA326452, AA808631, AA650447, AW265688, AA837771, F17700, N89894, AI567391, AA523293, H63660, AW264393, W18189, AA533408, AA715955, AA582746, AA507993, AA339923, AA904211, AA452569, AL134167, AA937809, F31867, F33037, AI791185, AA745524, AA947369, AI243793, AA878407, AA021139, R93854, AI185394, F30310, AI801563, AI565084, AI923052, AI580707, W78056, AA297006, AA228778, AA526424, AA936718, AI198718, AA347927, AW151541, AA297496, AW366361, AI270647, AA668587, AI370475, AW082076, R70883, AI858889, AI821273, F09355, R70884, AA947375, AI697242, AA658934, AA365744, AI521525, AW002831, AA558366, AC003982, AC016025, AC005180, AC006285, AL009181, AC002310, AC005519, AC005516, AC005746, AC004797, Z82194, AL050348, AL050307, AC002128, AC004623, U52111, AF067844, AL080242, AP000553, AC009516, AF161800, AC005037, Z82215, AC002511, AL133353, AL021977, AL008723, AL031577, Z82172, AC006160, AL024498, AL049538, AC020663, AL096757, AL135922, AL023553, AC006356, AP000496, Z98200, AC000134, AC007536, AC006205, AC007324, AC004453, Z96811, AC003002, AF104670, AC003664, AC006466, AC005231, AC004594, AL035400, AC005182, Z82245, AP000533, AC005841, AC007688, AL031595, AL031643, AC005899, AL078463, AC005520, AL035443, AC005383, AF111170, AL033375, AL110503, AL132800, X87344, AF001549, AC005914, AL050318, AC006449, AL022316, AB012113, AP001056, AF108083, AC007393, AL035659, AC003976, AL032821, AC005486, AC009181, AL021368, AC008040, Z97183, AC006965, AC004887, Z95115, AL109758, AC005944, AR020909, L76927, AC002120, AC002347, AC007681, AC005881, AL031657, Z69921, I34294, AC004983, AC004961, AL034553, AC005064, AC004020, AP000552, AC005291, AC002991, AC002492, AL022326, AP001138, AC005484, U91325, AC005702, AL021395, AC007225, AC000353, U95742, AL133448, AL008720, AL022322, AC006486, AC005277, AC005244, AC004832, AL033397, AC016027, AC016830, AL135960, AJ131016, AC002044, AL132712, AC005071, AC007216, AC006035, AL049696, AC005962, AC006166, AL049760, AP001054, AC002477, AC004631, Z97184, AF031078, AF030876, AL031311, AL133371, AC005049, AC006529, AC007292, AC008989, AC006473, AP000695, AC005193, AL122021, AC005378, AL049697, AP000696, AC008012, AL022721, AC002394, L25272, U02052, D79983, AL049713, AC004653, AL035682, AC005255, AC002364, AC006344, AL021528, AL034400, AL031667, AL021578, AC007263, AC007919, AC005940, AC005527, AC005768, Z84496, AL024493, AL050332, AC003 688, AL049634, AL096712, AC007395, AC005179, AB023051, AL035071, Z93930, AL008632, AC004073, AC004622, AL035460, U91318, AP000501, AC005683, AC004056, AC006064, AC005736, AC002543, AL096701, AC004528, AL035462, AC006388, AC008150, AL096704, AP000152, AP000011, AL035423, AC005878, AL117344, AC005220, AC007663, AF111168, AP000300, AL049869, AF038458, AC007695, Z98048, AF217403, AL031845, AC004030, AL031300, Z75407, AD000684, AL110114, AC004854, AP000495, AC005476, AL031276, Z98742, and AL021939. HLWBA11 291 966796 1-338 15-352 HLWBA25 292 677944 1-440 15-454 N47928, D78769, AA002046, AI655391, and C16888. HLWBE31 293 934562 1-329 15-343 HLWBE92 294 791362 1-505 15-519 AA368122. HLWBJ02 295 919639 1-371 15-385 AL133404. HLWBK40 296 711000 1-432 15-446 HLWBN49 297 713600 1-1086 15-1100 R27276, R83085, N79154, R67710, H67488, R66311, H54211, H80349, R27267, H66895, H87378, N99360, W03263, N62439, N69438, N71427, and AC005281. HLWBO68 298 529323 1-221 15-235 N52311. HLWBQ84 299 782938 1-251 15-265 HLWBQ86 300 703465 1-475 15-489 AA947352, AA493245, AI307563, R00693, AI358505, AA629668, AA772493, AA557945, AA640305, AA152398, I47075, AA633804, AI344906, AI754257, AI523356, AA584360, H81012, AI620666, AI459879, AI318548, AI885896, AI567676, R79396, T52366, AI114755, AA155817, AA156183, AA349923, AA636077, F35374, AI631299, AA643768, AA524604, AI300507, AW157128, AI969090, W03800, AI803824, AW080118, AW407679, AA601290, AA573564, AW277240, AA369465, AI309059, AI251024, AI828721, AA569220, AA995445, R26871, AW021674, AA015948, AI572680, AW149241, R87909, AI147511, R88475, AI925588, M77964, AI860648, AA447247, AI174701, AW273201, AW273146, AA804975, AW192002, AA522864, AA809104, AI821945, F00937, H53109, AA639209, AA486896, AA526542, R91138, T57516, AA021061, AI002950, AA503932, AW008217, AA604601, AA579082, R86876, AW366198, AA669458, AA351868, AA629533, T57562, W69639, AL022097, AL031594, AC006315, AC016027, AP000692, AC005932, AC003102, AC007298, AC016830, Z97630, AC005255, Z69650, AL022323, U80017, AC005844, AF207550, AL031311, AC004447, AC007227, AC007707, AC005031, AL008734, AC004999, AC007690, AL121603, AL132994, AC006120, AC005516, Z97632, AL133355, AC006162, AL035458, AL031427, AC007381, AC000003, AL031229, Z74696, AC005664, AC005206, AP000275, AC005355, AC005251, AC005667, AC002491, AC004913, AP000037, AP000105, AP000469, AL031657, Z98950, AC005993, AC002395, AP000356, AL049759, AC007263, AC006948, AC006538, AC004856, AL121652, AC004477, AC004835, AJ003147, AC002465, AP000694, AC004997, AC005703, AB001523, AC005581, AL121580, AP000509, AC005585, AC000084, AF111169, AC005821, AC005663, AL049562, AL022165, AL096712, AL021877, AC005231, AB023051, AL049761, AC004991, AL034420, AL031177, AC005589, AC004257, AC005180, AC004953, AL031291, AC006512, AL021393, AL080243, AL122020, AC004805, AL022726, AC007022, AB020873, AL139054, U51280, AC007243, AC005331, AC005305, AC006048, AC007283, AC006057, AP000099, AL008716, AC004150, AL031680, AC005913, AC004876, AC001551, AC004806, AC007361, Z83826, AL035079, AC004914, AC007877, AC004458, AC005632, AC006312, AC005914, AL049776, Z84718, AC007637, AC005209, AP000512, AJ251973, AC002369, AC004254, AC005519, AC008115, AP000036, AC000070, AC003999, AC005602, AL035460, AF006501, AL031674, AP000351, AL031186, AC002477, AL096701, AL049709, AL031284, AC006236, AC007390, AL020997, AL110502, AL024498, Z84469, AC004859, AL035455, AC007564, AC006079, AC004832, AC005822, AL121595, AL022067, AC007314, AL096791, AC005746, AC005041, AF107885, AC004801, AL135744, AL049780, AC007055, AC002524, AC005049, AF109907, AL031721, L47334, AC010205, AF015262, AC004076, AC004560, AL133448, AL022315, AF205588, D34619, AC004921, AJ229043, AL021395, Z98742, AC016025, AL132826, AC003957, AC008171, AL031670, AC002079, U73479, AC000075, AP000260, U95739, AL035209, Z82201, AC006547, Z81450, AC002302, AC004652, AP000503, AC004659, AC006013, AC007050, Z82198, AC005060, AC004500, AC005755, AL096757, AJ133269, AC006511, AC009405, AF111168, AC005318, AC004032, AL021391, AL049777, AC005837, AL031985, AC005759, AC004854, U89337, AP000030, AL021155, AL031587, Z83846, AC006390, AL031058, AC002364, AL031767, AL022326, Z97056, AC006597, AC005856, AL022313, AC004000, AL022302, AL132992, AC004099, AC004796, AL022336, AC004695, and U91326. HLWB514 301 925300 1-271 15-285 HLWB543 302 774175 1-448 15-462 HLWBZ74 303 679215 1-532 15-546 H12696, AA367915, and AC005281. HLWCA67 304 577929 1-886 15-900 W81241, H12868, H60705, AW393433, R73306, R65857, AI091425, AI808222, AI149187, AA994537, AA700322, AC000115, Z97632, and AF137387. HLWCM44 305 727699 1-310 15-324 AL121578. HLWCM70 306 926850 1-343 15-357 W31589, AI829352, AI982989, R45778, AI346428, AA031570, AA602550, AA455757, AI342486, AA031571, AI394271, AI754665, N51169, AI908523, N50210, and AC005832 HLWCO66 307 750779 1-519 15-533 HLWCQ53 308 869700 1-632 15-646 R24069, AI148527, AA513449, AI809692, AW452872, AA954445, AA812573, H57889, AW183378, AI619978, AA813225, AW197888, and R26598. HLWCQ62 309 742778 1-824 15-838 AI024849, AI024871, N47115, and N50324. HLWCQ76 310 768018 1-261 15-275 AI828591, AI954470, AI799304, AI814054, AA455520, T91958, AL135108, and D80002. HLWDA01 311 913768 1-530 15-544 AB020629. HLWDB18 312 790969 1-688 15-702 Z43873, AA502583, W23097, AL048979, AI797390, AI656908, AI194040, and X99253. HLWDD02 313 953283 1-412 15-426 HLWDE60 314 868276 1-439 15-453 AC007073, U95626, and AC004065. HLWDL71 315 759843 1-38 15-52 HLWEE76 316 973315 1-384 15-398 HLWFG82 317 929647 1-545 15-559 AI802325, AI161267, AI885931, AA219338, AI660388, AW170791, AW410057, and S56581. HLWFQ04 318 856488 1-703 15-717 AB023186. HMVDU41 319 957804 1-600 15-614 AW195334. HNBTP01 320 914428 1-943 15-957 AI218626, AI076006, AI922744, AI797880, AI872391, AI559566, AW162613, AI565503, AA449042, AI857802, AW248493, AA074070, AA679085, AI922373, W76538, AA581796, AI292006, AW172513, AI609183, AI682939, AA747871, AA449757, AI885613, AW268637, AA928020, AA568598, AI683858, AW073851, N79729, N62781, AI371131, AI367698, AI884907, AW191998, AW016535, N93245, AA379280, AA568887, AA649970, AW264577, H20460, AI221886, AW000860, AI275195, R42681, AW162711, AA460372, AI699657, AW304978, AI081779, AI560482, AI279653, AW243790, AI951374, AW183962, AI696251, AI904299, T78554, R43259, AW079129, AA147203, AI499410, AI475009, AA732831, AA375228, AA379846, AA783050, R51077, N47545, AI474934, Z41466, AA160401, AI678630, Z41592, AW079321, N47546, AI252528, R58857, AA971563, AL022238, and AL137499. HNBTT79 321 965424 1-228 15-242 HNBTX52 322 965428 1-327 15-341 F35097, F24745, AW071109, AA528500, AA460268, H48768, AA715075, AA593273, AA715173, AI820526, H73306, AA648957, AA836548, AW439703, AA846482, T47889, AA708194, AA772704, AA302690, AA890060, T54173, N36143, AA058312, H58883, AL117352, AC007011, Z97056, AC002425, AC003982, AL022336, AC002492, AC002070, AC004125,AC005753, AC004963, AL035461, AC005520, Z95152, AL031984, Z95115, Z85996, AL035681, AL035455, AL031284, AC005243, AC007707, AC005233, AC002310, AL035088, AF165926, AL117337, AL034549, AL132712, AC005666, AC002563, AL033538, AC002420, AF205588, Z96753, AL135783, AL031657, AL109628, AC002045, AL049576, AC000015, AL031283, AC004962, AC000026, Z93241, AC006449, AC002059, AC005225, AF129756, AC007057, Z82182, AL034429, L78810, U67809, AC004167, AC009044, AC006064, AC005962, AC006360, AL023807, Z86090, AC007201, AC007880, AC003666, AC007283, AC003070, AC002369, AC004851, AC005519, AC004638, AC006262, AC005081, AC007919, M89651, AC005971, AC004601, AC005940, AL021977, AC005730, AC002452, AC004923, AL050318, AC009509, AC005231, AL080243, AC002390, AC009288, AL031643, AC004832, AC004821, AC005722, AC003681, AL049776, AC002429, AP000552, AL031651, AC006958, Z83846, AC005684, AC005335, AC004882, AC005924, AP000135, Z82205, AC004554, AF196969, AC012085, AC004703, AC011718, AC005102, AC005191, AD001527, and AC007052. HNBUM19 323 933672 1-469 15-483 AI460390, AI141130, AA364420, AA557913, AI185394, AI267884, AI251429, AA639114, AA687542, AL042771, AW264901, AA603264, AI821805, AI821056, AI792092, AA278496, AI446205, AW270768, H72278, AW008074, AI291037, AW277174, N27751, AI436378, H63154, AC005180, AC004895, AL049795, AC002091, AC005562, AC009516, AC005015, AC008044, AF030453, AC007565, AC003663, AL096791, AL049780, AC004985, AC005914, AC003101, AL049776, AL080243, AC006312, AC005081, AF053356, AC007676, AC005229, AC005755, AP000558, AC006571, AL022313, AL031427, AC007686, AC005088, AL133163, AC002477, AB023049, AC005003, AP000552, Z83826, AL079304, AC004386, AC006088, AC006530, Z97054, Z93023, AC004890, AC000353, AC007226, AC005971, AP000704, AL049757, AC002301, U91323, AC008372, AC003982, Z83840, AF207550, AL109628, AC005829, AC002350, AL008582, AL135744, AL139054, AC006039, AC004491, AF050154, AC004033, AJ003147, AC005500, AP000557, AL049653, AC002310, AL031680, AC004967, AP000556, AC004019, AC006509, AL049766, AL031311, AC005086, AC006285, AC004662, AC007540, AP000501, AC005037, AC004878, AL024498, AL035079, Z85986, AC005225, AL031587, Z98200, AC004821, Z97056, Y14768, AC006511, AC004841, AF024534, AC008040, AC007283, AC006101, AF047825, AC005921, AL096701, AC007546, Z95331, AC007229, AC004144, AL023553, AC002418, AC005412, AP000505, AC005519, AC007216, AC005071, AC005261, AL034451, AC005332, AC007151, AC002365, AL035072, AL031255, AC005839, AC006468, AP000512, AC006064, AC005484, AL008718, AF111167, AC006111, AC004876,U80017, AL034429, AC005666, AC004526, AF111168, AC006277, AL031659, AP000008, AC002492, AP000692, AC007055, AP000555, AF165926, AC005488, AC006211, AC005746, AL022163, AF196969, AC005295, AF067844, AL022302, AC002115, U29895, AC002996, AF129756, AC005031, AF134726, AP001052, AL023575, AC005940, AL022721, AL022318, AL031005, AC004477, AC005695, AC004854, AC005944, AL049692, AP000553, AC002375, Z82203, Z98742, AC004832, AC005841, AF196779, AL031589, AC007993, AC005300, AC005696, AL078581, AC005049, U82828, Z82976, AC006160, AC005529, AC006251, and AC002126. HNBUR07 324 951814 1-442 15-456 AA759267. HNGAO08 325 958685 1-286 15-300 AC003101, AC006974, and AC004099. HNNNA06 326 917723 1-1581 15-1595 AA779932, AW069784, AW194351, AI202042, AI128373, AI128364, AI143847, AI990994, AI421235, W95217, W78812, AA855140, AA527080, AI151527, W68234, AA441818, AA143612, AI275577, AI278683, AA908252, W68235, AW195552, AA676541, AI219401, AW291524, AI299109, AI192236, AA862317, H01997, H56734, H83578, AA884790, H82711, AA774498, AA633305, H94868, H79699, H84425, R09902, I90526, AA904994, AA441880, H03628, AI219227, H03629, AI080080, R73007, H56655, AI567570, R81684, W94691, R81474, R81669, T83566, R12503, H52108, T83061, AI444952, AA342086, H02094, H84426, N58039, AI658795, W80711, and H79700. HNNNA09 327 917724 1-548 15-562 AW069784, AI128373, AI128364, AI202042, AI143847, AI421235, AA779932, AI990994, AA143612, AI151527, AW194351, AA441818, AI275577, AA527080, AI278683, AA908252, W68235, AA855140, AI219401, AA676541, AW195552, AI299109, AI192236, AA862317, H01997, H56734, H82711, AA884790, H94868, AA774498, AA633305, H03629, T90526, AA904994, AI219227, AI567570, AI080080, R12503, R81669, W94691, H52108, AI444952, AA342086, H84426, W78812, N58039, W80711, H84425, R73007, H79700, H03628, and AI658795. HNNNA77 328 917725 1-1103 15-1117 AW291524, H83578, AI202042, AA779932, AW069784, AA143612, AI128373, AI128364, AI143847, AA441818, AI219401, AI278683, AA862317, AA884790, AA633305, AA774498, AA527080, AI421235, AI275577, W68235, AA908252, AA676541, AI151527, AI299109, AI990994, AW194351, H56734, AI192236, H94868, AW195552, H01997, H82711, AA904994, AA855140, AI219227, H03629, AI080080, R81684, I90526, AI567570, W94691, R81669, W68234, R12503, H52108, T83061, AI444952, AA342086, H56655, W80711, R09902, T83566, H84426, N58039, H79699, W95217, H79700, and W78812. HNOA506 329 933730 1-738 15-752 AW183087, AA437061, AI992344, AI351831, AA423954, AI655434, AA029186, AI421314, AI025154, AA905377, AI189632, AI148753, AI971532, T77225, T77438, T53640, AA889771, AA029185, and N27393. HNOAX12 330 969363 1-777 15-791 N59866, N22173, H24646, H27385, AL119324, AL119457, AL042544, AL119399, AL119464, AW392670, AL119443, U46349, AL119418, AL134902, Z99396, AL119444, U46351, AL119391, AL119363, AL042965, AL119319, AL119355, AL119483, AW372827, AW363220, U46350, U46347, AW384394, AL119439, AL119484, AL119497, AL119401, AL134538, AL119341, U46346, AL134536, U46341, AL134525, AL119335, AL037205, U46345, AL043019, AL042450, AL042984, AL042542, AL042614, AL042975, AL043029, AL119304, AL043003, AL042551, AP000473, AR066494, AR060234, AR054110, A81671, and AB026436. HNOBF57 331 927903 1-769 15-783 AI672348, AW173697, AL079990, AI565451, AW305215, AA115462, AW081450, AW020072, AA031780, AA115214, AI094153, AI610893, AI088661, AI051834, AA233114, AA115204, AI469307, AI970462, AI620951, AW130820, N69772, AA495921, N34679, AA987696, AA495922, AA115067, AI770044, AI079994, AA150297, AI434100, AW236674, AI039432, AA961227, AI873440, AA938897, AI681115, AA031879, AA603790, AI301357, N44611, AA243692, AA377521, AA910225, AI913596, AI702644, AA961701, AW452143, AI352693, AI381836, AI767254, AI247300, AI050072, AI830541, AI865675, AI493755, AA573940, AA937056, AI266405, AW138034, AA148788, AA653705, R37287, Z41281, AI090946, AI612953, AW103627, AA326653, AI572322, T49708, T49709, N85358, T49717, N84377, D25919, AP000300, AP000113, and AP000045. HNOCQ04 332 964933 1-686 15-700 AI717999, AW404782, AI831040, C15687, AW410719, AI634938, AI479751, AA723194, AA398997, AA455667, AW410718, AI589849, AA584383, AI130687, AI190201, AI525790, AI460181, W69759, AA456685, AA632185, AA456287, AI298115, R53507, AA644652, D45471, AI368832, AW300844, AI762742, AA976082, AA621626, AI912458, AA781178, AA292406, AA643693, AI814720, AA399628, AI351664, AA989507, AW408212, AA132709, F20423, AA292771, AA765663, AA417936, AA026022, AI282190, AA394242, AA586966, AI351631, AA620713, AA582000, AI708099, R55785, AI039470, AI498903, AA132838, AW406442, AA327225, AA777017, AA564894, AA635420, AI832846, AI203528, AI274498, AA774256, N71139, AA328719, AA418114, AA810589, AA303814, AI832934, T54206, AA084447, AA093329, AA720518, AA552845, D81168, AA304523, AA582959, AA298391, AA838663, AA765473, AA411181, AA187606, AW404897, AA411255, AI814800, AA025235, H80024, AW375226, AA651654, W01588, AW008079, AA405649, AI283769, AA384979, F25444, AI916435, AA776514, AW407879, AA308415, AA318663, AA081629, AW175606, AI569238, AI245051, AA758698, AI268159, AA707891, AI695095, T65944, AA394168, AA405650, R55866, W69865, T48798, D44876, and AF061177. HNOCT39 333 952611 1-101 15-115 AA806386, AI244963, AW069189, AA811454, AW069641, AA228016, AI926450, N20102, AA984503, AI283001, AI335808, AI022959, AI699076, AW008997, AI092767, AI358493, AI289652, AI309309, AA747446, AA521303, AI460092, AI354930, AW105294, AA902193, AI358182, AA975250, AA576719, AI766428, AI335889, AA071293, T10067, R58045, and AI355753. HNOCU05 334 957833 1-733 15-747 AW364014, AW364012, AW364015, AW364019, AI760785, AI267509, AI224905, R80458, N76465, AI384093, N59362, AA513728, AA729606, R80659, AI351352, AI499874, D61921, R69849, AA573139, R31977, and AB033047. HOCMU03 335 922418 1-602 15-616 HOCPJ03 336 917484 1-299 15-313 AW374051, AW374048, AW374059, AA047322, AA573420, AA873293, H50745, T67156, and AI718619. HODAD73 337 973463 1-490 15-504 AC004889. HODAD95 338 974043 1-577 15-591 Z93783. HODAG37 339 529410 1-224 15-238 HODAH32 340 859509 1-305 15-319 AA076906, and AC004976. HODAJ01 341 921666 1-570 15-584 HODAJ35 342 529405 1-325 15-339 AC005618. HODAK38 343 529404 1-310 15-324 HODAK95 344 960179 1-690 15-704 AI333350, AI522314, N93898, AI539488, AI276544, AW292555, AA194179, AA193323, AA621456, and N64007. HODAO16 345 529401 1-271 15-285 HODAT56 346 529402 1-354 15-368 HODAV80 347 859519 1-287 15-301 HODAW60 348 692684 1-315 15-329 HODAW84 349 775425 1-503 15-517 AI800919, AI741507, N21056, AA969954, AA669258, AI018174, AI243491, and AI342531. HODBC01 350 921662 1-290 15-304 HODBC07 351 954161 1-317 15-331 HODBE01 352 921655 1-102 15-116 HODBH16 353 927781 1-286 15-300 HODBO85 354 859559 1-156 15-170 HODBT58 355 678444 1-303 15-317 AA224807, AI355986, AI791718, C14330, AA778962, N94325, AA312559, H71678, H19817, AA483141, N41775, AW440368, W02497, AI824476, AA224917, H12857, AA747609, AI823705, AI925065, AI025930, AW088631, N68449, AW238253, N69399, AA610381, T54144, AI459943, AI282629, H40324, AA326904, W24312, AA088834, AA721545, R69819, AI246061, AA579152, AI434513, C06004, AI693979, AA993636, AI459904, H68343, AW176639, T94140, AI749893, R42902, AA742815, AA278496, AA550850, C14480, AW162227, N88725, H93152, R93919, AI306717, AA679353, C14557, AW023111, AA225627, AA135811, R92421, AI201474, AA614595, AI609972, AI446336, AI002928, AA622910, AI339725, AL042667, AL042670, N67810, AA648957, AW054936, AI054090, N27874, T40629, AA356310, AA857622, AA838091, AI133514, C18253, R89081, H25938, AA836548, AL041375, AW408767, AA135988, AI417586, AA199864, AA311376, AI445373, AI284543, AA804297, AI254770, N54397, AA730359, AI251944, AA558404, AI251034, AI251203, AI251284, AI250552, AW390309, H19851, AI207738, AA312115, AL096763, AC004841, AC003080, AC005399, AC005566, Z84487, AL096816, AC005082, AF045555, AL049776, AC004814, AC002310, AC004531, AC005736, AC004099, AC004448, AC004112, AL121603, AL049713, AC005632, AP000500, AC005520, AL024498, AC007225, AC005229, AC005081, AC004882, AP000311, AL031407, AC006312, AL049709, Z98048, AP000553, AC008040, AC006441, AC002059, AC005562, AC004129, Z93241, AL031665, AC005529, AC004685, AC007298, AC002070, AF030876, AL022326, AF001549, AC004552, AF111168, AC007199, AC006013, AC000120, U52112, AP000143, AP000555, AF165926, AL020997, AL035086, AC005180, AP000953, AL049779, AC005071, AC005015, Z98946, AC005011, AL031589, AC000026, Z97054, AL109627, AC006468, AC002301, AL022316, AC005844, AC003030, AC005482, AL049778, U07563, AF181897, AC003101, AC005189, AL023879, L78833, AF139813, AF002223, AL050307, AC004408, AL121657, U95742, AF053356, AC005839, AL020993, AC003956, AC005598, AC005846, AL049814, AF047825, AC006576, AL031680, AF001550, AL022476, AC006026, AL021917, AC007283, AC005899, AC007216, AL050348, AP000355, AC006976, AR036572, U91328, AC004999, AC005902, AC004638, AC007308, AF003626, AF126403, AC005531, AC002551, AL080243, AC004859, AC002470, AC003962, AC004125, AC005095, AC005207, AL031447, AC002350, AC004458, AC004988, AL049757, AL031666, AC002302, AL021578, AC000134, AC007546, AC005318, AC007707, AL122020, AC002044, AC006014, AC005519, U80017, AL031291, Z95114, AL133243, AC009516, AL031985, AC006536, AC004991, AP000952, AC005940, AC003108, AL034549, AL008582, AP000510, AJ251973, AC006208, AC008072, AC004551, AL031281, AF109907, AC005516, AL022238, AL133246, AC004983, AL121652, AC005722, AC002381, M89651, AC005751, AC002094, AL023803, AL136295, Y10196, AL117355, AC005049, AF111169, AC002531, AC005332, AC005005, AL049692, AC007934, AC004883, AC006960, AC002073, AC006285, AL034548, AL031255, AF205588, AC005911, AC007687, AC007193, Z93020, AF123462, AL031659, AL021878, U85195, AC002565, AL121825, AL022328, AC005288, AC004820, AC004854, AC005799, AL049631, AL049569, AP000503, AP000556, AC006430, AE000658, AP000552, AC004019, AL096791, AL049540, AL031685, AL133448, AL035495, AC004447, AC005214, AC006111, Z93244, AC006571, Z98304, AP000563, AC016831, AC003667, AC007226, Z92845, AP000116, AP000049, AC010205, and AC002530. HODBU95 356 529329 1-327 15-341 HODBV71 357 761447 1-330 15-344 AA115711. HODCAI1 358 967732 1-201 15-215 AC006977. HODCA68 359 529400 1-256 15-270 HODCD05 360 932218 1-767 15-781 AA393097, H60256, T97474, R08469, N52915, and AC000955. HODCH64 361 529327 1-111 15-125 AA480604, and AA420518. HODCJ11 362 967320 1-344 15-358 AI378046, HODCJ42 363 932638 1-324 15-338 HODCL88 364 529334 1-409 15-423 W94969, W93385, and H70278. HODCM62 365 859556 1-298 15-312 HODCO09 366 573202 1-343 15-357 HODCO46 367 573200 1-312 15-326 HODCO82 368 573195 1-321 15-335 HODCP69 369 507249 1-332 15-346 HODCR43 370 529332 1-422 15-436 Z57028, and Z57027. HODCT07 371 954149 1-303 15-317 AL035420. HODCU01 372 917270 1-358 15-372 HODCU02 373 920698 1-618 15-632 AC018633, and AC005271. HODCU62 374 524314 1-347 15-361 AI190063, AA661921, AA063173, AA635739, AA984295, AA613591, F34498, AA584739, AW168618, AI918465, AA322792, AA507547, AA559290, N35894, AA483204, T92797, AA630925, AI284640, AA644070, AI250083, AA362349, M86120, AA295742, AI433008, AF039185, W45625, AA769720, AW021735, F25199, H65170, AA661814, AI223604, AI816141, AA664700, D52587, AA484373, AA508359, AI674174, AA683283, M77986, AA747070, AA486131, AW084466, AA316905, AL042853, AA491814, AI002720, AA866015, M77865, AA309533, AA493695, AA099939, H53984, AW149313, AA493954, AA834707, AI494203, AI345157, AI687343, AI209074, AA279421, AA640635, AA515440, AA788990, AL041619, AA577824, AI471887, N71728, AA376120, AA324585, AI311684, AA838190, AI039584, AI700109, AI904219, N49368, T94317, AA502529, AW150635, AA358515, AL034417, Y14782, AC006205, AC002300, X06123, X61109, AC002094, AL132800, AL133500, AL136295, U18181, AC002565, AC004848, AC004882, AC005529, X14448, U78027, Y18000, U08988, A67988, AC006976, AL031255, Z96074, AC006115, Z94801, AF023268, AC006116, AC006007, AC004031, AC005952, AC005523, AC004953, AL009031, AC002326, AC005781, AL133312, AC007919, AL049692, AC003035, Y09781, AL022164, U62292, AL008730, AC007239, AD000684, AL049871, AC005902, U66059, AF114156, AC005512, Z83846, M61835, AC006356, AC007100, AJ006996, AL132712, AB023053, AP000517, AC006432, AC008044, AC002074, AC005280, AC002430, AC007384, X55923, D26141, AC005548, AL117356, Z98051, AL133241, U95742, Z84470, AC007216, AC005772, AC004385, AC007686, AF118885, AC002540, AC004069, AC007681, AC006026, AC004643, AL031577, AL035079, AL050306, AC005217, AC005245, AL033521, AC007242, AC006344, AC006965, AC002524, AL049198, M37547, Z13983, AL035402, AC004979, AL031729, AC007666, AL008638, AL049647, AC000052, AC004019, AF097026, AR036572, U91328, AC006120, AC005094, AC004920, AC007298, AL133448, AL121603, AL023284, K00063, AC003100, AC006239, AC009533, AL117342, AC004028, Z95400, AL021407, AC006322, AC005699, AC005342, AC006511, AC005754, J04809, AL034373, AC004987, AC005007, AP000459, AC004687, U85195, AC005998, AC005295, AP000470, AC004756, AL035694, AC005393, AC007011, AC005746, AC005837, AE000658, L49046, AP000150, AC005026, AC007099, D83989, U02531, X53549, M12523, I55948, AC005907, AC004034, AC004234, Z81369, AL079295, AL135746, AF123462, AL022322, AL078463, AC005046, M96868, AC002477, AL031722, AC006484, AP000299, AF039907, AC004221, AC005862, AC006077, AC004771, AC004030, AP000365, AL031678, AL031295, AP000548, AC006998, AC004033, AL110292, AC005500, AC004381, U57005, AC002395, AL096765, AP000009, AC010072, AF015151, AC005175, AL020996, Z78022, AC007043, AL031282, AC007541, AC005535, U18393, AC006486, AC004651, AF084195, AC004232, Z99129, L35930, AC002507, AP001136, AC005250, AB020874, U85196, AL008721, AF064861, U85198, AL035552, Z98200, AC010722, AL008718, AC006080, AL050308, AE000661, AC004066, Z82210, AC005058, AL024509, AR068368, X12751, AF001298, AL024496, AC004761, AC005525, AF002991, M63796, AC006537, AC008981, AC005253, AC005604, AC005387, AL121934, AC004940, AC008168, U69730, Z98046, AC004650, Z84482, and AL121591. HODCV09 375 973487 1-602 15-616 H01843, AA988637, AA487321, AI820602, AW068586, AI097301, AI279255, AA247291, AW138282, AA599014, AI862060, AF034209, AC005172, Z98304, AC005134, AL049744, AC005186, AL109622, AC001227, AC002101, AL021397, AC006362, AC008080, AL008730, AC000114, AC005375, AL021408, AC006568, AC007459, AC004552, AC005881, AL135784, AF003529, AL034350, AL049760, AC006963, AC006926, AC004915, AP000459, AC005070, AC006007, AL031121, AC004388, AC010722, AL023283, AL031779, AL121587, AC007688, and AJ011930. HODCW17 376 960051 1-337 15-351 HODCW37 377 575256 1-270 15-284 AL133353. HODCZ20 378 859580 1-342 15-356 AC007938. HODDD20 379 933726 1-219 15-233 HODDD41 380 529390 1-323 15-337 HODDE28 381 529169 1-355 15-369 AC008063. HODDF51 382 937759 1-255 15-269 HODDG57 383 806204 1-694 15-708 N69445. HODDH52 384 742217 1-487 15-501 AL040588. HODDM21 385 523270 1-236 15-250 HODDM25 386 780472 1-566 15-580 R06499. HODDM78 387 859516 1-357 15-371 HODDN40 388 859518 1-727 15-741 AA812474, AC012039, and Z98172. HODDN59 389 975437 1-646 15-660 HODDN93 390 891236 1-521 15-535 R22206, AI635500, AI769453, and AI743579. HODDQ02 391 920962 1-271 15-285 HODDQ21 392 919295 1-375 15-389 AA148171, AA136605, W86355, AA295674, AA320600, AA303426, AI391670, H79980, AI952411, AW000989, AI885634, AW450872, AW411085, W90311, AB018358, AB020712, AB018359, AF161393, AF161452, and AF034582. HODDR13 393 529640 1-202 15-216 U95122, AF073503, AF073502, AF073504, and AF073505. HODD567 394 567197 1-341 15-355 AW238853, T08054, N36319, AA191661, F13217, T57711, T75430, AL039920, H00125, T36199, R15057, AC007225, AF191298, and U47024. HODDU70 395 529290 1-344 15-358 AC002075. HODDX35 396 531209 1-312 15-326 HODEA90 397 782242 1-675 15-689 HODEB04 398 927022 1-356 15-370 AF011889. HODEC76 399 952204 1-599 15-613 HODED11 400 966085 1-525 15-539 HODBD55 401 859368 1-595 15-609 HODED87 402 915909 1-1433 15-1447 AI290807, AA843195, AI924510, AW205119, AI348581, AI337545, H82747, N33608, AI810344, AI970945, H83622, AI873082, AI690115, AI199002, AW296637, AA600866, AA928078, N49452, AI468390, AA371877, AI204414, AI628721, AI092558, AI309751, and AI692784. HODEF10 403 963494 1-595 15-609 D80188, D59859, C14389, D59927, D58283, D81030, D51799, D80253, D80166, D80043, D51423, D59619, D80210, D80240, D80212, D80391, D59787, D50979, D80227, D80022, C14331, D80219, D80195, D80196, D59467, D80164, D59275, D80366, D59502, D57483, D59610, D59889, AA514188, D81026, AA305409, D80248, D80024, D80269, AA305578, C15076, D30522, D80045, D80038, C14014, D51022, D50995, D80193, D80251, D80378, AA514186, D80241, D51060, AW360811, D80133, AW177440, D80268, C14429, AW178893, AW375405, C75259, T03269, D80247, AW179328, AW360844, AW366296, AW377671, AW360817, AW375406, D80439, AW378534, AW179332, AW377672, AW179023, AW178905, C05695, D80302, AW378532, D80134, AW177501, AW177511, AW352171, D58253, AW377676, AW352170, D80132, AW177731, AW178907, AW178906, D51759, AW178762, AW179019, AW179024, D59373, D51250, AW177505, AW360841, AW179020, AW178775, AW178909, AW177456, T11417, AW369651, AW179329, AW178980, D80157, AW177733, AW378528, AW178908, AW178754, AW179018, AW352158, D51079, AW352117, AW176467, AW352174, D51103, AW367967, AW179004, F13647, AW179012, AW178914, D80949, AW378525, D52291, D80064, AI910186, C14227, D80168, AW177728, AW179009, D58246, D81111, AW178774, AW178911, AW378543, AW177722, AW352163, C14298, AW178983, T48593, AI905856, C14407, D59653, AW178781, C06015, D59503, D45260, AW352120, D58101, AW360834, AW177723, AW378540, Z21582, D59474, D59627, D80258, H67854, AA809122, AW367950, AW378533, C03092, H67866, AW177508, AI535850, AA514184, D45273, AI525923, AA285331, D80228, AI525917, AW178986, AW177497, D51213, D51097, C14957, AI525912, D80014, D51221, T03116, D59317, D60010, C14973, AW177734, AI525920, C14344, AI557751, D50981, AI525227, AI535686, D59551, AI525235, C14046, D60214, AI557774, T03048, AI525222, C16955, AI525215, AI525242, AW378542, AI525925, AW378539, C05763, Z33452, T02974, D31458, AI525237, AW360855, D51053, H67858, C04682, AF053356, AR008278, A62298, AR018138, AB028859, AJ132110, A84916, A62300, AF058696, X67155, Y17188, D26022, Y12724, A25909, A67220, D89785, A78862, D34614, A82595, A94995, D88547, AB002449, AR060385, AR016808, AR008443, X82626, I50126, I50132, I50128, I50133, AR025207, AR066488, AR016514, AR060138 A45456, A26615, AR052274, Y09669, A43192, A43190, AR038669, AR066490, AR066487, A30438, I18367, AR054175, I14842, D50010, Y17187, AB012117, AR008277, AR008281, A63261, AR008408, X68127, AR062872, A70867, AR016691, AR016690, U46128, A85396, D88507, AR066482, A44171, A85477, D13509, I19525, A64136, A68321, A86792, AR060133, I79511, X93549, U79457, AF123263, AR032065, X72378, and AR008382. HODEF87 404 974342 1-617 15-631 C14389, D59859, D80195, D80043, D80188, D80166, D51799, D51423, D59619, D80210, D80240, D80253, D81030, D80164, D58283, D80193, AA305409, D80212, D80022, C14331, D80024, D80219, D59467, D80391, D59275, D59889, D59787, D80227, D59502, D57483, D80366, D80196, C15076, D51060, D59927, D59610, D80269, D80038, D50979, D50995, D80045, D80378, C14014, D80241, C14429, D51022, AA305578, AW177440, D80248, AW179328, T03269, C75259, AW178893, AA514186, D81026, D80251, AW378532, AA514188, D80134, D80522, D80133, AW360811, AW178762, AW178775, D58253, D51250, F13647, AW369651, AW375405, AW177501, AW177511, D80268, D51111, C05695, D52291, D51079, AW377671, AW366296, D80949, AW360844, AW352158, AW360817, AW375406, AW378534, AW179332, AW377672, AW179023, AW178905, D80302, AI910186, AW352117, AW176467, D80439, D80168, AW377676, D80064, Z21582, C14298, C14227, AW352171, D80132, AW352170, AW177731, AW178907, AW179019, AW179024, D59373, D80247, AI905856, AW177505, AW178906, AW179020, AW360841, AW178909, AW177456, C06015, AW179329, C14407, AW178980, AW177733, AW352174, AW378528, AW178908, AW178754, AW179018, T11417, AW378540, D51759, AW179004, D80157, AW179012, AW178914, AW378525, D51103, AW367967, AW177728, AW179009, D58246, AW178774, AW178911, AW378543, AW177722, AW352163, AW360834, AA285331, AW178983, D51097, AW178781, AI557751, T48593, D59503, AI525923, AW352120, A62298, AJ132110, AR018138, A84916, A62300, AR008278, AB028859, AF058696, X67155, Y17188, D26022, A25909, D89785, A67220, A78862, and D34614. HODEG86 405 784833 1-634 15-648 HODEH08 406 963895 1-129 15-143 AA370640, AW248314, AA371439, AA344067, AA370162, D31255, AA340719, AA331358, AW248978, AA488592, AW406647, W44489, AI083656, AA358813, AA360045, T97410, R07253, AI582770, H29999, Z59378, Z64078, Z64079, and Z54696. HODEH22 407 974329 1-411 15-425 HODEI13 408 859318 1-599 15-613 HODE148 409 841906 1-660 15-674 HODEK50 410 859307 1-728 15-742 AC007075, AC007226, AL080243, AC004967, AC002352, U91321, AC006275, AC002551, AC005519, AC004832, AF196779, AD001527, AC002404, AC005089, AC005952, AC005280, AC003684, AL031431, and AC005972. HODEL92 411 859313 1-252 15-266 HODEN75 412 772940 1-579 15-593 AW339014, and AC005630. HODE087 413 930735 1-164 15-178 HODEP04 414 926984 1-585 15-599 AA317093. HODEP12 415 965534 1-427 15-441 HODEP86 416 784846 1-404 15-418 HODEQ28 417 972808 1-438 15-452 HODEQ79 418 859287 1-516 15-530 AB033061. HODER91 419 789661 1-338 15-352 AA233995, and AB033047. HODE586 420 784815 1-920 15-934 AA063018, AA063458, AI444822, AA666066, T94072, C15362, AA890123, AW190277, N54301, AI866580, AA363003, AI277783, AI018726, AA368329, AA366676, AA329535, AA078184, AL119028, AI926296, H60331, AW243945, AW083934, AA504951, AA702637, AI054414, AW162303, AA584207, AW089016, AW162047, AI818702, AW270429, AA341865, M86102, C15811, AW161786, AA577824, AW270351, AA501781, AL037632, AI904944, AI224619, AL118912, AI369076, AI268019, R56349, AI654520, AI565084, AI246061, AA356376, AI432298, AA552724, R98835, AI130709, AI536858, AI537995, AA508882, AI278847, AA626840, AA773473, AW051819, AA339789, AA302982, AW069227, AW272640, AW148775, AI668566, AI814682, AA326904, AI291439, AI720403, T62078, AI873627, AA504892, AW337526, AA910941, AA365318, R44855, AW381816, AA126271, AI634187, AA904211, AA626595, AA745628, AI354330, AI381490, AI457313, AA827383, AW132065, AA513189, AA827875, AI357109, AA632556, AA604149, AL134418, AA078137, AI247101, H13120, AI125615, AA314338, AA362440, AW236288, AA888638, T02817, AI251968, AI251976, AI308598, H27788, AI254673, AI246059, AI255003, AI241970, AI223508, AI254658, AI252933, AI251598, AI251298, AI251380, AI254937, AA628740, H65697, H65213, AW337483, AI049630, H03243, T06485, AI521042, AA297776, AI679045, AA525517, H73550, AA351893, AA297496, AA721523, AA721530, AA380781, AA101264, AA564714, AA362569, AI254798, AI199816, AA378195, AA937687, AA584525, AA572813, T06876, AI831172, AW103395, AI284684, AI252207, AA862312, AI270149, N54179, U02047, AC004531, AC004382, AP000116, X58139, AC007114, AP000310, AP000547, AC004646, AC005242, Z94161, AC004644, U89336, AL049650, AC006057, AF139813, AC007023, AC005899, U77079, U77081, AC000061, AC003110, AC006450, AF015416, AL133289, AC004552, AC008103, Z98051, AC004834, AL132712, AP000513, Z98745, AC005320, AC006482, AL049591, X96421, AC007325, AC004228, AC005778, Z73963, U77080, U77078, AL049829, AC004494, Z84487, AF196969, L22968, AC005678, AC005544, AC004999, AL022323, AC004585, AC006441, AC005224, AC006277, AL022728, Z68872, AC005399, AC005175, AC004551, AC011422, AF111168, AP000260, AC006084, Z68756, AC005237, AC000003, AC006430, Z84497, AC002375, AC002352, AL133448, AC006049, AC004832, AC005632, U69641, AC003689, AF053356, Z98044, AL035405, AL096767, AL023513, AC004841, AC002312, AF196779, AP001053, AC004998, AL024507, Z84719, AL034423, AC007204, AC003109, AL023807, Z99291, D89927, AL031984, AL031776, AC008044, AC005232, AC002504, AC002425, AF030453, AF196971, AC004217, AC003682, U85195, AC002325, AL132774, AB023049, AP001056, U73644, AC004263, AC002384, AC005872, AL022313, AC008055, AC004820, AE000658, AC003080, AD001502, AC006312, AC009784, AC004782, AL031667, AC003107, AC000052, AC007015, AC006251, AC005338, AC004988, AC007314, Z82190, AC000379, AC006285, AC005666, AC006947, AL078581, AC004253, U91323, AP001137, AP000099, AC002314, AL008712, AL035703, AC007057, AC000118, AL133396, AC006543, AC005514, AC004876, Z83845, AC007666, AF038458, AC005180, AL135960, AJ131016, X82877, AL031736, AC004815, AC004882, AL035450, AL008718, AL049776, Z98200, AL022144, U91327, L47234, AC006948, AC005351, Z93244, AC006075, AL034555, AL049636, AC006544, Z97030, AL009183, AC005372, Z95115, M25828, Z70289, AP000690, AC005565, AL020997, AC007687, AC006051, AL031427, AC003030, X94652, AC002996, AL021307, AC004492, AC005620, AC002347, 548539, AC003663, AC009363, AP000952, AC006474, AC006241, AC004905, AC005049, AL031602, Z93024, AC005274, D86995, AC007182, Z54246, AF001550, AC004865, AC002365, AC005820, AL031315, AC005562, AP000023, AC005070, Z81357, AC006538, AC005014, AC004796, AC002369, AC005771, AC002302, AC007124, AF073485, AP000055, AP000170, AF015720, AF146367, AC004890, AL031005, AL133163, AP000036, AC006561, AL109847, Z82215, U07562, AC006065, AL109939, and AC007065. HODET03 421 922988 1-485 15-499 HODEV13 422 859302 1-756 15-770 HODEX10 423 926260 1-373 15-387 HODBX31 424 922473 1-512 15-526 HODEY08 425 972984 1-1100 15-1114 AI084273, AA573804, AI131332, AI597908, AW166900, AA335039, AA826556, AA451989, AA286811, AA953404, AW075574, AA605285, AA919038, AA701491, AW086028, AI565546, AA885214, AI248960, AA884815, and AA974731. HODEY13 426 859323 1-686 15-700 HODEY80 427 859296 1-873 15-887 AL049821. HODEZ02 428 918672 1-208 15-222 HODEZ11 429 952166 1-431 15-445 AF195658, AL049780, and AC006530. HODFA38 430 934266 1-627 15-641 AA570447. HODFB05 431 929733 1-627 15-641 HODFB57 432 972810 1-641 15-655 HODFB88 433 792979 1-620 15-634 AA381448, AA381591, AA307619, and U46407. HODFD08 434 958371 1-383 15-397 HODFD10 435 963516 1-560 15-574 HODFD45 436 780531 1-387 15-401 AC009263. HODFE69 437 859338 1-288 15-302 HODFG37 438 782219 1-523 15-537 AL009031, and AC002326. HODFH02 439 915257 1-280 15-294 HODFH76 440 783783 1-521 15-535 HODFJ01 441 859549 1-488 15-502 HODFK18 442 974313 1-728 15-742 AW194418, and AI859957. HODFK94 443 974318 1-635 15-649 HODFL91 444 918456 1-517 15-531 AL009031, and AC002326. HODFN19 445 859334 1-507 15-521 AI498226, AI468496, AI675849, AA411880, U95626, AL022334, AC005234, AC002524, AC006031, L47334, AL049594, and AC005011. HODFN42 446 921529 1-304 15-318 AI670069, and AA934600. HODFO03 447 859329 1-297 15-311 AC002044. HODF037 448 859314 1-530 15-544 AI669554, AA854975, AI016754, AA024782, and AA009958. HODFP40 449 921651 1-902 15-916 AW195474, AI754576, AI301859, AA846702, and AC004889. HODFQ02 450 918637 1-601 15-615 HODFQ06 451 934304 1-524 15-538 AI523074, AI709307, AI284105, AA904211, AI271762, AI735609, AW270258, AI031759, AW082076, AA515351, AW083934, AA744227, AA713765, AI955029, Z33592, AA478602, AW028376, AA744094, AA548692, AI492579, AI267356, AA297496, AA493628, AA912287, AI431513, AA492524, AI247101, AI061313, AI267450, AI613389, AI311796, AA657374, AI281818, AW274078, AW303196, AW274349, AI348597, AI889579, AW272640, AW089016, AA604831, H52283, AA837642, AA827383, AA744048, T49184, AI253376, AC005815, AC008132, AC007981, AC012330, AP000550, AC008018, AC007324, AC007325, AC009288, AP000552, AC007664, AC007708, AC009399, AC007917, AL034419, AC005209, AP000511, AL050341, AL035681, AL022329, AC004832, AF205588, AC004019, AC005250, 134294, AF030453, Z97054, AC005837, AL139054, AC005529, AC004525, AC005519, AC007450, AL049712, AC007225, AL031594, AC004675, AL121825, AC010205, AL031311, Z81366, AF088219, AL117354, AC005740, AC005102, AC005089, AL133448, AC002312, AC005037, AL049631, AL024498, AC003043, Z85987, AC006443, AC005914, AC005399, AC005081, AC004893, AC006538, AC005800, AL049569, AL117352, AL135744, AC005881, AC006241, AC016027, AC006126, AC004757, AL022313, AP000257, AC006501, AC006014, AC005527, AL049759, AC006430, AC006285, AC004878, AC008101, AP000501, AL121757, AL034417, AL008726, AL035685, M90058, AP000512, AP000704, AC005901, AC004884, AL031670, AC004491, AC006511, U80017, AL034418, Z97630, AL078463, AC005231, AL035462, AF207550, AC005488, Z98051, AL133382, AF053356, AL022316, AF092858, AC005940, AP000355, AC008038, AC005015, AB003151, AC006536, AC005920, AC004167, AC003101, Z97056, AC007057, AC005962, AC002316, M84371, AP000347, AL031681, AL022238, Z94801, AP001054, AC005736, AL031282, AP000098, AL133353, Z75741, AC002128, AL008582, AC005695, AC016830, Z85986, U96629, AC002039, AL132857, AC005220, AP000694, AL121658, AC004752, AF017104, AF045555, AL031602, AC007546, AC005088, AC002301, AP000557, AC004992, AC004659, Z82190, AL031662, AC016025, AC002401, AC004655, AC016831, Z69705, AC007406, AC006121, AC005755, AC002369, AC006211, Z98946, AC005730, AC002352, AC004662, AB023049, Z84466, AD000091, AC005031, AD000092, AC002470, AP000692, AL020995, AC009247, AC004653, AC004754, AC004859, AL031776, AC002115, AC018769, AP000348, Z83846, AC004139, AL020997, AL034369, AC003982, U34879, AC005300, AC003991, AC006064, AF111167, AC009510, AL133246, AL049758, AC002310, AC004531, AC005360, AB023051, AP000252, AL033527, AP000504, AC005697, AL096701, AC005793, AC002351, AC002073, AC007227, AC002551, AB016897, AC006125, AC006449, AL031667, AC002350, AC004587, AF134726, AC007298, AL008583, U91326, AC007993, AL109839, AC007536, AC007637, AL078581, AC006101, Z94056, AC005162, AL022315, AL121653, AC005005, AC005316, AC005874, AF134471, AC004953, AC006071, AC005726, AL022237, AL079342, AP000212, AP000134, AC004685, and AC005768. HODFT52 452 915232 1-789 15-803 HODFU02 453 918536 1-386 15-400 HODFU06 454 934229 1-625 15-639 Z68868. HODFU47 455 806232 1-641 15-655 AW265148. HODFU54 456 965526 1-123 15-137 HODFW17 457 859322 1-599 15-613 AW008635, AC018633, and AC005271. HODFX57 458 975259 1-407 15-421 HODFY16 459 958329 1-776 15-790 AA262613. HODFY79 460 975253 1-525 15-539 HODFZ11 461 965104 1-349 15-363 HODGC04 462 926863 1-201 15-215 AC019014. HODGC61 463 973449 1-512 15-526 HODGD05 464 931071 1-135 15-149 HODGH02 465 917969 1-626 15-640 D80164, C14389, D80227, D59467, C15076, D50979, D80269, D80195, D59275, D59502, D58283, D51799, D59859, D80022, C14331, D80166, D80043, D51423, D59619, D81030, D80210, D80391, D80240, D80253, D59787, D59610, D80188, D80038, D80378, D80212, D80193, D80196, D80219, D59927, D57483, AA305409, D80366, D59889, D50995, D80024, D80241, AW177440, AA305578, D80045, C14429, D51022, D51060, T03269, D81026, AW178893, AW378532, AA514188, C75259, C14014, D80251, D80248, AW179328, D80522, D59695, D80134, D52291, D51250, AW369651, AW178775, D58253, AW177501, AW177511, AW178762, AW176467, F13647, AA514186, D80133, AW360811, AW352117, AW352158, C05695, D80168, AW375405, AW377671, C14298, D80268, AI910186, AW179332, AW378540, D80132, AW366296, AW360844, AW360817, AW375406, AW378534, AW377672, AW179023, AW178905, AI905856, D80302, AW378528, D59373, D51103, AW352171, Z21582, D80439, AW377676, AW178906, AW352170, AW177731, AW178907, AW179019, AW179024, D80247, T11417, AW179329, AW177505, AW179020, AW360841, AW378543, AW178909, AW177456, AW360834, AW178980, AW177733, AW352174, AW178908, AW178754, AW179018, AW378525, D59627, AI557751, AW179004, AA285331, AW179012, AW178914, D51097, AW367967, D80157, AW177722, AW177728, D51759, AI535850, AW179009, AW178774, AW178911, AW352163, C06015, D58246, D59503, AW178983, AW352120, AW178781, T48593, D80258, D58101, AW177723, AI525923, D80014, D59653, AW378533, AW177508, D45260, D51213, AA809122, C14975, C03092, AW367950, D59317, H67854, AI557774, H67866, D59551, AW177497, AW178986, T03116, D80064, D45273, D81111, AI525227, D51221, AW177734, AI525925, AA514184, AI525917, C14227, C14973, AW378539, C14344, AI535686, T02974, D60010, D59474, AI525920, C14407, D60214, AW378542, AI535961, C14957, C14046, T03048, AI525242, AI525235, AI525912, D31458, AI525215, C16955, AW300744, C05763, Z33452, AI525237, AI525222, AW360855, AJ132110, A84916, A62300, A62298, AR018138, AB028859, AF058696, X67155, Y17188, D26022, A25909, AR008278, A67220, D89785, A78862, D34614, AC007860, D88547, I82448, X82626, Y12724, AR025207, A82595, AR060385, A94995, AB002449, AR016808, AR008443, AB012117, X68127, I50126, I50132, I50128, I50133, A85396, AR066482, A44171, AR066488, AR016514, A85477, I19525, A86792, AR060138, A45456, A26615, AR052274, U87250, X93549, Y09669, A43192, A43190, AR038669, AR066490, AR066487, I14842, A30438, AR054175, I18367, D88507, D50010, Y17187, A63261, X64588, AR008277, AR008281, AR008408, AR062872, A70867, AR016691, AR016690, U46128, AF135125, I79511, D13509, A64136, A68321, AR060133, U79457, AF123263, AB033111, AR032065, AR060382, AR064240, X93535, and AR008382. HODGH04 466 926255 1-617 15-631 C14389, D58283, D80043, D80391, D59787, D80253, D80196, D59467, D51022, D80366, D80188, D59859, D80022, C14331, D80166, D80195, D51423, D59619, D80210, D51799, D80164, D59275, D80240, D81030, D80227, D59927, D59502, D50995, D50979, D80212, D57483, D80219, C15076, D80269, D59610, D80038, AW177440, AA305409, D59889, D80193, D80024, AA305578, D80378, D80522, D80241, D81026, D51060, C14429, D80045, AW178893, C75259, D80251, AW179328, T03269, D80248, AA514188, AW378532, C14014, AW177501, AW177511, AA514186, D80133, AW360811, AW178762, D58253, D51250, D80134, AW377671, AW178775, F13647, D80132, C05695, AW176467, AW369651, AW375405, T11417, D80268, AW352117, AI910186, AW179024, AW352158, AW366296, D80168, AW360844, AW360817, AW375406, AW378534, AW179332, AW377672, AW179023, AW178905, D52291, D80247, D80302, AW352171, D80439, AW377676, AW178906, AW352170, AW177731, AW178907, AW179019, AW179018, D59373, AI905856, AW177505, C14407, AW179020, AW360841, AW378528, AW178909, AW177456, AW179329, AW178980, AW177733, AW178908, AW178754, AW352174, AW378540, AW360834, AW378525, AW179004, AW179012, AW178914, D51103, Z21582, AW367967, D80157, AW177722, AW177728, AW378543, AA809122, D51759, AW179009, AW178774, AW178911, AW352163, D59627, D58246, AW352120, AA285331, AW178983, C06015, D51097, AW178781, D59503, T48593, D58101, D80258, AI557751, D80014, AW177723, D59653, H67866, D51213, AW177508, AI535850, D45260, AW378533, C14975, AW367950, H67854, C03092, C14227, AW177497, D60010, AI525923, AW178986, D80064, D59474, C14973, D81111, AI525227, C14957, AW177734, T03116, AI525917, D59317, 102974, D45273, C14344, D51221, D50981, AI525920, AA514184, AI557774, AI535686, AI535961, D59551, C14046, D60214, AI525912, C04682, AI525235, T03048, AW378542, C16955, H67858, AW378539, AI525242, AI525925, Z33452, AI525215, C05763, AI525222, AW360855, AI525237, C14298, AJ132110, AR018138, A84916, A62300, A62298, AB028859, AR008278, AF058696, X67155, Y17188, D26022, A25909, A67220, D89785, A78862, D34614, D88547, Y12724, X82626, AR016808, AR025207, A82595, AB002449, A94995, AR060385, AR008443, I50126, I50132, I50128, I50133, AB012117, AR066488, AR016514, AR060138, A45456, A26615, AR052274, X68127, Y09669, A85396, A43192, A43190, AR038669, AR066482, AR066490, A44171, AR066487, A85477, A30438, I19525, A86792, I18367, D88507, I14842, AR054175, X93549, D50010, Y17187, A63261, AR008277, AR008281, X64588, AR008408, AR062872, A70867, AR016691, AR016690, U46128, D13509, A64136, A68321, AR060133, I79511, AF135125, U79457, AF123263, X72378, AR032065, and AR008382. HODGH07 467 951933 1-538 15-552 AI686005, and AI658703. HODGH11 468 965105 1-631 15-645 AL050320. HODGH91 469 968794 1-527 15-541 AL033547. HODGI08 470 958235 1-253 15-267 HODGJ67 471 974297 1-520 15-534 HODGL54 472 859303 1-686 15-700 AI701008. HODGM46 473 974051 1-1000 15-1014 AW407007, AI125143, AA847341, AL044966, AA837771, AA582746, AA557945, AA610255, AA368329, AI732911, F35684, AA579082, AA522864, R67701, AI459879, AA635150, AI633386, F26395, AW021674, AW028376, AI468993, F00937, AA846046, AA640563, AW304580, AI25 1024, AA354868, AA158549, AI370470, AW275432, AI445699, AI538404, AA507990, AA219166, AI308529, H47461, W69639, AA825954, AI367551, W45215, AA610644, AA015948, AW407679, AA506734, AI636734, AI572680, AA507291, AA351868, AA569206, AI246386, AA368659, R79396, AA935827, AW238016, AA578245, AL135490, AW196288, AI828721, AI520984, AA661590, AW029626, W45416, AA460786, AI355246, H29914, H68343, AI921765, AA155817, AA219349, F16409, AI475611, AI888050, H79277, AI884404, AA706202, AW023975, AI281622, AW162314, AA468458, F34151, AL079894, AA804694, T03928, AA132445, AI567676, AI114494, AI245693, AA664963, AI434103, AA349016, AW162332, AA362440, AA831919, AA557790, AA225630, N66744, AI619727, AA582374, AA828834, AA778580, AA650528, AA719523, AI250552, T40838, AI251034, AI254770, AI284543, AA664126, AI350189, AI054090, AA715508, AA714011, AA385094, H78984, AW020682, AA176476, AA828840, AW023390, AI925588, AI733717, AI523356, AW151015, Z36862, AI337612, AI564209, F24745, AA364147, T94394, AL134940, T05617, W27084, AI053978, AW407889, AA226532, T15890, T40853, AI251284, AI251203, AI193417, AI223626, AW020150, H81406, AA358531, AA749196, AI537368, AI249853, AI221027, AA599423, AI963816, AI702049, AI339725, AI694154, AI246061, T50676, F34157, AI348780, AC004253, AC005913, U47924, AL109952, AC007201, Z85987, AC004587, AC004973, AL031447, AL022578, AC005067, AC007030, AL049735, AC007204, AC007285, AC003109, AP000692, AC005914, AC002369, AL133163, AC007637, AD000864, AC005971, AC007792, AC007193, AC004079, AC005726, Z82201, AC005021, AC005015, AC008929, AC006539, AC005317, Z84466, AF031078, AC004264, AC002126, AF030876, AC005197, AC004598, AL035450, AL110122, AC006597, AC004796, AC002091, AC007390, AL133245, AB017602, AL022313, AC004491, AL031666, Z81364, Z82248, AC005800, AC002549, AL117354, AL021407, AL034420, AC003041, AC002077, AC006071, AC004106, AC005291, AP000502, AL049761, AP000696, U73634, AL049869, AL049776, AC005214, AL117258, AC005566, AC005765, AL008724, AC003030, AC000159, AL033538, AC004881, AC007395, AC004895, AC004812, AC002107, AL008712, AL035422, AL031848, Z98950, AC005746, AC007371, AC005531, AC005046, AF139813, AC005793, AL031904, AC005900, AL135783, AC007277, AL133353, AC006581, AC005887, AC000004, AL121852, AL034417, AP000511, AC006130, M87912, AC000082, AC004844, AC005601, AC004228, AL031258, AC005696, AP000116, AC005921, AL122020, AC002350, AC003692, AC004762, AF146024, AC006531, Z97630, AL049591, AL049729, AC004042, AC002302, AC006163, AC004859, Z85996, AL049872, AL022336, AC005736, AF064019, AL049610, AC006275, AC006222, AC000353, AF217403, Z68165, AC005763, D87018, AP000268, AP000103, AP000033, Z85999, AC004706, AC002073, AC007993, AL078463, AL022721, U91318, AP000089, AP000142, AL049759, AL121915, Z93020, AC003025, AC006561, AL080245, Z98750, AL118516, AP000503, AL133312, AC005832, AJ243213, AP000952, Y18762, AL049839, AC004904, AC005940, AC005081, Z95118, Z93017, AC007225, AC005952, AL022311, AC005962, Z97633, AC004843, AC005859, AP000008, AP000704, AC006287, AL008707, AC006014, AC006077, AC004408, AP000243, AP000203, AF196972, AC006251, AL034548, AC007376, D87675, K00061, AL049611, AC002463, AL050308, Z83848, AL031685, AL050348, AP000030, AC004522, AL110200, AC016025, AC005288, Z95116, AL035587, AC005697, AL031733, AL024498, AC004616, AC006946, AC002418, AL034423, AC003029, AC003098, AL022331, AL023575, AC005532, AL096702, AL035659, AC006057, U02052, AC003969, U52427, AC005828, AL031433, AL096757, AL049838, AL031291, AL035249, AC005072, AL021154, AL035420, L78810, U52112, AL136363, AL031803, AC007388, AL135879, AL121790, U29953, AL024494, Z78021, AC004156, AP001063, AC005379, AC005775, and AC005074. HODGO46 474 883087 1-599 15-613 HODGP37 475 974293 1-552 15-566 AF152364. HODGP83 476 889967 1-223 15-237 HODGP95 477 908650 1-345 15-359 AC005189. HODGQ08 478 958237 1-390 15-404 HODGQ22 479 974290 1-527 15-541 HODGQ32 480 974294 1-658 15-672 HODGQ92 481 894368 1-392 15-406 AW369682, and AB018255. HODGT62 482 974052 1-547 15-561 HODGW08 483 958277 1-553 15-567 HODGX10 484 963427 1-313 15-327 Z84478. HODGX29 485 913879 1-256 15-270 AC006017. HODGZ06 486 933783 1-488 15-502 AC007685, and AC007284. HODGZ10 487 961977 1-460 15-474 HODHC03 488 922987 1-597 15-611 AI284176, AI907957, and U73642. HODHD16 489 974924 1-477 15-491 AI557250. HODHG71 490 926203 1-533 15-547 HODHH82 491 964935 1-316 15-330 AA002213. HODHI07 492 952195 1-629 15-643 HODHI26 493 973423 1-537 15-551 HODHK02 494 918613 1-289 15-303 HODHL19 495 973433 1-588 15-602 AC005083. HODHL56 496 847724 1-636 15-650 AA398482, and T63250. HODH011 497 965529 1-270 15-284 HODH534 498 965460 1-497 15-511 HODHY53 499 914554 1-663 15-677 HODJR03 500 922484 1-537 15-551 AC004804. HODJY33 501 951404 1-609 15-623 H04619, AW089973, AW002729, AA584259, AI147246, AA196770, and AC007279. HODJZ90 502 965049 1-250 15-264 HODKN07 503 933320 1-620 15-634 L44297. HOFAA15 504 659522 1-422 15-436 HOFAB40 505 964113 1-543 15-557 AA825531, AA604776, AI245442, AI188441, AI244061, AI753232, AI571537, AW022503, AI222789, AA679606, R40840, AA528442, AI753812, R44539, AI972757, AI095711, AI818331, AW193103, AI479622, AI984270, AI206770, AW188420, AI568325, AI282612, AI127300, AI085566, AI457985, AI273179, and AF095728. HOFAB71 506 573337 1-365 15-379 HOFAD05 507 932211 1-294 15-308 HOFAE31 508 772992 1-208 15-222 AI718967, AI066500, AI191408, AA970891, W16766, AI074219, F25014, N45385, AA465517, AA602119, N94010, F32882, F26209, F25830, N98860, AI934901, N77808, AA528414, AI338326, AW088372, AW102799, AA320204, AA768215, AI151192, AW419435, AA788658, AI150785, C03969, AI302844, AA725287, AL038871, AI350125, AI568272, AA983392, AA525200, AA977031, AI093521, AI580262, AI720008, H97078, AI313204, AI626036, AA526171, AA877563, AI144433, AA934574, AI079769, AA573686, AA639915, AA574008, AA976783, T51767, AA492272, AI189510, AI281422, W70094, AI926973, AA845331, N75412, AI279463, AA568387, AI201886, AA526497, AW084218, W05113, AI626023, AA315135, AI417313, AA642788, AW192600, AW102964, AA894481, AA737308, AA872663, H93685, AI440105, AI187012, AA829129, AA609288, AA760958, AI187043, AA448150, AI205981, N94451, R77045, AI187001, AA578537, AA181352, R76883, H20456, AI219168, AA614765, AI185992, AA738347, AA708433, F29053, AI984516, AA492189, AI869280, R83917, W30797, AA503282, AA781308, AI301663, AA782226, AA448007, H94367, AA771978, AA844201, AA134082, AI984517, AA782267, AA843941, AA928994, AI205979, AA732966, AA508863, AA349148, AW161501, AI815573, AI816249, AI027040, AA962040, AA373789, AI336883, AA081960, AW082030, AA132228, AA047332, N88037, AW156995, F20253, AI565512, AI041418, AA662040, AW078808, AI818057, AA484511, AA093070, AI581654, AI582679, AI097353, AA171667, AA315167, AA188617, W39735, AI469808, AI364733, AA602974, AI266413, F37845, AA365505, AA132332, AI720272, AA885755, AW071223, W03821, F27365, AW238838, N85440, AA305795, F26565, AA026450, AA082027, H45296, AA188736, AA573675, H49316, N88105, W24397, N88030, AA090865, M36647, Y00764, and 561826. HOFAE61 509 707359 1-372 15-386 AI694793, AW328387, AA287690, AW166132, AI701814, AI393309, AW005351, AI807923, AA304908, AA194090, AI799077, AI916382, AI131240, AI630546, AA308513, AW087574, AI138878, AA855025, AI188081, AW300307, AW340414, and R01958. HOFAF84 510 868887 1-352 15-366 HOFMA24 511 782275 1-333 15-347 R06046, N24376, AA431932, H96741, AI632470, AW130380, AW197748, AI183539, and AB032969 HOFMB78 512 572941 1-386 15-400 AJ388527, M21456, and X54067. HOFMB83 513 572839 1-343 15-357 HOFMD13 514 916959 1-393 15-407 HOFMB41 515 867993 1-354 15-368 X52381, AF163863, M64428, X56219, AF076492, and X56223. HOFMF03 516 924679 1-434 15-448 HOFMF70 517 734917 1-374 15-388 AA078777, AW205164, M59936, AF099730, AJ004856, and AF052692. HOFMG21 518 973358 1-485 15-499 AI870389, AI870412, AA443366, AI766675, AI304388, AA669930, W72592, W76106, N34142, AA446942, AI203601, AI021941, AI304344, W88877, AA703026, N21316, AI144379, AI499002, AA081147, AA906273, AI346611, N42641, AI525737, AA865339, AW005448, N46027, AA733097, W67866, AA894580, N41872, N40396, N31251, H70758, AW172490, W35238, AI311556, H95094, AA907108, AA860195, AA890706, AI688154, AI192484, AA516363, AI288868, W80864, AA774581, AL038165, AA193154, AA908255, W67811, AA676415, N67021, AA393462, N56626, AA075113, W24284, AA075002, AI264657, AI025716, AW408230, AI023409, W81429, AI807013, AA772235, AI860208, AI269880, AA644550, H03534, N44250, AA988507, AI051331, AI201765, N80176, AL043900, AA081004, AA923183, H58732, N76206, W03500, AI193593, AW384875, N66943, AA706242, N26033, N40857, AW236343, AW157602, AW131477, AI906913, AA886238, AW272410, AA808734, AA534807, N30627, AA608755, AA454946, AA831555, AA724567, AI743703, D63411, U21871, D13641, AF098274, AF098275, AC004074, AF098276, AC006001, and AF126961. HOFMH12 519 964722 1-464 15-478 X59697. HOFMH38 520 920365 1-401 15-415 AA070567, AA171448, AA307051, AA298011, AL120861, AI797040, AA314999, AA297768, AA171428, AA306518, AA297854, AA298067, AA297773, AA297845, AA297622, AA297767, AA174031, AA130315, AA298079, AA297689, AA297215, AA297921, AA297687, AA297842, Z31555, A45919, D43950, and AB022158. HOFMH95 521 973359 1-197 15-211 HOFMI01 522 609722 1-108 15-122 AW372827, AL134528, AL134518, U46346, AL119444, AL119391, AL042965, AL119363, AL119496, AL119319, U46341, AL119443, AL042970, AL134538, AL134532, AL119439, AL119484, AL042850, AL119418, AL119304, AL119320, and A81671. HOFMI62 523 796358 1-440 15-454 AJ388527, M21456, and X54067. HOFMI63 524 745133 1-211 15-225 HOFMJ44 525 719663 1-385 15-399 AA037037, AA046808, AI074059, AI025254, AI038824, AA046825, AI335087, W46671, AI141435, AI141175, W20117, AI081430, AA156232, R78487, F20461, W61182, AI086672, AI308846, AA157472, AA470526, W24222, AA302416, H40198, AA147488, AA804565, AI086624, AI074781, AI147805, AA888822, AI085738, AI088093, AI391491, AI146608, AI095699, AI312528, AI075648, AA927030, AI309731, AA863122, AA844067, AI831194, AI000826, AW263203, AA960909, AI571404, AI073644, AA927505, AA996038, AA888166, AA788786, AI085956, AA366542, AI079406, AA746698, W46844, AA485185, AI041513, AI880811, AA676445, AA974466, N95533, AA156054, AA082321, AI001112, W47172, N23131, AA225981, AA576992, AI741287, AI075640, AA975580, AI028417, AI023076, AI203524, AI079595, AI719742, AA046974, AA862562, AA382891, AI031831, AA082294, AA046881, N29263, AA071499, AA788814, AA137139, H81768, N20551, AA557947, AA854218, F29921, N28749, AI192144, AA071339, AA137068, AI085091, N49765, H98947, W61183, and AF070668. HOFMK22 526 675122 1-346 15-360 AW247757, AW239330, AA211149, AW249015, AW361739, AI557500, R18319, AF161479, AJ238379, AJ238742, AJ238741, and AJ238743. HOFMM27 527 973349 1-604 15-618 R80841. HOFMM72 528 464015 1-405 15-419 HOFMN30 529 514556 1-724 15-738 W46445, W46513, AA179186, AA128660, AA804464, AW196128, AA583251, AI953806, AI872319, AI284510, AI610404, AI926755, and AL133074. HOFMP31 530 698097 1-292 15-306 HOFMP79 531 775242 1-431 15-445 AA448573, AA252446, AA082102, W73318, AA339599, N24290, AA887226, R10417, AA037118, and U62940. HOFMQ04 532 823439 1-333 15-347 HOFMQ31 533 906933 1-437 15-451 HOFMQ65 534 789347 1-390 15-404 AW408436, AA403226, AW408309, AA323398, AA101050, and AL050369. HOFMS68 535 464075 1-338 15-352 HOFMS74 536 514568 1-580 15-594 AI276023, AI627898, AI539262, AI953242, AA947158, AA152216, T08709, H11221, and AC004126. HOFMS89 537 575820 1-502 15-516 HOFMT20 538 669738 1-288 15-302 HOFMT43 539 811542 1-504 15-518 X07382, and Z28396. HOFMT66 540 754251 1-328 15-342 AI432644, AI623302, AL134524, AI432654, AI432653, AW051103, AI432650, AI432677, AI431230, AI431307, AI431316, AW128900, AL045327, AI431328, AI431353, AI431312, AI432655, AI431310, AI431354, AI431323, AI431238, AI432666, AI431255, AI431347, W68610, AI432661, AL042898, AI431337, AI492519, AI432675, AI431246, AI431321, AI431315, AI431243, AI431351, AI431235, AI432651, AI432647, U46344, AL042508, AI432674, AI431330, AI791349, AI432649, AI431248, AI431241, AA362690, AI868154, AA362688, AW128884, AL042729, AI432672, AI431357, AI432665, AL042931, AI431254, AA362689, T29199, AI061457, AI432662, AI431345, AL047163, AL042842, AL042655, AI431346, AL042853, AI431231, AI432676, AI432673, AI432658, AL043166, AI431257, AL042533, AL047611, AI682915, AI431340, AL135012, AI872319, AI432657, AL042802, AI431247, AW128846, AI432664, AI432645, AL042787, AL042515, AL042832, AI431751, AL043295, AI927233, AI436446, AI866484, AW337580, AI431350, AI492510, AL043091, AI431318, AI431314, AI268898, AI886152, AI492520, AA130341, AL040207, AW128897, AI924051, AI866786, AW129223, AL042488, R42123, AI432643, AI932620, AI282247, AL042741, R43626, AI440238, AL043089, AI432656, AL046356, AL043321, AW194509, AL045328, R46015, AI431333, AL042420, AL047675, AI492509, AL043278, AA743065, AI654286, AL045891, Y17793, AL133074, I66487, I66498, AL133076, AF064854, AF019249, A49045, AR067731, AR067732, AL133053, AL133049, I07209, I09269, I66486, I09270, I09268, I07249, I09252, I09251, AR068508, AR068510, AR067734, AR068509, A63954, I09267, I91969, A49701, A29109, A32111, I66495, AR068550, A23373, AR068551, I66494, AR038307, AR038321, E01324, I08638, A94048, A94061, AR035224, A94046, A94054, I58322, I58323, AL122101, I66497, I66496, A27169, A27170, A39929, A83151, AL133068, AF118094, and AC005144. HOFMT72 541 563575 1-314 15-328 HOFMU33 542 702492 1-360 15-374 HOFMU63 543 744325 1-231 15-245 HOFMU75 544 713809 1-261 15-275 HOFMV84 545 859109 1-390 15-404 HOFNA04 546 615287 1-361 15-375 AJ223493, and U42725. HOFNA92 547 792734 1-329 15-343 HOFNC63 548 973354 1-342 15-356 HOFND14 549 658476 1-354 15-368 HOFND40 550 867984 1-329 15-343 HOFND50 551 727285 1-433 15-447 AI311825, AI673069, AL039753, AW151107, AW103107, and M85165. HOFND52 552 727173 1-395 15-409 AI492509, AI432658, AI431351, AI492520, AI431356, AI431346, AI431357, AI431342, AI432645, AI431236, AI431240, AI432662, AI431751, AI432676, AF064854, and AF048686. HOFND90 553 716670 1-430 15-444 HOFND94 554 717067 1-212 15-226 HOFNG01 555 859106 1-268 15-282 HOFNG06 556 935569 1-261 15-275 HOFNH33 557 715101 1-152 15-166 AW411124. HOFNI08 558 974435 1-412 15-426 W17180. HOFNI48 559 708727 1-364 15-378 AW245211. HOFNI82 560 717355 1-349 15-363 HOFNL18 561 666498 1-393 15-407 AA304945, AA355289, AA312114, AA495817, W72340, AA477457, AI669118, N79824, AI245484, AI372958, AW079905, N21556, AI093765, AW450650, AA099228, R56490, H15484, AW451773, AW236015, AL080166, and AL031432. HOFNL25 562 916963 1-502 15-516 HOFNL37 563 906250 1-382 15-396 AA853578, and AA853315. HOFNL40 564 711205 1-212 15-226 HOFNL92 565 770088 1-402 15-416 HOFNM85 566 869113 1-328 15-342 AW245750, AL035943, AW247594, N57316, N57425, T08768, Z43415, AW402184, AA313360, AA670088, W40348, W21269, T72713, AL035940, AW160492, AA313277, AW247213, AA361071, R94160, AL036958, W19964, R18379, T80869, AW405965, AW401713, AA378756, AA325636, N23610, AA340025, W17327, N55688, R19889, AA314671, AA853510, AW403145, AW401537, W22385, W46199, AA773406, W22826, AA345752, AA377322, AA346880, AA367230, AI034239, N87501, R12313, AI033895, AA295206, AW402954, AA204793, W45011, AI191804, AW366672, D31767, and AF085348. HOFNT59 567 615305 1-467 15-481 HOFNU72 568 705435 1-324 15-338 W20014, AW160778, AA400658, AA340701, AW402919, AW238859, AW161153, AW239281, AW408414, AA355461, AJ012504, AF107837, AF083245, AB009398, and AF086708. HOFNW10 569 916588 1-466 15-480 HOFNW79 570 973351 1-542 15-556 AJ388527, M21456, and X54067. HOFNY02 571 920218 1-569 15-583 HOFNY50 572 715312 1-481 15-495 AF047704. HOFNZ15 573 660317 1-394 15-408 HOFNZ16 574 859104 1-367 15-381 HOFNZ21 575 677372 1-444 15-458 AA172312, AW245781, AW245685, AI922686, AI752241, AL045207, AW162793, AW239365, AW250530, AI815398, AA306149, AA223817, AA314658, W44751, AW083164, AI123512, AF100752, AC004472, M30143, and U11760. HOFNZ58 576 683473 1-363 15-377 HOFNZ94 577 794308 1-334 15-348 Z86062. HOFOA17 578 935553 1-357 15-371 HOFOB88 579 751692 1-489 15-503 AI290790, AW192390, AW291738, AA836267, AA885601, AA911254, AA908258, AI123091, AA262071, AI279611, AA987244, AA335969, AB007946, AB007923, and AF139185. HOFOB91 580 827631 1-220 15-234 HOFOE94 581 924473 1-532 15-546 HOFOF57 582 666909 1-406 15-420 N40054, N27721, AI131355, AA436038, AA292974, AI557218, AW274996, AA631848, AI539429, AI146318, AI804348, AA233902, AI525325, W25483, T47061, AA211343, C17967, AA299376, AW005799, AI090743, T78524, AI363335, AI082444, AI096906, AA327206, AI422717, AI347590, H44711, AI087101, AA743800, AA557194, AI022687, AA234130, AA732876, AW136326, AA339885, AA211344, AI547066, AI333899, AA810604, AI359155, H43647, AA810608, AA771974, AI142815, AI924652, AI219430, W19321, and AD000671. HOFOF84 583 739399 1-627 15-641 HOGAF39 584 947431 1-346 15-360 AI885126, AW166364, AA490377, AA808700, AA811849, AA524458, AA714038, AA293472, AA890365, AI027804, AI479104, and AF176525. HOGAU90 585 954011 1-388 15-402 HOGAV36 586 926098 1-825 15-839 AI346561, AI380209, and AW135850. HOGBF78 587 575929 1-429 15-443 AA080880. HOGCQ05 588 950216 1-478 15-492 W60879, AI017482, AI928127, AA635802, AI474401, H20562, H18660, AW104847, AA196061, AI337811, R49248, AI479145, R42810, W55877, AA708337, R08049, AA746497, AI039052, AA767341, AA485383, AA446217, AA618521, AA993040, AI097619, AA424341, W93047, AA721661, AA993427, AA810160, AI027510, AW006638, N95297, AI215635, AI004757, AA401727, AI537770, AA435959, AI394624, AI913889, AI559985, AI369769, N90601, AW003287, AI870166, AI570651, AI138811, AI763307, AA290608, AA417963, AW006982, AA281628, AA687619, Z39492, AW241279, AI420717, F02765, AA719464, AA678086, W92459, F03750, AA011105, AI022646, F10173, D51379, AA781896, AI168342, AI081609, AI684382, AA719707, AI202625, H02623, W55878, T33859, N91472, T98912, R83010, AI568204, H46724, H26709, AI383107, AL079597, AA082037, AI368048, AA610613, T16672, AW197260, AA041211, T32957, AI089022, AA678434, AA493501, AI365549, AI912693, AA418140, AI199525, AA446216, AI266356, AW444914, AA055740, AA702510, R59227, AA505711, AW394008, AA251476, AI825733, AW385277, AI690768, AA280842, AW023656, AI608689, D19949, AI907549, AA397950, AC004447, and AB002363. HOGCR32 589 575931 1-195 15-209 D86958. HOGCT45 590 717068 1-549 15-563 AI929611, and AW161854. HOGCX95 591 890607 1-767 15-781 AI073430, AA406136, AW269419, AI004814, AA707533, and AA383178. HOGEE76 592 968956 1-871 15-885 AI056641, AW117435, N72573, AA375847, AA375611, AA380835, AA677344, AI271175, AI307084, AI337700, AI305507, AI340671, AI312153, AI224651, AI275349, AI310667, AI349142, AW269088, AI271176, AI224760, AI311163, AI311628, AI345622, AW074879, AI251594, AI792507, AI254775, AI252013, AI306337, AI252014, AI054093, AI224693, AI305393, AI224324, AI271313, AI792707, AI820860, AI251151, AI287949, AI287943, AI249867, AI254561, AI305649, AI252915, AI345009, AW073435, AI349992, AI271146, AI250142, AI252424, AI305931, AI306018, AI305395, AI336707, AI336820, AI337695, AI337711, and AI337773. HOGEU49 593 961587 1-272 15-286 HOOJQ59 594 965013 1-699 15-713 AA551303, H77748, AI341538, AA281640, AA838724, AA523324, AI023519, AA887803, AI681516, AI371385, AA962758, AA994841, AI868341, AA670061, AA778604, AA865306, AI360419, AI041265, AI050715, AI193427, AI569655, AA554009, AA315106, AI357495, AA044296, AA535136, AI015647, AA131586, AI735282, AA126719, AA976084, AI523059, AA659914, AA879213, AA748069, F33750, AI002087, H04044, R38305, AW131546, AW391885, AI354856, AA458689, AI479801, F27238, AI311108, AA720819, AA044123, AA334077, and AC006509. HOVAF17 595 576627 1-344 15-358 HOVAF71 596 757294 1-370 15-384 HOVAG49 597 927320 1-479 15-493 AA143074, AA987383, W60511, AA680304, AA827641, AA308290, AA401334, F25999, AA313726, F22587, AI358423, AA315506, AI141189, W58769, AA575866, AA515848, F19218, F19304, AA156103, F37437, F33656, N98867, F25212, AA740468, AA157759, AA728989, P24956, AA608827, F36060, AA737291, AA194358, AA932208, AI143027, F24362, F31772, F27422, F32057, T57362, AA192185, F24856, AA995725, AA741404, AA314904, P34156, AA889507, AW022412, N55638, F20992, AA526390, W90626, AA007592, F21312, AA954254, AI749361, AA148433, AA579682, F29723, T57445, AI291661, AI282169, F29662, AA491525, AA747585, P22463, P29957, F31884, AI536594, AA664969, F31246, F33617, AA730678, AA385186, F35367, F20491, F29466, F37060, F24202, AA705812, AA492193, AA382505, W88582, AA314719, F34612, W04663, AA157650, F30675, F23580, F27384, F31800, F27612, AI933136, AA974467, F35170, AI826775, AA528421, F29578, F23463, AA767198, F34150, F24124, AA384045, AA492088, F27860, N56464, F31547, F34856, AA594575, AI276978, F33998, AA316521, AI133697, P28088, F29835, F37748, AI384039, AI810403, W81175, AI867973, T74339, AI701341, AA639064, AA976781, AW241684, AA247353, AA007389, F23553, N89217, F27386, T23491, Z40911, T16443, W90249, and AD017710. HOVAI41 598 670963 1-93 15-107 HOVAM50 599 723671 1-350 15-364 HOVAO76 600 770066 1-860 15-874 H13051, R31396, Z36861, AC007057, and AL049872. HOVBQ10 601 964671 1-808 15-822 AW449247, AI089920, AW452240, AI378795, AA431282, AI188684, AI800797, AA236983, AI078809, AI147017, W07506, AI217995, AA976845, AI093869, AA405781, AI150770, AA405716, AI014997, AA235925, AA578443, AA257058, AA773503, and AL078474. HOVBY34 602 706816 1-404 15-418 AA846482, AA728911, AL043212, AI653783, T47138, AA832016, AA831801, AI185394, F31951, T52772, AW079737, AW271085, AA714073, AA552724, AA810154, AA018923, AA012829, AA633565, AI061619, AI306717, AW419389, H91047, AI800343, AI342786, AI300413, AA356376, AA846923, AA496309, AI915081, AA745628, AA298569, H43183, AI417586, AA640252, AW019964, H62550, AI873627, T40629, AA053463, AI300818, AI310992, AW302670, AI270120, AA230146, AA805848, AI671077, AW084173, AA568856, AL134332, AA626632, AI583291, AA366601, T62078, AI904944, AI133418, AA862029, AA513884, AI889579, AW002330, AI479148, AA568314, AA768179, AI278847, AI627868, AA297789, AI434037, AI251809, R84528, AW272640, AI130709, M78021, AI536858, AI537995, AW073598, AW089016, AI287766, AA434078, AA745543, AL039761, AI281818, F31811, AI445373, AA742775, AI619994, AA811954, N69399, AI302277, AA167179, AA678616, AW341955, AI814682, AW243945, AI291439, AA715605, AL134418, AA728874, H73306, AL037632, AL041375, H84412, H43771, AW078821, AI431513, R70883, AA904211, AA173166, AI678476, AA856866, AA469282, R87912, AW169118, AA633039, AW390284, AW117723, AA569597, AI347665, H67172, AI865776, AA244181, AA714921, AI955029, AW190277, R87883, AI472736, AI591134, H42893, N91138, AW079667, AW089950, AA599532, R70884, AW272815, AA644223, AW148775, N73060, AA371410, AA420729, AW440568, AI343669, AI064781, AI309121, AA581498, AI583466, AW274191, AI306232, AI251576, AI733856, AI612810, AI817108, AA678932, AI811647, AW002831, AW081610, AA483606, AA019003, AI816058, AA515351, AI628859, AA229988, AA363003, H86221, T74524, AA937809, AA515924, H29914, AL039309, AA630845, AI889995, AI859744, AW117704, AA302661, AI370170, AC006487, AP000555, AC006312, U18271, AC005231, AC005037, U73330, AC002467, AC004491, AC005288, AC004843, AL008629, AC007686, AC007298, AC004878, AL031120, AC007269, AF027390, AC007055, AF039906, AP000300, AP000113, AP000045, AC005740, AC005529, AC003101, AC004526, AF112482, Z79996, AC003086, AL096761, AC002544, AJ246003, AP000884, AC009247, AC004651, AC004760, AF176815, AC005005, AC006111, AL121658, AC005003, AC008078, AC004991, AL024508, AC005553, AB023050, AP000212, AP000134, AC005089, AC006061, AC004601, AC005684, AC006101, AP000350, AL121754, AC008064, AL096775, AC005532, AC004883, AL096791, AC007514, Z98304, AL031575, U95739, Z83845, AL031005, AL031433, AC002117, U51244, AL031585, AL049575, AL049550, AC008082, AC006449, AC003051, AC004084, AL049610, AC007225, U91319, U91320, AC008545, AC002549, AL031584, AC007344, AL022318, AC008040, AC005940, AF115566, AL109758, U95742, AL117351, AL034423, AF111169, AC006392, AC002543, Z81365, AC005081, AC007277, AC004692, AL049776, AC005015, M87889, AC000090, AP000252, AC005031, AP000030, U80017, AL022396, AC004655, AC006360, AC004025, AC007666, AC004686, U02047, AP000122, AP000054, AL121825, AP000289, AC005480, AP000042, AP000110, AL008730, AL031289, AC005011, AC007182, AL121652, Z98036, AB003151, Z95114, AC004687, AL096818, Z48051, AC002100, AP000067, AC006162, L47234, Z83733, AL035072, AL049749, AC003983, AC000159, AF196970, AL031429, AL031664, AP000355, AL023775, AL031737, AF001552, AC004896, AC005519, U94776, Z75407, AL109627, AL035422, AC007358, AC003108, AC005899, AF196779, AC000134, AL031431, AC006238, AC005602, AL049872, AC005409, Z85986, AL049764, AD000812, AC003072, AL049733, AL023575, AC002126, AL035681, Z93930, AC004540, AC006501, AC000111, AC006013, AL031228, AC004895, AC004776, AC005924, AL080250, AC004000, L78810, AC004231, AL031311, AL117337, AC007736, AC005722, AC005274, AF205588, AP000116, AP000049, AC005247, AL021878, Z99716, AC003690, AL022574, AC004073, AL008635, AC004535, AF196969, AL031295, AF207550, AL078603, AL033381, Z83820, AC007878, AC009509, AC005036, AF130343, AC005207, AP000311, AL035420, AC006388, AP000313, AL078471, AP000194, AP000050, AP000117, AC006141, AB001913, U73628, AC007216, AL031722, U07562, AC005593, AL022320, AC007242, AC004822, AC004812, AC002432, Z98884, AC006536, AB016897, AL031767, AL109827, AC002477, AC006473, AC002400, Z94801, I34294, AP000322, AC005625, AC006163, AC003959, AP000152, and AP000053. HOVBZ26 603 888442 1-203 15-217 HOVCA52 604 727170 1-409 15-423 HOVCD39 605 705406 1-360 15-374 AA535937, AC002314, AC005206, AC005667, AL049832, AC005668, AF111169, AL022316, AC007376, AF001549, AC006160, AC005412, AC007955, U78027, AC007041, AL035422, AC006285, AC005261, AC007227, AF134726, AL031311, X14448, AC005786, AC006257, and AL049830. HOVCI76 606 858845 1-346 15-360 AL049694. HOVCI77 607 713792 1-263 15-277 HOVCJ24 608 858844 1-305 15-319 HOVCM22 609 674177 1-475 15-489 AF150146. HOVCO11 610 970814 1-1454 15-1468 AI923848, AI680189, AI401617, AI373875, AA455317, AA701656, AI472034, AI573004, AL120931, AA398429, AI051123, AI624093, AI248617, H99041, AI355692, AA687849, AI355703, AI359209, AA757226, AW131426, N33217, N91144, AI342620, N27564, AI298478, AI589126, AW193312, AI923367, AI890992, AI435647, AA788753, AA601557, AI682609, AI583218, AA678000, AW168929, AA614659, AI298694, AA036731, N66889, H97544, AA745905, D62527, H18598, N89744, AI245176, AA403052, AA150090, AI248821, AI287545, N22090, AI263846, AI245198, AA894619, AI185100, AI272966, R69930, AI075972, AI242237, AI435894, AI348194, AA479068, H46858, AI511692, N47754, AI784586, AW058621, AW081918, AW168028, AI346563, AI566456, AI186661, AI433476, AI770052, AI963008, AI187073, R69882, AA812522, AI888697, F36516, AI890986, AA514269, F11075, C02214, AW002830, AA381400, AA381382, AI143203, AI350680, AI375753, AA968981, AI432046, AI080704, AW169284, AI866206, AA150159, AA381630, AI566594, AA381701, AA381636, R76807, R20526, AA844237, AA381643, R27302, AA381945, AA904561, AI280761, R66707, AI382360, H04179, D61736, AI697429, AW378387, R67586, AA805532, AA381644, AI932870, N93493, AA381602, H18624, AA381460, AA381275, AA476343, AA654417, AW104101, N90151, AI805033, AA347509, R32649, R33334, F31071, AW051256, N56395, AA455704, AA744342, AA291227, AA089961, AA761970, N40385, W17019, R07700, N41931, AW021551, R66241, AA284149, AA381605, R52479, T75133, R75976, AW152083, AA167390, W81443, AA804381, AA366783, AW057830, AA482823, AF139791, AA427526, H27061, AA909840, AI802150, AW378359, AA808476, AI679723, AA765452, H39601, AA889282, H18597, AI679152, W04813, AI216644, AW378412, AA036938, T20149, AI915452, AA130568, R33333, AI570298, N34507, AI280767, AA632567, AA216333, and AC004520. HOVCO58 611 736065 1-408 15-422 HOVCQ47 612 496190 1-628 15-642 AA176289, AI341253, AI476272, AI631533, AA609460, AA503370, AI797388, AA421578, AA421007, and AA310749. HOVDY04 613 926219 1-532 15-546 AA725889, AI937507, AI090742, AI190613,AI363396, AA485978, AW137065, AI061260, AA029073, AW449608, AA488604, AA928760, AI560967, AA908207, AI499789, AI499666, AI638627, AI638193, AA670299, AI699081, AI695989, AI538115, AA700477, AA969203, AW207595, AW007189, AA693349, AA029072, AW453024, AL119457, AL119324, AL119418, AW392670, Z99396, AL119443, AL042544, AL119399, AW372827, AW384394, AL119319, AW363220, AL119497, AL134902, U46351, AL119484, AL119391, AL119522, AL119363, AL119355, AL119483, U46350, U46341, AL119341, AL119335, AL119396, U46349, AL119496, U46347, AL042965, AL037205, AL119464, AL119444, AL119401, AL119439, AL134525, AL134536, U46346, AL134538, AL134531, AL042614, AL042984, AL043019, AL042975, U46345, AL043029, AL042542, AL042551, AI142132, AL042450, AL043003, AR060234, AR066494, A81671, AB026436, AR054110, and AR069079. HOVEE58 614 968699 1-251 15-265 AA370036. HOVEK70 615 909138 1-804 15-818 AI126171, AI807074, AW172978, AI802445, AI811298, AI624106, AI635206, W96514, AI190433, AI810701, AI271523, H43143, AI911113, AI803788, AI566934, AI187824, AA644026, AL043767, AI869010, AI015017, R55050, AA043579, AL045986, W96481, and AA568260. HOVEV36 616 959234 1-531 15-545 HOVJA10 617 961467 1-430 15-444 HPCAB21 618 573829 1-141 15-155 HPCAB31 619 698320 1-456 15-470 R73849, HPCAE18 620 574952 1-343 15-357 AI910277, AW339592, AI492757, AA767543, AA568133, AB014555, and AB013384. HPCAH18 621 573395 1-337 15-351 AL096817. HPCAH88 622 953808 1-624 15-638 R61213, AA021151, AL118746, and AA336609. HPCAI21 623 655535 1-293 15-307 HPCAI68 624 655536 1-346 15-360 HPCAK16 625 662121 1-622 15-636 HPCAK57 626 734931 1-407 15-421 AL031665. HPCAL60 627 655723 1-317 15-331 AI287445. HPCAL86 628 924709 1-308 15-322 HPCAM22 629 655607 1-415 15-429 AC002381. HPCAN59 630 655742 1-282 15-296 HPCAO04 631 655732 1-316 15-330 AA622352, and Z18305. HPCPF05 632 927168 1-525 15-539 AW294804, AI193110, AI300529, AI336265, AI160012, AA029612, AI832813, AA722195, AA121508, AI860181, AI141465, AI570532, AI857944, R32118, AA099271, AI096365, AI342221, AI808491, AI862033, AI559677, AW023430, AI361255, AI371048, AA865682, AA748042, AI336001, AW022229, AI359397, AA026111, AA115634, AI431331, AI911906, AI680468, W93126, AI954960, AW088396, AI190286, AI346804, AI130942, AI091483, AW189276, AA688307, AI189025, AI767694, AI799469, AW380356, AA807668, AI354954, AW380375, AA043929, AW022523, W02100, H92712, AI301595, AI202850, AW380384, H99705, AI982790, AW237470, R65725, AA098892, AA470877, R24056, AA564293, AI651164, AW271629, AW380377, AA853830, T17200, AA468597, AI651187, R79227, AI686761, AI805208, AA873325, AI077608, R32496, N80064, AI758913, C00620, AI214710, AI783865, AW380370, AA127733, N91757, R65726, AI689514, AI687869, W07026, W00844, AP000315, AP000165, and AP000118. HPCPO07 633 951826 1-289 15-303 HPCQY57 634 927135 1-357 15-371 AW008782, AW050625, AI631996, AI738644, AW050639, AI826984, AI865021, AI823343, AI983601, AI522217, AW195206, AI748866, AI439278, and AF157630. HPDOT03 635 922481 1-370 15-384 AI929455, AI816461, AI650907, AW138789, AA577366, AI633916, AA974004, and W57636. HPDOY06 636 929318 1-243 15-257 HPDPJ69 637 966158 1-592 15-606 AW168960, AA833900, AA384359, AI761053, AW169324, AL080317, AL031073, AF179874, AC007068, Z98750, AC007319, AC006047, D84394, and AP000509. HPDPK12 638 969340 1-304 15-318 AA424185, R07403, AI074550, AI074543, AA829693, AA603234, M77858, H56912, AA193445, AA640755, AA296002, N72812, AI803827, N63746, T85040, AA346355, AA865344, W37250, AW245054, AA278641, AI803791, AA669238, AI708384, W42997, AW075979, N71033, T63772, AA189154, R43401, AA837708, C14614, AW073510, R65651, AA504561, AW438765, AI473581, AA740297, AI224583, AA282951, AI049845, AI027056, AI689695, AI192839, AW151713, AI554399, N22797, AA657505, AA129133, AA088727, AA830594, AA569474, AA586661, T92947, AI821239, AW150476, AI350189, AI611331, AI421257, AI362442, H65404, AW342029, AW166879, AI340280, AI433131, AW440315, AI761120, AI342863, AA974503, AI611736, AA748913, AA483211, AW082470, AA299220, C05714, AA526630, H73230, AI702522, AI791336, AA532594, Z83822, AC007676, AL078593, AL117338, AL110161, AC004070, AC002412, AC005911, AL109853, AL049759, AC006115, AC005944, AC004750, AC004647, AL049776, AC005060, AD000833, AL096766, AC004149, AL078644, AC002563, AC005519, AC009247, AC007461, AL133445, Z93242, Z97056, AC005682, AC004771, Z82180, AF003626, AC008044, AL035667, AL009179, U52112, AC006265, AL135744, AP000959, AL022313, AP000011, AL132712, AC009178, AC007790, AC006597, AC007546, U95742, AC007216, AC000088, AC000082, AC003037, AC006511, AC006197, AL035400, AL079295, AR060469, AC006140, AB023052, AC005933, Z82976, AC004559, AC005943, Z84721, AL050306, AL023575, AC006974, AP000513, AL050341, AC005004, AC005281, AC004796, AL034408, AC004686, AC006571, AC004126, AC007425, AL031848, AF064862, AC002553, Z83844, AP000555, AC005618, AL110505, AC005037, AC004893, AC005150, AF141309, AC005544, AC004655, AC006001, AC005089, 877127, AB023049, AC004188, AL021807, AC006071, AP000516, AL035659, AC003663, AC007666, AF159056, AC007214, AC006033, AC003080, AF111169, AC000052, AC004019, AJ011930, AC007051, AF001552, AC003982, AC007919, AC003953, AC007685, AC005666, M87896, AL022324, U63630, AP000302, AC000073, AC006162, M89651, AC004073, AC005183, AL023578, Z98752, AP000114, AP000046, AP000141, AC000085, AL031133, AC006539, AC004150, AP001054, AC002477, AC006236, AC004659, AF001548, AC006036, AL133353, AC004832, AP000088, AC006116, AC004386, AL031283, AC006249, AC005291, AC003106, AB003151, AP000688, AC005386, AC005841, AL049576, AP000509, AC006261, AC000075, AC005885, AL034555, AL031670, AC004020, AF165926, AC006199, AL021917, AC007344, AC003101, AC004526, AC002544, AL109963, AF196970, AC005082, AL096791, D86995, AC002316, AC007283, AC007207, AC005664, AC003108, AC005369, AC002454, AC004820, L44140, U78027, Z97206, AL035422, AC003071, AC007556, AC006461, AC007537, AL031255, AL121653, AC004017, and AC002039. HPDPQ40 639 922464 1-615 15-629 AI911379, AI382036, AI523065, AI567528, AA628532, AI359162, AI356788, AA483453, AA483438, AI811858, and T07668. HPDQ005 640 929274 1-1104 15-1118 AI023890, AI744865, AI961389, AA694270, and AA778846. HPDRB01 641 914437 1-540 15-554 AA508138, AI950798, AA013140, AA013366, and AL035594. HPDRD28 642 957791 1-498 15-512 AI803130. HPDRG92 643 967704 1-347 15-361 T96738, R90778, H47758, R94024, AA323896, N51812, and AB033116. HPDRO20 644 957678 1-208 15-222 AI925316, C20550, and AW383499. HPDVB07 645 951634 1-661 15-675 AL008628. HPDVE05 646 928647 1-828 15-842 AA621983, AI738475, AI380189, AI380858, AI127232, AA622706, AW204003, AA621975, AI587036, AA665743, AI692234, AI249654, AI246971, AI246864, AW268783, AI692219, AI002242, AW137282, AW295910, AI308015, AI318288, AW301462, AI246934, AW268311, AI345591, AI246816, AI318117, AW301382, AI311495, AI610947, AI252418, AW086332, AI251546, AI792842, AI792856, AI345144, AW072879, AI313327, AJ223366, AI249650, and AI318575. HPDVF03 647 922193 1-834 15-848 AI183572, W03052, AI656704, AI916980, AA642326, AA337377, AA337144, and AA249832. HPDVK12 648 968977 1-560 15-574 AI148863, AJ765291, N70646, AI914033, AI458020, AA551814, AI311395, and AW175659. HPDVM06 649 933443 1-673 15-687 AI377852, AI283476, AA954783, AI914476, AI918738, AA371003, AW372827, AL119363, AI142137, AL119444, AL043011, AL119319, AL119304, AL134528, AL134518, AL119483, AL119522, AL134538, AL119439, AL119484, AL119391, AL119496, AL042970, AL119396, U46346, AL043033, and AL031777. HPDVY17 650 955902 1-432 15-446 HPEAF19 651 867892 1-291 15-305 HPEBA06 652 960802 1-242 15-256 AA299493, AI580853, AA303099, AI287555, AA299492, AI279700, AA559290, N71724, AF177861, AW338869, AA493503, AA367546, AL031777, AC006130, U73024, AC009509, Y10196, U63721, AC006333, AC004047, AJ012197, AL139054, AL050333, AC006544, AC004527, and D87008. HPEEA51 653 723298 1-423 15-437 N69328. HPEBD31 654 655760 1-538 15-552 AA196263. HPEBE44 655 716911 1-456 15-470 T72867, AA610577, and AC007695. HPEKG18 656 914115 1-84 15-98 AF111167. HPEKJ42 657 922391 1-214 15-228 HPEKU27 658 921663 1-428 15-442 HPEKX12 659 969251 1-355 15-369 AA737020, AW134485, AI874258, AI217712, AA935591, and AW389859. HPFAA06 660 960801 1-429 15-443 AC004111. HPFCA36 661 524720 1-275 15-289 AI798807, AC007065, AF073930, and AF064804. HPFCA71 662 655596 1-351 15-365 HPFCF09 663 536666 1-343 15-357 AA617957, AI168322, AC005886, AC006071, AC006561, AL096791, AC004223, AC005670, AC002094, AC005156, AC002300, AC004815, AC007308, AP000212, AP000134, AP000030, AC006255, AC004685, AL132987, Z93017, AC002425, AL096701, L77570, AL021453, AC004890, AL049766, AP000555, Z83840, AC005089, AL049650, AC005756, AC008116, Z98941, AL034549, AL109952, Z98036, AL023575, AC002470, AL133445, AC007077, AL121658, AC005187, AC007279, AL080243, AC007546, AC006962, Z95113, AC005332, AC008372, AL031587, and AL035249. HPFCF24 664 655744 1-398 15-412 HPFCF40 665 968600 1-339 15-353 HPFCF83 666 781490 1-329 15-343 AI749823, R99144, AA302658, AW161459, F24175, AI243793, AW161879, AI191343, AA130647, AI679221, AI003797, AA936548, W45457, H24953, AC005057, U62293, U63721, AC005829, AC005102, Z97630, AC005229, AL049830, AF111168, AL035658, AL132712, Z97054, AP000116, AC006241, AC000159, AC002300, AC005747, AB023051, AC009946, AC005323, AC006121, AL049692, AC003030, AC007536, AF047825, AL049757, AC004253, AC004520, AL109952, AC004030, AL023882, AP000512, U91321, AL022313, AF196779, AC020663, M55987, AC004893, Z75407, AF102137, AC003665, AC004033, AC002477, AF207550, AC012331, AC007666, AF064861, AL049548, Z84480, AC002107, AL030996, AL024507, AC006057, AC004841, AL078644, AC005480, AC002310, Z83838, AL022326, AC005332, AF165926, AC006061, AC005529, U07561, AC008044, Z95114, X14448, AC004522, AL050307, U63834, AC005846, AL035086, AL022322, AC007226, AP000065, AC005755, AC005914, AC002115, AC005015, AC002073, AC005971, AL031311, AC002350, AC004876, AL022163, Z93930, AC005920, AL031295, AC005527, AC016831, AC005105, AC005081, AC004890, AC002351, AL049780, AC004560, AL020997, AC006449, AC006251, AC008012, AL034379, AC007055, AF001549, AC004475, AL035405, AC003682, AC006512, U80017, AC006480, AL035450, AC006285, AD000092, AL023803, AL080243, AD000671, AC005409, AC005274, AF001550, AC004129, AC002492, Z98950, AC005632, AC007263, U91326, AL034555, AC005839, AL031289, Z82203, AC002365, U91323, AL031659, AF045555, Z84469, AL022336, AF148808, AC005722, AL049869, AC006948, AC003041, AL022316, AC005184, AC007304, AC005874, AF134471, AP000502, AP000010, Z86090, AC005182, AC005479, AL031685, AL031393, U78027, AL021368, AC007207, AC004815, AC005363, AC002470, Z93017, AL021546, AP000553, Z99716, M63543, AC007917, Z95331, AL121754, AC002395, AC004884, AC005625, AC004859, L78810, AC007021, L44140, AC005399, AL021878, AL034553, AP000691, AL031230, AC006453, AC002316, AC004024, AC006211, AP000547, AC006515, AL049569, AC002106, and AL031591. HPFCH15 667 655768 1-344 15-358 HPFCH89 668 655538 1-226 15-240 HPFCM41 669 655736 1-356 15-370 HPFCM87 670 925495 1-305 15-319 HPFCN08 671 960365 1-363 15-377 AA651633. HPFCO02 672 867871 1-263 15-277 W85782, AA703530, T99014, and C14044. HPFCO67 673 867880 1-293 15-307 HPFCQ88 674 655749 1-387 15-401 AI821958, AW150896, and AW205057. HPFCR21 675 655621 1-452 15-466 HPFCR82 676 655533 1-389 15-403 HPFCT09 677 655563 1-311 15-325 HPFCT53 678 974257 1-634 15-648 AI525556, AI546855, Z28355, AI526194, AI546999, AI525328, AI556967, AI525316, AI541374, Z30131, AA585356, C16300, AI525306, AI541508, AA585101, AI541523, AA585439, AI546945, AI546899, AI557799, AI541510, AI525431, AI557731, AI557082, AI541013, AI546875, AI557807, AI546828, AI541534, AI540967, AI526180, AI541307, AL134524, D61254, AI547039, AI541535, AI526140, AI541365, AI526184, AI536138, AI557262, T11028, AI540920, AI535660, AI557238, R29445, AI525653, D57491, AI525321, AI557796, AA585453, AI557787, AI547071, AI535813, AI526144, AL041197, AL040155, AL041346, AA585476, AL041096, AL047012, AL041358, AL041277, AL041163, AL041098, AL040621, AL043538, AL041324, AL040464, AL044162, AL041086, AL043496, AL041296, AL041233, AI541415, AI541017, AI5415 14, AL045725, AL041140, T23985, AL040193, AI541205, AL043612, R28735, AL040149, AL039915, AI535639, C16305, AA585440, AL040463, AI546971, AI525320, AI557084, AL047219, AL041227, AL047057, AL047170, AL040119, AL047036, C15189, AL041292, AL041051, AL047183, AL040322, AL041131, AL046330, AL041133, AL041238, AL041142, AL045817, AL040529, AL040625, AL040510, AL043467, AL044186, AL040553, AL044037, AL040091, AL040128, AL040168, AL040255, AL040285, AL040342, AL040332, AL040617, AL045684, AL040745, AL040370, AL043677, AL046442, AL041 159, AL041246, AL040839, AL041752, AL043775, AL044165, AL043492, AL04 1602, AL043444, AL045920, AL038838, AL044074, AL04 1635, AL045990, AL040458, AL044199, AL044187, AL040253, AL040263, AL040090, AL040294, AL040329, AL040082, AL044272, AL041 186, AL040444, AL040148, AL041730, AL041523, AL043627, AL043537, AL046392, AL041374, AL040052, AL041347, AL043845, AL044529, AL039338, AL042135, AL044064, AL039316, AL043923, AL038983, AL043814, AL043848, AI526196, AL040576, AL041459, R29177, AL043570, AL041577, AL044258, AL044201, AL046850, AL038532, AL040768, AL037727, AL045753, AL038761, AL040075, AL046994, AI526187, AL040414, AL040571, AL044274, AL046914, AL079878, AL049018, AI142134, AI557802, AL045857, AL041278, AL039744, R29218, T41289, AL038822, D55233, AL080031, AL046327, AL041168, AL045671, AL049069, AI557808, AL040472, AL041955, I18597, AL040238, AA585155, AI541075, AI546891, AJ239433, AL045989, AL039360, AI546810, AI541317, AL042096, AL079852, AL046147, AI540916, R45895, AI557727, AI541390, AI526073, AI525856, AL044125, AA174170, AI541345, D61185, AI557734, AI547006, AI557740, AL039643, AA585434, AI557279, Z32822, R28967, D57186, AI541517, AI525339, AR038762, X81969, I13349, AR017907, A25909, A91965, AR062871, I66485, AR038855, I66487, A85395, A85476, I18895, AR008429, AJ244004, AR037157, AJ244005, AC005913, AR062872, AR062873, AJ244003, AF082186, U94592, A20702, A20700, A43189, A43188, AJ244007, I63120, A98767, A93963, A93964, A98420, A98423, A98432, A98436, A98417, A98427, I44681, X83865, A84772, D78345, A84776, A84773, A84775, A84774, Y16359, AR054109, AR067731, I15717, I15718, Y09813, AR067732, A86792, A58522, A91750, I08396, M28262, I08395, A60212, A60209, A60210, A60211, E03627, AI8053, I48927, I06859, I84553, I84554, I00682, A02712, I49890, A77094, A77095, A81878, A35536, A35537, A11623, A11624, E00609, A95051, A02135, A04663, A02136, A04664, AI8050, A23334, A75888, I70384, A64973, A60111, A23633, E13740, AR007512, AI1178, E01007, AI0361, Z32836, I62368, AI1245, A93016, AR043601, I03331, A02710, E12615, AR035193, AF149828, E14304, A07700, AI3392, AI3393, AR031488, I13521, I52048, A27396, D50010, AR027100, I44531, I28266, A90655, I21869, A92133, I44516, A70040, AR031566, E16678, A82653, E16636, A95117, AR038066, A24783, A24782, A58524, I01995, A58523, I25027, I08051, I26929, I44515, I26928, I26930, I26927, I60241, I60242, A20699, E00696, E00697, E03813, I66482, AR009151, I66483, I66484, I66498, I66497, I66496, AR027099, I66486, AR051652, AR051651, AF134471, A70872, AJ230935, I05558, AJ230902, A70869, AJ230972, I08389, I34294, AC012099, D13509, AC007200, AC006057, AC002045, D13316, A22738, AC002037, AC007707, AP000310, AP000116, AJ131757, AP000299, AP000045, AP000113, AL049570, AC005944, AP000156, AL096803, AP000014, AL035461, AC003009, AL031664, AC005740, AC007860, AC004830, AC005874, AB025273, AC005559, AC008039, Z84468, AL022156, AC000394, AC004130, AP000252, AL109963, AP000030, AP000212, AP000134, AC005630, X55503, U07807, AC004653, AL109956, AC000003, Z98272, AC005202, AC004079, AC005476, Z95889, AL080250, AC005284, AC005777, AL023694, AL035457, AC009263, AJ006216, AC008545, AC005480, AC004148, AC006966, AJ003081, AL035462, AC006208, AF207550, AC007993, AC005509, AL050318, AC006011, AC007687, AC006312, X99832, U72788, AL009183, AC008967, AL049633, U80017, AC003667, Z97055, AC005383, AL049697, and AC006480. HPFCT62 679 655432 1-310 15-324 AA487150, AA486829, AA347969, AA622801, AI078409, AA602906, AA084609, AL078621, Z96201, AC005484, AF064861, AC004862, AL021393, AP000501, Z97056, AC005244, AL049569, AC005225, AC005318, AC007371, AC002477, AL035443, AF111168, AC004821, AC005104, AL133448, AC006388, AC005839, AL035249, AL022336, AF196969, AC004448, AC009247, AC005562, AC005058, AL079305, Z98051, AL132985, AC005261, AC005089, AC002350, AP000116, AC003102, AC005071, AL050318, AC004525, AC005332, AC006449, AF001550, AC005409, AC004967, AC006312, AC005924, AP001052, AC005519, AC005920, AC010205, Z83838, AC004685, AC005231, AC004814, AC004878, AC005081, AL049776, AC004983, AF130248, AC006946, AL034429, Z86090, AL031984, AC004851, AL109627, AC003663, AL031286, AL049636, AB023049, AL008720, AC004584, AL109798, AC005880, AC002527, AP000553, AL033527, AC004253, AL034420, AC006441, AC000353, AC002303, AC004678, AL008726, AP000692, AL133246, AC004905, AC005015, AC005037, AC002551, AC005088, AL049780, AC002094, AL031587, AL031282, AC004531, AC004655, AL035691, AL024498, AL035458, AC006965, Z95152, AL022238, AP000689, AC004811, AL049539, AC005479, AF001549, and AC002400. HPFCV19 680 655706 1-302 15-316 AI279012. HPFCV71 681 525554 1-536 15-550 R31337, AW028647, and AF178081, HPFCX18 682 655588 1-325 15-339 HPFDD06 683 960700 1-291 15-305 AI557495, and AI557116. HPFDE38 684 655704 1-343 15-357 AI417952. HPFDB61 685 974249 1-681 15-695 HPFDF79 686 973732 1-576 15-590 HPFDG58 687 655610 1-310 15-324 HPFDI23 688 655549 1-355 15-369 HPFDL90 689 954333 1-193 15-207 U73330. HPFDS59 690 655543 1-267 15-281 AC004111. HPFDT17 691 581133 1-359 15-373 HPFDT54 692 655530 1-310 15-324 AA593648. HPFDT61 693 974569 1-345 15-359 HPFDU30 694 522113 1-357 15-371 AL079301, and AC004530. HPFDU38 695 867879 1-365 15-379 HPFDU59 696 739617 1-357 15-371 AC005225, AL049835, and AL031297. HPFDV71 697 867870 1-680 15-694 AW303098, AI061313, AI251203, AI251284, AI250552, AL046519, AI284543, T74524, AI223626, H07953, AI206841, AI254770, AI189682, AW023111, AI826761, AI357823, AI251034, AI249853, AA572813, AI375542, AI755202, AI066646, AW410409, AA129746, AI732430, AA757661, AW276678, AI679759, AW149288, AI635819, AI355007, AW439703, AI491765, AI753113, AW237905, AI149537, AA702637, AI864500, AI334443, AW192179, AL038936, AA904211, AI587583, AA614214, AI247101, AL031730, AC002316, AL031311, AL022328, AC007055, AL022326, AC006965, AL109865, AF109907, AC005081, AL034343, AC005592, AL133485, AL049538, AL022238, AC005355, AC005011, AC007358, AC005291, AL049540, AC008123, AP000688, AC004491, AL080243, AC008372, AL133445, AC003043, AC004685, AC005874, AF134471, AP000501, AF111167, Z83844, AC004675, AL049780, AF088219, AC006552, AJ011930, AC007277, AC005330, AC007243, AC006046, AC004686, AC005363, AC005209, AC005231, AC005746, Z97056, AL135960, AJ131016, AC004883, AC005619, AC005189, AC002430, AP000511, AL032821, AC006213, AF134726, AC007384, AC006130, U91326, AC002544, AC004084, AC004067, AL121603, AC005519, AC005899, AC004821, AF031078, AC008064, AJ010770, AC002369, AF030876, AC009731, AC005844, AC009510, AL031228, AC005406, AL079352, AC005884, AL022721, AL022476, AL049795, AC004879, AC005821, AL049760, AC005234, AC004593, AC007129, AC016830, AP000031, AL023284, X55927, AC006960, AC006203, AC005911, AF001548, AC010202, AC005368, U07563, AC004542, AL096701, AC006241, Z98750, AC005015, AC004656, AF015416, AF001549, Z82171, AC002350, AP000134, AP000212, AP000030, U91325, AC007385, D84401, AC002404, AC007637, AC006511, AC006480, AL031803, AC005606, AC002347, AC000115, AC005829, AF031076, AL031281, AF053356, AC004051, AL096791, AC005072, AL049758, AL133353, AC005565, AC016027, AC003101, AC005531, AC004990, AF001552, AL121652, AC004517, AL117351, AC007011, AC004033, U95742, AC003109, Z70280, Z83845, AC004147, AC007216, AC004805, AC006079, Z84470, AC005747, AC005225, AB023048, AC005099, AC005500, AC004526, AC005701, D87675, AC004841, AC005722, AF111168, AC007041, AC004963, AC004385, AC004131, Z98200, AL031659, AL121653, AL050318, AC006538, AL078581, AC007731, AC007253, AL008582, AB011399, AL022323, Z98949, AC004129, Z97054, AL117344, AP000151, AL022165, AC004893, AC007684, AC005050, AC000052, AC006946, AC006139, U78027, AL049557, AC005409, AL021026, AC006121, AC005726, AC005512, AC004230, AL133448, AC007406, AC005696, AP001052, AC005154, AF196779, AC007225, AL049712, AF165926, AC004222, Z84480, AP000010, AB016897, AC005921, AC002300, AL034374, AC004125, AC009247, AL021808, AL008723, AC006211, AC003026, Y18000, AL009181, AL031584, Z69905, AP000359, AC004976, U18394, AC004770, and AP000962. HPFDX13 698 655571 1-641 15-655 W67821, AI934358, AW183528, N55430, AW008575, W67636, AA825800, and N55148. HPFDZ20 699 655764 1-328 15-342 HPFEA08 700 960372 1-386 15-400 Z82203. HPFEA32 701 925499 1-295 15-309 HPFMA06 702 953536 1-213 15-227 AJ559365, N40914, AI275689, AJ769835, AI935795, AW016872, AA528426, N90231, AI041472, AI074180, AI151237, N40445, AI016719, AI352160, AA828194, H09741, AI982675, AI628382, AI912707, AA918026, N35976, AA460976, AI742265, AA151707, AI191783, AA165615, W74067, AI167928, AA937011, AA724886, R01930, AI863504, AI346991, AI309905, AA992772, AA946858, AI521733, AA055546, AA829079, AI867798, AI636334, AI636278, AA101634, AA992190, AI573041, AA044901, AA128910, N94816, AA708943, AA609789, AA041398, AI056570, AI539174, AI571014, AI318378, AA443890, AI609286, AW235575, AJ768743, AA903691, AW028229, AA773169, AI337984, AW273159, AI571376, N33273, AI498347, AW103657, AI824744, H97981, AI433353, AI250273, AI189253, W74059, AI277240, AI200413, AA024491, AW262540, AI767595, AI269009, AI805098, N69196, AI768580, AI689518, AA570675, AA374175, W37740, AA594795, AW088741, AW197140, AA165407, AA165437, AA604629, AI744021, AA780710, AA581888, AA722100, N66617, N30750, N25542, N26634, D61746, AI364247, AI363458, AI719503, Z39345, AA165599, H89567, F04672, AI708771, N91853, AI654339, AI719808, F10645, N71113, AA044690, AI695775, D51138, H89566, AI828511, AI423935, D19831, AI364605, R38667, AA461285, D51197, AI913698, T62947, D62512, AA063398, AI766125, T31394, AL133241, AL009179, and AC008126. HPFML02 703 917775 1-102 15-116 AI535639, Z33559, Z32887, T18597, AI541356, C14228, D59751, AI557864, D50992, AI526078, AI557084, AI541205, AI536138, AA492147, AI535660, AI557262, AI540903, AI557082, AI557474, AI525302, AI525500, AI525556, AI557533, AA058620, AI557317, AI525316, AI557809, AI541075, AI557155, H65400, AI541321, AI541365, AI525757, AI557312, AI557602, AI557731, AI525852, AI525661, AI541353, AI541034, R29657, AI525856, AI557258, N71206, AI536150, AI557810, AI541450, AI541346, AI557238, AI540974, AI546829, D30843, AI535828, AI557543, AI535813, AI536070, AI535994, AI557039, AI541154, AI547177, AI557041, AI557408, AI541027, AI541048, AI557154, U45328, AR050070, A62300, A62298, A82595, A82593, U94592, Z30183, AF006072, and AR025466. HPIAE79 704 655748 1-382 15-396 HPIAO83 705 655595 1-413 15-427 HPIAQ49 706 919469 1-424 15-438 HPIAQ76 707 655573 1-47 15-61 HPIA540 708 928614 1-450 15-464 AA195825, AA306492, AA418582, C16647, AW160459, AA309024, AA308183, AI571333, AA738174, AA195976, AI570688, AA612815, AA995713, AA418567, AI376546, AA977055, AW162470, AA575997, AA083678, AA100585, R35954, AA643289, AI566298, AI094772, F00910, AI282111, AA492519, AI564065, AA676682, AA622171, AA378734, R35925, AA884373, AI138493, AA156573, AA111863, AI305825, AA553893, AI557187, AA618507, AA469352, AA159175, AI266155, AA469274, N74960, AA412547, W05658, N39508, AA658912, AA083301, AA328913, F26029, AF088991, AF044954, AF067169, AC005363, AC005606, X63224, AF088992, and AF088993. HPIAV80 709 615007 1-211 15-225 HPIAX11 710 925424 1-596 15-610 AA312500, AA354863, AA319616, T69203, AA491370, H16422, AW403746, and AL031427. HPIAZ37 711 655753 1-300 15-314 HPIBQ37 712 884289 1-411 15-425 AA101561, W76302, C17760, AA227408, AA215609, AA101519, AA626769, AA359412, T73746, AI927392, AF111713, A91701, A91699, AF207907, AF172398, AF154005, and AB017568. HPIBR51 713 725539 1-454 15-468 HPIBT49 714 655719 1-426 15-440 HPIBY65 715 655757 1-421 15-435 HPICC89 716 786117 1-400 15-414 R43644, AA953944, and AL035454. HPJAB19 717 655540 1-191 15-205 AA741301, AA331014, AA461592, AI300413, AI342786, H42893, AI302277, AW407007, AI018726, AW157173, AW162314, AW162332, AW168699, R71796, AA657910, AI818313, AA429481, AA633068, AW082076, AL041733, AI471455, AI687343, AI473671, AI963816, H86579, AA225239, H30595, H30568, AA018923, AA012829, AI290145, AI459866, AA643451, AL037006, F35902, AI679759, AW392414, AA084595, AI474085, AI476386, AI925462, AI440243, AA092862, W45457, AI951112, AI620045, AI183426, AA225630, AI167360, H99222, N21300, AA992562, AW190925, AI936229, AW080772, AA829669, AI376239, AI017733, AL039117, AA381880, AW105346, AA112864, C14599, F26285, AA587536, H27788, AA904211, AA827383, AW019964, AW262466, AI799260, AI860535, AA460880, AA643441, AI962050, AI917271, AA604149, AI358557, AI032411, AI131261, AW162303, AA362440, AW162047, AW247089, AA132929, AI341664, AW161786, AA339789, AA339592, AA507990, X84712, AI902426, AA025083, AI873916, AI955029, H74309, AA578590, M85711, AI620266, AA608635, AI357628, AI345256, AI066646, AI049680, AI471476, AA019043, AI475164, H94979, AA829693, AW130427, AI755202, AI523813, AI311796, AA828154, AI267356, C14880, AA665123, AI065031, AL096791, AL034548, AL032821, AB014079, AC004991, AC007263, AL031732, AL109827, AL034549, AC004542, AP000352, AP000514, AC006139, AC008132, AC006991, AC007320, AC002088, AC004743, AC007637, AC006487, AC005971, AC004167, AF124523, AP000552, AL121754, U95740, U91323, AL050350, AL021706, AC004051, AC006160, AP000133, AP000211, AL021391, AD000813, AL049761, AC007993, AL133445, AC003693, AL049766, AB011399, AC005227, Z93784, AC006430, AC004526, AC002465, AL035072, AP000023, AC004918, AC000097, AC007664, AC006547, AB016897, AC000118, AC006084, AL024509, AP000248, AC004466, AC006322, U89335, AC010170, AL031587, AC005293, AC005208, AJ006345, AC006515, AC004805, AC003682, AC005291, AC005104, AC006251, AC004100, AF109907, AC005018, AL035588, Z97876, AP000550, AC004882, AC005949, AC005553, AC008018, AC005375, AC004478, AL031728, AC006947, AL022343, AC003002, AP000567, AL049839, AF178030, AF064858, AC006006, AL035423, AF205588, AC006236, AC007528, AL008718, AC004076, AC005225, AC004876, AC004874, AC005529, AC001231, AJ010770, AL139165, AC007312, AC005516, AP000143, AC007401, AC000083, AL049713, AC007676, AL034379, AP000090, AL031283, AC005899, AL132708, AP000210, AP000132, AF001549, AC011718, AC005046, AB020867, AL034423, AL080250, AC005011, AC010072, AC005664, AL049830, AC007773, AL121653, AC009288, Z83822, Z84487, AC005598, AL035249, K03021, AC005184, AC008000, AC006432, AC004765, AL021707, AC006441, AC004695, AL096774, D87675, AC004013, AC005183, AP000563, AL078638, AC005007, AF049895, AC003972, AC000353, AC002347, AL035461, AC004671, U73630, AC002115, AC006064, AL022318, AC004797, AC008009, AC005755, AC005589, AL049548, U07000, AF196971, AC006948, AF069291, AL031803, AC005390, AC005952, AC006254, AC004985, AC005920, AL121748, AL022396, AC005332, AC005049, AP000256, AP000566, AP000098, AC004686, Z85996, AC007436, AC006581, AL049828, Z73496, AP000052, AP000018, AP000160, AC004605, AC007731, AC007955, AC007385, AC005500, AC005192, Z83846, AC005041, AC004838, AC005480, AC003010, AC004962, AL049832, AL121838, AP000556, AC005027, AC004864, AC004539, AC005565, Z94801, AL049569, AC006538, AC006210, AC003106, AL035415, and AC000120. HPJAB84 718 655531 1-314 15-328 HPJAC36 719 655601 1-401 15-415 AI167181. HPJAC92 720 867831 1-338 15-352 HPJAD09 721 655712 1-329 15-343 AL080239. HPJAD66 722 655694 1-276 15-290 Z83851. HPJAD82 723 655765 1-237 15-251 AI979243, and AI967993. HPJAV07 724 952852 1-321 15-335 HPJAW56 725 823393 1-757 15-771 T93943, T93893, AA399372, and T81024. HPJBI17 726 655761 1-417 15-431 HPJBI89 727 655708 1-69 15-83 AC006071. HPJBK52 728 655751 1-249 15-263 AW275406, and AC000378. HPJBU08 729 958979 1-351 15-365 HPJBV17 730 655729 1-286 15-300 HPJCC04 731 926787 1-357 15-371 AF108195, AF159714, AF186379, AF106698, AB025784, and AF049330. HPJCP10 732 964259 1-421 15-435 HPJCP11 733 966676 1-325 15-339 T08031, and AB011095. HPJC584 734 590404 1-333 15-347 AP000494. HPJCV50 735 968095 1-535 15-549 AC005923. HPJCX15 736 655730 1-320 15-334 HPJCX26 737 655600 1-337 15-351 HPJCY70 738 655569 1-218 15-232 HPJCZ03 739 922850 1-171 15-185 HPJCZ06 740 934170 1-278 15-292 AI133297, AW163293, AW303196, AA191659, AW080777, AW084466, AI499588, AA279421, AA548890, AA431949, AA486131, AW301350, AA457070, H71429, AI040342, AW275510, H52274, AL133909, H82316, AI250083, AA661921, AW102846, AL042420, AI953275, AA476397, AI766906, M77893, AA630672, AI205010, AI284640, AL038498, C18550, AA320966, AA579179, AI393931, AA114983, AA774780, AL119713, AI002720, AW274349, AA508359, AI818231, AI271164, AA838190, AI806102, AA577824, AA385798, AI708009, AA578327, AI889566, AA832188, AI499301, AI801482, AI298061, T92347, AW103927, AA984295, AA558884, AA055871, AI733755, AA584876, AA504877, AA127426, AA669155, H09071, AI805363, AI203925, N23504, AA101689, AW104793, AI168167, AI694130, AA572971, AI950983, AI056913, AI345157, AI924872, AW316873, AL046689, AA653857, AA323701, AA772851, AA526787, AA778992, R64559, R95448, AA490183, H49568, AW022897, AA402129, AA493695, AA834707, AA738253, AA719073, T99179, AL035209, AL035450, AC000119, AC002529, AL133371, AC002310, AC007446, AC007845, AC002127, AJ003147, AC007652, AL031053, AC005215, AC003100, AC004638, AC006314, AL033523, AC002416, AC006466, AC006112, AC006312, AC005998, AC004745, U57009, AL049773, AL049733, AC006989, AC012599, AL035608, X53548, AC004161, X54175, D83989, AC005258, AC005072, AC006478, Z98750, AC006539, AL1 21653, AC004895, AL023799, AC005026, AC0072 14, AC002350, AC007437, AC006238, AL022 163, Z82 170, AC002300, AC006045, X76666, AC003965, AC004030, AC004940, Z83733, AL024506, AP000967, AL049565, AC006963, AC002527, AL049749, AL032822, AP000204, AP0G0 126, AC00591 1, AL080241, AL021155, AL034395, AC005162, AL031630, AF227510, AC005048, AC004675, Z82214, AC007228, AC003977, AC004592, Z95 113, AC004047, U623 17, AC002430, AL121603, AC007193, AC006058, AP000244, AC006195, AF042090, AC018767, AC007384, AC007406, AF123462, AF088219, AL031054, AC007298, AC002385, U66059, AC008372, AC007564, AC006071, AC005839, AL035633, AL049649, AL022170, AL050326, AC007848, AL022166, AC004594, AP000950, AC007360, AC000066, AP000081, Z99497, AC007043, AC007243, AJ010770, AC005066, AC002559, Y09781, AL023879, AC004028, AC003683, AC004525, Z84487, AC005154, AC006374, AC007436, AC005774, AC011362, AP000962, AC005725, AF012654, X55926, AC005011, Z73417, AC004224, AC004756, Z99569, Z82193, AC004987, AC004865, AL035455, AL021918, AC007387, AL096701, AL022721, AC006369, AF001549, M22900, AC002115, AC006479, AC007955, AP000348, AL121934, AL035462, AP000563, AP000275, AC002466, AC005480, AP000037, AP000105, AP000211, AP000133, AP000201, AL049550, Z98753, AL031259, AP000097, AL033377, AC007023, AL022316, AC005940, AC004098, AL023284, AP000240, AL049781, AC006239, AC006211, AL078634, Z69838, AC004262, AC005233, AL096776, AC005301, AC007064, AC005534, AC010202, AL008718, AC007682, AL034384, AC005412, K00063, U67233, AC007510, X78081, AC006005, AC005200, AC005213, AC005226, AJ239322, AC005138, AL049557, Z84483, U95742, AC007041, AJ133269, AC006213, AL049853, AC007263, Z69922, AC005032, AL031721, AC005952, AC005490, AC004210, AL021977, AL031186, AF002994, AL021546, AF009660, U69730, AC004948, AC005363, Z98051, AC004502, Y07848, AC005606, AL008728, AF003626, AC006974, AC005250, AL096770, AP000508, AP000020, AP000161, AL008731, AL034374, AP000359, AC006004, AC004548, AC004132, AL031774, and AC005091. HPJDA08 741 958182 1-1026 15-1040 AJ003623, and AB033053. HPJDJ58 742 906904 1-557 15-571 HPJDP05 743 931027 1-607 15-621 HPJDX94 744 838748 1-237 15-251 HPJEE38 745 954970 1-778 15-792 AI371073, AI219866, AA994007, AI624792, AA455079, AA731668, and AI357531. HPJEI55 746 926815 1-218 15-232 HPJEJ39 747 930988 1-534 15-548 AL121576. HPJEQ04 748 927618 1-353 15-367 N31776, D81937, AA308517, W24026, AA188787, T85662, AA486505, AA296183, AA371449, AA480085, H68032, AI905771, N24360, AI557456, AA378402, N44103, AJ230778, N36604, R06524, AA315510, R96861, AW405225, AA377571, AW405277, AA331149, AA317807, T81882, AA113774, AA491834, N55922, AA114293, AA312037, H15644, AA349981, AA350397, R12355, AI815626, AA315400, AW405355, N87264, AI929151, AW160663 AA378061, AW163412, T80452, AA314941, AA314112, AI929706, AW411183, AW406481, H78627, R35762, AA357940, AI929710, N56557, AA358387, C03712, AA339645, AA135815, AA211277, AA306543, T82235, H73536, AI133457, W46178, AA481926, W95766, R25753, AA135170, AA095966, AI278664, AA069646, AA046483, AA333829, AA383525, AA089954, AA188820, AA196885, W46472, AA091086, AW405268, T94167, H73790, AW406536, W44612, R32549, AA206938, AW405651, R32535, N99534, AA094637, AW406320, T77143, AW406699, N80654, H66547, H38190, W47474, H89815, AI174721, AA360029, AW406684, AI110648, N79200, AW406674, W60906, AW405310, AA338579, W25182, C02931, AA331216, AI336620, R37281, H15645, AA961815, AI651492, AA385664, AA091960, T76978, H80216, AA039312, R39058, AA857214, and AA350396. HPJEQ22 749 867725 1-629 15-643 HPJET90 750 836503 1-542 15-556 T03269, D58283, D80022, D80195, D80193, D59927, D51423, D59619, D80210, D51799, D80391, D80240, D81030, D80253, D80227, D80196, D80188, D59275, D80219, D80366, D80043, D80038, D59859, D80166, D80212, AI905856, D80269, D50995, D59889, C14429, D50979, D80134, D80378, D80024, D80045, C75259, AW178893, C14014, D59502, D57483, D59787, D59610, D51097, D80164, D80241, F13647, D80268, C14331, D51060, AW177440, D58253, C15076, D59467, D80949, D80168, C14227, AA305409, AW378532, AW178775, AW179328, C14389, AW352117, AW352158, AW177501, AW177511, D51079, AW178762, D51022, AW366296, AW360811, AW176467, AW375405, AA305578, AW377671, D59695, AW179220, AW360844, AW360817, D81026, AW375406, D80248, AW378534, AW179332, AW377672, AW179023, AW178905, AA514188, D52291, D80251, D80132, AW352170, AW352171, D80522, AW377676, AW177731, AW178907, AW179019, AW179024, AA514186, D80133, AW178906, AW177505, AW179020, AW178909, AW177456, AW179329, AW178980, AW177733, AW378528, AW178908, AW178754, AW179018, AW179004, AW178914, AW178911, AW367967, AA033512, AW352174, D80302, AW178774, AW177723, D80439, D80247, T48593, AW178983, D51103, AI535850, AW367950, C14975, AW178986, D45260, A67220, A62300, A62298, D34614, D26022, X67155, A25909, A84916, D89785, A78862, AR025207, D88547, AJ132110, AB012117, Y17188, A85396, AR066482, X82626, A85477, A86792, X93549, I19525, A44171, AR018138, X68127, AF135125, U87250, AF058696, AR008278, Y12724, AB028859, AR064240, A94995, D88507, AR008443, AB033111, I18367, I50126, I50132, I50128, I50133, AR066488, A82595, AR066490, AR016514, D50010, D13509, AR060138, A45456, A26615, AR052274, Y09669, AR060385, AB002449, AR066487, A43192, Z32749, A43190, AR038669, A30438, AR008408, U87247, U79457, AB023656, AR060133, X93535, and AR008382. HPJEV06 751 934096 1-504 15-518 HPLAN47 752 717680 1-488 15-502 R77414, R76671, R69252, R76677, R32705, R68709, R62204, H68658, R66563, R69804, H79604, R79061, R28309, H78098, R80677, H13421, H12467, R28193, R26740, R63675, R79115, R28382, R26685, R71045, R80483, AI147439, AA367784, R67876, R75656, R62719, N45236, AI685384, AW074013, AI744897, AI682985, AI830819, AI051767, AW298380 AA429290, AI672705, R79114, H28769, AI961748, AI719461, AA411112, AA292246, AA411111, AA565430, R32518, H03930, AA428704, AA235525, AI244500, AA367885, AW081078, R94826, AW135966, R69938, H13465, H78097, R24254, AI962580, AI656685, R63981, T95910, R76350, R23579, AI765947, R81427, R22392, AA236697, AI096455, T24700, AA430655, R28308, AA564171, R23234, AA811964, AA177137, AA483918, H68983, H00975, R32651, H12520, R28594, AA806843, AA292545, R25221, AA744128, AA640543, AA427477, H79603, AA320868, R77413, AA377663, AA525377, H90432, H03929, R69134, H70222, R26973, AA329358, T35477, T31730, T34672, D81451, T19025, AA143133, AA902113, H08404, H08284, R52419, AA902115, R35278, R59021, R36040, Z43118, AF085838, AC005281, AP000884, D28589, AC007114, and AL110197. HPLAR41 753 557554 1-278 15-292 AA367867, AA367898, D58066, AA385928, AA610791, AI803229, AI004961, AA298314, AW157413, AI291353, F35348, AL041411, AA663300, AA132536, AI990650, AW139132, N94967, AI290861, AI961193, AA584498, AA657353, AA081993, H96719, AI025602, AA501873, C17730, AA911409, H04879, AA055654, AI250812, AI921101, AI925647, AI559442, AI955464, AA508451, AA946637, AI632138, AW102963, AI568919, AA659014, AI872191, AA862481, AI869945, AI871616, AI538654, AI902795, W45291, W58428, AA166854, AA629837, AA460715, AA092309, AA287329, AI952804, AA176355, AA130476, AI817158, AA767353, AI285660, F16040, AA932087, AI246569, AW262471, N77920, AI862212, AA811111, AI819528, AA864823, AJ601265, AI858607, R33901, AI524900, AA771730, AA771711, AI336355, F33397, AA347740, AI421777, N79992, AI499286, AI440018, AW272376, AI453790, N31608, N33132, N20064, AI375417, AI540098, N30146, AI310239, AA364962, AI591332, AA132716, AI628308, N90055, W19865, AA830701, AA129986, AL044349, AI271865, AI457328, AI027421, AA807609, AW085676, AI376984, AL038713, AL119517, AA136576, AI095849, AI082077, N24958, AA961590, H06476, AA779937, AI028382, AA309496, AA091111, AI827493, H01157, AW419031, AA492106, AI088245, AW272291, T48029, AW072619, AA136630, AA099788, AI733728, AL034400, AF030186, AC005350, AL031294, AB020871, AC005852, AC005688, AC006363, Z95328, AC004910, AC002448, AL022151, AF064862, AC004081, AL137191, AC007262, AC004384, AL133233, AL049871, AC006559, AL136504, AP000079, AC006989, AC002524, AC007444, AF002997, AC001604, AC001157, AC005579, AL023582, AC008165, AC006525, AL021307, U60822, AC003083, Z96811, AC010196, AC000114, AC005988, AL096699, AL035089, Z83313, AL096706, AC007736, AL023806, AC003073, Z69721, AC005603, AP000265, Z73497, AC000021, AC005604, AL035666, AC005487, AL079334, AC002071, AC006981, AL022308, AC004452, AF164343, AC006963, AL049562, AC005994, AC004924, AC007286, AL022100, AC002564, AL078601, AL035608, AL096799, AP000078, AP000019, AP000161, AP000126, AP000204, AP000034, AP000101, AC004048, AL031780, AC008174, Z82212, AC004519, AL023798, AC000403, AL049792, AL049611, AC003086, AL031446, AC004054, AC004614, AC002551, AL109620, AL030998, AC005884, AF196972, AC003085, Z83822, AL049734, AC005856, AF165138, AC004944, AC004047, AC004837, AC006355, AL021919, AC004648, AC007628, AC006054, AC004960, AC005993, AC018833, AC003668, AL022577, AC006500, AC003081, AP000244, AC004970, AC005668, Z93019, AC006332, AC004911, AC004626, AC010722, AL035251, AC005249, AC006050, AC006382, AC004065, AC007876, AC006230, AC005552, AC009514, AC006370, AC007486, AF123462, L29074, AL117340, AL049835, AC005019, AL079305, AC005832, AC007207, AL132985, AL139165, AL034384, AC004388, AF130343, Z95325, AC006222, AC007023, AL049588, AC002412, U95743, AC010072, AL033525, AP000542, AC007785, Z81145, AF008243, Z75896, AC001642, AC000368, U69569, Z73361, AC004523, AC004201, AC005584, U69729, AC005689, AC004536, Z98749, AC002545, AF198097, Z92546, AL031176, AC005355, AB026899, AL096757, AL135784, AF130249, AP000499, AP000018, AP000518, AP000160, AL109611, AC004225, AC012380, AF188024, AC004748, AL096862, AL030995, Z82196, AC004259, AC005741, AC003051, AC006463, AC006084, AP000353, AC002402, AC004600, AC005858, AL033504, AJ010598, AL031650, Z82206, AL022720, AL022345, AC004738, Z77249, Z74696, U82672, AC006353, AC004746, AL033403, AC005345, AB023054, AC004894, AC006199, AP000457, AC006366, AC005082, AC006991, AC010183, AC006257, AC011362, AC004887, AC006427, AC007250, U82828, AL022726, AC006313, AC005740, AL109865, Z93242, AL050308, AL050317, AP000500, AF011889, AC007392, U01308, M22332, AL033533, AC005885, AC006479, K01669, U96409, U08211, AC007350, M22334, and L24756. HPLBB50 754 503751 1-292 15-306 AA368037, and AA368044. HPLBL31 755 503732 1-349 15-363 AA368423, and AA368422. HPLBL57 756 503730 1-261 15-275 AA303008, AA303009, and AC002427. HPLB061 757 558187 1-229 15-243 AA368593, AA758725, and D86985. HPMAG19 758 705471 1-290 15-304 AA369206, AA369215, AW276918, AI498304, AI859717, AI635381, AI873828, AI806367, AA992384, AI651551, AI073771, N26890, AI479551, AA287708, AI628336, N21211, AI942382, AA553615, AA479887, AW085308, AW137286, AA873472, AA679635, AA586824, AA708432, and AB023229. HPMAH75 759 766443 1-301 15-315 AA303039, AA369332, AA335519, AA553332, AA745302, N63749, Z95331, AC003682, AL022327, AC005488, AL035685, AL031587, AC004856, AC005015, AC005899, AL109628, Z98884, AL035684, AL031589, AC003030, AL133245, AC007842, AC007685, AC005231, AL133163, AL049759, AC005788, AL109801, AL031283, AC005412, AL049874, and AC002349. HPMBK34 760 954057 1-374 15-388 AA662989, AA668148, AA513884, AI912401, AA303131, AA077247, AA654482, AA493618, AL038527, AI872000, AW105463, AA515351, AA744423, AI590404, F26713, R48980, AW273146, AW273201, AA309232, AI439393, AI926656, H43771, AA631515, AA569715, AI929796, AI798407, AW194077, AA758131, AW157731, AA488903, AW162750, AW003612, AC005940, AC007240, AC005519, Z83840, AC006455, AC005899, AC005482, AL022322, AP000555, Z83822, Z83844, AC007358, AL031255, AC005280, AP000347, AL022313, AC005722, Z98051, AL035415, AL121653, AC005300, AC004084, AC007193, U95742, AL049709, U95739, AL049835, AC007216, AL022329, AL034419, AC002301, AF111169, AC005412, AC004878, Z83843, AC004253, AC000353, AC002477, AC003026, AC005207, AC007435, AF027390, AL008725, AC010205, AC004991, AC008116, AC005829, AP000694, AC005409, AC002425, AP000512, AC006011, AL135744, AL031588, AC005971, AC005529, AC007227, AL031651, AE000658, AC004887, AC002544, AC007308, AF001548, AP000553, AC004019, AP000008, AP000501, AC002300, Z83820, AC004386, AC005015, AB023049, AC004491, AP000704, AC005086, AC004702, AC006372, AC002351, AC002059, AL050318, AC006126, AL132777, Z95114, AF109907, AC005332, AC009247, U95740, AC005102, AC008115, AC004805, AC006285, AC007731, AC006039, AC005839, AC016830, AC006459, AF196970, AC006509, AB023048, AL022238, AP001063, AC006468, AC002470, Z98036, AL008718, AC005088, AC005527, AC006449, AD000092, AC007421, AC007649, AC005484, U47924, AL109758, AL035249, AL139054, Z95113, AF196779, AC006057, AC004517, AC005072, AC005859, AC008012, AL022237, AC007073, AL049552, AC005696, AP000503, AC005089, AF107885, AC005500, AP000692, AC004876, AC005411, AL035587, AC005803, AC005520, AL023575, AC004263, AL022323, AP000504, AC006992, AF029308, AC000052, AC007880, AL133163, AJ003147, AC005746, AC006111, AC007387, AC007276, AC005695, AC008125, AF129756, AC007226, AC004938, Z83838, Z93017, AL035419, AC007011, AC004169, AC005355, AC004382, AL035659, AC005377, AF196972, AL031282, AC008015, AL049697, AP000689, AL031577, AL031291, AC005914, AP000123, AP000055, AP000170, AC005049, AC006120, AF134726, AC003101, AC005005, U52112, AL022316, AC005225, AC007934, Z97054, Z82189, AP000510, AC002094, AC005261, AC007546, AL031123, AC004686, AC007685, AL034548, AC004801, AC003043, AL023513, AC005895, AL117258, AL035684, AL031295, U73024, AC005516, AC004583, Z97055, AC002418, AL031311, AP000346, AC003663, AC004813, AC002400, AC006515, AC007450, AC005383, AC002992, AL121655, AD000864, U91321, AB003151, AC006441, AC006241, AL024509, AC005486, AL035405, AL035691, Z85996, and AL031650. HPMBK49 761 577661 1-416 15-430 AA253119, and AA256187. HPMBM48 762 575626 1-489 15-503 HPMBN02 763 920865 1-106 15-120 AL031848. HPMBO10 764 968365 1-349 15-363 HPMBO61 765 867677 1-431 15-445 AL133650. HPMBR17 766 785732 1-415 15-429 HPMBU81 767 557870 1-470 15-484 HPMBX35 768 531058 1-195 15-209 HPMBX79 769 577637 1-372 15-386 HPMBY76 770 531338 1-332 15-346 HPMBY83 771 527006 1-428 15-442 AI590323, AW379794, and AW379800. HPMBZ05 772 932527 1-211 15-225 HPMCB65 773 531289 1-403 15-417 T47761. HPMCC73 774 531066 1-301 15-315 HPMCD77 775 529960 1-266 15-280 AI141166, AL040565, and AP000495. HPMCI02 776 381961 1-416 15-430 R53558, AW183662, AI936591, AI554166, Z39384, and AI658791. HPMCI65 777 577598 1-275 15-289 HPMCJ14 778 524768 1-393 15-407 AC000105, AL031591, and AC004032. HPMCJ19 779 531279 1-241 15-255 HPMCJ48 780 577601 1-291 15-305 HPMCK65 781 742095 1-319 15-333 H64820, AA092052, and AL023807. HPMCS19 782 954056 1-195 15-209 AW136091, and AL031710. HPMCS65 783 961250 1-120 15-134 AC005923. HPMCV93 784 657532 1-429 15-443 AA128929, R11967, T78064, AA449505, T74763, and AB018281. HPMCW25 785 867673 1-630 15-644 AA429660, AI375673, AI656667, AA320869, and AI222277. HPMCW53 786 727392 1-190 15-204 HPMCX11 787 967655 1-300 15-314 AW029019. HPMCY30 788 867687 1-344 15-358 HPMCY31 789 725180 1-325 15-339 AA113940. HPMCY35 790 571411 1-637 15-651 T95994, and AW440904. HPMDJ09 791 582594 1-290 15-304 HPMDL78 792 577590 1-340 15-354 AF111168. HPMDO39 793 531275 1-192 15-206 HPMDR07 794 867682 1-285 15-299 HPMDT91 795 745346 1-334 15-348 HPMDU19 796 577626 1-313 15-327 N69438, N71427, N62439, H80350, R83031, H66851, H67489, R62741, AA918030, H54212, and AC005281. HPMDY52 797 531274 1-39 15-53 HPMDZ62 798 531276 1-360 15-374 HPMBB66 799 531349 1-397 15-411 AC006500. HPMEC16 800 867658 1-299 15-313 HPMEC36 801 668897 1-333 15-347 HPMEC69 802 702501 1-270 15-284 N20192, and AC008123. HPMED52 803 531347 1-438 15-452 AI906494, and AC005004. HPMEE48 804 531321 1-428 15-442 AC007966. HPMEE66 805 577619 1-323 15-337 HPMEG50 806 925080 1-140 15-154 HPMEI39 807 784781 1-704 15-718 AA029876, AA029112, AI089387, W80831, H23039, AA314213, AA209372, AA209368, H55702, AA304885, AI218927, AL021707, AL050345, AJ236698, AL080313, and AC006441. HPMFB02 808 920308 1-391 15-405 AW197446, AI972578, AI657152, AW204366, AA436769, AA442937, AI261197, AA421160, AA034360, and AI675734. HPMFB28 809 575934 1-327 15-341 HPMFB37 810 575620 1-648 15-662 T58945, T58884, and AI352293. HPMFB75 811 526594 1-220 15-234 F19258, AW419161, AW438916, AI205126, AA077817, AI565245, F35659, AA318652, AA551509, N87410, W60516, AA515938, AW029038, AA025083, AI252554, AA743956, AI285615, AA618158, AA932099, AW275674, AW236342, AI679045, AI446601, AA177061, F29989, AL133862, AI200051, AI469641, AA631363, AL041368, AA327782, AA626637, H04821, AA745410, AI873916, AL040130, AW440976, AA501600, AI049634, AW008317, AW338500, AA441788, AW069227, AL040913, AI824562, AI633007, AA503454, AA602069, AA228420, AW207652, AI962050, AI358229, AA557879, F36373, AW166815, AW406755, AI985519, AI634187, AI365988, AA713815, AA610786, AI917271, AI457313, AL048925, AI251002, F32705, AI003743, AL042213, AI918421, AW129262, AA886584, AA484059, AL040072, AA515051, AW339687, AI246796, AI929531, H65428, AI291124, AI151261, AA515224, AA340960, AI904894, AL120008, AI499094, AW419118, AI635272, AA229785, AI291268, AI802526, AW069807, AA559290, AI521679, AI537030, AI890923, AI922002, AW162049, AW080134, AI474713, AI433187, AA501722, AI608626, H69041, AA469451, AI049722, U02048, AP000158, 875337, AL035555, Z72521, AF015162, AL031670, AC004057, A39972, U14701, AF140763, AL121603, AF017257, U14684, U14691, U14685, U14686, U14687, U14688, U14689, U14692, U14699, U14702, U14707, U14710, 575201, U14711, U14712, U14713, AP000014, U14714, U14715, AL020997, U14716, AP000692, U14717, U14718, U12580, U14719, AC005412, AL096712, AC006315, AL122020, AC004617, AC005324, Z93024, AC009241, Z94801, AL031577, AL117328, AP000497, AC007395, AC004125, AL133312, AF015167, AF015160, AL121578, AC005389, Z68192, AC005006, AF124523, AC006365, AF053356, AC007298, AL109627, AC009178, U14695, U14703, U14705, AL033521, AC005695, AJ239318, Z98752, AC002433, AC005401, AF131217, AC005765, AP000252, AL121923, AL031846, AC000052, AF111167, AC005779, AC006064, AF086558, AC005911, AL021332, AC004817, AL135960, AJ131016, AF205588, Z84477, AC004907, AJ006996, AP000212, AP000134, AL049610, AL078581, AC004841, AL022718, L81415, AL109798, AC005222, AC004694, AC006210, AC006023, AC005619, AP000031, AF015171, AC004858, AL096703, AL022328, AL139054, AC007686, U95740, AL035552, AC002558, AL034420, AJ223364, AC007541, AC004675, AC004909, AC004008, AJ246003, AC000353, U12583, AF164343, AC006313, U12581, AF002991, AF015170, S70694, AC000039, Z81309, AC007666, S70707, L35531, AF015169, Z86090, AC002465, AC005099, AC004263, AC006001, AL031587, AL049830, AC002094, AL133448, AF088219, AL121655, AL035684, Z98304, AL109980, AF015168, AF128846, AF128847, AC006299, AF120990, AF190465, S48196, AL033533, AL033527, AC005972, AL096774, AL031312, AL117355, AL009031, AC002457, U51281, Z75889, AC002326, AC006373, AC005229, Z69921, Z85989, AC007285, AL049757, AC002287, Z82246, AC004108, X62354, AC008126, AC004804, AL035681, AC004024, AL049223, AC005057, AC000392, U95743, AL035450, AC004542, X53550, AF037338, AL035410, AL022238, AL035407, AL033392, AP000512, AL031393, AC004383, Z82201, AL031118, AC007690, AF147439, AC005699, AP000193, X53795, and U40369. HPMFB84 812 577593 1-347 15-361 AA917042, AA476820, AA861762, AW197737, AA883969, AI222281, AI394043, AI476496, AI420953, AI816942, AW418714, AI337319, AI312584, AI268413, W60319, H72483, AI125256, AI198189, AI739036, Z57770, Z59847, and Z57771. HPMFE35 813 577633 1-415 15-429 AC005909. HPMFE60 814 577636 1-309 15-323 HPMFE73 815 575941 1-416 15-430 AL009031, and AC002326, HPMFH21 816 575943 1-447 15-461 HPMFJ50 817 575932 1-475 15-489 R20682, T65200, Z44442, and F11983. HPMFJ55 818 577588 1-369 15-383 HPMFL08 819 959569 1-452 15-466 AA555286, AA640814, AI281916, AW073979, AI378363, R70468, AW242350, AW013856, AA644290, AW449140, Z93016, AC012384, AL035541, AC005228, AC003662, and AC009300. HPMFL80 820 874359 1-440 15-454 AA313895, AA834888, AA362291, AW366931, AA436945, AA496034, AI834310, AA402490, AI039687, and AC004841. HPMFM29 821 582595 1-860 15-874 AA255639, R53909, AI492887, H09275, AW192355, N48929, and AL117598. HPMFN12 822 968821 1-499 15-513 HPMFP05 823 867662 1-413 15-427 HPMFP30 824 577629 1-335 15-349 AC008072. HPMFP38 825 575914 1-342 15-356 AC006121. HPMFQ84 826 867651 1-678 15-692 R31294, AI823535, AI823533, AL038977, AW271095, AI252141, AL135383, AI792856, AA594742, AW302832, AA828911, AI284536, AI251563, AI733946, AA578905, AI383596, AI733930, AL047645, AI792695, AI792746, AI792842, AI252190, AI281401, AI689198, T56025, AA553900, AA557493, AA809125, AA484022, AA219181, AJ859906, AI089178, AA551067, AI884861, AA169245, AA494047, H81918, AI798313, AI298660, AI038324, AI798569, AI869786, AW269071, AI347649, AI347478, AI761677, AA599080, AC006060, AL022318, AF111168, AL049779, AL034420, X14448, AL021978, AC007731, AC005500, AJ010598, AC000071, U78027, AC015853, AC005932, AC004033, AF001549, AL035422, AC006312, AC004263, AC004000, AC005037, AC005412, AL008715, AC005006, AC006057, AC002544, AC006088, AL133243, AL009051, AL031255, AC005828, Z85996, AC004771, AC006946, AC004527, AL031577, AC005071, AC004675, AC002470, AC002045, AC002390, AC009263, AL135744, AC004821, AC002300, AC005295, AC005952, AL022316, M26434, AF088219, AL035634, Z98941, Z97053, AC005527, AC005048, AC002106, AC007050, AC008124, AC004262, AC005363, AF015416, AC005730, AC007686, AJ006216, AB017602, AJ246003, AL031133, AF172277, AP000248, AP000704, AL096702, Z81364, AC004912, AL020997, Z83844, AB020868, AL110121, AC006023, AL035681, AL080243, AL008721, AL132987, AL121658, AL049745, AC005368, Z98742, Z85987, AL021391, AC007227, AF196972, AC000025, AL031428, AL132642, AC005520, AC005041, AL049692, AL031673, U95742, AL049776, AP000555, AL031846, AL049694, AC004143, AC002115, AC004531, AC006480, AL033517, AL132777, AC004491, AC002350, AL049872, AC007216, AC004129, L78810, AC004797, AL035398, AP000692, AC004941, AC005829, AC005529, L44140, AL022719, AL008718, AL020993, U52112, AC007676, AC006064, AC006356, AC002509, AP000047, AP000226, AF134726, AC004223, AC002477, AC004805, AP000326, Z84466, AC003689, AF030453, AC007151, AC002394, AC009464, AP000501, Y07950, AC008372, AC007566, AC004887, AL031602, AC004841, AC004150, AP000054, AP000169, AP000122, AC004812, AL049569, AC005326, AL109984, AC005323, AL031228, AC004983, AL035416, AF109907, AP000049, AC005800, AP000115, AL031311, AP000311, AC006241, AC004383, U85195, AL023876, AP000131, AP000209, AC007435, AP000087, AC005229, AL031433, Z98304, AC005088, and Z85986. HPMF541 827 711640 1-422 15-436 Z95331. HPMFT04 828 916662 1-316 15-330 HPMFU89 829 575894 1-326 15-340 HPMFV28 830 652097 1-330 15-344 AA434145, AI422195, and AC007239. HPMFV82 831 575911 1-363 15-377 AL120663. HPMFV88 832 956263 1-353 15-367 R56205, N31111, AW403866, and AA338327, HPMFW25 833 960065 1-266 15-280 HPMFW78 834 932529 1-466 15-480 C18404. HPMFX13 835 575908 1-436 15-450 AI245605, AI733581, AW195539, AA994974, and AL050350. HPMFX65 836 867657 1-341 15-355 AL031282. HPMFX70 837 577642 1-346 15-360 AC005383. HPMFX92 838 577603 1-348 15-362 AL008730. HPMGA83 839 968359 1-512 15-526 HPMGB22 840 506379 1-308 15-322 Z85999. HPMGC07 841 920313 1-367 15-381 AI214759. HPMGC23 842 703835 1-421 15-435 AA309957. HPMGE31 843 867648 1-422 15-436 HPMGE95 844 873392 1-796 15-810 HPMGF06 845 954823 1-551 15-565 AA034305, AI752781, W38450, AA295920, W69345, AW368627, W01351, AW167099, AA491113, AI093592, AI628843, AA470016, AA459627, R70436, W16698, H30472, R72510, R27103, AI986035, AI926603, H25748, AA432254, W67475, R53035, AA617710, AA865403, AA412294, AA431234, AA514353, AI002434, W69267, R37917, R24912, AA443912, H24995, R72497, and X52574. HPMGF32 846 577615 1-355 15-369 AC006960. HPMGH16 847 577641 1-402 15-416 HPMGI03 848 924521 1-387 15-401 AA308643. HPMGI84 849 920326 1-269 15-283 HPMGJ93 850 864040 1-347 15-361 AA361434. HPMGK37 851 575924 1-414 15-428 HPMGK59 852 671936 1-492 15-506 W51873, AA215789, AA215316, AI654057, AI809466, AI761758, AA292627, N24002, AI860134, AA279010, AA215628, AC003032, and Z56178. HPMGK62 853 730751 1-517 15-531 R82057, and AI828591. HPMGM33 854 854081 1-648 15-662 AA702486, AI630976, AW339792, AW418628, AI690212, AI350097, AA830893, AA703551, AI458500, AA936420, AW402861, and AB020714. HPMGM54 855 577599 1-342 15-356 AL050074. HPMGR80 856 506235 1-380 15-394 AW409684, T06413, AB003151, AP000688, and AB033064. HPMG509 857 575951 1-99 15-113 HPMG524 858 796440 1-354 15-368 HPMGT67 859 970815 1-111 15-125 HPMGV12 860 968364 1-288 15-302 HPMGV15 861 582596 1-261 15-275 HPMGV59 862 577635 1-264 15-278 AW242577. HPMGW48 863 920309 1-428 15-442 HPMGX23 864 575903 1-301 15-315 AI806968, AI080168, AI207589, AB006572, and AF09I095. HPMHA80 865 970813 1-282 15-296 AL133605. HPMHB74 866 577595 1-539 15-553 H09672, and AI937462. HPMHB83 867 531382 1-364 15-378 HPMHC74 868 577631 1-357 15-371 AL008709, and AL020990. HPMHD66 869 928433 1-429 15-443 AI247199, AW166611, AI254913, AA833896, AA833875, AA644090, AI818737, AL048466, AW069227, AI460050, R81017, AA613624, D44639, AA603530, AA307598, AW270385, AA634786, AI682665, AA468022, AL047349, AI687343, AI753113, AA528390, AW302017, AA707849, AA984187, AI925579, AA526724, AI084348, AI278972, AL040054, AI791150, AI867058, AA580808, AA633920, AW188742, AI634187, AI537458, AI004591, AA847499, AA639946, AA574442, AI591375, AA643770, H63092, AW305371, AA651632, AA837035, AA558560, AA862179, AI216990, AW270256, AA846959, AA581247, AI908093, AA626040, AA084609, AI469577, AI049955, AI720195, AW131043, AA314891, AA714011, AA456924, AA481887, AI732869, N23913, AA191418, AI635279, AW068316, AA452887, H15652, AI283312, AA176605, AA846944, AA904275, AA704393, N64587, AA834777, AA515728, AA601356, AI457313, AW440545, AI521525, N40092, F30158, AA493226, AA364453, AA583394, AI537020, AA229975, AA521323, AI244127, AA837671, W01985, AI962030, AI580707, AW265138, AA521399, AA086318, AI344948, AA362349, AI302994, AI524360, AA806796, AA721645, AC000025, AC004796, AC005736, AC005081, AC005899, L78810, AB026906, AC005581, AC004382, AL133448, AC006241, AC004000, U96629, AL096703, Z98884, AL133245, AL035685, AC006077, AC005844, AC004098, AC007227, AC004876, AC005746, AC004686, AL078604, AL033517, AL023807, AF196969, Z99755, AC005180, AC005800, AC016025, AL022313, AL132777, AC004253, Z97181, AC004881, Z82172, AC004973, AC004890, AC002110, AL079305, AC003663, AL132985, AC005632, AC006047, AC004019, AL031846, AC007327, Z84482, AP000313, AC002104, AC004913, AP000299, AC005102, AC004447, AC005725, AC000120, AC007666, AP000066, AC006014, Z71183, AC004476, AP000193, Z99716, U62293, Z93023, AC005619, AC000052, AL034429, AC005089, AC006441, AL031311, AC005783, AL080243, AC010170, AP000050, AF053356, AL024507, AF134726, AL035494, AC005768, AL031662, Z83844, AC005231, U47924, U41193, AC005740, AF111169, Z81364, AP000117, AP000269, AC005920, AC006197, AP000689, AL020993, AL133445, AC004895, AC008085, AP000503, AF165926, AC002350, AL049538, AC004854, AC004859, AC007308, L81690, AC005488, AP000509, AC002470, AL121769, AL031587, AP000I03, AC005943, AC004882, AF129078, U52112, AC006276, AB003151, AC005940, AL035697, AL117338, AC005972, AC000004, AC007878, AC005664, AC005690, AP000113,AC006285, AC006515, AC003101, AL022323, AF030453, AL117258, AP000045, AD000092, AL008710, Z98200, AL035458, AL109627, AC006368, AC005529, AC004383, AC005015, AC007766, AF129756, AL035691, AC005088, AC004797, AC000028, AC002492, AC003006, AC006509, AC005610, AC002303, AC008123, AL034420, L44140, S54074, AC005839, AC006059, AL049829, AL117355, AC008082, AL096701, AC006040, AC004887, AC006111, AL022163, AC006254, AC007868, AC003080, AC005527, AC005881, AL035405, AC003684, AL080316, AL008582, AC007842, Z82179, AL121603, AL023575, D84394, AL035587, AC007546, AL023879, U91319, AC005695, Z85986, AC005618, AL023584, AC005790, AC000134, AC005200, AC004752, AC007664, AC005288, D87675, AC005327, AC006064, AC008273, AC005029, AF207550, Z94801, AC002404, AC007686, AL031595, AC008127, AC018633, Z70280, AC007421, AC006547, Z47046, Z83820, AC020663, Z85987, AC003041, AC002054, AL031575, AC005229, AC005829, Y18000, AC005519, AL022328, AC007563, Z93930, AC007201, AC006468, AC005342, AL050306, AC009516, Y14768, AL133399, AP000501, AC004386, Z83826, AC005952, AC004517, AC002551, AC006539, AF157623, AL031668, AL035423, AP000122, AC005597, AC006115, and AL078587. HPMHD71 870 760426 1-147 15-161 HPMJC01 871 914759 1-254 15-268 AC005484. HPMJC05 872 930844 1-356 15-370 AC006977. HPMJD88 873 930806 1-637 15-651 HPMJE84 874 867587 1-411 15-425 AL035091. HPMJF76 875 965642 1-346 15-360 AC005946, AL049740, AL022157, Z82211, U95626, Z83843, AC003029, and AL133162. HPMJI81 876 930873 1-310 15-324 AA745410, AI469172, AA341228, AW167267, AA605274, AI471543, AW173651, AJ672135, AA370185, AW236342, AI284640, F37169, AI908628, AA630362, AW265393, W07122, AI281881, AI287651, AF150152, AI299050, AI648558, AA515435, AW008317, AW440976, AA100372, AA441788, C16409, AW270270, AI653905, AW162489, AI148277, AI279165, T06828, AI133164, AL120687, AA654771, AA348311, AA626404, AI802526, AA614069, F36273, AI471481, AW080120, AA204655, AI291124, AW419262, AA350859, AI291268, AI537030, AI499094, AT610159, F32894, AA747472, AA338522, AA827981, AI493217, AI446464, F18638, F03097, AW148792, AW151727, AL138265, T07324, AA515905, AA318822, AL041368, AA558015, AA381147, AA578481, H88666, T09071, AA284179, AL038474, AA604897, AI312149, AW021583, AW303876, AA346454, AI889923, AI168185, AI623898, T17016, AA569468, AI583594, AA071144, AA309841, AW410400, AI971377, AI871722, AA434484, AI679706, T07287, AA601876, AW072923, AI358812, AI205084, AA071393, AI679132, AA528516, AA569187, AI754658, AI754336, AC004603, AC005392, AC005947, AC005337, AC005204, AC005772, AF111170, M87919, AC006965, AC008079, AL021332, AC002395, AF001549, U80017, AC003007, AC007684, AC008124, AC002528, AC005874, AF134471, AC005212, AC008055, AL121655, Z95124, AJ246003, AP000120, AP000167, AP000052, AL035079, AC007298, AJ010770, AC002565, AL109985, Z86064, AC004990, AC005829, AC008372, AC004013, AP000477, AC004542, AC007792, AC002045, AL096701, AC006019, AL031675, AP000065, AL033397, AL078593, AC006026, AL049851, AC005211, AL008636, AC005695, AC005356, AC006076, AC004633, AC003982, Z98200, AL008735, AC005251, AC007376, AC004690, AC004668, D84394, AC005037, AC012599, AF217403, AL079306, AC003663, AC005993, A0004986, AC007462, AC005821, AF152365, Z97054, AC007076, AC005915, AL133246, AC005341, AL109758, AL033544, AC003689, AL031053, AC006312, AC007676, U14702, AL133312, AF077058, AC005041, AC002310, AL049836, AC005541, AL049760, AC005226, U11309, AL022302, AL121654, AL080241, AL049745, AC004381, AL031391, AC004605, AL022238, AC007690, U63721, AC002543, AC007225, AC006406, AC006048, AL023284, AC006030, AL109842, AC002375, Z97635, X54175, AC005548, AC006961, AL121658, AC016027, AL136504, AC016830, AF165147, AC010206, AL035090, Z99129, AC005786, AP000244, AC004217, AC005229, AC004534, AL122003, AL133245, AC005486, AC006254, AL035073, X75335, AL049699, AC004263, S70694, AC002426, AF008191, AC008989, AL031296, AL031734, AC006270, AC005754, AC004988, AC007221, AF111168, Z84490, AC005763, AL023880, AC005255, AC005747, AL031662, U92032, Z84489, AC007285, AC002472, AC007664, AL034417, AL133244, AC005696, AC008498, AC008040, AC005385, AL031283, AL049736, AC002457, AC002049, AC005151, AP000123, AP0G0055, AP000170, AC004070, AC006387, Z82216, AL008720, AL132641, Z97198, Z95326, AF178030, AC007312, AF172277, AC006484, AC004810, Z84488, AL031542, AF119358, AC006044, AL117330, AL022320, AC005565, AC003119, AL031388, AC007666, AC006255, AL031678, AL035249, AC007632, AL121767, AL031176, Z68870, AC004754, Z99496, AC005912, AC009263, AC005744, AC008282, AC011718, Z69666, AL022726, AC005740, AC005602, AC006362, AC002429, AB023052, AC004099, AC003664, AC007514, AF134726, AC000070, AC000086, AC005789, AP000509, and AC005231. HPMIN59 877 946876 1-547 15-561 AA278625, AL043338, AA417787, AI917735, AW303607, AI819365, W23045, AI243857, AA157110, and AA278626. HPMJ046 878 922649 1-293 15-307 HPMJR02 879 917419 1-505 15-519 AC005406. HPMJV08 880 958001 1-430 15-444 HPMJY55 881 922657 1-423 15-437 AC006443. HPMKB19 882 969478 1-837 15-851 H66737, AA610385, AI825101, and AC006453. HPMKI53 883 957997 1-200 15-214 HPMKM81 884 894416 1-880 15-894 AW130066, AI826186, AW150146, AA129308, AW392049, AA129351, AA453884, AI278397, N24006, AA453799, AI796331, AA336728, N74882, AW380924, AA369050, AI868063, AW131507, AC004774, D31734, AF033011, U67840, L24443, AF022075, AF022077, AF022076, U25274, AF096161, L09729, U03876, Z63754, and Z63755. HPMKN43 885 867573 1-626 15-640 AA457012, and AC002310. HPMLE04 886 867533 1-562 15-576 N89001. HPMLK02 887 918123 1-497 15-511 AA848128, and Z93244. HPMLK76 888 922621 1-477 15-491 HPMLL74 889 953069 1-493 15-507 R66945, and AI090443. HPMLW10 890 963037 1-330 15-344 Z71183. HPM5F86 891 509490 1-323 15-337 HPRAE13 892 971652 1-461 15-475 AI097067, AI383144, AA370038, and AC005746. HPRAN84 893 585489 1-315 15-329 AA370352, AA370860, AA024451, AL118518, AC007016, AF064859, AC004707, Z84718, and AP000351. HPRAU45 894 536630 1-214 15-228 AA370859, AA370351, AC002536, and AL034371. HPRAZ10 895 968692 1-452 15-466 AA398734, AA393413, and AA371065. HPRBA65 896 655537 1-228 15-242 AA371132, AA371091, AW270853, AI978920, AI468384, AI971306, AA361429, and AC005156. HPRBE36 897 655587 1-318 15-332 AA371242, AA757085, and AI018367. HPRBL91 898 655693 1-286 15-300 AA370885, and AC002366. HPRCB11 899 960316 1-338 15-352 HPRCB21 900 655725 1-306 15-320 AC007198. HPRCC08 901 939490 1-284 15-298 AA298484. HPRCC61 902 964909 1-321 15-335 AA370278. HPRCN41 903 655554 1-343 15-357 HPRCU13 904 968521 1-265 15-279 AC002352. HPR5B16 905 666295 1-258 15-272 HPRTL26 906 849081 1-405 15-419 AA370571, and AI905054. HPRTP73 907 708761 1-292 15-306 AA369901. HPVAB11 908 967944 1-567 15-581 AI925663, AA458636, AA193435, AA252059, W94787, AI470629, AW016321, and AA193532. HPVAF49 909 655578 1-412 15-426 HPVAF69 910 753744 1-415 15-429 AI584019, and R79760. HPVAH36 911 525537 1-479 15-493 AA296794. HPWAF85 912 655691 1-606 15-620 U18010, AI699466, and L77587. HPWAH48 913 655527 1-143 15-157 HPWA577 914 908450 1-725 15-739 AW139964, W81697, AW088477, AI887846, AA447817, AA447667, AA677404, R93353, AA831618, AA574189, AI124782, AA584550, AA055366, F13631, AA765804, AW268271, AA993918, AA679335, AC008173, AC004074, AF146367, AF124523, AF118808, AL096775, AL109954, Z83841, AC002464, AC005820, AC006048, AP000509, D84394, AC007359, AC008175, AC006499, AL136130, AL096801, and W81696. HPWBA33 915 655733 1-213 15-227 HPWB084 916 867289 1-330 15-344 T65635, AI354862, AA017323, H48816, AI187056, AA829490, AA507745, T47324, AA548692, H91844, AA565232, AA640022, T05163, N22395, AA524604, AA524829, AA373304, AI818505, Z83844, AL031255, AC012384, AC004408, AC006449, AC002996, AC004149, M89651, AC005529, AC004491, AL031228, AC002357, AC002425, AC004531, AC004947, AC005837, AC004051, AL049779, U52112, AL132774, AC004690, AC005225, AC006162, AC007686, Z69303, AC006006, AC004231, AC005323, AL136295, AC002511, AF107045, AC006077, AC004596, AL050317, AL022324, AC006275, AL080245, AL035427, AL031053, AL049776, AL024507, AC005399, AC004682, AP000688, AC002375, AL078476, AL121825, AC004552, AC005839, AC007052, AC005527, AL049829, AC007055, AC003049, AP000555, and AF124730. HPWCA53 917 657484 1-354 15-368 AI075673, and AC008015. HPWCJ27 918 655614 1-344 15-358 HPWCJ67 919 655560 1-367 15-381 HPWCJ82 920 655577 1-472 15-486 T20053. HPWDA73 921 514113 1-643 15-657 AW338702. HPWDA86 922 961529 1-240 15-254 AW080827, AI535841, AC002038, AC002041, and AC006352. HPWDD72 923 537333 1-528 15-542 H68009, AA532955, and AC005189. HPWSB35 924 655713 1-329 15-343 HPZAB38 925 655591 1-241 15-255 HSWAC73 926 710354 1-396 15-410 AA300733, AW070249, and AC000089, HSWAD39 927 705322 1-785 15-799 AW264269, AW028491, AA424983, AA418896, AA418895, AA460211, AI800304, AI685341, AI188340, AI160534, N26011, AW057810, and AI917673. HSWBD86 928 785439 1-138 15-152 R59356, F10756, AA480322, AI768068, T15624, AI760446, AI870727, AA534696, AA679825, AI868057, AI274320, AA716748, AI922465, and AA907744. HSWBJ40 929 711066 1-613 15-627 AI610767, AA128537, AA045673, H26372, AI564965, C00296, H27484, AA045672, and AF153882. HSWB034 930 868007 1-839 15-853 AI264314, AI656489, AA608739, AL040264, C15165, AI922383, AA644468, AI391663, AI285883, AI538754, AI696671, AA578673, AI587042, AA843485, R27828, AI927062, AA888452, AI379567, AI093793, AA502801, H95376, AI696130, AA032171, AI697448, AA032170, N66388, AI948739, AI499520, and D60629. HTEAA54 693 923070 1-694 15-708 AA382253, AI806382, and AI478870. HTEAB52 932 537136 1-582 15-596 AA382333, AA382331, H52860, and AL040167, HTEAD32 933 504353 1-362 15-376 AA382382, AA382236, and AC006305. HTEAD95 934 961232 1-451 15-465 AA382376, AA382242, AA860376, and AC006445. HTEAF07 935 835805 1-312 15-326 AA382453. HTEAF26 936 537271 1-301 15-315 H53354, AA758164, AA448168, AI025042, AI829657, AA382854, AA382293, AA400727, AA442764, and AA812451. HTEAG50 937 787500 1-297 15-311 AA382498. HTEAK57 938 536769 1-411 15-425 H09661, AW196402, AA760720, AA432259, AI539284, AI805310, AA781214, AW268890, AI797250, AW235912, AA993321, AI017538, AW274549, AA884002, AI017535, AI217337, AW014623, AA868679, AI808721, AI769073, N62418, AI364253, AA909554, AA382799, AI917688, AA485055, AL080136, and AF079363. HTEAL28 939 963538 1-666 15-680 AA429726, AA398189, H53400, AA382855, AA382294, AA383397, AA382295, AA382880, and Z58143. HTEAP91 940 966113 1-746 15-760 AA411883, AW444833, AA382955, AA889519, AI217183, and AA781849. HTEAR84 941 783328 1-237 15-251 AA382996, AA180840, AI929073, AL133353, AF132966, and X66366. HTEAV43 942 927010 1-583 15-597 AA770016, AW195558, AA757200, AW340425, AW182241, AA383009, and AI191751. HTEAY67 943 679390 1-433 15-447 AA383288, AL044302, AA398247, AI916926, AI970265, AA399313, AI806241, AI208574, AA994365, AA382290, and AL137385. HTEAZ54 944 793441 1-499 15-513 AA383257, AA812455, and AL137538. HTEBC74 945 887782 1-308 15-322 AA383466. HTEBD35 946 967959 1-303 15-317 AA383417, and AA383322. HTEBD40 947 779134 1-457 15-471 AA383323, AI950478, and AL121757. HTEBJ78 948 779265 1-1003 15-1017 AA383746, AF012361, AI918814, AI638690, and AF088868. HTEBP39 949 742218 1-577 15-591 AL040588, and AW386895. HTEB530 950 693377 1-326 15-340 HTEB577 951 953904 1-592 15-606 AA102609, AA903522, AA810166, AI887877, AA928872, AI912645, AI628759, AI652056, AA372813, AA326308, AA313595, AA252658, AA491058, AA205648, AW375850, AA252657, and AA082983. HTEBS80 952 854052 1-381 15-395 AA399558. HTEBX62 953 508150 1-404 15-418 AL133028, and AB033037. HTEBY08 954 960427 1-344 15-358 M78063, AI560292, H50301, AA340759, AA340760, H45375, U09355, and AF096153. HTEBY15 955 526281 1-252 15-266 HTEBY28 956 923026 1-609 15-623 AB033083. HTEBY41 957 711523 1-230 15-244 HTEBY61 958 967340 1-421 15-435 AA725713, AL040570, R48431, and AC020663. HTEBZ21 959 958381 1-340 15-354 AF193806. HTECA13 960 507053 1-393 15-407 AA382976. HTECA16 961 764416 1-482 15-496 AI017997. HTECA21 962 911369 1-688 15-702 R20356, H09898, and R13239. HTECA32 963 947605 1-779 15-793 HTECA51 964 708860 1-414 15-428 AI479803, R89200, AA382300, AA700729, and AL035450. HTECA83 965 870692 1-446 15-460 HTECB21 966 921070 1-359 15-373 HTECC13 967 971673 1-301 15-315 HTECC20 968 963353 1-993 15-1007 AI521186, AI287890, AW006015, AI739342, AI536021, AI915154, D59412, AI382968, AA723799, C14160, and R58305. HTECC37 969 508143 1-317 15-331 HTECC38 970 844558 1-553 15-567 AL042436, AI125824, AA437087, AI028669, AI024321, AW241753, AA400083, AA953011, AA972296, AJ674705, and AL042437. HTECC66 971 790937 1-409 15-423 AW375961, H12646, N46186, A1114644, AA133382, AA314626, T92864, AA482645, AA203566, W20194, AA878228, W80608, AA699466, AA482495, Z25122, AA490161, AA939181, AI635552, and AF113691. HTBCC80 972 796820 1-446 15-460 AL079435, AW070333, AA868621, AI024608, AI208541, AA644440, AA992264, AI219709, and AL078621. HTECC85 973 508138 1-337 15-351 AA219332, and AW274715. HTECC96 974 959874 1-547 15-561 AL039822. HTECD17 975 508108 1-397 15-411 Z68165. HTECD18 976 973163 1-614 15-628 T36107, T19204, AF012359, and T36109. HTBCD36 977 518124 1-421 15-435 AL079683, T69495, AA377984, AA411067, W19966, AL135463, AA152011, AI080369, AI928496, AI969686, AW150086, AW162108, AW245409, AW245596, AW087350, AI660688, AW025370, AI986318, AA417624, AW073180, R65681, AA609692, AI568566, AF015913, and AF167572. HTECD62 978 527207 1-242 15-256 AI018016, AA927826, AA781742, AI206323, and AI699610. HTECD75 979 727422 1-410 15-424 AA770236. HTECE09 980 620494 1-363 15-377 AA074745, AA311579, AW369123, AW377808, AW369199, AA305128, AA279742, AA382491, AA457232, AA350374, and AF119664. HTECE44 981 764830 1-349 15-363 AI016755, AA626104, AI215071, AI968379, AA506126, AI340264, AI214879, AI653073, AI208052, AW235456, and AA609852. HTECE45 982 790894 1-349 15-363 AA702149, AI760177, W87526, AL042666, AA721639, AA721643, and R55626. HTECE69 983 522983 1-340 15-354 AA209512, and AF084521. HTECE91 984 522984 1-283 15-297 HTEDF13 985 522964 1-370 15-384 HTEDF23 986 522966 1-319 15-333 HTEDF57 987 964734 1-467 15-481 AA206531, AA205273, AF134584, AF133655, R57172, AA370673, AL049834, AF144487, and AF144488. HTEDF76 988 522973 1-371 15-385 HTEDG16 989 925527 1-1246 15-1260 AI341284, AA954970, AA971333, AI656306, AI341232, AI962769, AI970130, AI015246, AI149570, AW236864, AI187784, AI824998, AI699532, AW087767, AA776716, AA758202, H75549, AI282907, and AC003691. HTEDG34 990 761752 1-601 15-615 A65985. HTEDH21 991 522764 1-307 15-321 AW237166, and AI806759. HTEDH22 992 522765 1-412 15-426 AA884595, AI004070, AI652358, AI933335, and AC006012. HTEDH54 993 957762 1-398 15-412 AI142272, AW303480, and AL117355. HTEDI02 994 921243 1-693 15-707 AW166305. HTEDI16 995 932292 1-830 15-844 AI200759, N35603, and AI806635. HTEDI82 996 536477 1-536 15-550 HTEDJ04 997 519940 1-151 15-165 HTEDJ30 998 771404 1-576 15-590 AA938733, AI830416, H99099, AI768985, AA410878, AA969071, AI220012, AI568973, AI354321, AW130634, AI219538, AI280159, AI751123, AI693274, and Z61810. HTEDM08 999 960303 1-243 15-257 AA383292, and AA010475. HTED031 1000 870711 1-279 15-293 HTED051 1001 530592 1-336 15-350 HTED059 1002 964379 1-277 15-291 AL050310. HTEDP15 1003 870675 1-309 15-323 AC008119. HTEDP31 1004 870548 1-526 15-540 AC004674. HTEDP32 1005 839532 1-412 15-426 HTEDP83 1006 536821 1-391 15-405 AA382559. HTEDQ30 1007 530589 1-192 15-206 AA470110. HTEDQ72 1008 795332 1-463 15-477 AA424209. HTEDQ83 1009 530586 1-493 15-507 HTEDR71 1010 761585 1-303 15-317 AI003479, AJ003512, AJ003478, AJ239328, and AP000219. HTEDR91 1011 530451 1-363 15-377 AA778548. HTEDU45 1012 870708 1-1168 15-1182 AA401417, AI654822, AA131789, AA401393, AA040136, AA030057, AA040089, AW002428, AA131796, AI809387, AI208853, AI798677, AI808134, AA028977, AA131846, and AI468240. HTEDU48 1013 932315 1-718 15-732 HTEDV02 1014 921114 1-152 15-166 HTEDX22 1015 523959 1-552 15-566 T64832, Z45475, and F12119. HTEDX55 1016 530452 1-345 15-359 AL035450. HTEDY38 1017 771505 1-128 15-142 HTEDY54 1018 922964 1-845 15-859 AI141062, AA779725, AA451707, AA453324, and AA954529. HTEDY57 1019 530580 1-314 15-328 HTEEA03 1020 925399 1-227 15-241 HTEEB18 1021 523962 1-537 15-551 AA995142, AC005661, and Z65242. HTEEB33 1022 924818 1-601 15-615 AL049780, and AC007055. HTEEC10 1023 963517 1-353 15-367 HTEEE65 1024 530157 1-372 15-386 AI243357, AI126440, AI693753, and AA783013. HTEEF31 1025 924840 1-333 15-347 HTEEH31 1026 507814 1-279 15-293 HTEEU23 1027 524059 1-314 15-328 AL040261, AI525252, and AI025700. HTEEU52 1028 530199 1-331 15-345 HTEEU88 1029 698315 1-355 15-369 AA383576, T04917, T35202, AI422683, AI694269, AW341450, AW172298, AI253197, AI392973, AI817020, AI675030, AW149563, AI830691, AI288333, AI420397, AI768573, AW300444, AW271819, AI862664, AW165982, AI761400, AI826256, AI368689, AI697857, AI889625, AI972408, AI357436, AI421517, AI651095, AI283759, AI634398, AI523543 AI948511, AW196914, AI992087, AI417903, AI827278, AI927043, AW237591, AI831948, AI831197, AI830712, AW085599, AI375540, AI300150, AI936396, AI082343, AI190058, AI369782, AA937125, AI926819, AA872799, AI831516, AA502373, AI823952, AI262912, and AL035461. HTEEU92 1030 960127 1-471 15-485 AI005426. HTEEV53 1031 523957 1-298 15-312 HTEEW73 1032 917206 1-862 15-876 AI125404, AI247364, AI208217, AA910021, AI915307, and T11495. HTEEZ95 1033 530095 1-134 15-148 HTEFJ53 1034 935982 1-210 15-224 HTEFM31 1035 771355 1-449 15-463 AL137385. HTEFN15 1036 959854 1-480 15-494 HTEFO32 1037 529272 1-137 15-151 HTEFO76 1038 770270 1-404 15-418 HTEFP14 1039 659369 1-289 15-303 AL080239, and AL030997. HTEFP50 1040 507219 1-398 15-412 AI733211, AA977235, and AI793144. HTBFP61 1041 711399 1-339 15-353 HTEF560 1042 836010 1-308 15-322 Z84469. HTEFU46 1043 920604 1-182 15-196 HTEFW55 1044 787550 1-720 15-734 Z20330. HTEFW56 1045 528019 1-344 15-358 HTEFW78 1046 961061 1-327 15-341 AA416708. HTEFX53 1047 842047 1-301 15-315 HTEGA13 1048 656077 1-260 15-274 AA304950, and AC005237. HTEGA17 1049 964198 1-1718 15-1732 AA861754, AI041049, AA974148, AI025824, AI015271, AA973722, AI262750, AF012394, H44966, H45019, H65081, H65127, H65128, H65081, N30790, N32825, N41565, AA021000, AA037708, AA158991, AA158990, AA552704, AA581540, AA583387, AA594383, AA568601, AA639650, AA962753, AI076864, C01177, C17452, AA610069, AA677739, AA678002, Z17891, Z17844, Z17858, D29489, D31204, D31401, D31430, AI147272, AI348141, AI434148, AI446782, AI401705, AI473505, AI475244, AI560742, AJ565331, AI479120, AI567547, AI569204, AI570723, AI571642, AI521092, AI587097, AI619824, AI619826, AI683822, AI745345, AI700348, AI862997, AI891040, AI805378, AI805561, AI814808, AI917522, AI924990, AI925791, AI925824, AI926709, AI932677, AW008971, AW025107, AW028354, AW028895, and AW044371. HTEGA43 1050 715583 1-293 15-307 HTEGA47 1051 503300 1-305 15-319 AA469976, and AA382993. HTEGD11 1052 967698 1-454 15-468 AI739081. HTEGE44 1053 528017 1-460 15-474 HTBGF78 1054 614242 1-394 15-408 AA320491, AA461257, T96959, AA620998, AI803092, AI598264, AI802911, AA613500, AI701066, AA873354, AA976002, AI337726, AI401363, AA889162, AW449691, AA460950, AI435494, T91835, N47591, T08650, AI672896, AI015106, AL122076, AF082179, AF173643, and AF088884. HTEGF95 1055 796660 1-264 15-278 AI809182, and AI014526. HTEGG07 1056 954115 1-450 15-464 HTEGG61 1057 528007 1-203 15-217 HTEGK51 1058 520046 1-137 15-151 HTEGM38 1059 675087 1-350 15-364 AA496105, AL038451, AA020916, AA214222, AL038833, AW239553, AL038903, AL036026, W94506, H11258, H19187, T09424, AW163336, AA084982, AA853848, AA852612, AA134785, T30709, T31235, R13838, T30596, T31277, T32509, F08351, T30996, R61645, AI002404, AA281162, N33973, W63690, AA056138, AA400554, AA224046, AW160678, AA252722, AA308905, H37946, AA159207, AA337592, H15180, N36548, T78050, AI214139, H45908, AL036764, AL038918, AA486190, N99529, AA176166, T29922, AA173378, AI929392, AA993699, T32147, W92551, AA314753, W20343, AI028519, W52361, R12459, R17656, D30841, D56168, AA018894, AW375983, AA318870, R57052, AA083038, AA018506, AA401854, W94711, H82178, AB014888, AB015799, AF075601, AF060703, AB015798, AF080569, AB028854, and AF035962. HTEGN63 1060 520037 1-196 15-210 AB007131, AP001052, and AP001051. HTEGO05 1061 932583 1-1086 15-1100 AA059465, AA059211, AA731209, AA236961, T86500, T87461, AL024498, and M35862. HTEGQ21 1062 923059 1-419 15-433 AA382826,AA382492,AI917341, AI967930, AI990328, AI041198, AW135194, AI936466, AI990195, AI336861, AI825657, AA609860, AI652939, AI950262, and AI968690. HTEGQ74 1063 573865 1-358 15-372 HTEGR56 1064 959871 1-186 15-200 HTEGR88 1065 871611 1-405 15-419 AL133660. HTEG516 1066 527914 1-340 15-354 HTEG534 1067 458520 1-391 15-405 D80168, D59627, C14298, D51079, D59695, D52291, D80949, AW360780, D59503, D51213, C14227, D80290, C14389, AW377669, AW352172, T11417, D80258, D80064, D58246, D59889, D52059, D45273, D80014, D80391, AW377661, D59787, D80196, D57483, T03048, C16955, AI557751, D59484, AI535686, Z33452, C06015, AI557774, T02974, C04682, AA514184, H67854, H67866, AI525216, AI525228, D51053, AI535961, D80251, N66429, AI525969, AI525238, AI525222, AI525227, AB010386, AR016808, U37689, I81198, X64588, I82446, AB019242, and A47134, HTEGS93 1068 506653 1-395 15-409 HTEGT29 1069 870638 1-463 15-477 AA610046, AA725767, AA609763, AA694482, AI674115, and AI222344. HTEGT33 1070 716783 1-505 15-519 AA459933, and AA460208. HTEGU13 1071 520041 1-380 15-394 AA725598, AA437008, AA758847, and AA383617. HTEGU32 1072 524053 1-492 15-506 AI208922, AF012358, AC000359, AF176024, and AC000357, HTEGU62 1073 573885 1-307 15-321 HTEGU93 1074 764831 1-721 15-735 AL037365, AI968379, AA397716, AI016755, AI340264, AA626104, AA435927, AA506126, and AL133624. HTEGV08 1075 959888 1-425 15-439 AP000275, AP000105, AP000037, and AC002452. HTEGV60 1076 822954 1-484 15-498 AA210913. HTEGV84 1077 870240 1-759 15-773 AI809518, AA725632, AA400546, AW303510, AA621301, AA400438, AI184200, AI016652, AI698674, AA758091, AA757258, AA725799, and AA705799. HTEGW41 1078 573880 1-406 15-420 AF169385, and AF149310. HTEGW94 1079 794350 1-526 15-540 HTEGX74 1080 783829 1-544 15-558 AA789286, AI339366, AI656082, AA861573, AA416690, AI808240, AA889130, and AI216654. HTEGY01 1081 917214 1-438 15-452 HTEGY85 1082 573849 1-300 15-314 AL080197, AP000346, and AL022324. HTEHB07 1083 870707 1-336 15-350 AA383326, and AI672505, HTEHC20 1084 526704 1-313 15-327 Z98752. HTEHC47 1085 973071 1-723 15-737 AA436088, AI149899, AI002083, AA411806, AA470059, AA781801, AA416972, AA435988, AA758635, and AA707529. HTEHC60 1086 965998 1-610 15-624 HTEHC78 1087 573882 1-332 15-346 HTEHE60 1088 795264 1-551 15-565 AI018790, AA885492, AI377750, AW340453, and AC007114. HTEHE67 1089 784926 1-677 15-691 AA421403, AA411967, AA412565, AI825585, AW136990, AI962705, AI825455, and AA889516. HTEHE78 1090 932312 1-357 15-371 AA642104, AA664126, N66948, AI753334, N70325, AA601713, AA320178, H53040, AA577770, H53039, AA515742, AI222360, AA837716, AL109628, AC006064, AL022721, AP001052, AC004694, AL109801, AL117258, AL109759, AC004884, AC005476, Z95116, AL022159, AC005015, AC003101, AL035086, Z99943, U91323, U91318, AC007773, AC005261, AC002350, AL031289, AC005081, AC005529, U73640, AC005552, AC007040, AL133244, AC006163, AC007285, AC007057, AL121655, AC006324, AR036572, AP000092, AC005829, AL132777, AP000512, AC000025, AF107257, AC005520, AF107258, AP000236, AC004814, AC006581, AC010168, AC005790, AL049759, AC005519, AL022316, AC004100, AL031427, AC007688, AL031584, AC009516, AC006449, AC006441, AC005387, AP000501, AL121652, AP000510, AL049539, U91321, AC003071, AC004908, AC005921, AD001527, AC005800, Z92542, AL034548, AF196969, AC004552, AC009181, AC005971, AC004966, AC004815, AL031681, AC007617, AF196779, AC004707, AB023050, Z83844, AC002312, Z82190, AC007172, AC004990, AC002565, AC007386, AF134726, AL034549, Z82208, Z95329, AC005037, AC007637, AC005162, AL031680, AL022165, AF026069, Z97184, AC006966, and AC003086. HTEHE91 1091 790342 1-520 15-534 AI653740, AI223017, AA393574, AP000346, AL022324, and AL080197 HTEHF13 1092 667224 1-319 15-333 HTEHF66 1093 836999 1-424 15-438 AL137678, and AL109657. HTEHG44 1094 933624 1-682 15-696 AA446074, AJ224924, and AA868166. HTEHJ06 1095 935984 1-817 15-831 AA394226, AA398139, AA025620, AA451812, AA454022, and AC012599. HTEHI14 1096 526687 1-444 15-458 HTEHJ54 1097 533960 1-338 15-352 R19058, Z44007, F06961, and F05366. HTEHJ62 1098 922559 1-390 15-404 AI202243, AA687318, and AI184808. HTEHI93 1099 870629 1-317 15-331 HTEHJ64 1100 530749 1-235 15-249 HTEHK40 1101 660875 1-317 15-331 HTEHK70 1102 771432 1-430 15-444 HTEHK81 1103 573866 1-414 15-428 HTEHL96 1104 573859 1-390 15-404 AA926746. HTEHO56 1105 787521 1-664 15-678 AL042716, AI634081, AI656008, AI383457, AA298264, AW274940, AW183456, AI824911, H48934, and AI015007. HTEHP02 1106 920625 1-429 15-443 HTEHP20 1107 967443 1-379 15-393 AA393345, AI018421, AI018412, and AI621296. HTEHP50 1108 531505 1-219 15-233 HTEHP60 1109 573853 1-439 15-453 HTEHP67 1110 751866 1-425 15-439 AA429653, and AL137385. HTEHP80 1111 573830 1-354 15-368 AL042482. HTEHR83 1112 573841 1-260 15-274 AW117582, and AW275130, HTEH519 1113 529280 1-324 15-338 HTEHU20 1114 573813 1-345 15-359 AA625735, and AI205755. HTEHU68 1115 786378 1-362 15-376 AI808748, and AA868749. HTEHU73 1116 870083 1-377 15-391 HTEHV72 1117 920610 1-356 15-370 AA449587, Z62660, and Z62661. HTEHV86 1118 785652 1-454 15-468 AB007926. HTEHW03 1119 924832 1-439 15-453 HTEHW21 1120 760552 1-286 15-300 H99838, AL037447, H98172, R99332, and N73909. HTEHX03 1121 924826 1-502 15-516 AI198906, AI743542, AI807563, AI392615, AI813744, AI150517, and AI150519. HTEHX32 1122 772643 1-440 15-454 AI699984, AA470157, AI018717, AI917728, AA398746, AA393334, AI216704, AA868127, and AL049742. HTEHX51 1123 668553 1-200 15-214 AC004148. HTEHX92 1124 527167 1-477 15-491 HTEIA60 1125 859130 1-442 15-456 AA594897, Z46029, AA316462, T27008, AA306099, F12789, R05542, AA635902, T75086, T35592, AW378962, R28411, AA740171, T52620, AL021707, and AJ236698. HTEIA80 1126 721831 1-265 15-279 HTEIB14 1127 963099 1-700 15-714 AI126171, AW172978, AI802445, AI811298, AI807074, AI635206, W96514, AI624106, AI190433, AI810701, AL043767, H43143, AI271523, AI911113, AA644026, AI803788, AI566934, AI187824, AA043579, AI869010, AI015017, and R55050. HTEIF40 1128 958355 1-578 15-592 AI806847, AA431560, AI219847, AA913948, AI633873, AI638029, AW003193, AI990760, AA861291, AI190550, and AI187284. HTEIF68 1129 573828 1-263 15-277 HTEJG32 1130 699470 1-313 15-327 AA383150. HTEIH70 1131 573826 1-186 15-200 HTEJJ17 1132 520113 1-425 15-439 AF088868. HTEIJ41 1133 712520 1-347 15-361 AA037622, AA151557, AA884833, and AI027960. HTEIJ73 1134 958241 1-322 15-336 HTEJJ77 1135 772402 1-55 15-69 HTEIK11 1136 967431 1-465 15-479 AA370836. HTEIK70 1137 530454 1-107 15-121 HTEIK90 1138 789121 1-383 15-397 AL133625, and AL050310. HTEIL07 1139 953803 1-445 15-459 H55431, and AL031843. HTEIL48 1140 523681 1-302 15-316 HTEIL70 1141 520045 1-515 15-529 AA383469, and AW340027. HTEIL71 1142 760551 1-418 15-432 AW374031, AI376865, AA610337, AL031277, AC004159, AL035073, Z83838, AC011422, and AL031286. HTEIN68 1143 753210 1-333 15-347 HTEIN95 1144 839884 1-602 15-616 AI638483. HTEIO02 1145 920622 1-365 15-379 AW188204, and AL078587. HTEJO12 1146 653244 1-322 15-336 HTEIO28 1147 573803 1-344 15-358 HTEIP88 1148 941155 1-253 15-267 HTEIP92 1149 523892 1-356 15-370 HTEIQ74 1150 765794 1-576 15-590 AA905565. HTEIR33 1151 928058 1-504 15-518 AI041198, AW135194, AI336861, AI917341, AI825657, AI936466, AI967930, AI990195, AI990328, AA609860, AI652939, AI950262, AI968690, AW043968, AI695938, AI918858, AI207159, AI961172, AI635425, AA382492, AA382826, and Z54930. HTEIS65 1152 573775 1-444 15-458 HTEIU75 1153 779163 1-535 15-549 HTEIU92 1154 870652 1-390 15-404 HTEIV54 1155 922027 1-859 15-873 AA608560, AW119083, AI805320, AW241508, AA478132, AI935179, AA478131, AW241453, AI148017, AA496125, AI159761, AI290727, AA757496, AI039534, AA410246, AW015244, AA991785, AI299213, AI191790, F32781, H53433, AA708313, AA757725, AA987362, AI018579, AI824880, AI989666, AI950419, H53434, AI703120, AA436358, AA410593, AA410594, AI205656, AA404329, AA404331, AI147261, AA935676, AA708988, and AF163095. HTBIV86 1156 784657 1-476 15-490 AA884237, and Z66028. HTEIW27 1157 829698 1-790 15-804 AL040266, AA045127, H71355, AA070703, AA036715, AA325559, AA043642, AA196645, H94227, AA305440, AA383234, H61672, H06121, R60099, AL042836, AI016643, AW410572, AL042837, and AJ018804. HTEJW37 1158 573891 1-340 15-354 HTEJX28 1159 836011 1-725 15-739 AA878363, AL040461, AI806762, AL040944, N48708, AA961620, AI015474, AI122718, AI674958, AI925550, AA316256, AA846418, AI270517, AA383573, AW087494, Z40157, AA915976, AA927218, AA912892, AI216366, D20536, AL109748, and AL078614. HTEJX85 1160 864251 1-364 15-378 AI143096, AA476476, AF112968, and AF133914. HTEIY52 1161 963536 1-365 15-379 HTEJY69 1162 577783 1-342 15-356 AA860220, AA373213, AA095300,AA294896, AA056395, AW369291, AA081316, AA081068, AA258633, AA491648, T78543, AI565548, T68394, D81309, AA303509, C02623, AA552624, C15625, W65448, and H56519. HTETY80 1163 955242 1-640 15-654 AI206714, AI962380, AW139167, AI341507, AW197295, AF146793, and AC004673. HTEIZ76 1164 523764 1-373 15-387 HTEJB20 1165 528015 1-336 15-350 AW119138, AA508616, and AC000386. HTEJB25 1166 530590 1-364 15-378 AI804160, AI287878, AA400787, AI003207, AF176315, AF042089, AC007040, AC000385, and AC004967. HTEJB81 1167 870644 1-326 15-340 AC005230, andAL031230. HTEJC28 1168 573774 1-292 15-306 HTEJC95 1169 772989 1-412 15-426 HTEJE15 1170 908360 1-577 15-591 AI217144, AA399611, AA398976, AI025074, AA758412, AW449170, AI953070, AI337133, AI654417, AA608877, AI969018, AA400066, AA401568, AL137462, and 575275. HTEJE50 1171 520049 1-410 15-424 AA383469. HTEJF45 1172 942476 1-704 15-718 AA927155, AI989936, AI870479, AW196902, and AW137017. HTEJG24 1173 526278 1-432 15-446 HTEJJ43 1174 774243 1-505 15-519 HTEJL21 1175 573742 1-460 15-474 AA913820, AW138390, W37338, AI139797, AW135343, AA776708, AA621016, AW274952, AI623224, AI125250, AA778537, AI208106, AI637631, AW341652, AA776715, AI204215, AA609761, AI671266, AI023591, AI950399, AA758819, AW104292, AI188024, AW058598, AA460183, AI969065, W37337, and AA824405, HTEJM56 1176 952255 1-392 15-406 AL042395, AA504349, AI693474, AI125391, AL041671, AW168041, AA838043, AI990015, AI864457, AI149664, AI738586, AL041569, AW294188, AI805280, AA579771, AW273185, AI653680, AW197733, AI138789, AI699335, AI475427, AA883961, AI203057, AI968077, AA383594, AA976749, AI648684, AI952360, AI680162, AI590021, AW076093, AW264516, AI073952, AI568870, AI564719, AI623828, AA808060, AI683684, AI866457, AI628292, AW196868, AW075413, AI590686, AI867042, AI922365, AW081255, AI285586, AI249375, AI610293, AW103878, AI915576, AW403717, AI475455, AI811860, AI282903, AI539808, AI873644, AI174394, AI469811, AI831140, AI872910, AI690585, AI539829, AI863191, AI613270, AI625464, AI281660, AI870187, AI886022, AI269862, AI624293, AI920833, AI680498, AI934259, AI610114, AW193026, AL121270, AI289337, AW075657, AI364788, AI383919, AW168723, AI922901, AI636719, AW073697, AI863321, AI270055, AI633073, AI624543, AI610645, AI702433, AI611743, AI690312, AL039276, AI689420, AL045500, AW080992, AI687065, AI432040, AL048656, AI819326, AW238730, AI445976, AI744256, AA572758, AL045163, AI627880, AI866741, AI805385, AI612721, AL119791, AW079159, AI343059, AI619716, AI828731, AI612759, AW089179, AW151729, AI696819, AI870192, AI567351, AI349933, AI934011, AI280661, AI699011, AI537617, AI919345, AI251830, AW088899, AI366549, AI539153, AW088144, AL036214, AI866608, AI859464, AI866585, AI499986, AW149236, AW083804, AI862144, AW170734, AI696626, AL040241, AI554821, AI589993, AW059713, AI921082, AL038445, AW168425, AI345111, AI446373, AI358701, AL036638, AI537677, AI621179, AI433157, AL041150, AI537837, AI159837, AI874351, AL038882, AI520785, AI609059, AI344817, AI539771, AI798258, AI922577, AI471361, AI500659, AI288285, AI889168, AI344935, AI866573, AW068845, AW103228, AL045620, AI476109, AI815232, AI801325, AI500523, AI573060, AW302965, AA640779, AI345608, AI582932, AI284517, AA613907, AI500706, AI445237, AI491776, AI758613, AW151138, AL042628, AI521560, AI889189, AI500662, AI284509, AI439452, AI857724, AW148320, AI633493, AW169653, AI434256, AI344785, AI249962, AL041772, AI609677, AI888661, AI811344, AI284513, AI620284, AI888118, AI349614, AI872051, AI589273, AI866510, AI569583, AW302992, AI801112, AW088903, AI440252, AI800152, AI963068, AI569632, AI274769, AI348854, AL036664, AW023590, AI608676, AI345471, AW088134, AA579232, AA494167, AW075084, AI468872, AA420722, AI537307, AL120853, AL040243, AI251205, AI924971, AI287489, AI698401, AI524607, AI683714, AL043632, AL043326, AI538342, N71180, AI433976, AC003688, AF096834, AF073955, AF073954, AL117585, S68736, A08916, A08910, AR000496, U39656, A08909, I48978, I89947, A08913, U72620, I89931, I49625, AL049382, AF090896, AL050060, I26207, AL137556, AL137283, AF113676, AL137538, AF104032, AB019565, A93350, X93495, AF158248, AL122093, AL137527, AL050393, AL122121, I48979, AF119337, U35846, AL122123, AL137557, I33392, AJ242859, X84990, E07108, AL050138, AF113689, I03321, AF118070, U00763, AR059958, AF026124, AF090903, AL133568, AL080124, A08912, AL117583, E15569, AL050116, AL050146, AL117435, Y14314, AL049452, U67958, AL122098, AF185576, AL080137, AJ012755, A93016, AF078844, E03348, Y11587, I42402, AL110221, AF125949, AF113013, AL137463, AF081195, AL122110, I09360, AL133093, AL137648, AJ238278, AF017152, AL080127, AL133077, AL050108, AI2297, AL133104, AF113690, AL049466, Y16645, AL050024, AL110196, AJ000937, AL133080, AL122050, AL049430, X70685, AL049314, E02349, AL137550, AL117457, AL133016, S78214, AF177401, AL117440, AL110225, AL117394, AL133606, AF079765, X63574, X96540, AL133560, AF111112, AF113019, X82434, AF090934, AF067728, A65341, A77033, A77035, AF087943, AF113699, AL137560, AL137271, Z82022, AF183393, AF090901, AL133072, X65873, A03736, AL137521, U91329, AF106862, AL050277, AL133067, AL122049, A90832, U96683, AF113691, AF017437, AF097996, Y11254, AL080159, AL133640, AL133557, AL133075, AL050149, AF125948, AF146568, U80742, AL133113, AL133565, AL049464, AR011880, A58524, A58523, AF113694, AF113677, AF118064, AF111851, AL137459, AL096744, AF061943, AF026816, AF091084, AF003737, AR038854, AL049300, AF118094, AF090943, Y10080, AL117460, Y09972, L31396, AL133014, U42766, L31397, X72889, E07361, AL049938, AL049283, AL122111, AF153205, AF090900, AL110280, X98834, E08263, E08264, AJ006417, I00734, AL110197, AF132676, E00617, E00717, E00778, AF162270, S61953, AF061836, AL050172, AL137705, U58996, M86826, X92070, A08908, L30117, A07647, E02221, AL080074, Z72491, AI8777, AF106827, AL133098, E08631, AF008439, Y10655, AR038969, AF051325, AL137523, M30514, AF079763, AF057300, AF057299, AL137476, AL137526, A45787, X62580, AF210052, I17767, AF081197, AL137429, E05822, AL122045, AL133031, I96214, AR034830, AL122118, I41145, AL080086, AR013797, AL137273, E04233, AF111849, U68387, U78525, AL137480, S76508, X87582, Z37987, AL137533, and Y07905. HTEJN10 1177 958389 1-412 15-426 AA397714, and AI688816. HTEJN49 1178 558383 1-244 15-258 AL033527. HTEJN96 1179 573845 1-341 15-355 HTEJP10 1180 914785 1-406 15-420 AA173098, AA330453, N72370, AA382609, D82507, AA305139, AA376308, AA319043, AA360655, AA204809, N47351, L48818, T97397, H74112, AA303102, N98390, T85235, R92534, AI400282, W78773, AA226439, N77177, AA135383, AA089951, N28003, AA094694, AA036797, and D82374. HTBJP66 1181 916481 1-697 15-711 AW402599, AA402458, N28458, W04863, AA683291, C17218, AA452695, AA321934, AA325890, AA148436, AA083939, W95796, AA203350, AA373216, H87410, R96313, N29206, W60562, N55788, W32702, N40125, AA319796, T27329, AA360583, H49227, AA402577, AA027923, AA115050, AA150348, AA496191, W05840, N35260, AA382795, AA210879, AA346660, AI902181, AF172940, AF151885, and AC007298. HTEJP71 1182 767955 1-616 15-630 H59767, AA252573, R52747, AW303359, AW151618, AA811707, AA939308, AI205601, and X80437. HTEJT37 1183 530596 1-339 15-353 AI092208. HTEJT74 1184 676254 1-438 15-452 AA393248, AA393292, AI796754, AA293815, AA459841, AI075905, AW137492, AI652522, AI217933, AI150346, AI694956, AA399502, AA398164, AI024099, AA719008, AA629029, AA861041, AA402463, AA435622, R24468, R66361, AA688372, AF081250, and AF081249. HTEJU30 1185 573823 1-304 15-318 AC000093. HTEJV62 1186 694525 1-325 15-339 AA813665, AI025041, and AI215603, HTEJX78 1187 806395 1-411 15-425 AA496111, AW138142, AA306268, AA417106, AA382596, AI027705, AA383788, AI824924, AA382469, AA812546, AA382920, AI183592, AA383156, and AI828862. HTEJY21 1188 530156 1-426 15-440 AI695191. HTEJY27 1189 685272 1-239 15-253 AA853991, AA778707, AW182416, AA634398, and AA609856. HTEJZ26 1190 523818 1-262 15-276 AW247046, AA401701, and AA398161. HTEKC07 1191 920925 1-389 15-403 AW087802. HTEKC12 1192 815975 1-345 15-359 AI539455, AI218279, AI348415, AW408773, AW340548, AI368160, AA894774, AA937067, and AW364691. HTEKD04 1193 519938 1-418 15-432 HTEKE41 1194 974044 1-735 15-749 AI091681, AC009405, AC003683, AJ239321, AC007253, AL009173, AL030995, Z99572, and AL109853. HTEKE46 1195 870084 1-1112 15-1126 AI125483, W77994, AI161017, W73951, AI250771, AA777158, W94063, AA912611 AA339877, AI265865, and AA339786. HTEKE80 1196 790381 1-523 15-537 HTEKF04 1197 774260 1-732 15-746 AA609512, AW074860, AW119172, AA626238, AA759162, AA609090, AA421396, AW070485, AA421292, AW303549, and AC007999. HTEKF24 1198 573750 1-412 15-426 AF001846. HTEKF35 1199 573749 1-253 15-267 HTEKF68 1200 772997 1-567 15-581 AW263561, AW183891, AI005584, AJ216442, AA983878, AA815385, AA868890, and AJ004495. HTBKI01 1201 917176 1-416 15-430 HTEKI70 1202 503039 1-686 15-700 AI830436, AA187445, AA383192, H91927, AI640587, and AI989949. HTEKJ48 1203 530588 1-235 15-249 HTEKM14 1204 745257 1-312 15-326 HTEKO49 1205 723148 1-383 15-397 AA699599, AI275162, N27054, R09201, and AC006211. HTEKQ26 1206 870627 1-314 15-328 HTEKQ85 1207 784444 1-555 15-569 HTEKR75 1208 870555 1-412 15-426 HTEKS15 1209 529273 1-414 15-428 HTEKS20 1210 846714 1-1063 15-1077 AI936596, AA868353, AI797296, AA725553, AI221970, AA429551, AA428462, AA629305, AA629047, AA431190, AI073397, AW235895, AI123443, AI808267, AA609412, AI914363, AA953895, AI214385, AA431516, AA911681, AA781953, AI825106, AA298758, AI215028, AA909534, AA723768, D10393, and S63991. HTEKS21 1211 506651 1-333 15-347 HTEKS76 1212 767658 1-495 15-509 AI990484, AI917746, AW182169, AI216456, AA723888, AI018419, and AA969884. HTEKX06 1213 935945 1-426 15-440 HTEKX08 1214 959876 1-490 15-504 AL042392, AI147451, AA758821, AW450252, AA399310, AI656343, AI636668, AI190733, AA725709, AI025812, AA398244, AA723645, AA382463, AA709253, AI139837, AA401777, and A57391. HTEKX28 1215 920927 1-286 15-300 AA393705. HTEKX70 1216 573700 1-304 15-318 HTEKZ50 1217 524054 1-304 15-318 H89084, AA296876, AL023876, AC011422, AP000962, AL020989, AL049563, AL022575, AL031183, AL009028, AL031391, and AC002487. HTELA50 1218 774268 1-497 15-511 AI670826, AA058736, and Z99297. HTELD47 1219 934272 1-1005 15-1019 AA229071, and AA229024. HTELD82 1220 779315 1-510 15-524 AI377684, H03750, H84635, AA625639, and R22878. HTELE10 1221 963563 1-495 15-509 HTELE41 1222 791743 1-601 15-615 AI684943, AW117611, AI418517, and AI418516. HTELG47 1223 757740 1-442 15-456 HTELG57 1224 870621 1-441 15-455 HTELG80 1225 773018 1-251 15-265 AW341441, AI651145, AI919149, AI247339, AA412289, AI218635, AI650567, AW340087, AA709187, AW118140, and AW183314. HTELH44 1226 766462 1-658 15-672 AI298565, H92427, AW452904, AI361759, AW449414, AA004711, R75764, F04362. HTELI03 1227 923071 1-575 15-589 AC005157. HTELI51 1228 806403 1-654 15-668 AI022339, and Z99127. HTELJ89 1229 966134 1-376 15-390 AA397525, AA399055, AA758883, and AL022101. HTELK14 1230 794339 1-453 15-467 Z99716. HTELK50 1231 870552 1-227 15-241 AL078475. HTELK68 1232 923055 1-646 15-660 HTELL48 1233 783824 1-515 15-529 HTELL51 1234 952267 1-635 15-649 HTELL90 1235 952269 1-940 15-954 AA913156, AI221124, AA305153, and AF106564. HTELM89 1236 786268 1-288 15-302 AI591200, AA102066, AI867662, AW088720, and D26018. HTELO20 1237 926910 1-420 15-434 AL031597. HTELO51 1238 931120 1-378 15-392 AI540890, AI557426, AI557082, AI541027, AI547225, and AI541056. HTELO73 1239 761806 1-514 15-528 AL078613. HTELO93 1240 934344 1-249 15-263 HTELP27 1241 921621 1-564 15-578 R80089, X85707, and X85708. HTELQ41 1242 922634 1-449 15-463 AA310475, AI536833, AA319470, AA278518, AA319408, W20004, AI611260, AA418173, AI968286, AW182252, AA315267, AA491655, AW170378, and AI904985. HTELQ87 1243 761768 1-449 15-463 AI125340, AI125684, AI377949, AA884214, AI126470, AI218351, AI243952, AA723933, AI240603, AI143979, and AI187742. HIELR90 1244 826531 1-437 15-451 AA652491, and AF152924. HTELT72 1245 761598 1-447 15-461 AI827560, AI336053, AA873745, AA451732, AI436724, AA923591, AA055247, AW189536, AA747873, and Z40977. HTBLT83 1246 780619 1-699 15-713 AA746627, AA398848, AA435892, AI208905, AI024568, AA861337, AA861875, and AA910621. HTELU01 1247 915339 1-367 15-381 AL033517. HTELV06 1248 934302 1-457 15-471 AI799028, AW263660, AA861674, and AA993711. HTELV10 1249 963576 1-256 15-270 HTELV26 1250 796832 1-435 15-449 AI198878, AI190586, AI018804, AL042837, AI208256, AA725583, AI016643, AA833661, AA626323, AA993365, AI018351, AA718913, AA725636, AA992718, AI183840, AA403023, AI911045, R60037, AA398422, AW410573, AA749431, AI128961, AI077415, AI198777, AI439996, AI934676, AI199096, AA682387, H92998, AI200368, AA778651, AA045098, AW157530, AW250790, AA587915, AW188549, AI819989, AI951978, AW007464, AI951992, AI376410, AI677931, AA778720, AI364379, AA584288, AW162769, AI040155, AA150015, AI187131, AA977318, AI373112, AI000432, AI038499, AI076148, AI278114, W94564, AA513466, AA946608, AI279549, AI758476, AW103741, AA836837, AI700221, AI253749, AI913907, AA057355, AI038357, AI758826, H71311, AW004637, AW273537, AA186980, AI885648, AA824341, W70033, T35014, AI262733, AI693026, AA196549, AI868298, AI090830, T16464, AL042836, AI887548, AW025276, AI139138, and AA150080. HTELV43 1251 870615 1-434 15-448 AC007746. HTELV86 1252 910946 1-1086 15-1100 AI272244, AA382531, AI809639, U35371, and X99043. HTELW29 1253 952241 1-768 15-782 AW117507, AW105238, AW105158, AA969617, AI692859, AA934716, AA383047, and AI917691. HTELW62 1254 870596 1-486 15-500 AA393684, AA813816, and AI700752. HTELX52 1255 963506 1-345 15-359 AI220445. HTELX72 1256 761599 1-216 15-230 HTELY64 1257 764834 1-437 15-451 HTELZ07 1258 952268 1-535 15-549 HTELZ89 1259 786424 1-451 15-465 HTEMA54 1260 911666 1-1484 15-1498 AI954673, AI220421, AA813119, AA382989, AI024406, AF113526, AB023063, and HTEMB26 1261 827055 1-130 15-144 AC004900. HTEMB28 1262 870614 1-402 15-416 HTEMB34 1263 870589 1-533 15-547 HTEMB72 1264 761602 1-294 15-308 HTEMB83 1265 775593 1-370 15-384 AA778498, AI337034, AA609166, AA625857, AI201263, AA437287, AI678062, AI961118, AI203907, AI917789, AA626247, AA927799, AI187708, AA442366, AW294301, and AL050341. HTEMC18 1266 924727 1-447 15-461 AI813375. HTEMC75 1267 848193 1-296 15-310 M78994, R86687, T08961, AW402241, R46318, AA349761, AA350295, AA354235, H15340, AI909793, D31764, and AF037332. HTEMD10 1268 963546 1-673 15-687 AA625914, AA416795, and AC005858. HTEMD73 1269 761783 1-430 15-444 AI026681, AA609997, AA382092, AA789295, and T12649. HTEMF08 1270 958386 1-494 15-508 HTEMJ34 1271 786377 1-550 15-564 AI142370. HTEMJ54 1272 963531 1-558 15-572 H59039. HTEMK03 1273 923066 1-347 15-361 HTEMM80 1274 888686 1-869 15-883 AA759198, and AA968427. HTEMN08 1275 958374 1-232 15-246 HTEMN95 1276 789113 1-311 15-325 HTEMO14 1277 880634 1-407 15-421 HTEMO85 1278 771434 1-485 15-499 AA804990. HTEMP48 1279 767863 1-348 15-362 AL049761. HTEMP49 1280 932319 1-774 15-788 AA933702, AL036538, AA928649, AA393559, AW104883, AA974777, AA587615, AA594505, AI351083, AA406036, AI004273, AI217923, AA923027, AA435495, AI128197, AA496058, AI187946, AI026847, AA865921, AA383556, AA927439, and AL117564. HTEMR65 1281 909280 1-1112 15-1126 AW003084, AA574346, AW188065, AI657112, W37979, AW162204, W37760, AW172598, HTEMS10 1282 963527 1-386 15-400 AW082687, AA774543, AW195592, AW274057, AA460327, AA382893, AI126206, AI198578, HTEMS48 1283 832506 1-341 15-355 AA045732, AA412195, T70810, T85978, H26344, AA293873, AI343622, and AC004231. HTEMT06 1284 934338 1-636 15-650 AI016782, AI149777, AA448011, AA448155, and AI285926. HTEMT89 1285 922999 1-630 15-644 AW003548, AA757091, AW014801, AA813302, AA437209, AP000220, and AP000084. HTEMU17 1286 789623 1-335 15-349 W90717, and W90708. HTEMU54 1287 870618 1-436 15-450 AP000470. HTEMX92 1288 913795 1-525 15-539 HTEMY30 1289 870662 1-219 15-233 AL048534, AA403281, N78348, and AL031255. HTEMZ04 1290 927021 1-363 15-377 HTENA22 1291 870601 1-720 15-734 AL080132, AC011594, AC006238, R38805, R49132, R49132, H06801, N66174, N98697, AA043641, AA146965, AA147010, AA259116, AA259155, AA534491, AA570283, AA687335, AA766643, AA910635, AA948152, AA401719, AA609258, AA626320, AA644562, AA680291, AA757030, AA758747, AA888971, AI023819, AI032507, AI088947, AI274536, AI345946, AI431770, AI192387, AI214901, and AI217881. HTENB03 1292 923050 1-476 15-490 HTENC22 1293 775544 1-560 15-574 AW195712,D44825,AI124542, andAB032984. HTENF08 1294 958378 1-743 15-757 HTENF95 1295 795316 1-333 15-347 AI473748,AI798241,AA279454,AL138273, andAW149414. HTENG66 1296 840151 1-295 15-309 HTENG93 1297 967432 1-91 15-105 HTENH86 1298 784798 1-601 15-615 AA393073, AI139819, AA860114, AA412161, and AA868102. HTENI58 1299 917213 1-636 15-650 AI970129, AW237169, AI621267, AI653036, AI797400, AI797725, AW182923, AI961057, AI970364, AI191623, AL036577, AW188292, AI341330, AI655836, AA918201, AI202983, AI825213, AI824962, AI990770, AA890172, AI982569, AI918790, AI205504, AI611043, HTENJ28 1300 968135 1-1014 15-1028 AI240133, and AF032967. HTENJ76 1301 767838 1-431 15-445 AF012383, AI307797, AW270088, and U86074. HTENK06 1302 835851 1-552 15-566 AB020719. HTENK69 1303 844557 1-899 15-913 AL042436, AL042437, AI674705, AA400083, AW241753, AA401372, AI218464, AA953011, AA972296, AA812520, AI125824, AA437087, AI028669, and AI024321. HTENO12 1304 917032 1-1454 15-1468 HTENO50 1305 969213 1-635 15-649 AA905347, AA371108, T20204, Z43158, and AA151400. HTENP54 1306 787535 1-494 15-508 AA496169, and AC009411. HTENP80 1307 775387 1-482 15-496 AL035453. HTENQ05 1308 928244 1-641 15-655 AA393064. HTENR10 1309 963530 1-575 15-589 HTENR74 1310 764828 1-444 15-458 AI823791, and AF069682. HTENR93 1311 920834 1-875 15-889 AI381463, AA634395, AA406053, AA405219, AA383176, and AF121781. HTENS22 1312 785996 1-532 15-546 H83100, AL044519, and AL137391. HTENS43 1313 784936 1-1079 15-1093 AI971582, H58143, AI499833, AI393537, and AA973074. HTEN591 1314 870515 1-720 15-734 AA225153, AA629286, AA225136, AI272649, AA909816, AA070899, AI866377, AA229443, R67086, AA084212, AW243884, H59093, AA158549, AC002086, AL133304, AC000004, AL049830, AC006050, AC007270, AL031846, AC006125, D43727, AL031670, AC002470, AL050318, AC007114, AF001549, AP000329, AL135959, AC003070, AL034420, AL031286, AC007226, AL049694, AC004143, AL022476, Z93244, Z68284, AP000359, AC005015, AL034429, AC000394, AC006120, AC003029, AL031589, AC004782, and AL035072. HTENV57 1315 944416 1-605 15-619 HTENW53 1316 907717 1-806 15-820 AA429691, AA429515, AC007114, Z61140, and AC004156. HTENX77 1317 771409 1-521 15-535 AA781188, AA460513, AA860910, AA781845, AI027285, AI208471, AA889700, N73782, H08088, R38703, F03385, AI830535, AI474644, R41444, AA459870, AI023552, and AA421081. HTENY21 1318 870587 1-705 15-719 AI743533, AI424822, AW082413, and AI915340. HTENY35 1319 884043 1-1011 15-1025 AJ223811, X85630, T36006, AA382232, Z21393, AA383107, N78092, T36070, T36050, Z21341, Z21392, AA459806, Z21315, AF012377, Z21111, AI827647, AW340665, AA280976, Z21340, T85719, AL043525, AL043526, R82847, AC006208, and AL137671. HTENZ16 1320 917185 1-962 15-976 AI018671, AI807205, AI468026, AI797263, AI025828, AW194247, AI889876, AA843455, AI884356, AI198561, AI032059, AI126485, AI889886, AI239452, AA992969, AA780875, AW303976, AI216470, AA683361, AI569512, AI472962, AI885458, AW055338, AW242149, AI911290, AI222107, AI538002, AA912612, AW183126, H79395, AA884115, AI149911, AW189703, AI220396, AI203939, AA936147, AI560168, AI219573, AW243836, AA906293, AI252658, N26330, N26296, AI886564, AW085495, AA927058, and AL133596. HTENZ33 1321 870591 1-616 15-630 AA383398. HTENZ72 1322 773024 1-564 15-578 AI632084, AI221893, AA383392, AA759214, AW137663, AI269516, and AA923222. HTEOA90 1323 787516 1-489 15-503 AA383437. HTEOD34 1324 812307 1-552 15-566 AI990671, and AI990110. HTEOE61 1325 918635 1-548 15-562 HTEOF31 1326 793202 1-619 15-633 AL031283. HTEOF80 1327 847224 1-506 15-520 AF186084, and AL117610. HTEOF85 1328 768583 1-494 15-508 AI917508, AI810095, and AA973064. HTEOF91 1329 918571 1-237 15-251 HTEOI36 1330 870575 1-516 15-530 AA298760, AA298759, AA298601, and AL133073. HTEOI53 1331 810333 1-422 15-436 AW206247, AI400618, AI671128, AW237084, AI811276, AI337166, AI341186, AI360596, AW235137, AI183637, AI654814, AI654771, AI969744, AI954759, AA417208, AI969746, AW087480, AA417104, AW182372, AA723770, AW241414, AW003345, AW241474, AW183339, AA432142, and AA757062. HTEOK02 1332 918590 1-395 15-409 HTEON29 1333 815852 1-978 15-992 AW004028, AI968030, AW237673, AA432290, AW138422, AA112090, AA428635, AI143780, AI143791, and AA861634. HTEON67 1334 954114 1-335 15-349 AC004533. HTEOU45 1335 915138 1-639 15-653 HTEOV90 1336 870532 1-425 15-439 AW204420, AW058611, AI767863, AI433866, AI671711, AI802010, AI935766, AA280379, AI808931, AA523871, AI193461, AA827208, AA418269, AI302010, AA280200, AA251664, AI637584, AI932794, AI564719, AI677796, AI538716, AI633125, AI862139, AI433157, AI702073, AI476046, AW050522, AI924971, AW151786, AW198090, AI569583, AI591420, AI590227, AI619502, AW102785, AI826225, AI648663, AI863240, AI886753, AW075381, AI480118, AI270183, AI097248, AI567351, AW152182, AI434468, AW104724, AI863321, AI612759, AI679916, AI271796, AI922365, AI890833, AI926790, AI802542, AI799199, AI636719, AI241819, AI280637, AI696612, AI828731, AI873644, AA833760, AI915291, AI445992, AI874261, AI804983, AI923357, AI670009, AI560099, AI613017, AL036187, AI572787, AI570807, AW026882, AI536638, AI620003, AI624548, AI537244, AA449768, AI433023, AI934026, AW104827, AI537303, AI274508, AI273142, AI955906, AL041772, AI811785, AI796743, AI446248, AA857306, AI863382, AI554427, AI445025, AI274013, AI520702, AI446003, AI889376, AW051258, AW150453, AI699865, AI925156, AW151136, AI923370, AW148320, AI619716, AI539808, AI869367, AI689248, AW075413, AI619607, AI499285, AW029611, AI698391, AI249962, AI680498, AI567814, AI889189, AI554821, AI539153, AI554218, AI784252, AW170635, AI608936, AI569945, AI635464, AI432040, AI537273, AI817552, AI564723, AI612852, AI681985, AI432969, AI828367, AI559296, AI702433, AW075667, AI432030, AI366900, AW148408, AI436644, AI633308, AW169527, AW090550, AI569328, AI627909, AI800411, AI612920, AI919534, AI921176, AI280661, AI499381, AI469112, AI580984, AI934259, AI539687, AI567128, AW193530, AW073270, AI648502, AI783861, AI610690, AI889306, AW169653, AI648684, AW081036, AI491775, AI801523, AW054964, AI469532, AI702068, AW148363, AI819976, AW080992, AW152469, AI273839, AI687127, AW192652, AI249877, AW087207, AI655932, AI680377, AI453322, AI439452, AI439762, AI648509, AI579901, AI818980, AI439717, AW235482, AW243820, AI357316, AI285735, AI497733, AI696606, AW193236, AI687362, AI589273, AI921464, AI623396, AW190042, AI280747, AI963216, AI284020, AI816010, AI628205, AI365256, AI758512, AI619737, AI886206, AW087534, AI352497, AI625079, AI813919, AW129916, AW129722, AI868204, AI587114, AW128841, AI610086, AI683173, AI560171, AW129230, AW190194, AI590423, AI281762, AI859511, AI921248, AW149925, AI493567, AI521103, AI569579, AI499393, AI370390, AI271786, AI887151, AI357940, AW149869, AI470648, AW131294, AI628316, AI520931, AI682971, AI871697, AI571439, AW083175, AI866801, AI824648, AI640379, AF113694, AL080060, I89947, A08910, A08909, I48978, A08913, A08916, AF090934, AL049430, I48979, AL050393, AL137463, AL133560, AF177401, AB019565, AF113690, AF118094, AF125948, I89931, I49625, AF090901, AF104032, AF090896, I33392, AF090903, AF090900, AL137557, AF078844, AL122110, U67958, A77033, A77035, AL137271, AJ012755, 578214, AL117457, AF079765, AL050024, AF087943, AF113013, AL049314,AL110196,AL133640,Y14314, 568736,A03736,A65341,AL133080, AL049382, Z82022, AL122121, Y16645, AJ000937, AL122050, A93350, E07108, AL050116, AF125949, AL096744, AL080124, AL137527, AF091084, AF118064, AL137550, E02349, X82434, U72620, AF067728, AF113699, AF113019, E03348, I26207, U35846, AL049283, AL080159, AF183393, AL117460, AL122098, AL110221, AL050149, AL117394, AL122093, AR011880, I03321, A93016, AF090943, AF097996, AL117583, AL050108, AL080137, AL133113, AL133072, U42766, U00763, AL049466, A08912, AL049938, AL133016, AL117435, X72889, I42402, AL137459, AF017152, U80742, AI2297, X65873, AL137521, AF106862, AF113689, AF113677, Y11587, AF111851, AR059958, AJ238278, AL133093, AF118070, Y11254, AJ242859, AL050277, AL133075, AL133606, X63574, AF061943, AL049452, AL049464, AL122123, X84990, AL117585, X96540, A58524, A58523, AF017437, E15569, AF113691, AL137523, L31396, AF146568, X93495, AL133565, L31397, AL049300, I09360, X70685, AL137648, AL137538, AL133557, AL080127, AF113676, AF158248, AL050146, AL110225, AL050138, U91329, E07361, AF185576, AL137283, AL137560, AL133098, AF026816, AF119337, AL133104, AF111112, AL110280, AF153205, AL133665, AL133568, AL110197, AF026124, X98834, I00734, A07647, AL137556, AR038854, AL050172, AR000496, U39656, Y09972, AL137480, E08263, E08264, AL122049, AL133077, AL133014, Y07905, AF106827, E00617, E00717, E00778, AF057300, AF057299, AF079763, AC006222, X80340, AL137476, AF003737, U58996, AL023657, AL137533, X87582, A45787, AL050155, S61953, AR013797, AL117440, AR038969, AL137526, A90832, I66342, AL080074, AF162270, AL133067, E05822, AF111849, AL050092, AF061981, AF000145, E04233, Z72491, U78525, AF106657, E06743, AF051325, M30514, U96683, AJ006417, AL137292, AF008439, AF177767, U49908, L30117, AF061573, L19437, AL122118, AL137488, I96214, AF132676, AF061836, AP000020, E08631, U68387, E02221, S79832, Z37987, AF210052, I17767, AL022147, and AR020905. HTEOW02 1337 918475 1-596 15-610 HTEOW39 1338 870566 1-488 15-502 Z98304. HTEOW85 1339 969682 1-649 15-663 AI684621. HTEPA08 1340 958391 1-1054 15-1068 AI041556, AL042783, AA834968, AA789271, AI032390, AA400082, AA757197, AW206997, AA416988, AW235392, AI028342, AI024253, AI015964, AL040413, and AA411964. HTEPA27 1341 872923 1-589 15-603 AI765491, AI469067, AI870585, AI870612, AI652881, AA055971, AI763357, AA056000, AA358708, AA889873, AI701794, N56631, AL042137, AI825129, AW297101, and AB018353. HTEPB66 1342 772949 1-610 15-624 AW449288, AI147992, AI142275, AI654490, AI002885, AI743450, and AW103158. HTEPB84 1343 782248 1-580 15-594 HTEPC76 1344 767824 1-526 15-540 AI688792, AA504908, AL138425, AA908950, AI208672, and AF081466. HTEPC87 1345 883021 1-514 15-528 HTEPD06 1346 933299 1-341 15-355 N47565, N47576, C14331, D80227, D80269, D80378, C14429, D51799, C14389, AW118681, D80391, D59787, D59467, D80196, D80038, D59927, D50995, D58283, D59859, D80022, D80166, D80195, D51423, D59619, D80210, D80164, D59275, D80240, D80253, D80043, D59502, D81030, D81026, D51022, D80212, AA305578, D80188, D59610, D80219, AA514186, AA514188, C15076, D57483, D80024, D80366, AA305409, D50979, D59889, D80193, D80045, C14407, D80133, AW360811, D80241, D80248, D80522, D51060, AW177440, C14014, D80251, AW178893, AW375405, T03269, AW179328, C75259, AW366296, AW377671, AW360844, AW375406, AW360817, AW378534, AW179332, AW377672, AW179023, AW178905, D80268, AW378532, D80132, C05695, AW352171, AW177501, AW177511, D80302, D80134, D80439, AW377676, AW352170, AW177731, AI557751, AW178907, AW178762, D58253, AW179019, AW179024, AI535686, D80247, D51250, AW369651, AW177505, AW178906, AW352174, AW179020, AW178775, AW360841, AW178909, D59373, AW177456, AW179329, F13647, AW178980, AW177733, AW378528, AW178908, AW178754, D52291, C14227, AW179018, AW352158, AW352117, AW176467, T11417, AW179004, AW367967, AW179012, AW178914, AW378525, D51103, D80168, AA926689, AA809122, AI910186, D80157, C14344, AW177728, C06015, AW179009, D51759, D58246, D81111, AW178774, AW178911, AW378543, AW177722, AW352163, C14298, D80064, AI905856, D59503, AW178983, AW178781, T48593, D58101, AW360834, Z21582, AW177723, AW378540, AW352120, D59627, D59653, D80258, AI535850, AW378533, D45260, D51097, C14975, Z33452, AW367950, D80014, AA285331, AW177508, H67854, C03092, H67866, AI525920, AI525923, D51213, AW177497, D80228, AW178986, C14973, D50981, D45273, N66429, T03116, AI525917, D59317, AW177734, D51221, D59474, D60010, AA514184, D59551, C14957, D60214, T03048, AI525235, AI535961, AI525227, C14046, AI557774, AI525242, AI525912, AW378542, AI525925, AW378539, AI525215, A62298, A84916, A62300, AR018138, Y17188, A82595, AB028859, AJ132110, AF058696, AR008278, Y17187, X82626, X67155, D26022, Y12724, A25909, A67220, D89785, A78862, D34614, D88547, A94995, AR060385, AB002449, AR008443, A30438, I50126, I50132, I50128, I50133, AR025207, AR066488, X64588, AR016514, X68127, AR060138, A45456, A26615, AR052274, AR066490, Y09669, A43192, A43190, AR038669, I18367, AR066487, AR008277, AR008281, U46128, I14842, AR054175, AR016691, AR016690, AR062872, AB012117, D50010, A63261, AR008408, X93549, A85396, A70867, D88507, AR066482, A44171, U79457, A85477, I19525, A86792, I79511, D13509, A64136, A68321, AR060133, AF123263, AR032065, and AR008382. HTEPE28 1347 932576 1-694 15-708 AA205046, AA383391, AI184616, AA223825, AI825541, AI469846, and D42084. HTEPG15 1348 812303 1-533 15-547 AI937640, T18881, R24582, AA412546, AI083751, AF079564, AF079565, AF106658, AF106659, AF202454, AF202453, and Z63351. HTEPH01 1349 915301 1-618 15-632 AA399486, T69681, and AC007537. HTEPJ09 1350 956200 1-1202 15-1216 AA394192. HTEPJ19 1351 918599 1-453 15-467 T18597, D59751, AI557262, AI525556, Z33559, AI540903, Z32887, D50992, AI557533, AI536138, AI535660, AI541205, D59436, AI526078, AI535639, AI541321, AI541075, C14228, AI557864, AI557238, AA058620, AI557808, AI525500, AI557082, H65400, AI525653, AI535828, AI557809, AI541356, AI557602, AI541365, AI557731, AI525302, AI525316, AI535813, AI546829, AI525757, AI540974, AI557312, AI557317, AI541154, R29657, AI536150, AI541034, AI557852, AI525856, AI535994, AI541353, AI541027, AI541048, AI557258, AI557543, AI525666, AI557041, AI557426, AI536070, AI557039, AI557810, AI525656, AI547177, D30843, AI557408, AR050070, A62298, A82595, A82593, U94592, Z30183, A62300, AF006072, and AR025466. HTEPJ79 1352 774212 1-359 15-373 HTEPK40 1353 939675 1-619 15-633 AI075905, AI796754, AW137492, AI652522, AA393248, AI217933, AA459841, AI150346, AA293815, AI694956, AA435622, AA393292, AA719008, AA629029, AI024099, AA861041, AA398164, AA402463, AA399502, R24468, R66361, AA688372, AF081250, and AF081249. HTEPM33 1354 870561 1-816 15-830 AA824347, AA889787, AI425084, AA868962, AI190895, AL132776, and AF083394. HTEPM52 1355 806471 1-444 15-458 HTEPN07 1356 952243 1-307 15-321 Z99716, HTEPP23 1357 836572 1-327 15-341 AI150152, AI216505, AW103179, and AC006017. HTEPP29 1358 917207 1-458 15-472 HTEPP30 1359 947107 1-732 15-746 AF191546. HTEPP32 1360 785803 1-963 15-977 AA402763. HTEPP92 1361 790869 1-596 15-610 HTEPR90 1362 787499 1-155 15-169 HTEPT25 1363 870509 1-393 15-407 HTEPT75 1364 870637 1-630 15-644 AI283483, AI873282, and AI827738. HTEPU01 1365 915134 1-704 15-718 HTEPV02 1366 917406 1-489 15-503 HTEPX32 1367 870698 1-1349 15-1363 AI217947, AW237109, AI918745, AI968403, AA934788, and X84693. HTEPZ10 1368 963433 1-529 15-543 AI217204, AW183426, and AA759358. HTEPZ18 1369 888470 1-560 15-574 AA397836, AI139919, AW162347, AI223276, AI879324, AI200822, AI150592, AI028601, AI200868, AI879701, AI138943, AI652314, AI377443, AA868111, AW160551, and AF177398. HTEQB03 1370 922941 1-396 15-410 AI624244, AL120897, AL121756, AC007099, Z99496, AC004584, AC002418, AP000248, AC004386, AL050305, AC002483, AL022315, AL034452, AC004638, AC005899, AC000353, AC004623, Z84476, and U91323. HTEQD40 1371 915198 1-543 15-557 AI623182, AA776747, AW082325, AW273819, AI539350, AI810085, AI125567, AI221672, AI200770, AI204194, AW263528, AI240146, AA437189, AA758317, AI192035, AA709217, AA992316, AA758401, AA961979, AI217262, and Z66485. HTEQD69 1372 918579 1-607 15-621 HTEQE87 1373 958354 1-72915-743 AA913948, AI633873, AI638029, AI990760, AI806847, AW003193, AI190550, AA431560, AI187284, AI915840, AI286045, AI243468, AA719044, AA448281, AI219847, AW135537, AA861812, AA861291, AI969788, AA812901, AI187727, AI286137, and AI942348. HTEQG56 1374 881004 1-577 15-591 HTEQJ54 1375 853971 1-603 15-617 AW299627, AA917835, AA758010, AI989828, AW103119, and AW241908. HTEQJ14 1376 870525 1-496 15-510 HTEQJ42 1377 806495 1-496 15-510 AA383039. HTEQ081 1378 806504 1-375 15-389 AA382997, and AA397859. HTEQP45 1379 966141 1-127 15-141 HTEQQ82 1380 932301 1-590 15-604 AA609033, AA293870, AA382673, AW263657, and U51244. HTEQR15 1381 939641 1-756 15-770 AI979286, AA382595, and AF133424. HTEQR94 1382 966486 1-556 15-570 AI990882, AA447560, AI201149, AI341615, AW002367, AI651854, AA437021, AI149956, AI140621, AW292211, AA620811, AW196416, AA757082, AA993629, AA932499, N92273, AA448543, AI458277, AA398159, AW004057, AI918824, AI635506, AA401699, AA994466, and AI016246. HTEQT63 1383 924799 1-1298 15-1312 AI142296, AA417385, and AI148005. HTLAB19 1384 530577 1-347 15-361 HTLAB44 1385 530579 1-253 15-267 AC006549, AC000097, and AC006547. HTLAB73 1386 575019 1-320 15-334 AC000078. HTLAC81 1387 679414 1-192 15-206 AF038406. HTLAC87 1388 546469 1-226 15-240 HTLAD21 1389 761758 1-490 15-504 AI217166, AI184534, AI150079, AI142754, AI697160, AI811701, AI214713, and AW188915. HTLAD38 1390 421550 1-517 15-531 HTLAF84 1391 836390 1-558 15-572 AA418228, AF045454, D63648, and E13935. HTLAV67 1392 530742 1-208 15-222 AC005258. HTLBD12 1393 506739 1-319 15-333 AL121757. HTLBE55 1394 967408 1-293 15-307 AL036680, AA421020, AW151136, R66759, AL037558, AL045421, AA830821, AW149876, AI571529, AI355008, AI567582, AW089006, AI471361, AW023338, AW020095, AL041150, AW167924, AI829990, AI345224, AI079736, AL046463, AI311892, AW162194, AI697324, T99953, AW243637, AI921167, AA291456, AI539771, AI873638, AI473451, AI805688, AI888621, AI828574, AW022682, AW239367, AI540606, AI689420, AI336662, AL038575, AA464646, AW020693, AI890887, AI590423, AI570966, AI307507, AI916419, AI611728, AI470293, AI929108, AI538850, AI610667, AA572758, AI648567, AW088899, AI805638, AI366549, AI799195, AI866082, AI636719, AI539153, AI620093, AI866608, AI636619, AL120853, AI340603, AI537677, AI611743, AW083804, AI349598, AI582912, AW172723, AI539800, AI696626, AI349256, AW075207, AI589993, AI866573, AI312152, AI365256, AA579232, AA807088, AI343037, AI345735, AW085786, AW265004, AW075084, AI310925, AL038564, AI472536, AI312399, AI677797, AW082600, AI349937, AI567944, AI345688, AI334884, AI307543, AI494201, N71199, AI345251, AW071412, AI307210, AI307708, N29277, AI312325, AW071395, AL036631, AI538885, AI249946, AI244380, AI340659, AI589267, AW071377, AW129230, AI802240, AW161579, AI313320, AI955906, AI340644, AI805769, AI434242, AI313352, AI335363, AI307503, AI539707, AI334930, AI309443, AI623682, AL039086, AI307736, AW161402, AI307520, AI623736, AI446124, AW084097, AI349266, AI349787, AI334452, AI340664, AI310592, AI344938, AI312146, AI866786, AI309431, AI312339, AI340537, AW301300, AI345739, AW161202, AI345674, AI345258, AI538764, AI312143, AI307459, AI349637, AA635382, AI273179, N74355, AI312428, AI499974, AI310927, AL110306, AI311604, AI307578, AA420722, AW162189, AI436429, AI349955, AW189933, AW075093, AI312432, AL120300, AA580663, AI349269, AI312357, AI590943, AI358701, AW021588, AI310945, AL040241, AW088903, AW151714, AL036638, AI636581, AI583445, AW059713, AI648408, AI312237, AI922901, AI446373, AW263716, AI251830, AI343059, AI917963, AI573026, AI349933, AW193467, AW268261, AW082623, AI249877, AL047422, AL133741, AA493923, AI345253, AW409775, AL119836, AI345677, AW167918, AA494167, AW191003, AI633402, AL119791, AW071362, AW021373, AI345608, N98606, AW191844, AI336513, AI357599, AI433968, AJ499581, AA848053, AI554821, AW264719, AL046618, AI348895, AI345347, AW269097, AI866465, AI310575, AI589428, AI349226, AL046595, AL040694, AA493647, AI537837, AW403717, AA974049, AL036718, AL037454, AI824360, AW058233, AL046466, AI569328, AI434833, AL038605, AW163834, AI886055, AF065135, I48978, Z72491, AF113690, AL035458, AL133104, AF158248, AL050172, AF090934, Y16645, AI8777, S78214, AL049382, AF090886, AF113691, A08916, AR000496, U39656, X70685, M86826, I89947, A08913, A08910, I26207, AL117585, I89931, A08909, A08912, Y11587, I49625, AL122118, AF036941, AL080074, AR038854, AF132676, AF061836, AF090900, A08908, AR011880, AL110171, AF090943, X84990, AL133016, AL122110, AF097996, AF118070, AL122050, AL137538, AL117457, AL133568, AF102578, AF028823, A65340, A07647, I48979, X53587, AL080060, AF114170, AF118064, AL133081, AJ238278, AF017790, AL122098, U68233, I92592, AL137712, AL080137, AL117394, E01614, E13364, A03736, M92439, AB016226, AF113677, I42402, AL050108, AL137705, AF067790, I89934, AF087943, E02221, AB019565, A65341, X62580, AL122111, AF210052, AL137574, AF125949, U68387, S68736, AE003737, I89944, AL133093, AL049466, Z37987, AL137658, U58996, AL050092, X87582, AJ000937, AF069506, AF118090, AF192557, AL096744, U78525, Y08769, X63574, A21103, 876508, AF113019, AL133558, AF215669, E02253, AL137560, AL133640, X52128, AF177401, AL080148, AL133565, AF104032, AF113013, AL049465, AL137300, I00734, S77771, I41145, AF012536, AL137429, AF113689, AL049300, E05822, AL137478, AL133645, U95114, AF176651, AB007812, E06743, AL080158, AF017152, AF026124, U96683, AL110221, S69510, AF113676, E00617, E00717, E00778, AL137656, D16301, AL137527, Y07905, AL050393, AL117435, AL137548, AL122121, AL110280, AL137463, AF111112, S61953, AL080086, AF078844, AL122049, E04233, X80340, AL117583, AL133098, AL117460, X72387, AL133557, X92070, AF090903, AL050116, AL122045, AJ003118, U49434, AL133014, U80742, AL133113, U91329, AJ005690, AL137479, U72620, D83032, AF162270, AL133560, AF126247, I09360, AL049938, X79812, AL122106, AL133075, AL122093, AL137294, U42766, AL117432, AF113694, AL137526, AL133080, AL117649, AL080127, AL133077, AF061573, U00763, AC002467, AL080124, AR068751, Y10655, S75997, AL049464, D89079, AL133067, AL137556, Y16258, Y16257, E02756, Y16256, X06146, AL137557, AL050024, U67958, AL049314, E01314, E07108, M27260, AL050149, A45787, AL133072, AL137273, AF106657, AF030513, AL050138, X93495, X65873, AL137665, E15569, A58524, AI8788, A58523, E03348, AL050277, U92068, AL110196, E03349, AR038969, L30117, AJ242859, AR059958, and Y09972. HTLBE82 1395 780116 1-467 15-481 H03896, AA788921, AA985315, and AL133595. HTLBF14 1396 971661 1-728 15-742 HTLBG83 1397 527942 1-187 15-201 AA132777, AA809070, and AI799864. HTLCA95 1398 911655 1-1148 15-1162 AI028227, AI798166, AI968058, and AI962770. HTLCG77 1399 772644 1-98 15-112 HTLCX76 1400 767667 1-265 15-279 AL045710, and AL096749. HTLCY27 1401 682208 1-288 15-302 W92263, AA736600, AI962876, AI539379, AI672273, AL045130, AI656897, AW001387, and AI806122. HTLCY54 1402 908832 1-1050 15-1064 AA453366, AI188219, AI638044, AA983750, AI219830, AA453265, and AA912820. HTLCZ48 1403 572959 1-399 15-413 HTLCZ96 1404 815897 1-459 15-473 AW139921, AA725842, AI971598, AI651885, AA453466, AL110422, AI027229, AI026797, AA778573, AI279962, AI073425, AI208767, H55405, and AL118498. HTLDA58 1405 828115 1-259 15-273 AA948538. HTLDE53 1406 780842 1-610 15-624 AA400498, AA400590, AA861265, AA398875, AI149809, AI198885, AA435582, AA460749, AA460151, AA889548, AI015434, and AA815269. HTLDE64 1407 908613 1-838 15-852 HTLDE95 1408 616724 1-285 15-299 AA566051, AA552211, AA393552, AA418209, H05646, H06920, R34733, AA293017, Z42496, AI743990, and AA280537. HTLDF33 1409 909254 1-616 15-630 AI376558, AI208582, AI149687, AI028197, AA629337, AI027966, AI202003, AA694500, AI701718, AW207552, AI336775, AI560530, AI215526, AW207059, and AI015601. HTLDG55 1410 911645 1-196 15-210 HTLDH65 1411 839795 1-901 15-915 N47989, AI675771, AI024189, AI651589, AI621081, AW003588, AW293606, AI026721, AA954294, N51195, and AA983886. HTLDI90 1412 835850 1-458 15-472 AB020719. HTLDO94 1413 915223 1-542 15-556 AA860341, AA889689, AA730148, AA478113, AI024743, AA730132, AA082366, and AA758028. HTLDP77 1414 920546 1-638 15-652 AC002128. HTLDQ25 1415 870057 1-1220 15-1234 AA399278, AA889597, AA758803, AW117336, AA398195, AA729781, AA889586, and AA922590. HTLDS55 1416 891322 1-1302 15-1316 AI890919, AI018797, AA913452, AI797580, AI809012, AI187382, AA448485, AI554914, AW137847, AI393577, AA382830, AA432050, AA609003, and AC020663. HTLDT05 1417 909752 1-473 15-487 R59447, R17647, T62170, and AI439348. HTLDT81 1418 952265 1-480 15-494 AA398001, AA399683, AW177623, AA809773, and AL137531. HTLDU05 1419 911649 1-589 15-603 AA437044, AF113527, AB023062, and AF113520. HTLDV31 1420 867748 1-297 15-311 HTLDX88 1421 791684 1-686 15-700 HTLDY85 1422 573746 1-481 15-495 HTLDZ14 1423 573401 1-334 15-348 HTLEB14 1424 573464 1-402 15-416 HTLED72 1425 906989 1-273 15-287 HTLEF94 1426 870258 1-309 15-323 HTLBG65 1427 870154 1-1167 15-1181 HTLEG91 1428 870257 1-99 15-113 Z94160. HTLEH30 1429 934287 1-542 15-556 HTLEI47 1430 573460 1-463 15-477 HTLEJ11 1431 973302 1-956 15-970 M62294. HTLEJ93 1432 960314 1-294 15-308 AL044506. HTLEK64 1433 506747 1-318 15-332 AA442457, AA601393, AC005625, and AC005789. HTLEL01 1434 917022 1-515 15-529 AC003976, AC005702, AC005562, and AL117394. HTLEL03 1435 575080 1-93 15-107 AF042793, AB011130, AF042792, AF040709, and Z84492. HTLEL07 1436 953712 1-581 15-595 HTLEL31 1437 669950 1-131 15-145 AA250913, W56681, R24109, H01291, AA161334, AW160808, and AF053356. HTLEM46 1438 719160 1-443 15-457 AI760165, AI341569, AW241888, AW135684, AI624778, AA883817, AI494564, AA722107, AA521079, and AA405142. HTLEO50 1439 506649 1-335 15-349 Z68869. HTLEP16 1440 574942 1-567 15-581 AA305510, AA099550, AI917501, AI631488, AI142135, AW391262, AA305581, N39659, AI829757, and AF151810. HTLEQ07 1441 953706 1-592 15-606 AL133071. HTLE543 1442 573403 1-203 15-217 HTLE554 1443 574884 1-312 15-326 AI207997, and AW172597. HTLET56 1444 911654 1-1096 15-1110 AI968198, AI655275, AA397903, AL044119, AW003563, AL044118, and Z74696. HTLET78 1445 836820 1-812 15-826 AL041695, AA454137, T19069, D31497, and AL133566. HTLET93 1446 573454 1-99 15-113 HTLEV33 1447 527956 1-261 15-275 AI808336, AW013835, AI624717, and AI650408. HTLEV95 1448 883332 1-574 15-588 AA776758, AI808140, AA884694, AA909615, AA904970, AA909196, AW294544, AA723919, and AI525608. HTLEW12 1449 870255 1-334 15-348 R02814. HTLEW21 1450 573458 1-311 15-325 AL122083. HTLEY11 1451 967309 1-336 15-350 HTLEY91 1452 775310 1-212 15-226 AC005343. HTLEZ14 1453 791662 1-322 15-336 AC000097, AC006547, AP000344, and AC006549. HTLEZ15 1454 934288 1-368 15-382 D51002, AI541205, AI541321, AI557082, AI535660, AI557238, AI557258, AI557602, AI525500, Z33559, T18597, AI557533, AI557731, AI525556, AI557262, H65400, AI557234, AI525757, C14322, D50992, AI525856, AI557241, AI541027, AI525852, AI535639, AA058620, AI540903, AI541365, AI557084, AI541048, N71206, AI557312, AI526078, AI557474, AI525302, Z33585, AI541075, AI541034, AI541346, AI541353, AI541154, AI557039, AI557041, AI557222, AI557317, AI525656, AI546829, AI536070, AI535813, AI525666, AI541056, AI535994, AF025310, Z30183, U45328, AR050070, U94592, A82595, A82593, A63903, A62298, and A62300. HTLEZ32 1455 870261 1-512 15-526 AC005899. HTLFA74 1456 934172 1-695 15-709 AA398001, AA399683, AW177623, AA809773, and AL137531. HTLFC20 1457 917128 1-1029 15-1043 AA356490, R05624, AA262044, and AL138430. HTLFE01 1458 917033 1-591 15-605 HTLFE05 1459 954984 1-1305 15-1319 AW275845, AI830267, AI572906, AI439086, AA766499, AA723111, AA836614, AA453028, AA747738, AA483838, AA077798, AA077483, AW302599, AA215573, AA077013, AA009576, AA078283, AA323484, AA077510, AJ007798, and AC005071. HTLFE20 1460 934278 1-463 15-477 AC006237. HTLFI28 1461 775392 1-423 15-437 AC003963. HTLFJ39 1462 953730 1-616 15-630 AF053356, and AF174604. HTLFI83 1463 781303 1-501 15-515 AL117491, AB007913, AL137693, and AL110281. HTLFJ39 1464 573462 1-329 15-343 AI001797, and AI910520. HTLGD25 1465 870136 1-1477 15-1491 AA608970, and AA758832. HTLGD69 1466 835493 1-1010 15-1024 AA403179, AA398239, AW339857, and AA952990. HTLGG36 1467 789656 1-561 15-575 AW269804, AA781852, AW104592, AI239999, AI698249, and AC005821. HTLGK55 1468 868309 1-470 15-484 AW393087, R16949, R75708, H44330, AA186786, AA259086, R55419, AA329264, AA335735, AA329538, AA393356, AA354448, W93021, AA136776, T35806, T10451, R46300, R54656, R10335, AA076725, W51754, AL137358, and AL050110. HTLGM02 1469 964878 1-752 15-766 C02944, C03248, AI807681, AA095819, AI797565, AI333238, AI863457, H53759, AW138808, AW451889, AW138004, AW207397, AW184023, and AC005216. HTLGM07 1470 952254 1-1194 15-1208 AI693474, AL042395, AL041671, AW168041, AI738586, AA504349, AI125391, AI990015, AA838043, AI149664, AL041569, AI864457, AA579771, AW273185, AW294188, AW197733, AI805280, AA383594, AI699335, AI138789, AI653680, AI738485, AA383400, AI475427, AA976749, AI203057, AA883961, AI968077, AF096834, AF073954, AF073955, AC003688, and L07578. HTLGT62 1471 918606 1-533 15-547 AL040693. HTLGW17 1472 958208 1-794 15-808 HTLGX90 1473 870528 1-1358 15-1372 AA399144, AI982647, AA394141, AA234366, AA405404, AA034080, AA644012, AA234434, T86343, AI344623, R02436, T86344, AA707052, R02333, and Z98257. HTLHC14 1474 908428 1-752 15-766 AI738485, AI738586, AF096834, AC003688, AF073955, and AF073954. HTLHE72 1475 963471 1-494 15-508 AL078621, Z63130, and Z63232. HTLHL52 1476 958334 1-1159 15-1173 AA459835, AI286187, AA742548, AI187289, AI392611, AA922025, AI138515, AA884337 and AI936608. HTLHO94 1477 968685 1-460 15-474 AI632413, AA026276, AA382241, AA936327, AI026815, AA382375, AA026275, AA860376, and AC006445. HTLHP32 1478 933335 1-615 15-629 AW405738, AA116025, AA102802, AA211814, D63260, AA306027, H97316, T78952, X93817, AW136521, AI659011, AW382734, AW374638, AL022316, Z93241, and AF151854. HTLHP52 1479 926980 1-569 15-583 HTLHP80 1480 870156 1-590 15-604 AA483387, AA065093, AA126035, AA126051, AI871722, AA164944, AA199708, AL044904, Z69651, AP000337, and AC002425. HTLHT15 1481 946586 1-560 15-574 T85616. HTLHT24 1482 870254 1-1191 15-1205 AA402128. HTLHU04 1483 926950 1-998 15-1012 AI869974, AA405686, AI199718, AI969027, AW086198, AL045468, AW082694, AA399273, AW136449, AI933024, AA412383, AA300675, AA405951, AA412243, AL045467, AI150480, AA889135, and AI217882. HTLHV67 1484 936139 1-735 15-749 H44302, R50303, AA341701, AA179217, T60490, AA478857, R47809, AA234882, AA302994, AI797287, F12041, T66192, H81762, AW403784, AA171826, AI417037, AI906347, AI436806, AA298718, AI906396, and AF005038. HTLHZ08 1485 958321 1-663 15-677 HTLHZ10 1486 963475 1-677 15-691 AC005971. HTLIA92 1487 784817 1-723 15-737 AA382329, and T27180. HTLID36 1488 945891 1-521 15-535 AC003662. HTLIK11 1489 966043 1-471 15-485 HTLIP19 1490 958351 1-941 15-955 AA431834, AA412657, AA399262, AI970493, AI026627, AA412489, AA431430, AA383405, AL042749, and AI696044. HTLIQ09 1491 931046 1-630 15-644 HTLIR30 1492 870115 1-709 15-723 HTLIU76 1493 946300 1-829 15-843 AA393092, AA453482, AF012388, and AF002992. HTLIV78 1494 947234 1-685 15-699 AA846864, AI125243, AA446154, AW003474, AI200764, AW137061, AA992083, AI139618, AA429664, AA991813, AA923010, AI150169, AI825677, AI917106, AA429514, AW029457, AW264822, AI800160, AW085654, AI445992, AI660211, AA761545, AW084368, AI633009, AA113768, AI863191, AL048875, AW117746, AI874189, AI583982, AI634707, AW149869, AI537989, AI140134, AI680138, AL035460, and AF185576. HTLIY52 1495 942161 1-1354 15-1368 AI827749, AI819667, AI580407, AI025487, AI223109, AI150036, AW087713, AI024234, T18864, AI479322, AA883975, AW341589, AA860213, AI831802, AA913074, AA608857, AI050685, AA860223, AA948538, and AI075930. HTLJA23 1496 953729 1-943 15-957 AF053356, AF174604, and AF083655. HTLJA24 1497 934279 1-560 15-574 AC006237. HTLJC71 1498 922923 1-1738 15-1752 AL039539, AL045443, AI336919, AA406128, AA405229, AL042307, AA431504, AA311249, AW086440, AA813520, AI240644, AA897733, AW268487, AA782009, AW172455, AI301209, AI014598, AA969918, AL041043, AA431178, AL039540, AA973051, AI221826, AL133030, AC009516, AP000552, AP000556, AP000557, and AL117509. HTLJD35 1499 967336 1-518 15-532 HTLJD88 1500 953714 1-865 15-879 AL041339, AF025310, and AF200923. HTLJJ75 1501 924755 1-1137 15-1151 AA889705, AA224167, AW263624, AI627392, AA907369, AA224175, H41231, AI392654, AI223199, AI208705, AI825010, AL033527, and Z66397. HTLJL23 1502 922994 1-1787 15-1801 W02882, AI017323, AW118900, AA912672, AI208003, AA909041, AI765407, AI765419, AA609441, Z33510, AI016233, AI657083, AI339208, AI991437, AA781685, AA860425, AA382780, Z21333, AA357733, Z21332, AA256011, N74515, AL031587, and AF006501. HTTAD55 1503 835652 1-246 15-260 AA301270, AA301379, and AA301366. HTTAE49 1504 723331 1-269 15-283 AA301335, AA301157, W27731, AA525760, AA449997, AW088581, F07155, AW337237, AI536857, AI524371, AA737106, AA056569, AA491298, AA953587, AI857836, AA515753, AW080777, AA491681, AI766408, AI278972, T39494, R97104, N55508, AI376747, AW081296, AI311647, AT923333, AI207465, F08230, AA531412, AI183976, AA601355, AA953228, AA165505, N73610, AA598927, N72717, AI620992, H72530, AA9709674 AI809745, AI923052, AI674840, AI34 1654, AA648942, T07769, H84675, AA602727, AI950671, H70076, AI270675, R49657, AI908093, AL021939, AL022238, AC004526, AC007546, AL121748, Z98051, AC005368, Z83846, AC004000, L78810, AL021368, AC004447, AL031667, AL049552, AF059650, AL008707, AC004833, AL049745, AC006344, AC006387, AL034419, Z98884, AC004805, AC004996, AL022326, AL035046, AP000080, M31061, M33764, X16277, M81740, U73636, AL031668, AL121658, AC006271, AL133382, AC009286, AC003041, AC007461, AL031587, Z98742, AC005953, AP000557, D87009, AL031311, AC002312, AP000023, AC002350, AL137100, AL022721, AC007051, U07562, AC010209, AC006160, AC007919, AL118510, AC007559, M97911, AC007564, AC004799, AC005067, AC002369, AC005227, AC008122, AL096763, Z95116, AC004947, AC004841, AC003049, AC004655, AC004838, Z85986, AP001053, AC005962, AC008015, AL035086, AC004098, AC005384, AC006115, AC009405, AC006239, AC003684, AP000171, AP000056, AC004477, AC007934, AC003669, AL035078, Z75888, AL049589, AP000967, AC004757, AF106564, U47924, AL078472, AC003038, AC004686, AC004966, AL050318, AC005803, AC005726, AC004228, AC006449, AC004492, AC003091, AC005179, AC004905, AC006552, AF200465, AL049835, AL080242, AL035682, AC005230, AC005484, Z92547, AL031283, AL049759, AL009181, AC004938, AC004008, AF030453, Z98946, AC005088, AC007014, U91318, Z98304, AL133245, AP000556, AB020871, AL031845, AL023575, AC005212, AC005857, AL035530, AP000467, AL031864, AL034417, AP000563, AP000211, AP000133, AL022330, AC003093, AL035417, AC005043, AC004032, AL049646, AC005180, Z75887, AC005251, AC004895, AL049554, AC006130, AL031056, AP000330, AC006270, AC006101, AC005884, Z83856, AP000257, and AP000256. HTTAH87 1505 509574 1-304 15-318 AA301200. HTTAJ35 1506 707750 1-560 15-574 AA460110, AA279729, AA291197, AA301139, T06789, AW295422, AI700465, AA845564, and AI291478. HTTAJ50 1507 509657 1-249 15-263 AA300966, and AA301128. HTTAN57 1508 509453 1-292 15-306 AA300600, and AA301000. HTTA596 1509 961057 1-247 15-261 AA300802, AA300767, and AC004559. HTTAU82 1510 797726 1-296 15-310 AA300687, AA286758, AL139165, and Z70227. HTTBE25 1511 509128 1-256 15-270 AA300493, AA300591, AF059569, and AL049778. HTTBH34 1512 530565 1-313 15-327 Z42096. HTTBH41 1513 530562 1-252 15-266 HTTBH54 1514 530563 1-302 15-316 HTTBJ94 1515 530564 1-311 15-325 AL046237, and AL045777. HTTBN67 1516 578085 1-163 15-177 HTTCAI5 1517 869705 1-413 15-427 AC005833. HTTCD03 1518 925390 1-378 15-392 HTTCD71 1519 530393 1-112 15-126 AL049844. HTTCL35 1520 529672 1-239 15-253 AA505142. HTTCT34 1521 973210 1-1295 15-1309 AW192348, AA081773, H06122, C75208, W38676, AA302953, AI907561, AA311414, AA151050, AW411262, AA226372, AA297279, T50005, AA938031, AI276055, AI433141, AI814125, AA689289, AI264581, AI650824, AW235148, AI273243, AA340545, T50069, AW340759, AW088730, AI093394, W44759, W73928, AI242558, AI800707, AA421100, AA243847, AW265034, AA226593, AW294446, AI097360, AI302409, AI298574, AA770396, AI418623, AA122285, AI150958, R31691, AI969750, AI168830, AW236726, AI459694, AA936951, AA422134, AA150960, AA029400, AW305179, AA046886, AA226401, AI935787, AW118839, R24074, AI803011, AI564140, AI797634, AI671022, AA084054, AA031539, AI831233, AA046979, H79028, H05830, AA033515, AW296225, N70304, R31733, AW296783, H28027, AA334000, F32723, H54170, AA031538, AI826552, AA421099, AA766234, D60652, AI696661, AA913310, AW383613, AI077484, AW383609, AW236130, AA652326, AI191597, H77423, AI435580, AI302073, AI675809, H54014, AI973084, AW383535, AW239479, AA496314, AI971370, AA233111, and AA629153. HTTDF50 1522 526385 1-293 15-307 AA301144. HTTDF90 1523 917155 1-427 15-441 AW052029. HTTDG36 1524 968131 1-347 15-361 HTTDI21 1525 869686 1-341 15-355 HTTDJ65 1526 973307 1-406 15-420 AC006030, AP000513, AB023052, and AC006140. HTTDL38 1527 573641 1-289 15-303 HTTDL45 1528 523452 1-291 15-305 AW292800, and AC007390. HTTDL89 1529 959837 1-328 15-342 W22023, AC004765, and AB002342. HTTDN40 1530 734318 1-373 15-387 AA182963, W39759, AA132990, H69405, R94355, T66121, H68623, H68650, N36314, R14722, AA166770, R70624, AA923755, AW385783, R69735, AA190899, R19750, T10743, H07954, H93885, AA164319, and AC005876. HTTDN85 1531 783444 1-435 15-449 AL137653. HTTDO19 1532 908937 1-320 15-334 HTTDO37 1533 573685 1-431 15-445 HTTDR91 1534 790336 1-549 15-563 AA252780, T84947, and AC005740. HTTDR92 1535 573666 1-326 15-340 AC003046, AC002366, and AC003685. HTTD502 1536 920589 1-418 15-432 HTTDX84 1537 921100 1-668 15-682 AA432195, AA435548, and AA431175. HTTDZ54 1538 692608 1-286 15-300 AW163244, H89834, W06845, N42782, N42829, N31946, and AI190785. HTTDZ91 1539 523206 1-300 15-314 AI762137, AW242639, AA044752, AA884207, AA235512, AI870472, D80100, D59403, W88874, AA481286, N92013, D31111, D31113, AI167596, R10048, AA906542, AW087683, R49500, AI361492, AF155112, and AL137478. HTTEB33 1540 573719 1-336 15-350 HTTEH58 1541 747943 1-307 15-321 HTTEL50 1542 745985 1-196 15-210 HTTEU68 1543 967819 1-1207 15-1221 AA134604, AA187575, T75572, AA083163, W42892, AI092672, T97891, Z44468, R34642, R14267, AI078644, AA354837, R48102, AA362636, R55924, AA497072, AW044159, AW377397, R17450, T78498, AA625142, R56338, AA258076, and R99732. HTTEV62 1544 573614 1-272 15-286 AI828837, AI015418, and AA953392. HTTEY64 1545 974107 1-450 15-464 HTTEY67 1546 917903 1-1523 15-1537 AI869330, AW295435, AI208233, AA447451, AA844516, AA664002, N40294, W04890, AI925298, AA903925, AA447450, AW243978, H14692, H14587, AA360639, and AA732693. HTTEZ34 1547 771602 1-498 15-512 HTTFA16 1548 870198 1-394 15-408 AA160412, and D78751. HTTFB60 1549 869666 1-208 15-222 AW298813. HTTFG35 1550 778426 1-254 15-268 AA581033. HTTFG83 1551 974284 1-698 15-712 AA063114. HTTFH70 1552 757358 1-342 15-356 H64973, AA659316, AA649530, AI636734, AA047057, AA664924, AA157876, AA046906, AI940546, AW028376, H57802, AA420703, AI306717, AA019793, AA385652, AA359194, AA713538, AA713930, AA639056, AA837006, AI679759, AA135988, AA084148, AW019964, AA908682, W27084, AA602458, AA083850, AI679486, C75332, H62123, AA338238, AA055647, W85818, AI634466, AI890283, AC003973, AC006263, AF196971, AC007793, AF039907, U80017, AL049779, AC006530, AL022238, Z83820, AP000221, AL136295, AF011889, AP000084, AL049709, AC006142, AF109907, AL022721, AC004617, AL049780, AL049831, AL020997, AC004462, AC006211, AL049761, Z83826, AL031255, AL024498, AL133216, AC005529, AC006030, AC000134, AC004999, AC004934, AC007390, AL139054, AF111167, AC002314, U85195, AL109758, I59642, L77570, AC005346, AC002492, Z83822, AC006261, AE000658, L39891, AC007993, AC006064, AC005969, AC006950, U91327, AC007664, AL049759, Z97180, Z98949, AC007462, AC005484, AF045555, AC005821, AC006581, AC004659, AC002039, AP000355, AL035684, AC007157, AP000552, AC012099, AF001549, AL022316, AC006162, Z98044, AC005874, AF134471, AC005179, AC005527, AC007688, AC003086, AL049697, AL109984, AL078584, AP000550, AL049760, AC006023, AC004996, AP000692, AC001231, AC007022, AC002040, AC009288, AC007066, AC004876, AC005730, AC008018, AC005320, AL022394, Z82198, AC004148, Z75890, AL023281, AC005037, AC008039, AC006273, AC005516, AC009248, AP000299, AL079342, AC007684, AB023049, AC005031, AC004686, AC002366, AL022398, AC004019, AC006960, AC006417, AC003048, AL031577, AF038458, AC006079, Z81364, D87675, AC002310, AC005740, AC004913, AL096701, AC003071, AC000003, AC004491, AC005744, AL035587, AC004253, AL050307, AC005180, AC001478, AL117351, AC004890, AL031848, AC006241, Z98051, AC003982, AP000114, AC005722, Z97056, AL031432, AL050318, AC006538, AC005089, AC004750, AL049713, AC002070, AL096761, AP000353, and AL133163. HTTFK90 1553 787599 1-551 15-565 AI637920, AI657055, AA772352, AW316972, AI676064, AA904483, T11417, D59503, D81111, D80014, D58283, D58246, D80258, D80043, C14227, D80064, D80247, AA809122, D80251, C06015, AI535686, D80253, D58101, D59502, AA514184, C03092, C14407, D80366, AI557751, D80522, D80022, C14331, H67866, C14389, D50995, D59610, D51423, H67854, D80157, D80439, AA305578, D59859, D80166, C14014, F13647, D80195, D59467, D59619, D51022, D80210, D51799, D80391, D80164, D59275, D80240, D80038, D59787, D80227, AA305409, D80188, C14344, D81030, D45260, D80248, D50979, D81026, D80269, AW178893, D80212, D80268, D80196, D80219, D51759, D80241, D59927, D80024, C15076, AI557774, D51060, D57483, D59889, D80193, D80133, D80045, D80168, AA514186, AA514188, D60010, D80302, D51103, D80378, C14429, D59317, AW177440, C14298, C14973, C14957, D59627, D59653, AW360834, T03116, D51213, D51221, D59474, AI525917, C14046, C16955, AW360817, AI525920, AW377671, AW375405, AW360811, AI525235, D60214, C05695, C75259, D59551, D52291, AW178907, AI525227, AW178908, D59373, AW178906, AW378533, D45273, AI535959, AW360844, AI525923, AA285331, T03269, AW179328, D51079, D59695, D80949, T48593, AW375406, AW378534, AW179332, AW360841, AW377672, AW179023, AW178905, AW366296, AW177731, AI525912, AI525215, AW378528, AW178762, AW179019, AI525242, AW352170, AW378532, Z33452, T02974, AW352120, AW352117, AI525925, T03048, AW178914, AW378539, AW378542, Z21582, AW367950, AW360855, AW176467, C05763, AW378525, D80228, AW179020, AW378540, AW377676, AW352171, AW178774, AW177733, AW179024, AW179018, AW378543, AI525237, AW177505, AW178781, H67858, D51250, AW352163, D51053, C04682, AW177456, C13958, AW178911, C14077, AI525222, AW178775, T02868, AW178909, F13796, AW179004, AW179329, AW178980, AW177728, AW178986, AW178754, AW369651, AW352158, Z30160, AI535961, D31458, AW177734, AA305720, AI910186, N66429, AW177508, T11191, AW179009, AW179012, AW177497, AW177722, AI525928, AI525216, AI525228, D80654, AB028859, AJ132110, AF058696, A62300, AR018138, AR008278, A84916, A62298, A82595, AR060385, AR054175, I14842, AB002449, I50126, I50132, I50128, I50133, A70867, AR008277, AR008281, AR062872, AR016808, AR016514, X64588, X67155, Y17187, AR060138, A45456, Y17188, A94995, D26022, A26615, AR052274, A43192, Y12724, A63261, A43190, AR038669, A25909, A64136, A68321, AR066488, Y09669, AR066487, A67220, D89785, A78862, D34614, A30438, I79511, AR008443, X68127, AF123263, AR016691, AR016690, U46128, D88547, AR032065, D50010, AR008408, and AR060133. HTTFL89 1554 974346 1-405 15-419 AC005551. HTTFM17 1555 750942 1-430 15-444 AI457366, and AI023804. HTTFM66 1556 950051 1-1145 15-1159 AA085574, AA490803, AA147472, AI239866, and AL049745. HTTF559 1557 825922 1-842 15-856 AA228367, AA176965, AA228376, AA004521, AA251249, R00504, AA303183, AW136898, AA448887, R00605, AA229970, H50956, AA345572, AA040486, AA004604, AA177117, AW247896, T74926, AA566080, and AF045584. HTTFT08 1558 934460 1-441 15-455 HTTFV93 1559 925544 1-393 15-407 AA301328, and H78684. HTTFW03 1560 923105 1-459 15-473 AC006566. HTTFX21 1561 924775 1-580 15-594 AI632236, AI279533, AI339379, AI806232, AA401419, AI356680, AW051296, AI096764, AA401395, AW008336, AI419077, AI423753, AI276550, AI435531, AW205745, AW104726, R60187, AI081767, AA830892, AI917002, AI806411, W03327, AW134602, H72137, H71911, H66942, H79399, AA507360, H66943, H81492, AA847135, H71435, H71434, AI824610, AI652697, AA829202, H72050, N32176, H71912, AA507323, H79288, R83711, AA886536, and AI652883. HTTFZ70 1562 974066 1-357 15-371 HTTHH05 1563 931004 1-592 15-606 AC004067. HTTHU43 1564 953479 1-1053 15-1067 AI278633, AA423847, AI276946, AI291687, AA262654, H22961, and AA255728. HTTIG04 1565 926752 1-390 15-404 HTIIH23 1566 869636 1-472 15-486 AW401826, AW408670, AA488824, and AB020677. HTTIH80 1567 869635 1-328 15-342 AC006443. HTTIL06 1568 934089 1-765 15-779 Z25007, AI758350, D80247, D50979, AA305578, C14389, D59275, D52291, D80195, D59502, D80164, D80193, D80439, D59467, D58283, AI525903, D80227, D81026, D80269, D59859, C15076, D80022, D51799, C14331, D80166, D80248, D80253, D81030, D59695, D51423, D59619, D80043, D80210, D80391, D80240, D80366, D80038, D59787, AA305409, C14014, D80212, D80188, D80196, D51022, D80045, D80522, D57483, D80219, D59627, D59927, H67858, D50995, D59610, AI525922, D51060, AA514188, D59889, D80024, D80302, D80268, D80133, D80378, D80251, D80168, D59474, D51103, C14298, AA514186, D80241, Z21582, D59317, D51213, D80157, T03116, D80258, AA809122, C75259, D80064, D31458, D59503, D45273, D59551, D59373, C06015, AI525914, F13647, H67854, C05695, C16955, T02974, C14077, T11417, T03048, H67866, D58246, AI525912, C03092, D80014, C14407, C14973, Z33452, C14227, T02868, AI535686, C14344, D52317, C13958, D51221, D81111, AI525907, C14957, Z30160, C14046, D51759, D59653, D45260, D58101, AI525242, AJ557774, D60010, AI557751, AI525227, D51053, AI525235, AI525920, AI525917, N66429, AI525923, AA514184, AI525215, AI525216, AI525228, AI525238, AI525925, AI525237, AI525222, AI525969, AI535961, AR016808, AB028859, A84916, AJ132110, A62298, A62300, A82595, AR060385, AR008278, AR018138, AF058696, AB002449, X64588, I82448, I79511, I14842, AR054175, AR008277, AR008281, and AR060382. HTTIN23 1569 869634 1-539 15-553 AC002549. HTTIU05 1570 931015 1-573 15-587 HTTIW81 1571 922817 1-434 15-448 HTTIZ05 1572 930994 1-418 15-432 HTTJA11 1573 839725 1-406 15-420 AI522185, and AI889003. HTTJA47 1574 869618 1-417 15-431 HTTJH13 1575 869615 1-297 15-311 AC004859. HTTJM01 1576 913799 1-271 15-285 HTTJQ06 1577 934130 1-397 15-411 AL046690, AL046714, AA301225, AW405562, AC005027, AL132774, AC005050, AC004409, AC006059, AC007785, AC004673, Z99496, AL033397, and AC002488. HTTJX68 1578 974063 1-375 15-389 HTTJY08 1579 958170 1-430 15-444 AL023584. HTTKD44 1580 948750 1-434 15-448 AA300492, R69716, AA377913, AA096018, and AC003688. HTTKF89 1581 960928 1-411 15-425 AA301180, AA300961, and AL035425. HTTKG34 1582 915033 1-378 15-392 HTTKK06 1583 974311 1-584 15-598 HTTKL80 1584 974316 1-464 15-478 HTTKN21 1585 974310 1-504 15-518 HTTKN30 1586 920893 1-487 15-501 N24270, AA355038, W16809, W76580, AA442492, AA394009, AI061614, AA306378, AW327292, N39773, AA431265, AA022944, W16892, H69650, W16816, N95146, AA437055, AA333960, N42264, AA471293, N39663, AA429690, AA287514, N28024, AA336844, AA337096, AA442618, AW298810, T81379, W20041, N25823, AA282421, AA181314, AI038286, AA902825, AI093178, AI128035, AA092603, AI290898, D62144, N26891, AA846456, AA838697, AA640163, N40080, AA758626, W16976, AA939313, AW151976, N56324, AA927961, AI582147, AI223403, AA659796, AI348195, N26593, AA806403, AW118695, AA435600, AI187055, H60112, H98703, and AA022924. HTTKP07 1587 911390 1-562 15-576 AI640500, AA035703, AF130247, and AF165138. HTTK513 1588 926795 1-470 15-484 HTTKV17 1589 830008 1-416 15-430 AC005027, HUDAM29 1590 529157 1-214 15-228 HUDBZ78 1591 739638 1-366 15-380 AI799013, AW173341, AW072440, AI910986, AA620943, AA977595, AA913759, AI208578, and H56769. HUKAA62 1592 503626 1-294 15-308 AA303037. HUKAB80 1593 503445 1-335 15-349 AA300169, AA776941, and AC005841. HUKAC72 1594 966804 1-296 15-310 AA300183, AW419202, H38334, AI124650, AA324325, H38499, AA299557, AA299817, AA663855, and M27444. HUKAM82 1595 954420 1-309 15-323 AA299772, AA299548, and AA299549. HUKAX07 1596 954359 1-258 15-272 AA299237, and AA299353. HUKCC86 1597 529727 1-212 15-226 HUKDH25 1598 531165 1-371 15-385 AC006055. HUKDH50 1599 531163 1-315 15-329 AF064478, AB015355, AL034351, AC007529, AC005723, AC007684, AL020989, AC004448, AL008639, and AC002525. HUKEH36 1600 531110 1-334 15-348 HUKEH50 1601 531108 1-240 15-254 AI743421, AI807422, AI684708, AW104143, AA973066, AA843771, AA846889, AW135078, AI686018, and Z63492. HUKEK55 1602 522213 1-546 15-560 AI085258, AA594171, AA731743, AA252492, AI866553, AW163561, AI028019, AA908826, AI479934, AI292039, AI701571, T32954, AI563944, AA987496, N91123, AA913053, AA748877, AA897110, T03349, AA903350, AA300185, AI268110, AA910894, AI199050, AI702521, T30992, D56255, R56442, Z45121, AA889837, W19847, AI559757, AW245526, AA905779, AA243398, AI871013, AL136295, and AF006264. HUKEO55 1603 714187 1-340 15-354 AI249880, AI312131, AI377805, AL080243, U63630, AC005722, AL023653, AL109865, AC004805, AC006146, AL022162, AC004675, AF088219, AC001226, AC007216, AC002472, AB001523, AC005568, AL049872, AL022324, AL034420, U95742, AL034548, AF053356, AC006084, AL049779, AC005231, AL121825, AC005939, and AC004955. HUKES11 1604 967604 1-168 15-182 HUKFL69 1605 526819 1-352 15-366 HUKFV41 1606 537530 1-289 15-303 AI830434. HUKFX63 1607 946931 1-98 15-112 HUNAD94 1608 575299 1-310 15-324 AA297031, AA298863, AA371410, AA837771, D51877, AI885465, AA077619, AA385775, AA297006, AW243808, F35684, T03928, H47368, AA599080, H79586, AA678472, AA632720, R83068, R92640, H85808, AW275432, AI223626, D51809, AI751191, AW028179, AA653291, AA187760, AI190648, H71738, AI525789, AI193417, AA584594, AI251034, AI254770, AI284543, AI054090, W39287, AI246061, H47736, AA445951, AI753365, R83708, H86399, AI510801, AI251284, AI251203, AI249853, AA788592, AI250552, AI985795, AW381198, AW381196, AL133238, AC008012, AC007363, U91325, AC004890, AL022394, AC002395, Z69733, AC004025, AL133249, AC005969, AC004865, Z99128, AC006197, AC008041, AC007666, AL118497, Z98880, AP000152, AC008033, AF049895, AC000052, AC007919, AP000567, AC004019, AL035454, AC000062, AL079342, AC002457, AC005740, Z82194, AC008123, AC002994, AL031311, U80460, AL122023, AL031114, AC007388, AF146191, AL035089, AC004081, AL049633, AF196969, AC006120, AL049843, AC009411, AL009175, AL135960, AJ131016, AL032821, AC007022, Z97832, AL109653, AL033403, AL022726, AL022151, AL117339, AC007551, AC004979, AC005722, AC005828, U96409, AL022319, AB001523, AC007312, AC007023, AL121825, AL031663, AC008009, AC000353, AC006928, AC002429, AC005509, AL022578, AC004802, AL020997, AL022718, AC006515, AC004020, AC005908, AL133244, AC006317, AC006039, AL049830, U85195, AC004746, Z93930, AL133312, AC007372, and AE000658. HUVBB90 1609 503042 1-330 15-344 AA296418, AA296426, AA302599, AI223784, AI792577, AC005280, AC002287, AC004517, AL031592, AC000353, AL109847, AL034419, AC004993, AC004882, AL079342, AC005529, and Y15000. HUVBB93 1610 502903 1-266 15-280 AA296425, and AL121603. HUVBC12 1611 933023 1-353 15-367 AA296246, AA296176, and AA296416. HUVCQ07 1612 928053 1-358 15-372 HUVCQ55 1613 868795 1-372 15-386 AA296238. HUVCS14 1614 914768 1-317 15-331 T84347. HUVCU71 1615 968663 1-266 15-280 AC005410. HUVCW62 1616 535361 1-386 15-400 AA296264. HUVDB28 1617 535006 1-265 15-279 AA714267, and AL078634. HUVDB53 1618 509119 1-339 15-353 AA296198. HUVDC15 1619 921088 1-490 15-504 AL031281. HUVDD09 1620 707061 1-178 15-192 AW378735. HUVDF13 1621 961020 1-297 15-311 HUVDF84 1622 526248 1-339 15-353 AC005319. HUVDF88 1623 522823 1-340 15-354 AB002339. HUVDJ28 1624 530558 1-463 15-477 H29210. HUVDI76 1625 719332 1-286 15-300 HUVDL30 1626 530387 1-96 15-110 AW367572, AW376975, AW376867, AW367596, AI248747, AW449393, and AI367533. HUVD025 1627 679477 1-439 15-453 N80985, and AC004134. HUVDP95 1628 530386 1-150 15-164 HUVD526 1629 958027 1-590 15-604 AA435842, AA398811, and AC004111, HUVDU51 1630 868660 1-279 15-293 AL009183. HUVBD35 1631 430750 1-732 15-746 AA166861, N56640, D59356, AB008681, and AP000500. HUVED54 1632 534783 1-376 15-390 AL035405. HUVED65 1633 527937 1-151 15-165 HUVEN50 1634 530094 1-96 15-110 AF118069. HUVEA55 1635 868779 1-515 15-529 AI460185, and AW270646. HUVFB48 1636 967815 1-330 15-344 AA161447, AI583468, AA715433, AA630672, AW341978, AW021951, AI865278, R65651, AA640053, H63170, AA743445, AI500453, AI253987, AA094320, AA482273, AL046777, AC006121, AP000513, AC002477, AC007308, AL022323, AL022237, AL049760, AF124523, AC005480, AC006480, AC004686, AC007227, AC005015, AC006080, AP000030, AC002375, AC002550, AL021808, AP000023, AP001052, AL133163, AC006530, AL049780, AL035422, AL035252, AC007637, AC007226, AL023284, Z93017, AL031311, AC004217, AL031276, AC002470, AC006511, AC002425, Z85987, AC005280, AF165926, AF001549, AC004098, AC008033, AL031055, AF030453, U95740, AC007066, AL109984, AL137191, AL031295, AC005088, AC005736, AF001552, AC005701, AC004491, AL049871, AF109907, AC006312, AC004890, AJ009610, AC004019, Z84487, AC016027, AC004526, AL133246, AC006115, AP001060, AP000031, AC006057, AC006316, AC006023, AL079304, U95743, AF196970, AC005071, AC007999, AC004887, AC005057, AL031281, AC005484, AC003969, AC005839, AC003101, AC006013, AL021937, AL133448, AC007738, AC004983, AC002531, U82828, AC004782, AC006014, AC002525, AC002073, AC005189, AC006160, AC004859, AC007421, Z83838, AC004998, AP000510, AC002352, AC007277, AC008044, AL031985, AC006501, AC007207, AC004878, AC006111, AC005488, AC002553, AC007384, AC004821, AL024509, AL031053, AC005082, AL079342, AC006130, AC004253, AC004386, AL080243, AC006509, AC007298, AC006450, AC005874, AF134471, AC007225, Z99291, AC006597, AC003029, AC005046, AF001550, AC004675, AC005859, AC005972, AL031427, AC005667, U78027, AC005921, AC010209, AC004000, AF205588, U52111, AC002511, AC005901, AL078581, AL022165, AP000501, AC002558, AL020997, AC004216, AC005006, AC004960, AC005529, AC006040, AC012384, AF088219, AC007444, AP000212, AP000134, AL031431, AP000042, AC004817, AC005823, AE000658, AL121754, AC009501, AL050343, AC005412, Z96811, AC019014, AL109628, AC005619, AC005740, AC004967, AC016830, AC006449, AL133245, AC005696, AC007216, AC006512, AL050318, AC003010, AF129756, AC008149, AL121652, U80017, AC005829, AC008041, AL049830, AF050154, AF107885, AL021707, AF001548, AL135744, AC002302, D87675, and AC005261. HUVFB69 1637 868782 1-558 15-572 AA077619, AI620756, AW068786, AA547979, AI613285, AA613225, AL039761, H57324, AI018726, F33126, AW007980, AA804334, AI732789, AI821355, AA721572, AL037777, AI383965, AI364836, T63368, AW406046, AA558488, N77307, AL038005, AA515733, AA663063, AW029515, H47719, AI557422, R19998, AI376406, AW008161, AI963183, AI624421, AW243945, R97239, AA831638, AI017733, AA017334, AI240919, AI682310, AA862014, AI308598, AA584207, AA032020, AA297789, AA086257, AA493497, AI672931, AA523695, AI053784, AI926656, AW068580, AA599532, R14787, AI694784, AA662905, H22767, R99944, AA565319, R85174, AI816058, AA301899, AA364150, AI472782, AA588353, AA935380, AW029251, AA573051, AA487152, AA225548, AL047645, AA526413, AI581277, AA773042, AI336771, AC003982, AC005412, AC005535, AF042484, AP000045, AL121652, AC005006, AL035413, AP000356, AC005899, AL031984, AC003070, U91321, AL121603, Z84496, AC005730, AC004832, AC006316, AC007637, AJ239325, AL078459, AF196969, AF196972, AC005057, AC007676, L81772, AC002107, AC002106, AC004042, AL050307, AC009247, AC006515, AC004983, Z83838, AC001643, AC002319, AL049743, AL022320, AL035659, AL096791, AL049856, AL049692, AC003037, AL049849, AC002351, AC005225, AC008064, AC002365, X82877, AC006463, AL034417, AF029308, AC007792, AP000333, AL031602, AP000173, AL121655, AC005549, AC004774, AC002299, AC004125, AC002072, AP000066, AC006536, Z82179, AC005519, AC009516, Z99716, AF024534, AC005379, AC004084, AC006006, AC003685, AL034379, AC004671, AC005751, AC007686, AC005071, AL109798, AL031593, AC005625, AC006163, AC003030, AJ239318, AC002126, AF038458, AC005841, AP000114, AP000510, AC004079, AC004263, AL049911, AC005393, AC004841, AL021578, AC007226, AC005828, AC006948, AC005874, AF134471, AC008041, AC007773, AC005500, AC004025, AC002394, U72787, AF015416, Z93023, AL034395, AC002404, AC004933, AC004595, AL030996, AC007790, AC005755, AR003505, AC004019, AC005030, AC004151, Z82217, AC004656, AL021453, Z93930, AC004797, AC004706, AL049759, AC004844, AC005940, AC005924, D87675, AL035455, AB023049, AC004560, AL021397, AC005182, AP000504, AC002558, AL049570, AC007285, AC007671, AF129756, AC004685, AC007546, AC000379, AC001531, AC004765, AC005624, AL050312, AL023582, AC005067, AL078581, Z86090, AC006965, AC006501, AC005666, AL031584, AC005291, AC007748, AC004033, AL050012, and AF001550. HUVFC07 1638 952080 1-474 15-488 AI338539. HUVFH03 1639 922064 1-350 15-364 HUVFH32 1640 934003 1-316 15-330 HUVFI03 1641 868776 1-162 15-176 HUVFK11 1642 965765 1-425 15-439 AA449997, AI653493, AA654979, AI828405, AI275183, AW242031, AI754037, AA297496, AA557982, AI471691, H90844, AA501554, AI291124, AI146750, AI821881, AI821918, AA640430, AC004797, AL050318, AC007283, AC005274, AC004150, AC006449, AL031295, AC005412, AP000692, AC006509, AL031427, AC004148, AC005233, AC004098, AL050348, AC006111, AC005015, AC000025, Z93023, AL109627, AC000041, AC007191, AF053356, AC002563, AL031729, AL009181, AC004645, AL049539, AL035458, AC005969, AC007225, AC005907, AL008718, AC004531, AC004675, AL133448, AF181897, AC004966, AC003026, AL117352, AL096701, AC005940, AL121653, AL022476, AP001053, AL008630, AC006241, AP000052, AC005736, AC004647, Z83826, AL049697, Z85986, AC006023, AC007536, U91323, AC005527, AC007688, AL020993, AC005578, AF207550, AC005175, Z95115, AC004821, AC005972, AC005632, AC007731, AC006285, AF205588, AL049759, AC007386, AC00550G, AP000344, U63721, AL139054, AP000114, AL049829, AC002059, AL049843, AC002470, AC007308, AC009516, AL117344, AL034400, AC007541, Z99495, AL035249, AC004134, AC004408, AL096791, AC016025, AC002045, AL117337, AJ003147, AC002369, AP001054, AL133396, AC008040, U95740, AC006480, AC006965, AC004073, AL049766, AL031587, AC007395, AC006057, AL049569, AC005519, AC005004, AC002477, AP000689, AC004854, AC007160, AC005529, U47924, AC004913, AL035072, AC004099, AL049650, AC000118, AL031984, AC004895, AC005057, AC005409, AC004814, AL049712, AC007919, L78833, U91326, AC006275, AC004752, AC002350, AC005411, AL049839, Z83844, AF111167, AC008372, AF001552, AC006441, AC007787, AL110502, AC003093, AC006960, AC016830, AC004583, AC006064, AL133485, AL008719, AC004874, U82828, AP001052, AC007193, AC005037, AF200465, AC009509, AC007686, AC004686, AL024498, AB016897, AC002310, AC005031, AL031733, AC003104, AC004791, AC020663, Z95116, AC005261, AF196972, AL117339, AC005377, AC005954, AC007011, AC004491, AL035587, AL022316, AL122020, AL034420, U91321, Z93020, AC002073, AP000167, AC006930, AC006071, AC005288, AC004526, AP000359, AP000967, AL109628, AC004882, AC005772, AC002549, AC007878, AC004084, Z99128, AC005324, AC002418, AC003982, AC007314, AL117694, U91318, AC005237, AC002312, Z68226, AC007421, AC008072, AC005041, AC004876, AL031258, AC005740, AC004922, AF001549, AC005763, AL035460, AP000356, AC016027, AL080243, Z69709, AL121655, U80017, AJ246003, AC006130, AP000131, AC002126, AC004813, Z85987, AC005962, and AP000696. HUVFK58 1643 868784 1-772 15-786 AI797913, AA699643, AI583734, and AA010369. HUVFL71 1644 958059 1-523 15-537 HUVFQ03 1645 922727 1-457 15-471 HUVFR02 1646 918233 1-564 15-578 AA076812, F12628, R10205, AA331552, AI752258, R86677, and T74459. HUVFT28 1647 870617 1-829 15-843 R06515, and AC008116. HUVFT50 1648 868769 1-357 15-371 AW303494, and AB032978. HUVFZ06 1649 933942 1-408 15-422 HUVGZ77 1650 909169 1-370 15-384 AI942325, AI672318, AI672319, and AB011665. HUVHB35 1651 868751 1-342 15-356 AC005683, and AF172277. HUVHB59 1652 963129 1-388 15-402 H98236, and AC005940. HUVHC93 1653 908555 1-404 15-418 AA412491, AA412659, AA669386, T93130, T91516, and AB023189, HUVHD88 1654 868697 1-145 15-159 AA658406, AA584733, AL038606, AW189113, AI524360, AI589230, AC006512, AC002994, AC003663, AC006312, AP000104, AC005907, AL109956, AP000272, AC007242, AC006050, AC005632, AC004675, AP000359, AF088219, U91322, AC003051, and AC005952. HUVHG80 1655 968507 1-375 15-389 AC002076. HUVHI07 1656 952090 1-508 15-522 AA551131. HUVHO40 1657 924621 1-473 15-487 AA120795, AJ003560, AA358990, AW373532, AB014585, AL096767, AC004527, and AC006557. HUVHU74 1658 868649 1-348 15-362 Z98036. HVCAZ38 1659 969208 1-1151 15-1165 AA477501, AA479873, AI003611, AW270619, AI755214, AI754567, AA584489, AI754105, AI783911, AI962030, AA904275, AI620585, AI570943, AA779783, AA262752, AA013168, AW277253, AW438856, AL079734, AA582554, AA535216, AA019973, AI491765, AI872216, AW439703, D26361, AP000493, AC007938, AC004019, AC006210, AC003957, U47924, AF106564, AC005529, AC006077, AL031311, AF038458, AC006312, AC005578, AC000052, AL031680, AC004150, AF196779, AC005694, AC007666, AC005295, AC004895, AC005368, Z93023, AC005755, AC006006, AF053356, AC005682, AC005972, AC005306, Z82172, AC005231, AC005081, AC007435, AC004972, U62293, Z83844, AC004973, Y18000, AF207550, AL035361, AL050306, AC004263, AL121655, AC004686, AC004999, AC004812, AL049766, AL078587, AP000152, AP000502, AC010206, AB015355, Z99755, AP000501, AL121603, AC003006, AL034402, AF111169, AC005225, AC005399, AL034429, AP001053, AC002996, AC007461, AC005224, AC005632, AL049780, Z69917, AC005535, U91321, AF109907, AC007536, Z97183, Z86090, AC004408, AL031602, AC004887, AC004253, AL049697, L44140, AC005520, AL023575, AF134726, AL109657, AP000365, AC007546, AL049776, AC003035, AC004531, AC005264, AB023051, AD000092, U85195, AC006449, AC003663, AC007055, U95090, AC005620, AC005971, AC002126, AC002395, AC006960, AL031121, AC004890, AE000658, AC004707, AC004472, AC004859, AC005619, Y14768, AL022322, AP000512, Z83826, AC004000, AL133448, AL021878, AJ003147, AL009181, AC005089, AC009516, AC007283, AC002404, AC006512, AP000350, AC004131, AC005914, AC005102, AC007308, AC003029, AC020663, AL023803, AC007327, AC002350, AC005245, Z82206, AC006101, AC006111, AL049745, AC004797, AC005701, Z71183, AC005722, AC006509, AC003010, AC006468, AC007690, AC008085, AC006166, AL049643, AC004858, AC000134, Z94801, AC002365, AC005790, AL049539, AC005064, AC007263, AC006120, AP000359, Z85986, AC004966, Z98745, AC009247, AL022345, AC006251, AC005919, AC007707, AL035422, AC004821, AC004974, AC004881, Z99570, AC004929, U80017, AC000159, AC004448, AF027390, AC016025, AC005037, AP000505, AL034421, AL021918, AL136504, AL034420, AC006511, AL031584, AC004905, AL035086, AP000557, AF196972, AC008123, and AC005736. HVCBV04 1660 925844 1-618 15-632 HVCCC81 1661 933449 1-49 15-63 HVCCK04 1662 925796 1-903 15-917 AA130954, AI826639, AA149522, AI625572, AI452441, AI653591, AI305234, AI433556, AI366037, AI076932, W60508, AI298406, AW249838, AA693895, AA932571, AI248312, AW136383, AI420053, AW250502, AI216563, AA678309, AA426066, AA937788, F31582, AA340275, AA204645, R11867, AI570112, AI692968, R60411, AI000109, AA130824, AA207010, W56198, AW382487, AW382451, AW392670, AW372827, AW363220, AW384394, AL119443, Z99396, AL119391, AL119497, U46351, U46349, AL119483, AL119319, U46347, AL119484, AL119363, AL119457, U46346, U46350, AL119324, AL042965, AL119444, AL119355, AL119396, AL119439, U46341, AL119341, AL119335, AL119522, AL119418, AL119464, AR066494, A81671, AR069079, AR060234, AR054110, and AB026436. HVVAC41 1663 949141 1-259 15-273 HVVAJ01 1664 914354 1-479 15-493 HVVAJ06 1665 933675 1-375 15-389 HVVBG19 1666 968967 1-541 15-555 HVVBK45 1667 964102 1-1441 15-1455 AI751508, AW439242, AI858347, AA954665, AW173684, AA639199, AI633169, AW304822, AI828611, AI088904, AI923258, AI635118, AI952782, AI683485, AI635010, AI963627, AI278264, AW129973, AI860650, AI373090, AA642700, AI860395, AI982534, AI637577, AI561081, AW304817, AI167846, AW130866, AA747281, AI984745, AW379208, AI683773, AA587659, AW058417, AI267698, AI986135, AA488133, AI744496, AI684490, AI559255, AA488134, AI887129, AA282616, AI274756, AA730687, AI472334, AI492872, AW150281, AW169998, AA970450, AW055340, AW193022, AI288077, AI955042, AI858187, AA978256, AI189233, AI888974, H01983, AA130169, AA644170, H01972, AI273008, AI273026, F09244, R70971, AW391166, AI873591, AI399762, AI565023, AW189754, AI824564, AI634443, AI275201, AA907212, T96248, T93742, Z39255, AI873453, R70923, F11589, AA918265, AI284207, AI567328, H91570, AI868395, R12808, AA354807, R59470, AI624071, AI611218, R59469, AI636153, AA337310, AI954448, H13229, R32680, AI886562, AI961717, AA255886, AA694475, AA854659, AA256684, D60252, R41517, R28489, AI347373, AI889488, AI309793, AI478725, AA287318, AI691017, AI768787, AI418367, AI819921, H24906, AA634601, H26324, T24624, AI870106, C02323, AI479533, AI983094, AI566584, Z43173, AA629599, Z98172, Z84466, and AC005225. HVVBK72 1668 933167 1-967 15-981 AW367808, AI016826, and AL135700. HVVBV44 1669 917559 1-228 15-242 HVVCO01 1670 913996 1-659 15-673 HWLHJ68 1671 957834 1-1601 15-1615 AW364014, AW364012, AW364015, AW364019, AI760785, AI384093, AI224905, AA282933, AI267509, AA513728, AA729606, R80458, N76465, N59362, AA334630, AA300682, R69849, R80659, AA573139, H86676, AA427982, AI499874, R31977, AJ351352, D61921, AI091339, AA310325, AI051323, AA830587, N67319, AA449856, AA621436, N93060, AW134482, AI694673, AI161320, AI623166, AI582177, AW241458, AA648966, AA724337, and AB033047. HVVDT04 1672 925793 1-286 15-300 AA811233. HVVBY08 1673 957658 1-608 15-622 AA481033, AI352156, AA845263, AA918987, AA534490, AW089740, AI718613, AA845628, AA609823, AI369407, AA631989, AI669939, AI310130, AW007165, AA609822, AI620598, AI310317, AI718649, AI693036, AI168639, AI004446, AI253744, AW081227, AW005641, AI097314, AW235502, AA738077, AI440490, AA481085, AI198174, AA121509, AI018313, AI167316, AA601606, AI092025, AA989671, AA705106, AA402875, AA532756, AA872342, AW081239, AW081228, AA953907, AA215299, AA588197, AW262214, AA975943, AA580166, AW405706, AI915786, AI762484, AI081256, AA927941, AI698971, AA927751, AW009088, AA524140, AI695474, AI364551, AA214505, AA722938, AA923824, AI240069, AA631636, AI468059, AA358257, AA743585, AA382416, AA233136, AA729480, AA595320, AL119399, AL119511, AL119457, AL042544, AL119324, AL042382, AL043152, AL079794, AL043168, AL134524, AL037081, AA865126, AL042866, AL120853, AW051212, AI637584, AI433157, AI702073, AL079741, AI591420, AI493567, AW051088, AW168828, AI590575, AW169132, AI673363, AI610690, AI352497, AI698391, AI889189, AI633125, AI915291, AW152182, AI431323, AI862139, AW078729, AI002285, AI932794, AW173633, AW198090, AW192652, AL121007, AI679672, AL046052, AI697207, AI538564, AL046931, AW090550, AI560679, AI884318, AW268964, AI670009, AW264019, AW075936, AI819326, AW006302, AW051258, AI818683, AI783792, AI612852, AI358213, AW129230, AI610671, AI630877, AI921464, AW080746, AI312542, AI890838, AI040725, AL119791, AI473536, AA748343, AI912356, AW168788, AI571439, AI802542, AI922561, AI815855, AI471429, AI570807, AL037582, AL046595, AI866469, AL037602, AI288050, AI635287, AW026882, AW168031, AI684234, AI559619, AI499963, AI564719, AI951868, AI095119, AI669639, AI890223, AW004886, AI589428, AW169604, AI590021, AI432969, AW078710, AI688858, AW239367, AW079572, AI270183, AI687362, AI499285, AI653979, AI6200 15, AI522052, AI624693, AI470674, AI677796, AL040207, AI619502, AI978703, AA740450, AI923 124, AI682971, AI887396, AW087445, AI284084, AW118417, AI564259, AW148363, AI801+766, AW075669, AW074172, AW088628, AW081298, AI469532, AI872423, AI909661, AI640729, AI283760, AI866770, AW190194, AI679550, AI812015, AI923370, W74529, AI690748, AI613038, AW192687, AI648684, AI539771, AI446809, AI870192, AI538850, AI871697, AI580190, AW129659, AI249877, AI432030, AW083778, AI348914, AI452560, AI926790, AA641818, AI499890, AI890833, AI677646, AI815232, AW081343, AW193020, AI679098, AI241923, AI587606, AW131294, AW167021, AI954183, AW148408, AI799183, AI357940, AA835966, AC005258, AF182293, Z63483, U77594, Y11587, X65873, X60786, L13297, I89947, AL137271, AF177401, L10353, AF061981, AF113694, U00763, AL080159, X52128, A08910, A08909, I48978, AR038854, I30339, I30334, AL137480, AF111851, AF153205, Z82022, AL137459, AL050149, AL050277, AF139986, A77033, A77035, AL137523, A08908, AF031147, Y09972, I46765, A08916, A08913, U35846, AF067790, AE126247, AL049347, AF111112, AR060234, AF031903, AL049430, AF182215, AL137281, I09499, E05822, AL050110, AL117583, AF090886, AL137533, AL050366, 563521, AL137478, U42766, M92439, AI8788, AF000167, A76335, AF183393, E06743, AL137479, X70685, AF151109, AF085809, AR053103, A65341, AL133557, AF026816, AL137463, AL133093, AF001215, AF111849, AL122100, AF090900, AL080148, A08912, AL137539, X98066, I89931, AL049283, AJ000937, AL133075, AL133568, AF104032, I49625, X82434, A18777, AF097996, AL117416, A45787, AF180525, AL133665, S77771, I00734, AL133560, I48979, A57389, AL137526, Y16645, Z37987, U66274, E00617, E00717, E00778, AL133113, AR020905, AF113019, AF113699, AL110221, M27260, U88966, AR066494, AL110158, AJ003118, AF158248, AL110225, AF004162, AL137550, AL137488, AF114168, AF100931, U90884, X84990, AF017790, AL137529, Y14314, AL080156, AF090901, AF030513, AL050138, AL137476, L04849, AL133637, AF067728, AL133558, Y10936, I33392, AF090903, AL096744, U01145, AL117440, AL096751, AL117435, AL133565, AF032666, Z97214, AF081197, AF081195, X76228, AF087943, AF132676, AF069506, AF061836, AL137538, X59414, A93350, AL080129, AF106862, AL110280, E01573, E02319, I22272, A21103, A08907, AL133080, AL117626, AF079763, AL122098, AF185576, AL133606, AF000145, AF162270, A08911, X81464,AF028823, X80340, E02349, AL122111, M96857, S68736, AL050393, U91329, AL137267, AL110218, AF113691, U49434, U67958, AF159615, AF142672, AF017152, U87620, X99717, U80742, AL133031, AJ005690, S76508, S78214, E12747, I89934, AL080124, AL137429, AF113677, X87582, AF118090, AL117460, AF026124, U96683, AL023657, AJ010277, AL122118, AB026128, Y08769, A58524, A58523, AF078844, AL117648, AL122110, AL050170, AR013797, AF076464, AF090934, AF114170, L19437, U92068, X99257, AL133640, Z72491, L30117, AF109155, AL117457, AF036268, X57961, AF057300, AF057299, X83508, AF113690, E03348, AF113689, X66862, AF022813, AR000496, AL137560, AL049382, and U39656. HVVBM06 1674 933528 1-466 15-480 AI685069, AI378607, AI126015, AI129820, AA912338, AI367538, AW192295, AA495868, and AI738723. HUVHL82 1675 912011 1-567 15-581 AI761350, AF039240, AI352375, AI206857, T25311, AW291067, AI090441, T25310, W39573, and AC004596. HUVHI06 1676 952479 1-2268 15-2282 AW188421, AI810011, AW241649,N51726, AA449707, AI275102, N66707, AI299870, AI805173, AA448561, D82294, AW002169, AA523264, AW450305, N33880, AI929539, AI888456, AA912441, N25245, AA909431, H13878, AI362098, H17359, AW020771, AA858024, AA954574, AA012893, H17330, H08372, H08373, N51811, H08249, H40727, AA828659, H08148, Z45445, AA447120, AA828725, AA354903, AA736863, Z41152, AA172308, AA247943, AA581242, AA019451, H13835, AA336350, AA171992, T16753, AA337210, AI160120, AA854342, AA935605, AW086477, AI242421, T49472, AI471813, AI803581, AI301683, AI287719, AI803133, AI752956, AA996171, AI983147, AA136130, AA906744, AW136726, AA482550, AI363029, AA926759, AA448845, AA287077, AA910010, AA885946, AA906319, AA429360, AA969237, AI005339, AL037854, AW246747, AA808249, AI282196, AI276053, AA737505, AW015432, AI872692, AA166813, AW250179, AA773516, AI253632, AA670020, AI368453, AW275936, AA608627, AI263811, AI985149, AA833795, AA879424, AI886945, AL037427, AW026473, N25721, AW183174, AW082723, AL037853, AA553414, AI809312, AI186804, AI005449, AI986314, AI673381, AI017892, N48321, AI919513, AI468411, AA887602, W60356, AA169201, AI445179, AA554323, AA705759, AI686271, AI651379, AI742846, AA533769, AA702089, W45427, AA724285, AI391610, AA824443, AI352069, AI869500, AI420348, AA599184, AA744761, AL037220, AW079854, AA417981, AW337696, AI453528, AA372237, AI095475, AA127848, AI445148, AA581188, D82430, AI363934, AI860112, AA847002, AI743438, AI919040, AI469498, AA577316, H56183, AA640332, T03741, AA897496, T60053, AI827644, AI916823, AA715407, AA833676, AC006238, AF044670, and AF157497. HUVGP05 1677 930892 1-384 15-398 AW293310, AI761633, AA721086, AA488897, H86783, AW296923, AA648257, AA906315, H84926, and AF091457. HUVFP71 1678 950681 1-431 15-445 H15460. HUVFI01 1679 945834 1-1366 15-1380 AA368455, AA861915, AA367693, AI000735, D31762, and AL049611. HUVFE03 1680 922889 1-692 15-706 AA235432. HUVDO18 1681 868783 1-299 15-313 AI003772, AW304257, AI624133, AW149036, W45510, AW328027, AW069137, AA375087, and D84488. HUVDO11 1682 967813 1-263 15-277 HUVDO07 1683 954224 1-301 15-315 HUVDM27 1684 521938 1-342 15-356 AC004954, and AC004084. HUVDH61 1685 526590 1-331 15-345 AA664604, AA568204, AA570740, AA483606, AI446623, AA315361, AL042373, AI569510, H91062, AA449669, W03333, AI801505, N55515, AA603413, AI889579, AI431513, R51582, AI300054, AI253376, AI278089, AW236163, AI356440, AA916177, AA757426, AA130647, AI754170, AI536834, AA513846, AW069412, AA326824, AI627614, T73016, AI284595, AA745470, AA084609, AW406659, AI583106, AI635609, AA401963, AC006129, AJ236701, M87914, S42653, AC006251, AC005368, U62317, AL035587, U96629, AF095725, AC005261, AL080242, AC006468, AC005747, AC005520, AC007283, U80017, AC005585, AL021977, AC007193, AC006449, AC005940, AL022336, AL031283, AC006312, AL031602, AC004999, AC002544, AC002400, AP000240, Z98941, Z94802, AL035458, AC004491, AC006276, Z98051, AL022165, AC005722, AL031311, AJ011930, AC006064, AC003688, AC005484, AC004814, AC006111, AC004757, AC003080, AP000555, AL031848, U62293, AC000353, AC004815, AC004890, AL135744, AC006071, AC005839, U91318, AC002310, AC005531, AC007510, AC005086, AC004922, AC004797, AJ246003, AC006285, AC006126, AL022311, AC006088, U91325, AL031228, AC002996, AC004593, AC000354, AC005412, Z82248, AC002044, Z84466, AC002418, AL121658, Z98742, AC000086, AL049779, AP000065, Z96811, AC005971, Z98304, AC004832, AC005057, AC004386, AF023268, AC002472, U95742, AC002347, AL035659, Z99943, AC005746, AL121653, U50871, AC005702, AP000156, AC005212, AC004659, AC002316, AP001053, AC007292, AL034555, AP000096, AC005519, AC007225, Z84480, AC003109, AL031775, AC007216, AC004881, AJ003147, AF121781, AC002286, AL021453, AL022320, AC007421, AB022537, AC007707, AF064861, S79349, AL079340, AC002366, AP000014, AC006501, AF124523, AC002115, AC002059, U52112, AL031591, AP000696, Z95115, AP000053, AP000121, AC003966, AC006130, AC006343, AC000026, AC005823, U33956, AC004106, AL109827, AC005280, AL080243, AP000251, AC004821, U91326, AP000355, AC009247, AC005031, AC006020, AL022316, AC005480, AL021579, AC005529, AF196972, AC005763, AC007363, AC002314, AC002430, Z97630, AC010582, AL050318, AP000695, AP000553, AC009516, AL035086, AC006039, AC004656, AF045555, AC005190, AC005081, AL020997, AC004983, AC002094, Z97181, Z98749, AC007384, AC004912, AC004963, AC002511, AL049761, AC000378, AF031078, AL031681, Z83826, AC004644, AC004448, AP000353, AL021707, AL049843, AC004531, AC005666, AC007842, U95739, AC000025, Z68128, AF030876, AC002350, AC007263, AL024507, AC004760, AC002073, AP000030, AC005696, AP000501, AC006001, AC016027, AL050321, AC005527, AP000362, Z99716, AC003963, AC003007, AC005014, U07561, AP000356, AL031597, AC004883, AC004699, AP000168, AC005512, AC005089, AL049569, AP000326, AB001523, AC005015, AC005391, and AC006388. HUVCU26 1686 974232 1-688 15-702 AC005342. HUVCM76 1687 522660 1-133 15-147 HUVBC21 1688 671479 1-702 15-716 AI629014, AI015875, AA020867, AA020818, W15455, AI392776, W39642, AI248691, AI022556, AA296410, AA017442, R02316, and AF088026. HUVAA46 1689 667943 1-603 15-617 AA302686, AA302685, AA704009, AA568204, AA570740, AA483606, AI870453, AI720968, AW078909, AA550850, R55078, AA829036, AA719073, AW089322, AA484892, AA488746, AA935409, AI340151, AA676592, AI174456, AA320149, AL035400, AC007221, AC007425, AL020995, AC0050I5, AC007731, AC005500, AC004650, AC007308, AC005274, AC002470, L77570, AC002477, AL133500, AC005696, AC005280, AC012384, AJ251973, AC007055, AL096701, AC005722, AC004067, AC004000, AL109963, AC005088, AL117330, AL133353, AC005740, AC005081, AC002287, AC002070, AP000128, AP000206, U85195, L78810, AL132777, AL022323, AC006160, AC010170, AC005921, U91321, AC004913, AC004382, AP000245, AL132987, AC003108, AE000658, Z93020, U91323, AC004832, AC005919, AL117344, U91322, AB023048, AL031276, AL030996, AC004966, AL050318, AC007676, AC005484, AC006480, U95740, AL121653, AC005529, AC007052, AC004876, AL050332, AC005844, AC005874, AF134471, AC003029, AL031281, AC002302, Z83844, AP000049, AP000116, AF001548, AC002299, AP000553, AC005971, U91326, AL133245, AL121603, AC006344, AC007172, AL021391, AC005527, AL021807, AC005005, AP000311, AL020997, AC002059, AC006538, AL031588, AC002369, AC006511, AL035079, AC006057, AC005071, AC005200, Z95116, AF045555, AC002544, AC006277, AC007637, Z93930, AC002350, AC007546, AC004967, AC004878, AL031594, Z93023, AC006023, AL049569, AL133448, AC004491, U80017, AC005011, AC0050I5, AL033527, AL049761, AL049760, AF190465, AC007011, AB023049, AP000008, AC007934, AL035422, AC005102, AC005821, AC007371, AL109802, Z98051, AP000704, AC005225, AC006208, Z85986, AL035683, AL031289, AC007041, AC005920, AC000052, U62293, AC004531, AP000692, AF196969, AP000121, AC006312, AL034429, AC006254, AF111169, AC007030, AC005906, AF109907, AC005324, AL133382, Z86090, AL049776, AC008018, AL008716, AL022316, AC003663, AP000552, AC004477, AC004883, AC004841, AC002326, AL096706, AL031432, AC005796, AC000353, AC000378, AF053356, AC004953, AL139054, AL117337, AC005399, AL050348, AC005606, AC005231, AC004019, AC005562, AC005335, AC005332, AF047825, AC002559, AC006468, AL122003, AL031279, AP000115, AC006449, AP000031, AC007057, AL031602, AL035405, AL021154, AP001053, AC007225, AC004998, AC005664, AC009516, AC005881, and AC005184. HUNAK12 1690 839574 1-421 15-435 AA757367, AA296644, and AC006327. HUNAG41 1691 711543 1-473 15-487 R19731, H08375, H06407, R54527, AI654477, AA298292, and AI683415. HUNAF22 1692 800452 1-422 15-436 AA298987, and AC006222. HUNAF20 1693 961527 1-467 15-481 AA528216, AI347038, AI308941, AA583432, AA412292, AI147693, AA632915, AA836857, AA018749, AA135185, AA516435, AA916348, AA514541, N62509, AA470014, AI350971, R42401, 1117978, AA299011, AI207239, AA349833, AA494556, F12523, AA290708, and AF184971. HUNAE95 1694 796691 1-411 15-425 R68794, T89302, R64326, R78900, AA299021, AW021631, R26617, and AI820562. HUNAE76 1695 524239 1-308 15-322 AA298749, AW078909, AA742815, AA557686, AC004132, AC008372, AL022238, AC006430, AC005011, AC005899, AC002351, AF001549, AC004821, AL035420, AC006441, M89651, AC005746, AJ003147, AL031276, AC005969, AL009031, AC002326, U91318, AC004837, AC000387, AL034423, Z15025, AC003101, AC005037, AC005184, AC004526, AC018633, AP000215, AL031295, AL008718, and AP000502. HUNAE02 1696 921132 1-429 15-443 AA502008, AA298860, N59191, AI559794, AI218041, AI805928, N59181, AW188364, AA470022, H29622, AI216757, AI015520, AI202594, AA458483, AA565254, AA883777, N89710, AW340697, AI288448, AA588588, AI344556, AI248194, AI469895, AI954555, R89606, AI149444, AA505427, AW118040, AA886990, N30779, AW206450, AI800674, AA343608, AI761704, AA514300, AA581058, and AF151848. HUNAD10 1697 968590 1-479 15-493 AA258009, AA299129, C02926, N85987, AA630672, AI499588, AW023990, AI636730, AW196064, AA380354, AA588001, AI818231, AI745151, AL045808, AL046156, AW341978, AA903253, AA515457, AA308716, AA575911, AA532700, AI494539, AI537772, AL046266, C15060, AA715201, N53062, AA370455, AI524360, AA487621, AI754544, N94065, AA488746, AI355556, N23504, AA480574, R73754, AW081194, AA531580, AL138182, AA618452, W47183, AA580808, AA345064, H69765, F00440, AI684097, AI817516, AA559241, AI908575, AL119724, R43288, AA833896, AA833875, H12383, AA402129, AA502991, AI306232, R65651, AA806762, AA604840, AW089322, AI174891, AI002744, AA463590, AA476397, AA719073, AI623423, H78032, AW085718, AC012627, AL020993, Z93017, AF052041, U78308, AF095725, AL121655, AL049631, Z99128, AL035415, AL035652, AC005377, AF111169, AF003529, AL096766, AJ246003, Z95152, AL009179, AC006353, AL117355, AL121653, AC004655, AC005037, AC006059, AL031279, AL031289 AC004593, AL031282, AC003682, AC005920, AF015720, AL078638, AB019440, AL117351, AC005210, AC002558, AL078581, AC002036, AL022329, AP000269, Z93023, AL034549, AC004383, Z99716, D86992, D88270, AL023096, AC007225, Z98048, AP000103, AC007686, AB017602, AC005587, AC005695, M33132, AF111163, AC007253, Z15025, Z93016, AF118808, AC000377, Z84469, AL022336, AJ229041, AF002223, AC003080, AC003982, AC002403, AR036572, U91328, AC004787, AL031319, AL031311, L47334, AC004752, AL031230, AP000141, AF129756, AC005066, AL023494, AB029885, AC005180, AC005681, U95739, AL133404, Z54146, AC004859, U63630, AC005773, Z97630, AC004769, AC002395, AC002504, D87675, AC007238, AC002299, AC006042, AC006597, AC005412, A0007486, AC005919, AC004616, AL121591, Z93244, AL109829, AC005220, AL031670, L14752, AC007227, AB000931, AC004134, Z86090, AJ006345, AD000813, AP000281, AP000039, AC002996, AC006254, AC004590, AC004595, AC007371, Z68324, AL109627, AC002468, AF111170, U29185, AL096755, AC005872, AF184110, AL109801, Z75889, AL035468, AC003969, AC005004, AC004019, AC006262, AC007314, AL031432, AC006064, AC004242, U78027, AC004097, M26434, AC007684, AC004662, AC004985, AC005031, AC004771, AL022165, AC005081, AL109980, AC0G0115, Z97632, AC006023, AL009183, Y14768, AC002404, AL035422, AC004967, AC005922, AC011718, AC005065, AP000116, AC000111, AL031283, AC006208, AL034402, AC002347, AC005231, AC004910, AL049780, AL022320, AC005484, AC007055, AF045555, AC002480, AC005375, AC004025, AL049713, Z97183, AP001039, AP000505, AF165926, AC005765, AC009516, AC006972, L81583, AC005756, Z82189, AC004753, AC005566, AC004760, AC004039, AL009177, AP000493, AL022318, AC005736, AF190465, AC004699, AC005783, AF107258, AB023053, AC004620, AC004998, AC008275, AC004605, AC006948, AC002525, AC007052, L44140, AL133396, AP000108, AC005379, AC003104, AL021154, AC005209, AL096767, and AL034376. HUNAC68 1698 753817 1-190 15-204 AA299084, AW058660, R79123, and AI955484. HUNAB76 1699 968754 1-457 15-471 T78720, T85868, and AA299178. HUNAB42 1700 714264 1-278 15-292 AA299202, AW382627, and W69280. HUKFS69 1701 754186 1-276 15-290 N98250, and AL021068. HUKFL89 1702 574525 1-457 15-471 AI027884, N90218, W56483, and W38946. HUKFL71 1703 760581 1-227 15-241 AA348602, AW188860, T17332, AI634716, AA586433, AI049701, AI559282, AW238212, AA728938, AA806804, AI564301, AI002762, AI623364, AW068580, AI872000, AA531596, AW194077, AA758131, AW003612, AI365625, AI620266, AA720582, AA363003, AA628740, R61195, AA713705, AA626840, AA713714, T30418, AA827383, AI798242, AA179663, R49266, AW190484, AI075249, AI819262, N40092, AI188049, AA351808, AI475870, AA683091, AC006485, AL035422, AC005323, AJ003147, AL121754, AL035634, AL133371, AC007686, AC005150, AC002551, U07563, AL021578, AP000514, Z93241, AC005386, Z99943, AC006960, AC004383, Z97876, AC006120, AC002504, AL022326, AL035420, Z85996, AL031228, AC005231, AC005537, AF111168, AC002529, AL008634, AC004832, AP000502, AL021940, AB022537, AL109798, AL078460, Z98941, Z98742, AC005094, AC005484, AC006450, AL049569, AC005527, AC004921, AC000088, AC000082, AC000071, AF099810, AL022316, AF095901, AF001550, AC003007, AP000555, Z95114, AC006079, AC006441, AC005325, AL031846, AC006597, AC004796, AL121658, AC005529, AC007773, AF053356, AC005146, AC006449, AL035588, AC005632, AC005409, U73634, AC007325, AC007263, AC006455, AC004895, Z98044, AL022312, AC005058, AF111167, AL031984, AL049760, AC004887, AL035495, AF196969, Z98051, AL078638, AC007919, AL049709, AC005295, AC007151, AC000085, AC007917, AL035455, Z95113, AL079304, AC004084, AC004552, AC008009, AL049734, AL031733, Z84487, AC002400, AL133312, AC002381, U47924, AL049611, AC006023, AL135960, AJ131016, AC007666, AC005160, AL024498, AC004865, AC002492, AL031311, AF146367, AC002375, AL035413, L78810, Z75887, AC004900, AC004526, AL049777, AC004148, AC005678, AC000052, AC006480, Z97054, AC005531, AC004491, AC005535, AL034417, and AC005051. HUKFL52 1704 574523 1-482 15-496 AW303688, AC002302, and AL117325. HUKFK53 1705 577349 1-436 15-450 HUKFE56 1706 574381 1-213 15-227 W30961, and AA284307. HUKFD95 1707 796014 1-446 15-460 AA259075, AA251698, and Z56473. HUKEY01 1708 921504 1-333 15-347 AA913741, AI052134, AA838729, AA418342, AI368697, AA156454, AI275854, AI554346, AW193440, AA564981, AI274286, AA969728, AI920804, AI435811, AA410342, AI360949, W04701, N25790, AA115096, N23736, AA193407, N58849, AI858171, AA630452, AA649290, Z24907, AA757161, AA630461, AA780577, W15321, AI245223, AA363098, AI038657, AA860500, AA993680, AA435925, AI439836, AA651840, AA279471, AW338576, AA342107, AA676504, AA854457, N48087, AI539628, AI089644, AI095714, AI373864, AA639258, AI567507, AA432267, AA194632, AI280712, AA890333, AA890563, W72009, AI745574, N91475, N75263, C00067, AA302403, and AA431256. HUKER62 1709 772501 1-547 15-561 R51351, AA534218, AA580300, AI284322, H78278, AI610392, D52671, AA115034, AI299062, AA778315, W73534, AA393903, AI290762, AI521482, AA115506, AI439629, AI475831, AI688331, AA764845, AI285054, AA027198, AI344564, AA830343, AW103497, AA435644, AW152418, AI814349, AI953851, T87095, AA865531, AI937550, AI992099, AI492575, AI968561, AI990835, W46791, AI336624, W46919, AI380956, W73259, AI675500, AI685131, AA634802, AA482973, AI669123, AI973010, AI201952, AW262269, AI352386, AI470518, AI337432, AW274833, AI783962, AA987852, AI470225, AW083650, D61500, T33520, AI885985, T03350, AW150047, AA350468, Z38276, N26529, AI864257, N21584, R32096, AI372555, AI372554, H78277, AA045465, AW440715, AI620909, AA384495, AA046535, AW015422, AI336885, Z69667, and AC004754. HUKEP18 1710 957456 1-838 15-852 AA203189, AI057441, AW139922, AA719156, AI653844, AW104223, AI208345, AI535660, AI536138, T18597, D80045, AI535639, D59751, AI557262, C15076, D80164, AI557084, D59467, R29657, C14331, D80193, AI526078, AI525856, D81026, C14429, AI541365, D59787, AA585439, C14389, AI525556, AW366296, D80195, D80227, D59502, AI557533, AI525316, D50979, D81030, D59275, R45895, D80269, AI541205, D59927, D80022, D80188, D58283, C15406, D80166, D51799, D59859, D59619, AI525500, D80210, D80391, D80240, D51423, D80253, D80043, AI557864, D59610, AA305409, D80212, D80038, D80196, D80219, D57483, AI905856, D80366, D80378, D59889, D50995, AA585098, D52291, D80241, D80251, D80024, Z32887, AW177440, AI541356, AI557731, Z33559, D51022, AI557602, AA305578, AW375405, C14407, AW378532, R28735, R29445, D51060, D80522, R28967, D53161, D57491, T03269, AW178893, C14014, R28892, AA585378, AA585325, C75259, AA514188, AW179328, R28965, AI557155, AA585101, T11417, R29218, Z32822, D80248, D54897, D51250, AW369651, AI557751, AI541535, AA514186, AI541346, AI535686, D80134, AW352158, AI540903, D58253, AI557809, AI540974, AW375406, AW178762, AW178775, AW177501, AW177511, D80133, AA969188, D80258, AW176467, AW360811, D80268, C05695, D61185, AI557082, AA585356, D60765, F13647, D60844, C14077, AW352117, AI546829, AW377671, AI557408, AI910186, D80132, AW378540, D80302, AI526184, AW360844, AW360817, AW378534, AI541034, AW179332, AW377672, AW179023, AW178905, C06015, AI541517, C16294, T48593, AI546875, AI546999, AI557241, D80439, AW352171, Z21582, D59373, AW377676, AW178906, AW352170, AW179018, AI541321, AW179024, AW177731, AI557734, AI557317, D80247, AW178907, AW179019, D51213, D81111, AI557787, AW177505, AI546971, AW179020, AW360841, AW178909, D59627, AW177456, AW179329, D51103, AI557727, AW178980, AI557852, AW177733, AW378528, AW178908, AW178754, AI541374, AI526194, AW360834, AW352174, AI536070, AI546945, D80014, AW179004, AW179012, AF100707, A62298, A62300, A82595, A84916, AR018138, AR038855, Y17188, U87250, AR016808, AR062871, AJ132110, I19525, Y17187, AF058696, A25909, X67155, D26022, AR008278, AB028859, A67220, D89785, A78862, D34614, X82626, A94995, AR031365, D88547, I82448, Y12724, AB002449, AR025207, AF006072, U94592, AR016514, AR060385, A43190, A44171, AR031358, A30438, Z30183, X68127, AR008443, A82593, AB012117, AR050070, AR062872, AR038669, I50126, I50132, I50128, I50133, A85396, AR066482, AR066488, A85477, AR060138, A45456, A26615, AR052274, A86792, X93549, D50010, Y09669, A43192, AR025466, I14842, D13509, AR066490, AR066487, I18367, AB023656, D88507, AR054175, X76012, AR016691, AR016690, U46128, AR008277, AR008281, A63261, AR008408, A70867, AR017826, X82834, I79511, U79457, A64136, A68321, AR060133, AF135125, AF213384, AF123263, AB033111, AR032065, AR060382, X93535, and AR008382. HUKDY02 1711 920815 1-480 15-494 R54146, and W72450. HUKDU47 1712 719465 1-367 15-381 H56528, and W27624. HUKDG10 1713 968333 1-393 15-407 Z21273, and Z21324. HUKCP30 1714 690933 1-296 15-310 R93336, AI364837, and AI871934. HUKCO11 1715 967742 1-436 15-450 AW188043, AA743890, AA641852, AA654170, AA494552, and AA824490. HUKCL85 1716 529718 1-336 15-350 HUKCC25 1717 529723 1-246 15-260 HUKCC15 1718 518537 1-112 15-126 HUKAT59 1719 628540 1-385 15-399 AA299333, AA299334, AA488225, AI761274, W39643, AA436997, H26851, R69372, AA442825, AA133785, R48022, N78459, AL046919, AI659107, AA922133, W15236, F02924, AA135871, AW242187, R45109, AI355457, AI937442, AI270750, AI869489, T16709, H04785, F02239, R36219, AA938012, AI540377, T30366, AA491517, AA897754, AA972881, AA902408, H19244, Z39481, AI627407, AA133786, AI720129, R56889, AI911499, AI334362, H16569, AI285897, AI362708, AI148478, AI890959, AI961584, AI625445, AA099547, AI864641, AA947105, AW295635, AW304383, AW183032, AA580304, AI338026, AA725780, AA701287, AI815089, AA910649, AA059396, H10768, R47916, AI613048, AI827547, AA488171, AI362313, R60948, AI351348, AI268730, R69373, AA932084, H17326, H75830, D56341, Z43600, and AA099546. HUKAQ76 1720 502711 1-337 15-351 R02387, and AA299632. HUKAO47 1721 502911 1-367 15-381 R08548, AI360159, AI445049, AA299487, and AA831602. HUKAM19 1722 672076 1-315 15-329 AA299796, and AA299795. HUKAM15 1723 502912 1-636 15-650 AA166965, AI143571, AI187051, AI633250, AW135626, AI468530, AI916114, AA299797, and AA299798. HUKAL44 1724 716927 1-390 15-404 AA083174, AI344586, AA299808, and AI275232. HUKAJ91 1725 790487 1-146 15-160 N89673, AA877587, N89666, AW275503, AA548632, AI433318, AI800226, AI913521, AW235557, AI033607, AI741530, AA299661, AW003738, AI431440, D59328, AF108205, AF106698, and U67321. HUKAJ83 1726 524257 1-316 15-330 AA299762, AA299761, AA535406, AA063173, AA534010, M86120, AW069510, AA947547, AI281697, AA310158, F17891, AA584201, AI358431, AA552843, AI367975, AI754955, D51681, AA846952, N27763, AA367986, AA516226, AA866015, AA488746, D52044, AI653905, AA362349, R89904, AC004142, AL031846, AL031255, U78027, AL031577, AC005237, AC007308, AC004019, AC005578, AC000052, AC005971, AC007216, AC005703, AP000692, U95742, AL109984, AC005288, AF111168, AC005081, AP000115, AC004234, AL022313, AL020997, AP000553, AC006064, AC004876, AC004895, AL121653, AC005523, AC003695, AC009516, AF030453, AC005071, AL139054, AC006071, AC007536, AC005778, AC007276, AC004883, AC006441, AC002565, AC004477, AC005088, AC004814, AC005839, D87675, AC007227, AC003101, AC010175, AP000355, AC006254, AL031283, AC002350, AL022322, L78833, AC008101, AC016027, AL008582, AL049830, AC002996, AC005089, AC004921, AC006965, AP000047, AC006026, AL080242, AL035079, AL023575, AC006512, AC005888, AB016897, AC005387, AL079340, AC004884, AL096791, AP000359, AC007030, AL049757, AC005280, AC005755, AC005765, Z98036, AF045555, AP000113, AP000045, AJ003147, Z81364, AL022318, AC004526, AF134726, AC006312, Z95152, AC007421, AP000304, AF109907, AC006509, AP000350, AC006001, AF053356, AP000141, AC002316, AL035448, AL022323, AC006050, AB023050, AC016830, AC006449, AC007546, AC000085, AL033525, AL034549, Z86090, AC005940, AL132987, AC002470, AL049692, AC005846, AL021394, AC005323, AC004531, AC004825, AL023803, AL109798, AL021393, AC002492, AL049759, Z82244, AL031667, AP000555, AC005500, AC005527, AL035587, AL049709, AC004000, AC004778, AC006285, AC005212, AP000349, AC005412, AC004796, AL096712, AL096774, AL132777, Z95114, AC006130, AC007637, AC005488, AL096703, AC005330, AC002395, AL080243, AL078581, AL109628, AC005620, AC000025, AF205588, AC006014, Z97053, AC005231, AL031276, AL133485, AF165926, AC006538, AF141308, AP000959, AL021937, AC004859, AC004675, AL008718, AC006450, AC004263, AC005037, AL117258, U91326, AC006430, AC005246, AL022316, AP000501, AC006120, and AL021939. HUKAD77 1727 772734 1-409 15-423 H96061, AA300129, AI147406, AI189973, AA431411, and AI078297. HUKAB63 1728 625273 1-195 15-209 AI079608, AI807065, AI952291, AI590123, AI090727, AI016788, AA456134, N20016, AA977594, AI970077, AW029554, AA635175, AI680564, AI474417, AW339144, AI933942, AW152328, AA149927, AA303069, AI864866, H98815, AW170581, AA699755, AI391578, AW009047, AI982927, AA576948, AA485634, AA428599, AI016186, AA824314, AA991678, AA910276, AA576748, AA479608, AA829399, AA398673, AA933886, AA922521, AA868264, AA620744, AA303070, AA662449, AA568243, AA211758, AA913101, AI161248, AI797204, AA644052, C06116, AI693943, AA476960, AI799459, AA160700, AI673693, AI890207, AA642505, AA526838, W86624, AI241307, AI969413, W57802, AA602638, AA922005, AA954133, AA514739, AA838009, AI890528, AA909312, AA620353, AI423401, AA884139, AA192820, AI918960, AW236180, AA463209, AA621214, AA574061, N29954, F33718, AA913537, AA777231, AA864549, AA432235, AA703595, AI148263, AA868797, AA788644, AI084525, AI024640, AA299468, and AL137631. HUKAB25 1729 677470 1-461 15-475 AA303079, AA127017, AA702731, AA659016, AA316535, AA365415, AA304577, AA411655, AW170716, AI969252, AI264137, AI907629, AA603883, AW193546, AL120502, AW162022, AA016286, AA663086, AA661948, AA665330, AA663115, AI985942, AA640204, AI255015, AI255004, R10260, T89571, AA128969, AI053977, AI054418, AI343078, AW268322, W85860, AA976584, AA826177, AI708663, AI671052, AI719434, AA504355, AA443426, AI189872, AW419126, H21137, AA634238, AA218645, T62975, AI686563, F17700, AL045709, AA879430, AL031682, AC004963, AL008721, AL020995, AC005527, AC005529, AL049780, AP001052, AC004460, AC005274, AL031846, AC005245, AC007461, AC005730, AL109984, AF024533, AC005030, AL035071, AC004805, AC006596, AC005694, AL022316, Z82246, AL121825, AC002369, AJ229043, AL021920, AC005233, AC005874, AF134471, AC002456, AC004765, AB022430, AC005320, AC007055, AC006515, AC004645, AL022326, AC002565, AB020863, AC006065, AC004775, Z98946, AC006057, AC006142, AC005088, Z69648, AC005284, AC005837, AL079340, AC007666, and U89337. HUKAA54 1730 503630 1-441 15-455 AA303097, AL022325, and AL031588. HUKAA39 1731 503627 1-318 15-332 R58995, AW444583, AI139054, AA303128, AI422562, AW452316, AW136820, AI355998, AI871425, AI499766, and AC005789. HUDBZ01 1732 869026 1-519 15-533 AC000070. HUDBK39 1733 886368 1-474 15-488 N88782, N88601, AA247964, N84855, H58760, N83168, AA095359, N89520, N83991, AA096046, AA247827, N83992, N55698, N84048, AA095641, AA096066, N88518, N84718, N86694, N83993, N84712, AA471338, N84830, N87989, N84829, S78798, U48696, AF103726, AR066487, AF039698, AF045432, AF102850, AF032922, AJ243486, and U39066. HUDBE95 1734 795796 1-316 15-330 HUDBE64 1735 746508 1-348 15-362 HUDBE48 1736 869034 1-423 15-437 AI651392, AI912649, AI690582, AA101690, H02616, AI139898, AA731894, AW269260, AW248051, C04885, AW137058, AI597917, R41929, AI401381, AI125561, AA394302, AI884475, AI913287, AI915152, AI753690, AA295249, AW088536, AI380436, AI632150, and AU020861. HUDBE28 1737 686520 1-360 15-374 AI697533, AW204092, and AI963731. HUDBE02 1738 917361 1-123 15-137 AA585476, T18597, R28735, R29445, R45895, R28967, AA170832, R29218, AA585325, N86592, R28895, AA283326, R28965, R28892, R29179, AA585098, R29657, R29177, C16293, AA585101, D61254, C16315, Z28355, AI546875, AI557734, AI557864, AI525306, D53472, C16300, D57491, D60844, R29262, R29172, Z32822, D60765, AI526140, AI546971, AI541365, AI557763, D59751, AI546999, AI547250, AA585439, AI557262, C15406, D53447, D54897, C15120, D53161, D52835, AI541383, AI541374, AI541356, D59436, D61185, C16292, AI557740, AA585155, D55233, Z32887, AI526184, AI546945, AI525500, AI525431, AI546921, C16305, C15069, D57186, AI541517, AI547006, C16294, C15762, AI540967, AA092643, C16290, T19407, AI526194, AI541205, AI541535, Z30131, AI526078, AI525316, AI541013, C15737, AI557731, AI526073, D60730, AI541523, AI557787, AA585356, AI546996, AI547039, AI526191, AI541307, AI525556, AI557758, C16296, AI557727, AI546891, T41289, C14208, AI526016, AI541346, AA174170, AI541527, AI525320, AA514191, AI557807, AI525339, C14723, C14322, C14391, T41329, AI547202, AI557264, AI557155, AI547196, AI557084, AA585117, AI525286, AI557799, AI557408, AI547137, AI526113, AI557718, AI540920, AI541034, AI557809, AI526180, AI536138, AI526158, AI535639, AI526109, AI526024, AA585430, AI556967, AI557602, AI524890, AI541514, AI535660, AI540974, AA585453, AI557808, AI540903, AI546828, AI541390, AI541321, AI541506, AI541415, AI546829, Z33559, N87188, AI557279, AI526112, AI525332, AI541508, D54850, AI540882, AI546954, AI547189, AI526195, AI557796, AI541345, AI557039, N88113, AI657485, AI541422, AI546831, N88337, AI524904, D59458, AI557533, AI541515, AI541017, AI526117, AI546901, AI525656, N85682, AI557786, AI557802, N88532, AI557852, AI541027, AI557238, AI547071, AI540944, AI557285, AA585434, AI541410, AI525114, AI046024, D61060, AI547026, AI541492, AI048523, AI557041, AI557082, AI525168, AI557317, AI557810, AI525076, AJ243486, D50010, D13509, AR062872, AR062873, AR038855, AR062871, A25909, A20702, A20700, AF082186, Y09813, AJ244005, Y16359, AR054723, Z32836, AR038762, AJ244004, X81969, D78345, A43189, A43188, AR017907, AJ244003, X55486, AR018815, AC005913, A98420, A98423, A98432, A98436, A98417, A98427, AF045432, X82786, A98767, A93963, A93964, I63120, AJ244006, X76012, U39066, AR003381, U48697, and U48696. HUDAK54 1739 899753 1-822 15-836 AA247964, N88601, N89520, N88782, N84718, H58760, N84855, N83992, N83168, N83991, AA095359, AA247827, N84048, AA093224, AA096046, AA095641, AA096066, N83993, N86694, N84712, AA471338, N55698, N84830, N88518, N84829, AF154415, AF164678, AF165161, S78798, AF045432, AF103726, U48696, AF102850, AF039698, AR066487, AF032922, AJ243486, and U39066. HUDAK19 1740 671974 1-444 15-458 H16933, AA149496, and AA531296. HTTKG12 1741 969547 1-461 15-475 AA172361, AI537800, AI791659, AW272815, AI355103, F23338, F34506, AI934307, AI246996, AI242614, AW407220, AL045476, H51835, AI869797, AA503258, AW238341, AI805261, F23327, AI587583, AI587565, AI720141, AI471455, AA808725, AI865980, AW151761, AA342238, AI246192, AA524800, AI927275, AW265688, AI281474, AL046416, AI687343, AW270619, AW023111, AW372037, R34070, AI310464, AI521525, C14014, AI539024, AA743811, AW069227, AA657835, AI801563, AA484892, AA947369, AA992877, AI249688, T71936, AA468923, AW020150, AI537368, N71619, H79308, AI280266, AA364082, AA218684, AA533463, AI251436, AA084320, AW302017, AA351840, AA610433, AA936718, AI858165, AA350644, AA904275, AA714011, AA298365, AW272389, AI445216, H59856, AW275719, AA719433, AA720582, AW104163, T07451, AL118980, AI880889, AA583386, AA550959, AA292254, AA018923, AI935827, AW419389, AA846923, R73744, AA128592, AL134441, AA714110, R56485, AA809104, AI821945, AI587349, AW439703, AI536625, AA533054, AI223968, AI568659, AA992126, F32248, AW274078, T39390, AI205181, AA630122, AI367473, T48723, AI024339, AA774794, AA632765, AC006511, AC005740, AC002059, U47924, AC002985, AL031985, AC006538, AC005102, AF196779, AL031281, AP000065, AC004797, I34294, Z84469, AL022721, AL022322, AC004611, AJ006216, AC005914, AL009174, AC005189, AC004941, Z84487, AC004955, AC007450, Y15994, AF001552, AC002115, AL034549, AC004675, U95739, AL080243, AF088219, AC005378, Z93023, AC005520, AC005089, AC005015, AC005324, AC005212, AC004087, Z98257, AC004913, AL049709, AB023050, AC006512, AB001523, AC005632, AP000014, AC004491, Z97054, AP000514, AC006211, AC007225, AC004531, AC006958, AP000355, AL136295, AL008718, AC004024, AP000240, AL050318, AC004905, AL122020, AC004134, AC002546, Z85987, AL035400, AC005566, Z99128, AC002549, AL109984, AC006515, AL049569, Z97184, U85195, AC005529, AL035587, AC002347, AC005386, AL121655, AC000025, AC005591, AC004791, AL034418, AC006544, AB014540, AC005899, AC004659, AC005519, AL049643, Z82195, AE000658, AC007551, AC006371, AC007546, Z83844, Z98047, AC006285, AC006115, AC003043, AC005531, AC007032, AC005342, AC005264, AC006271, AC005670, AC005379, AL031291, AC005237, AF053356, AL035249, AC002536, Z84481, AC006197, AC009516, AC005730, AC008039, AC003962, AL034553, AL023575, AC009247, AL035683, Z96074, AC004216, AC020663, AC004655, L48038, AC003003, AC004158, AC005516, AC005280, AC004929, AC007541, Z93017, AL009179, AC005940, Z86090, Z93020, AC007731, AL021453, AC007055, AC003007, AF001548, AJ229043, AL049766, AL031602, AC004417, AL049699, AC004079, AL031005, AP000348, AC005082, AC007686, AL109798, AC004150, AC007842, AC000026, AC007387, AL117354, Z93024, AC005358, AC007371, AP001053, AC004896, AC005996, AC007226, AC005332, AL031594, AP000359, AL031431, AC004671, AC005274, AC005844, AC003101, AL117258, AL109628, Y18000, AC005017, AC007435, AC006530, AL049636, AC004912, AL035455, AL032821, AC007444, AL009181, AL031729, AC004139, AL121652, AL009051, AC007676, AC006124, AL031737, AC004167, AC005500, AF222686, AC006088, AC007283, AC005233, AR036572, U91328, AL049712, AL035460, AC006213, AC004890, AL035086, AL022302, AL035457, AC005746, U52112, AC005778, AL033527, AL031588, AF060568, AC007707, AC015853, AC009263, AC005043, U91323, AC006057, AC005913, AC005690, AC006270, AC005003, AC005071, U91321, AC007538, AF134726, AJ003147, AC007690, AL133238, AC004253, AL133445, AL121578, AC004834, M37551, and U02047. HTTKC85 1742 956206 1-436 15-450 AJ224604, AA279200, AA258999, and W37285. HTTJV79 1743 869602 1-434 15-448 AA825972. HTTTN26 1744 869612 1-891 15-905 AI356567, N90525, AA232991, AI148171, AI022165, AA233101, AA573721, AA448133, AI306380, AA447991, AA127550, AA127551, AW016855, AA243852, AI473237, AI005068, AA554071, AA570256, AA906902, AW014761, and AI359627. HTTJK06 1745 934094 1-564 15-578 AA853292, AL117470, and AB023143. HTTIX05 1746 931024 1-520 15-534 AI493098, AW024745, AA921917, W90789, and AI915946. HTTIR33 1747 974323 1-341 15-355 AC004491, AL050307, AP000023, AC004884, AL078472, AL008715, AC007227, AC005150, and Z98304. HTTIR04 1748 926772 1-557 15-571 AA083298, AA829975, and AB014535. HTTIN11 1749 965920 1-801 15-815 AL133824, H86873, and H86809. HTTJE08 1750 958169 1-427 15-441 AW052126, and AA101833. HTTIB12 1751 969568 1-336 15-350 R92571. HTTHJ56 1752 944914 1-258 15-272 D81882, AA193637, AA234876, T83136, H11688, AA258658, AA306506, and AA252212. HTTFG12 1753 751809 1-359 15-373 AA169457, AA172190, and AI636076. HTTEZ61 1754 742004 1-539 15-553 R13891, AI150008, and AI198021. HTTBQ59 1755 739445 1-550 15-564 AA237056, AA491051, H78425, and R92491. HTTBQ01 1756 917156 1-458 15-472 AI827837, AI142441, AI086379, AA813388, AA253028, H17296, AA613757, AI474835, and Z83845. HTTEO59 1757 900662 1-148 15-162 HTTEO53 1758 728344 1-763 15-777 W74401, Z45510, H79976, D81436, D53762, and D61200. HTTEJ56 1759 573669 1-492 15-506 R54109, AI884701, Z39259, R41821, and AW075808. HTTEB05 1760 932294 1-373 15-387 C74999, T90424, AB023197, and AL031672. HTTDO59 1761 744438 1-734 15-748 R82651, R82700, AA372368, N79122, AA033606, AI546974, AL133016, AL122061, AB021868, AF034080, and AF032872. HTTDM42 1762 460948 1-389 15-403 R95162, and H91087. HTTDL81 1763 694222 1-392 15-406 AA485538, H74053, N43924, N43932, AA280231, AA613434, and AL022328. HTTDL75 1764 766551 1-356 15-370 AA199666, AL120288, and H18766. HTTDA85 1765 784537 1-408 15-422 N46977. HTTCQ95 1766 796674 1-310 15-324 N57049, and AW078548, HTTCJ39 1767 709581 1-469 15-483 AA012877, AA021074, AC007450, AC009533, and AC008013. HTTCD06 1768 960599 1-483 15-497 R22892, R30952, AA767622, D80460, D60956, AI800613, D60394, AI750009, AI453046, C15178, R81201, and D59944. HTTCB87 1769 524841 1-224 15-238 H80337, AA769820, R16729, AI091785, and AW273500. HTTBR42 1770 714220 1-329 15-343 AA164855. HTTBP62 1771 932997 1-601 15-615 AA341024, and AA249649. HTTBO82 1772 780164 1-422 15-436 N59547. HTTBM03 1773 925409 1-193 15-207 R96101, and AL050318. HTTBI80 1774 781590 1-229 15-243 AA256038, and AA768241. HTTBH95 1775 530559 1-244 15-258 HTTBH75 1776 767520 1-422 15-436 R21404, AC006987, and AF146191. HTTBH36 1777 530567 1-299 15-313 HTTAQ60 1778 742377 1-615 15-629 H73605, R92625, AA300822, and T77356. HTTAP45 1779 717736 1-384 15-398 AA300727. HTTAP21 1780 671488 1-802 15-816 W94307, W79130, AA300911, AL023803, and AF086439. HTTAP09 1781 826343 1-427 15-441 AA189122, and AA300969. HTTAN34 1782 509454 1-455 15-469 AA252276, AA227154, AI656990, AA301077, AA301076, AL042627, AC004593, AL023574, and AC007536. HTTAJ93 1783 791413 1-406 15-420 R01464, AA300985, T87497, and Z75742. HTTAH03 1784 965134 1-282 15-296 AI198425, AI480040, AW054766, AI564875, AI359129, AI359233, AI422375, AI651642, AI056060, AA301255, T82079, T84917, T85537, T86503, AI954689, AI962153, T92050, AI742287, AA421072, AI244008, AA379174, AW135598, H84990, AA045378, H86604, AI580336, AA731146, R99375, H86921, AA007586, AA128609, AA062583, T85467, AA453722, H55168, AI200967, AA383353, T10083, and AA919169. HTTAC77 1785 772735 1-764 15-778 AI694695, AA913353, AW236100, AA846529, AW301152, N62629, AI366198, AA449338, AA694442, AI620459, W39523, AI521787, AA977228, AA600876, AA724335, AW078557, AA995242, AA860876, AW235851, W15410, AA456019, AA301436, AL122078, and AF198358. HTTAA94 1786 793001 1-555 15-569 AA191546, W91892, AA486427, AA694339, AA416561, AI140707, AA417297, H77647, H77648, W95110, AA303182, T19870, H26488, and AL031255. HTTAA39 1787 710355 1-284 15-298 AI800489, AW105035, AI480088, AW299975, AA303221, AI670831, and AA135748. HTLIP06 1788 934207 1-330 15-344 AI820928, AA405805, AI821678, AA813084, AA410617, AI821566, AA235536, AW302988, AI344933, AI344928, AW161579, AW268220, AI610756, AI537677, AA225339, AL036361, AI251221, AW103371, AI498579, AI683340, AI610645, AL041772, AW150578, AL038445, AI860537, AL036736, AI554245, AL119791, AL036403, AI815855, AA572758, AI627988, AI336592, AL039086, AI340603, AI866002, AL079963, AI950664, AI349004, AW074869, AI633419, AI312428, AI859464, AI521012, AI251205, AI308032, AI344785, AI783504, AI284517, AI434281, AW081255, AI922901, AI888944, AI308035, AW023590, AI345347, AW129106, AL119748, AL038605, AW117882, AA427700, AL036274, AL040241, AI349933, AI800453, AI800433, AW059837, AW238730, AI433976, AI636719, AW169653, AW268251, AL042628, AI923768, AL121365, AI491852, AI572418, AI252023, AL119863, AI923989, AL042551, AI318280, AA508692, AI828731, AI564719, AW190042, AI281772, AI889376, AI681985, AI524671, AI345608, AW268768, AW051258, AW117746, AI921248, AI611738, AI590120, AI829327, AI619502, AI677796, AI306613, AI632408, AI802542, AL043981, AI497733, AA658033, AI499285, AW088134, AI886753, AI174394, AI933589, AW026882, AI539153, AI269696, AL045266, AI620284, AI340582, AW002342, AI468872, AA640779, AI868831, AI539028, AW020693, AI334450, AA613907, AI335209, AI698401, AI445165, AI670009, AI862144, AI433157, AI702073, AL036802, AI873644, AW068845, AI648684, AI539771, AW403717, AI567351, AI340519, AI874166, AW071417, AI284509, AI633125, AL119049, AW103893, AI561299, AI476109, AI608676, AI446373, AI446003, AI922676, AI648663, AL036396, AW074993, AI349614, AI866608, AI888953, AI886124, AI250663, AL120853, AI224992, AI554218, AL042627, AI963216, AW301409, AW082594, AI571909, AI521560, AW149227, AI282326, AI343059, AW079159, AL036631, AI619716, AI284131, AL042544, AI312152, AI687065, AI612759, AW268072, AW089179, AI554425, AI926790, AI801325, AI500523, AI867042, AI696819, AA493647, AW075084, AI932794, AI280661, AI349937, AI699011, AW300889, AI349645, AI680498, AI537617, AI919345, AW088903, AI364788, AI500706, AI348897, AI307708, AI500662, AI251830, AI569583, AI866573, AI269862, AI366549, AL048871, AW118512, AI340627, AI916419, AL044207, AW073994, AI952217, AI569616, AI133559, AI611743, AI335449, AW151138, AI680162, AW083804, AW302973, AI696626, AI349967, AW268060, AW148716, AW005858, AI589993, AI250369, AL045997, AA494167, AW163464, AW022808, AW162071, AI608936, AI702406, AI689420, AI805603, AL049085, AL040456, AI289937, AI525669, AI436644, AW022682, AI869367, AW081797, AW080402, AL049314, I48978, I48979, AF113694, A08916, I89947, A08913, A08910, AL122121, AL122110, AJ242859, AL122098, U80742, AL050108, X65873, A08909, I89931, I49625, AL110197, AF113676, AL122093, 578214, AB019565, U72620, AF125948, AF146568, AL137550, U42766, Y16645, A65341, AL049283, Z82022, U00763, AR059958, X84990, AL133560, AF177401, AF106862, AR011880, AF118064, AL137557, AL122050, AL133557, AL110225, AF090896, AL117394, AI2297, AF125949, AF158248, AF104032, AF113019, AF113689, Y11587, AF118070, S68736, X63574, AL080060, U67958, AL133080, A77033, A77035, AL050277, AL117460, AL137463, AF090901, AL050393, AL133565, X98834, AL122123, AL049466, E03348, AJ000937, AF113699, AF017152, AF113690, AL050146, AL049452, AF090934, Y11254, AL049382, AF111851, AF113013, AF113691, E07108, AL117457, AL137527, AF078844, X82434, AL110196, I33392, X70685, AL137271, E02349, AL117583, AL137459, AF183393, AL110221, AL133075, AF090903, AL050149, AL133016, AL080124, AL117435, U35846, A58524, A58523, AF113677, AL133093, AL133640, AL050116, AL080137, AF079765, A03736, A93016, AL137648, AL117585, AL133606, AF090943, AL050024, AL049430, AL137538, AL080127, AL133113, X72889, AF097996, AF090900, AL050138, AF091084, I03321, AF017437, AF118094, AF087943, A08912, AL049464, AJ238278, L31396, AL096744, L31397, X96540, AL049300, AL049938, X93495, U91329, E07361, AL080159, I42402, AL137521, I09360, AL133072, AL137283, I26207, AF061943, I00734, E00617, E00717, E00778, AL133568, E15569, AF067728, M30514, AF119337, AL133077, AL050172, AJ012755, AR038969, AL133104, A93350, AL122049, AL137560, AF111112, AF003737, AR000496, U39656, AL133014, AF026124, A07647, S61953, AL137556, AL137526, E08263, E08264, U96683, I09499, AF026816, Y14314, AL137476, U58996, AL110280, Y09972, AF185576, AF057300, AF057299, AL137523, AF111849, Z72491, AF153205, E08631, U49908, AF162270, I17767, E02221, AL133098, AJ006417, A45787, AL117440, AF106827, AF079763, AR038854, AR013797, AL133067, L30117, Y07905, AL137429, X87582, X62580, AL133081, AL122111, X53587, AF132676, AF061836, AL080074, E05822, A90832, AF210052, AL137533, U68387, E04233, AL122118, AL110222, AL137480, AL137292, AC006371, AF051197, U62317, X92070, AF008439, AL137478, M86826, Z37987, E12747, AL080086, U78525, AL137294, AF067790, Y10655, L19437, A08911, U68233, I92592, and AL023657. HTLID06 1789 974047 1-648 15-662 AW238325, AA513916, AW169687, AI344844, AA371311, AI357551, D53046, AI880168, AW270284, AA554293, AA526514, AA371410, AI884861, D55004, D51877, AA317144, AI298977, D54301, D51997, D55588, AA384911, D51927, D56450, AI885465, R81453, AA365548, AW438916, AA364488, P13749, AI345654, AL135643, AI751162, AW162288, AI696793, AI565581, AA714140, R66997, AW128881, AI590404, AA586433, AW102955, AI914558, AA304790, H38817, AA295893, AA295899, AL040462, T06292, H41462, AA493829, AI214510, R48980, AW327597, AI359368, AI869786, AA572967, AW090629, AW327555, AL137946, AL137954, AW175641, AA583978, H21488, AI907629, AA373861, AW151727, AA658235, AA247731, N43757, AI630283, AI557323, AA435854, AA745560, AI761471, AA745431, AI053672, AA450199, AI801600, AA665293, AI345522, AA655002, R63239, AI921649, AI334443, AI859742, AW081359, AI376100, AI345459, AI336660, AA192740, AA178953, AI340453, AL043756, AW074059, AI064952, AI356904, AI922654, AI564284, Z96530, Z98884, AC004814, AC000114, AL135960, AJ131016, AC007450, AC004382, AC007878, AC005034, AC006398, AE000658, AL031643, AL008627, AC006210, AC005370, AL031430, AC005386, AL021808, AC006965, AC006952, AC005822, AC004671, AC008134, AC004593, Z99570, Z84487, AC007970, AL034370, AC004074, AC000027, AC006548, AC004659, D87014, AC004552, AC003101, AC006213, AF011889, AC004616, AL132777, AC012331, AC006030, AL078593, AL008708, AJ011930, AL133353, AL079305, AP000959, AL078476, AC004222, AC006544, and AL049829. HTLHV59 1790 965808 1-530 15-544 AA036821, AA877774, AA845452, AA902976, AW027037, AW245073, AI857490, AA948226, AA977183, AI819768, AW085596, AA363071, AA528041, AI804187, AW376089, AI763409, AI524117, AA622713, AW090272, AA973857, AI361156, AA515276, AI686841, AA971889, AI953946, AA595152, AI209096, AI474502, AA918802, AA581475, AI888756, AI129507, AA371872, AW304826, AA632326, AI274834, AI799750, AI206384, AI290279, AI590567, AI340981, AI683971, AI802753, AA352552, AI739258, AA524697, AA417825, AI147766, AA018444, R49435, AW167804, AI281446, AW008926, AI570321, AI143414, AA648251, AA768690, AI468510, T91019, and T34395. HTLHU81 1791 870150 1-863 15-877 AA488434, N76166, AA085536, AW390492, AA488573, AA375937, N39974, AA401426, AA307647, W05791, N64758, AI148945, C17327, C16676, C17892, AI200786, AI148951, T11417, D80258, C14227, D59503, D81111, D58246, AI535686, C06015, D80014, D80064, D80247, AA809122, C14389, D58101, D80195, AA514184, D80043, D59467, D80391, D59787, D80164, D59502, D58283, D51423, D80022, D81026, C14407, D80196, AI557774, C03092, D80168, D80227, C14014, AA305578, D57483, D59275, D80038, D80251, D80188, D50979, D80157, C15076, D80253, D80269, D80439, F13647, D80302, AI557751, D80166, D51103, D80193, D59619, D80210, D80240, D80045, D59859, C14331, AA305409, D80133, D51799, D50995, D80366, D81030, D60214, D80024, D59627, D59889, D80522, D80212, D80219, AW178893, D59610, D80268, AA400102, D51060, D51022, D80248, AA514188, H67866, D59927, H67854, AA514186, D51759, D80378, C14344, T03116, D59317, C14298, D45260, D80241, AW177440, D59653, D59551, D51221, AW360834, C14973, AI525242, AI525227, D59474, C14429, AI525917, AW360817, C14957, D60010, D59695, AI525923, D51213, AI525920, AW377671, AW375405, D45273, D52291, AW360811, C05695, C75259, T03048, Z21582, AW178907, D59373, AW178908, D51079, AI525235, AW352117, Z33452, C14046, C16955, AI525925, D80949, AI525237, AI525215, AW178906, AW360844, AA285331, AI535959, T03269, AW179328, T48593, AW375406, AW378534, AW179332, AW360841, AW377672, AW179023, AW178905, AW366296, AW177731, AW378528, AW178762, AW179019, AW378533, AW378532, AI525912, AW377676, AW352120, AW378539, AW178914, D80228, AW378542, AW367950, AW360855, AW176467, C05763, T02974, AW178909, AW179020, AW177505, AW352171, AW352170, AW178774, AW177733, AW179024, C13958, AW179018, T02868, AW178781, D51053, D51250, AW378543, AW378525, AW352163, C04682, AW177456, AW178911, AW378540, AW177734, AI525222, AW178775, AW179004, AW179329, AW178980, D31458, AW177728, AW178986, AI525228, AW178754, AW369651, Z30160, AW352158, C14077, N66429, H67858, AI910186, AI525928, AW177508, AR018138, AB002449, A82595, AR060385, AB028859, AJ132110, A84916, I14842, A62300, A62298, AR008278, AF058696, AR054175, I50126, I50132, I50128, I50133, AR008277, AR008281, AR016808, AR062872, X64588, AR016514, X67155, Y17187, A70867, AR060138, A45456, Y17188, A94995, D26022, A26615, AR052274, A43192, Y12724, A63261, A43190, AR038669, A25909, I79511, AF123263, A64136, A68321, AR066488, Y09669, AR066487, A67220, D89785, A78862, D34614, A30438, AR008443, X68127, I82448, AR016691, AR016690, U46128, AR032065, D50010, D88547, X72378, A63887, AR008408, Z82022, and AR060133. HTLHU63 1792 870147 1-515 15-529 R51662, H17203, R13772, R17328, and AF176701. HTLHS69 1793 870152 1-659 15-673 AW166505, AI085633, AI830616, AI948664, AI817701, AW183365, AW082276, AI471025, AA843215, W31421, AW439937, AA843291, AI476729, AA781027, and W04559. HTLHS05 1794 933720 1-712 15-726 AI348086, AI928156, AI074858, AW136076, AW243178, AI262696, AA627913, AI810972, AA595104, AI858055, AW043820, AI582191, AW001777, AI804955, AI798900, AI242330, AI887909, AW001248, AI813670, AW028151, AI336325, AW243042, AI299745, AI805058, AI923922, AI949719, AI741492, AI304384, M62028, AI276119, AI269740, AI684429, AI183994, AI401041, AI580934, AI097473, AA321296, AA480684, AI200633, AI719036, N42455, AA480650, W68465, AI348656, AA365138, AA335996, AW263563, T48387, AI648474, N66329, AA527274, AA863058, AA642939, AI277482, AI971175, AA884197, AI347141, AI863828, AA367149, AI474817, W68353, W25028, AI262960, AI054319, AI700621, H27099, AW205513, AA987972, AI015046, Z39325, W46985, R60687, T66319, F04561, AI656572, AI026748, F09789, F01927, F04682, AI521950, AI498629, H12192, AI214318, AI580497, H11935, AA136297, T15701, AI161214, AI890045, AI948515, AI866509, AI423812, T07980, and AB021226. HTLHK57 1795 894863 1-1127 15-1141 AA504779, AA491394, AA699349, AA004906, AA778225, AA005001, and AA806914. HTLHJ51 1796 865399 1-1017 15-1031 AA418490, AA418620, AI922829, AI264627, AW002386, AI080674, R61294, AI424861, AI610381, AI263843, AA004548, AW075751, AW080659, AI275462, AA570113, AW271292, W60463, AA453156, AA599740, H09296, H23133, AI473729, AA454079, AA054336, T35266, T35000, AI554231, AW078913, AA502766, AW151599, Z45311, Z38523, N84063, T66912, T31030, R44925, AA363400, R49157, AI521799, AI348847, AI344931, AL038456, AI628833, AW196097, AI345114, AI307494, AI345677, AI340627, AI349622, AI310606, AI345370, AI307446, AI828705, AI312271, AI824648, AI349814, AW081242, AI561087, AI862144, AI312261, AI345224, AI340644, AI311892, AI345026, AI952217, AI582871, AW082033, AW268261, AI553669, AW074869, AI491904, AI241678, AI307210, AI336513, AI336662, AI307569, AI345253, AI344935, AI348895, AI345736, AI313320, AI343091, AI310575, AI336495, AI310920, AI313352, AI307503, AI307736, AI335235, AW029349, AI336585, AI349266, AI334452, AI349787, AI340533, AI344938, AL036215, AI312146, AI590423, AI309431, AI312339, AI340537, AI345258, AI348854, AW148590, AI345471, AI307459, AI334895, AI636595, AI307507, AI348879, AI349245, AI311604, AI349805, AI343131, AI310930, AI349269, AI312333, AW168503, AI310945, AI312431, AI439089, AL038775, AW071380, AI573085, AW020381, AI335363, AI742068, AI311159, AI620093, AI348897, AI345397, AW054972, AI334930, AI307520, AI887775, AI340664, AI307542, AW132104, AA848053, AI349637, AI866465, AI334902, N75771, AW150804, AI336488, AI336565, AI311440, AI345737, AI345396, AI874109, AI922756, AI860694, AI349971, AW268253, AL047422, AI348969, N71180, AI567971, AI366959, AI358042, AI343140, AI366992, AW059828, AI349276, AI539690, AI345315, AA468418, AW274192, AI349645, AI345735, AI349246, AI242736, AI307708, AI865116, AI335476, F31233, F36033, AI345745, AI340659, AW071377, AI050666, AI345005, AI633061, AA427700, AI309443, AI343030, AI619754, AI690930, AW058233, AW021373, AL040694, AI271234, AI623736, AI349186, AI349279, AI310592, AI312325, AW071395, AI345739, AI345674, AI312143, AI340511, AI334920, AI446405, AI345014, AI345251, AI923357, AI310927, AI307578, AI436429, AI345608, AI349955, AI307456, AW075093, AI312432, AI635690, AI811840, AI581048, AF104032, AL035067, AI8777, S77771, X98834, E12580, A08910, A08907, A08909, M19658, AR068466, A08908, I09360, A08912, AR038969, AL133016, A08911, L13297, AF085809, AL137547, X63574, S76508, I89931, A08913, AR000496, U39656, AR053103, I89934, I89944, X69026, I49625, AL133606, AR034830, I96214, AL110225, A21101, AR038854, AP000130, AP000208, AL050024, AL050108, AL117394, AL137648, AL133098, AC002471, AC005374, AF177767, E12579, AJ242859, AF159615, AI2297, AF118090, AF143957, AF185614, AL080057, AJ006417, I77092, AC009501, E01573, E02319, E02152, E15582, Y13653, AL049465, AL136884, AF031903, AF141315, E05822, M30514, AL133557, AL137471, Y09972, U62966, AL133112, A08916, AB022159, AC006313, I48978, AL080086, AR054987, AF118064, AF013249, AL122111, I36502, AL049460, AL080127, U87620, AF090896, AL137527, AF182215, U51587, A17115, A18079, AC002382, E08516, U67813, AL050143, AL137526, AL133054, AL049300, AE118070, E03671, AF132676, AL137523, AF061836, AF125949, U68387, AL137656, AJ012582, AL096751, AL137555, AL133072, B01963, AF061573, X83508, U88966, A57389, U36585, AL133093, U92068, U02475, AL137640, X62580, U91329, I18355, U57715, AF106827, AB025103, E01812, I17767, AL080158, I34392, Y10080, S68736, AL110222, X62773, X96540, I89947, AL080118, A70386, AF022813, AL137461, M96857, AR060156, Z37987, AL050116, S69407, Y08616, AF180525, AB030279, AF019298, Z82206, AC006197, AC006112, AC007869, AF172930, AF100781, AF076464, A20553, AF090923, X99257, X70685, AL117583, AF017790, AL133075, X99717, AL096720, AF114168, D16301, I08319, AL049276, I29004, X66417, I41145, AL080060, AL137429, AL122049, AF175903, AL137557, Y11587, U67958, AL133080, A76335, AF210052, X89102, AL137554, X84990, I61429, AL117649, A91160, E07108, AL137712, AL117443, AL110224, AF139986, AL137659, A91162, AF081197, AF081195, AL110218, AF126372, L19437, AL133085, U00763, X57961, X72387, AF106945, S61953, D89079, AF114818, AF036941, X55446, AL117585, X92070, AF017152, AL137281, E08631, AF205861, AL122045, AL133077, AL050146, U49434, AL133014, A27171, AF146568, AL137705, AL050393, AF079765, AF098162, I68732, X59414, A90832, AL117629, U77594, AL137300, AL110159, M84133, AF111112, AB019565, A92311, AF012536, AL133104, AL137556, Y16258, and AF114170. HTLHB93 1797 945862 1-361 15-375 AI828062, AI028564, AW173227, AW102657, and AL035460, HTLHA63 1798 870172 1-554 15-568 AI218545. HTLGS10 1799 963458 1-470 15-484 AI560769, AI857497, AW151454, AW298056, AW007781, AW166326, and AW339468. HTLGR32 1800 928245 1-943 15-957 AI126041, AA812952, AA770544, N26185, AI222967, AA813689, AA815395, AW119183, and AA912724. HTLGP84 1801 782194 1-534 15-548 AA709009, AI570570, AA708887, AA062549, AI871015, AA757855, R41916, H80820, AA719341, AA701030, H30641, AA063144, AA757876, AA063046, R87769, H79988, AI003643, AW138067, R12796, and AA758374. HTLGK08 1802 958304 1-463 15-477 AA813640, AI766152, and AW403165. HTLGC43 1803 870228 1-484 15-498 AI653373, AI917476, AI650958, AI684722, AI632004, AI962304, AI341785, AW195932, AI653363, AI672453, AA778499, AA613494, AW197798, AI968944, AW001758, AA813413, and AA279933. HTLEQ92 1804 932882 1-296 15-310 AI962454, AI432386, AI087321, T08978, T77035, R12108, AI093960, R51395, AW196322, and AL117444. HTLEP21 1805 671151 1-402 15-416 AA737807, AW296355, AI694694, AI950417, AA448944, AI341643, AW083848, AA316241, AW076055, AI341859, AI950236, AW452665, AI796355, AI338467, AI367080, AF081280, AF079325, and U67172. HTLEN77 1806 772363 1-410 15-424 T89583. HTLEM92 1807 573400 1-419 15-433 AC005695, AR049867, and U75586. HTLEL16 1808 384492 1-425 15-439 R21318. HTLEG67 1809 751842 1-305 15-319 AI149770, AI809937, AA644408, AI808767, AI913293, R06443, and R06497. HTLDZ81 1810 778180 1-351 15-365 HTLDW27 1811 961353 1-587 15-601 AI479021, AW339781, AW276999, AI369304, AW392460, AI391729, AW392463, AW392466, AW392459, AW392461, AW392468, AW392462, AW372446, AI903603, AB028990, AF014461, and AF032667. HTLDO01 1812 913669 1-703 15-717 AI198827, AA397596, AA435832, AC002056, and AC000036. HTLDG43 1813 715439 1-123 15-137 HTLDB18 1814 868533 1-436 15-450 R18251, and C06467. HTLCZ79 1815 572853 1-273 15-287 HTLCX66 1816 578921 1-318 15-332 HTLCO02 1817 921045 1-429 15-443 AI360679, and AI217856. HTLCG65 1818 413333 1-129 15-143 AA420979, and AC006060. HTLCG59 1819 530039 1-205 15-219 AB007918, and AF202893. HTLCA03 1820 870290 1-236 15-250 HTLBH67 1821 751985 1-432 15-446 W19592, and AC005368. HTLBC07 1822 954111 1-662 15-676 AA626715, AA403001, and AW003923. HTLBB72 1823 766270 1-711 15-725 AW401867, H88137, W19173, AW390017, AI088172, AI970225, AW134697, AW390006, AI971802, AA991241, AA906307, AI808864, AA781530, AI918830, AA742991, AA936350, AI478204, AI523622, AA808091, and AA923464. HTLAI30 1824 690936 1-562 15-576 R40037, R60927, AW005925, Z41798, and F01644. HTLAF33 1825 870300 1-432 15-446 HTLAC61 1826 683247 1-153 15-167 T27009, Y18503, and Y18504. HTLAC39 1827 575343 1-214 15-228 AA323644, T94592, AA298192, N55287, AW162762, AA525407, AA167549, AI459879, N99245, AA522864, AA579082, F00937, W69639, AA132445, F04838, AL133906, AL133902, AA745302, AA297698, AI253376, AA457230, AL046416, N22837, AA568390, N35492, AI207476, AA657910, AI354233, AA523833, AA584756, T73021, AA155817, AA365056, AA363890, AL047480, H87756, AA831997, AA368329, R99076, AI636734, AA338216, AA847427, AW028179, AA357979, AI653783, AW057873, AA809179, AL138091, N34258, AW245354, AI073735, AA847508, AA553830, W52705, AA653291, AA629852, AA632765, F34605, R93224, AI471467, AA668711, AA302763, AA467740, AA654293, AI471455, AA468135, AI734119, AA352521, AI732720, H43183, AI475294, AI687343, AA368201, AW392414, AA133013, AI733856, AC005914, AP000501, AC002111, AC004862, AL132987, AC005547, Z74617, AP000359, Z92845, AL031985, AC005332, AC011456, AC006992, AC007225, AC005412, AL009174, AC005399, AC002375, AC002299, AC000070, AC006197, U52111, AL050337, AC009946, AL022721, AB023049, U24498, AC005300, AL031283, U95740, L39891, AL022163, AL035541, Z86090, AC004531, Z99716, AC004673, AL035534, AC006512, AL035089, U47924, AL078581, AP000141, AL035413, AP000088, AL035405, AC002470, D87675, AC002565, AP000344, AL034420, Z98044, AF111168, AC005821, AL031293, AC005235, AC005670, AC002425, AC006130, AC005796, AC009516, AC005058, AP000556, AP000557, AL049692, AL033504, AC005379, AL133382, AC002077, AL031295, AC004587, AP000495, AC002483, AC005702, AC006101, AC007388, AL133371, AC007151, AC005057, AC000035, AC007731, AL022313, Z98941, X64467, Z83838, AC004148, AL022238, AL049869, AL035072, AC005998, AL022326, AL121748, AC002302, AL035587, AP000065, AL049814, AC002472, AC003043, AC006023, AL136295, AD000092, D63861, AL030996, AL033381, AC006116, AC004098, AC005014, AP000343, AL022322, AP000114, AP000046, AC004242, Z97053, AC005899, AL049569, AC004893, AC006146, AL022316, AC003086, AL109801, AC004816, AL049553, AC004383, AC004813, U72790, AC000025, AC005089, AL050319, AL031662, AC006543, AL031587, AC007387, AC006544, AC000085, AC002326, AC005527, AC004079, AC005500, AL109963, AP000493, AC004882, AC007216, AC004858, AC003687, AL122023, AC004491, AF109907, AC004883, AL137549, AF020662, AC004790, AC005265, AL049653, Z98750, AL023575, AC007868, AC006141, AC004466, Z81365, AC008115, AC006210, AC005669, AL049570, AP000513, AP000353, AC009263, AP000550, AC002314, AL133163, AC006080, AC004985, AC004841, AC006486, AR036572, U91328, AL021878, AC002511, AC005272, AL034344, AC005826, AC006379, AC005800, AC008018, AL031007, AP000352, AC004849, AC006449, AL080243, Z93244, U80017, AC006538, AC006011, AC004106, AC005529, AC005160, AC007565, AC003972, AC004792, AC007546, AC005182, AC007746, AL031984, AC005005, AC009247, AF196779, AC008078, AC006312, AC009731, U82828, Z83836, AC005324, AL031729, Z99129, AC003108, Z93017, AF047825, U07000, AC005066, and AC005839. HTLAB55 1828 732480 1-451 15-465 T65363, and F11993. HTLAB29 1829 879168 1-432 15-446 AA023022, H51019, AI309636, AI569285, AI431902, R90861, AI740858, and R23430. HTFBE02 1830 920507 1-571 15-585 R92414, AA197116, P00607, AI923217, AI814569, AI804663, AI762903, AI804682, AI143304, AI082030, AI139520, AI911904, AW274978, AW450838, AI216343, AI183410, AA680119, W93273, R92413, W93272, AI918971, T51116, AI823928, C15320, R42713, T51024, T96094, AI422647, AI216344, T96093, AI936703, AI869077, F00114, AI741425, C00216, Z66165, and Z56024. HTEQS95 1831 972746 1-654 15-668 HTEQS90 1832 973426 1-667 15-681 HTEQP03 1833 870516 1-584 15-598 AI652668, AW196588, AI611041, and AI696211. HTEQN83 1834 908528 1-331 15-345 AA442506, AA436703, AA080897, AA219287, AA214213, AA332559, AA356572, AW197626, W86428, AA083980, AW239273, AL042822, AW137277, AW197400, AW197285, AA772083, AW206752, AA854258, AI934409, AL096747, AB021642, AB021644, and AB033024. HTEQB08 1835 958291 1-711 15-725 AI144505, T83402, AW439340, and T81586. HTEPY28 1836 870559 1-682 15-696 AA412612, AA412499, AA719038, and AI149873. HTEPV63 1837 870549 1-917 15-931 AI217359, AA229749, AI990822, T80962, AI393339, AA935552, AC005844, and AC006205. HTEPE35 1838 948475 1-825 15-839 AI935040, AA861064, AA933697, AA707583, AA872105, AA398866, AA609626, AA620685, AA435866, AA812556, AA781805, AA993718, AF012362, AI217888, and AA824315. HTE0Y82 1839 948845 1-489 15-503 AA724785, AW341727, AI990635, AW138616, and AJ010949. HTE0083 1840 836721 1-720 15-734 AA885943, AI807908, AI214900, AI810745, AA725810, F31353, and H91431. HTE0E28 1841 870581 1-846 15-860 AI222323, AW274395, AW104230, and AA917623. HTENY44 1842 870588 1-320 15-334 AA860344, AW449340, AI188119, AW241563, AI218844, AA725683, AA860397, H48932, AA398488, AA416572, AI654971, AA719259, AI797656, AI337070, AA416676, H52862, AA402604, and AL137366. HTENV06 1843 933294 1-479 15-493 N41901. HTEN574 1844 773925 1-544 15-558 N41653, AI879320, AI879319, AW249274, AI928959, N33827, AA701980, AA156930, AA777363, AL047958, AL048281, H95107, W68434, AI015217, AA364327, W68552, AA909383, W32502, AI188322, AA906240, AI741757, AA021053, AA329553, R16958, AW401707, AA281392, H00750, AA032085, W25157, N88679, AA534002, AI142442, AA552483, T85967, T75519, W88713, H94009, AI985732, AW248852, AI362972, AI240796, AI929211, AI129518, W84587, W84606, AI708380, AA156806, AA954310, AI369295, AA745783, AW291743, AI096816, W88714, AA301938, AI167203, AA356672, P23466, AA666297, W60290, AA922513, W37200, W02166, W60381, AA090596, AI040943, AA535548, AA628365, AI937756, AA576306, AW206638, AA927434, AI565666, AW292178, AI266717, AA181912, AI078402, AA429252, N24950, AA430649, AI189422, AI348358, AI690429, R55029, AL047959, AI811153, AA430402, AI741768, AA774634, AI567256, AI400297, AI004611, AA488479, N93305, AW406490, AA582428, AI554548, AL048282, AW193651, T79324, H54744, AA321085, AI866522, AA037421, W79170, AI239605, AA352112, AI439069, W74366, AA096370, F37003, F33844, AA649533, AI300497, AA995088, F13662, AA632491, AA886406, N83253, AW272778, AA721011, AA744603, and AC004148. HTENR26 1845 870595 1-292 15-306 AW374010, AI360575, AI018337, AW188121, and AC005879. HTENQ92 1846 790908 1-639 15-653 AW188190, AI026684, AA861425, AI656213, AI656331, AI148424, AI597882, AA978263, AI806072, AI560944, AA609392, AW103266, W19795, AW341673, AA135775, AA131502, AI274049, AI559891, AA131402, AI797927, and AA135731. HTENP08 1847 958382 1-433 15-447 AW293376, AW002918, AI206147, AW235254, and AI968897. HTENL95 1848 795314 1-652 15-666 R95033, H98000, H15506, H54108, Z43087, and F07410. HTENL73 1849 974363 1-705 15-719 AW368483, AC004671, AB015617, and AB029004. HTENA08 1850 958380 1-193 15-207 AW118931, and AI205921. HTEMY05 1851 880592 1-349 15-363 AA074939, X85715, and AA193675. HTEMV66 1852 813038 1-456 15-470 AA430250. HTEMU66 1853 944419 1-1078 15-1092 AL039924, AL045794, AW013814, AL036630, T02921, AL044412, T24119, AL044364, T24112, AW450335, AL039476, D51250, D80253, D80043, AL040992, AL039109, AL038531, AL037726, AL039629, AL039625, AL039648, AL038837, AL039074, AL039678, AL039108, AL039538, AL039564, AL039156, AL039659, AL039566, AL039509, AL039521, H00069, AL039128, AL044407, AL036973, AL045337, AL037051, AL045353, AL039386, AL039423, AL045341, AL042909, AL039410, D59787, AL039150, AL044530, AL038821, AL038025, D80219, AL036725, AL043422, D59275, AL043445, AL039459, AI535983, D80227, AL043586, AL043423, D80240, AL043441, D80210, D51423, T23947, AL036650, D80134, AL036196, D59619, D80391, AL037639, D80193, AW451070, AL037615, D80196, AL036767, C14227, AL039085, AI535783, D80949, AL036117, D80366, D59927, AL037526, AL042334, AW452756, D80168, R47228, AL036238, AL036679, AL037601, T11051, D81026, AL039504, C14014, D50995, C75259, AL039842, AL036964, D80045, AL036733, AL036158, AL037027, AL036924, AL037054, D59889, AL036765, T23659, AI557751, AL038851, T23658, AL037177, AL036998, D80022, AL037047, AL044413, AW293068, AL037643, AL036227, AL036418, AL036133, D80038, T11417, AL037082, AL036163, D58283, D80195, AL036207, AL037124, D81030, D80188, AL037021, AL036191, AL036167, AL036132, AL037049, AL037679, AL036190, AL037600, D51799, AL036139, D80378, F13647, D80522, T03269, AL036152, T23656, C14429, T48598, D50979, D80212, AL036900, Z21582, AL037178, AA514190, AL048425, AA285331, AW451416, D59502, AL043613, D58253, AL039555, AL043585, D80166, D59859, AL037085, D80268, D80269, Z25782, AL037569, D80024, D52291, C14331, AL036174, AL036808, AL036953, D57483, Z99396, D59610, AW450376, AL044178, D80241, AL036150, D81111, AI910186, D80164, D59627, C14389, H00072, C15076, D59467, D51060, AA305409, AL036268, AW178893, D51213, D51079, C14298, AL038043, N47620, D80251, AW177440, D51022, C14407, AL044447, AW179328, D80014, AW178775, AL037077, AW378532, AA305578, D80064, AW352158, D80248, D59695, AI905856, AW369651, D51097, AL043840, AL037002, AW178762, AA514188, AW177501, AW177511, AA514186, D80133, AW360834, AL039417, AW360811, C05695, Z25783, AI557774, AW135155, D80258, T02974, AW352117, AW176467, AW375405, AW378540, AW377671, AA809122, AW366296, A25909, A85396, A86792, A44171, A85477, X68127, AR062871, A84772, A84776, A84773, A84775, A84774, AR037157, AR017907, AR062872, AR062873, AR067731, AR067732, A58522, A91750, A20702, A43189, A43188, A20700, AR036905, A95051, AR038762, A95117, A38214, A98767, AR031374, I56772, I95540, AR018924, A49700, A63067, A51047, A63064, AR018923, A48774, A63072, A95052, A48775, AR068507, A18053, AR068506, A93963, A93964, A23334, A75888, I70384, AR043602, AR015960, AR043603, AR043601, A58521, AR000007, AR015961, A15050, A60111, A23633, AI0361, A23998, AR007512, AR020969, I60241, I60242, I63120, AR054109, 103343, AR031375, AR022240, A58524, A58523, A81878, A24783, A24782, E12615, AR035193, A92133, E14304, A27396, AR027100, I28266, A49045, E16678, A82653, E16636, I06859, A93016, I25027, AR000006, I26929, E13740, I44515, I26928, I26930, I26927, A58525, I49890, I44516, A58526, A91753, AJ244003, AR025207, I18371, E06034, AF156296, AI3038, A29289, AR029417, AF156294, AR067733, AR029418, AR067734, A64081, AR028669, AR028668, AR028667, AR028670, AR017908, A68112, A68104, A98467, I62368, AR031488, I13521, I52048, I44531, A84746, AI7115, AR028672, AI8079, AR038066, I50882, I15353, I66495, I66494, I66498, I66497, I66496, I66486, I66487, A71440, A71435, A67220, I13349, A07699, E08322, I74623, A60109, AJ244004, U87250, I00081, A70040, AR028564, A83643, A98420, A98423, A98432, A98436, A98417, A98427, A83151, I01968, AI3388, E00974, A02228, E00954, E00952, E00953, E00955, I08049, I43960, AR021440, E03165, E02221, E13364, AI0360, E02679, E02104, E02098, A92666, E02001, B01718, E02003, E02102, E03550, A28163, E02100, E01997, A58998, E02291, E02292, E02293, E01999, E02396, E02327, E01563, E02431, E01693, E01696, A92668, AR005163, AR005154, AR005157, AR005160, I09250, AR005153, A92667, E01024, AR050583, AR050584, E02430, E01148, E12527, E01503, AR005165, E12523, E02432, A49701, A62009, E01216, I77211, A95096, I70974, I31847, I31848, AR060673, AR060676, A95106, A95105, A80476, A91965, E01324, I08638, A80474, A94048, A94061, A80477, AR035224, A80475, A94046, A94054, I63560, AR031529, A49428, I63561, I63563, and E16036. HTEMS01 1854 915308 1-576 15-590 AW182380, AI016150, AA436052, AI016144, AA459652, AI110776, AC007227, AC004536, and AL049761. HTEMO58 1855 964769 1-475 15-489 AI026760, H54090, W90174, AI016127, and U22296. HTEMN80 1856 775543 1-301 15-315 T80539, and AI719083. HTEMM91 1857 938396 1-378 15-392 AI655972, AI809237, AI872211, AJ377032, AJ381901, AA523409, AI150552, AI248517, AW328508, AA523391, AI241274, AA609120, W92335, AW194863, AA580479, AI912966, AW243314, Z25384, AI217725, AA531424, AI142666, AW137703, W56565, W56787, AI678791, F17380, R95131, AW057531, and AI825787. HIEMI51 1858 870613 1-583 15-597 AI149866, and AA918162. HTEMB57 1859 849214 1-456 15-470 AA398093. HTELY90 1860 787549 1-356 15-370 AI022425, and T86122. HTELV29 1861 806421 1-627 15-641 AA083981, AL043302, AL050276, AF194030, and AF185576. HTELP07 1862 952274 1-550 15-564 AI005651, AA502325, and AI005304. HTELM71 1863 954982 1-509 15-523 AA843728, AW303661, and AA813137. HTELA02 1864 918699 1-602 15-616 AI651239, AW268856, AI024356, AJ016924, AI016923, AI698585, AA609414, AA620951, AW072208, AI696034, and AI340253. HTEKU62 1865 754010 1-713 15-727 R13043, AA402245, W03238, and AA293855. HTEKI62 1866 812862 1-472 15-486 AA741257, W23913, AA769417, AI923864, AA099994, AA113016, AI633572, AI129921, AI740509, AI087861, AI198728, AA451698, AA811514, AW328432, AI345992, AW135872, AI865582, AA769447, AA716235, AA946657, AI818126, AA742292, AW025858, AI092084, AI864067, AI992065, AW027054, AJ129952, AW105702, AA527064, AW166911, AI969997, AW263370, T12481, AI571406, AW243885, AA192190, AW134596, AI143876, AI143870, AW136628, AW009874, AI475650, AA063520, F21628, AA781441, F37014, AW074003, AI928446, AA736768, N91862, AA774271, AI611242, AW363815, F33207, AW328431, AI470616, H39778, W76151, W72588, AW444846, AW368798, AI479056, AI861919, AI223368, AI760686, AA973718, AA991724, AA804626, AW449436, AI217528, AI246328, AI391628, AA977169, AI222649, AI453599, AI825699, AI968087, AA910938, AW294100, N74597, AI587076, AI738417, AI818572, AI347378, and C00207. HTEKH17 1867 942526 1-643 15-657 HTEKD77 1868 772397 1-414 15-428 N47372, AA029276, AW173125, T51928, AW197647, AA436376, N56847, AI142573, AA885319, W26719, AI961121, R52187, AI032543, AW009278, T51718, AA992217, W37315, AI370687, AA495856, AJ073556, AL041264, AF147339, and AP000533. HTEJV94 1869 793039 1-381 15-395 AI628611, AA416585, AA420969, AW271467, AJ831883, AI928360, AA421125, AW001638, AA397955, AI656005, AW016672, AW003460, AL110224, and AC003669. HTEJO46 1870 717850 1-388 15-402 R72953. HTEJN12 1871 653252 1-443 15-457 AA223373, AL096763, and Y18004. HTEJL30 1872 696784 1-386 15-400 R92318, R97141, D61526, W58524, R13204, AA333107, AW163212, R55599, H23092, D52777, AI929587, C05240, R19781, D61319, AA150352, Z46053, AA355121, AA296708, AA323111, D53669, R26633, H08329, AA317832, AA322876, W01316, AA973604, AA374431, R49663, AA296782, H23093, H85812, AA149563, AA318184, AI368381, AW088920, AI253781, R40292, AI928933, AI857794, AI452755, AI160425, AA975568, AA961868, AI718865, AA776210, AA025635, AA337795, AI191849, W73632, N79435, AA679726, AA865487, W78161, AW339133, AI582690, W58412, AI744177, AA902205, H97698, AI338657, AI338667, AW452422, AI187166, AA330474, AA333363, AA976009, AA126618, AJ239435, AI572582, AA085720, R55362, AA360533, AW166355, AI879369, AW163740, AI752339, AI302066, AI954021, AA355733, T57729, T60002, AA332269, AW160676, AW403792, AA111927, D61306, N31004, AA064830, W79204, D53612, AA961222, AA845309, AA186387, W07796, W73680, N58648, AA642523, AA151815, AI805801, T30103, D54012, T36033, AA393418, AF092135, and AL109701. HTEJC70 1873 490772 1-587 15-601 R94482, and AJ004651. HTEJB07 1874 953801 1-451 15-465 AA993947, AW134645, AA884829, AI004532, AI150514, and AI239661. HTEIS34 1875 887112 1-371 15-385 AI002739. HTEJS25 1876 870660 1-390 15-404 AI208897, AI187424, AA682756, and AI187850. HTEJN26 1877 684711 1-403 15-417 R72964, W76526, R64535, and U82396. HTEJL36 1878 708304 1-425 15-439 AA417003, AA835058, AI424995, AI220270, AA694436, AW182313, R20520, AI382131, AI004786, AA418740, AA418795, AI190974, Z39070, AA742556, and AI809322. HTEIJ58 1879 491030 1-528 15-542 N71729, N71226, AP000041, AP000109, and AP000285. HTEID15 1880 395868 1-247 15-261 HTEIB38 1881 839966 1-318 15-332 AA724539, and AA960890. HTEIB37 1882 870671 1-336 15-350 HTEIB03 1883 921926 1-223 15-237 HTEJA57 1884 734983 1-489 15-503 N38963, and R92356. HTEHX57 1885 734976 1-442 15-456 AW451115, AI863336, AW104507, AI692981, AI652017, AI827145, AI017283, AI955549, N33485, R76560, AW409808, AI207003, AI202422, and AI927281. HTBHV11 1886 967439 1-561 15-575 AA916546, AI204535, and AL021331. HTEHS17 1887 664436 1-391 15-405 AA424196, AA846387, AI797455, AA778547, AW340809, AI217364, AI188208, AI150580, AI123441, AI027637, AA770175, AI150190, AF012356, AA909271, AF012355, and AA442327. HTEHJ11 1888 964956 1-242 15-256 C04728, AA381098, N45678, AA480568, W69682, AA397755, AA476511, AA476550, AI860245, AW024421, AW382036, AW382039, AA838817, AW382042, AW382037, AW381999, AW382041, AW381961, AW382000, AW381997, AA934010, AI363359, W69923, AW190584, N36268, W44317, AA181315, AI864889, AA130883, AI745226, AI934734, AA187057, W38774, AW382054, N26942, AI469219, AI380284, AI380273, W45689, AI057575, AA725447, AI360479, N48961, and AI057565. HTEGW02 1889 920628 1-1006 15-1020 AI288698, AI914273, AI203577, AI696478, AA913934, AA812691, AI573252, AI936975, AI015501, AI280024, AW054753, AA975903, AI371833, AI160502, AA844728, AA687959, AA393300, F34643, AA813782, T53463, AI091343, AA435624, AA595143, T53462, AI364294, and AI217827. HTBGU55 1890 931017 1-376 15-390 R61288, R05576, AA778664, AA280073, AB014581, and Z98752. HTEGS24 1891 932987 1-598 15-612 AA256743, AI374955, AI123527, AA251700, AA455406, AA429834, AA618437, Z28611, AI433315, AA331686, AI498096, AW203957, AI377211, AA770064, AA808245, AA828466, AA098810, AA331825, AA814045, AA101241, AI078061, AA625885, H53435, AA357747, and D42054. HTEGJ74 1892 765901 1-474 15-488 R13795, and R14717. HTEGJ56 1893 732630 1-607 15-621 N32789, AA992305, AI829630, AI453589, AI037906, AA490671, N47354, AF106857, and AF026169. HTEGJ38 1894 709420 1-356 15-370 W87922, and AA694342. HTEGH60 1895 545137 1-207 15-221 AI125270, AI025275, AI017509, AA724721, AA970833, AA904629, and AC002128. HTEGC30 1896 690998 1-463 15-477 N51343, AI341075, AI967945, AL035252, Z79996, AL031775, AL021978, AC002384, and AC002455. HTEFX90 1897 887616 1-568 15-582 N41791, AI734225, W21309, AF026169, and AF106857. HTEFU18 1898 666920 1-623 15-637 AA011636, AW136535, AA641738, AI242200, AA972854, AI357112, AI252660, AI919234, AI732405, and AW379801. HTEFO46 1899 719280 1-537 15-551 AA188885, AA189066, AA834951, AA971947, AW389450, AA856992, and AA189065. HTEFO28 1900 685383 1-470 15-484 N78395, and H45135. HTBEU78 1901 530196 1-327 15-341 AL044999. HTEEU35 1902 707717 1-102 15-116 AC004259, and AC004600. HTEEU27 1903 575476 1-275 15-289 HTEEU18 1904 530203 1-348 15-362 AA442512, AA002017, N68854, AF122013, AF064102, AF000367, and AF064103. HTEEU17 1905 530200 1-371 15-385 HTEET22 1906 675071 1-395 15-409 N55308, AI201311, and AA709195. HTEEF25 1907 677513 1-329 15-343 AA461517, AL040379, AI825108, AL040378, AC007981, AC011718, AC008103, AC012330, AC007708, AC007324, AC009288, AC008079, AP000550, AC007325, AP000552, AC008018, and AC008132. HTEEB82 1908 780161 1-326 15-340 H53320, R97852, AI032585, H53321, R97802, AL033531, and AL034424. HTEDX39 1909 530201 1-246 15-260 AC005726. HTEDX04 1910 927850 1-330 15-344 AF111169. HTEDX03 1911 925353 1-190 15-204 AW002847, AC005300, and AC006946. HTEDW96 1912 881958 1-539 15-553 AA101046, AA860334, AI240068, AI381744, AA064659, M79124, AB006626, AF132607, and A86973. HTEDW59 1913 530448 1-201 15-215 AI139615, and AL117627. HTEDV86 1914 785818 1-497 15-511 W87362. HTEDU53 1915 727362 1-443 15-457 N75217, AI827641, and AI313263. HTEDS40 1916 934047 1-496 15-510 N64316, and AA418089. HTEDS06 1917 960645 1-839 15-853 AA557354, AA004230, AA702179, AI671185, AI924143, AI609113, AI056239, AI638795, AI337375, AA634413, AW250803, AA417152, AL135398, AA478510, AA195614, AA190630, AI814763, AA827285, AI091408, AI638180, AI080126, AA632206, AI379107, AI288872, AI263619, AA626405, AI679151, AI754325, AI769841, AI559213, AI679722, AA417030, AA552345, W93249, AA007263, AI969543, AA766364, AA534494, AI038181, AA960978, AA449336, AA573241, AW043937, AA725439, AI291838, N73539, AA189108, AI699813, N73585, AW104716, AW166044, D19671, AW192890, AA454518, AA621586, H73339, N54283, AA910989, H14801, H05505, N56013, H75580, AI038699, AA248270, AA149737, H70079, AA808510, AI806228, AI806407, AI628327, AL079833, W93248, AA478509, and AF044588. HTEDO75 1918 767024 1-184 15-198 HTEDK72 1919 766343 1-339 15-353 AI693509, and H95965. HTEDJ92 1920 522827 1-294 15-308 HTEDJ63 1921 508086 1-310 15-324 Z98257. HTEDI09 1922 522969 1-397 15-411 AI797509. HTEDI01 1923 961028 1-230 15-244 AC006960, AC005015, AL035249, and AL049569. HTEDH90 1924 909165 1-403 15-417 R79137, AA314329, AA323430, U69560, AC007731, and AC005500. HTEDH76 1925 522940 1-208 15-222 AC004945. HTEDH42 1926 615250 1-459 15-473 C03196, C03292, F00515, AA361228, AW003009, AA626353, AW403239, W67213, AA314421, W05346, W63719, AI346486, W24987, D12319, D11537, AA423922, N45183, AR053393, and AF092130. HTEDH30 1927 522936 1-237 15-251 AL049697. HTEDH17 1928 522938 1-371 15-385 HTEDH06 1929 869427 1-392 15-406 AC006251. HTEDG75 1930 890715 1-358 15-372 HTEDG26 1931 519947 1-384 15-398 AW246994, AA421090, AA421091, AA397662, AA375279, R83399, AI638717, AA306667, AA747622, and AC000378. HTEDF96 1932 614726 1-323 15-337 AA242852, AA252186, AI129391, AA743400, AI934605, AA531278, AA705950, AA418351, AA834128, and AC006942. HTEDF70 1933 522977 1-294 15-308 AC004983. HTEDF60 1934 742368 1-356 15-370 AI656191,Z21349, andZ21348. HTEDF22 1935 908406 1-291 15-305 AC002418,Z83843, andAC004386. HTECE66 1936 522997 1-403 15-417 HTECE62 1937 523002 1-407 15-421 AW241925, and AC005232. HTECE61 1938 789732 1-543 15-557 N80927, AA400153, AI027600, W58447, AA813400, AA746206, AI139801, AA828177, AW375643, AI279610, AI359755, AA444123, AA443944, AA569017, AA451805, AI089230, AI632987, AI338403, AI262825, AA767495, AI005034, AA453635, AA454013, AI560993, AW250814, T30813, AW149100, AW327945, AW207031, AA629893, AI342923, AA922333, F37015, AI745194, AA676942, AI086189, AI276499, AW058509, AI682025, AW004973, AW009042, AI367703, AI445623, AI241535, AA441932, N73089, AW295548, AI188497, F04870, F10561, W58482, Z41848, T35208, AA548624, AI094343, AA923598, AW440500, W76342, AW080667, AI720047, T17396, R37034, F22096, R39180, AA833987, AA197182, AA426126, AW363378, AI797280, AA196359, T19458, AI743371, AA090309, R34367, AA446271, T61317, AW407104, N71508, AA075086, AA383602, C21530, AI371957, AA192312, N22129, N91820, AA374751, AA213591, AA813578, H43284, H97310, C00318, T10425, T98391, AA832076, AI049609, AA740854, AA349688, AA369853, and AL035405. HTECE51 1939 870723 1-301 15-315 HTECE39 1940 650885 1-389 15-403 HTECE31 1941 508104 1-284 15-298 HTECE08 1942 960428 1-421 15-435 HTECD94 1943 527210 1-318 15-332 AI025190, AL137266, AC005071, AC005488, AC004878, and AC006014. HTECD88 1944 527214 1-342 15-356 AA804334, and AW007980. HTECD70 1945 527203 1-324 15-338 HTECD65 1946 533795 1-328 15-342 HTECD56 1947 527209 1-178 15-192 HTECD15 1948 523029 1-402 15-416 HTECC71 1949 508142 1-370 15-384 HTECC45 1950 508124 1-317 15-331 AA406427, H66890, H64867, H66639, H69191, AA693972, AA410436, AA931060, N38830, H48140, AI247909, AA251684, N23377, N76083, AA887276, T61107, AW328038, AI681235, AW328039, AA608986, H72100, N71448, AA188574, C02442, H70867, R94076, AA394213, AA487534, T68446, AC005185, AL121877, AC006039, AL121578, AC006458, AC005544, AC005014, Z84481, AP000261, AP000100, AP000035, AC004696, AC002094, AC008040, AC005774, AC006157, AC005284, AL049834, AL080250, AC006150, AF048727, AL022393, AC004448, AC007001, AF129077, AF165147, AC008009, AC004202, AP000518, AC002383, AB023054, AP000692, AC003119, U91325, AC006355, AL031542, AC005853, Z69722, AL031315, AL035461, AF011889, Z83826, AC004975, AC008085, AL022318, AC004664, AC005862, Z76735, AC004746, AC007286, AP001101, U80460, U91324, AL133162, AP000075, Z97180, AC002531, AC002511, AC003034, AL135922, and U95738. HTECC26 1951 508144 1-403 15-417 AA393147, and AA398551. HTECC09 1952 678659 1-353 15-367 AA306529, AA306591, AA826008, AI089960, AA887528, AI333816, AA513786, AA524465, AI125407, AA541685, AA446158, AA315157, AI185832, AA603451, AI660483, AI871796, AI138696, AI563976, AI141745, AI479416, AI304867, AA938482, AI342761, AA281870, AA102814, AA586819, AA526476, AW157657, AI878833, C14084, AI515670, AI879393, C15292, AA931242, AA125855, W19566, AI081138, AA248470, AA070996, D59838, AW138570, AI660905, AA442677, D60576, AA776763, AI038860, AA527168, AI879973, H72163, AI096871, AA887522, AA535032, N29179, AA437187, C15125, AW163651, AA100697, AA070617, AA126067, AA682431, W21262, R58065, AI217985, W95562, H64391, H91983, AA352582, N53018, AA125841, AI356704, AA927737, AI336049, AA889266, AW272440, AA502617, AA431548, AI184304, AA833674, F35247, AA369535, W39436, AA281586, AA575968, W95435, AI056604, AI350076, C14543, AA878900, AA947125, W15344, AI537988, C15570, AI085201, AA732059, AI184964, AI569557, AI301035, AA429855, AI889555, AA513631, AI000301, AA592946, AA317358, AI797215, AA722721, AA758447, AA721039, AI339315, AA947500, AI149920, W37085, AA682224, AA962818, AA552223, C15228, AI073583, AI051738, AA737832, AA303269, AA548883, AA991817, AI869608, AA923511, AW297214, W07566, AI222563, AA991676, AI301328, AI376085, AI080573, AA364733, AI031902, W04779, AA878574, AA600861, AA779628, AA091291, AA322774, D81321, AI039006, D60527, AA782434, AI202852, H89937, AW192683, N80835, AA356010, AA301770, AA304243, AA129809, H91874, AI198092, D60707, T93983, N20273, AI271711, W24482, D60706, and AA369534. HTECC08 1953 960439 1-341 15-355 HTECA44 1954 508135 1-427 15-441 AW086066. HTECA39 1955 508132 1-408 15-422 HTBBP54 1956 728811 1-736 15-750 R62332, H17378, and R25901. HTEBO43 1957 715704 1-304 15-318 AI928432, AI291335, AI803224, AI298002, AI985197, AI924618, AA489696, AA489695, AI806154, AW138014, AI241232, AW291969, N36798, AA436451, AA765512, AA743624, AA020798, AA848065, AA436498, AI221817, AI768422, and AA015614. HTEBM87 1958 503275 1-278 15-292 AA383834, AA383833, AW117332, and AW268492. HTEBL53 1959 578544 1-355 15-369 AA383796. HTEBJ02 1960 921321 1-408 15-422 H73473, and AA383702. HTEBH09 1961 870732 1-560 15-574 AI204211, AW274576, AI285857, AA383617, AI394396, AA442838, AI218526, AI214386, AA781925, AA725598, AA758847, AI671527, and AI125254. HTEAX06 1962 960792 1-413 15-427 AW300891, AW182267, AI002121, AI393590, AW268430, AA812869, AI363725, AI937132, AI370331, AA431750, AA383228, C20655, and AI537879. HTEAV22 1963 679394 1-449 15-463 H16258, AI362696, AA159083, AI337351, AI049674, H05276, AI963664, AA612853, AA421018, R50945, AA398617, AI276451, AA868365, and AA383003. HTEAU39 1964 503295 1-428 15-442 R45446, AA994896, AI285099, AI419926, AI219508, AI650680, R41613, AA383142, AI264406, AI942371, and AC005752. HTEAT17 1965 667184 1-298 15-312 AA416657, AA394107, AA629341, AA382909, AI075928, AI150321, AI204602, AW022487, AA397912, AA862555, AI066604, and AA442269. HTEAS02 1966 921323 1-527 15-541 AI203924, AA383061, AI215017, and AA861908. HTEAR93 1967 503298 1-361 15-375 AA383056, and AA383057. HTEAQ55 1968 732562 1-1106 15-1120 AI979276, AW117497, AW269774, AA701653, W46209, AA778787, AW269767, AI218590, N20493, W28100, AA039403, AA781351, AI025502, AI696076, W26315, AI281715, AA088596, N25525, AI220590, AW136955, AA758981, AA406069, AA972182, AI634149, AA628118, AI819755, AI215556, AA039283, N33500, AI218587, W46210, AA382922, AI476428, AI766748, AA724549, AA723963, R84858, R85787, AW087598, AW275213, C20812, and AC004805. HTEAJ96 1969 503533 1-421 15-435 AA382756, and AA382755. HTEAH75 1970 503546 1-324 15-338 AA382618, and AA382617. HTEAG47 1971 503623 1-411 15-425 AA707221, H91075, AA677780, H90565, AA382495, AA382494, and AI825267. HTEAG08 1972 960469 1-322 15-336 AW298466, AA382538, AA504454, and AA382537. HIBAB50 1973 724751 1-310 15-324 AA459803, AA382330, AW084476, AW118229, AA770485, AI393130, and AA894604. HTEAA04 1974 925522 1-533 15-547 AA431127, AA432144, and AA382138. HSWBY36 1975 708291 1-413 15-427 AA993042, and N22565. HSWBT69 1976 867537 1-366 15-380 W25339, AA046193, AA449279, and U36384, HSWBE29 1977 412991 1-394 15-408 AI034154, AI075224, AI273184, AA912285, AI950513, AI885608, AI335673, AI887898, AI080389, AW243126, AA912258, AI656815, AI869093, AA743734, and N62780. HSWAS65 1978 953051 1-391 15-405 AI149166, AW134820, W74519, AI126334, AI458127, AI702779, AW241716, W74520, AI313414, AA325604, AI085318, AA028905, AI809343, AA927327, AA621660, H18963, W79859, and U87223. HSWAS18 1979 666302 1-481 15-495 AI341837, H29745, AI744756, R86286, H27353, and C02105. HSWAR63 1980 471236 1-343 15-357 AI368388, AI375597, AI333175, AI096336, AI143097, AI371774, AI863007, AI143646, AI401020, AI264622, AI955198, AI830291, AI871932, AI089379, AI361917, AI669393, AI083964, AI130018, AI284009, AI763092, AI313424, AI860304, AI761302, AI802694, AI689622, AI807536, AI889890, AI283822, AI984147, AI436614, AI831700, AI401294, AW166231, AI373088, AW440862, AI283398, AI628021, AI076054, AI160352, AI356262, AW303797, AW027683, AI076901, AI750565, AW138762, AW205241, AW131274, AW182727, AI633329, AW027104, AI826608, AI131379, AI082361, AW051864, AW007685, AW148788, AW015247, AI309293, AI761146, AW152138, AI917165, AI094866, AI991300, AW055285, AW189932, AW167782, AI819815, AI660514, AW152227, AI192788, AW138854, AW026436, AI625376, AI493229, AI435865, AI141874, AI140238, AI559315, AW205065, AW139124, AW205019, AW089459, AI147674, AI142533, AI283228, AI524717, AI985076, AI418837, AI452497, AI084650, AA761057, AI352600, AI365199, AI359053, AW134846, AI281009, AI189810, AI927109, AI475646, AW008134, AI347476, AI127254, AI798042, AI245694, AI084053, AI472105, AI858658, AI346716, AI805265, AI056708, AI168084, AW168327, AI335542, AW016943, AI763091, AW080734, AI344496, AW001416, AW134801, AW138795, AW139783, AW134778, AI083683, AI436570, AI356539, AI913071, AW291502, AW205777, AI364682, AW135748, AI805245, AW118495, AI378537, AI751342, AI017678, AA731725, AA743409, AI284044, AI367653, AI244522, AW129260, AI274414, AI336615, AI521300, AW206154, AI817686, AA768889, AA687148, AW204642, AW067873, AA748715, AW206063, AI344202, AW204658, AW134471, AW134992, AI498998, AW272093, AI751403, AI184103, AI365388, AI868143, AW029417, AI096546, AI193953, AI274606, AW068441, AW149182, AI475878, AI884460, AJ056487, AI242557, AW075326, AW058138, AI956107, AA934582, AW087680, AW277100, AI937167, AW086079, AI992000, AI040279, AI440481, AI290523, AW103911, AI266204, AI383396, AI636832, AI872349, AI092810, AI382023, AI471042, AI745657, AW082335, AW207085, AW079700, AI991258, AI934795, AW150946, AI359264, AI797905, AI244599, AI205545, AI985061, AI952709, AI250781, AW170789, AI916414, AW150829, AI290207, AI208838, AI824627, AW137667, AI916148, AW169534, AI439477, AI126922, AW138184, AW139537, AI369691, AI018609, AW028207, AI858490, AI282372, AW014680, AI500554, AA775869, AW014451, AI123239, AI553795, AI554710, AI350901, AI241918, AI865208, AI274094, AI366682, AI379191, AI144370, AI417103, AI990960, AI871260, AI264233, AA533302, AA654830, AI284364, AW205575, AW207168, AW089185, AW137590, AI873120, M11167, M11120, M27830, U13369, X59734, AJ270046, M29181, X02995, X59733, X82564, X00525, V01270, AF061798, AF061799, U17964, U17965, U17962, U17963, J04633, AF074093, S48220, U34339, U34337, U34341, U34342, U34340, U34336, AF061800, U34338, L15286, AF132045, U67616, AF086136, D86039, AF061797, AR016103, A85605, A85520, A86292, A65652, E08821, A71562, AF059516, X59474, S78388, A22946, and L20636. HSWAQ31 1981 697856 1-405 15-419 AI621111. HPWTA06 1982 936026 1-611 15-625 AA197067. HPWSA52 1983 727294 1-336 15-350 H87580, and AL035699. HPWDK45 1984 839559 1-521 15-535 R05355. HPWDF03 1985 924978 1-701 15-715 W87370, AI168586, AA678331, T96677, W87371, and T96792. HPWDE86 1986 785710 1-362 15-376 R34114, and R62645. HPWCJ90 1987 789170 1-385 15-399 AA036882, AW073808, AW006251, AI992106, AI089385, AI095532, AI143143, AI979301, AI750308, AW001022, AI147683, AA046259, AI598152, AI201784, AW235719, AI696115, and AA011669. HPWCG85 1988 638155 1-1025 15-1039 AW172969, AA601278, AA469230, AI376239, AJ609972, AA847704, AI431434, AI249365, AA601680, AA829065, AI053934, AL042539, AA857812, AI281818, AW089016, AI620992, AA169245, AW089322, AI282629, AA480486, AA704101, AI446623, AA609834, AI859438, AI340151, AA130647, AA622479, AI912401, W60522, AA904211, AA491767, AI783911, AA563770, AA487142, AA992562, AI961983, AI417469, AW264901, AA828047, AA828867, AI133083, AA911590, AA484892, AI224583, AA573062, AW408767, AI279417, AI061313, AA704393, AL041970, AW407632, AL046519, AI445224, AA197019, T47138, AA578832, AI445934, AI053597, AI054418, AW303872, AI417464, AA587826, AA487645, AI500552, H38769, AA176605, AI355559, AA701105, AI636734, AI277373, AI613465, AA362349, AI989408, AA598605, AI355246, AI733856, W63553, AI598060, AI049931, AI243793, AW341955, AA985201, AA468956, AI762528, AA632765, AI189682, AA683279, F23338, AW105729, AI598056, AW157616, R91827, AA515631, AI362552, H95769, AI206841, AW410409, H71678, AC005740, U80017, U95090, AC006312, AC005696, AC005412, AC002565, AP000044, AP000692, AC005529, AP000113, AL035587, AL079304, AC004819, AF111169, AP000045, AL121603, AL035249, AL031311, AL031670, AL139054, AC005051, AL021546, AC005288, AC005071, AC005730, AL021878, AC004492, AP000555, AC004983, AP000112, AL035086, AC005952, AC006211, AP000330, AL021391, AL031657, AC005620, AP000557, AB023049, AC002094, AC004491, AC002115, AC005971, AC007792, AC006111, AC007057, AL024498, AC004765, AC002316, AC007707, AF196969, AC005225, AC005940, AC007226, AC000353, AL022238, AF053356, AC002350, AD000092, AC005837, AC005839, AB003151, AC004796, AL096701, AC004596, AC005037, AF165926, AC020663, AP000501, AC002312, AP000959, AP000140, AC005231, AC005067, AC004991, AR036572, U91328, AL078581, AP000031, AC005031, U78027, Z98946, AF001550, AL022318, AF045555, AC005776, AC005480, AL080243, AC005874, AF134471, AF001549, AF134726, AC006241, AL050307, AC005409, Z84469, AP000212, AP000134, AC005914, AC004953, AC004910, AP000350, AC006088, AL035457, AL049759, AC007363, AL109627, D84394, AF111168, AC004531, AL031846, AC007216, AL034420, AC005803, AC004662, AC005049, AC007686, AC006049, AC005180, AC003007, AL133445, AL034429, AC006130, AL031281, U47924, AC005625, AC007298, AL031431, AP000553, AL035659, AC007666, AC006965, AL022326, Z93930, AL049795, AC006011, AC005695, AC002126, AC002302, AC005911, AC005324, AC004019, AF207550, AL035422, AJ003147, AC004185, AL049709, AC005666, Z83840, AC006285, AL031255, AF064861, AC006543, Z82244, AP000228, Z83845, AC006120, AC004854, AC005200, L44140, AC002477, U52112, AP000058, AL079295, AD000812, AL109801, AC006449, AL031284, AC005520, AL022320, AC004167, AC004253, AC005057, AC003029, U95739, AL021154, AL049692, U85195, AC005829, X87344, AP000248, AL050341, AL132712, AC009516, AF088219, AC005102, AC006360, AC005082, AC007283, AC007308, AL008718, AC000052, AC004832, Z83826, U91326, AL096791, AC006480, AL020997, AC004929, AC005089, AF030453, AL034548, Z95114, AP000558, Z81369, AC002425, AL034423, AF196779, AC007450, AC004448, AF196971, AC002404, AC006581, AC004000, AL031584, AC006544, AC005800, AE000658, AC005484, AC002470, Z93244, AL117337, AC005527, AC005358, AL109798, AC002091, Z86090, AL022302, U91318, U96629, AL022721, AC005280, AC004158, AP000695, Z82203, Z85987, AC007421, AC006254, M89651, AC006538, AC003963, AC007277, AC006255, AC005632, AC007227, AC005722, AC006501, AC002551, and AP000513. HPWBF35 1989 707514 1-219 15-233 AA136312. HPWBE47 1990 720563 1-532 15-546 T61306. HPWAT23 1991 676323 1-277 15-291 W31570, and AF136745. HPWAJ85 1992 535157 1-326 15-340 AI681684, AI458401, AI936264, AW055212, AI200740, AI635739, AI973110, AW044010, R60842, AI690626, AA281860, AI823929, AI142509, AA781250, and Z95115. HPWAJ39 1993 575271 1-202 15-216 HPWAJ05 1994 932627 1-551 15-565 N76233, and R18040. HPWAH19 1995 468246 1-483 15-497 AI671077, AA506744, AI859744, AF047825, AL049757, AC005529, AL022721, AC004491, AC005823, AC005081, AC005527, AL132712, AL022316, AF001549, AC002312, AC002477, AC005015, U95742, AP000952, AC005488, AL035587, AP000501, AL021155, AC003982, AC006511, AF111168, AF109907, AC007216, AC000353, AC000003, AC005484, AC005037, AC008372, AC005837, Z93023, AL035450, AF088219, AC004675, AC004253, AL049761, AC006241, AC005911, AL139054, AL031848, AC009516, AC007227, AC005740, AC005694, Z99127, AC005666, Z95114, AC007993, AC005736, AC002470, AC002549, AC006430, AC005899, Z85987, AC002400, AC005225, U47924, AC002310, AC007686, AL080243, Z93017, AC005940, AC005696, AJ246003, AC004125, AC002072, AF111169, AC006277, AC004685, AC006254, AC006547, AC006312, AC005924, L78810, AC007225, AC003108, AP000555, Z84466, AP000553, AC002365, U52112, AC004841, AC005412, AC005565, Z84469, AC005291, AL109963, AL034420, AL021546, AP000694, AL121603, and AC006121. HPWAG31 1996 693618 1-271 15-285 HPVAH71 1997 829301 1-378 15-392 N59310, and W26272. HPVAH41 1998 848632 1-658 15-672 AW084140, AI660275, AI159785, AA931541, R46761, AI017335, H69563, AI253649, AL046863, AI718728, AI860915, AA421105, AA780157, AA622029, AA564314, T85269, AI187002, H93474, AA862619, AA860857, N51712, AI092970, AI093731, AI288177, AA725376, AA397987, AI632608, N95238, AI383237, AW273559, AW014246, AW025440, N75603, AI089430, H84661, AI074224, AA877282, T96893, AA430388, AA994095, AA577687, AI962794, AW071881, AI147145, AA627632, AA757265, AI348280, AA292692, N62956, AI022266, AI039833, AI332399, N63622, H92137, AW452472, AA452012, W94925, W95270, N80289, T67556, AI800953, AI524405, AA937741, AA946602, AL046862, AI202094, AI471911, AW362569, and AF161509. HPVAC74 1999 773298 1-623 15-637 AI803004, H82351, AI912547, AI684625, AI093039, AA043382, AI700890, AI016549, AA043383, AA789239, AA868305, T03714, AW449266, and AI990568. HPVAB16 2000 526124 1-199 15-213 AW183886, AW295375, H73304, and AA455018. HPVAB01 2001 961017 1-340 15-354 AI123463, AI025472, AI827469, AA916957, H86257, AI457871, AA748446, AW295278, AA058998, AA888811, AW293429, AA047229, AA012881, AI738469, Z65045, and Z65044. HPRTJ65 2002 753933 1-616 15-630 AA193128, and W24151. HPRTI54 2003 728812 1-542 15-556 H80993, T58115, and T58181. HPRTJ16 2004 667652 1-540 15-554 AA454985, AA232735, AA454986, W25444, AW303344, and AI368936 HPRCV66 2005 320393 1-543 15-557 AW450541, Z43026, T96106, and AC007377. HPRCT83 2006 780264 1-470 15-484 AA032184, AA152299, and AC007182. HPRCN03 2007 925420 1-513 15-527 AI074020, AI187913, and AC004056. HPRCM12 2008 973740 1-582 15-596 Z81007. HPRCL72 2009 766311 1-234 15-248 N53915. HPRCI73 2010 764710 1-325 15-339 AA594588, and AI821697. HPRCG46 2011 719340 1-450 15-464 H17732, AA195383, AI268825, and AA609857. HPRCD11 2012 967762 1-377 15-391 H63477, AW386067, and AC003006. HPRCC22 2013 526623 1-258 15-272 AL135490, AA460352, AI538075, AA635150, AA661590, AI926876, AI921744, AA557945, AI040051, AI144125, AA600202, AI049999, AA578245, AA112646, AA720732, AI344906, AI318548, AA640305, AI620666, AW341903, AW270258, AA469230, AA595661, AL135357, F00564, AA846923, AA482682, AA555232, AI910608, AA847095, AA767660, AL044966, AI749823, AA483606, AA570740, AA831714, AI568376, AA568204, AA430137, AW104161, AI753904, AA857296, Z36862, AW419227, AA045734, AA584241, AI434653, AA846944, AW021674, AA501410, AA086042, R95840, AW270385, AA505012, AI572680, AI079154, N72170, AA229113, AI279693, AW021116, AA493546, AI523356, AI821608, AI803824, AA191418, AW192419, AA828758, AL048275, N66775, AA367986, AW020094, AA164946, AA828840, AA994578, AI357762, AA808875, T57562, T41235, N23913, AW404543, AA862243, AI433952, AA872299, AA502532, AA804726, AA345665, AA573003, AA493245, AA568433, AA653139, AI926104, AA523718, AA584148, AW021399, AA601376, AI003391, AW057760, R99617, AA713946, AA714956, AI249683, AL120708, AW165963, AA826134, AA828771, AA558402, AA558716, AA582554, AW272815, AI590404, AA631915, AA018207, AA487053, AI754257, AA302661, AI984168, AI791426, H66812, AI732473, AA525112, AA659360, AA749235, AA706291, AA182731, AL079553, AI356440, AA828802, AA828781, AA653672, AL035587, AC005601, AC007014, AC004953, AC002310, AC003966, AC006057, AC005488, U91326, AF198095, AC004531, AC003663, AF111169, AC001228, AL121754, AC003042, AL133245, AC005815, AL031589, AC004099, AC003688, AC009247, AC005899, AC007225, AL031595, AC005895, AC005913, AL008725, AC002425, AC008040, AC006312, AC005305, AL109963, AF124523, AP000359, Z84469, AC005726, AL117258, AC008134, AC002045, AC004765, AC005067, AL109628, AC005763, AC002036, AL022320, AL121657, AF154836, AC006064, AC005971, AB023049, AC005082, AL020993, AC004659, AC006080, AL050308, AL049776, AC004895, AC004448, AF217403, AC005519, AC005037, Z99289, Z97054, AF109907, AC016025, AL109801, U62293, Z93023, AC000085, Z98950, AL121653, AL117340, AC002470, AL049780, AC005081, AC004797, AC006449, AL135744, AC004858, AC009516, AC004000, AC005089, AL109952, AC006285, AP000255, AC005231, AC004796, AC005527, AC004150, AP000065, AC004771, AL132994, AC006511, AC003982, U63721, AL031666, AC005005, AC002404, AC007363, AC005304, AC004408, AC002472, AL031588, Z98750, AL133353, AP000213, AC005015, AP000345, AC005529, AC004832, AC007686, AF165926, AP000135, AL034402, AC005274, AC004493, AL031230, Z97353, M87914, AL022323, AC007066, AL021939, AL117330, AC007298, AC006958, AC004020, AL035420, AC006017, AP000031, AL035659, AC004009, AF069291, AC002554, AC006557, AC004834, AC004381, AL049766, AP000501, AL049843, AL022331, AC002544, AC005570, AL078581, AC020663, AC000052, AC006160, AC008498, AC005339, AC005914, AC005257, AL022158, AC005736, AC005911, AC005624, AC004019, AC005844, AC004673, Z95327, AC007664, AC008055, AC007917, AF187320, AL034419, AC007041, AC004962, AL022237, Z98949, AL022313, Z99716, AB022785, Z82190, AC004605, U43572, AC004458, Z82189, AB003151, AL021940, AL109967, AC004927, AC005972, AC004687, AP000553, AL021391, AL096701, AC004656, AP001053, Z93244, AC004905, Z84466, AC004887, AC012085, AC004703, AL133448, AF207550, AC005531, AL136168, AC003109, AC004821, AC000079, AC004230, AP000555, AL035405, AP000211, AP000133, AL031311, AC003098, AL109837, M84472, AL109657, AC004598, AC005412, AC004801, AF001548, AL049830, AC002492, AC002558, AL078602, AC002996, AC004841, AC006211, AL050338, AC004685, AL034421, AF196779, AF196969, AC002565, AL049760, AL008582, AL080243, AC005618, AC006277, AC000134, AC005280, AP000347, AC005829, AL022315, AC005969, AC002073, AC003101, AL096707, AC004859, AL136295, AL133371, Z93017, AC007021, AP000356, Z93241, AL096677, and Z98051. HPRCA02 2014 917289 1-376 15-390 AA564925, AI904944, AA666295, AW151247, AA972523, AA102737, H62923, H86579, AI624551, T05617, AA984920, AL044271, R77715, T94072, AA468974, T05684, AA230025, AA468371, AA228979, AA229823, AA484892, AA228368, AA224889, AA468505, AA228269, AA772704, AL137946, AA402113, AW243945, AA593828, AA467943, AI671077, AL041815, AA614254, AA224815, AA720582, M85967, AA664248, AI801563, AW419126, AA181479, AA888638, AL038533, H93152, AA550959, N27874, H81012, AA502110, AA714110, AA558404, AI278211, AI560073, W24312, AA612578, AA298647, AA890060, AA377325, AA745628, AI819391, T71936, H54252, R99076, AL118912, AW105463, AA581525, AA780933, AI369076, AA322484, AL047467, AA747977, AA550989, AI668605, AI567391, AI306717, AA548221, AA302978, H94979, AW242279, AI249688, T07878, AA329535, AA773463, AA631729, AL041681, AA482792, AL041682, AA630854, AI500315, AF031078, AF030876, AF031076, AC006344, X05151, AC005899, U07563, AL033539, AC001226, AC004983, AC009946, AC003002, AL022336, AP000207, AP000129, AC004112, Z82215, Z73913, AL049712, Z93023, AL035457, U52112, AC005207, AC000090, AC005157, AC005186, AC005089, AC007312, AL133355, AC004961, AC005841, AF196971, Z93017, AL024498, AL035661, AL122020, AC012627, AC006014, AC004593, AC005488, AL031282, AL023575, AC007371, AF111168, AL031003, Z49237, AF124730, AB014077, AC000387, AC004209, AP000514, AC000003, AC004686, AC004241, AC003963, AL035461, AL133247, AC005212, AC005393, AC005484, AC003015, AL031587, X87344, AJ246003, AC004539, AC006034, AL049758, AF064863, AC010200, Z68284, AC005856, AP000289, AP000042, AP000110, AC002073, AL096791, AC004770, AC007436, U91321, AC007934, AL121658, Z83844, AC006387, AL022330, AC004032, AC005751, AC004963, AL136504, Z82976, AF001552, AC007666, AF109907, AL034347, AC007040, AC005372, AC002365, Z68276, AP000261, AP000035, AP000100, AC005911, AC004022, AL022395, AC005343, AC004531, AC005252, AL121782, U73479, AP000096, AC004223, AC005588, Z86090, AC007279, AC006023, AC007565, Z86064, AP000503, AC005067, AP001058, AC005829, AC002369, AC007639, AC004159, AC002538, Z98941, AC010205, AC005409, AC005874, AF134471, AL135744, AC004953, AP000355, AC009542, U35114, Z85986, AL049795, AC005620, AC004865, AL031657, AC005011, AC004673, AC004858, AL023553, AF048729, U62631, AC006080, AF134726, AC005726, AL031295, AC003998, AF205588, AC005280, AP000691, AL049569, AL031186, AD000092, AC004887, AC005045, AC004477, U91319, AL008734, AC006445, Z70280, AC002468, AC006367, AL009031, AC002326, AC005412, AP000223, M57678, U96629, AC003689, AC003043, AC006468, AC010170, AC000115, AL008721, Z97632, AC002040, AL035414, AC005913, AC005919, AL121769, AC004805, AC004815, AC005837, AL139054, AC003101, Z49258, AC005101, AP000303, AP000046, AP000114, AC004585, AC005695, AC004388, AC006515, AF064866, AL031311, AP000502, AC005300, AC002395, AC006965, AC007536, AL031885, AL021917, AC006076, AC005383, AL032821, AC006211, AC005375, AC004035, AC005362, AC007205, AC004663, AC005884, AC004941, AC002402, AC006270, AL133163, AL133500, AC009330, U85195, AC007406, AC005041, AL022163, AC004890, AP000690, AL050341, AC006262, AC004460, AL031666, AP000689, AC004886, AL035413, AP000553, AC009516, and AC004491. HPRBN23 2015 467480 1-442 15-456 HPRBJ87 2016 695116 1-229 15-243 AA148577, AA371499, AI190166, AW182200, AW450886, and AL080125. HPRBH80 2017 781636 1-395 15-409 AA371425, R08248, W78735, AA002229, AI034386, and AC004582. HPRAV80 2018 781637 1-574 15-588 AI796794, H16396, AW450892, H06067, AA885838, AA370953, R40187, Z38928, F01486, F02763, and F04922. HPRAN56 2019 503140 1-455 15-469 W55957, AI379296, AI191798, AA987330, AI688094, AA001362, AI655136, AI277583, AW235235, AI080751, AI341857, AA936711, AA907791, AA001353, AW002519, R00840, AA370556, AA897172, and R01496. HPRAN50 2020 724753 1-334 15-348 AA370553, and AA370552. HPRAJ75 2021 766496 1-351 15-365 AA370391. HPRAG73 2022 764757 1-734 15-748 W94997, AA370226, and AF123462. HPRAG45 2023 484691 1-268 15-282 AA370201, AL031295, AL096775, AL034548, AL022323, AL049757, AL117258, AL021707, AP000031, AC003982, AC009516, AP000359, Z95115, AC002538, AC005031, AC005519, AP000135, AP000557, Z83844, U80017, AC005406, AC005261, and AC004983. HPRAF86 2024 784594 1-219 15-233 AA369988. HPOAB37 2025 789290 1-526 15-540 AI670779, AA384366, AA687253, AA505096, AA732524, AI525876, AA461291, N50753, AA461408, AI095123, AI393841, AI141520, and AA522490. HPM5H94 2026 796839 1-599 15-613 AA214535. HPM5B35 2027 707476 1-245 15-259 W05600, and U47671. HPMMK05 2028 928283 1-824 15-838 AI312886, AA709064, R25113, R25114, AI271454, and AW131860. HPMMB08 2029 957945 1-679 15-693 N57273, AA975894, AA078184, AW271847, AI720195, C13996, R67746, AI469577, AA322542, AI580260, AI926706, AI338117, W60077, AA865083, AA663975, W01985, AI039539, H72865, AA747234, W04464, F07235, AI253290, AA604201, AW270771, AI277347, AA492527, AI039125, AI266359, T65747, AI581433, D44787, T78912, F02611, H58207, AA577754, AA297195, AA630122, AI884861, AA160427, AA481811, AA721530, AA363003, AI288033, AW243945, R51217, AA721523, AI678581, R56848, AA078137, H01327, AA745351, F10272, AA161198, H67098, R67701, AA745383, H11450, AA484419, AA484370, AA678616, AA664248, AW270429, F35684, T90962, AA668166, AW270351, AA714073, AA491423, T05617, AA018895, AA478518, H01243, AA376358, AA780933, AI366993, AI859906, AI278847, AI915081, H71449, AI869786, AI679221, AA167550, N63848, T30418, AA457408, AW019964, AA309362, AA013366, T07903, AA345594, N77384, AA679353, AA302520, AA665908, AA772873, N57674, AA457254, AI927261, AL134418, AL031670, AF044083, AC005972, AC002395, AL136295, AF075066, AC005243, AF001550, AC007684, AL133289, L16854, Z82189, U52683, AC006360, U89336, L35668, Z49236, AF135187, AC007292, Z84489, AC007421, AL021579, AC005377, AC005383, AC007240, Z99572, AC005612, AC005620, AL133246, AC007406, AC007283, AC004476, Z99130, AL009183, AC000015, AL031115, AL008635, AL035587, AC004134, AC006000, AC006014, Z82214, AC005099, AC000378, AL035653, AC004552, AL133396, AL020995, AL049646, AL079304, AC005325, AC004887, AC006079, AC005488, AC005041, AC007207, AC003037, AF003626, AL109662, AC004186, AC002451, AL049766, AC000045, AC004811, AL008725, Z97630, AC002550, Z82244, AC005067, AC005231, AC006597, AL031291, Z98742, AL022326, AC005875, AL049759, AC007130, AL035415, AC007314, AC006316, AC012331, AC003665, AC004448, AL008723, AC005799, AL035091, AC005921, AC005747, AC007327, AL031681, AL021937, AC008126, AC005261, AC009509, AL031733, AC004382, AC005348, AP000517, AB023054, AC006251, U96629, L29766, AC004792, AC002984, AC004791, AC002316, AL033523, AL022166, AL034379, AC007041, Z82182, X54486, X13922, AL139054, AC006064, E12647, Z49155, AC004693, AC005759, AC002309, D87013, L48038, Z82208, AC005778, AP000300, AP000563, AC002390, AC006958, AF042484, AC004814, U07563, AC004938, AC004771, AP000113, AP000045, AP000133, AP000211, AC005800, AL049610, AC004703, AL031622, AC004929, AC007128, AC004991, AC005060, AC006509, AF030453, Z83822, AC002554, AC003106, AL132712, AL021154, AC003663, AL096773, AC006044, AC002476, AC005969, AC006026, AC006011, AC005535, AC007395, AC005088, AC004674, AL096701, AC004491, AL133238, AC005722, AC005042, AL049776, AC005291, AC005516, AL133244, Z95114, AC005015, AC005406, AC000353, AC005914, AC005225, AP000688, AC004650, AC004775, AL035420, AC005014, AC007349, AC007637, AC004623, AC004961, D84394, AC002480, AC004796, AL133445, AC004983, AP000130, AP000208, AC007955, AL049832, AP000247, D87009, AC006501, AC007792, U47924, AF037338, AF091512, AC004453, AC005209, Z98304, AJ003147, AC007011, AC001231, AC005082, AC002375, AL008734, AL021578, U95740, AC006013, AL033527, AC005412, AC005193, AC007198, AL135746, Y17293, Z68756, AC002054, AC002472, AC007664, and AC008018. HPMKP06 2030 933895 1-328 15-342 AA436495, AI801028, and AB002353. HPMKC05 2031 930874 1-501 15-515 R97706, and Z73979. HPMJT12 2032 969483 1-663 15-677 T84974, T91224, R00550, and R00654. HPMTN08 2033 958009 1-377 15-391 R06344, AW452106, AA729350, AL031295, AL122023, Z99128, AC007637, AC007298, AL022166, AC007917, AC004779, AL008635, AC007151, AC018633, AF109907, AL022721, X55448, and L44140. HPMJK11 2034 965636 1-504 15-518 H54909. HPMJK03 2035 867615 1-493 15-507 AW193499, T41385, AA325521, AA417987, T05187, AW440956, AW439999, AA907133, AI000677, AI537915, AI791144, AA844107, AA287035, AW298615, AW088364, AI537814, AA715387, AA523882, AA687547, AI302974, AA121818, W46473, AI798234, AA906440, AL120129, AW148336, AA484366, AI801031, AA308708, R55092, AI821120, AI688963, AI821864, AA018440, AI660071, AA334287, AA069926, W27874, R96138, AI811076, AA767864, AA227741, AC011594, AC006538, AC002126, Z68871, Z68281, AC004156, AL133500, AL031230, L13972, AC004812, AL034423, AC002400, M61107, U62317, AC005067, AC003663, AF111170, AF059321, AL049758, AC004104, AF155238, AC005803, AP001065, AC004703, AC002365, AC007279, AC002394, AP000365, AL031686, AP000547, AC002565, AC005049, AC007263, AL022721, AC006966, Z97630, AC006509, AL0503 18, AC004887, AC003098, Z85997, AC007868, AL031295, AC004253, AC004890, AC004876, AC002558, AC004916, AL009181, AC002116, AC002984, AC002070, AP000555, AC005578, AC004674, AC005323, Z95331, Z93930, Z82206, AC009263, AL022476, AF196970, Z95115, AC006125, AC002551, AF114156, AC006157, AP000104, AC003982, Z98044, AF121781, AL031280, AC004985, AC005015, AP000344, AL049779, AL022336, AC004814, AL031681, AC003013, AC004962, AF061032, AC000085, AC002425, AC005519, AC005880, AC007040, AC002524, AL034400, AC004149, AP000510, AP000345, AC008042, AC005520, AB023048, AC002036, Z73964, AC009533, AL132777, AC004991, AP000270, AJ011932, AC003684, AP000032, Z82195, AC006360, AC005800, AL121852, AC000086, M63543, M63544, AF181897, Z84487, AC005821, AL049569, AC006026, U95740, AC002464, AF050154, AC007229, AF020802, AP000687, AL035414, AC004383, AL117694, AC004990, AC002312, AC003950, AC002985, and AC004084. HPMJI11 2036 965627 1-487 15-501 AI244898. HPMJE06 2037 939682 1-575 15-589 AI022159, and AI240345. HPMJA11 2038 965628 1-446 15-460 H85685, H82116, H85672, and H92336. HPMGX92 2039 491004 1-561 15-575 AI733856, AI627614, AA587728, AA573722, AI133083, AI354333, AI270370, AI524193, AA458452, AW194325, AA683069, AA491423, R67701, AI049999, AA614163, AA513851, AC007055, AC005527, Z83844, AC005529, AC007792, AC006026, AC004832, AF196971, AP000355, AF111168, AC007371, AL049757, AC002477, AC005488, AC005531, AC006441, AC005015, AC006139, AC002565, AC005500, AC005837, AP000555, AL022721, AC007731, AC005071, U47924, AL121603, AB026898, AC005902, Z82244, AC000025, AC007386, AL117337, AC005049, AL033527, AC004895, AC005164, AC005011, U78027, AC005291, L77570, AC005696, AC007546, AL109627, AC005180, AF130342, AL133404, AC008044, AC006039, AL121658, AL049776, AC006064, AL079342, AC007541, AL096791, AC004448, Y18000, AL035405, AP000014, AL049839, AL078638, AF029308, AC004890, AC005971, AC004882, AC004991, AC004815, AC007842, AC004525, AL035681, AC005081, AC009247, AL035659, AL049643, AL133448, AF139813, AL049872, AL049829, AC004966, AL132641, AL024507, AL034420, Z94802, AL139054, AL049843, AC005484, AC007919, Z83822, AC004973, Z84487, AL049576, AC005899, AL035420, AC005005, AL031680, AC002347, U85195, AC005225, AL022320, AP000307, AD000092, AL050307, U80017, AE000658, AL135746, AC002073, AF205588, AL122020, AC006013, Z92542, Z84484, AC011311, AC003101, AC005066, AL135744, AC005519, AF067844, AF064861, AL035587, Z93241, Z81357, AC007051, AL121653, Z84480, U91318, 798750, AC004531, AL031685, AC005037, AL021578, AL031846, AC003025, AC007349, AC000026, AC004985, AL133445, AC005859, AC002470, AF038458, AC004583, AC005295, AJ251973, AC007878, AC002059, AP000113, AC007201, AC005932, AC005378, AL023807, AC002115, AL021937, AF134726, AL008730, AC005702, L44140, AL109758, AF019413, AC005215, AC007283, AC004019, AC002299, AL117694, AC005581, AC007216, AP000502, AC002558, AC005231, AC008101, Z97055, AL022237, AL022238, AL133245, AL049748, AC007666, Z75407, AC005057, AC005736, AC004686, AP000503, AC007686, AC005255, AL035462, AL008719, Z98048, AC005523, Z95118, AC007993, AC004167, Z82188, AL031283, AC007030, AC007227, AJ246003, AC003084, AP000115, AP000694, 793020, Z85987, AC004217, AC006040, U73169, AC007011, AF165926, AC004821, AL035071, AC004382, AC004228, AC005632, U82828, AC005368, AC007688, AC005740, AC006974, AC007845, Z94056, AC000066, AC004653, L78810, AC007384, U52427, AC004876, AL021154, AC006071, AC006059, AC004526, AC002996, AC006455, and AC005920. HPMGR15 2040 660374 1-429 15-443 N95527. HPMGO88 2041 463906 1-460 15-474 N66134. HPMGM39 2042 705460 1-1424 15-1438 AW027268, AW299861, AI057303, W01903, N80342, N91193, AA010796, N68397, N64546, AA011135, AW194796, AA133637, N71008, AA393085, AI284257, AA133638, AI017033, H12527, AA412114, R27162, AA365161, W01706, N58095, and AI288082. HPMGJ16 2043 662021 1-214 15-228 AA297666, AI219169, AA228459, AA503119,AA829576, T07039, AI732869, AI821987, AA707849, AW250905, AI799327, AA489571, AA516047, AA626823, AI610376, AA381750, AI500453, AA424438, AI244157, AW179306, AC005015, AC006271, AC007637, AC002310, AC005484, AF207550, Z99943, AP000066, Z93016, AC006120, Z97053, AC007237, AC005666, AC005280, AP000466, AC007308, M89651, U50908, AL133485, Z93017, AC003043, AL035461, AC005088, AL109801, AP000353, AC004477, AC004223, Z75887, AL008718, AC005067, AL022312, AC007938, AL133448, AC006141, AL022163, AL109984, AC002470, AC006511, AC005091, AC005899, Z98749, AC007285, AC003684, AC004962, L81691, AL009183, AL121653, AL049869, Z94056, AC002996, AC012384, AP000030, AC006441, AL109865, AC003007, AC004491, AL031427, AC002365, U85195, Z86090, AC002544, Z93241, AL034429, AE000658, AL031311, AC006480, AL049748, AC007055, AC002527, AL049635, AL022336, AC003982, AC006251, AL031005, L78810, AC005479, AC003665, AP000550, Z98050, AL096701, L34079, AL031722, AC005089, AC010077, AC008018, AC003111, AL132712, AC005971, AC005632, AC005225, U80460, Z84476, AC005102, AC004975, U95740, AC002395, AC005722, AC003663, AF069489, AC006059, AC005326, M87923, U95742, AC004973, AC006039, AC006211, AC005412, M63480, AC018769, AC001231, AC002425, AC004262, AC004882, Z83849, AC006450, AP000505, AL022165, AP000694, AL035684, AD000092, AC005034, AC006312, AC005901, AC006257, AL035398, Z93783, AC005377, AC004983, AL133246, AC004895, AC005670, AF117829, M63544, AL022313, AL021368, AC005291, AL023807, AL031670, AC005324, AC002476, AB023049, AC006505, AC008009, AC004076, AC006501, AC005332, AC006160, Z99716, AC007435, AF109907, AF129756, AC007283, Z81369, AL031432, AL133245, AL049843, AL008735, AL023096, AL008730, AC010170, AL024498, AL080243, AC005753, AC005874, AC004922, AF134471, AC006965, AC004020, AC005261, Z81314, AF196971, AC005005, AP000512, AL023803, AC005755, AC006581, AL031283, and U91322. HPMGD63 2044 694518 1-682 15-696 N59650, Z40592, F02367, and AA480778. HPMFX29 2045 690704 1-616 15-630 W84490, W84350, AL044564, AI972017, AF086479, AF097027, AF097026, and AC002992. HPMFL73 2046 867670 1-717 15-731 AA773011, and AF047825. HPMFC02 2047 920327 1-904 15-918 AI361020, AI806300, AI339924, AA972324, AI689765, AI141310, AI798724, AI005122, AW015619, AI002107, AA721275, and Z59058. HPMFB26 2048 867674 1-348 15-362 AA736385, AA262258, AL022164, AC005520, and AC007559. HPMEG77 2049 772503 1-397 15-411 AA178897, AA178882, and AA179898. HPMDQ89 2050 880787 1-444 15-458 AI634152, AI624814, AL135959, and AL049631, HPMDP10 2051 968350 1-415 15-429 AW002399, AW450136, AI624994, AW082789, AI936619, AI953139, AA923323, AI377859, AI808017, AW452164, and AL109754. HPMDF06 2052 954567 1-114 15-128 W28809. HPMAM93 2053 791407 1-361 15-375 R42698, AI921147, AW001714, AA985608, AW025311, AI367373, and AA369641. HPMAL77 2054 772740 1-628 15-642 AA149508, H66540, H53279, R99964, and AA369352. HPMAL73 2055 764752 1-155 15-169 AA369348, AA018792, and AI439103. HPMAK71 2056 503690 1-428 15-442 AA369278, AA369277, AA368633, AA297498, R86114, R92608, AC008101, AC016830, AC005736, AC006252, AC002477, AL024507, AC016027, AC006205, AC005303, AL035458, AL031683, AC004966, AC005695, AL031295, AL035682, AC005082, AL008729, U52112, AL109764, AC007350, AR036572, U91328, AF003529, AL049839, AC006213, U95742, AC004477, AC002369, AL035420, AC004916, AC005666, AC007371, AF111168, and AC007216. HPMAJ83 2057 781518 1-396 15-410 R10536, and AA369467. HPMAJ50 2058 572808 1-331 15-345 AA369413. HPMAI10 2059 968695 1-202 15-216 AA303040, AA369200, F18842, AA535216, N23913, F17700, AA489939, AA603530, AI281818, AA829044, AI349580, AI682665, AI884383, AA659608, AA633762, AA385798, AI538658, AL047349, AA993818, AI537458, AI251429, AA463590, AW088745, AI439910, AA837035, AL041894, AA633920, AI354564, AA701080, AW068316, AA584125, AI087040, AA376760, AA639946, AA312303, AA372949, AA679794, AA502818, AI054333, AA661499, AI753113, AA302969, AI814739, AA449997, AL079734, AI453714, AA994578, AW023111, AA608751, AW085623, AA947269, AW079664, AI382324, AI537424, AA984187, AW084246, AW402458, AA621838, AW149156, AW302017, AA722039, AA904137, AA613624, AA601356, AA452906, AI933714, AA714322, R92983, F31380, AL119600, AW410354, AA483381, AA362714, AI056177, AI798493, AW188976, AI583321, AI207424, F16133, AW268277, AI383057, AI053911, AI925491, AA338262, T57767, AA779783, AI590593, AA847622, AA484370, AA484419, AI860587, AA811208, AA157458, AA601327, AW196014, AI254779, AA282820, AA083003, AA084609, AW073510, H45698, AI754037, AA579208, AA558404, AI002941, AA078337, AI054352, C14692, AA715173, AA206132, AP000695, AC007999, AC006333, AC005565, AC004659, U91326, AC005666, U63834, AC005821, AC005015, AL031311, AL022323, AL050307, AC002544, AC002477, AP000556, AC005069, AC005399, AC005412, AC003100, AC005803, AC003959, AC005602, AP000114, AL035495, AL135744, AC005011, AC007731, AJ229041, AC005500, AC003665, Z95118, AP000512, AL049636, AC005387, AC000134, AL049757, Z95114, AC005225, AC004821, AC004386, AL034423, AC004883, AL049776, AC008015, AB023049, AC006241, AC004228, AL035659, AC005081, AP000557, AL133448, AC004253, AC004263, AC004408, AC007279, AC007327, AC006538, AL109984, L35676, AL021394, AC004655, AC008394, AL031258, AC004167, AC005612, AC004491, U82828, AC005940, AL022165, AC005837, AB023050, AC006441, AL022318, AC005022, AL031589, AC007225, U41483, AC002418, AC005920, AC005759, AF017104, Z84480, Z93244, AL035684, AC005206, AC004232, AC006141, AL121748, AC007056, Z98044, U33956, AC005207, AC006050, AL035086, AF165926, AC005519, AL023584, AC005696, AP000511, AL023807, AC009516, AL031296, AL021391, AL033525, AC004472, AL121603, AC005695, Z85986, AC002551, AC005667, AP000502, AF111168, AC004148, AL049692, AL049869, U95742, AC018633, AL132774, AL034417, AC003982, AC004587, Z97353, AC003035, AL022476, AC003669, AC007308, AC007216, AL008726, AL022721, AL133289, AL133396, AL020993, AC006285, AC005535, AP000696, AC004900, AC005755, AF190465, Z69707, Z98750, AF134726, L44140, AC005049, AC002300, Z83826, AC005377, AL034420, AF002223, AC003684, AL050348, AL050325, AL049795, AL133163, AL031587, Z98946, AL031295, Z99496, AC002400, AC005899, AL024507, AC004895, AJ246003, AP000212, AP000134, AC004884, AC004049, AC008125, AF047825, AC005368, AC005875, AF207550, AL035420, AL132712, AL080243, AP001053, AC005921, AC007238, AC007388, AL022171, AP000555, AC004851, AL121754, AC007899, AC004605, AC004019, AL022345, AP000350, L78810, AL050332, AC004622, AL050333, AC005209, AL023804, AL023284, AC005233, AC005988, AL021407, AC011422, AC005740, AC003037, AC004647, AC005566, AC000039, AC004966, AL078603, AC005597, AP000303, AC005295, AC002301, AL136295, AD000684, AC005089, AC005531, AC005529, AC004067, AC004993, AC005005, AC006055, AC004771, AL031846, AC016025, U07563, AC002128, AC005082, AC005736, AC004000, AC002310, AC004051, AC005520, AF031076, AC005971, Z95115, AC007073, AF064861, AC007845, AL008721, AC005288, AC005324, AC006079, AL031733, Z93023, AL121654, AL133353, AP000011, AL035443, and AC003071. HPMAH85 2060 783344 1-436 15-450 N24966, and AA369334. HPMAH56 2061 867711 1-378 15-392 AI969185, AA369304, AA369303, AC002404, AL034417, and AL133163. HPMAB10 2062 968723 1-538 15-552 AA400632, AA400317, AA513753, AI188727, AI148002, AI797479, AI090223, AI833007, AA676886, AA740345, AA536076, AI336523, AI191303, AA978356, AI017725, AI128273, AA639692, AA468753, AA724081, H27059, AI879456, AI500369, N41692, R07494, AA252085, AA368986, AI436367, AW363134, AA838338, AA947905, AA707248, AA199605, AA670492, AA633704, AA931186, AW081785, AI554783, AI432454, AA927473, AI886832, AI886932, AA542849, U75998, F34689, AI970899, AI865318, AI142293, F26406, R07547, AA811357, AI815926, AI815728, AA353038, and AI831322. HPLBW22 2063 679217 1-271 15-285 AA101449, and AA368833. HPLBW02 2064 921331 1-501 15-515 AA644353, AI305162, and AA368822. HPLBT54 2065 731065 1-524 15-538 R77180, and AA368801. HPLBT53 2066 728517 1-436 15-450 AA429609, AA368800, Z68274, and AL117391. HPLB541 2067 712707 1-546 15-560 W69937, W69806, AA368743, and AF086311. HPLBQ96 2068 796069 1-208 15-222 AI950844, AA970836, AA368531, AI761793, AW071107, R68649, and C00439. HPLBO90 2069 787208 1-352 15-366 AA404593, AI732819, AI821540, AA459410, AA368625, and AA404736. HPLBN79 2070 781854 1-313 15-327 AA368571, AI565323, AI479183, and N49068. HPLBB47 2071 975477 1-733 15-747 N40247, AA467841, AA467897, AA368245, AI017480, AA973025, AA860186, AA305650, AA305127, AA307746, AW067937, AW299379, AC005881, and AL023280. HPLAX14 2072 727885 1-500 15-514 W69552, AA368102, R50327, W21480, AA477047, AW383764, AA356448, AA368997, AC005071, AF161081, and AF161080. HPLAV44 2073 715732 1-481 15-495 H53753, AW386067, AA367999, H63477, and AC003006. HPLAI10 2074 968707 1-562 15-576 AI128337, AA572738, and AA367352. HPJFA10 2075 963322 1-594 15-608 AI810835, and AI817587. HPJEV95 2076 929723 1-515 15-529 AA159265. HPJEU01 2077 928408 1-359 15-373 R19571, AA468022, AA583898, AW364981, AI872020, AW276817, AA469451, AA828749, AL119691, AA169263, AA502860, AI110688, AA501821, AA580808, AI801600, AW303196, AI699710, AW274349, AA665021, AA362698, AA806796, AA724333, AA508034, AL042853, AA507824, AI284640, AA548058, AI247199, AA812139, AI305766, AI053790, AA581903, AI634384, AW193265, AW103758, AI963720, AI635279, AW301350, AL044858, AA521323, AA299761, AA521399, AA533725, AA513141, AW084252, AI345157, AI476312, AW440545, AI687343, AW028392, AA984708, AA584167, AI061334, AI270117, AA531079, AA491814, AA714453, AA448231, AW438643, AA525824, AA452563, AA847952, AW062682, AA828042, AA618452, AI564454, AL138265, AW002350, AW265009, AI144101, AA372481, AW419237, AW327868, AA774222, AA808877, AA623002, AA720702, AA523837, AI355206, AI350211, AA219115, H85842, AI311557, AI619997, R97780, AA576336, AI149478, AA490183, AA480772, AI017415, AI686267, AA541423, AA634889, AI908381, AA613397, AA610491, H73082, AI860013, AL045053, T74382, AA478355, AL046409, AW440497, AI110760, AA604333, AI289067, AA781010, AI754658, AA715255, AA715267, AA483771, AL043009, AI281881, AA551503, AW273218, AA826671, AI307608, AW302903, AA468456, AI536665, AA653375, AA658362, AA503154, AI801482, AW274346, AW168618, AI240168, AA702614, AA577906, AI445674, AI624142, AI783494, AI345518, AA351056, AA494097, AI885249, AA828677, AI633390, AI669453, AI744995, AI207496, AA782304, AW276827, AW410400, AI537955, AA847499, AW149339, AW265170, AW157608, AW269488, AI568678, AI054343, AW196064, AA552843, AI583283, AA788982, AW050498, AW088202, AI434695, AW276435, AA573003, AA610271, AW270382, AA954924, AW268973, AL045808, AL046156, AA664909, AA620525, AI744188, AL119713, AW238278, H18959, AI499588, AI357288, AI821271, AI357212, H63262, AI085719, AI814735, AI003751, AI246119, AW080125, AW408047, AL038705, W79504, H66632, AA220943, AI828208, AW264934, AA405453, AI254316, AL079511, AL049869, AL035462, AL078474, AC005911, AC003977, AC007564, AC005288, AC007308, AL132716, AC004884, AC005091, AC002470, AC005212, AJ239318, AC004655, AC004531, AC011421, AC003009, AC005376, AC008275, AC006312, AC005037, AF003528, AF029308, AC005274, AC004883, AC004814, AL133353, AL023284, AL022147, AC018633, AC005839, AC005082, AC007686, AL049647, AC004538, AC006270, AL008725, AC006037, AC007099, AC004690, AC005324, AC007919, AL133321, AL022165, AC008079, AC004894, AC005028, AL121578, AC007226, AJ003147, AF015153, AC006238, AL096701, AC004167, AC004622, AC010168, AC004832, AF036405, AL121603, AC002429, AP000567, AC005411, AC015853, AC002064, AC005531, AC002452, AL031651, AC007750, AL109847, AL031682, U69569, AC007151, AC007731, AC004544, AP000049, AF130342, AC005224, AC007051, AC002310, AC004905, AC004216, AL049697, AC006360, AP000311, AL049825, AC005180, AL121658, AC007450, AP000275, AL049556, AL022322, AC004587, AL049696, AF130351, AC007751, AC004010, AC005614, AC005820, AC003950, Z83846, AC008040, AC005246, AL031681, AL049757, AC005019, AC006207, AP000105, AP000037, AC004848, AF015148, AC005191, AC004584, AB020859, U67211, AP000043, AP000111, AC004975, AC004028, Z99716, AL035587, AC002430, AC007041, Z98744, Z83826, Z49235, AL031255, AL009029, AC004686, AL050333, AP000556, AL109985, AC004943, AC007537, AC000085, AC003962, X55933, AC003109, AC005154, AC002365, AC007384, AL079303, AC004913, AP000095, AL035458, AL078593, AC007165, AJ229042, AC005871, AL137100, AL031285, AF165926, AF042090, AL132992, AC006254, AC008055, AL049795, AC005015, AC002067, AC009411, AC002379, AL031733, Z98745, AL035681, AC008115, AC005225, AC005412, AC000025, U35114, AF161800, AC005193, AJ006996, AL031589, AC002041, AJ246003, AC004994, AR036572, U91328, AC003691, AL136018, AC004838, AP000239, AL031277, Z54246, AC004796, AP000953, AC003665, AC008127, AC004098, AC002565, AC003684, AF112482, AL132799, AF165138, AP000432, AC005772, AC004562, AC005235, AC005230, AC006004, AC005488, AL035423, AC005678, AC006155, AL109829, AC007207, AC002476, AL049776, AC004019, AL078603, AC007064, AC016025, AL031577, AL031230, Z69719, AC000004, AC004033, Z69917, AL096771, AC004638, AC006130, AL022302, AC006597, U47924, AC004895, U95742, AC006241, AL031904, AL022724, AL021155, AC002564, AC005011, AL078581, AC007285, AC002402, AF146191, AL109865, AC007676, AP000352, AC004057, Z98753, AP000555, AC006482, AP000965, AL021154, AL049832, AL035530, AC007632, AC006026, and AB023051. HPJET11 2078 965894 1-588 15-602 N62272, and AI049662. HPJE517 2079 859867 1-426 15-440 AI469935, AA035546, R54113, T27117, and H41850. HPJEL02 2080 918315 1-318 15-332 AA001172, and AC006987. HPJEG53 2081 974074 1-505 15-519 AC006137, and AC007160. HPJDW93 2082 867759 1-715 15-729 AA213989, and AW016127. HPJDT03 2083 922815 1-388 15-402 AA446260. HPJDP54 2084 949149 1-287 15-301 AA621949, and AI935081. HPJDF61 2085 889928 1-757 15-771 C14389, AA360910, H81346, D80195, C14014, D51423, D81026, D50979, C15076, D80164, D59467, D59502, D59275, D80193, D80227, D80038, D80166, D58283, D80022, D81030, D59859, D59619, C14331, D80210, D80391, D80240, D59787, D51799, D80253, T59438, D80043, D80269, D80212, U82828, AC005668, AF036405, AL096867, AC005300, AL050306, AC007688, AC008044, AC007052, AC004967, AC005071, AC004913, AL031666, AC007276, AC006509, AJ003147, AP000502, AL109657, AC003041, AC005529, AF023268, AL080243, D88547, AC004990, AC020663, AC003071, AC004223, AC005829, AF053356, AC005821, AC004150, AF134726, and AC010206. HPJDC01 2086 915056 1-470 15-484 AI279943. HPJDA25 2087 951281 1-572 15-586 AW408615, AI815752, AI906637, and AF047690. HPJCU29 2088 928407 1-615 15-629 AW339568, AA525000, AW087208, AI284640, AA350859, AI471481, AA649642, AW276827, AW193265, N25296, AA469451, AA829223, AL046409, AI061334, AI049634, AI35021 1, AW193432, T07451, AI688846, AI289067, AI341664, AI431303, AA491814, AL041412, AI613280, AI887483, W79504, AI619997, AI375710, AI340453, AI754658, F36273, AA664535, AA134367, AI345654, AI017024, AI344844, AI963720, AI814735, AA594145, AA568778, AJ830390, AA394271, AW338086, AI064864, AI281881, AI334443, AA551503, AI053672, AW303196, AW274349, AA810370, AW438643, AI446464, AA831375, AF150152, AI871722, AI298710, AA630030, AA714453, AA598824, AW301350, AI623898, AI133164, AA719805, AW410400, AA652764, AW166815, AW029038, AL041690, AA126051, AA126035, AA610491, AI434695, AI537955, AA526342, AI754955, AW406162, AI379719, AI888008, AI085719, AA486414, AI270117, AI962050, AA652057, AI801600, AA771811, AI708009, AI732186, AW303876, AW162049, AI929531, AA598586, AI610159, AA713815, AW265009, AA470969, AA581903, AI821271, AW276817, AI679782, AI133102, AW088846, AW439558, AA191620, AW269488, F29989, AI339850, AI291268, AI291124, AW406755, AW419262, AA521323, AI282832, AL044940, AA513181, AI567674, AW302013, AL138455, AI341548, AI110770, AI471543, AI133636, AA522942, AA582911, AA644538, AI251002, AI499134, AI963095, AA862173, AA730684, AW339687, AI358343, AL038785, AW265385, AA491831, AI151261, AI499938, AF150222, AA634146, AA682912, AI358229, AI281697, AI367497, AW008317, AI160117, AA587604, AW104748, AA542991, AI357551, AL138265, AA678436, AI287651, AA323749, AA649705, AI561060, AL120674, AI745325, AL048925, C05986, AI148277, AI859742, AI625244, AI761471, AW270270, AI457397, F19012, AA084070, AL119691, AI281903, AW440836, AW406447, AI143242, AA623002, AA602528, AA837084, AW272758, AW157005, AI937850, AA111909, AA531372, AI801591, AI365988, C75026, AA569387, AI669453, AW162489, AW088058, T06828, AA644551, AA487858, AA665742, AW008952, AA569205, AA071144, AA148489, AA348311, AI469003, AI590689, AI590958, AI262909, AA302963, AA599920, AI279165, AA703820, AI371070, AI951889, AI245679, AI653886, AI866908, AW148792, AI471487, AI561255, F23205, AI801482, AI873916, AA577906, AL120687, AA837351, AA729721, AI744995, AA521399, AA992126, AW071196, AA977743, AI683577, AW276435, AI539563, AI828208, AL079645, AI570261, AI917271, AW243960, AI635818, AA721981, AI469624, F01314, AI028510, N25042, AA492166, AI624142, AI749559, AI569086, AA488395, AW103758, AL049610, AL031283, AC004522, AC004901, AC005033, AL050342, AC006544, AL022161, AC004953, AF001549, AC002558, AL035541, AC004070, AP000244, AC007221, AC018769, Z84484, AL035494, AC004703, AC006543, AL022323, AC005821, AC003098, AC005829, AC005839, Z98941, AL031735, AL049554, U92032, AC002412, AC005482, Z84478, AC002300, AC009069, AC007240 AL109611, AC006559, AL034424, AL022320, AL080241, U69730, AC003690, AC004817, AC005682, AL035420, AC000086, AL008638, AL024498, AC007242, AL049611, Z82202, AL049692, AC004551, AC000003, AC004605, AC005901, AC002289, AC003003, AC005988, Z75889, AC000124, AL031681, AC007966, AC003669, AC002407, AC005086, AC002288, AF047825, AP000077, U95739, AC003035, AC005751, AC008008, AC005736, AC006059, AC003049, AC004870, AC011456, AL110503, AL022068, AL132642, AP000946, AC005566, AL021307, AC009802, AL049632, AC006958, AC005244, AL023283, AL008639, AC010175, AC002287, AF179633, AC005632, AC006079, U51559, AC006960, AC004832, AC018633, AC006537, AP000010, AC002492, AF049895, AC004931, AL109939, AC006112, AF191069, AF096876, AC006479, AP001046, AC004690, AL079333, AC003964, AL133162, AP000127, AP000205, U62317, AL008720, U91321, AP000073, Z84489, AC002429, AL022326, Z94865, Z95331, Z97184, AC007541, AC004019, AC004967, AC006153, AC005531, U66059, AL110122, AL049833, AP000459, AF165147, AC005741, AC004948, Z82188, AL021877, Z95152, AC000353, AL035681, Z95115, AC007114, AC005815, AC005778, AL096712, AL034549, AL035419, AC007298, AC005089, AR036572, U91328, AC002395, AL080243, Z84814, AP000512, AF068862, AC005696, Z86061, AC002477, AC006505, AL035250, AL049744, AC002115, AC007068, AC002457, U47924, AC005245, AP000253, AL034451, AL023581, AC005019, AC004659, AF029308, Z97989, AL049569, AC004990, AC008101, AL033376, AL031650, AL049745, Z85987, AC005046, AL121593, AP000952, AC005274, AP000213, AJ003147, AP000135, AC004638, AP000031, AC006057, AL035588, AC004848, X54180, AC002375, AC004884, AF015154, AL121748, AC007319, AL049539, AL049829, AC005323, AC004453, AL109981, AF111168, AC002094, AP000495, AL022311, AL021808, AL031778, AC004047, AC005859, AL121603, AC000397, AL121591, AL023281, AL031319, AC007243, AL022163, AC005041, AC002400, AC004455, AF134726, Z69838, AC005412, AL034553, AC007682, AC006441, U62631, U91326, AC004837, AL133245, AC008064 AC007091, Z68872, AC007934, AC005940, and AC006430. HPJCT81 2089 494874 1-401 15-415 T47764, AI240418, AI042373, AI680840, and T23659. HPJCT26 2090 559949 1-628 15-642 HPJCS73 2091 975087 1-540 15-554 AC009533, and AC008013. HPJCS43 2092 715082 1-426 15-440 HPJCS32 2093 699046 1-261 15-275 HPJCN60 2094 887600 1-408 15-422 AC005754, and AF152495. HPJCL55 2095 670083 1-580 15-594 AA460600, AA971933, AA461528, AI028767, AW104221, AA916255, AI807812, AA815321, AA609716, AA897273, and AA382975. HPJBU40 2096 710928 1-411 15-425 T79399, T79485, and AC004460. HPJBU09 2097 625362 1-520 15-534 H14685, H11846, and Z42042. HPJBS74 2098 765390 1-579 15-593 AA199800. HPJBS52 2099 726535 1-505 15-519 R69458. HPJBS35 2100 867818 1-427 15-441 R08072. HPJBL76 2101 769889 1-764 15-778 N20501, W21595, AA971971, AI017087, AA782105, AI924135, and AC007066. HPJBL30 2102 948721 1-1114 15-1128 AI743553, AI458005, AA855142, AI808388, AI808190, AA854848, AI167631, AI458852, AI740975, AI184926, AI027358, AI084343, AI041477, AA860979, AA782086, AI864309, AA585255, and AL035562. HPJBK25 2103 974606 1-199 15-213 HPJBK14 2104 974593 1-317 15-331 Z98272, and AC005202. HPJBH45 2105 717088 1-391 15-405 H02676, R21208, and AC006480. HPJAX30 2106 607408 1-748 15-762 HPJAU73 2107 806718 1-306 15-320 W04456, H09371, D59238, H09370, N34243, AA091691, and N75681. HPJAP92 2108 887830 1-416 15-430 Z97832. HPJAO13 2109 824243 1-895 15-909 AI284640, AI801600, AA745582, AA491814, AI350211, AA745431, AI902694, AW080134, AI053672, AL133723, AW193265, AI688846, AI446464, AA492132, AA985038, AA747480, AA350859, AA318652, AI286356, AI471543, AI679045, AA649642, AI610159, AA503258, H64777, AA515435, AI761471, AI469624, T07451, AI281697, AI251002, AI205126, F25276, AA977743, AA515751, AA559290, AI281881, AW419262, AI610376, AW276435, AA678436, AA747276, AW088058, AW274349, AI648558, P29989, AI061334, AA605274, AA747472, P36273, AI962050, AI287651, AA553465, AI264743, AI344844, AI198376, AA377730, AA483034, AA650244, AA469451, AI312149, AI049634, AA745560, AI918421, AI471481, AW103981, AI937850, AA490165, AI768952, AA659083, AI367975, AA594145, F18974, AI245679, AA364224, AA365302, AA680243, AI286264, AI624698, AW440976, AA441788, T40338, AW236342, AA521323, AA557879, AA843450, AW265170, AI287964, AW029038, AL046409, P31204, F28776, F37169, H64560, AI305547, AW193432, AI339850, AI963720, T53607, AI929531, AL120483, AA347927, AA708678, AI282832, AI358571, R91994, AI904894, AW243960, AI358343, AW243698, AI184226, AW166815, AA657918, AA515051, P23279, AL045182, AI355206, AW264973, AI919029, AI431303, F33566, AW276827, AA347930, P37286, AW303196, AA886584, AA244415, AI206785, N43757, AA302963, AA482711, AA338486, AI270117, AA501722, AA229785, AI821271, AA503154, AA669840, P35673, AA557686, AI653905, N71930, AW272758, AW301350, AA358122, AA654771, P34558, AW104748, AW406755, AA664535, AA100372, AA084070, AA810318, AW265654, AA364456, AI924251, AW261871, AA682912, AW088202, H41319, T08638, AI619997, AW162049, AI832782, AI633007, Z98473, AA581903, AI358501, AA669251, AA394271, AI365988, AI569086, P28576, AI083946, AI963095, AA610491, AI866956, AI299050, F28204, T06783, AW238278, AI692265, AI802526, AI358229, AA515224, T40617, T29180, AI083998, AL119691, AA528516, AI309740, T40077, F26152, C75026, AI709365, AI133636, AI081095, AF150152, AA715609, AI567674, AC004076, AP019664, D83989, X75335, AC007446, AC005598, U57007, I51997, AL031680, AL008725, M87916, AP000297, X55925, U57009, U14718, U80017, AC009498, Z30979, M37551, AF015152, U18394, AP001035, X55928, X54180, U18391, U18392, U57006, U18393, U57005, U18390, AL049776, S75337, M87919, AC005546, U18399, S70697, X55924, U18398, AL035448, Z81370, AC006942, AL031118, X55932, AL023553, AC005291, AL109801, AC006205, U18395, AC006537, AC005032, AC005790, AC005335, X54181, X54178, X55931, U57008, AC006251, X54175, S70707, S70694, U02058, U02054, U02063, Z93016, AC005028, U14716, AF147277, AP000044, AB020859, AP000112, AB024685, U14719, U14713, AL031577, AC007386, AL035458, AC005284, AF077058, AC003954, U14710, AC002038, X55922, U14714, AC005019, X55926, AL031650, Z75888, U18387, X55930, AC005912, U14711, U14712, AC011198, AC005614, U95740, U14706, AP000306, AC005193, AC007298, Z94721, U14695, U14705, Z75887, U14702, U14689, U14691, U14685, U14686, U18396, AP000047, AC007370, AB023057, AC002564, U02048, AC009069, AP000520, AC005565, D26067, Z84474, M87918, U72787, AC007216, AC005251, AP000115, AC005815, AC000387, U14715, AC004020, AC004263, AC005069, D87000, U14703, S70699, AL031427, U95742, AL022154, U47924, AC008115, AB020668, S77605, AF055066, AF015156, AC006208, X54179, U14699, U14687, U14688, U14692, AP000553, AL139054, AC009516, AC004964, AC006211, AC004193, AC004659, AC005071, AL132992, AC002404, AC004957, U62292, AC001164, AP000567, D89870, A39972, AC002544, Z85987, AL133404, Z92845, AC005250, AC008079, AF139813, Z82195, U14717, AL034553, AL110120, AL031714, AC006285, AC004990, AC005592, AL031054, AL035209, AC006336, AL023513, U67221, X54177, AL035450, AC007099, AL035551, AL050318, AC004453, AC006204, AC004854, Z98744, AC004638, AC007012, AP001172, U18400, AF015160, Z84814, AC004637, AL031602, AC005838, AC004813, AC004019, AF015153, Z98043, AC004878, AC006152, AC005360, AC004765, U63721, AC003982, AC004187, AC006511, AC005071, AL034549, AC006207, AC005104, U14700, AC010436, AC005993, AC004152, AL021546, U14690, AL049633, AC004890, Z31005, Z82208, AF015155, AP000252, AL133399, AC005670, AC007312, AC007243, AC008101, AC007043, U73684, AL021977, AC004477, AL121603, AC007617, Z75746, U34879, U91326, AL034548, and AL049781. HPJAN69 2110 754858 1-346 15-360 HPJAN67 2111 751384 1-308 15-322 AA961913, AI088134, AW263056, AI923972, AW205741, W19869, AC004962, and AL049431. HPJAN57 2112 734503 1-239 15-253 AL133246. HPJAJ20 2113 669000 1-754 15-768 R11971. HPJAE51 2114 725761 1-564 15-578 H16572, AW241811, H18666, AW241812, AW129128, AW009414, AA553981, AA876116, AI243349, AA757971, AL035696, AC004842, AF020802, AP000687, AJ229041, AL035252, AC005908, AL009179, and AL022324. HPJAA27 2115 419786 1-348 15-362 E17067, and E17068. HPICG93 2116 887817 1-434 15-448 HPICE06 2117 935095 1-804 15-818 H97402, R51737, N69864, and N24204. HPIBY36 2118 708183 1-504 15-518 H08396, R25790, N53251, N51204, Z42071, and AP001115. HPJBT62 2119 743135 1-475 15-489 R23515, N76536, T74959, F12749, AI961429, F11571, and AA640294. HPJBO89 2120 786741 1-459 15-473 H96715, W90749, R49610, AA983768, AA904877, AA677746, R38813, and AL133095. HPIBI89 2121 867845 1-426 15-440 R99003. HPIBH31 2122 838809 1-428 15-442 H73369, N34255, AW160399, H79944, AW239079, AA132425, R20300, H73299, N30499, AW407963, H70394, R97376, W52852, AA182911, AW407596, AA302225, N43927, W19497, T70776, W31972, N42142, T85051, N23533, AA093843, AA305409, AA312807, AA045678, W80575, AA326688, AI245848, AA035464, AA329750, AA229940, AW175673, W07289, AA332809, AI631124, AA372693, R07414, AW407906, R57473, AA299454, AA455701, N55991, AA230126, H03161, AA223846, AW205900, H96200, AA364785, AA467792, AA035465, AA307572, AA024761, C00198, W76420, AA176320, AA120782, AI719711, AI719084, AI453530, AW162019, AW173349, AI984009, AI088520, AA639784, AA127810, and AL024498. HPIBC93 2123 785971 1-426 15-440 AI814342, AW001123, AI924201, AI935359, AA888820, AI366738, AA665651, AW134874, AA252373, AA766826, AI198343, AA670436, H42655, H62371, AI763375, Z97630, AF077740, Z79834, Z79925, Z58542, and Z58541. HPIBB45 2124 867850 1-165 15-179 HPIBB43 2125 715037 1-234 15-248 HPIBB32 2126 698901 1-172 15-186 AL021366, and AL050332. HPIBB19 2127 668489 1-405 15-419 HPIAW91 2128 790033 1-713 15-727 AI690139, AI697496, N91409, N69381, AI695286, AC004200, AP000519, AB023056, and AF055066. HPIAV06 2129 935111 1-373 15-387 AA600329, AI061271, AI609972, AA573000, AA551268, AI580707, AA665532, AI306717, AL138199, AA502207, AA302661, AA295865, AA295874, AA838091, AA378489, AA779783, T40629, AA601343, AA577824, AA665187, AI520967, AI452836, AA526424, AA553579, H25938, AA599080, AI417586, H47201, AA318116, AW084173, AL037777, AA349606, AA320521, C16718, N94325, AW236288, AI494417, R70884, AA099840, AL137946, AI921706, AA172191, AA349937, AL041375, AA719523, AI819391, AA262752, AA009855, AA551400, AA468196, AI932900, AA552966, AI570943, N91711, AA468247, AA810154, AA552202, AA137274, AL042373, AI889579, AA659656, T94140, N75708, Z97353, AC007707, Z98941, AL034429, AL109984, AL132642, AL035685, AC007934, AP001038, AB023048, AL035106, AC022517, AC004259, AC004967, AL132987, AL021395, AL035457, AB023050, AC003035, AC005095, AC012085, AC005940, AC004912, AL022577, AL031733, AL034555, AC003667, AC006432, AC004149, AL031594, AP000501, AP000036, AC005513, AC005243, AC004881, AC007381, AL031845, AP000511, AL049745, AC007242, AL035090, AC004033, AC002040, AC005823, AC007731, AP000263, AC005366, AC005500, AF037338, AC007639, AC003684, AF179633, U73634, AC007314, AC007298, AC004585, AP000100, AF126403, AC004674, AC002390, AC006313, AL031230, AC013417, AL049694, AC006312, AC006388, AC005325, AL031297, AC006080, AC005220, AC004922, AC005291, AC004814, Z83844, AC005598, AC004525, L78833, AC004228, AC004947, AC007172, AC004000, AL121578, AL139054, AL031668, AC005529, AC005071, AL034420, AL133238, AL008583, Z84487, AC002375, AC007690, AC005006, AC000003, AC005527, AF107885, U73638, AL031735, AL035086, AC004953, AC004687, AF067844, AL050325, AC005037, AC004217, AC005859, AC012384, AC005881, AL035251, AC002395, Z83840, AC005913, AC006443, AC007450, Z97054, AC008372, AC005695, AC005821, AC004876, AC006132, AP001040, AC006536, AC005304, AF053356, AL035460, AC004216, AC007349, AF045555, AD000813, AL109657, AL035659, AC007637, AF001552, AC004491, AC005067, AC000159, AF139813, AL008582, AL049869, Z84484, AC005480, AC004858, AC009516, AC007559, AC002312, AC005158, U91318, AP000279, Z93017, AL031311, AL031186, AP000152, AC007182, AC011311, AC007308, AC002492, AC005305, AF111168, AL031255, Z85986, AL031685, AC005081, AC003681, L78810, AC009405, AL035587, AC002091, AC007225, AC005245, AF017257, AB020868, AC005800, AC020663, AC006480, AC005409, AL117258, AC002369, AL008637, AL031427, U93037, Z73359, AC005015, AC002054, AF196969, AL096702, AL050318, AC006948, AP000106, AP000038, AC003030, U47924, AC002094, AC007227, AL035398, AP000512, AL035420, AC004770, AC007868, AC002470, AC005544, AC006441, AC007388, AC004812, 134294, AL035461, AL009179, AC005277, AJ229041, AC006037, AL021878, AC002504, U91321, AL031677, AC002531, AL049757, Z97832, AC005519, AC005993, AC007860, AC004883, AC002350, AF024533, AC005288, AL049748, AC002400, AC006254, AC007842, AL033518, AL031291, AC004673, AP000103, M87912, AC006026, AL035079, AL049712, Z95114, AC004143, AC006430, AP000154, AC005088, AC005923, AC000085, AC006333, and AF200465. HPIAQ70 2130 973604 1-507 15-521 HPIAP79 2131 774817 1-499 15-513 AL043020, T66111, T74122, R53143, R20480, R05568, F12380, H05013, and Z92544. HPIAD10 2132 906987 1-1270 15-1284 AA601278, AI791227, AL121287, AW069227, AI307201, AW168433, AA578621, AA587516, AW404225, AA832145, AI285578, AI309943, AI634187, AI590404, T08386, AI890794, AC005233, AL031983, AC003999, AL021026, AC006137, AC007182, AC007298, AC007685, AL079342, Z82188, AL118497, Z92547, Z68756, AP000322, AL021978, AP000121, AL021154, AC003010, AF109907, AC004887, AC003964, AL031767, AC006210, AC007388, AP000053, AP000168, AL021393, AP000362, AP000281, AC004785, AC007425, Z97205, U91328, AC004216, AR036572, AB020863, AB020868, AC005697, AC008064, AF001552, AC004858, AC004125, AL050307, AC004897, AC005057, Z93244, AC004106, AC000029, AC005228, AP000040, AP000108, AC002390, Z84467, AF152365, AL035414, AC005295, AC004455, AC007327, AC005839, AC005011, AL035608, AC007240, AC004974, AL049712, AC006116, Z86090, AL096776, AC004388, AC005482, AC005181, U95740, AP000338, AC007284, AC005252, Z68192, AC005184, AC007406, U62293, AP000216, AL034402, AF117829, AL024507, AC008040, AL022163, AL031293, AP000432, AC005291, AC005730, AC005971, AC005331, AC007263, AC004003, AL132992, AB023050, AC004844, AC004832, AL079304, AL035089, AC003006, U91318, AC005588, AL021918, AC003101, AL132774, AC005618, AC004817, AL022578, AC006032, AC005953, AC002375, AP001053, AC006167, Z95704, AF196970, AL109967, AP000511, AC006257, AC009399, AL078602, AC005027, AL031280, AL021807, AC004859, AC005838, AC009498, AC004702, AL133404, AC002394, AL139054, AL031653, Z97055, AF015416, AC006480, AC007114, AP000144, AL035420, AC009946, AL136168, AL049869, AC005102, AC006536, AC006509, AL031665, AC006277, AL109847, AC005881, AC003046, AF111169, AL133241, AC004087, AC005411, AC005036, AC004797, Z84480, AC005874, AF134471, AP000353, Z95115, AP000043, AP000111, AF002993, AC002123, AL050306, AC005534, AC006059, AC004525, AC005993, AC007546, AC004104, AC004605, AC005029, AL133304, AC005609, AC010206, AC002531, AC007656, AC002464, Z95116, AC005401, AC005013, AC003037, AC007462, AP000140, AL009051, AP000509, AC004185, AP001058, AL022237, AP000088, AC006484, AC004910, L47334, U91325, AC004975, AC005028, AL117258, AF172277, AC006075, AC004067, AC007225, D84394, AC006387, AC005049, AC004921, AL110503, AL121877, AC005799, AC005050, AC004825, AC005535, AC004838, U52112, AC004964, AP000431, AL022396, AC007541, AC007028, AL133355, AL049872, and AC004690. HPHSB91 2133 790313 1-307 15-321 HPHSB21 2134 671118 1-401 15-415 HPHSA94 2135 793084 1-196 15-210 HPHAE81 2136 778036 1-404 15-418 AI674979, AI493794, AI261833, AI478181, AW300149, AI769515, AI373263, R07018, AI672274, AW301213, AW301193, AA910740, AJ249199, and AF141289. HPFMG06 2137 933696 1-209 15-223 AA165204. HPFMB10 2138 961758 1-670 15-684 AA548727, Z28355, AI557262, AA585439, Z30131, AI557731, AI535639, AA585101, AI525306, AI557238, AI525556, AI536138, AI557807, AI541307, AI526194, AI541205, AI541365, D61254, T11028, AA585453, AI546945, AI525316, AI541415, AI541535, AI547039, AI546999, R28735, C16300, AI535813, AI535660, AI541374, D57491, AI541390, AI541013, AI557787, AI525431, R29445, AI541510, AL041346, AL041096, AL047012, AL041358, AL041277, AL041163, AL041098, AL040621, AL043538, AL041324, AL040464, AL044162, AL041086, AL043496, AL041296, AL041233, AL041140, AL040193, T23985, AA585476, AI540967, AA585155, AL040149, AA585434, AI557808, R29218, AI557082, AI557799, AI541346, AL040155, AL043444, AI541523, AL044529, AI526140, AI557602, AI557796, T18597, AL041197, AL041347, AL043612, AL045725, AI546855, R29177, AL039915, AA174170, AL040463, AL047219, AL041227, AL047057, AL047170, AL040119, AL047036, AL080031, AL041292, AL041051, AL047183, AL040322, AL041131, AL046330, R45895, AL041133, AI546828, AL041238, AL041142, AL045817, AI546875, AI556967, AL040529, AL040625, AL040510, D55233, AL043467, AL044186, AL044037, AL040091, AL040128, AL040168, AL040255, AL040285, AL040342, AL040332, AL040553, AL040617, AL045684, AL041159, AL040745, AL040370, AL043677, AL046442, AA585440, AL040839, AL041752, D61185, AL043775, AL044165, AI557727, AL043492, AL041602, AL045920, C16305, AL038838, AL040253, AL044074, AL041635, AL045990, AL040458, D53447, AL044199, AL044187, AL040090, AL040263, AL040294, AL040329, AI525856, AL040082, AL044272, AL040444, AL041186, AL040148, D59436, AL043537, AL041730, AL041523, AL043627, AL041246, AL046392, AL041374, AL040576, AL040052, AI525500, AL043845, AI557740, D59751, AL042096, AL039338, AL042135, AL044064, AL038983, AL039316, AL043923, AL043814, AL043848, AL045753, AL041459, AL043570, AL041577, AL044201, AL044258, AL046850, C14391, AL038532, AL040768, AL037727, AL044274, AL045857, AL079878, AL049018, Z32822, AL046994, AL040414, AL040571, AL046914, R28967, AI142134, AL038822, AI526184, AL040238, AI557734, AL046327, AL134524, AI541508, AL041168, AA585098, AI557763, AL049069, AI525320, AI540974, AI524891, AA283326, AL045671, T41289, AI557279, AL040472, R28965, AI546891, C16293, R28892, R28895, AI557864, AI546829, AL037335, AL039744, AL041278, AL045989, AI541027, AI547006, AL037343, D60765, AI541514, AI557802, AA585329, AL039360, AI541356, AI541534, AA170832, AL040075, AL038761, AI546996, D57186, AL041955, AI526187, AL046147, A25909, AR062871, AR038855, A85395, A85476, AF082186, AJ244004, AJ244005, X81969, AJ244003, AR037157, AR062872, AR062873, A20702, AR017907, A20700, A43189, A43188, I44681, AJ244007, AR038762, A98767, A93963, A93964, I63120, A98420, A98423, A98432, A98436, A98417, A98427, I15717, I08396, I15718, A93016, I08395, Z32836, X83865, AR008429, Y16359, A86792, A84772, Y09813, A84776, A84773, A84775, I18895, A84774, AR067731, AR054109, AJ230935, A58524, AR067732, A58523, A58522, A91750, M28262, D78345, E03627, I13349, I48927, AJ230902, A60212, U94592, A60209, A60210, I03331, A60211, AI8053, I84553, I62368, I06859, I84554, AR031566, A02712, I00682, A77094, A77095, A81878, A95051, AI1623, E00609, AI1624, D50010, AF149828, AI8050, A23334, A75888, I70384, A64973, A90655, A60111, A23633, AR007512, E13740, A70872, AI1178, E01007, AI0361, AR043601, A02710, E12615, AJ230972, AR035193, A92133, E14304, A07700, AI3392, AI3393, AR031488, I13521, AJ230951, I52048, A27396, E16678, AR027100, I49890, I44531, I28266, A35536, A35537, I21869, A02135, A04663, A02136, A04664, A91965, A95117, I44516, A70040, A82653, AR038066, A24783, A24782, E16636, AI1245, A70869, A20699, E00696, I60241, I60242, AR009151, E00697, I66485, I01995, I66487, E03813, AJ231009, I66482, I66483, I66484, I66498, I66497, I66496, I25027, AR027099, I66486, I26929, I44515, I26928, I26930, I26927, I08051, I05558, AR051652, AR051651, I19525, I08389, D13509, A22738, D13316, AB025273, AJ230867, AJ231028, AC005913, AR051957, E17098, I66495, I66494, A22734, AR064707, AR054723, AR035975, AR035977, AJ230845, AF006072, AR022273, AJ231011, AR035974, AR035976, AR035978, X55486, U87250, AR050070, A06631, X82786, S60422, AR051865, A62298, X07299, Z30183, E12584, A82595, A82593, AR063812, AR051864, I36244, AJ243486, Y14219, X76012, I05845, AR031358, AR031365, AJ230996, AJ244006, I03669, I03668, AI6035, AR017826, A62300, X82834, AR003381, I33632, E03654, AF213384, Y08991, A22739, AJ131952, AF135243, AB005666, AR009152, S68736, and L36913. HPFDX38 2139 709302 1-571 15-585 AA649151, AA251443, AW080521, AI261734, and AA761257. HPFCZ82 2140 780198 1-509 15-523 W73400, W73375, AA550828, AF086321, and AC008042. HPFCZ60 2141 430125 1-477 15-491 N27955. HPFCZ10 2142 968360 1-308 15-322 HPFCR23 2143 675120 1-432 15-446 H01127, and AI696650, HPFCP82 2144 867881 1-675 15-689 AW023111, AW021917, AI635440, AI800180, AW328331, AA714110, AI800168, AI962030, AL046519, AW237905, AI887235, AA297145, AA129746, AI792521, AA831638, AI440117, AI687343, AW270255, AI491765, AI799607, AL119691, AI821931, AW419389, AW275432, AI755057, AW008169, AI254959, AI792499, AA528503, AA773463, AW238253, AI380617, AL119247, AA456924, AI345132, AA502532, AI267269, AL037714, AW189113, AA837686, AI278972, T05118, AI753672, AI279417, AI889795, AI889804, AI732789, AA284247, AW157456, AI874341, AA433894, AW162697, AI369580, AI445934, AI912401, AL135357, AI284543, AI250552, T74524, AW168420, AW410354, AA828637, AI144055, AA397389, H38769, AA314891, AW238484, AA864603, AW407632, AA618316, AI053793, T49633, AI362442, AI560085, AI251034, AI206841, AC005913, AC007327, AL035090, AL022320, AC005082, AC004805, AL078477, AL031846, AC004659, AC007193, AC007216, AC007011, AC007363, U95742, AL023580, AC000052, AC004025, AC005022, AL133353, AC004877, AC007277, AL031053, AC007684, AL035073, AL049830, AL031186, AL031297, AC003991, AC007919, AP000080, AC007425, AC005730, AC004019, AC004531, AC004673, AF134471, AC006064, AC004796, AR038762, AL049570, AL050332, AC007151, AC007738, AL049557, AC007546, AC006153, AC004053, AF031078, AC006581, AF030876, AC005736, AF181896, AL035413, AC007051, AL031311, AC004743, AC008055, AF017104, AL022336, AC005969, Z80896, AC007857, AC004832, U85195, Z93023, U91321, AC005089, AB023048, AC002326, AE000658, AL034549, AC002395, AC004975, AC007899, AC005324, AC009946, AC002480, AL035414, AC002070, Z93241, AC005399, AC005246, AL035610, AL109758, AC007450, AC004804, AP000076, AP000962, AC003012, AC006455, AC008012, AC005771, AC002316, AC005553, AL035405, AC004 106, AL109657, AL031779, AE000660, AC007100, AL049779, AC008009, AC007436, AL031346, AC004821, AC007676, AC005696, AC007242, AC005053, AC006285, AC005071, AC004895, AL033521, AL050307, AC002465, AL035659, Z97353, AP000035, AC004540, AC003108, AL021326, AC006385, AC005529, AF196779, Z85996, AC005046, AL049869, U95743, AL133321, AF165926, AC004383, AC004466, AL133445, AL023807, AC005207, AC005821, AL021366, AC006316, AL022323, AC010205, AP000356, AF020503, Z98304, AC005520, AB026898, AC002556, AC005609, AP000510, AC005703, AC009178, AC007687, AC006026, AL117351, AL021579, AC002553, AC006065, AC007564, AC005874, AD001527, AC005962, AC005755, D87675, AC008040, AL049646, U91327, AC007066, AP000038, AL031133, AF067844, AL132777, AC005920, AL133448, AL008732, AC005152, AP000141, AC005323, AP0Q0501, AC004196, AL133246, AC002492, AC006552, AC006406, AC004167, AC007227, AL050348, AC005901, AC005562, AL008583, AC005094, AF001549, AC006965, AC004408, AC007199, U96629, AC007371, AL109801, AC005015, AC004126, AC005534, AC005409, AL031257, AC002429, AC009464, AC004232, AL021154, Z94056, AC004072, AL021918, AC005900, AB014078, AL034369, AP000088, AL050309, Z82206, AC007041, AF111167, AL031597, AC009516, AC002425, AC004253, AC009509, Z75887, AC007052, AL049760, AP000152, AP000010, AJ239322, AF027390, AL121603, AC000353, AB020868, AC006241, AL008710, AC002996, AL049776, AC008072, Z82244, AC003101, Z82217, AC004099, AC002470, AL031313, AL031664, AF134726, AL133163, and AC006597. HPFCP53 2145 526574 1-487 15-501 H66573, AA381762, AI689019, H54210, AA563770, AA664604, AI244254, AW021116, AI500552, AA130647, AA879053, AI275183, AA669706, H64777, AA367788, AA468486, AA604843, AI588856, N45421, AA573213, H93293, AA310557, AI004591, F02412, AI623563, AI270476, AW168483, T08421, AI309384, AA448838, AI803809, N67387, H55894, AA837715, AI471691, AA298386, AA599495, AI473701, AI279759, AA904275, AI627581, F02421, AI440324, AI598060, AI754291, R92640, AI471572, T03203, AA574286, AI357551, AI885572, AW189353, AA650447, AW168479, AI271762, AI305258, AI360514, AI609223, AL046746, AA669709, AI687962, N38789, AI076236, AA847099, AI821044, AA669102, AA487542, AA679872, AA491484, AA077776, F17700, AA086318, AI561116, AA378683, AA558344, M78007, AA365586, AW079809, AA613627, AI889579, W95503, T94116, H96518, AW270256, AW404844, H44786, AI915081, AA664283, AL045709, AA640979, AC012627, AC005969, AC002452, AC003664, AC005841, AJ250915, AC007999, M17262, AL049775, AC009509, AC004854, AC005620, AC005988, AC003086, AC002314, AD000671, AC004805, AL022313, Z84487, AC005207, AC004783, AL031665, AC003690, AL020997, AL096817, AC004263, AL022318, L48038, AL022578, AC002059, U63721, AL049793, AC004659, AL137434, AC004254, AL020996, AL021937, AC000003, AC005832, AL022156, AC006273, AC000026, AC002115, I34294, AC007435, AC005913, AC005291, AL049589, AL096791, AC003110, AC004637, AL021155, AC007363, AL109837, AC020663, AC006043, AC006126, AC006930, AB015355, AC000052, AC005072, AC018633, AL033392, AL031447, AC005277, AC007371, AC005274, U47924, AC006512, AC007386, U73167, U90094, AC005498, AC007228, AF092925, AC002544, AC004967, AF187725, AC005164, AC005548, Z98884, U29953, AC005921, Z85987, U62292, AC005911, AL023494, AC011504, AC008273, AC004890, AC006538, AC006487, AL031431, AC005746, AC005378, AC003989, AC007326, AC005908, U75285, Z49237, AC005512, AC003963, AC005377, AC005368, AC005154, AL034379, AL080250, AL031664, AL121767, AP000128, AP000206, AC007666, AC006501, AP000245, AP001053, AC009514, AC004019, AC002558, AJ239321, AD000092, AL022721, AC004033, AC005899, AC005932, AL031662, AL008725, AL049794, AC003663, AC005006, AP000553, AC009516, AC005874, AF134471, AC007055, AC002073, AL031602, AL022165, AC005089, AL049709, AC005358, AC006057, AC004552, AC004668, AC002994, AC005580, AC005390, AC005288, AL008635, AC006050, AC004859, AL035455, AC003982, AC005602, U07563, AL022320, AL035659, AF196779, AC008044, AC006014, Z82198, AC008115, AC005488, AC005581, AC005480, AC005588, U80017, AC010077, AC005722, AC005940, AL133353, AL035530, AC003101, Z46773, AC005482, AC005318, Z93241, AL031432, AL021707, AC004887, AC008179, AL133216, AC005484, AP000493, AC005529, AC005599, AF030294, AC004150, AL121653, AC005209, AC006511, AL109628, AL022396, AL049872, AP000688, Y10196, AF200923, U88317, AC005081, Z83856, AC005796, AC005387, AC006361, AC004016, Z95703, AC003958, AC005519, AP001067, AC005520, AC005231, AL078584, AC009802, AC000134, Z98048, AL031311, Z68756, AC005778, AF042484, AL078472, AC007690, AC005822, AC004253, AC004832, AL078634, AL031466, AB007872, AL096772, Z69917, AP001059, AC004678, AP001058, U07562, AL035398, AC004596, AC004891, AC004460, AC010197, AC007388, and AL133241. HPFCM45 2146 723501 1-537 15-551 H14121, AI375113, AA744592, AA960851, AI298360, AW293609, AW386311, AW386307, AW379359, and AW386340. HPFCM27 2147 682098 1-537 15-551 AI126345, N75862, and N22068. HPFCL56 2148 732601 1-343 15-357 AA424616, AW206710, W48815, and AA284281. HPFCL24 2149 867889 1-321 15-335 AI741779, AI203371, AA464709, AA725428, AA771747, U25770, and AA725175. HPFCG02 2150 921196 1-376 15-390 H66442, and AC005484. HPFCA01 2151 928672 1-412 15-426 T95327, AI823904, AW206324, T95680, AI369869, AI939557, and AC005531. HPELD12 2152 969248 1-671 15-685 AI801883, AA782908, AA026115, and AA770002. HPEKI04 2153 926104 1-413 15-427 T77896, T77813, and AA009652. HPEKE01 2154 914414 1-521 15-535 AA977210, AI589896, AI198170, and AI557234. HPEBT82 2155 524246 1-146 15-160 AL040143, AA747480, C06327, AA747276, AI888365, AA502103, AA132553, AW303196, AW301350, AA310158, AW274349, AL079433, AI865364, AA747375, AI537185, AI890348, AA828704, AI434706, AI536146, AI370475, AL042420, AI306028, AC004972, AL132987, AC006017, AC004812, AC007226, AL031721, AF196779, AC002553, AL034429, AC006057, AC006965, AP001051, AC006449, AC003043, AL031650, Z83849, AC007064, AL133245, AC006160, AC006277, AC004884, AC002558, AL031602, AL132992, AL035361, AC005233, AP000556, Z98200, AC007052, AC002429, AC007546, AC018633, AC005844, L44140, AL050341, U66059, AC005250, AC002492, Z99716, AC004585, AC004028, AL021939, Z83840, AC007878, AL049757, AC005562, AL031848, AC005695, AC005324, AC007773, AC003957, AC005548, AL049776, AC008039, AC006548, AC003037, AC002485, AC005321, AC005231, AC005771, AF111167, AL049872, AP000111, AL035460, AP000961, AL133297, AL031662, AC009247, AC016025, AC005412, AC002301, AC002041, AC000081, AC007536, AL023803, AC004861, AP000557, AC009516, AC004466, AC005358, AC008045, AL008718, AL031280, Y14768, AF117829, AC007686, AC004149, AC004217, AC005971, AC003007, AB003151, AC004647, AC004150, AP000505, Z86090, AC008372, AC006362, AC002316, AC005759, AJ003147, AC002404, AC005566, AC004890, AP000501, AL133289, AC010077, AC007040, AL022329, AL022397, AF196969, AC006039, AL121603, AL023577, Z82244, Z97196, AC005632, AC005808, AC007421, AC006285, AP000344, AC009479, AC005037, AC007537, AC000353, AC005089, AL031123, AC004460, AC004913, AC004019, AP000018, AC000003, AL133163, Z95115, AC006486, and AC007227. HPEBT78 2156 773844 1-136 15-150 AW339853,AW188119,AI991660,AI369596,AI494519, andN39086. HPEBT68 2157 753692 1-233 15-247 T40308, AA584201, AI732378, AI872020, AW327868, AA679936, AL042853, AA847952, AA828749, AA581903, AI270559, AA478355, AL119691, AA515549, AI580250, AI963720, AW265385, AA531186, AW274349, AW002350, AA580808, AI457397, AA618452, AA503600, AI284640, AI696962, AA640410, AA640430, AI908730, AA847499, AA015846, AA682912, AI783581, AI345518, AA806796, AI754955, AW131208, AI583283, AL046409, AI358571, AL121336, AA610688, AI369580, AI732120, AW303196, AA658362, AW022406, AW264934, AA503475, AW419262, AW088846, AA631480, AI677645, AI589230, AL043719, AA623002, AI632991, AL046457, AA680243, AW301350, AA613203, AI521062, AW075511, AI350211, AA720702, AI568678, AL036037, AA483256, AL121235, AA812281, AA532700, AA491284, AA846952, AA724333, AA533303, AI431303, AI471887, AA493708, AF034184, AI570261, AW023149, AI754253, AW157608, AI745325, AA358409, AL041146, AA491814, AA503258, AI687343, AA490183, AW151713, AI298710, AA503039, AI281881, M37551, U57007, AC006039, AC006207, AC004834, AC006285, U73634, AC005531, AP000567, AL020997, AC004797, AC006539, AC007226, Z68756, AC006037, AC005598, AL121655, AL031281, AC007050, AC005081, AC005913, AC006238, AL049766, AC016025, AC007216, AC004848, AC005191, AL080243, AF161800, AC004990, AL021368, AC000353, AC007685, X75335, D83989, L49046, Z86090, AL021978, AC005754, AC005180, AF002223, AC006538, AL132992, AP000009, AC007845, AL117258, AL078621, U57004, AC005701, AL021878, AC006057, AC007160, AL023494, AB004907, U91322, AC004678, AL009028, AC004002, AC015853, AC005666, AC007370, AC004150, AC002504, AF165926, AF038458, AC004895, AL033392, AC005863, AC006449, AC005274, AC005520, AC004596, AL049759, AL022326, AB023049, AC003109, AL133163, AL022320, AF002992, U07000, AC008079, AL096808, AP000225, AL022311, AC012599, AL031722, AC008080, Z84721, AC007731, AC002465, AC005102, AC007043, AC005379, AC005500, AC000024, AL049633, AP000354, AL031255, AC004236, AL133245, AC006075, AC004556, AC006160, U57008, AL021877, AF217403, AC004021, AC007999, AL135744, AC005363, AP000556, AC007270, AL022302, AR036572, U91328, AL132712, AC004019, AL078603, AC005255, AC005037, AC005067, AC004913, AC005242, AL031657, AC005258, AL049539, AC005632, AC004643, AC002301, U82696, AJ246003, AP000150, AC005566, AC006011, AC004638, U95742, AC016026, AC004671, Z82190, AC006023, AC006270, AL080238, AC003075, AC007064, AC006597, AC006540, Z98050, Z95152, AC005071, D87008, AL109628, AC007537, AC004859, X69907, AC004944, AL049743, AC004485, AL035423, AC005091, AL034430, AC009247, AF015148, AC005015, AC006958, AP000344, Z98044, AL049696, AL132777, AP000356, AF045555, AC006474, AC004254, AL023876, AF015153, Z79997, AF042090, AL121658, AC010436, AC007751, AC005920, X55926, AP000114, AP000046, D83253, AC006042, AL133289, X54180, U18391, Z99754, U18392, U57006, U18394, U18395, X55925, U57005, X54179, AP000359, AL023879, AC006241, D88268, AC006453, X55929, AC003070, AC007066, X55933, AC005088, AC004854, AC003104, AC004802, AP000303, AP000557, AC005516, AC005399, AC009405, AC002395, AL049825, AL022724, AL133382, AL031228, AL035681, AL022328, AC005013, AC005600, AC002412, AC006327, Z95331, AC005212, Z98744, AC008041, AC004051, AC002067, AL035072, Z99716, AL109759, AP000563, AC007546, AL022322, AL034549, U67825, AL078611, AC004463, AL031587, and Z93930. HPEBT54 2158 731002 1-385 15-399 HPEBT49 2159 530021 1-372 15-386 AC005089, AC005940, U91323, AC005666, AC007546, and AC003093. HPEBT34 2160 706836 1-358 15-372 HPEBT14 2161 535061 1-235 15-249 AW179046, AL133500, and AC003071. HPEBT07 2162 954214 1-303 15-317 AC002351, AC005875, AL022326, and AC006312. HPEBO67 2163 578516 1-216 15-230 H78283, AI127890, AW090182, AW001838, W72897, and AF086351. HPEBL08 2164 960240 1-408 15-422 AI021894, AI359246, AI422145, AI800895, AI689642, T89411, and AC007684. HPEBH01 2165 921767 1-333 15-347 AA019103. HPEBG89 2166 785942 1-505 15-519 AA425851, and AA425691. HPEBG10 2167 867888 1-271 15-285 AA533740, and AI984425. HPEBA89 2168 910250 1-490 15-504 AA758474. HPEBA61 2169 742251 1-74 15-88 AC007036. HPEBA05 2170 928027 1-357 15-371 AI217338. HPEAG43 2171 468542 1-485 15-499 AA634147, AA837087, N63746, AC006197, AL031311, AC006079, AL035555, AC004790, AL031670, AL022727, AC002457, AL096803, AL049874, Z98048, AC005881, AC003663, and AE000659. HPEAD72 2172 761472 1-371 15-385 H24817. HPEAB12 2173 968847 1-498 15-512 AI656658, AI991597, AI962317, AW204277, and AI963904. HPEAA57 2174 514231 1-441 15-455 AC008039. HPEAA40 2175 867899 1-332 15-346 AA879011. HPDWR11 2176 965249 1-629 15-643 AI694423, AA773635, AA443144, AA443143, AI918138, AW206226, AI337165, AI350411, N80841, W07349, AW197541, and AW138024. HPDWN05 2177 928563 1-478 15-492 AI627858, AI674644, AI521975, AA653609, AA447670, R37708, H18650, and P34959. HPDVM01 2178 913859 1-454 15-468 AA905449, AA969031, U62317, and AC005859. HPDVD11 2179 965276 1-293 15-307 AI809869, and AA918215. HPDRU11 2180 965307 1-346 15-360 N52071. HPDRR06 2181 968601 1-436 15-450 AA8061 14, AW242125, AI249498, AI560615, AI274667, AI972210, Z28533, and AW361342. HPDRN07 2182 951838 1-601 15-615 AI365618, AA197089, AW023975, AI570067, AW008217, H05066, AI828721, AI620666, H24331, AI684999, AA205931, AA601336, AI572680, AI921744, AI890297, AW338376, AI619994, AA171400, AI281622, AI174489, AA218684, AA878350, AA523812, AA579082, AI821342, AA935827, AW337817, AI860423, AW020102, AW021674, AW275432, AI889177, AA084320, AI798521, AA847341, AA507499, AA112864, AI434103, AA610644, AA557945, AA584241, AI819419, AI249365, H79277, AI000314, AA720582, AA493245, AA227713, AW157128, AA636077, AI254267, AI567676, AI538404, AI862716, AA135761, AI733523, AW021917, AA584489, AI969090, AI872229, AI813920, AW129188, AA629668, AL044966, AI038029, R64110, AI755214, AI754567, AI925588, R79396, AI114755, AA669238, AI734076, AA809546, AA733089, N99245, AI174827, W44797, AI857834, H47461, AI609992, N27340, AA618531, AA814719, AW149241, AW340905, AA826109, AA779599, AA598608, AA554289, AW028376, AA550989, AI148840, AW192930, AW069769, AI754105, C75332, AI439525, AI307563, AI049845, AA280886, AL135490, AA112646, AW023111, AI201983, AA225141, AW277240, AW439224, AI123488, AW021847, N49298, AA525156, AW085626, AW162762, AA570255, AA834891, W69639, AA522864, AI803824, AA129000, AI003391, AA364147, AI282479, AI754926, AA573564, AL044701, AW189853, AA657808, AA182928, H54601, AA167656, M77888, T50676, F35684, AA702637, AA969564, W02419, AA342029, AW237905, AI791659, R61387, AA086042, AI732690, AI890857, AI732327, AA635150, AI815210, AI926876, N66744, AI459879, AI370470, AW083966, AI754257, AI932871, AA492496, R67038, AI587213, AA488419, AA714011, H59856, AI734075, AA772493, AA904211, AA633804, AW243817, AW070901, AI934664, AW419227, AA862312, AI446574, AI249688, AI921765, AW085811, AA100107, F23221, AA503298, AA640305, AI523356, AA470490, AA828840, AA653291, AA483606, AI537020, AC004263, AC006947, AP000359, AC005327, Z83844, AC007686, AC007055, AC006530, AC005015, AL049553, AF207955, AC006441, AL049780, AC004228, AC007540, AL035417, Y10196, AC001228, AP000510, AC005043, AL049709, AL034423, AC007030, AF195658, AC005081, Z97196, AL139054, AC007066, AC005519, Z99716, AL031587, AL136295, AC007308, AC006039, AC005529, AC007695, AL133246, AL020998, AC005412, AF111169, Z98044, AL049569, AC004999, AC005702, AC006241, AC004882, AL031291, AL031651, AL121657, AL021937, AC006312, AC004938, Z85987, AC004707, AC005180, Z82184, AL022165, AC004150, AC002352, AC004770, AC002470, AC004963, Z93241, AC004851, Z70289, AL031055, AC002310, AC005668, AC010200, AL035588, AC004974, AC004841, AL049776, AC006449, AC005280, U91321, AF001549, AC004477, AC002115, U91318, AL022312, Z99774, AC003025, AL034548, AC004973, AC005684, AC007227, Z93017, AC007151, AC004811, U91326, AC004605, AC005031, AC012384, AL031985, AF095725, AC000065, AF139813, AC006055, AL022314, AL031005, AC007207, U80017, Z98051, AL022330, AC005815, AC005005, AF207550, AC002347, AC004787, AL031284, AL035458, AC000025, AC006561, AC002544, AL022097, AC004797, AF196779, AC005377, AL117694, AL009181, AL121754, AL096712, M89651, AC005932, Z48051, AF047825, AC005838, AC007773, AC004032, AC005874, AF134471, Z98949, AP000501, AC005320, AL031664, AL035071, AB023049, Y18000, AC004832, AC007955, AC007917, AB023060, AC006581, U95739, AL035089, AC004169, AL031667, AC004825, AC004531, Z95115, AL034420, AC006511, AL031295, AC006560, AL031053, AF111167, AC005696, AC005220, AC005375, AC002059, AC006057, AL035422, AC003101, AL080312, AL109839, AC007225, AL049829, AL109984, AC004820, AP000558, AC005520, AL080243, AL008718, AC003104, AC004686, AL109627, AL133546, AL031666, Z95118, AL049872, AL050318, AC006162, AJ251973, U78027, AC004230, AC004887, AC002400, AC007011, AC006229, AC006450, AC004883, AC002375, AC004000, AF196971, AC005871, AE000658, AC002316, AC002369, Z97055, AC007016, AC006942, AP000555, AC004417, AL035461, AC004216, AL135960, AJ131016, AC007041, AL034554, AC003043, AC009516, AL121653, AL035681, AC005058, AL030996, Z82215, AC005261, AL031281, AB026898, AC005908, AC007546, AP000114, AP000046, AL022326, AL021939, AL133445, AD000092, Z85996, AL033524, AC003006, AC000105, AC005539, AL020997, AC003969, AL078621, AC010209, AC006236, AL078581, AC005562, AC008372, AC005899, AL096701, AC004834, AC004687, AL035086, AC004638, AC004881, AP000036, and AL133355. HPDRG01 2183 914416 1-757 15-771 AW182845, R06052, AI342212, R05947, and Z61625. HPDPS12 2184 969342 1-448 15-462 AA703816, AA258655, and AW173253. HPDPP12 2185 969341 1-466 15-480 AA491958. HPDPC08 2186 957822 1-443 15-457 AL043010. HPDOW10 2187 961782 1-430 15-444 AI301598, AA889756, AA279491, AI301605, AA721450, and AL020997. HPDOO10 2188 961881 1-754 15-768 AI939627, AI199438, AI498865, Z99396, AW392670, AL036418, AL038837, AL037051, AL036725, AW384394, AL036858, AA631969, AW372827, AL119443, AW363220, AL119497, AL119483, AL039074, AL119319, AL119355, AL119457, AL119324, AL036924, U46349, AL119484, AL119363, AL119391, U46350, AL119522, U46341, U46351, AL119341, AL038509, AL119418, AL119335, AL039564, AL119396, AL039085, AL039156, AL039108, AL039109, AL039128, AL119496, U46347, AL037639, AL119444, AL134531, AL037094, AL039659, AL036196, AL036190, AL037205, AI142137, AL119439, U46346, AL042984, AL037526, AL134538, AL037085, AL038531, AL042614, AL036767, AL043029, AL037082, AL037077, AL036268, AL119399, AL042965, AL042975, AL134527, U46345, AL039625, AL039648, AL045337, AL038520, AL119488, AL042542, AL036238, AL038851, AL043019, AL042551, AL043033, AL038447, AL043011, AL042544, AL039678, AL039629, AL042450, AL039386, AL037615, AL043003, AL119464, AL036733, AL037027, AL037178, AL036774, AL036719, AL036998, AL039410, AL036679, AL036886, AL036765, AL036191, AL036158, AR060234, AR066494, A81671, AR023813, AR064707, AR069079, AB026436, and AR054110. HPDOF11 2189 965491 1-870 15-884 AI939537, AI363373, and AL021997. HPCTK02 2190 917480 1-434 15-448 N24908, AI916992, and N49979. HPCTD03 2191 922149 1-361 15-375 AF150341, AI767747, AI972527, N85789, AI637774, AC001555, L81893, AC006077, and L81892. HPCTC04 2192 925777 1-485 15-499 AI635931, AW241388, AI360647, AI218091, AI868064, AI824561, AC006198, and AL079338. HPCQQ07 2193 951646 1-399 15-413 AI350228, AI792022, R20916, AI701465, AI457852, AI261722, AI741246, AF017104, and AC016831. HPCPM63 2194 954940 1-483 15-497 AI131455, and AI761541. HPCOV68 2195 911075 1-578 15-592 AA604716, R49364, and AC004500. HPCAO89 2196 946913 1-464 15-478 HPCAK66 2197 320415 1-331 15-345 HPCAG81 2198 778177 1-388 15-402 R33353, AA482623, and AW237518. HPCAF65 2199 573368 1-410 15-424 AW023975, AA610255, AA847622, AI223968, AA599080, AA132912, AA358086, AA736713, AI066711, H71678, AA744094, AA744048, AA551268, AA282951, AW151761, AA557945, AI537020, AL045476, AA515728, AI828721, AI025930, AI925065, AI823705, H12857, AW245354, AA856866, AI824476, W02497, AI446259, AI590404, AW104163, AW440368, N41775, AA984829, AA779783, AA847047, H40324, AA719523, AI078409, AI973173, AW088631, AA993636, AI636734, N90460, AI816537, AW129188, AA664604, AI471467, AI421755, T07327, AI282479, AI307563, AA747375, AC005484, AC002310, AC007376, AC006966, AC005913, AC002303, AL121769, AL031427, AF045555, AC006125, AC004522, AC006130, AL031657, AC005081, AL079295, AL049829, AF207550, AL031846, AC002418, AC004859, AC007371, AF196779, AL031431, AC004662, AC004386, AC004882, AC005225, AC002504, Z83844, AC005529, AL121653, Z97056, AC005695, AC004491, AC004813, Z98884, AC005972, Z68870, L44140, AC003108, Z98200, Z85987, AC005520, U82668, AL035658, AC001234, AC006449, AC005598, AL034400, AL031228, AL035684, AC007842, AL136295, AC004686, D86995, AC007227, AC007327, AC003010, AC000353, AC000025, AC005046, AC004834, AL132777, D87675, AC002302, AC002551, AC002128, AL109963, AL022476, AC007129, U91321, AL031276, Z98048, AC009501, AL135960, AJ131016, AC009542, AL008629, AF109907, AC004895, AC004477, AC002492, AL121603, AC005412, AL132987, AF134726, AC004876, AC005546, AC007664, AC007541, AP000011, AP000152, AC006088, AL049694, AC007766, AC004881, AC007358, AC002126, AC007216, AL031311, AC004134, AC005940, AC005971, AC005089, AC004099, AC003101, AC005277, AC007308, AC007551, AL049872, U78027, AL031283, AL078593, AC002470, AL022322, AC006064, AF011889, AC007565, AL135744, AL109613, AC005696, AC005383, AC007536, AL031230, AC005730, AL008735, AC004975, AL133448, AC009330, AC004851, AC007681, AC005821, AL034429, AC005736, AC004821, AC002425, AC003682, AC005666, AC007226, AC000134, U52112, AC002400, AC007193, AC008044, AC007283, AC006057, AC005531, AL031005, AF031075, AC004144, AC005015, AC006285, AL049757, AL022396, Z83843, AL096791, AL033527, AL022721, AP000048, AC006333, AL022165, AC006487, AL031287, AC004792, U62293, AC007263, U63721, Z83822, AC007999, AF017104, AC008015, U96629, AL024509, AC007298, AF111167, AC005519, AC002059, AP000115, AP000212, AP000134, AC006552, AC005537, AC004382, AF030876, AC005562, AC004596, AC005280, AC007546, AC002350, AL078611, AC006026, Z96776, AF030453, AC006241, AC016830, AL078476, AL021154, Z95115, AC004832, AL049539, AC004655, AL109623, AP000553, AC006006, AC006530, AC003043, AC007160, AL049748, AC005363, AC005527, AC006505, U10087, AC005071, AL078581, AL109758, AC006146, AC005486, AC016025, A3009610, Z82180, AL035422, AC005082, AR036572, U91328, U91323, AL109627, AC005839, AL080250, AC005261 AL133382, AC009181, AC000082, AP001060, AP000010, and AC002347. HPCAD17 2200 584754 1-1073 15-1087 HPCAB54 2201 728857 1-395 15-409 AA112321. HPCAB45 2202 575233 1-233 15-247 HOVEV01 2203 914553 1-721 15-735 AI042120, AI520690, AI346542, R80717, N70361, H97746, AA678405, T48628, T95511, R50705, AI678296, R99146, AA973947, AW392739, AL046192, W05002, AW138135, R50704, AW371372, AI620712, AI350513, AI423566, AI342100, R80716, D79458, AA933894, T95510, AA622588, T48627, AW392719, AA781834, AA258040, AL040243, AI684279, AI537677, AW104724, AI624279, AI564719, AL119748, AI815232, D79367, AI567940, AI254731, AW132056, AI445025, AI648509, AI491852, AL045266, AI537024, AL049085, AI500706, AI922901, AI499463, AW262565, AI269862, AI275175, AI802542, AI677796, AI433976, AL045500, AI433157, AL043326, AI500523, AI539771, AL134830, AI619502, AI335449, AI500659, AI491776, AI648663, AI520785, AI536638, AI702068, AI801766, AI269205, AI811344, AW087445, AI637584, AI284484, AI559296, AI591316, AI554427, AI890833, AI926790, AW026882, AW148408, AW071349, AW301409, AI445237, AW151138, AL079977, AI610402, AW198090, AI921248, AI702073, AW004685, AI573032, AI446628, AW087207, AI682971, AW088793, AI868831, AI624206, AI702406, AI571909, AI475451, AW162071, AI287489, AW150578, AI654276, AI889376, AI620284, AI524671, AW129659, AL079963, AW169671, AI560099, AI468872, AL036361, AI440239, AI815855, AW090013, AI249257, AI590999, AI866608, AI568296, AI538716, AI432969, AI439745, AA225339, AI349004, AI872711, AI828731, AI569583, AI499393, AI871697, AI273048, AW268220, AI520862, AL047763, AI828682, AI250293, AI590227, AL043981, AI696612, AI824746, AW274192, AI572676, AI583065, AI584140, AL041150, AI536685, AI436456, AW020561, AI538259, AI570909, AI499131, AW082113, AA835801, AI567846, AI567993, AI432656, AI475371, AL121328, AI431975, AW403717, AW073270, AW168795, AI857296, AI701074, AI612913, AI625079, AW148363, AI627360, AL042551, AI540832, AI863014, AW149869, AI567128, AI635461, AI274508, AI499512, AW080327, AI889133, AI445432, AW075667, AI284517, AI434223, AI859511, AI590118, AI538829, AI654750, AW167924, AI538218, AI687362, AW148716, AI862144, AL119791, AW082040, AL042628, AI679990, AI913437, AL121270, AI886124, AI687728, AI590021, AW301505, AI224992, AI349598, AW170635, AI784252, AI697137, AI682841, AI610756, AI521012, AI801608, AI819326, AI590120, AI499285, AI521040, AI679321, AW086113, AW118398, AW103371, AW008048, AL042745, AI274013, AL036736, AI633419, AW166903, AI064830, AI862139, AI801322, AI539780, AI690426, AI630928, AI289937, AW169653, AI610645, AI801325, AI636445, AI634345, AI518683, AI609580, AI364788, AI500146, AI280637, AI884469, AI434281, AI569616, AC007860, I48979, I89947, I48978, S68736, AL050149, AF090901, AL110196, AL133080, A08916, AL117460, AL110221, AF113019, Y11254, I89931, AL122050, A08913, AF118070, AF090934, AF078844, AF113676, AL050138, AL122123, E07361, X84990, AF113677, AF158248, X82434, AL137557, AJ000937, AL133640, AF111851, AL050116, X63574, AL122121, AF106862, Y16645, AF118094, 878214, AF017152, AL049314, AL137283, A65341, AL080124, AL133075, AF104032, E03348, AF113689, AF113694, Y11587, AL133016, AB019565, AF090900, AL049452, AL080060, AL122093, U42766, AL050277, AR059958, AF090903, AF125949, AF090943, AL137459, AL117457, AL050108, AF090896, AL137527, A93016, AF113691, AF113699, I49625, AL133557, AL096744, AL050393, AF079765, AF146568, AL133565, AF113690, AL049938, AF113013, AJ242859, L31396, AF091084, L31397, AF125948, AF017437, AF118064, AL133093, AL080137, AL050146, AL117394, AL133606, AL110225, AL049466, AL049382, AL049430, AC002086, U91329, AF097996, E02349, AJ238278, AL137550, AR011880, A08910, AL133560, AL117585, A58524, A58523, AL049464, AE177401, AL122098, E07108, AL122049, AL049300, Z82022, AL034402, AL117583, AF067728, A08912, AF183393, U00763, U35846, A77033, A77035, I03321, AL117435, A08909, AL050024, AL137271, X72889, AL137463, I33392, AL133113, X70685, AL022165, AL133568, AL137648, X65873, AL122110, AL049283, AL137560, AL137538, A03736, U72620, X96540, X93495, AI2297, AL080159, U80742, X98834, I09360, AL080127, AJ012755, AF087943, U67958, AL133072, AL110197, AF061943, E08263, E08264, AF000145, AF153205, AL137523, S61953, AC006336, AL133104, AL050172, X53587, I42402, AL137521, Y09972, AL133014, AF111112, AL122111, AC002464, AC005940, E15569, AL133077, AF119337, A93350, I26207, I66342, AF026816, AL137526, I17767, AC008394, AF026124, AC006371, AF079763, AL137556, AF095901, AC004383, U68387, A08911, Z37987, Y14314, I00734, E00617, E00717, E00778, AR000496, U39656, AF185576, AL122118, AR054984, AR038969, M30514, AL137476, AL133067, and AF057300. HOVEU10 2204 961865 1-595 15-609 Z99396, AW392670, U46351, AL042450, AL043019, AL043033, U46341, U46350, AL119324, AL043008, AL119457, AL119335, AL042989, AL119401, AL134536, U46347, AL043029, AL134525, AL042614, AL043003, AL134531, and AR066494. HOVEU06 2205 933737 1-324 15-338 HOVEO04 2206 926209 1-165 15-179 W24148. HOVEE20 2207 909030 1-432 15-446 N77523, AW371758, AA295628, AF150239, AA351493, and AF161544. HOVDD82 2208 948619 1-514 15-528 AA814916, Z99396, AL036858, AL119319, AW392670, AL036924, AL036418, AL038837, AA631969, AL119443, AL037051, AL036725, AL037094, AW372827, AW384394, AL119497, AW363220, U46349, U46351, U46341, AL119341, AL037085, AL119483, AL039074, AL037639, AL119335, U46350, AL036196, AL037082, AL119457, AL119324, AL037077, U46345, AL119484, AL119363, AL119391, AL119355, U46346, AL134920, AL119522, AL119396, AL119418, AL042975, U46347, AL038509, AL119444, AL119496, AL039564, AL039085, AL039156, AL134533, AL042965, AL039108, AL039109, AL039128, AL042433, AL042614, AL119464, AL119439, AL119399, AL134902, AL042984, AL037615, AL036268, AL134531, AI142131, AL036190, AL037526, AL134538, AL042551, AL036733, AL038520, AL043019, AL042970, AL038531, AL134529, AL042450, AL036767, AL043029, AL042544, AL042542, AL119488, AL036238, AL038851, AL043003, AL036998, AL037178, AL037027, AL036679, AL036191, AR060234, AR066494, A81671, AR023813, AR064707, AR069079, AB026436, and AR054110. HOVDD10 2209 961887 1-391 15-405 N43177. HOVCP77 2210 772210 1-604 15-618 R41728, H24352, R39867, R60774, F10382, R59965, R45695, Z38252, R42431, D81791, R45265, and F01387. HOVCO50 2211 932544 1-572 15-586 AW235624, AI703030, W56086, AA442067, AA460968, AA478475, AA830981, AA767533, and AI193242. HOVCN57 2212 734779 1-455 15-469 H44610. HOVCM77 2213 772208 1-429 15-443 R61245, AP000495, and AC002076. HOVCM03 2214 924196 1-304 15-318 AI193258. HOVCI89 2215 786917 1-321 15-335 AA436552, AI280208, AA885577, AI692637, AI435485, and Z99289. HOVCI08 2216 959470 1-1020 15-1034 AA634064, AW082209, AA781620, R50614, R53385, AI991409, AA035741, H39673, Z59735, Z54887, Z54886, and Z65048. HOVCD33 2217 702445 1-315 15-329 R44210, and AL040454. HOVCC57 2218 465313 1-393 15-407 AI347543, AI004448, and T40955. HOVBQ07 2219 858863 1-591 15-605 AA552163, AA469920, AW205550, AW341591, AI742174, AI620502, AW027003, W91950, AW026996, W91877, AI215036, AI207964, and AA523613. HOVBK69 2220 757594 1-411 15-425 AA436185, AW052178, H96098, AA653580, and AA416482. HOVBK38 2221 956238 1-663 15-677 AI140254, AA948324, AA251283, AA862605, AI240375, AA825275, AA999858, AI301152, AI342674, AA011200, AA815310, W58239, AA931576, AI094483, AI302269, AI202732, AA649941, AI342676, R71253, AA449275, AI383771, AI831916, AI308112, R12392, AA525847, H52934, H06918, R34144, W58328, AI695242, R71305, AA876287, W89053, N93696, AA005209, AA251692, R34143, W89107, and AC006251. HOVBK24 2222 858857 1-395 15-409 T96953, and T72381. HOVBI67 2223 751665 1-861 15-875 AI040113, W87283, AA700434, W87282, and AC004975. HOVBI20 2224 669730 1-215 15-229 H80446. HOVAZ89 2225 904818 1-483 15-497 HOVAZ65 2226 750273 1-445 15-459 AA406496, N46132, AA406518, and H96338. HOVAY88 2227 827077 1-397 15-411 HOVAY55 2228 736077 1-472 15-486 H01079. HOVAY42 2229 713812 1-373 15-387 HOVAY03 2230 921959 1-276 15-290 AL139054. HOVAW62 2231 745704 1-234 15-248 AA062554, AI869336, AW170609, H13995, AA631622, H13997, H14028, AI569586, AA632137, and AC004143. HOVA025 2232 678163 1-361 15-375 H57248. HOVAN51 2233 725005 1-535 15-549 T79639, N70408, N57728, T83855, AA001363, AI078086, T93794, and W03748. HOVAJ07 2234 953422 1-438 15-452 H26739, AI668579, AI733528, and AL020995. HOVAJ05 2235 932093 1-453 15-467 AI031837, AI985078, T25928, AC003692, AL121973, AC004019, AL049766, and AL121603. HOVAF07 2236 953553 1-151 15-165 AA828882, and AA829114. HOVAF01 2237 916770 1-413 15-427 AI252937, N74027, AA836182, AW338228, AI744524, AA910108, AA772555, AI027046, AI823533, F02523, AI823535, AW102980, AA745302, AI371165, AW002825, AA887470, AF001549, AP000502, AC004651, AC002996, U91318, AF134726, AF053356, AC000353, AL023575, AC004820, AP000113, AP000045, AC004985, AL031587, AC002073, AC005288, AC005821, AC002310, AC004967, AC005071, Z93930, AP000553, AC007041, AC004703, AC006014, AC004552, AL023801, AC005015, AL035249, AC005081, AC007371, AC007216, AP000299, AL136295, AL031230, AL034549, AC003689, AL109628, AC004834, AC007358, Z98941, AC005620, AC007955, AC007382, AC007191, AC005765, AC006241, AL020997, AL031283, U91326, AL031659, AC005789, AC002544, AC005837, AL122023, AC005874, AF134471, AC004814, AC003047, AC005823, AC005086, AC004883, AL049843, AL009181, AL022323, AL008715, Z98200, AC012330, S79836, U11297, AL049832, AL096791, AL033547, AC002477, AC004125, AL050317, AC004882, AL031846, AC002357, AC002549, Z94801, AC007325, AL035405, AC007981, L47234, AC005911, AC000075, U80017, AC007151, AC002400, AC008079, U78027, AC004531, AC004983, AC004217, AJ003147, AF045555, AC004837, AC004257, AC006101, AC004953, AC004966, AC005363, AL050325, AC005606, AC006088, AC020663, AC007688, Z81364, AL024507, AC004832, U95742, AL022476, Z92542, AC004583, AF039907, AP000208, AC006544, AC005225, AP000247, AC007229, AL109627, AC008132, AF030453, Z99943, AC002553, Z97183, and AL049748. HOVAC77 2238 578783 1-353 15-367 HOVAC54 2239 578809 1-499 15-513 R06198. HOVAC26 2240 578810 1-410 15-424 AA180856, AA312397, AA477002, N64587, F03493, AA722297, AA550850, AI141130, AW246295, X56997, AC005253, AL133448, AC002477, AC003663, AJ003147, AC007308, AC006064, AL022320, AC007421, AL022323, AC005632, AC006480, AP000704, Z83840, AC005786, AL049779, Z85986, AC005520, AC005004, AL132712, Z98036, AC005274, AC007637, AC005089, AB023049, AC005231, AL049776, AC005180, AL133353, AC007676, AC009516, AC007298, AC006285, AC005940, AC005081, AL031295, AP000356, AC006211, AL021707, U63721, AC006101, AC004883, AC005048, AC020663, AC000134, AC012627, AC005488, AC007546, AP000065, AL080243, AC006511, AC002470, AL078638, AP000049, AC005332, U85195, AC004019, AP000311, AC005531, AC004491, AE000658, AL135744, AC005412, AL023553, AL008582, AP000557, AC005391, AL139054, AC002365, AC006538, AP000116, AP000555, AC006014, AL031733, AC007226, AF003529, AL031589, AC006449, U82668, AF134726, AC005971, AC004890, AC005841, AP000509, AL022721, AP000343, AC003977, AP000248, Z98950, AL079342, AL050318, AL049569, AC005005, AC004253, AC005243, AC005899, AP000556, AL031848, AC002347, AC004000, AC005229, AL133445, AC005184, AC006026, AC005029, AL132777, AC007227, AC016025, AC005519, AC003962, AL109627, AC004139, AL035398, AL031432, AL078581, D87675, AL020993, AC003029, AP000212, AP000134, and AL031282. HOVAB85 2241 578788 1-394 15-408 AA938198, AI480041, and AA836516. HOVAB61 2242 578791 1-672 15-686 AI912696, AA189100, AA449441, AI298393, N66646, AI281387, N66606, AA448930, T40424, T41267, N22111, AL096827, and AF086039. HOOKF10 2243 961499 1-479 15-493 AI292005. HOOKF04 2244 925784 1-577 15-591 AI807982, AI240099, AA868661, AA625993, AW269043, AI221135, AI024201, N33757, AI799092, and AF092091. HOOJU04 2245 925774 1-345 15-359 AI432402, AI276478, AI675712, and AA662663. HOOIN04 2246 925783 1-541 15-555 AI206132, AI760658, AW207202, AI361331, AI309566, AL119748, AI436462, AL049085, F37471, AL042628, AL040243, AL035684, AB014511, AF152243, AL122049, and AC000403. HOOJK11 2247 965292 1-472 15-486 AI333634, and H78014, HOOJH05 2248 928627 1-238 15-252 AI223084, AA411815, and AA403084. HOOJE02 2249 917454 1-372 15-386 AI192015. HOOJL05 2250 928644 1-430 15-444 AA470830, AI859849, AI766193, AW439625, AW439820, AI962973, AA464728, AI888957, AA463944, AA235454, AI933818, AA468183, AA844370, and AI127133. HOOIG03 2251 922510 1-423 15-437 AA088667. HOOHP02 2252 917424 1-415 15-429 AW024908, AA678379, AA477631, N54347, and R26531. HOOHE67 2253 969061 1-795 15-809 N95228, AW016802, AI375092, AI985579, AI188610, AI656562, AI972873, AI991588, AW055145, AI936408, AI292190, AI094172, AW182193, AI191047, AI078514, AI763004, AI830734, R38989, R49050, AA046092, H49273, AI202609, R99234, AI262420, H19327, AL037112, W87481, AA581541, N94137, AI221613, AA404487, W69271, AI521710, Z38912, R05523, H12506, AI468774, AA046135, AI984653, AW236116, AA099158, AA019723, AI554117, AI090954, AW007126, N70968, AL035700, AC007270, and AF131754. HOOHD06 2254 933873 1-235 15-249 AI560165, AI955723, AW138740, and AL133011. HOOAB23 2255 522227 1-542 15-556 AW292981, AA363225, AA363226, AI250281, AI912329, AI745457, AI815151, AI744548, AI760693, AA076391, H74235, AA491864, AA557604, AW301854, AA601230, AL079769, W60522, AI370264, AA501906, H63742, AC005544, AC005921, AF053356, AC016025, AC006285, AC005702, AB023048, AF165926, AC005280, AL035089, AC007262, AC004000, AL031848, AC005529, AC004150, AL132777, AL049874, AC005844, AC006354, AL031733, AC005212, AL009151, AC005071, Z95113, AC007540, AL109865, AC007993, AC005520, AC004099, AF109907, AC002470, AF030453, AC000085, AC006958, D84394, AC005881, AL033527, AL133163, AL021154, AF152364, AL109839, AF118808, AC005261, AC005015, AL135744, AC009516, AC004797, AC002350, Z95152, AC005004, AC004686, AC005200, Z92542, AL031666, AF196779, AC002117, AL133448, AC005193, AC004253, AP000512, Z85986, AC004858, AC006344, AC005081, U82828, AL022336, AC004458, AC004963, AC006203, AC005726, AC002544, AC004841, AL022328, AP000553, AC005191, AL049694, AC004491, AC007055, AC003070, AC007207, AC006547, AC004531, AC016027, AP000689, AC006160, AC016830, AL022316, AC005288, AC005067, AC004659, L78833, AC005488, AL049758, AF088219, AC003982, AC006111, AP000555, AC006057, AC005694, AL049539, AC005065, AC000025, AL050307, AL022238, AF190465, AL034379, AC004970, AP000155, AP000013, AC004675, AB001523, Z83840, Z98941, AF067844, AL020993, Z82215, AC010209, AF200465, Z83843, AC007011, AC006101, and AC004024. HOOAB05 2256 932925 1-569 15-583 AI080164, and AA363261. HONAK10 2257 968610 1-324 15-338 AA362963, AA281759, AW117976, AL135744, AF196969, AC006539, AC006077, AL049850, AC009516, AC004678, AP000553, AC005372, AC005411, AL049780, AP000114, and AP000046. HONAH06 2258 936029 1-1105 15-1119 AA362851, AI499938, AW085790, AA488903, AL043009, AW069227, AA443390, AA569648, AW304580, AA281461, AA547979, AL041706, AI688846, AW022934, AW021161, AW193432, AI634187, F36273, AI510838, AI344844, AW269488, AI061334, T47138, AI049709, AI471481, AW193265, AI963720, AI560085, AL079869, AI287651, AL046409, AW438643, AI341664, AI350211, AI755214, AI369580, AI334443, AI279165, AI148277, AW162489, AW270270, AI619997, AA581903, AW338035, AA350859, AW338021, AI754567, AI375710, AA610491, AI457313, AI613280, AI754105, AI355206, AA493708, AL079645, AI587583, AL119691, AI587565, AW270716, AW148792, H73550, T74524, AI431303, AW276827, AA714453, AI635279, AA169194, AA348311, AA483606, AI291268, AI291124, AI380617, AI287451, AW419389, AI687343, AA631507, AA167792, AI801600, AI053672, AA570740, AI371070, AA758934, AI284640, AI270117, AI801591, AW327868, AI340453, AI761471, AA181773, AI801482, AA599920, AI589230, AL135377, AA491814, AI471572, AI744995, AI379719, AA177061, AI912322, AI635819, AI017024, AW022379, AI733856, AW023672, AL118991, AI583142, AA577906, AW245354, AA847499, AI537506, AI446259, AA719805, AW237905, AI860020, AI300054, AC005730, AC002377, AC007240, AC005180, AC004531, AL049588, AC008372, AC005486, AL049776, AC006285, AL031602, AC002404, AC009784, AC005274, AC004453, AC004019, AC006064, AP000049, AL035659, AC005620, AC004596, AC005081, AC004859, AC005215, AP000311, AL121653, AC006111, AL080243, AC004890, AC005529, AP000511, AL022163, AC005015, AL021707, AP000555, AL139054, AC004707, AC016025, AP000501, AC005280, AC006449, AL133246, AC006312, AC007308, AC004650, AC005011, AL121578, AC006544, AC000052, AC005913, AL050332, AC005288, Z98752, AC012599, AC006254, AC006597, Z84487, AC006130, AC002350, AF196969, AC004028, AC005520, U95742, AC006596, AC004150, AC007227, AL132712, AL049643, AC003957, AC003982, AC005778, AC005088, AC005488, AL034549, AC006057, AC006538, Z98885, AC006480, AP000088, Z92542, AF053356, AL133448, AC002091, AL121655, AL035072, AL109984, AJ229041, AC004967, AC004745, AC005071, AC007546, AC006543, AC008044, AL133289, AF165926, Z98044, AC005924, AP000557, AL031311, AC004922, AL049692, U80017, AC005874, AF134471, AL031589, U89337, D87675, AC008150, AF117829, AC004638, AC005031, AC007055, AL022165, AP000034, AL049766, AC007666, AC004985, AL033525, U85195, AL031295, AC004797, AL009181, AJ246003, AC005089, AC005899, AL035423, AL021453, AL135744, Y14768, AC004526, AC002059, AC004799, AC004675, AC009516, AC000025, AF049895, AC004913, AP000556, AC005291, AP000356, AL121658, AC004812, AC006079, AF200465, AP000513, AC007919, AF205588, AC007292, AC007536, AC000075, AC002301, AF001549, AC007731, AC004686, AC005324, Z97352, AC002395, Z82215, Z98742, AF108083, AJ011930, AC003101, AC007999, AC005500, AL022326, AP000031, Z86061, AP000558, AC005028, AL021392, AC002369, AC005519, AC004764, AC002996, AB000882, AC003104, AC008115, U47924, Z94044, AC007371, AE000658, AC005057, AL022320, AF088219, AF111168, AC004033, AP000512, AL022328, AC007216, AF029308, U91319, AC005666, AL049636, AC007684, AL049709, D88270, AL009179, AC005632, AL109628, AC010168, AC006966, Z98200, AC004477, AF001552, Z85987, AC005736, AC004087, AC004821, AP000359, AC005722, AC000353, AC004999, AC005600, Z85996, AC007207, AF134726, AP000143, AL031427, AL033521, AC005387, AF190465, AL021937, AC005212, AC005229, AC005562, AL096701, AL031774, AC005696, AC006001, AC006211, AC002425, AL031255, AC018633, AJ003147, AC007011, AC005911, AL049869, AL022322, AC020663, Z94056, AC007406, AC005531, AC002365, AP000505, AC004933, AJ010770, AL035681, AL035422, AL096712, and Z95114. HONAL50 2259 723571 1-545 15-559 W86672, and AA362593. HONAD65 2260 747152 1-290 15-304 AA362745, and AA085323. HONAD02 2261 859016 1-1041 15-1055 AA362710, AI873444, AA889371, AW376675, AI261617, AW376657, AW390112, AW376696, AI857990, AI431824, AI963829, AI632752, AI590245, AI953341, AW376640, AA888092, AF118395, and AF118855. HOGEW23 2262 973221 1-595 15-609 AW392670, U46349, AL119355, AW363220, AW384394, AL119443, AW372827, AL119319, AL119497, U46345, U46350, AL119341, AL119457, AL119399, U46347, AL119391, U46351, AL119324, U46346, Z99396, AL119484, AL119363, AL119444, U46341, AL119483, AL119335, AL134920, AL119439, AL119396, AL134902, AL119522, AL134527, AL042433, AL037205, AL119496, AL119418, AL039912, AL134538, AL119488, AB026436, AR054110, A81671, AR069079, AR060234, and AR066494. HOGDQ03 2263 922578 1-402 15-416 AA863353, D62887, AL119319, AL119355, AL119391, AW392670, AL119464, AL119324, AL119341, U46349, AL119457, AL119484, AW372827, Z99396, AW384394, AW363220, U46350, U46341, AL119497, AL119483, AL119363, U46347, U46351, AL119443, AL119444, AL119522, AL042984, AL119396, AL119439, U46346, AL134536, AL119335, AL037205, U46345, AL134902, AL119401, AL134538, AL042433,AI142131, AB026436, and AR054110. HOGCW89 2264 973227 1-780 15-794 AW392670, AL119355, U46349, AL119319, AL119483, AL119341, AL119457, U46351, AL119324, AW372827, U46346, AW363220, U46350, Z99396, U46347, AW384394, AL119443, AL119484, AL119363, AL119391, AL119444, AL119497, AL119418, AL042984, U46341, AL119439, AL042433, AL037205, AL119335, AL134902, AI142131, AL119401, AL119522, AL134536, AL134538, U46345, AL119399, AL134525, AL119396, AL119496, AL119464, AR054110, AR060234, AB026436, AR066494, A81671, and AR069079. HOGCT13 2265 657284 1-751 15-765 R54129, andR14999. HOGCR31 2266 463874 1-592 15-606 R70301. HOGCR10 2267 964761 1-687 15-701 N52836. HOGCQ54 2268 859076 1-594 15-608 AA236968, AA761761, AA236930, AI823768, AI990131, AA195511, AW297141, AF139471, AP000547, and AP000365. HOGCH05 2269 930813 1-663 15-677 N57691, H58749, and AF134882. HOGCE07 2270 859077 1-531 15-545 R17461, and AA614012. HOGCD61 2271 761991 1-465 15-479 R56752, F06590, AA338081, R15941, AA453210, T74962, R14640, F12752, AL117612, and AC009514. HOGCC63 2272 745130 1-430 15-444 AA021008, and AA057308. HOGCA65 2273 750308 1-547 15-561 T97004, AI076315, and T87200. HOGBJ26 2274 847191 1-394 15-408 AA923566, AI754510, AI018234, W68384, AI376764, AI335263, AI769932, AI143581, AA456821, AI949857, W18181, AW305247, AI613113, W68500, H30442, AI190109, H11954, R44819, AA873841, AA767140, R16196, H30441, R16198, T16809, and H88480. HOGBE27 2275 682232 1-281 15-295 AA025299. HOGAM56 2276 908904 1-960 15-974 AI631040, and AA594778. HOGAI73 2277 764490 1-412 15-426 AA258075, AC007688, AC004878, AL133500, and AC006241. HOGAI26 2278 681919 1-497 15-511 H48638, W03175, and H58992. HOGAH71 2279 760431 1-355 15-369 AA055623. HOGAG57 2280 734848 1-621 15-635 AA737314, AA682280, AA010792, AA143573, AA953433, H23757, AA011221, AA745273, AA188649, and AF205935. HOGAD77 2281 772319 1-563 15-577 R85394, AI078027, and R84629. HOGAC69 2282 756713 1-694 15-708 AA594141, AI740524, AI419995, AA903241, AW069464, AI340359, AW194431, AI017580, AA858303, AI803720, AA074277, AL044093, AI921819, AI557117, AI190687, U69197, AI802592, AA889669, AI983007, AA207148, H11397, H96787, H16250, AI814813, AA427905, AI333376, AI268881, AI061243, AI963361, AA191622, AA846829, AI819766, AI190464, N51259, AA669068, AI150891, AA157806, AA135198, AA206434, AI925182, AL044094, AA135111, AW169049, AA034036, AI472734, AA135106, AW272442, N22707, AA609322, AA910279, AI262450, N71642, AI362641, N66837, AI138341, AA847184, N45294, T15527, AA907298, AI433939, AW263961, N67513, AA658226, T89105, AW183696, AA931425, AW105669, AA541311, AA160287, AA578579, AW069630, AW166420, AW021379, AI799396, AA610333, AI216722, AA620459, AA741223, AA704085, AI970644, AI864144, AA588415, F10050, T94064, AI277023, AA904093, AA747271, AA593048, AI160470, AW090441, AI445175, AI873497, Z41528, D20243, T10553, AA043331, T11277, AI383429, AI868926, AA886271, AA613110, AA043332, AW384062, AI687569, R23931, R00190, N31181, AI917566, AI123136, AJ132258, AF061940, AF061938, AF061941, and AF061939. HOFNW81 2283 789232 1-499 15-513 AW149722, AA452511, AA452655, AA359415, AI802674, AA341041, AA852853, AA149479, AW247428, AA359435, and AF104222. HOFNW69 2284 533713 1-658 15-672 AI694574, AI299316, AI916308, AI809867, AI683372, AI650987, AI216772, AI700681, AI634004, AL042841, AI968717, AL042842, T67552, AA031777, AA778375, AI290605, AI806369, AI379501, AI433552, AI934582, AI635280, AI917817, AI968679, AW205433, AA640031, T94679, AW073063, AA400802, AI560612, T94326, AA736650, R44761, T55416, and C01874. HOFNW68 2285 753048 1-142 15-156 HOFNW65 2286 815822 1-417 15-431 D38026. HOFNW45 2287 720755 1-104 15-118 HOFNW07 2288 953436 1-397 15-411 HOFNU50 2289 724437 1-465 15-479 W00809, H71229, AI688559, and AC005412. HOFNL96 2290 888569 1-366 15-380 HOFNI90 2291 788947 1-353 15-367 HOFNI85 2292 784366 1-303 15-317 HOFNI72 2293 760643 1-332 15-346 HOFNI71 2294 760392 1-353 15-367 HOFNI58 2295 859094 1-337 15-351 HOFNJ56 2296 859093 1-396 15-410 HOFNI42 2297 713816 1-290 15-304 HOFNJ37 2298 859102 1-346 15-360 HOFNI33 2299 859103 1-333 15-347 AW248328. HOFNI32 2300 699299 1-364 15-378 HOFNI10 2301 964682 1-305 15-319 D86969, AF127774, and Z83822. HOFNI02 2302 917347 1-189 15-203 HOFNC80 2303 835718 1-353 15-367 HOFNC79 2304 774037 1-411 15-425 HOFNB63 2305 613681 1-307 15-321 AI251832, AA622670, AA888154, AA994676, AA890531, AI141391, AI025322, AI587539, AA628616, AI338781, AW055053, AI147905, AA040767, AW272916, AI192845, AI338006, AI095692, AI144012, AI051360, AI205873, AA970491, AI374939, AI678799, AI869782, AI423147, AA973818, AI439825, AI520772, AW438950, AI694600, AI040992, AA935932, AA418706, AI091801, AI750219, AA425949, AI636432, AI079960, AA872649, AI061431, AA779735, AW275907, AA576868, H97795, W61292, AA814520, AW440409, AA812517, AI274100, AI128370, AA861315, AW169816, AA026344, N50703, AW440389, AA147089, AI887699, H25461, AW270131, AI201428, AA099879, AI080203, AA173333, AA147095, Z21890, AW023278, AA780492, R52994, AI630374, AA173438, AW189739, AI890908, AA714013, R31084, H28954, AA037330, AA468886, T06660, AI217891, H07854, AA176908, Z41333, AI949085, D57501, AI351274, AA037329, AI864848, R34332, AA885673, AI079089, R80423, AA599378, AA464883, AI784205, R41882, AI864749, AI860102, T04889, T15425, AW189623, AA418715, AI982539, D53365, AW237884, T35361, AA284089, T25943, AA629755, W52902, H27251, AA489825, AI718058, AF000982, and U42386. HOFNB55 2306 731801 1-54 15-68 HOFNB51 2307 725684 1-419 15-433 HOFMU70 2308 489858 1-142 15-156 HOFMU67 2309 743184 1-1345 15-1359 AI394585, AI347406, AW300884, R60771, AI609950, N94357, AA768117,AA830837, AA778534, AI024114, AI340016, AI675916, AW027671, AW027648, AA983621, AI272784, AA918495, AA724472, AI335706, AI421130, AI340312, AI632085, AI159997, F35349, R49581, W52231, R36293, AL119324, AI431351, AL119399, AL119464, AI432666, AL119457, AI431346, AI432662, AI431243, AL042544, AI623302, AW392670, AI431354, AI431307, AI431316, AW372827, AL119443, AI432644, AI432649, AI431337, AI431312, AI432674, AL119355, AW128897, AI791349, U46351, AI432651, AI431230, Z99396, AI492509, U46350, AI432661, AL119319, AL134902, AI431238, U46349, AW081103, AI432675, AI431347, AI432653, AL119483, AI431328, AI432654, AI432655, AI431310, AW384394, AI432650, AI432677, AW363220, AL119497, AI432665, AL119484, AL119363, AL119391, AI431248, AI431330, U46347, AI432647, AI492519, U46341, AL119444, AL119401, AI432657, AL119341, AI431241, AI431345, AW128900, AL119418, AL042450, AI432643, AI431353, AI492510, AI431247, AL119439, AI431357, AL119522, AL119396, U46346, AL119335, AL037205, AI432672, AL134536, AI492520, AI431751, AI431255, AI431254, AI432676, AI432673, AI432658, AL134538, AW129223, AL134533, AL042984, AL043033, AI431308, AL119496, AL134525, U46345, AI431231, AI431257, AI432664, AI431314, AI431236, AW128846, AW128884, AL042433, AL042614, AI142131, AL043029, AI431358, AL134542, AL043011, AL043019, AL042542, AL042965, AL042975, AL043003, AL042551, AR066494, AB026436, AR060234, AR054110, Y17793, A81671, AF064854, and AR069079. HOFMU29 2310 824242 1-1023 15-1037 HOFMT55 2311 888552 1-226 15-240 HOFMT45 2312 891512 1-292 15-306 HOFMS43 2313 947973 1-360 15-374 HOFMS09 2314 972725 1-447 15-461 AW392670, U46347, AL043003, AL119439, AL119484, AW363220, AW384394, AL134132, AL119457, AL134530, AL134519, AL134531, AL134527, AL134528, AL043147, AL119522, U46351, AL119324, U46350, AL134536, Z99396, AL134533, AL134902, AL119497, AL119443, AL134153, AL119496, AL119396, AL119399, AL042989, AI142134, AB026436, and AR069079. HOFMP09 2315 943358 1-545 15-559 HOFMI25 2316 491360 1-412 15-426 H16801, and AW080504. HOFMF82 2317 693987 1-155 15-169 HOFMF81 2318 788733 1-383 15-397 AA425224, N23786, N36074, AA779556, T66056, H29680, R60682, AW367327, T77025, H08571, F13183, Z43231, R19696, AI668657, AI734217, R54134, R18168, F12174, F08075, F07164, AA642020, F06393, AA314127, T33549, R12223, W20302, F07553, F05907, F05321, F05322, F05267, AF182814, and AJ243721. HOFMF19 2319 888780 1-445 15-459 HOFAF25 2320 942367 1-981 15-995 AA829001, AA837772, AC008154, and AC009275. HOFAD78 2321 886485 1-689 15-703 Z99396, AL038837, AL037051, AL036725, AA631969, AL039074, AL036418, AL039085, AL036858, AL039564, AW384394, AL039156, AL038509, AL039108, AW392670, AL039109, AL039128, AW363220, AL036924, AL119497, AL037094, AL039440, AL039659, AL038531, AL036196, AL039625, AL039648, AL045337, AL038447, AL036767, AL037082, AW372827, AL037526, AL036190, AL037639, AL039678, AL039629, AL119443, AL039423, AL036238, AL039150, AL038520, AL040992, AL042909, AL119391, AL119319, AL037077, AL119457, AL119396, AL119324, U46341, AL119483, AL037726, U46347, AL119484, AL119363, AL119341, AL119335, AL119355, AL038851, U46350, AL119522, U46351, AL039410, U46349, AL119496, AL036998, AL037615, AL037085, AL036733, AL039386, AL036268, AL119418, AL119444, AL042450, U46346, AL119399, AL134533, AL037027, AL037178, AL042614, AL045353, AL037205, AL119439, AL036765, AL036679, AL042965, AL042975, AL134528, AL036973, AL119511, U46345, AL036191, AL042984, AL119488, AL134527, AL042551, AL134538, AL036719, AL042970, AL043003, AL042542, AL042544, AL043019, AL043029, AL037021, AL037054, AL036836, AL036158, AL119464, AL036774, AL036886, AL036999, AR060234, AR066494, AR023813, A81671, AR064707, AR069079, AR054110, AB026436, and AR064706. HODKG07 2322 951875 1-662 15-676 AA653929, F20611, and F20551. HODJU05 2323 929321 1-471 15-485 AL135682, AA446265, T26578, H06982, C14389, C14331, D80195, D59502, D59619, D80210, D80240, C15076, D80164, D80212, D80022, D80166, D80219, D80193, D81030, C14429, D59467, D59275, D80227, D81026, D58283, D59859, D80391, D59787, D51423, D51799, D80253, D80045, D80043, AA305578, D80269, D80038, D80196, D50979, D80188, D59889, D59927, AA305409, D80248, D57483, D59610, D80378, D80366, D51022, D50995, D80024, AA514188, AW177440, AW360811, D80241, D51060, AW178893, D80133, D80522, D80251, D80132, AA514186, T03269, AW179328, C14014, C75259, D80302, AW377676, AW378532, AW375405, C05695, AW177501, AW177511, AW377671, D80268, AW178762, D80134, AW366296, D80439, AW360844, D51250, AW360817, AW375406, D58253, D80064, AW378534, AW179332, AW377672, AW179023, AW178905, AW178775, AW369651, D80168, F13647, D59373, AW352158, D59695, D80949, AW352117, AI910186, AW352171, AW176467, C14407, AW178906, AW352170, AW177731, D80247, AW178907, D52291, AW179019, AW179024, AW177505, C14298, AW179020, AW360841, AW178909, AW177456, AW352174, AW179329, AW178980, AW177733, AW378528, AW178908, AW178754, AW179018, C14227, D80157, T11417, D81111, D51103, AW179004, AW179012, AI905856, AW178914, AW378525, AW367967, D59503, AW177722, AW177728, D51759, AW179009, AW360834, AW178774, AW178911, AW378543, AW352163, D58246, C06015, AW378540, C14077, Z21582, D59627, D80258, AW178983, D59653, AW178781, T48593, D58101, C03092, AW352120, AW177723, AA285331, D51213, AI535850, D51097, D45260, C14975, AW378533, C14344, D80014, AA809122, AW367950, AI557751, AI525923, H67854, H67866, AW177508, T03116, AW178986, D45273, AW177497, D80228, D59317, AI535686, AW177734, AI525917, D59551, C14973, D51221, AI557774, D59474, AI525920, D60010, AA514184, D60214, AI525227, C13958, T02974, T03048, C14957, C14046, AI525925, AI525242, AI525235, D51053, AI525912, AW378542, F13796, AI525215, AW378539, C16955, C05763, AI535961, Z33452, AI525237, AI525222, AC007686, A84916, AJ132110, A62300, A62298, AR018138, AF058696, AR008278, AB028859, X67155, Y17188, D26022, A25909, A67220, D89785, A78862, D34614, Y12724, I82448, D88547, A82595, X82626, AR060385, AB002449, A94995, AR016808, AR025207, AR008443, I50126, I50132, I50128, I50133, AR066488, AR016514, A45456, AR060138, I14842, A26615, AR052274, AB012117, AR066490, Y09669, A43192, A43190, AR038669, AR066487, I18367, A30438, X68127, AR054175, D50010, Y17187, A85396, D88507, AR066482, A44171, A63261, A85477, I19525, A86792, AR008277, AR008281, X93549, AR008408, AR062872, A70867, AR016691, AR016690, U46128, D13509, I79511, A64136, A68321, AR060133, U79457, AF123263, AR032065, X72378, and AR008382. HODJL04 2324 926200 1-314 15-328 AA649610, AA761836, and Z97195. HODHK07 2325 952193 1-521 15-535 H03808. HODHG11 2326 966063 1-704 15-718 AI208573. HODGL88 2327 859300 1-655 15-669 W78906, N87704, R01599, and AF131819. HODGJ02 2328 918476 1-466 15-480 N77172, AA247874, and AC004492. HODFY10 2329 963350 1-461 15-475 AA426476, and AA424622. HODFX19 2330 842138 1-733 15-747 AI376921, AA975777, AI001802, AI986107, AI277187, AA024836, AA814148, AA946575, AI823500, AI934527, R01773, AA069448, AI214374, AI261766, AI740547, AI149941, R67552, AI761204, H22357, AA991800, AI394623, AI090982, T50900, AA634859, AA931388, and AF055496. HODFX12 2331 969588 1-320 15-334 AI936005. HODFX04 2332 926278 1-479 15-493 AA976439, and N77643. HODFW95 2333 795281 1-798 15-812 W93859, W93898, AA829836, and AF086497. HODFW40 2334 859320 1-542 15-556 AA972774, and AI694547. HODFR85 2335 783789 1-489 15-503 N76385, AA954669, N71863, AI041474, and AI937830. HODFL37 2336 948703 1-450 15-464 HODEJ11 2337 966065 1-476 15-490 AA242986, and AA242787. HODFI66 2338 974317 1-523 15-537 HODFH45 2339 974916 1-606 15-620 AL121595. HODFG82 2340 779191 1-544 15-558 AI733904, and AA160258. HODFF88 2341 974911 1-1843 15-1857 D80164, D59502, D80193, D80195, D59275, C15076, D80227, D58283, D80022, D80166, D81030, D59859, D51799, D59619, D80210, D80391, D80240, D59787, D51423, D80253, D80043, D80269, D50979, D80212, D80038, D80196, D80024, D80219, D80188, C14331, D59467, D57483, D59927, D80378, D80366, C14389, D59889, D50995, D80045, D59610, AA305409, C14429, D80241, D51060, T03269, C14014, AW178893, C75259, AA305578, D81026, D59695, D51022, AW179328, D81111, AW178775, D80134, AW378532, AW177440, D51250, AW352158, D80268, F13647, AA514188, AW369651, D80251, D80522, D51079, D80248, D80949, D58253, AW178762, D80168, D52291, C14227, AA514186, AI905856, AW177501, AW177511, D80133, Z21582, AW360811, C05695, C14298, AW352117, D80064, AW176467, AW375405, AW378540, C14407, AW377671, D51097, AW366296, D80302, AW360844, AW360817, AW375406, AW378534, AW179332, AW377672, AW179023, AW178905, D80132, AW360834, AA285331, D80439, AW352171, AW377676, AW178906, AW352170, AW177731, D80247, AW178907, AW179019, AW179024, D51103, AW177505, AW360841, AW179020, AW178909, AW177456, AW179329, AW178980, AW177733, AW378528, AW178908, AW178754, AW179018, AW179220, AI557751, AW179004, AW178914, AW378525, AW352174, T11417, D80157, AW177728, D59627, D51759, AW367967, AW178774, AW178911, AW378543, AW352163, D59503, D80258, D80014, C06015, AI557774, AW178983, AW352120, T03116, AW178781, T48593, D58246, C14077, D59653, AW177723, D58101, D45260, AI525923, AW178986, AW367950, C03092, AA809122, H67854, D59551, H67866, C14975, T02974, AW378533, AW378539, D51213, AW177734, AI535686, D59317, D51221, AI525917, C14973, AA514184, C14344, D45273, AI525925, AI525920, D59474, AI525227, D31458, C14046, AI525242, AI525235, T03048, AI525912, AW378542, AI525215, AI525237, C16955, C05763, Z33452, AI535850, AI535961, A84916, AJ132110, A62300, A62298, AR018138, X67155, Y17188, D26022, A25909, A67220, D89785, A78862, D34614, D88547, AF058696, X82626, AR008278, AB028859, AR025207, I82448, Y12724, A82595, AB012117, AR060385, AB002449, A85396, AR066482, A44171, A85477, A94995, X68127, I19525, A86792, X93549, AR008443, AR016808, U87250, I50133, I50126, I50132, I50128, AR066488, AR016514, AR060138, A45456, A26615, AR052274, I14842, Y09669, A43192, A43190, AR038669, AR066487, A30438, AF135125, D88507, AR066490, D50010, AR054175, I18367, Y17187, A63261, AR008277, AR008281, AR008408, AR062872, A70867, AB033111, AR016691, AR016690, U46128, D13509, AR060133, I79511, AR064240, A64136, A68321, U87247, AB023656, U79457, AF123263, X93535, and AR008382. HODFE04 2342 926999 1-429 15-443 R83400. HODFD73 2343 909812 1-603 15-617 AL050332, AF050183, AF058790, AF058789, AF048976, and AB016962. HODFC79 2344 774156 1-415 15-429 W93152, and AW272240, HODEZ45 2345 974337 1-516 15-530 HODBU01 2346 915167 1-508 15-522 R93800, T77247, and R08385. HODET07 2347 952194 1-410 15-424 H80608. HODES10 2348 963474 1-186 15-200 AA076702, and AC004928. HODEO35 2349 859364 1-124 15-138 AA595928, AA461421, and AP000553. HODEK82 2350 779245 1-673 15-687 AI660692, H96927, and AI471598. HODEA14 2351 859375 1-664 15-678 N44316, L44479, AW016606, AA524565, AI809352, and AC004821. HODDX64 2352 745810 1-460 15-474 N71060, T99547, AC001228, U51281, and Z97056. HODD589 2353 531075 1-476 15-490 N52086, and AA927904. HODD574 2354 765863 1-221 15-235 T77437, and AW292096. HODDF37 2355 420051 1-536 15-550 AC002559. HODDE02 2356 920961 1-419 15-433 AI378347, AI082130, and AA563785. HODCZ64 2357 745966 1-391 15-405 C14014, D80253, D51060, D80366, AA305409, D80439, AA514186, D80166, D59619, D80210, D80240, D80188, D59275, D81030, D80133, D80247, D81026, D59859, D80024, D80212, D51799, D80164, D80219, C14389, D51423, D80043, D57483, D80022, D80391, D59787, D80251, D80268, D80195, D58283, C15076, D80248, AI525923, D59610, C14331, D59502, D59467, D80038, D80227, D80157, D80196, D80269, D59889, D51022, D50979, D80522, D50995, D51103, D59653, D59927, AA305578, D80193, D80045, C06015, D80241, D80302, AA514188, D51759, AW360811, D80378, AW177440, C05695, AW178893, C14429, D59373, T03269, C75259, D45260, AW377671, AW375405, H67854, T03116, D81111, C03092, H67866, AW178906, AW366296, AW360844, D51221, AW360817, D58246, AW179328, AA809122, T48593, AW375406, AW378534, AW179332, T11417, AW377672, AW179023, AW178905, D80064, AW177731, AW378528, AW178762, AW179019, AW378532, AW177734, F13647, AI525917, AW177501, AW177511, AW360834, AI535686, AW179020, C14227, D80258, AW377676, AW352171, C14957, Z21582, D59503, D59317, AW352170, D80014, D59474, AW178907, AW177733, AI525920, AW178908, AW179024, C14973, C14344, AW378533, D59551, AA514184, D51250, D58101, AW360841, AW352120, AW177505, D60010, AW178775, AW367950, AW178909, AW177456, AW179004, AW179329, AW178980, AW176467, AW178986, AW178914, AI525235, AW178774, AW178754, AW179018, AW352158, D80949, D59695, AW352117, D52291, D59627, D60214, AI525215, D51079, AI525227, C14046, AI557774, C14407, AI557751, D80228, AI525912, AW179009, AW179012, AI525925, AW178911, AW378543, AW378525, AW378540, AW177722, AW352163, AI525242, AA285331, AI525222, AW177728, D51213, AW378539, Z30160, D45273, D80168, C16955, C14298, AW378542, C05763, Z33452, T02974, AW178781, D51053, AW360855, H67858, AI525237, AI910186, C04682, T02868, AW369651, C13958, AI525928, C14077, AI525903, D31458, AI525216, AI525238, D50981, N66429, AI525228, AW177508, AW177497, T03048, AI525239, A62298, AJ132110, A84916, AB028859, AR018138, AR060385, AR008278, A62300, A82595, AF058696, AB002449, I50126, I50132, I50128, I50133, AR016514, I14842, X67155, AR060138, A45456, Y17188, A94995, AR054175, D26022, A26615, AR052274, A43192, Y12724, A43190, AR038669, A25909, AR066488, Y09669, AR066487, Y17187, A67220, D89785, A78862, D34614, A30438, AR008443, AR008277, AR008281, A63261, D88547, AR062872, A70867, AR016691, AR016690, U46128, D50010, X82626, A64136, A68321, AR008408, I79511, D13509, AR025207, X68127, AR060133, AF123263, AR032065, and Z82022. HODCZ39 2358 875811 1-410 15-424 W04443, AA132310, R78009, and AC012627. HODCY73 2359 764543 1-447 15-461 AI816780, AI458427, AI828772, AA970754, T90292, AA723211, C15270, R55335, AI700847, AI800369, F04197, AA172179, R48809, AA634235, H26791, AW137473, R48921, AI056206, and AL021920. HODCY32 2360 859543 1-514 15-528 HODCW83 2361 781287 1-194 15-208 AI570526, W35195, AA425012, AI190032, AI949009, AW236490, AI632129, and AI695985. HODCV61 2362 868291 1-760 15-774 HODCO15 2363 660502 1-608 15-622 W00867, AL045871, AL046306, AB014529, and AF176555. HODCJ84 2364 973286 1-680 15-694 HODCC05 2365 932633 1-772 15-786 AA773910, W28027, AP000549, and AC006946. HODCA90 2366 792611 1-356 15-370 AA005005. HODBZ85 2367 784526 1-370 15-384 H70407. HODBX08 2368 960178 1-617 15-631 W87564, and AA837795. HODBU72 2369 766284 1-336 15-350 AA503323, H89112, H89218, and AF086031. HODBK84 2370 859558 1-614 15-628 AA682892, AC002116, AC007537, AC006071, AL031432, AL021366, AL050332, AC004921, AC004841, Z93016, AC002477, AC006960, and AC005480. HODBF61 2371 742114 1-240 15-254 HODBF40 2372 529387 1-325 15-339 AF179633. HODBF33 2373 702750 1-179 15-193 N78634, AI655262, AI219603, AI337066, AW016620, AW299342, AA806525, AI343418, and AA314128. HODBF17 2374 529389 1-338 15-352 AW297233. HODBD93 2375 792579 1-510 15-524 AA150484, AA156687, AI915919, T24517, and AL122023. HODBD73 2376 764670 1-503 15-517 R95802. HODBC42 2377 529635 1-560 15-574 AA031438, AA031560, AI335617, and AC004067. HODBA48 2378 721931 1-662 15-676 N35773, AA020962, AA429989, AA019518, and AC005046. HODAZ21 2379 826693 1-606 15-620 D80195, D80022, D80043, D58283, D80302, D80038, D50979, C14389, D59467, D80164, D59275, D80253, D80227, D59502, D50995, AA305578, D51423, D80247, D80522, D80439, D80188, D81026, D80269, C14014, D80366, D59859, C14331, D80166, D59619, D80210, D51799, D80391, D80240, D59610, D59787, AA305409, D51022, C15076, D81030, D80248, D80212, D80268, D80193, D80196, D80045, D80219, AA514188, D59927, D80024, D57483, D80378, D51060, D51103, D59889, D80133, AA809122, D80241, AA514186, D80157, D80251, AW360811, AW177440, D51759, C06015, C14429, AW178893, T03269, D45260, AW377671, AW375405, C75259, AW178906, H67854, D59653, AW366296, AW360844, AW360817, AW179328, T48593, AW375406, AW378534, AW179332, C05695, AW377672, AW179023, AW178905, AW177731, AW378528, AW178762, AW179019, D59373, AW378532, AW177501, AW177511, AW179020, AW352171, AW377676, H67866, AW352170, T11417, C03092, AW178907, AW178908, AW179024, T03116, AI525923, AW176467, D51250, D59317, F13647, AW360841, AW360834, AW352120, AW177505, D52291, AW178775, AW367950, AW178909, AW177456, AW179004, AW179329, AW178980, AW178986, AW178914, AW178774, D80258, AW177733, AW178754, AW179018, AW352158, D59503, C14973, AW352117, D58246, D81111, AI525917, D80014, D60214, C14227, D80064, C14344, AW378533, D59695, C14957, AI525227, AW179009, AI535686, AW179012, D51221, D59474, AW178911, D59627, AW378543, AW378525, AW378540, AW177722, AW352163, D60010, D59551, AW177734, AW177728, AI525920, and AA514184. HODAX45 2380 723449 1-384 15-398 R07196, and N59556. HODAV84 2381 592179 1-623 15-637 HODAV24 2382 679165 1-392 15-406 H60974, R07912, N22871, and H84048. HODAK55 2383 745532 1-411 15-425 R83642, T81960, AW068239, H60497, N44274, AA318156, H10590, AW404818, AA642219, AA773468, N72512, W85743, AA009995, T92075, R12889, AA853594, W21986, AI686932, AW024419, AA743833, AA627696, AW162688, AW003662, AA326440, AW088539, R21041, AA053566, AI955325, AW364257, AI565761, AA337700, AI827029, AL137377, AF100752, AC004472, M30143, Z14044, and AF122048, HODAK05 2384 932639 1-453 15-467 AA132943. HODAE72 2385 529638 1-122 15-136 HODAE55 2386 529637 1-163 15-177 HODAE48 2387 529639 1-116 15-130 D61881. HODAE01 2388 921680 1-306 15-320 H69836. HODAA92 2389 790588 1-239 15-253 HODAA85 2390 784534 1-173 15-187 HODAA80 2391 529560 1-284 15-298 HODAA69 2392 529563 1-334 15-348 AC007030. HODAA54 2393 859582 1-237 15-251 HODAA34 2394 529570 1-300 15-314 AL034553. HODAA21 2395 859583 1-502 15-516 T48184, and AL035530. HODAA15 2396 523382 1-119 15-133 AL022068. HODAA07 2397 954157 1-106 15-120 HODAA04 2398 927711 1-291 15-305 HOCPU05 2399 928651 1-753 15-767 AI189844, AI201116, AA609456, AA584808, AA780934, AI219194, and AL022721. HOCPH02 2400 917453 1-468 15-482 AI610771, AI469844, N40199, AA588746, T70544, N39125, AI937318, AI500487, R37094, R16096, AI748890, and AA258667. HOCPF02 2401 917630 1-820 15-834 AA280263, AA403050, and AL050343. HOCOV07 2402 951744 1-557 15-571 AA766710, AA767401, AA804400, AI860423, AI753904, AI434653, N66775, AA555232, AI357762, W45274, AA084504, AW249660, AI521525, AA846923, AI571863, AW249541, AW020150, AI926102, AA324559, AA326603, AA632024, AA324059, AW084445, AA773098, AI537368, AW008217, AA582622, AC016025, AC005071, AC005902, AC004820, AC005696, AC005919, AL022327, AC005971, Z82244, AL121652, AC007227, AP000240, AC005089, AC005011, AC006166, AC004386, AL096701, AL021453, AC007899, AC004230, AC004821, AC005920, AC016831, AC002418, AC004034, AL022336, Z99716, AB023051, AC005412, AC002312, AC005913, AL034420, AC004223, AC006449, AL021808, AF109907, AC005907, AL049795, AC004531, AF196779, AL109627, Z94044, Z98941, AC005046, AL035685, AC005081, AC005084, AC007308, AP000501, AC005562, AC004991, AL139054, AP000512, AC005839, AP000500, AC004099, AC005325, AC005399, AJ003147, AC007216, AC005874, AF134471, AL031311, AL023575, AC005206, AL035249, AC004834, AC002554, AC005667, AP000096, AC002492, AC009247, AP000356, AL022326, AL096775, AL022316, AC006040, AC008009, AL034417, AC004967, AC007686, AL033392, AC000159, AL096763, AC004019, AC005736, AC007225, AC002425, AF001548, L44140, AC005015, AD000092, AC005972, AL031133, AL023281, AC000353, AC006953, AL109865, AP000248, AC004150, AP000152, U91328, AC006111, AC006121, AB003151, AL034553, AC005527, AC005041, AC006011, AF196971, AL022165, AC007226, AC005391, AC004797, AC005932, AC008372, AL133163, AC004263, AL050306, Z99714, AC005231, AC004686, AL031284, AC005754, AC004789, AC002310, AC005225, AL035400, AL031680, AC005377, AC005821, AC005682, AL032821, AC005187, AL034379, Z95331, AL021546, AC006581, AC005899, AL031985, AC004253, U52112, AL031295, L47234, AC005829, AR036572, Z93930, AF038458, AP000555, AL033527, AC005094, AC005049, AC005023, AL049839, AL031602, AC005755, AF001549, AL117330, Z93017, AC006441, AL080243, AC004883, AC005280, AC005519, AL035413, AC004560, AL035071, AL096791, AC002350, AC004036, AC004526, Z84480, AC003101, AC004999, AC004491, AC006505, AC005529, AL121655, AL022323, AL049830, AC004033, AC007151, AC005300, AC007371, U96629, AC007666, AL031281, AF134726, AC007546, AL109758, AL035458, AC005057, AP000502, AC009363, AL049569, AC006160, AC003982, AC002126, AL109827, AC005484, AL132712, AC005332, AL049843, U91321, and AC005288. HOCMM01 2403 914464 1-814 15-828 AI348389, AA631606, and AL031297. HOCMI24 2404 878363 1-512 15-526 AA088637, and AW298364. HOCMC01 2405 914552 1-444 15-458 AA699519. HNOJJ12 2406 969077 1-1757 15-1771 AW295026, AI276473, AI553987, H08317, AI955362, H50857, W38821, T75180, R56504, T70815, F12882, R19236, T78969, R20397, T98878, R19579, AI312653, H95935, AA090801, AA361971, AA479557, R92663, AA454914, AI659055, AI480397, AI524497, AI440293, AA788769, AI589107, AA630007, AI380567, AA564726, AI262311, AW027577, AI766536, AI332995, AA044714, AA100613, AI471849, AI674449, AI190957, AI632486, AI891104, AI298730, T77169, R45788, H22006, T86237, R80609, T83221, H20293, AI690130, AA368757, AW179044, W73553, N80081, AA730555, AI338393, and D25218. HNOAD04 2407 926258 1-745 15-759 AA814415, AI378392, N45120, AI457108, AA809495, AA835661, AA831169, AI351546, R43018, R44581, AI824326, and AW136327. HNNNB08 2408 957719 1-346 15-360 AI467919, AI091495, AI219406, R66014, H12334, R71247, R26409, C18360, C18357, H53522, H02244, R78907, AA368929, R67934, R77608, R38313, R34846, R62787, R10842, R67128, R65605, AJ937850, AL046409, AW303196, AW274349, R24497, AI471481, AW301350, AI613280, AW193432, AI375710, AI350211, AI341664, AI537955, AW193265, AI688846, AI345654, W79504, AI365988, AI291268, AI291124, F29989, AI334443, AA350859, AI053672, AW438643, AW406755, AI653886, AW419262, AI499938, AA649642, AI608771, AA133986, AI357551, AI281881, AW338086, AA594145, R24492, AL041690, AI358229, AW406162, R27623, AA719805, T07451, N25296, AA134367, R71050, AI198376, AI475569, AI340453, AI344844, AA654771, AI963720, AA551503, AA613345, T06828, AA599129, AW302013, AI061334, AA581903, AI635818, AI270117, AW079135, F19012, R62788, AA720758, AI284640, AW339687, AI379719, AA533725, AI744995, AW276827, AA630925, AA630030, AI133164, F18974, AW265009, AI262909, AA599920, AA714453, AA664015, AI583594, AI754955, AI801600, F36306, AA179136, AW338500, F03525, AI887483, AA491814, AI357288, AI888008, AI537030, AI564185, AI283911, AI289067, AL044940, AI568678, AI801591, AA577906, AA720702, AI364809, AI708009, AA825357, AI002834, AA074130, AL119691, AL042420, AA352803, AF150152, AW117750, M86143, AA525824, AI246119, AA603445, AA280632, R77905, AA486414, AI889923, AA446657, AA649705, AA970213, AA259245, AA973803, AA368936, AA621858, AI431303, AW088718, AI358343, AI049634, R98967, AI635272, AI370074, AI370094, AA861959, AA713815, AI370057, AW265385, AI471572, T29180, AA678436, AA364429, AL079812, AA513293, AA573020, R97934, AI446464, AI313166, AA810318, AA491762, AA579063, AI827234, AI917156, AI053790, AW338419, AI921188, AI697369, AA346458, AI370878, AI589230, AA629415, AA113376, AI871722, AA639248, AL135405, AA437161, AA664535, AA126777, AA829223, AI888518, AI434695, AW339568, AA641103, AA559290, AI963095, AI471543, AI754658, AI761471, AA623002, AA225072, AW088058, AL048925, AW103981, AI339440, AA621704, AA602528, AW303876, AC005281, AF077058, D83989, X53550, X75335, AF015157, M87919, U18391, U57005, U18392, X55925, U18390, U18394, X54175, X54180, U57006, U18393, X55930, I51997, S77605, U18395, X55926, U57009, U57008, X55932, X54178, U18398, U18387, X54181, U18399, X54176, X55931, 870707, U67801, AF015151, X54179, AF015153, AP000297, AL031668, X60459, AL078581, U18396, U57007, AF015147, X76629, AF015154, AL023882, AF015149, U67827, M37551, AP000044, AP000112, AF015155, U80017, U18400, AL117330, Z22650, Z84487, AC005914, AC004814, AC002350, AL121577, AC005535, AC005245, U66059, U78027, X55927, U57004, AF060568, AF161343, L47228, Z98258, AC004799, U73649, AL049692, AC008163, AC005815, AC004087, AL049745, AC004975, AC004915, AC007278, X53548, U67231, X55928, AL035665, AF123462, AC005907, AC004686, AL031777, X54177, X55924, AC005808, AC004841, AL035361, AL049759, AC007193, AL121825, AL021398, X88791, AL035422, AL079333, AL035460, AP000358, AL021069, AC021092, AC007919, AL049845, U91326, AP000151, AC004650, Z98941, AP000143, AC008115, AC004765, AL008629, AC004455, AC004895, AL049562, Z498 16, Z68332, AC007051, AC000114, AR042836, AC005844, AC002119, AC005034, AF001549, S56773, AC007319, AC006160, AC004010, AL031388, AF023460, AC006511, AL136295, AB020872, AC006512, AC005745, AJ003147, U67831, U67233, AP000010, AC004933, AC007536, AL022238, X55922, AP000014, AC005391, AC006208, AC005837, AF095855, AC006277, AC005370, AC007878, AL034420, AL033397, AC005335, AC005776, AP000114, U95742, AL021808, AL049757, U62293, AL031848, AL035089, AL031286, Z85986, AC006213, AC005257, AC006305, AB020867, AP000090, AC004099, AC006599, AC004884, AC005516, Z69666, AF184110, AC007216, AL078463, AC007151, AL132992, AF053356, M87916, AL050097, U72787, AL121892, AL021453, AL096701, Z93241, U62292, AC005541, AL132985, AC006538, AP000502, AC004016, X55923, AL078477, AL049776, AC008072, AC002299, AC003119, AC005866, Z86061, AC005821, Z93024, AC005696, AC007308, AC005046, Z83846, AC009516, AL079340, U67222, AC007688, AC002544, AC010382, AC004526, AC006040, AD000092, 543650, AC007541, AC008062, Z95114, U67226, AL031255, AC001164, AC006128, Z82180, AL031685, AL136018, M19045, J03801, E01888, E02193, AC004931, AC005251, AL049839, AC004217, AC006960, AC008059, AC002470, AL133163, AC005358, AL133485, and U67229. HNNNA07 2409 899742 1-619 15-633 HNIAB92 2410 683077 1-199 15-213 AL039150, AL039085, AL039156, AL039108, AL039074, AL038837, AL039625, AL039648, AL037726, AL038531, Z99396, AL039109, AL040992, AL039128, AL036973, AL045337, AL037051, AL045353, AL036725, AL039564, AL039678, AL039659, AL039629, AL044407, AL039423, AL042909, AL039410, AL039924, AL039386, AL039538, AL038821, AL036858, AL037526, AL044530, AL036924, AL036196, AL039566, AL037639, AL045341, AL043422, AL038447, AL038025, AL038851, AL036238, AL043445, AL037615, AA514190, AL037082, AL039509, AL036117, AL036767, AL043441, AL043423, AL038983, AL036733, AL036679, AL037077, AL049018, D80134, D59619, T23659, D80196, D80219, AL044125, AL039643, T24119, AL045794, AI535983, AL037178, D51423, AL037027, H00072, D59787, T48598, T24112, H00069, D80253, AL036964, C14227, AA631969, D59927, AL041233, AL040193, AL041296, AL041086, AL043496, AL044162, T23947, AL037085, AL036268, AL041324, AL043538, AL040621, AL041098, AL041163, AL041277, AL041358, AL047012, AL041346, AL040155, AL041197, AL040463, AL047219, AL041227, AL047170, AL040119, AL041292, AL041051, AL040322, AL041131, AL046330, AL041133, AL041159, AL041238, AL041142, T11051, AL040625, AL040510, AL043467, AL044186, AL044037, AL040091, AL040128, AL040168, AL040285, AL040342, AL040332, AL040617, AL045684, AL040745, AL040370, AL043677, AL040839, AL041752, AL041168, AL043775, AL044165, AL043492, AL041602, AL045920, AL037436, AL038838, AL044074, AL041635, AL040458, AL044187, AL040090, AL040294, AL040329, AL040082, AL044272, AL041186, AL040148, AL041730, AL041523, AL043627, AL037443, AL041374, AL040052, AL043845, AL039338, AL044064, AL039316, AL043923, AL042096, AL043814, AL037335, AL043848, AL037435, AL041459, AL043570, AL037343, AL037323, AL041577, AL044258, AL046850, AL038532, AL040768, AL037727, AL046994, AL040414, AL040571, AL046914, AI142134, Z25782, AL041347, AL040464, AL047057, AL047036, AL047183, AL040529, AL039744, AL046442, AL043444, AL037177, AW013814, AL041278, AW452756, AW450376, AL036998, AL045857, AL044274, AL045671, AL079878, AL041096, D80227, AL040444, AL134524, AW135155, AL040553, AL040253, AL045753, AL046392, AW451070, AL036158, AL040263, AL036765, AL038822, D80366, AL042135, AL036191, R47228, D80168, AL040576, AL045990, AL041955, AL039360, Z25783, AL040255, AI547295, AL042898, AL040149, AL036999, AL044199, AL047163, AL045725, AL037279, AL040472, AR062871, AR064706, Y11449, AR063812, AR017907, I84553, I84554, A95051, AR062872, AR062873, A92133, I06859, A20702, AI8050, A23334, A75888, I70384, A02712, A60111, A23633, AR007512, A43189, A43188, A20700, AI8053, E04616, AR043601, AR064707, A84772, A84776, A84773, A84775, A84774, AR067731, A35536, A35537, AR067732, A02135, A04663, A02136, A04664, A58522, A91750, I19525, AI1245, E13740, I66495, I66494, I60241, I60242, I13349, I66498, I66497, I66496, I66486, I66487, U87250, A02710, E12615, AR035193, A07700, AI3392, AI3393, AR027100, I28266, I21869, I08051, A70040, AR054723, Y11447, AR022240, AR051692, D88984, M28262, Y11458, A06392, I68636, A91754, AR031374, A49700, AR031375, A58521, AR020969, Y17188, I18371, AR025207, X68127, A97211, A38214, A44171, I56772, I95540, AR018924, A63067, A51047, A63064, AR018923, A48774, A63072, A48775, AR068507, AR068506, AR015960, AR000007, AR015961, A80951, Y11445, AI0361, X58217, A67220, AF019720, A25909, S70644, D44443, AF130655, AR036905, AJ244003, AJ244004, AJ244005, A98767, A93963, A93964, I63120, X73004, AR038762, I00074, D14548, A04442, A04441, A04448, A04447, I19516, A95052, AB007195, AR043602, AR043603, A95117, A23998, AR000006, A58524, A58523, AR008430, A85477, A85396, AR066482, D34614, AR037157, A86792, A93016, A91965, I12420, AR054109, AR035975, AR035977, AR035978, AR035974, AR035976, AR038286, A60957, A64081, A24783, A24782, A28040, A81878, I92483, S78798, AB012117, I03343, A60968, E00523, Z96142, X15418, Y11923, AF156294, AF156296, AR036903, D28584, I01992, A60985, A60990, E14304, A60987, I19517, A27396, A76773, A22413, I25027, E16590, I26929, I44515, I26928, I26930, I26927, A58525, A49045, E16678, A82653, I25041, E16636, AF118808, X73003, AF156300, AI5078, AJ230906, AJ230872, A22734, I03664, AF096793, X07094, Y11926, I03665, I02252, I04204, AJ230933, V00745, AI8722, AF096810, X83978, A34724, I49890, I44516, A51384, I00077, E03165, E02221, E01614, E13364, S69292, A92636, X92518, I82415, I82416, I00079, A58526, A91753, and I07888. HNJAB73 2411 764172 1-536 15-550 HNIAB26 2412 974750 1-374 15-388 AI241225, AI497916, AI807817, AA287075, AA410717, W69383, W69382, AI167280, H75982, D31247, AA428123, F06544, T78145, AA419308, AA404625, N41831, AA339686, N56216, D31349, AA284532, AI672472, AI366704, AW130807, AI590376, AI274769, AI370149, and AI357616. HNBVH02 2413 917719 1-272 15-286 AI128931, N59410, H71850, H68617, AW026005, H72896, R89336, R89422, AI890794, AL120188, AL117354, Y10196, and AC005535. HNBVC03 2414 922402 1-384 15-398 AA455727. HNBUQ06 2415 933673 1-633 15-647 AI003929, AI203393, AI434650, AI741385, AI239480, AA931467, AI819627, AW183189, F31423, F35609, AA905778, F21790, and AW105048. HNBUO01 2416 914361 1-520 15-534 AA501715. HNBUI10 2417 961734 1-483 15-497 AA954976, AI017449, T89711, W69257, AI150048, AA534436, T89631, AI261657, AW166311, AI627633, AA947856, W69170, AI831660, AI473887, AA909065, AI140835, AA862617, AW449791, AW445047, T89808, and AI795971, HLWFJ69 2418 754476 1-398 15-412 R76168, and R39664. HLWFB01 2419 915399 1-481 15-495 AW451092, AI653216, AA825520, AA828034, AW449785, AA766435, AI379959, AA811081, AA626324, AA251105, AI281315, AI281259, AA252357, AI857494, AA767770, AA961612, AA884914, AI910531, AA883131, and AL117637. HLWEH10 2420 963548 1-600 15-614 N27780, H55265, AC004527, and AL078614. HLWEA90 2421 787632 1-438 15-452 AA397990, W65316, and AC010582. HLWDZ31 2422 917643 1-880 15-894 AA758158, AA143536, AA311020, AW403447, W63569, AA004530, AA683390, N29003, AA209228, H28875, AA305513, AL120940, W77945, AA582670, AA297602, C18645, AW402233, R23541, AA132404, AI752266, AA115891, T19100, AA442767, AI768639, AW183765, AI816897, W38538, AI829074, R19741, T34258, H12133, W44478, F12975, R61604, N34198, AI769388, T34524, AL121186, Z30133, T31614, H06006, T34085, AW188331, AA429756, R80093, T28136, T75286, AI767235, AA126374, T34569, T34148, AI908731, AA864619, F07189, H12905, N33792, T85612, AI685398, T31638, H62867, N69429, N20135, H62527, AA352184, H82866, H09563, T31635, AI224550, AW363446, AA704311, H96883, R10946, N84652, T52635, W56201, D82488, D82543, R26017, AI274027, D82466, R10524, N36374, AI283942, D82428, AA962407, N90094, AA380459, W32740, N36598, AI224548, C06105, AI739339, AA132405, W27707, AA375383, F07315, F05953, AA310081, T78753, AA004531, F05952, AI023176, AI299400, R85616, W20495, H84839, T25453, N83818, T27432, AA054436, T25450, H63569, R53662, AW381573, AA694564, AA130964, AL008725, AF107406, D17446, and S83440. HLWDD01 2423 915378 1-419 15-433 AI266250, AW069227, AI634187, AI457313, R83014, AA610255, R16565, R48980, AI254508, AI251696, AA715508, AA601673, AW090629, AL031296, AC004851, AC004031, AF207550, AL021367, AB022785, AP000065, AL110502, AF165926, AC005280, AC005253, AL009181, AC005828, AL049780, AC004531, U52112, AC005081, AC004890, AL031281, Z97054, AL133246, AC002314, AC006537, AC005940, AD000671, AC008124, AP000553, AF157814, AC004771, AL096791, AL020997, Z95115, AC005324, AC005669, AF134726, AC005209, AB026898, AC006965, M89651, AC004812, AC005291, AP000557, AL031255, AC005146, AC005071, AL109798, AC006241, AC006146, AC002477, AC005702, U80017, AC006449, AJ006216, U73629, AC009516, AC007386, AC004770, AF001549, AL022322, AP000509, D84394, AC005785, Z98044, U07563, AC007283, AC005067, AC007227, AC005231, AL035458, AC002472, AC005342, AC007676, AB017602, AC007055, L78810, AC006539, AC005914, AL023584, AC004560, AC004859, AC003982, AB002353, AL031228, AP000359, AC005086, AC006946, AP000694, AC000025, AC008545, Z95331, AC002115, AC007934, AL034420, AC006530, and AL035659. HLWDB48 2424 856512 1-670 15-684 N42593, AA376825, AW104181, AI215001, N83895, AA374608, AW293450, AB020685, and M77174. HLWCP60 2425 739801 1-419 15-433 AA053452, T07266, and AB020631. HLWCN93 2426 791854 1-682 15-696 R11514, R10440, R97177, AI890794, AL117694, U07563, L47334, AC005023, D83253, AL109802, Z84484, AP000009, AF001549, AC002978, Z84480, AC008989, Z93930, Z98742, AC005071, AC007993, AL031319, U89337, Z98044, AC002070, U91318, AF001552, AC007030, AC003046, AP000299, AL121657, AF039907, AC007450, AF190465, AC005722, AC005602, AL035410, AB000882, AC004750, AC006581, AC003009, AP000229, AP000113, AP000045, AC006543, AL035073, AC003683, AC002400, AC006312, AC008372, AC005409, Z82206, AC007227, AP000555, AC016025, AF053356, AL109967, AC006450, U63721, AC004953, AC005792, AC007773, AC004751, AP000502, AL009181, AP000689, AC006544, L48038, AC004878, AC006030, Z93244, AC004832, AP000696, AB003151, AC003101, AL035587, AL023284, AC004967, AF030453, and AC005231. HLWCN50 2427 723787 1-416 15-430 N47899, H53415, and AL049742. HLWCF83 2428 781069 1-660 15-674 W33061, R98276, and AC004022. HLWCF33 2429 687995 1-489 15-503 AA121582, AW368442, AA188145, AB011132, and U90333. HLWCE47 2430 720156 1-599 15-613 AI207452, AI936201, and AA005229. HLWCB93 2431 623773 1-546 15-560 AW082490, AW157667, AI032875, AC005899, AC005231, AL109623, AC006449, AL049539, AL049779, Z98941, AC006312, AC004383, AC004491, AJ003147, AC007157, AL139054, AC006285, AC006450, AL031276, AC005792, AC005015, AC005086, AF196779, AC002470, AC002287, AC004913, AC004876, AL034549, AL133355, AL035587, AP001054, AL035413, AL109827, AC007546, AL049780, Z98200, AL109984, AC007151, AC005081, AC004813, Z85986, Z84469, AC007308, U91323, AC005902, Z84487, AL049709, AC007055, AL022336, AL031281, AF024533, AC005412, AC005585, and AC005484. HLWBX42 2432 917920 1-445 15-459 AA427651, AI143307, AW262122, AA703186, AI659343, AI341865, AI336119, AW237136, AI298482, AI090247, AI333715, AI803140, AA579615, AI056488, AA779669, AA620404, AI089588, AI278727, AW090136, AI811913, AA427568, AI911844, H91654, AI610128, AW129695, AA593874, AI870923, AA651783, AA112592, AA058719, AI400566, AA506145, AA622437, AA478461, AA862138, AI784558, AI589813, AW007077, AW169327, AI377030, AW438992, AW328677, AA112591, and AC005606. HLWBW29 2433 690515 1-375 15-389 H71264. HLWBT09 2434 887877 1-405 15-419 HLWBS62 2435 743406 1-627 15-641 AA214571, AI341246, AI686298, AI652114, W72303, AW391831, AW445137, AI672184, AI872269, AA805368, AA765438, AI865260, AI867970, AI364061, AA653004, AA283893, Z41015, AI652648, T82714, AW274161, AI964056, AC005203, and AC006111. HLWBR85 2436 784261 1-431 15-445 AI984203, W67492, AA883778, W67493, and AF086252. HLWBQ91 2437 790072 1-449 15-463 N91340, AF174590, AF199355, AF176699, and AL022395. HLWBJ65 2438 747784 1-526 15-540 AA424081, and AL049611. HLWBH92 2439 791355 1-443 15-457 AA457580, and R79039. HLWBG78 2440 888068 1-395 15-409 T89902, H30889, H22380, and H43169. HLWBF48 2441 721530 1-367 15-381 AI016222, R14088, AW189819, and Z73965. HLWBE74 2442 887967 1-336 15-350 HLWBC21 2443 869611 1-850 15-864 AI625008, W81042, AI161322, AI913667, AI284153, AA194209, AI654706, N51502, AA194051, AW205155, AI739408, AI380903, AA025476, AW392596, AW385770, AI240820, AW135136, AI697491, AW204701, AA680407, AA478609, AI916011, AI242934, AI497867, AA341635, AA025395, AA693802, AA521100, AI392857, and AC002400. HLWBA80 2444 720397 1-484 15-498 N41645, AW293280, AA287310, D86324, AF074480, AF074481, AB013814, Y15010, and D21826. HLWBA27 2445 931387 1-614 15-628 W88551, AW404842, AA292392, N41305, AA292935, N41626, AA491168, AA444087, H01356, R76165, AA001523, W45105, N28012, N42038, AA084557, AA296707, AW402649, AA069991, AA293237, AA428716, H80482, AA551614, AA297430, AA298686, AA128142, R75992, R77570, H68568, AA627682, AA405634, R89661, H28321, R78029, AI908992, N45084, H48883, AA298929, AA151090, AA055024, AA122427, AA296825, H91109, AA315750, R83924, AI218665, H72458, R08383, AA132173, AA027794, AA046903, AA077970, AA296925, W02601, AA297915, AA297486, AA297626, AI582212, AW170331, AA297026, H50802, N33748, AA297426, H24598, AA297282, AA296904, AA419378, AA296946, and AF070657. HLWAW86 2446 785395 1-522 15-536 AA460460, AA969196, and AA885014. HLWA509 2447 625419 1-223 15-237 AA602628, AA352444, AA363279, AC005969, AC004087, AL035414, AC006511, AL109627, AC004167, AL034430, AL133246, AC002543, L78833, AB022785, AC007055, AL049692, AP000032, AC005971, AP000065, AC005747, AC005726, and AL031311. HLWAR08 2448 959139 1-378 15-392 AA078617, AJ133128, and AF160798. HLWAO67 2449 751503 1-509 15-523 H82640. HLWAL31 2450 948928 1-110 15-124 HLWAJ18 2451 666281 1-634 15-648 H15126, AB006621, and AF043644. HLWAF02 2452 919714 1-1216 15-1230 AW003851, AW088297, AI004165, AW269624, AW073468, AA577265, W72446, AI863050, AI421770, AA421538, AI075847, AA700334, AA417216, AI240802, AI190446, AA780709, AA483528, AI569614, N94131, AA810760, R12682, W76345, AA814987, AI358895, AA872030, AA730737, N98502, AI690632, AI680891, R43271, N69310, R94006, W31068, AA864933, N58801, F10192, R16421, H99624, AI469697, AI017646, AI370275, AL036104, R93962, AA295338, AA357137, T52302, T52379, Z41369, F09802, H26767, AI370655, AA411262, AA318970, W74385, AI094731, AA411187, AF004539, AI344163, AI609867, AI308040, AI311256, AI271279, AI224267, AW384040, AW274178, AA741082, H26877, AW302337, AI284896, T65221, and R06090. HLWAE09 2453 789030 1-451 15-465 R20247, AI200505, AW004679, AA157883, AA314101, F36978, AA225574, AW305024, F31978, AW005776, AW337620, AW028286, AI022592, AI039214, AI797665, AW080293, N53067, AA131444, AA126253, AA724826, AA428376, AA418101, AW197423, AA865238, H10347, AA618216, AA069136, AA437116, C16904, F22050, AA147181, AA393974, AI970244, T11676, H56645, R58957, AA069174, N62528, AI908026, AW303992, AA069297, H15057, AA031896, AA552427, and AL050260. HLWAD57 2454 734655 1-450 15-464 AA213840, AI348503, AI680719, AA401344, AI868950, AI565065, AW058511, AI476408, AI298543, AI680824, AW207207, AA970373, AI084988, N74713, N22538, AL049651, AL133371, AL079352, Z83745, AC002416, AC006928, AL033539, and Z83848. HLWAD33 2455 702317 1-454 15-468 AI220952, R21518, AC004675, and AF088219. HLWAD32 2456 699158 1-289 15-303 HLWAD02 2457 919725 1-529 15-543 AI500547, and AW276592. HKZAH11 2458 965175 1-809 15-823 AI653262, AI637996, AI538731, AA808027, AL036361, AI536685, AI811344, AW087445, AA470491, AI499381, AI866090, AI608936, AI475371, AI270183, AI491852, AW088793, AI590415, AL079963, AW132056, AI284084, AI612913, AI537677, AW081036, AW102785, AL134259, AI818980, AW235482, AI802542, AL042745, AI635461, AL042382, AW051258, AI453322, AI271786, AW082113, AI637584, AI819976, AI698391, AI281773, AW150578, AI524671, AI926367, AI280637, AI559296, AI862139, AI491775, AI280747, AI890833, AI926790, AI564719, AI863241, AI932794, AI611738, AI955917, AI619502, AI677796, AW129659, AW026882, AW104724, AI610402, AI433 157, AI702073, AI978703, AI619607, AW192687, AI633125, AI922365, AL121365, AI570989, AI697321, AI521560, AI890223, AW080746, AI929108, AI620003, AI439762, AI269205, AI889376, AW081797, AI632408, AI499285, AI815855, AI648509, AI254731, AL119863, AI866457, AL036403, AW129916, AI872545, AI571909, AL045500, AI569583, AI798456, AI440448, AI624206, AI696612, AI922901, AI274508, AI934259, AI921248, AI570807, AI431975, AI783792, AW198090, N33175, AI799183, AI285735, AI287326, AI538085, AI567769, AI889189, AW071349, AI318280, AI636456, AI815232, AI536638, AW151485, AI452876, AW262565, AI634751, AI439256, AW075381, AI609331, AL042744, AI468872, AW104827, AI445025, AA225339, AI679174, AW074172, AL036780, AI355827, AI627988, AI648663, AW150453, AI670009, AI432969, AW118518, AW073865, AI174394, AA806720, AI871697, AL042628, AW074161, AI923370, AI281772, AI590227, AL039086, AL036901, AW020561, AL036736, AI816010, AI874261, AL036265, AI440239, AI285448, AI865931, AI538259, AI654276, AI269862, AI933589, AI491897, AW080090, AI625079, AL047763, AW148363, AI684234, AW192652, AI434468, AW160376, AL044207, AI873644, AI249800, AW190042, AI640873, AI445432, AI521040, AI499463, AI859511, AI630928, AI571439, AI631107, AI636588, AW080327, AI922676, AI567993, AI687728, AW088903, AW076093, AL043975, AI567128, AW162071, AI801460, AI591420, AI539771, AI500523, AI686817, AL048871, AI306613, AI247293, AL040241, AI537273, AW118496, AI819326, AW075667, AW166903, AI634737, AI539780, AI697137, AI591075, AW148408, AL045266, AI572021, AI682798, AI634345, AI818683, AI435641, AW117746, AI812015, AI610690, AI921379, AI537024, AW169671, AI801152, AI796743, AI476046, AI886753, AI687127, AI828682, AI610307, AI687362, AI620284, AI252023, AI918435, AW050850, AW193530, AI609589, AW073270, AI457369, AI286256, AI284517, AI431327, AI358107, AI538116, AI247193, AW166583, AI567940, AI923124, AI682971, AI469532, AF177401, I48979, I89947, I48978, AL133560, AL050277, AF113019, A65341, AF113694, AF111851, AL122050, AL122110, AL117435, AL137459, Z82022, A77033, A77035, AF090903, S68736, A08913, AL137557, AL137550, AL122121, A08916, AL137271, AF146568, AF090900, A08910, Y11587, AL110221, AF158248, E07108, AL117457, A58524, A58523, I89931, AL050149, AF090901, I49625, AF183393, AL122098, AL050393,AR011880, AF113677, AL133080, AL122093, AF125948, AF104032, AL110225, X82434, A08909, Y16645, I33392, AL117460, AL137463, X72889, AJ238278, U35846, AF113690, AL133640, AF078844, X63574, AF090934, AL049452, AF017437, AF090943, AF017152, AL133075, AF113691, AF106862, AF113013, AL049314, AL117583, AL133606, AF118094, AL080124, AF087943, AF113699, E02349, AL117585, AL050138, AL133565, AL122123, E03348, E07361, AF113689, AL049382, AL096744, Y11254, AJ000937, S78214, AL050146, AF091084, AL049430, AR059958, AL133016, AL049466, U80742, AL133113, AL049938, AL049283, AL133557, AL050116, U42766, AL110196, X84990, L31396, AL050105, AF090896, AF079765, L31397, AF118070, AL080159, AB019565, AL080060, AL049464, AF113676, AJ242859, AF125949, AF118064, AL133093, AL050024, AL137538, AL080137, AL117394, AL137527, AI2297, A93016, U00763, A03736, X65873, I03321, AL133072, AL049300, AF097996, AL137283, AL137521, U67958, AF026124, U91329, X96540, AL122049, A08912, X98834, U72620, X70685, AL080127, X93495, AF067728, AL137429, Z37987, AL137533, AL110197, AL137648, A93350, I26207, AJ012755, AF111849, AL122118, AF061943, AF111112, AF057300, AF057299, AF026816, AL050172, B08263, E08264, AL110280, I42402, AL137480, I09360, AF185576, E05822, I00734, AF119337, E00617, E00717, E00778, AL133077, A07647, E15569, AR013797, AR000496, AL137560, U39656, Y14314, AL133568, AR038854, AJ006417, AL137478, S61953, U49908, AF153205, I66342, AL133014, E02221, AR038969, AL080148, AF000145, AL133067, U96683, U68387, AF008439, Y09972, AL137476, AL137523, AL137292, AF081197, AL133104, AL137529, AR020905, AL137556, AF079763, AL137526, AL133665, Z72491, AL122111, AL117440, AF003737, AC006371, AF106827, U58996, I17767, AF067790, A08911, E04233, AL137294, A45787, AL137488, U78525, X87582, AL133098, AF162270, Y07905, AF081195, AF132676, AF061836, X81464, Y10655, AL080074, AF061981, AL023657, I09499, X62580, AF061573, M30514, L30117, AF139986, AF095901, and AE126247. HJMBX19 2459 668568 1-405 15-419 R32287, AA455162, AA456525, AA135649, and AI083959. HJMBS77 2460 772101 1-314 15-328 AW104918, and N62731. HJMBS10 2461 964464 1-595 15-609 T92671, AP000309, AP000048, and AP000116. HJMBQ90 2462 788834 1-543 15-557 AI912028, AW205965, AW204265, AA039572, and AA641146. HJMBN02 2463 919737 1-470 15-484 AA557385, and AC005214. HJMBI93 2464 929114 1-390 15-404 AI090083, AI829485, AW205724, AA772573, AA845116, AA074956, AA115510, AW190595, AA022952, AI141599, AA628482, AI051949, AW371164, AI097055, AI890975, AI337839, AA736989, AI081563, AI041864, AI393834, AI469272, AI342319, AW338241, AW264160, AI583596, AI354880, AI183444, AI936936, AL047697, AA700866, N94495, AA543017, N93380, AI493628, N32842, AA026953, N35378, AI198542, AI033873, AI034219, AI092332, AW079884, AI862812, AA830087, T15721, AI268105, N48023, AI280189, AI766704, W79295, AA771789, AA693396, AW081435, AI923501, AA789217, AI690543, AA704989, N69040, AA192860, AI758815, R39361, R97800, AI820003, AI378456, AI672120, D62879, F05041, AI904662, AI266086, AI914468, AA699763, AI907483, AA788953, AA923476, N79464, AA888029, AI355472, W81453, AI634896, T41193, AA649798, AA649807, R01135, AA862997, AI302880, Z39546, N69916, AA343461, AI221819, AI266004, AA939287, D62955, AA526695, T32169, H23424, AW152231, AI829263, D79898, N40473, AI040552, AI933545, AA484853, AA913558, H00652, AW409609, T24050, AW002183, AW020740, D79437, AA992887, AA682612, AA888356, R38439, H05312, T31408, T31832, F03611, AA026821, T40331, AI220939, AA501526, T40800, AA987725, AA643534, AA894839, T31460, AI458807, T31396, T24820, N66339, T34745, AA114833, AA676395, W79282, AW384647, AW384682, AW384661, AW384674, AW384672, AW384666, AW384683, AI129830, AW196003, R46594, AI815016, AA055008, AI094056, H00741, AI926449, AI472549, AA193064, N91240, D79446, AA856615, AI538772, AI114447, AL110153, and AF113701. HJMAV93 2465 828110 1-431 15-445 AI828559, N33343, AA512946, AW242837, AA776686, AA908183, AW402709, AA761704, AI088906, AA035207, AA045460, AI418843, AI362157, AW183346, R05828, AA627883, AA026236, C20746, and AA349140. HJMAU07 2466 961623 1-488 15-502 AI631661, AI656482, AI655799, AW168207, AI745171, AI739521, AW073890, AW161625, AW157477, AW157176, AW002703, AW090343, AA738238, AI906428, AW293743, AW328076, AW328075, AA249074, AI991472, AI653282, AI652717, AI654896, AW393827, AW393832, AI203310, AW390900, AA776677, AW390889, AA381902, AW364462, N93494, AW160794, AW163150, AW161159, AI802780, AA974383, AB016089, AF201422, AB016092, AC004493, AB016088, and AF161338. HJMAQ86 2467 785410 1-544 15-558 AA082617, AA082622, T49308, and U73643. HJMAQ14 2468 657579 1-465 15-479 R25621, C04010, and C03959. HJMAJ91 2469 811222 1-439 15-453 H96543, AA043831, AW250847, AI741631, AI741642, T72311, AI761422, AI992202, AI143894, AA194496, AA635765, AI992194, AA983373, AI890651, AI341988, AA336193, AI081852, C02956, T84215, D79135, AI050718, AA424281, AA348739, AA194697, AA029252, W51957, AI475478, AA370818, AA349624, N80191, AA216646, AI805451, AA907523, AI248525, AA565574, W48641, AA609560, AI077909, AA378570, AA112530, AW408361, AA161054, AI709345, AI497917, AI074107, AA150947, W38482, AA279104, AA654134, AI131385, H08872, AL138451, W07568, and C03234. HJMAI62 2470 742612 1-343 15-357 AI927723, AA430100, AI749184, AA493808, AI755214, AI754567, AI061313, AI797998, AI355246, AI299442, AI754105, AI090334, AI336771, AA659923, AA904275, AI732458, AA127499, AA630854, AA669238, AW172727, AL048060, AI821881, AI821918, AI049845, AL046519, AW272815, AI791457, AI732501, AA526415, D44672, AI859438, AI283938, AW167154, AL079553, AW238495, AW439703, AA297208, AA714110, AI076236, R83585, AW008184, N42508, AA468322, AI801563, AA577755, AA480486, AW410983, N38991, AA593537, AI598003, AW021608, AI686703, AW407632, AA535216, R94909, AW002831, AA470496, AI078409, AI274691, AW167799, AW151247, AA297666, AA469230, AA309156, AA600202, AI049643, AI620992, AI862716, AI884404, AC002325, AC001644, AC005233, AC005768, AL121603, AC004999, AC005484, AC005031, AC005682, AC005697, U95739, AP000501, AC004878, AC006312, AF111168, AL121653, AL021391, AC004910, Z99716, AL132712, Z94721, AP000355, AC005619, AL050318, AC004033, AC005565, AF196779, AP000248, AL121748, AC004253, L44140, AC005261, AD000671, AF165926, AL121782, AC002400, M89651, AC005391, AL035405, AC005924, AC005703, AP000030, AL031733, AC004099, AL031255, M37468, AC004771, AC004020, AC005632, AL035659, AC005759, AL117337, AF064861, AL121658, Z68756, AC002126, AC004859, AC006953, Z93023, AL031311, AC007868, AL121580, AL031432, AL035071, AL109952, AC002477, AL022316, AC005037, AC005074, AL008582, U80017, AF001548, Z93930, Z68322, AF205588, AL022336, AL035422, AF003529, AC004228, AF023268, AC005215, AC005180, AC005231, AC002991, AC005725, U52112, AC007055, AC002350, AC005081, AC003663, AC007766, AC008044, AF134726, AC003982, AC007421, AC007686, AD000812, AC006241, AJ236701, AC006449, AL117355, AC006441, AC005696, AC004686, AC004148, AF039906, AC007637, Z86090, AC003043, Z94865, AL022315, AP000301, AC004805, AL035697, AC004150, AC002558, AC005972, AC005695, AC008009, AP000503, AC016027, AC006515, AL031662, AC006468, AC000025, AC006261, AC005914, AC005933, AC006285, AL021877, U78027, AC004659, AC006530, U92032, Z84489, AL035423, Z84466, AC005331, AL022165, AF165088, AC005516, AC005800, AP000251, AC007666, AC007225, AD000092, Y10196, AC005192, AC004491, AL049569, AL109623, AF187320, L78810, AP000359, AC002470, AC004983, AP000252, AC006480, AC006139, AC005911, AC005193, AL031680, AC005899, AL020997, AC007308, AL031575, AC006211, AL096791, AC000353, AC006013, AC005520, AP000350, AP000065, AC002985, AL021453, AL008718, AL035698, AC007227, AC005527, AL031602, AC005529, AL096817, AL049631, AC016830, AL050308, AC005736, AC007546, AF042091, AL034420, AC004895, AC004643, U85195, AC005618, AL022318, AL021154, AC000134, AC005534, AL009181, AC006370, AL049576, AC007298, AC004922, AP000008, AC004950, AC010077, AL022721, AF024534, AL137191, AC005837, AP001055, AL031584, AC006317, AC005102, AC005089, AL031985, U91326, AC002316, AC005325, Z83844, AC002306, AC007066, AL096701, AE000658, AL022476, AL135744, AL049780, AL133448, AC002565, AC005701, and AC004963. HETLF29 2471 909762 1-404 15-418 AA960957, AI001155, and AC004664. HETJY68 2472 752542 1-598 15-612 AW002051, AI634267, AI243174, AA436186, AA436311, AI431959, AI061116, AA761592, H06947, N23373, AA086090, and AA947734. HETID12 2473 655199 1-497 15-511 AA054591, and AJ090055. HETHO01 2474 921649 1-420 15-434 H73781, H73794, and AA250749. HETHB18 2475 529467 1-233 15-247 HETFF68 2476 529587 1-193 15-207 HETFF43 2477 529589 1-190 15-204 AC002430, and AC007384. HETDU61 2478 742157 1-407 15-421 R09668, W27308, AI017666, and T40006. HETDA25 2479 677490 1-323 15-337 T75438, and AC005041. HETCO27 2480 533536 1-101 15-115 AC004525. HETCH01 2481 961038 1-577 15-591 T63959, AI903998, AI903827, AI903970, AA846926, AI903969, and T25149. HETBM55 2482 929285 1-419 15-433 W58542, W58508, AA338107, AL110415, Z21137, AA677723, AB033071, and AL049742. HETBE61 2483 965638 1-690 15-704 AA044700, AI217938, AA621573, AI341648, AI888183, AA448474, AI378270, AI377879, AA761808, AA908986, AI554608, AI499447, AA405744, AI658858, N94970, AA826528, AA845274, AA337749, AW104676, AA514257, AA450024, AA446662, N99058, AI200828, AI638236, AA749175, AA907567, AI860350, N30595, AI015967, W56551, R42965, T72602, AA496049, AI240555, AI628397, AA992373, F09967, AI680576, AI970903, AF120324, AF120323, and AF151833. HETA591 2484 790499 1-699 15-713 N40393, N27230, AI001868, W03460, AA336991, AA293193, AA456181, AA352669, AA404703, AA404253, AA455873, and AB029039. HETAS81 2485 778539 1-272 15-286 AA195574. HETAS62 2486 754155 1-475 15-489 N94153, AA337208, and AL021368. HETAJ14 2487 660831 1-744 15-758 W73113, W73134, AA336749, and H71426. HEQCC01 2488 924849 1-991 15-1005 AI984000, AW269830, AI801497, AI376738, W44650, AI951239, AI299070, W44651, AI277888, AI090780, AI460194, AA913912, AA889345, AI469976, AI277222, AI470014, AI302046, AI352112, W70230, H57665, AW385653, W70229, AI206087, Z24798, AJ141926, W61319, H58505, AW129398, AI393721, W65404, AA092527, AW385674, AA853182, AA527482, AI147785, AA229903, AI916555, AI832158, AB037938, and AC004477. HEQBT78 2489 773528 1-239 15-253 AA088215, HEQBP18 2490 855578 1-451 15-465 AC005412, AP000212, AP000134, AC005081, AC002302, AC005015, AB003151, Z97055, Z85987, AC005899, AL035415, AC005088, AP000688, Z99128, AL139054, AL079295, AC004953, AC002094, AF196969, AF001549, AC006480, AC005914, Z81369, AC004966, AC005480, AF045555, AC004491, AC002544, AC006530, AC005011, AC004659, AP000553, AC003109, AC004815, U91323, AC006449, AF196971, AL034379, AP000689, AF064861, AC005225, AF030453, and AL050307. HEQBI09 2491 739877 1-241 15-255 AI682994, AI860517, R59606, AW128847, AA427939, AW089100, AA688398, AA678726, AA865152, AI301869, AI537473, AI635629, AA206817, AI635651, AI635668, AI589266, AA382581, N30811, W26239, AA522648, W51988, AA083277, AR068569, and E02783. HEQBG85 2492 827915 1-262 15-276 AA242840, D31085, AA375146, AA329739, AA359153, AA375223, AA461165, AA852329, AA113413, AA461339, AI375044, D86983, and AF200348. HEQBG60 2493 427813 1-366 15-380 C16876, AA194321, AA433852, C17161, AA180946, AI525618, AI557711, AA074286, C17197, C17260, AI061627, AI114766, AA632855, AL036120, AI110700, AI110702, AI733732, A1110877, AI133691, AA247674, AA469023, AA469454, AI557407, AA468291, AA469339, AA533497, C18679, AI791942, AW277101, C18086, AI525833, AA457778, AI557430, AI525740, AI525655, AI114723, AL037233, C17850, AI525594, AI110881, AI114736, AI557512, AI133606, AI557620, AA190509, AA099765, AI525675, C17646, AA496319, AI065146, AI110734, AI114585, C18308, AI133681, AA225972, AA211183, AA193158, C17276, AI133444, AI525609, AA149719, AA210993, AA193139, AI133323, AI111183, AA192142, AA650320, AL036950, AA985072, AA147287, AA263129, C17869, AA111992, AA730713, AI525223, AI525224, AI174851, AI133348, AI525704, C17777, AA213805, AA259235, AA214706, AA1 12937, AA187242, AI002878, AA095540, AI524915, AI525208, AI525308, AW270677, AA610217, AA096071, AA179575, AA226053, AA093633, AA192769, A1110870, AI525584, AA677781, AA092031, C18932, AA714096, AA211267, AA193022, AA193077, AA186774, AI557196, AA713554, AI541088, AA090151, AA090965, AA196107, AA180127, AA090969, AA088526, AA090214, AA085797, AA094071, AI678834, AA104032, AA096116, AI750078, AA083602, AA090907, AA579547, AA573649, AI557051, AI064914, AA177026, AA091026, AA093711, AA082180, C17762, D51282, AA090990, AA179142, AA090166, AA090807, AA130057, AA090943, AA197087, AA196431, AA187784, AI833114, AA195842, AI207615, AI720161, AA115803, AA180940, AI002718, AI557661, AA757623, AI133486, AA095787, AA603485, AA618243, AI147501, AA215934, AA090757, AA093442, AA659381, AI114764, AA249267, C18118, AA090144, AA092908, C17330, AA837217, AI459413, AI721213, C17357, AI114553, C18846, AA929066, AA094655, W56031, AI721239, AI114569, AA091885, AI720842, C17253, AA216092, AA089796, AA640485, AA196942, AI366461, AA091799, AA464911, AI832465, AA249171, AA091648, AI174902, AI525114, AI133302, AA094383, AA736456, AI557580, AA214119, AA467951, AA216196, AA176675, AA090764, AA071205, R28885, AA093449, AA653037, AA487737, AI985682, AA515626, AA131159, AA213941, AL047782, AA192982, C02686, AA559143, AI833042, AI114776, AA652805, AA985256, AA090427, AA641024, AA091970, AA090288, AI541480, AA092535, AA197267, L08441, I27367, X93334, X54629, J01415, X62996, V00662, D38112, AF134583, U35430, X93347, D38113, X93335, D38116, D38114, AB005535, and A70826. HEQBE78 2494 772860 1-399 15-413 HBQBE71 2495 760305 1-439 15-453 AC006254. HEQAZ01 2496 916321 1-448 15-462 T89326. HEQAM59 2497 739220 1-146 15-160 W20223, and AW300240. HEQAK94 2498 793250 1-286 15-300 AI884723, AI971997, AW136547, AW168144, AI582351, AW028249, H11116, R36152, AI982536, R71232, AI926458, and AC004126. HEQAF54 2499 729594 1-451 15-465 R53056, and H08598. HEQAD73 2500 914044 1-579 15-593 AW291088, AA037761, AI937151, AA148558, AI207722, AA143058, AW242313, AA039270, AA150219, AW248839, AW134681, AA782955, AW044454, AI720406, AA159625, AI824032, AI359017, N44915, AW247279, AA136239, AW249260, AA136326, AA736535, AA312218, AA159616, AA165673, N33099, AI677832, AI869047, AI867484, AA159698, AW247893, AA934072, AA143176, D60324, R29152, AI590805, AW169153, N57511, AI393129, AI080402, H83533, N34512, AF161487, AF161527, AC007565, and AC007229. HEQAA93 2501 792255 1-546 15-560 W92197, AJ272825, AA016235, W94926, AI243425, AW082258, AW297127, AI241137, AI424820, AA813649, and AI289258. HEPCB04 2502 941270 1-512 15-526 AI917109, AW003912, AI080595, AA235033, AA235201, AW450977, AI969306, AA193652, AA193549, AI928801, R22829, T69554, AA588382, N94214, N80329, R17380, AL023581, AF153605, and AF151861, HEPB092 2503 952996 1-427 15-441 W80428, AI281960, W58699, AA417821, AI191334, AA524259, AI140335, AI272028, AI198251, AI279567, AI077948, W58105, AA976989, AI279283, AA568684, N75444, AI768190, AA471035, AI042070, H27894, R69416, AI207043, AI093933, AA931805, AA057072, AA776787, AI356687, N89605, AI830795, H20193, AI125808, AI125797, AI160353, AI394538, AI336185, AI858974, AI352347, AI268758, AI298093, AI298398, AI268851, AI191106, AA976789, AI184456, AW000778, AA479904, AA976567, AI184383, N80954, AA328860, AA482453, AI338345, AI042254, N68172, N80657, AI813413, N68196, AI343021, AA705334, AA931904, AA532627, AA721003, AA715390, W69319, AW327781, AI301403, W58698, W58215, N68260, AA481706, W05193, N54740, AI086220, AA159198, AI369601, AI074994, AI184042, AW439353, W69215, AW149380, H03721, H19993, H83921, H02830, AA428492, AW071418, N80631, R98136, H83779, R69545, AI800014, AA603925, H20384, H72739, T35392, AI026120, H50256, AI370680, AI554686, AA356398, AA765315, AW150959, AW008524, AA513681, AA481467, and R48307. HEPB085 2504 783362 1-679 15-693 AI090010, AA779356, R70094, AI088640, R79670, R28363, R39498, and AF121177. HEPAY26 2505 825778 1-180 15-194 AI678727, AI373871, AA335883, R47985, AI915014, and AA586390. HEPAX40 2506 535627 1-726 15-740 AI888322, AA149051, AA149050, AI051764, AI985657, AI862905, AI082688, AI559607, AW151020, AI275490, AI824512, AI240781, AW294730, AI370307, AI925301, AI491857, H28424, H39903, D62631, AI956009, and AL137566. HEPAX16 2507 667665 1-473 15-487 AI216316, N95121, AA524146, AA826400, AI572953, AA576084, AA243582, AA693835, AA648272, AA830864, AA872868, AI083498, AI278286, R64633, AI919073, F25383, AJ624649, AI380699, AW027102, R64632, AA975873, AA971324, and AL035416. HEPAQ35 2508 707533 1-520 15-534 T86787, N47173, AA335769, AA406114, AI560856, AA410382 and AA774453. HEPAP34 2509 703336 1-669 15-683 AA458879, AW138005, AA406623, AI749863, AI299810, AI968830, AI084067, AI749131, AA335721, AI473485, AA976661, AA464428, AA411695, AW130055, C03960, AI880337, AI904562, AA864979, AA781665, AI198298, AA430699, AI275029, AA706499, AW206841, C01121, and AI695779. HEPAN05 2510 932893 1-477 15-491 AI218711, AI918047, AI918977, AI288674, AI085618, AI139776, F29008, AA335421, AI929165, F35667, AC004751, and AC004646. HEPAK04 2511 933039 1-477 15-491 AI004158, AA335529, AA847893, AI262232, AW292700, AI950883, AA808598, AW183055, AA505961, AA478576, AA255751, AI468599, AI417159, AI678423, AW043579, AI333775, AI521274, AA009947, AI379044, AI089360, AI027938, AW173026, N49409, AA417796, AA173415, R94723, AI972464, W31503, H63962, AI703182, AW193647, AI741193, AA456887, AA470626, AA885985, D30922, and AC006557. HEPAJ14 2512 657440 1-231 15-245 H26683, and AA335271. HEPAJ04 2513 933091 1-353 15-367 AI219496, AI187819, AW085963, AA335263, AA669515, AC007993, and AC002094. HEPAE58 2514 509130 1-348 15-362 R46509, AA335475, AA335926, and Z63111. HEPAE02 2515 921389 1-211 15-225 AA484651, AA335440, and AC004887. HEGBC03 2516 922550 1-290 15-304 AI445299, AW005649, AJ470184, AB032959, and AL021393. HEGBB67 2517 751233 1-340 15-354 AW295266, AI765278, AI261553, AI367242, AI050799, AI433693, AI672068, AI308137, AI769877, AW003759, AI201838, H18343, AI761277, AI823875, R85423, H18100, AI760769, AI984928, AW149699, H20325, R84272, AA860751, AI369859, AI262936, AI474901, AA013231, AA013325, and H18141. HEGBA01 2518 915596 1-425 15-439 T51466, and AC006333. HEGAX04 2519 927260 1-522 15-536 AA236038. HEGAQ91 2520 789940 1-261 15-275 H54234, AL037663, W84821, AJ012221, AJ007014, and AL031319. HEGAL55 2521 731654 1-423 15-437 AI962879, AA133284, AI863307, AI679213, AA768727, AA417760, AI083774, H95609, AI538225, AW409962, AA516124, AA417846, AW196578, AW074110, AI168476, AI825102, and AI885413. HEGAJ08 2522 959216 1-557 15-571 AA059456, AA040649, R60003, AA058951, AI970861, AA662962, AW268083, and AA045527. HEGAC02 2523 918992 1-519 15-533 AA813370, and Z93016. HEEAY84 2524 782706 1-370 15-384 N77524. HEBAX09 2525 912065 1-400 15-414 AW305246, AA405462, and AA336099. HEEAW40 2526 710655 1-385 15-399 AA176878, AA984649, and AB009973. HEEAP59 2527 738892 1-401 15-415 AA083887. HEEAM25 2528 677599 1-771 15-785 AA086139, AI088145, AW131790, AI857700, AI283095, AI813629, AJ917113, AI478664, AI919281, AI967944, AI499083, AI655215, AW136596, AI767765, AI825582, W16832, AA831238, AI381212, AW028578, Z19309, AA912593, AI497888, H86248, AA019370, and AF061261. HEEAH94 2529 794257 1-332 15-346 AI832117, and T60136. HEEAH76 2530 769950 1-503 15-517 T90469. HEEAH57 2531 734488 1-475 15-489 AA158378. HEEAH16 2532 661827 1-598 15-612 W94212. HEEAG51 2533 930810 1-430 15-444 T51329, R55106, AW298352, U73637, AF015416, and AF083108. HEEAG12 2534 724929 1-546 15-560 AA577763, AA633422, AL037129, AA400644, AI814562, AI951746, AA160713, AW273309, AI760380, AI829095, AI830606, AW410028, AA069839, AI762794, AA740152, AI079211, AI831826, AI436417, AA715294, AW248582, AI479090, AI446523, AI564707, AI580739, AI718353, A1114856, AI031714, AI979218, AW020139, AI927726, AI625558, AI803385, N63450, AI499665, AA609811, AL041488, AI559675, AA808909, AI805112, AA721567, AI356504, AW131446, AI371162, AI608666, AA621666, AW117835, N47802, AW303837, AI635165, AI792502, AI792459, AI681955, AI356534, AI741024, AA461161, AI371783, AW167885, AW269461, AA186776, AI961876, AI569468, AI983819, AI198692, AI677976, AI580884, AI285382, AI627469, W69718, AI684007, N26300, AI285371, R74106, AA070631, AW082099, AI187296, AI122688, AI619582, AI923356, AI053500, AA465244, AI568377, AI475683, AA569404, AW131064, N62435, AI378096, AI114801, AI361711, AI538412, AI053809, AW102909, AI284485, AA609804, AA157510, AA983155, AA719436, N69868, AI581694, AA813458, AI025704, AW068095, AA730994, N49709, AI254995, AA772777, AI272877, AI025243, N68207, AA074131, W29008, AI241762, AA069789, N49747, AW001954, AI635898, AW167269, AI821623, N24969, AI565122, AA679739, AW295592, AI708945, AA426103, AI129305, H81268, T57228, AA454089, AA173256, AA570192, AW167442, H88671, AI888551, AW130022, AA218723, AA490126, AA160557, AA629812, AW316580, T48377, W07841, AW238570, AA402187, N64337, AI401141, AA582071, AA582069, N71249, W28998, AA878904, AI537917, AA398896, AA393126, AA158019, AW028732, W81377, AW117980, AI587486, AA385065, N67689, AI686807, AI969514, AA070932, R69118, N55579, AI951358, AA501522, AI690866, R82294, R69237, AI866191, AA069566, AA807712, W95312, AI539138, AW151663, R49753, AA557272, F27924, AI200767, AW073563, W94577, AA861022, AI074168, AA490869, AI682865, AA719453, H89972, H16003, AA972251, AA888800, AA311106, AA479531, AA158667, AA725811, AA365495, AI751587, AI624034, AA015906, AA569951, T74260, H93995, AA716314, AA452503, AA863083, AA506968, H02178, AA429696, AA427565, AA720992, H43481, F26439, AA828474, T55982, AA504793, R27973, AW193086, AI001209, AA630055, AI791854, AI886874, AI752142, AA255883, AI359741, AA340175, AA031466, AA427714, N79151, R46819, H53048, D11678, AW014403, T55334, AA485288, AW316811, AA429565, AA832289, AA398182, F27649, H88719, AA015746, AA046017, AI289762, H86474, R85355, W78088, R68012, AA485423, F22385, N49815, H60678, X07417, AJ238283, AB026899, AP000352, Z75889, AP000500, AL031057, AL031430, AC005192, AL118497, AP000345, AL021394, AC006077, Z69705, AC005013, AC007372, AC005681, AC004754, AC004757, AL049837, AL109938, AC005667, AL024507, AF186194, AF020802, Z75746, AC005881, AC005530, AC002544, AC007666, AC006132, AB023056, AF165926, AC007999, L09706, AC000378, AC000052, AC005206, AL031671, Z83843, AP000555, AJ004799, AC002487, AL031391, AC006344, AC004019, AF019413, AC006539, AP000502, Z11740, AL109847, AP000514, AL049839, AB014080, AC004067, AP000520, AF117829, AP000687, AC005204, AC006039, AC004558, AJ229041, AL022721, AC007066, AC002295, AC006441, AC004206, AL096773, Z83826, Z83841, AC004887, AC005962, AL034394, Z94054, AC005694, AC004860, AC004167, AC003991, U91326, AC007687, AC006952, AL023875, AJ011930, AL117356, Z82976, AP000354, AL050321, Z98742, AC006222, Y18000, AC020663, AC003663, AC005570, AC008981, AL034421, AC002525, AC004448, AC004858, Z83844, AB023048, AL035407, AL022101, AP000511, AL133246, AL031685, AC006251, AL023575, AF109076, AC005006, AL135745, AJ003147, AF165147, AF109907, AC006008, AF050154, AC005529, AL133243, AC006427, AL049653, AL035458, AC004520, AL096703, AC005034, AC004021, AC006198, AC006236, AC005531, AL022332, AC006992, AC004922, AL035073, AC009731, Z98304, AL021877, AL079342, AF129077, AC007546, AC007860, AC004912, AC006449, AL035455, AC002299, AL121756, AL121653, AC006557, U92032, Z84489, AF053356, AC005510, AC004655, AL035681, AP000432, AC006121, AC004813, AL020995, AC005324, AF111169, AL031650, AC008282, AC005913, AC006011, AC005829, AL031594, AL022401, AL049776, AL133312, AC016027, AC004213, AL021918, AP000350, AP000457, AC005343, AL022400, AC007225, AC005668, AC002375, AC007172, Z93403, AL133245, Z93017, AL034402, AL035608, Z84487, AC005874, AF134471, AL022723, Z95889, AL136504, AF107885, AL133297, AL109758, AC000353, AC005828, AC004474, AL031602, AF134726, Z69710, AL121577, Z73900, AC007560, AL021938, AC006120, AC006026, AC008101, AC007376, AL021154, AF011889, AC002531, AB000879, AC005971, AB000882, AC002402, AC002455, L34079, AL020997, AC007387, AL137191, AC000134, AL135879, AL121790, Z95437, AL034430, AC005320, Z82203, AC005684, AP000506, Z82215, AC015853, AL008583, AC004973, AC004158, AC005832, AC005060, AC002996, AC016830, AL133304, AC003102, AC002536, AC009241, AF052041, AC006313, AL049539, AC007283, Z82196, AC005567, AC007298, AJ010395, AC004762, AL049757, and AL021397. HEEAD13 2535 470886 1-182 15-196 N44039. HEEAB40 2536 710668 1-414 15-428 R08794, AI470646, AA506458, AA303007, AI002941, AI933534, AI691091, AI903462, AW380254, AA011026, AW021735, AW275510, AA493695, AA321168, AA455670, AW089101, AI311927, AA131035, AI933658, AA019312, AA635739, AW338179, AA676971, AI460009, AW004884, AA788982, AA188676, AI633390, AL045739, AI584186, AA679154, AI431240, AI469968, AA179944, AI888752, AI005388, AI872020, AI927741, AA834707, AA223174, AA358515, AA527209, AL042225, AA847515, F25733, AW193461, AA600869, AW022897, AA101689, AI268334, AI268336, AW276827, AL120343, AL046205, AA572713, AA584612, AI687343, AI249573, AI696595, R07234, AW023865, AW168618, AW270343, R68223, AW265009, C75026, AA467820, AI611569, AI611598, AL043009, AL045053, AA468244, AW020340, AI133164, AI345157, AI521632, AI246409, AA570385, AL037042, AW075998, AW193265, AA420998, AI350211, AW340844, AA421078, AI860020, AI953275, AA613345, AA279421, AI619997, AL119713, AW302903, AA720702, AW402237, AI149478, AI860013, AI962874, AI017251, AI110595, AA568494, AW102846, AW439562, AI754653, AI199137, AI110688, AI754658, AW104030, AA355083, F27407, N49368, AA580808, T77680, AA789192, AW169038, AA338904, AI271126, AA747070, AI500453, AW273218, AA662478, AW167374, AW178018, AW177870, AW131155, AA494089, AL038705, AA833896, AA833875, AA584167, AA577906, AI311684, T40308, AI932599, AI133297, AI744995, AI251082, AI631317, AI309643, N27584, AA837600, AW050726, AA468022, AW438643, AA834792, AI085719, AA480792, AA838190, AA640410, AA640430, AA357991, AC003070, AL034428, AL122020, Z93096, AC005660, AC009411, AC002426, AC006568, U82828, AC003009, Z85996, AP000350, AC005005, AL049843, AC004687, AP000556, AP000557, AP000552, AC009516, AL034429, Z71183, AL023879, AL121825, AC004016, AP000351, AC005800, AC005753, AP000352, AC005155, AC006336, AC006350, AL080241, AL035587, AC005833, AC006236, AC007686, AC005771, AC005899, AL049760, AL022316, AP000553, AC003691, X55922, AC007114, AC004233, AL031228, Z85987, AF001552, AC007546, U91318, AL110292, AF001550, AP001056, AC000088, AC000071, AC005703, AL136295, AF002997, M87917, U04355, AC005512, Z84718, U18181, AC007225, AC004893, AL079295, AC007036, AC005071, AC005736, AC007536, AL008716, AC005091, AC005007, AF109907, AC008042, AF001298, AC004173, AC004397, AP000304, AC004192, AP000047, AC005233, AC006962, AL133382, AF003626, AC004975, AP000115, AP000504, AL008721, AL034420, L78833, AL022101, AL031767, Z84466, AC000025, AC004837, AC005519, AC005844, AC005527, AL132716, AL009172, AC005088, AC006017, AC004945, AC006120, AC003035, AF129756, AL031054, AC005539, AL109628, Z95114, AC007308, AC005529, AL035541, AC007263, AC004491, AC002368, AC005781, Z99755, AC005412, X87344, AC006254, AL031294, AL031055, AC005988, AC004525, AC002303, AL031730, AL031733, AF024533, AC005821, AL133404, AC007993, U91321, X98745, AP001045, Y07848, AC000026, AL034554, AC002059, U85195, AE000658, AC005738, AL031447, AC010206, AC006125, AC004081, M87926, AL031286, AF043945, AF064866, AC006007, AC004984, AC008012, AL133448, AL031075, AC003689, M17623, X66401, AL031295, AC004818, AC005209, AF001549, AC005479, U69639, AC007774, AL137682, U61238, U60970, U61224, U57833, AF184614, Z99754, AC007162, AC004652, AC005212, AC004242, AC004883, AL031667, AC003101, AC003046, AL109653, AL022331, AC004066, AC006942, AL133163, AC005906, U95090, AC006055, AC012384, AC006991, AP000240, AL079300, AC008545, AC004816, AL110164, AL096805, AL031276, AC003658, U78027, L81648, M87921, Z68285, AF030880, AF172277, AC005740, AB014078, AB004907, AB023052, AC004750, U73635, AC003690, U75931, Z81450, AP000302, AC005525, AC006127, AC006138, AF037338, AC005202, AC004755, AC005624, AC005568, Z69733, AC002499, Z70688, AF050154, AC007565, AC006277, Z93024, AC005777, AC004643, AL049856, AC004209, Z70051, AC006139, AL080242, AC004696, AL121934, and AC002037. HEAAX26 2537 684734 1-264 15-278 H97463. HBAAU20 2538 911255 1-443 15-457 H91826, and Z97989. HEAAR47 2539 973284 1-444 15-458 AC004672. HEAAR21 2540 883939 1-522 15-536 AW295831, AI369420, AW298562, AW151269, and AC005146. HEAAN43 2541 842032 1-323 15-337 R97645. HEAAM71 2542 950736 1-612 15-626 T87255, AA078363, and AC008039. HEAAL76 2543 770200 1-425 15-439 AA169155, and AI741303. HEAAG84 2544 896892 1-591 15-605 HEAAG42 2545 714041 1-1098 15-1112 AA044749, AA135685, AA135713, AA156933, AA099390, AA099389, R67663, AA135671, R66064, R24427, AA044673, AA043522, and AA043523. HBAAB66 2546 844361 1-804 15-818 AI340603, AL037454, AI358042, AI308035, AI678409, AW268060, AI345347, AA806719, AW302973, AW089275, AI445069, AA088789, AI561356, AA464646, AI656270, AI906328, AI582966, AI571511, AA417129, AI581139, AI537677, AI568060, AW059828, AI623941, AI951062, AI950973, AL038778, AI365256, AI242248, AI434731, AI281687, AW059713, F36859, AI621341, AI539153, AI345131, AI472536, AI473451, AW148970, AI207454, AI446373, AW193467, AL118781, AW078805, AW082532, AA911767, AI678446, AI336575, AW090279, AI868163, AI537643, AL041115, AW084097, AI284509, AI570257, AI267185, AA070889, AI348901, AI636197, AL047042, AW021717, AI624304, AL037582, AW150826, AL037602, AI570966, AI469505, AI697324, AI280607, AL039086, AI699011, AI446823, A1114703, AI345253, AI589428, AI345677, AI349933, AI859464, AI886594, AW021091, AI917963, AI628325, AI800464, AI468970, AA493923, AL040241, AI687568, AI050666, AI866469, AW085786, AW172975, AW020419, AI799674, AI312210, AI452876, AI491710, AI801556, AI963040, AI345745, AI366922, AW302924, AI400725, AL036638, AI560679, AI873638, AI634919, AI633321, AI565172, AI623736, AI554487, AI915295, AW088560, AI583578, AI684021, AW169671, AI539800, AL048351, AI470293, AI885989, AI567582, AA587590, AI472566, AI916419, AW163834, AI866608, AW082600, AA916133, AI933992, AI671669, AL039276, AA830396, AI521560, AW051088, AI671651, AW161202, AI309306, AI610357, AI439020, AL048323, AW151136, AW044029, AI886415, AW411235, AI421091, AI683559, AI251221, AA853213, AL048340, AI269205, AI499915, AI263331, AI446124, AI345688, AI366875, AI360560, AA019328, AI590702, AI291973, AW080214, AA853539, AA127565, AW191844, AI310332, AA807088, AL036954, AW076127, AI866082, AW411351, AA099519, AI401697, AI811422, AI559863, AL042382, AI865320, AW409775, AW088899, F34866, H89138, AW403717, AW190725, AI696969, AW058233, AI270099, AL047387, AI648663, AI679622, AW268261, AW082623, AW020095, AI923989, AW151850, AI419650, AW131112, AI249877, AW150326, AW132107, AI524654, F33262, N63128, AW081383, AI874151, AL038575, W60514, AI801325, AI333104, AL036772, AI929108, AI539771, AI554343, AI620093, AI537837, AI334445, AW410609, AI612721, AL046463, AI573026, AL047344, AI270295, AA908294, AI095113, AW089006, AW088944, AI624529, AI805688, AI306562, AI521108, AI611743, N25081, AI289791, AI349957, AW083804, AW168503, AI520765, AA830821, AI590423, AI479577, AI912531, AI888621, AI336634, AI696626, AI357599, AA292158, AA848053, AA761557, AI589993, AW149876, AW079334, AI310940, AI866465, AI345005, AC002404, AL133104, AL110196, I33392, AI8777, I41145, AL137480, I48978, AF113019, U77594, AF118094, AL133072, Y11587, S77771, AL080154, AF000145, I89947, AL080159, I17544, AF044323, AR038854, Y10080, L30117, A08913, AF162270, A08910, A08911, A08909, A76337, A08916, A08912, AF036941, A57389, A08907, AF067420, A08908, AR029490, I42402, AL133016, A45787, AL133014, AL133619, U49908, U67958, AL133081, AF030513, S76508, I89931, I89934, I49625, AL117416, AF079765, AF061573, AL137478, AF159615, X84990, E06743, AF117657, AL137547, U80742, AL137294, AL049324, AL137556, L19437, Y10823, U92068, AF107847, AF061795, AF151685, AL050138, AJ006417, U72620, AL122123, AF111112, A21103, Y16645, X87582, E05822, AL122106, AL117460, AR034821, E02221, AI8788, D55641, AF095901, AC002467, AF012536, AF137367, AL137292, AL137258, AL049465, AF026816, AL049464, AF028823, AF022813, I48979, X63162, AF183393, AF205861, AL137256, X66975, AI2297, D83989, AL110171, AF113689, AF126247, AL049339, AL137557, X79812, AF215669, AF118070, AL137574, AL117578, AL133075, I66342, AF015958, S68736, AF185576, AL117435, AL137555, M92439, U51587, AL110218, AR068753, AR068751, AF207750, AF132676, AF061836, E01314, AL023657, AL137660, AL137705, X53587, AL080060, AF003737, Y11254, AF065135, A76335, AL137538, X55446, I92592, U96683, AF090900, AL050108, I68732, A93016, I89944, AF119337, AF091084, E15582, L13297, AL137530, AF094480, AF185614, Z37987, Y14314, AF113676, AF016271, X72387, X93495, AL137548, AR053103, AL137463, X82434, 536676, AF067728, AL049460, AL137640, AF118090, AF115392, AF118092, AL080110, AL137536, AL110221, AL050149, AF199027, AJ003118, AF158248, AF061981, AL137488, AL080148, AF139986, AL117629, AL137550, E01614, E13364, AL080163, Z97214, AF016047, AL122045, AL133560, AL133558, AL133640, AL117626, E12806, AF200464, AF151109, AL122098, AL122100, A07647, I09499, AL117440, AF146568, AF180525, AL080137, U72621, AF008439, AL137476, AF113691, AC007298, Y10655, AL137627, Y16258, AF114170, Y16257, E02756, Y16256, AL137526, A07588, E04233, L40363, AL133645, AF113699, X80340, AR038969, AF210052, E01812, AL133624, AF026124, AF047716, M96857, AF039138, AF039137, A27171, AF081571, U78525, AL110224, AL122121, AF057300, AF057299, AF182215, X83508, AL137300, AF179633, AF169154, AL080086, AL137429, X66862, I09360, and AL133093. HCORB05 2547 928679 1-426 15-440 AI343543, AA580865, AA932494, AA581041, AL119399, AL042544, AL042382, AL119457, AL079794, AL043168, AL043152, AI345347, AL119511, AI698391, AI624293, AI627988, AI890907, AW161156, AI002285, AW130930, AI868931, AI682798, AI866770, AI884318, AW051088, AI886753, AI572096, AI270429, AI473536, AI624120, AW130534, AI889189, AI918449, AI620284, AI538850, AI587121, AI491775, AI702073, AL079963, AL037454, AI570807, AW163834, AI538055, AI499890, AL120853, AI824576, AI433157, AI916419, AI241923, AL039086, AL119863, AI270183, AL043355, AI633125, AL037582, AL037602, AI538564, AI915291, AW152182, AI580436, AI670009, AI918435, AL038445, AI445992, AI923989, AW169604, AA806720, AW021717, AI627893, AI863382, AL037649, AI866469, AI493567, AI917252, AW080746, AI500061, AW192687, AI866083, AI961589, AA641818, AI686906, AI567582, AI267162, AI799183, AI671642, AI919500, AI567769, AI582932, AL079741, AI521560, R32821, AI950729, AI963846, AW167083, AI954183, AI612913, AW050850, AL121014, AI802542, AW238688, AI623941, AL036274, W74529, AI890507, AI207656, AI969655, AW129659, AI446373, AW131294, AI579901, AL036638, AW129230, AI919534, AL041734, AW151136, AI445990, AI926878, AI631095, AI872423, AI635016, AL036673, AI932794, AI536738, AI434741, AI874261, AI285448, AW193911, N29277, AI766348, AI452560, AW020397, AI889376, AI648509, AI572021, AW161579, AI866040, AL041772, AI280607, AW022699, AI859991, AI537261, AI623179, AI799408, AI254226, AI630252, AI923370, AA579618, AI869125, AI440239, AL038605, AI434468, AW162194, AI345416, AI802240, AI345612, AI270706, AW051258, AL045500, AW079409, AI288305, AI554821, AL134259, AI690748, AL046595, AW303152, AW026882, AW020419, AI609069, AI522052, AI345415, AA740450, AI889372, AL048496, AW149925, AI571439, AI860003, AI800155, AI963458, AI345778, AA420722, AW089275, AI874166, AI702068, AI284517, AI702406, AW243886, AA127565, AL046200, AI284484, AI801152, AI288285, AW083374, AI612750, AW192652, AL119324, AI698427, AI540674, AA502794, N33175, AI685517, AI559619, AW020693, AI471282, AI954504, AI884528, AI499963, AW149026, AI580198, AI493576, AW198090, AW118518, AI917963, AI345745, AI538764, AI500588, AI866465, AI284131, AW090071, AW160916, AI651840, AI815232, AW168452, AI281762, AW006032, AI866457, AI630928, AI590630, AI242248, AI439452, AI590830, AA908294, AI863191, AI355779, AI628331, AW090736, AI499986, AW102864, AI354630, AI619502, AL040241, AI951950, AL036802, AI768496, AL121365, AI870192, AI866090, AI536574, AI287233, AI635067, U77594, Y11587, I89947, AF139986, I48978, I33392, Z82022, AF158248, U35846, AF090900, A08910, A08909, AR013797, AR038854, A77033, A77035, AF111849, AF177401, AF126247, AL122100, AL133560, AL080148, AF113677, AF183393, AL133075, AF030513, A08916, A08913, AF090943, E06743, AL050277, AF079763, AL137479, AR020905, AF087943, AL096744, I09499, AF111851, AL133067, X84990, A08908, AL050092, I48979, AF090934, AF067728, E05822, AL133080, AL137271, M27260, AF090903, Y09972, Y10080, AL137533, AL133113, AL050138, AL137480, AL133558, Y10936, AL137294, X52128, AL133557, AL117435, A65341, X70685, AF069506, AF106657, AL133072, A08912, I89931, A93350, AF061795, AL050149, AF151685, AL137557, I49625, Y07905, AL133565, AL137292, AF078844, AJ000937, E02349, AL137550, AF061981, AL122093, U42766, Y16645, AL080159, Y14314, E15569, AL050393, AL117583, AB007812, S78214, U88966, AF067790, X87582, AL117460, AL133016, X83508, AF091084, AF118070, AL049430, AL049382, AL133640, AL050116, A45787, A03736, AL110280, X82434, AL049314, AF153205, AF026816, X81464, AF097996, AL049283, AL110196, I46765, Z37987, AF185576, U78525, AL137488, AF106862, A21103, L19437, AL049452, AL110221, AL023657, AJ012755, AB019565, AF017152, AF000301, X72889, AL137529, AL117457, D16301, X57961, AL133665, AL133568, AL122121, AF061943, E12747, A15345, AF111112, AL122110, AL050024, AI8777, A08907, AL122050, AL117416, AL137521, AF008439, A08915, A58524, A58523, AL137539, AF113019, AF118094, AL049938, AF113699, AL122106, AF090901, AR034821, AF061573, AF113690, S36676, AL137560, AL049466, A76335, X80340, AL080234, AL117394, L04504, AL080163, AF081197, AF113691, AL050366, D83032, I00734, AL137463, AF119337, AF113694, AF100931, AF017437, AL137283, AF132676, Z72491, AF106827, AF061836, U58996, AL137459, AL080158, AF026124, AF090886, E00617, E00717, E00778, AL050146, AL050108, U80742, AI2297, E02221, AF079765, AF032666, AF057300, AF057299, X98834, U72620, AR011880, AL137537, AC002467, S76508, I89934, X06146, AL137478, X92070, AL110225, AF146568, AJ005690, AL049465, X96540, AL110218, AL080074, AL137640, I03321, AL137538, AF039138, AF039137, AL122118, AL050155, AF081195, AF028823, M86826, AL117649, E07108, AF162270, A07647, AF125948, I66342, X93495, E01614, E13364, AL137476, AL080124, A08911, AL049300, X79812, Y11254, I42402, and AL133098. HCOPM06 2548 933473 1-616 15-630 AI494320, AI289626, AA349607, and AC004230. HCOPI07 2549 951645 1-399 15-413 AA683346, AI991127, and AW385510. HCOPF07 2550 951655 1-476 15-490 AI027619, AA926665, AA954546, AA398085, AA621275, AA634531, and AA724256. HCOOF07 2551 951693 1-504 15-518 AI160370, AA993156, and AW269609. HCONP02 2552 917577 1-332 15-346 AA226397, H29285, Z39193, and D61466, HCONM33 2553 971637 1-463 15-477 AI339840, N40932, AW044507, AI216527, AI620878, AW316937, AI292180, AI358083, AI954691, AW006263, AA321122, AA321123, AI654341, N46790, AI953114, N69895, AI970523, AA226346, AA226347, and AF196969. HCOMM05 2554 925952 1-1647 15-1661 AI681802, AA534542, AL044632, AI912061, AI912050, AI271683, AA587766, AA143726, AA565889, AI298280, AA079779, AI983603, AI052230, AI369272, AI148467, AI028441, N93876, AI950520, AW024410, AW138648, AI933105, AI244430, AA436795, AA583571, AA079751, AA595313, AA158795, AI373637, AA947417, R27340, AW182724, AW381284, AI869920, AI348932, AI244362, AI335320, AI305978, AI991003, AI250467, AI335365, AI611516, AI252717, AW086414, AI252210, AI310178, AI252203, AI345138, AI308005, AI310659, AI250541, AI311180, AI250964, AW301779, AI348928, AW086115, AI250009, AI311179, AI345868, AI305732, AI311504, AW303046, AI269522, AI254155, AI335130, AW301495, AI251162, AI862506, AI371584, AI311043, AI251045, AI590436, AI284537, AI310038, AW301422, AI224292, AI252538, AI053635, AA158794, AI862262, AW268255, D31472, AI685886, AW371409, AI540612, AW071370, W40369, AI886550, AW371414, AI955911, AI024888, AA143739, AI254135, AI246935, AW177721, T35070, C00345, AW371416, AA902858, AW369434, AA581215, AW117919, AI932915, AI554245, AW132056, AI800433, N80094, AI358213, AW088899, AI539153, AI919107, AI680457, AI802833, AW020095, AA946741, AI698401, AL110306, AW118398, AI251830, AL041772, AI805769, AI929108, AI468872, AI680280, AI251205, AI888621, AL046356, AW195957, AW002342, AI889953, AI659795, AI520809, AI569309, AW151785, AI498579, AI478123, AL119791, AI922901, AW198075, AW088134, AI432736, AI610645, AI587606, AI699011, AI476109, AI697324, AI335214, AW081255, AI868831, AW073994, AI888944, AW189415, AI280670, AI590686, AI783861, AL119863, AI866608, AI886124, AI345746, AI680498, AI628217, AI802240, AL040241, AI687065, AI469738, AI805688, AI249877, AI345677, AI952920, AI431909, AI633062, AW406745, AI343059, AI376180, AW168031, AI682743, AI349933, AI689175, AI345608, AW084219, AW103886, AI933785, AI633419, AI922577, AW071417, AI554218, AA225339, AI866002, AI433976, AI800138, AI828731, AW079159, AW191844, AI619716, AI696626, AI824576, AI612759, AW089179, AW151729, AI696819, AI867042, AI566630, AI689571, AI280661, AI636619, AI955866, AI537617, AI919345, AI800453, AI812015, AW105620, AI961310, AI963216, AI590120, AI494201, AW082594, AI627880, AI308032, AI282326, AI866770, AI400725, AI345471, AI366549, AW148716, AI636719, AI648684, AI344785, AI249962, AI866741, AI868931, AL043326, AW020693, AI801322, AW088903, AW151714, AI364788, AW085681, AW129230, AI611743, AI471361, AW083804, AI493559, AI628833, AI696533, AI589993, AI365256, AW151136, AI539771, AW059837, AL137526, I48978, AL050138, AL080127, AF078844, A65341, AL122098, I42402, A08916, I48979, AL080060, I89947, AF026816, X84990, A08913, I89931, AF158248, A08910, I49625, AE061943, A08909, AF017152, AL049382, AL050277, AF125949, AF104032, AL137538, S68736, AL080074, AF177401, AL133014, AL122121, AF162270, S78214, AL122093, AL133606, AF003737, AF113689, U67958, AR059958, A45787, AL117440, AF111112, AL137556, E03348, AR000496, U39656, U96683, AL133560, AR038969, Y11587, AL137271, AL133093, AL050146, AL080137, A08912, Y16645, AL137527, AF081197, AL110196, I33392, AL117394, X93495, AL137463, AB019565, I26207, AR038854, AL137478, AL133640, AL133081, L30117, AF113691, AF008439, U72620, AL133104, AF097996, X87582, E05822, AL050024, A77033, A77035, X70685, AL049314, X92070, AL110221, AL133016, X96540, AL133565, X72889, AF113019, I09360, AL117460, Z37987, AL133075, Y14314, AL050149, AL133077, A58524, A58523, A93016,AR013797, AF111849, AL117585, AF026124, AL137521, AF081195, AR011880, AJ242859, Y09972, AF113676, AF090896, E02221, AF079765, E04233, S61953, AF091084, AF100931, AF183393, E07108, A07647, AL080124, AL137476, AF119337, AF113690, AF067728, X63574, U00763, X53587, AL049466, AF090934, AL122049, AF118064, AF118070, AL122050, AL080159, AL133098, AL133557, AF113013, AL096744, AL133568, AF146568, U80742, AL133113, AF106862, AF057300, AF057299, AL137557, AI2297, AL050393, X82434, AL137459, Z82022, AL050108, AF185576, U78525, AJ006417, AL122110, AL133067, I03321, AL049300, AF090943, AL049283, AF113699, E15569, AL117457, AL049464, X65873, A03736, AF067790, AL049452, A90832, X62580, AL133645, AL137550, AL050116, I00734, AF090901, U35846, AF111851, AF113694, AF017437, AF113677, L19437, AF118094, Y11254, AJ000937, AL133080, AE087943, AL049430, AL137560, AF132676, Z72491, E02349, AF061836, M30514, U58996, AL122111, AF210052, AL117583, AL137648, AF079763, AF153205, AJ238278, A93350, AF090900, AF090903, E08631, AF125948, L31396, AL137533, E00617, E00717, E00778, U68387, AL110225, Y07905, AL117435, AL133072, U42766, AL117432, L31397, AL137480, U91329, AJ012755, AL110280, X98834, AL122123, E08263, E08264, E07361, AL137300, I41145, AL137294, AL050172, AL137273, AL080086, AL133665, AL122118, AL137292, AC002467, AL137283, A18777, AL137705, AL049938, AL110197, AL117649, E06743, AF051325, AF061795, AI284538, and AI335140. HCHQA48 2555 908495 1-558 15-572 R71963, and AF201303. HCHOX63 2556 957690 1-942 15-956 W52941, H61325, AW024501, AA594317, AW182848, H55390, Z83838, and Z93244. HCHNW48 2557 862478 1-312 15-326 AA778950. HCHMX82 2558 850340 1-566 15-580 W85822, AI379248, AA935747, W85821, and AF111167. HCHMW18 2559 966985 1-524 15-538 W30916, N99978, AI660617, AA307815, AW166174, AA877685, AI692837, F07221, AI123170, AI906507, AW390249, AA078788, and AB017614. HCHMJ89 2560 786765 1-300 15-314 T79918. HCHMI96 2561 800129 1-567 15-581 U91323. HCHMI15 2562 935298 1-946 15-960 AI202736, AL134545, AW298000, AA126125, R54251, H12916, AI497978, AW296905 T35758, AI347137, AA190916, Z42146, AI989727, R96064, AL050318, AB023181, and U67140. HCHCI07 2563 952957 1-486 15-500 AA777369, AA700323, AI243088, AW292657, AW292654, and AL031666. HCHCH68 2564 869084 1-488 15-502 AA494453, T75265, R51391, T78355, AA368764, R61709, AA101560, R35616, and Z25135, HCHCG28 2565 686431 1-590 15-604 T77459, AA052981, T89679, AI138597, AW104281, AW050704, AA053474, T78622, AA677771, AW207204, AI049552, AA005222, AA515524, H07942, C01507, and AI367213. HCHCE78 2566 773428 1-226 15-240 AI142134, AL038838, AL037436, AL038822, AL037295, AL038983, AL040617, AL044186, AL041238, AL047012, AL044037, AL047170, AL040463, AL040576, AL041752, AL045684, AL038532, AL040625, AL037727, AL047219, AL044162, AL040839, AL043677, AL040193, AL043467, AL040510, AL040621, AL043538, AL047183, AL043496, AL040464, AL046442, AL041133, AL041324, AL037435, AL043492, AL040322, AL041602, AL041098, AL044125, AL041347, AL041096, AL041635, AL045753, AL043923, AL043814, AL040294, AL043845, AL038761, AL044074, AL044064, AL041955, AL041459, AL041577, AL041730, AL040052, AL041523, AL043627, AL040472, AL041374, AL046850, AL040768, AL043848, AL040444, AL042135, AL043570, AL046994, AL046914, AL039316, AL046392, AL045671, AL041246, AL049018, AL045990, AL039643, AL037341, AL037343, AL037335, AL045857, AL079852, AL037443, AL037323, AL037279, AL039432, AL042096, AL042898, AL038745, AL039360, AL134524, AL043941, AL045817, AI547295, AI547006, AL040075, AL045328, AL041163, AI541506, AL041296, AI526186, AL040119, AI547039, AL044272, AL046327, AL041086, AL044258, AL040149, AL041168, AI526194, AL044199, AL041159, AL041344, AL047057, AL045920, AL040148, AL041358, AL044201, AL040458, AL044187, AI526073, AL041233, AI546855, AL041292, AL041346, AL040571, AL041142, AL040332, AL044529, AL039338, AL040529, AL079878, AL041197, AL046330, AL040745, AL040370, AL044274, AL040128, AI525320, AL047036, AL045989, AL047163, AL040342, AL040553, AL041186, C16305, AA585476, AL040414, AL041277, AL039744, AI526187, AL134110, AL040285, AL040155, AL040091, AL044165, AL043440, R28735, AL041131, AL040090, AL041051, AL040168, AL043775, AI526176, AL041278, R29177, AI557084, AL040253, AI546891, AL041227, AL040082, AL043444, AL040329, AL046150, AL041140, AL045327, AI525306, AL040255, AI541345, AL040385, AL040238, AI541535, AI535660, AI535639, AI546899, AI546921, AL040263, AI541356, AI526184, AI557262, AL045725, AL038651, D61254, D29033, AL043612, AL039915, AL049069, AL043537, AL046147, AL041210, AL080031, T23957, AI557787, AI557864, AL046097, AI557279, AJ239433, AI525321, T23888, Z28355, AI541510, AI557727, T23985, AI541527, Z30131, AI541365, AI557148, AI541013, AI525203, AI540967, AI557807, AL048677, AI541374, AI525556, R29218, AI547250, AL045211, AI525431, C15189, AI557734, AI546945, AI541514, AI546999, AL046099, AA585439, AI541509, AI541307, AI547291, AI541523, D57186, AA585101, AL045994, AL045340, I08396, AR064707, AR038762, I08389, AR035975, AR035977, U94592, AJ230935, Y09813, I19525, X81969, AJ230902, I66487, E13740, AR009151, D13509, Y16359, I66485, AJ238010, A91750, I15718, I08395, I15717, AR066494, M28262, AJ230951, AR031566, A85395, A85476, E03627, AJ244003, AJ244004, I48927, AJ244005, A90655, I03331, 100682, X83865, A02712, E12615, A02710, AR035193, A92133, A84772, A98767, A20699, E14304, A77094, A77095, AI1624, A11623, E00609, A07700, E00696, AI3392, AI3393, I62368, AR031488, I13521, E00697, A84776, A81878, A84773, A84775, I52048, A93963, A93964, A27396, AR062872, I63120, AR017907, A84774, AR043601, A95117, A95051, AI8053, AR027100, I49890, AR062873, I44531, AI1178, E01007, I28266, AR067731, AI8050, AR037157, AR054109, A23334, A75888, I70384, A60212, A60209, A60210, A64973, AR067732, A60111, A60211, A23633, I21869, AR007512, I13349, B03813, A25909, AI0361, A86792, A58522, A91965, A24783, I44516, A24782, A70040, I66482, I60241, I60242, I66483, I66484, E16678, AF082186, A82653, I66498, I66497, I66496, AR038066, A58524, AR027099, I66486, E16636, A58523, A93016, AR051652, D78345, I18895, AR035974, AR035976, AR035978, I44681, I84553, I84554, A11245, AR062871, I06859, AR051651, AR038855, AF149828, I18302, AJ231009, E12584, D17247, A35536, A35537, A02135, A02136, A04663, A04664, I01995, A20702, I25027, A43189, A43188, A20700, I26929, I44515, I26928, A98420, A98423, I26930, I26927, A98432, A98436, A98417, A98427, I08051, D50010, AR008429, I05558, AJ230867, AJ244007, A22734, A93923, A22738, A93916, A24548, Z32836, A24546, AR051957, E17098, AJ231028, I05845, AB025273, D13316, AJ230972, A93931, AJ230845, A70872, AR063812, AI6035, Y14219, S60422, I66495, I66494, A22739, A06631, I33632, AR009152, I03669, E03654, I66481, I03668, A83642, A83643, A68112, A68104, I15353, I66488, I66489, I66490, I66491, I66492, I66493, AR054723, A05993, A05975, A05973, A05991, A83151, A05995, AR023813, and AJ230996. HCHBQ27 2567 682308 1-232 15-246 AI142134, AL037436, AL038838, AL038983, AL037295, AL037435, AL037727, AL038532, AL038822, AL037323, AL037443, AL040617, AL044186, AL041238, AL047012, AL040294, AL041635, AL044037, AL045817, AL047170, AL040463, AL040576, AL045753, AL041752, AL045684, AL040625, AL047219, AL044162, AL043923, AL043814, AL044074, AL041602, AL043492, AL040839, AL043677, AL040193, AL043467, AL040510, AL037343, AL043845, AL037335, AL040621, AL043538, AL047183, AL043496, AL040464, AL046442, AL040472, AL044064, AL041730, AL041523, AL041133, AL043627, AL041459, AL041577, AL041324, AL040052, AL040322, AL040444, AL040149, AL041374, AL041098, AL046850, AL040768, AL046994, AL040119, AL041955, AL043848, AL046914, AL043570, AL042135, AL041096, AL044125, AL045920, AL040075, AL041163, AL044272, AL039316, AL047057, AL041347, AL046392, AL045671, AL040458, AL041159, AL038761, AL044199, AL041292, AL041358, AL041168, AL044187, AL044258, AL041296, AL040148, AL040332, AL045990, AL041142, AL041346, AL041086, AL049018, AL040529, AL040370, AL040745, AL046330, AL041197, AL046327, AL040128, AL047036, AL041233, AL040342, AL040571, AL040553, AL041246, AL039338, AL044274, AL040285, AL079878, AL041277, AL042096, AL044165, AL040091, AL040155, AL039360, AL041186, AL041131, AL039744, AL037341, AL045989, AL040414, AL039432, AL041051, AL040168, AL044201, AL040090, AL043775, AL039643, AL041278, AL079852, AL040253, AL041227, AL045857, AL043941, AL041140, AL040255, AL040238, AL134524, AL040082, AL040329, AL043444, AL040263, AL045725, AL039915, AL037279, AL043612, AL042898, AL041210, AL044529, AL049069, AA585101, T23957, AL045328, AA585476, T23985, AL038745, I11028, AL043537, AL045211, AL046147, AI525556, AI525431, AI541374, Z28355, Z30131, AI541365, AI540967, T23888, AI541514, AL080031, AA585439, R28735, AL047037, AI547039, D61254, AI546999, AI541523, AI541535, R29445, R29177, AI525306, AI547295, T41289, AI557731, AI546945, AI546891, AI526194, AI526073, AI541508, AI546855, AI557262, AI557787, AI525316, AA174170, AI541017, AI541534, AI557799, AI541509, AI546828, AI535639, AI557807, AA585453, AI541390, AI536138, AI525328, C16300, AI556967, AI541307, C15189, AI525320, AI526140, AI541013, AI526184, AL041344, AI557238, AI541510, C16305, AI546875, AL043440, AI526187, R29218, AA585356, AJ239433, AI546899, AI557796, AL047163, D57491, AI557802, AL134110, AI525321, AL046097, AI541345, D55233, C14723, AL036259, AL040385, AI526196, AI526176, AL046360, AR064707, Y16359, E13740, D78345, I18895, A60212, A60209, A60210, A60211, M28262, AJ244003, AJ244004, AJ244005, I08396, E03627, I48927, A98767, A93963, A93964, AR062872, 163120, AR017907, AR062873, A25909, AF082186, AI8050, A23334, A75888, I70384, A60111, A23633, AR007512, I15717, A91750, I15718, A81878, A90655, A02712, A77094, A77095, A95051, AI8053, A64973, AR031566, AR062871, I84553, I84554, I06859, I00682, AI1623, AI1624, E00609, AI1178, E01007, I13349, AI0361, I08395, AR043601, A20702, A43189, A43188, A20700, A98420, A98423, A98432, A98436, A98417, A98427, A35536, A35537, A85395, A85476, A02135, A02136, A04663, A04664, AR038855, A11245, X83865, A84772, A84776, A84773, A84775, A84774, AR067731, AR037157, AR054109, AR067732, A86792, A58522, I03331, A02710, E12615, AR035193, A92133, E14304, A07700, AI3392, AI3393, I62368, AR031488, I13521, I52048, A27396, AR027100, I49890, I44531, I28266, I21869, A91965, I44516, A70040, E16678, A82653, E16636, A93016, AR038762, I44681, A24783, A24782, A95117, A58524, A58523, AF149828, I05558, X07299, I01995, I25027, I26929, I44515, I26928, I26930, I26927, I08051, I60241, I60242, A20699, E00696, E00697, E03813, I66482, AR009151, I66485, I66483, I66484, I66498, I66497, I66496, AR038066, AR027099, I66487, I66486, AJ230935, AR051652, D50010, AJ244007, AR051651, U94592, AJ230902, X81969, AR008429, A22738, I08389, D13316, AJ230951, Y09813, AJ231009, AJ230972, E12584, I19525, AB025273, AR051957, AR035975, AR035977, D13509, Z32836, I18302, AJ238010, AJ231028, A70872, E17098, I66495, I66494, AR035974, AR035976, AR035978, AR066494, A70869, A22734, AR022273, D17247, AJ230867, AJ230845, I36244, AR051864, AJ231011, AR051865, A06631, S60422, A93923, AR063812, A24548, A24546, Y14219, A93916, I05845, A93931, AJ230996, AI6035, I03669, I03668, AR009152, I33632, 166481, A83642, A83643, A68112, A68104, I15353, I66488, I66489, I66490, I66491, I66492, I66493, A83151, E03654, A05993, A05975, A05973, A05991, A05995, AR054723, AR023813, and A22739. HCHBN09 2568 625420 1-296 15-310 AA490421, AL042558, AA143483, AI751943, AA570806, AA484359, AA559183, AA653913, AA630887, AA523435, AA501772, AA559952, AA527935, AA524677, AA225694, AA210775, AA503945, AW238516, AW068638, AA602214, AA573681, AA713862, AA244217, AA715930, AA507086, AA225790, AA808984, AA226111, AA484441, AA215536, AA569543, AA177022, AW205065, AA721566, AA579157, AA504410, AA484585, AA507346, AA501732, AA469188, AA572887, AA420582, AA484413, AA559222, AA483267, AA503561, AA503559, AA501776, AA226527, AA244238, AA244062, AA593223, AA558141, AA507083, AA508631, AA484393, AW262396, AA501676, AW270415, AW276908, AA507504, AA501686, AA243995, AA128300, AA226184, AA578473, AA614211, AA640515, AA480385, AI546955, AA640374, AA640660, AA525062, AA558384, AA558321, AW238171, AA533287, AA513603, AI547126, AA484407, AA484411, AI752801, AA744305, AA578301, AA484493, AA501860, AA469324, AA225576, AA558562, AA650456, AA226721, AA507340, AA580043, AA565166, AA177069, AA654282, AA507851, AI751343, AA501702, AA470558, AA501768, AA420704, AA213708, AI547141, AA469320, AI541035, AA470511, AA126213, AA229564, AA156629, AA418713, AL047173, AA420674, AA484506, AA715538, AA715539, AA558552, AA177158, AA578705, AA484528, AA095495, AA641115, AA577936, AA228389, AA578934, AA226065, AA484825, AA492033, AA557861, AA225908, AA593222, AA554099, AA572721, AA229733, AA524632, AA092036, AA728878, AA280059, AA244235, AA484371, AA420581, AA503581, AA484351, AA469430, AA715953, AA484473, AA640279, AA506724, AA484355, AA569626, AA558635, AA572695, AI541320, AA244291, AI750492, AA229680, AA632980, AA744014, AA484503, AA744402, AA503572, AA492436, AA603249, AA484501, AA501628, AA632877, AA484598, AW068441, AA228318, AA516524, AA745386, AA082424, AA721565, AA484497, AA552890, AA559234, AA248574, AA568529, AA507529, AA578038, AA578046, AA225681, AA513550, AA703294, AA904212, AA578286, AA216366, AA721557, AA558278, AI908775, AA501743, AW404859, AA572940, AA480386, AA569729, AA578235, AA565138, AA244176, AA650405, AA420814, AA420781, AA228769, AA832132, AA225824, T25993, AW238161, AA504185, AA742807, AA650193, AI751960, AA984344, AA742817, AA910156, AI570436, AA090304, AA713894, AA911380, AA230090, AA557473, AW134801, AA418450, AA535657, AA524782, AA640849, AA501719, AW138762, AA148775, AW270207, AA910120, AA558842, AA713729, AA715509, AI752091, AA602216, W65429, AA630940, AA484920, AA650621, AA744273, AA659512, AA904299, AA713887, AA508052, AA558282, AA568519, AA910096, AW419149, AA715931, AA552891, AA640998, X00525, V01270, AF061800, X82564, M11167, U34341, X59733, X59734, U13369, U34339, U34336, U34342, U34338, U34337, AF061798, AF061799, U34340, AF061797, X02995, E08821, AF173998, AF152142, AF152161, AF152150, AF152151, AF152152, AF152155, AF152156, AF152157, AF152159, AF152160, AF152162, AF152164, AF152165, AF152166, AF152167, AR016103, AF152144, AF152158, AF152922, AF152145, AF152153, AF152154, AF152168, AF152149, AF152163, AF152148, AF152143, AJ270045, A85621, AJ270046, AF152146, AF152147, A85520, A86292, AC005626, and AL136329. HCHBM26 2569 681404 1-140 15-154 AI142134, AL038838, AL037343, AL038983, AL037436, AL037335, AL037323, AI547295, AL037443, AL037727, AL038532, AL134524, AL044125, AL038822, AL040193, AL037435, AL044162, AL041347, AL047012, AL040621, AL043538, AL043496, AL043923, AL043814, AL041238, AL044186, AL040617, AL041324, AL043845, AL040463, AL047170, AL038761, AL044037, AL041635, AL040294, AL044064, AL041459, AL041577, AL047219, AL040464, AL040625, AL040576, AL045684, AL041752, AL045753, AL037295, AL046850, AL040768, AL041098, AL046994, AL046914, AL040052, AL040510, AL043467, AL040444, AL043677, AL040839, AL047183, AL043492, AL041602, AL041246, AL044074, AL041730, AL041523, AL043627, AL041374, AL043848, AL043570, AL040472, AL042135, AL046442, AL040075, AL041133, AL045671, AL045817, AL041955, AL040322, AL039316, AL045328, AL041296, AL041096, AL046392, AL040119, AL039360, AL041163, AL044272, AL041086, AL044258, AL042096, AL040149, AL041168, AL044199, AL041159, AL047057, AL045920, AL040148, AL049018, AL041358, AL038745, AL040458, AL044187, AL041233, AL039643, AL041292, AL041346, AL045990, AL040571, AL041142, AL040332, AL042898, AL037341, AL039338, AL040529, AL079878, AL041197, AL046330, AL040745, AL040370, AL044274, AL040128, AL047163, AL043941, AL134110, AL047036, AL040342, AL040553, AL041186, AL040414, AL041277, AL039744, AL044201, AL040285, AL045989, AL040155, AL040091, AL044165, AL046327, AL041131, AL040090, AL041051, AL040168, AL079852, AL043775, AL041278, AL039432, AL040253, AL045327, AL041227, AL037279, AL040082, AL043444, AL045857, AL040329, AL040255, AL040238, AL041140, AL038651, AL040263, D29033, AL045725, AL039915, AL043612, AL048677, AI547291, AL041210, AL044529, AI318479, AL041344, AL049069, R29218, AA585325, R28895, AA283326, T10982, R28967, AL038878, R28965, AA174170, R28892, R29262, T11028, R45895, R28735, R29445, AL038024, AL048714, R29177, AA585476, R29172, AL045211, AL047340, AA585101, D61254, Z28355, AI546875, AI557734, AI526176, AI557864, AI541356, AI525306, AI557262, T18597, AL043537, D57491, C16300, T23957, T23985, D59436, R29179, AI526184, AI541508, AI525500, AI525431, AI541523, AI547006, AI546999, AI525556, AI547250, Z32822, D55233, C14723, AL048657, AI541374, AA585439, C16293, D53472, C16305, AI557787, AI526194, AI541514, AI546945, AI540967, AI541390, AI557763, AI541205, AA585329, T41289, AI557731, AI541365, C15737, D57186, AI541533, AI557740, AI557727, AI541535, AR064707, AJ238010, AR066494, D17247, A93923, D50010, D13509, E13740, A93916, Y16359, AR062872, AR062873, A91750, A84772, Z32836, A84776, A84773, A84775, A84774, I05558, A93931, A60212, A60209, A60210, A60211, I19525, X83865, AJ244003, AJ244004, AJ244005, X81969, A98767, A20702, A93963, A93964, I63120, AR062871, AR017907, A43189, A43188, A20700, A25909, A98420, A98423, A98432, A98436, A98417, A98427, AF082186, D78345, E03627, I48927, A35536, A35537, A02135, A04663, A02136, A04664, I84553, I84554, E17098, I06859, AI8050, A23334, A75888, I70384, A60111, A23633, AR007512, A81878, AB025273, AR038855, A90655, D13316, A02712, A77094, A77095, A95051, AI8053, A64973, I08389, AR031566, I00682, A11245, AI1623, AI1624, E00609, AI1178, E01007, I13349, AI0361, AI6035, I05845, AR043601, I08396, A85395, A70872, A85476, I44681, AR067731, AR037157, AR054109, AR067732, A86792, A58522, AR063812, M28262, AF149828, Y14219, I33632, I03331, S60422, I01995, A22738, A02710, E12615, AR035193, A92133, E14304, A07700, AI3392, AI3393, I62368, AR031488, I13521, I52048, A27396, I25027, AR027100, I49890, I44531, I28266, I21869, I26929, I44515, I26928, I26930, I26927, A91965, I44516, A70040, E16678, A82653, I08051, E16636, I15718, A93016, I15717, A22734, A24783, A24782, A95117, AR035975, AR035974, AR035977, AR035976, AR035978, A58524, A58523, AJ231028, AJ230935, AJ230972, E03654, A06631, AR054723, AJ244007, I08395, AR023813, I66495, I66494, I60241, I60242, I66498, I66497, I66496, I66486, I66487, AJ230902, AJ230845, AJ231009, A05993, A05991, AJ230867, AJ230951, A22739, and AJ230996. HCHAI62 2570 743411 1-135 15-149 AL134524, AL045327, AL045328, AL047163, AL042898, AL134110, AL038838, AL037343, AI547295, AL037295, AL038983, AI142134, AL037436, AL037335, AL037323, AL037727, AL037443, AL038532, AL038878, AL044125, AL047037, AL037435, AL038822, AL041347, AL040193, AL043923, AL043814, AL047012, AL041238, AL044162, AL044186, AL040617, AL043845, AL038761, AL043496, AL040463, AL047170, AL044037, AL041635, AL040294, AL044064, AL041459, AL041577, AL047219, AL040576, AL040625, AL045684, AL043538, AL041752, AL040621, AL045753, AL046850, AL040768, AL046994, AL046914, AL040052, AL040444, AL040464, AL040510, AL043467, AL043677, AL040839, AL043492, AL041602, AL044074, AL041730, AL041523, AL043627, AL041374, AL047183, AL043848, AL043570, AL040472, AL042135, AL041324, AL046442, AL041133, AL045671, AL041098, AL039643, AL041955, AL045817, AL039316, AL040322, AL040075, AL046392, AL039360, AL040119, AL038651, AL041096, AL044272, AL041246, U46344, AL044258, AL042096, AL041168, AL041163, AL044199, D29033, AL041159, AL045920, AL040148, AL047057, AL040149, AL041296, AL049018, AL040458, AL044187, AL041358, AL041086, AL038745, AL041292, AL045990, AL040571, AL041346, AL041142, AL040332, AL043941, AL039338, AL079878, AL040529, AL135012, AL041233, AL037341, AL041197, AL046330, AL044274, AL040745, AL040370, AL040128, AL079852, AL039432, AL040553, AL048677, AL047036, AL045989, AL040342, AL041186, AL040414, AL039744, AL041277, AL040285, AL040155, AL040091, AL044165, AL041131, AL040090, AL037279, AL041051, AL040168, AI318479, AL047611, AI547291, AL043775, AL045891, AL042655, AL041278, AL041344, AL040253, AL041227, AL040082, AL042420, AL045857, AL042523, AL042931, AL045494, AL042802, AL042508, AL040329, AL043089, AL042741, AL040255, AL043321, AL047092, AL040238, AL042488, AI432644, AL046356, AI623302, AI431307, AI431316, AI431238, AL043444, AL042515, AL038024, AI432666, AL042533, AL079953, AL043239, AL042842, AL043166, AL048714, AL043091, AL047340, AL040263, AL042853, AL041862, AL042832, AL042729, AI431246, AI432653, AI431323, AI431321, AI431315, AW081103, AI432650, AL048657, AL042787, AL042519, AL043278, AL043295, AI432654, AL043196, AL040207, AI431235, AL045725, AL047675, AI432656, AI866786, AL042468, AL039915, AI866465, AI815232, AI801325, AI866691, AJ238010, AR064707, AR066494, A93923, D17247, AL133053, AL122101, Y17793, AL133074, AL133049, A93916, A85203, A93931, AL133076, AL133082, AL133068, AR023813, and AF019249. HCHAH04 2571 487985 1-61 15-75 HCHAG52 2572 726081 1-395 15-409 HCDMF96 2573 796196 1-418 15-432 AI459248, AI701427, AI023601, and N91037. HCDME32 2574 863374 1-593 15-607 AA405957, AA416555, T19219, AL134902, AI142134, AL119355, U46349, AL119457, AL043004, U46346, and AR066494. HCDMC86 2575 785134 1-316 15-330 AI675751, AA977468, AW183837, AI208676, AA401383, AI184678, AI016502, AA448192, and AA927251. HCDMC25 2576 677627 1-565 15-579 H10593, and AI221385. HCDMC23 2577 675490 1-354 15-368 HCDMC22 2578 672815 1-228 15-242 AL119791, AI318280, AI611348, AW149236, AI252023, AI590830, AI567351, AI886753, AI866798, AL040241, AL038445, AI446373, AI285826, AI345745, AI446538, AI680498, AW268122, AI340603, AA572758, AL036631, AI288285, AW161579, AI312428, AI923989, AI567612, AI866770, AA012905, AI783504, AW163834, AW302965, AL036638, AI348854, AL040169, AI537677, AI802240, AL121463, AW088899, AI345347, AA420722, AW151138, AI538885, AI500659, AI570861, AI917252, AI648684, AI431424, AI499986, AI589267, F37471, AI500523, AI865906, AI246319, AI335426, AI590423, AI348777, AI457188, AI889168, AW132034, AW188382, AL036146, AA493647, AI633419, AW089572, AI926800, AI815232, AI249497, AW074993, AI349614, AW238730, AW268253, AA225339, AI312152, AI284131, AI873644, AW149227, AI345735, AI344785, AI627988, AI923370, AI569583, AL079963, AL038605, AI620284, AI254727, AA640779, AI349937, AI445992, AL120853, AI349645, AI874166, AL045620, AI500061, AI670009, AI433157, AI254042, AI702073, AI610402, AW087200, AI801793, AW022682, AI281773, AW105601, AI871709, AI823670, AI500662, AW073898, AI633125, AI698391, AI801325, AI340627, AI915291, AI916419, AI349772, AI627985, AI582932, AL048656, AA613907, AI521560, AI889189, AL040243, AL045500, AI621179, AW059713, AW269097, AI612885, AI888661, AI251221, AA833760, AI499263, AI284517, AW193134, AI500706, AL038565, AW167918, AW169604, AI862144, AI696626, AI866573, AI890806, AI554821, AA579232, AA635382, AI336495, AI955906, AW198144, AI610645, AI436429, AI950664, AI065027, AI309401, AW020693, AW118382, AL119863, AI343112, AL036980, AI348897, AW026882, AI254226, AI689420, AL042627, AI440263, AI349598, AI950892, AI683585, AI539771, AI273843, AI866608, AI682841, AI539808, AI744256, AW302992, AI445237, AI497733, AL036274, AW084056, AI686877, AI446795, AI281779, AI434256, AW068845, W33163, AI933589, AI620639, AI867042, AI696819, AL038779, AI869367, AI889147, AL036403, AI468872, AI280661, AA528822, AI699011, AW025464, AI754897, AI537617, AI919345, AW088903, AI500077, AW169653, AI494201, AI758613, AW081255, AW152469, AI251830, AI635492, AI366549, AI636719, AI539153, AW151136, AI281800, AA974049, AL036396, AI918449, AL039086, AI682743, AI587121, AI570807, AI611743, AI679504, AW071349, AW071417, AW083804, AI889148, AW301300, AI684265, AI589993, AL036664, AW075207, AI349256, AL036802, AI753683, AW089272, AI277255, AI439601, AI699857, AW268072, AA804740, AA420758, AW075084, AI345608, AI270183, AI608936, AI364788, AI491776, AI334884, AI307543, AW160386, AI699865, AW130534, AF118090, AL050393, U42766, AL117460, AR011880, X70685, AL133565, I89947, AF104032, A08916, I48978, AF061943, A08913, AF090896, AF078844, A08910, A08909, AL049938, AF090901, AL117585, AL133557, I89931, U00763, AF113690, AF113694, AL137521, I03321, I49625, AL133016, AF097996, AF106862, AL137550, S78214, AF125949, AI2297, AL050138, E03348, AJ242859, AL117394, Y11254, AF017437, AF090943, AL049314, AF090900, AL050116, AL050146, AL117435, AF118094, AF118070, AF111851, AL110221, AL096744, AF113013, X82434, AL137557, AL122050, AL122093, AL133113, U35846, AL122121, AL049466, E02349, AL133606, AF026816, AF113019, AL110196, I33392, AF113699, AL050149, AL050277, I48979, A90832, L31396, X65873, L31397, AB019565, Y16645, AL137271, AL049452, AF113676, AF158248, A58524, A58523, AL080124, AL117583, A07647, X93495, AF113691, X72889, AL049464, S61953, AL137283, AF118064, AF067728, I17767, AF090903, AL110225, X98834, AL049283, X84990, AL050108, AF057300, AF057299, U72620, AL080060, U67958, AL049382, M30514, AL117457, AF125948, AL133568, AL133560, A93016, AL137463, AL122110, AF091084, AF090934, AF113677, I26207, X87582, AL050024, A77033, A77035, AF087943, AL133640, AL137459, AF183393, AJ238278, E07108, U80742, A03736, X63574, AJ012755, AL137479, X96540, AL049300, A65341, AJ000937, AL133080, AL049430, I42402, Z82022, AR059958, AF026124, AF177401, AF079765, E07361, AL122049, AL137648, U91329, AL133093, AF079763, AL137538, Y09972, S68736, AF003737, AF113689, Y11587, AF146568, AL137527, A08912, AL122123, E05822, AL133098, AL133077, E15569, Y10655, I09360, AL080159, AL122098, AF017152, AL080127, AL133075, AL080137, L13297, I00734, AR038854, AL133104, AR038969, E00617, E00717, E00778, AL110280, E08263, E08264, AF119337, AL133067, AJ006417, AF061573, AL110159, AL137556, AF106827, AL133072, AL137560, A93350, U68387, X83508, AL133014, AR034821, AF111112, AF100781, AR000496, U39656, Z72491, AL133081, AF153205, Y14314, AF185576, E04233, U58996, L30117, AL117649, I66342, AL137526, AL096751, AF162270, AL110197, Z37987, AF016271, AF111849, AL137574, AL080074, AR054984, E08631, AF182215, AF067790, AI8777, A08908, X92070, U96683, A45787, AL117440, U78525, AL137480, AL137476, S75997, AL137533, Y07905, AL133031, AF008439, AL049347, S36676, AF051325, A76335, AL050092, and AL137478. HCDMC06 2579 934663 1-364 15-378 AI249688, AW265688, AI077941, F00533, AA904275, AW341903, R70333, H71250, AI185394, AW380074, AL046746, AA779783, AI640411, AI287921, F23327, AA504878, AA640260, AW271904, AA177075, AA526193, AA593471, AI803809, AI446205, AA569190, AA381762, AA745356, AI205181, AW275719, AA847029, H82416, AA342189, AA657835, AA664604, AI536625, AI281474, AW408063, AI754037, AA310557, AW270768, AI915081, AI824541, AL039187, AI038304, AI569100, AW192599, AI754105, AA598927, AW131356, AI755214, R91827, AW157005, AI754567, AA262752, AI028510, AW008074, AI624528, AW383952, AI338426, AL120976, F00982, R70883, AI080307, AI570943, AA743811, AI872503, AA992126, AI291037, H91844, AW277174, AW069450, AI859438, AI580707, AI581486, AW268190, D58782, AA805841, AA666215, AI377413, H96518, AC006121, AC009248, AL034420, AC006044, AF107885, AC005089, Z93017, AL009181, AC007967, AC005071, AC004217, AC000041, AC005971, Z99716, AP000553, AC004531, AF038458, U91326, AC002350, AC005037, AC008372, AC006285, Z84480, AC003101, AL035450, U02047, AC004253, AC005944, AL023803, U95739, U62317, AC016025, AC005740, AC005064, AC005562, U73649, AP000252, AL049776, AC005632, AC005516, AC002059, AC006211, AC000134, U91321, AC005730, AC006026, L48038, AC002398, AC007012, AC009516, AC019014, AL139054, AL132777, AL021394, L78833, AC002477, AC002544, AP000212, AP000134, AC006277, I34294, AC006064, U07000, AC006130, AC004797, AC007327, AL049589, AF178650, AL109939, AC006538, AP000106, AC007225, AC004975, AL021391, AC004633, AL031577, AC004000, AC005069, AC005726, AC005696, AL035410, Z82208, AL023807, AL096791, AC007363, AL022326, Z79997, AC007686, AC006449, AC005670, AP000692, AD000833, AL049692, AL121767, AC004883, AP000245, AL035045, AB001523, AL021368, AC002375, AC005664, AB020865, AC000026, AL022336, Z74617, AC005539, AC007242, AC007666, AC004757, AF222686, AL078611, AL024508, AP000115, AP000359, U85195, AL049745, AC005756, AL049757, AC004596, AC002310, AL031281, AC005988, AL031662, AC007308, AL022400, AC007387, AL035659, AE000658, AL080243, AL022165, AC004859, AC005755, AC006237, AC007785, Z93023, AP000348, AC004196, AC004765, Z83826, Z82201, AL031053, AL049709, AC009275, AC002073, AC004832, AC007450, AL031311, AC002041, AL049780, AC005924, AC004796, AL109827, AC005550, AC005488, AC006359, AC003661, AL021154, AC005681, AC006354, AC004848, AC002563, Z82176, AC005901, AC000052, AB023048, AL035610, AC007227, AL035458, AC005829, AP000966, AB020864, AC005878, AL022724, AL031848, AC007676, AC008072, AC006241, AC007784, AC002476, AC006965, AC005932, AC002377, AP000343, AC005914, AC000353, AL035420, AC004019, AC006166, AL049761, AC005055, AP000128, AP000206, AC002480, AC009263, U29953, AL008635, D87675, AL024498, AC005180, AC007221, AC010077, AL109628, AC005184, AC004913, AC007999, AP000030, AC005377, AC005899, AC007688, AC007066, AC006578, AL031297, AP000558, AJ010597, AL021366, AC005778, AC004148, AL035530, Z85986, AC004520, AC005962, AL049554, AF095901, AC006486, AC005536, Z82181, AC004003, Z82244, AC000075, AL035455, and AC004447. HCDMB91 2580 789551 1-330 15-344 AA297443, AA564510, H01110, AA730795, W96277, AA020873, AA947369, AC005031, AL008719, U80017, AC005015, AC004996, AC002511, AC004655, AC002991, AC002477, AC004253, AC005231, AC002565, AC003665, AC006312, AC005837, AP000556, AL034379, AP000557, AP000552, AC006275, AP000247, AC004216, AC007919, AC005484, AC005529, AC002301, AC005821, AL031673, AC006449, AC000025, Z98742, AP000106, AL034421, AC000379, AC005527, AL049869, AC002404, AC002365, AC005924, AC005102, AC000003, AC016025, AL023807, AC002312, AC005081, AC003950, AL049757, AL109758, Z99774, AC004019, AC004531, AL135744, AC005288, AL022165, AC005071, AC007225, AL022721, AL109628, AL021878, AC002470, AL096701, AL050350, AC000353, AC005736, AF196969, AL021155, AC005730, AF053356, AC004125, AL080243, AC004702, AC000052, AC006121, AC004890, AC007151, AF196779, AC004967, AC005921, AC005520, AF129756, AF111168, AC007688, AC005911, AC002300, AP000514, AC004832, AC004477, AC007055, AC007637, AC002310, AC004098, AL023553, AC004910, AL031255, and AF111167. HCDMB42 2581 713300 1-230 15-244 HCDMB41 2582 711996 1-563 15-577 AI525277, and AA079259. HCDMB27 2583 682389 1-323 15-337 HCDMB12 2584 968918 1-613 15-627 AL134524, AI142134, AL038983, AL045328, AL037727, AL042898, AL047163, AL049018, AL038838, AL037343, AL039643, AL037436, AL037335, AL037323, AL037443, AL038532, AL044125, AL047012, AL040193, AL044162, AL037435, AL041347, AL040621, AL043538, AL043496, AL040464, AL038761, AL038822, AL043923, AL043814, AL041238, AL044186, AL040617, AL040463, AL047170, AL043845, AL041324, AL045327, AL044037, AL041635, AL040294, AL041098, AL047219, AL044064, AL041459, AL041577, AL047183, AL040625, AL045684, AL041752, AL042135, AL046850, AL040768, AL046994, AL040510, AL046914, AL043467, AL040052, AL040444, AL043677, AL040839, AL043492, AL041602, AL044074, AL041730, AL041523, AL043627, AL041374, AL043848, AL043570, AL134110, AL041163, AL046442, AL045753, AL041133, AL040576, AL045671, AL040322, AL039316, AL041096, AL041246, AL040472, AL041296, AL046392, AL040119, AL044272, AL041086, AL044258, AL047057, AL047037, AL042096, AL041168, AL041955, AL041159, AL045920, AL040148, AL041358, AL039360, AL037295, AL040458, AL044187, AL041233, AL041292, AL041346, AL045817, AL045990, AL040571, AL041142, AL040332, AL039432, AL040075, AL040529, AL039338, AL079878, AL041197, AL047036, AL046330, AL038745, AL040745, AL040370, AL044274, AL044199, AL040128, AL040149, AL037341, AL040342, AL040553, AL041186, AL041277, AL040414, AL039744, AL040285, AL040155, AL040091, AL044165, AI547295, AL041131, AL040090, AL079852, AL041051, AL045989, AL043941, AL040168, AL044201, AL043775, AL046327, AL040253, AL041227, AL037279, AL040082, AL045857, AL043444, AL079977, AL040329, AL041278, AL119324, AL038878, AA585439, AL040263, AL040238, AL040255, AL045725, AL041140, AI541205, AA585453, AL039915, T18597, U46344, AL043612, AL044529, AL119457, AL038651, D29033, AI557808, AL041344, AI541321, AL119511, AI525556, AI557082, AL135012, AI557602, AI557731, AW392670, AI557238, AL049069, AL041210, AI541027, AI525500, AL048677, AI541346, AI557262, AW372827, D59436, AL043152, AL045891, R45895, AA174170, R29218, R28895, AA283326, T10982, AI547291, C15737, R28735, R29445, R28892, T11028, AI557864, AI431323, AL047611, R29177, AA585476, R28967, R28965, AI535813, AL079953, AL042655, AI318479, AA585329, AA585101, D61254, Z28355, AI546875, AI557734, AI525306, AL043537, D57491, AL045211, C16300, AL043168, T23957, T23985, AI541356, AA585325, R29262, AL047092, Z32822, AI526184, AI541508, AI525431, AR064707, AR066494, AJ238010, A93016, AR023813, A58524, A58523, AF082186, D17247, A93923, AL133053, AL122101, Z32836, I62368, I05558, A60212, A60209, A60210, A60211, AL133074, D50010, D13509, AJ244003, AJ244004, AJ244005, A22738, E13740, Y16359, 108389, X81969, A98767, A20702, AL133049, A93963, A93964, AR062872, 163120, AR062871, AR017907, A43189, AR062873, A43188, A20700, A25909, A98420, A98423, A98432, A98436, A98417, A98427, D78345, E03627, I48927, A35537, A35536, A02136, A04664, A02135, A04663, I84553, I84554, E17098, I06859, A18050, A23334, A75888, I70384, A60111, A23633, AR007512, AR060234, A81878, AB025273, AR038855, A90655, D13316, A02712, A77094, A77095, A95051, AI8053, A64973, Y17793, AR031566, I00682, A86792, AI1245, AI1624, AI1623, E00609, AI1178, E01007, I13349, AI0361, I08396, AR043601, I03331, A93916, A85395, A70872, A85476, I44681, X83865, I19525, A84772, A84776, A84773, A84775, A84774, AR067731, AR037157, AR054109, AR067732, A58522, A91750, AR063812, M28262, I15718, AF149828, I05845, Y14219, I15717, S60422, I01995, E12615, A02710, AR035193, A92133, E14304, A07700, AI3393, AI3392, AR031488, I13521, I52048, A27396, I25027, AR027100, I49890, I44531, I28266, I21869, I26929, I44515, I26928, I26930, I26927, A91965, I44516, A70040, E16678, A82653, I08051, P16636, AF019249, A24783, A24782, A95117, AJ230935, AJ230972, A06631, A85203, A81671, A22734, AJ231028, I08395, A93931, A16035, I66495, I66494, I60241, I60242, I66498, I66497, I66496, I66486, I66487, AJ244007, AJ230902, AJ230845, I03669, AL133076, I03668, AR051957, AJ230951, A20699, P00696, P00697, P03813, I66482, AR009151, I66485, I66483, I66484, AR038066, AR027099, AJ231009, AJ230867, I33632, AR051651, AR051652, AR035975, AR035974, AR035977, AR035976, AR035978, E03654, AL133082, AR008429, AL133068, AR054723, A22739, AJ230996, A05993, A05991, and AL133020. HCDMB08 2585 958542 1-255 15-269 AA719107. HCDMB03 2586 923316 1-375 15-389 AL119691, AI305766, AW103758, AI284640, AI247199, AA634889, AA679532, AI345681, AI345675, AA584167, AA551552, AI345157, AI344812, AI473475, AW274346, AA747070, AW021207, AW072923, AL043009, AW069769, AI696962, AA515909, AA613203, AA551503, AW419262, AW264934, AI801482, AW265385, AI754336, AW088846, AA167055, AA580808, AI133164, AI334464, AW440545, AI754253, AI469968, AA493975, AL045526, AA683258, AA812281, AW193265, AI345418, AI457397, AW302903, H70994, AI888752, AA478355, AI687343, AA630362, AL038072, AW302013, AA521323, AA490183, AI350211, AW438643, AI872020, AA521399, AI859438, AI334443, N35896, AA303007, AA662225, AA515549, AL138396, AI270117, AA502860, AA483771, AA806796, AI471543, AA083046, AA526787, AW301554, AA831375, AI860013, AL134972, AL038474, AL046409, AW103509, AI634384, AA482768, AW131249, AI262909, AA661921, AW020340, AA220943, AI754658, AW276817, AA525824, AL120775, AA829223, AI554718, AA878438, AA603185, AL037040, AA514854, AW276827, AI698447, AI053672, AA577906, AA533725, AI245679, AI688846, AA459749, AA503258, AA507824, AI254913, AA244357, AA501821, AA722372, AI613280, F27407, AA483936, AA372481, AC006128, AC008372, AL023575, AL023880, X54181, AC006323, U04355, X54180, X55926, U18391, AL031734, U18395, AL132766, U57005, U18394, Z82976, AL035079, U18387, U57009, AC005932, U18398, X55929, U18396, X55927, U57008, AC009509, X55925, AL023284, AC000115, AL021395, U18392, AC005756, X54178, X55931, X54175, X55932, U18388, AC005409, AC005821, U57006, X54179, AC006441, X55933, U18399, AC000353, AL021154, Z85986, AC006077, AL021394, AL021877, U67831, AC004859, L47228, Z99128, AC002312, AC005291, Z82198, AL050306, AC005702, X55922, Z95113, AL109657, AC007386, AC000379, AC005520, U67825, AL109985, X55924, AP000501, AC005251, AC005971, AP000230, AC002300, AL049759, AP000144, AL078593, I51997, AC006045, AL034350, AC006101, AF008191, U40455, AL133243, AP000509, AC005159, AL049830, AC012627, AC004678, AL021546, AC007690, AL050332, AL035414, AC005193, AC006965, X54177, Z84482, AL031597, AL035420, AC007751, AL109967, AC007688, AC002395, AC005998, D84394, AC005037, AC018769, AL035703, AL136295, AC003029, AC005212, AC005683, AL049636, AC003030, U67826, AL008719, AL031276, AC002470, AC002115, AC006978, AL080239, AL031577, AL034421, AC005288, U63630, Z84488, AL136504, AC006468, Z97632, AC007917, AC006019, AC006959, AC004598, AC004841, AL035458, AP000154, AJ133269, AC007216, AL050348, AC006292, AC004991, AC007066, AL031664, AC002472, AC005226, AC003982, AC003037, AC004383, AL050337, AC004999, AC002365, AC005695, AC002418, AL109963, AC006060, AC005406, AL035587, AC002310, AC005255, AC005535, AC005229, AC007041, AL121769, AF029308, AC005274, AC008055, AC005844, AC007277, AC002543, AC005772, AC004381, AC000080, AC005300, AF077058, AL031229, Z86061, AC004966, AL049845, AC004751, Z95116, AC005041, AL034375, AC005341, AC004690, AC000120, AC005204, D83989, AC004020, AC004854, AL022477, AC005839, AL135744, L44140, AC006254, AC008044, U35114, AC005915, AC007225, AL033523, Z98200, AC009399, AL035071, AC002385, AC006023, AF015151, AC005886, AP000946, AC005593, AC005944, AJ246003, Z93020, AF130343, AC004990, AL109847, Z98050, AC005261, Z85987, AC016831, Z93929, AC004152, AC002550, U07562, AC005182, AC002369, AC007666, AC005154, AC007899, AC004894, AC003689, AC007371, AL121655, Z97635, AC004972, AC005256, and AC005779. HCDMA20 2587 669201 1-331 15-345 N62789, N62508, AI289289, N62494, AA936576, R52810, N49008, Z39305, R17666, F02223, H11727, R51380, N93902, and AL119444. HCBND03 2588 922388 1-864 15-878 AI702961, AI630765, AW341780, AA931671, AW452292, and U46356. HCBMZ07 2589 951788 1-345 15-359 N30431, AA579184, AI791610, AA176605, F19258, AW438916, AA015691, AW265654, AI305766, AW157005, AI028510, AI620585, AI565245, AI783911, AA772016, AA879053, AA992126, H79308, AA904137, W21392, AA128757, AA947837, AA077817, AA657835, AA230143, AA743811, AI090334, AI051037, AI982634, T40612, F29989, AL043098, AA865262, AL039309, AI244254, AI709174, AI358071, AW274197, AI821467, AA054106, AA300061, AI951436, AI499094, F31654, AI358229, AA226584, AW406755, H72688, AI365988, N52796, AA747243, R85717, AW339687, AW069807, AA629702, AI635272, AA743956, AL049610, AC002350, AC009396, AP001138, AF067846, AL049633, Z83819, Z98051, AC002418, AC005412, AL031774, AL031393, Z72521, AP000691, M87914, AC002369, AL031846, AC007304, AC005164, AL033381, AC006160, AC004651, AL109627, AL022313, AP000011, AP000152, AF140763, AL009172, AL021918, AC004904, AC005940, AC001066, AC006254, AC004386, L81893, AC004381, AC004231, AC002425, AC005736, AP000348, AC006539, AP000045, AC007736, AL050333, Z83843, AP000114, AC005971, AP000503, AC008134, L35681, AF001552, AL049856, AL121655, AC004019, AC002316, AC005832, AL133245, AL008731, AC004983, AC007226, AC004882, AC007055, AC005914, AC005390, AC007450, AB023052, AL031673, AC002059, AC004388, AL031053, AF148319, AC005578, AC004167, AC009510, AC005003, Z84480, AP000047, AC006409, AP000557, AL109980, AF196779, AC009516, AC003101, AL109628, AL096791, Z83840, AC002558, AL022578, AC004253, AC006381, AF091512, AC006037, Z85987, AC005062, AL021392, AF053356, AC004594, AC005365, AC006077, AL031005, AL096699, AL031391, U91321, AC005796, AL050307, AP000556, AP000513, AP000115, AL031662, AC012099, AF061325, AC005703, AC007514, AC001530, AC005484, AP000356, U14702, AC012384, AC005907, AL022143, AP000308, AP000048, AC004699, AL049745, AC002295, AL080317, AC006552, AC004027, AC003982, AF147277, AC002565, AL033518, AC012627, AL021395, AC006948, AC005838, AC005212, AC006011, AC004087, AL031770, AC000041, AC020663, AL137434, AP000690, AJ003147, AC004678, AL049588, AC007263, AL096701, AC005785, AC004134, AC002487, U63834, AP000502, AP000517, AP000032, AL049694, AL121825, AL109799, AC005837, Z84572, AC004460, AL021878, AC005089, AC004453, Z70289, AC005406, AC008394, AC007676, Z85999, AC006057, AC005972, AC007041, AC004963, AC003037, AC007536, AC007308, AF106656, AC004988, AC004805, AC003954, AC005399, Z85996, AC005366, AC002470, AC005839, Z81369, AC005808, AC004832, AC004263, AB023054, AL049828, AL035422, AC005071, AC005523, and AC006166. HCBMY10 2590 961718 1-478 15-492 T53770, AW069769, AA487272, AI612070, AA582073, AA832175, AI611533, AA760808, AA508359, AL037771, T11828, AI252274, AI732378, AA559241, AA503475, AA527602, AA531079, AA493708, C18840, AA469451, AI133297, AA828802, AA828781, AW021583, AA640685, AI439910, AI270117, AA527727, AW276935, AW023990, AI382825, AL038705, AI561060, AI282479, T29611, AA601642, AA602954, AA809546, AA283730, AL036037, AI687343, AI434695, AA477122, AI754955, AA515905, C18521, AI950671, AA955031, AW021917, AA503258, D82454, AA458703, AA908285, T07039, AW022834, AI933714, AA846935, AA569471, AA548058, AI732151, AA587516, AA502155, D83989, AL135744, X54171, AC008015, AC002091, AC004263, AC005412, X54175, AC004859, AC002302, AC005387, AL022326, M37551, AP000512, AL109798, AC006509, X55926, AL035658, AC004900, U67829, AC005619, AC005399, AC004883, AC004837, AC004893, AC005736, AC006036, AC005971, AL034420, AL031311, AC002352, AC005914, X54178, AC007395, AC004231, Z93241, AP000349, AC006468, AC006023, AC005480, X54181, AL096763, X55933, Z84719, U18399, AL079304, AL022726, AC006115, AC004149, AC004821, X75335, AC005296, U18394, AC004963, AC006285, AC005303, AC007731, AC005500, AC004999, AC000134, U66059, AL031279, AL031680, AC004386, AL034582, AC007199, AC007263, AC006530, AC006539, Z84480, Z83844, U18391, U18395, Z82173, U95743, AP000334, AC007386, AL096776, AC004230, AC005568, AC005184, AC004655, AC005057, AC005484, AL022165, AJ239321, AL031683, U18396, AC005368, AC004474, AC007226, AC002312, AL033525, AC004659, AC007193, AL035695, AC006040, AC007041, AL034553, AC006144, AC004531, AL035461, AC004794, AC002059, Z82203, AC006139, X55924, X55925, AL121588, AP000514, AL022313, AC005772, Z94802, AL021878, AL023494, AF053356, AL023553, U57005, U80017, AC002400, AP000173, Z82178, AC006556, AP000275, AC004019, Z98752, AL035457, U57007, AC006552, AC005944, AP000105, AP000037, AC005753, AC004485, AC007917, AC005004, Z79997, Z81370, AC003982, AP000172, AP000065, AF100617, AC004033, AF067844, X55923, AP000057, AP001054, Z83838, X55929, AC007631, AC005291, AC004972, X54180, AC005372, AP000125, AC004895, AL109627, AC005510, AC002565, AL133245, AL023807, AP000355, AC002375, AL049795, U18392, Z95152, X54179, AC000353, AC005243, AL121603, AL078611, AP000557, AC007371, AC004841, Z97053, AL023694, AC002476, L78833, AF196779, AC004388, AP000031, AL121655, AC005225, AC005544, AC007842, Z84466, AB023048, AC005738, AC005488, AL096791, AC005725, AP000114, AP000046, AP000511, AC003108, L78810, AL035086, AC005326, AC005520, AL035415, AC002430, AC005218, AC004049, AC004209, AC005251, AL049570, AB023049, AC004675, AC005102, AC003070, AL035555, AC008038, AC006195, AC003029, AC007384, AP000113, AP000045, AC002460, Z99128, U57006, AF165138, AP000135, AC005778, AC005031, AL078639, AC006261, AC002082, AC005899, and AF111168. HCBMG11 2591 965394 1-685 15-699 AI680459, AI022295, R25336, AI917581, N76313, and AA478089. HBZ5K04 2592 926407 1-65 15-79 HBZ5G02 2593 920249 1-414 15-428 AI733802, AI733182, AA948110, and AI261960. HBZ5D32 2594 699335 1-415 15-429 HBZAJ73 2595 764479 1-489 15-503 R84573, R88849, H50890, and X69908. HBZAJ26 2596 681879 1-640 15-654 W93922, and AF080623. HBZAJ39 2597 847621 1-1325 15-1339 T56623, T57310, AI499938, AA601218, AI679782, AI284640, AL043009, AL046409, AI963720, AI334443, AA610491, AW303196, AL079645, AI431303, AW301350, C75026, AW193265, AA630362, AI471534, AI270117, AW406755, AA521323, AA631507, AI471543, AW327868, AA669840, AW274349, AI350211, AW419262, AI860020, AI345681, AI345675, AA394271, AL119691, AI567076, AI912322, AI613280, AI732120, AI206785, AI683577, AI569086, AW243960, AW088846, AI143242, AI469624, AI005388, AL042856, AI312309, AI358229, AI262909, AA680243, AW338086, AA521399, AW131249, AW439558, AW276827, AW408717, AL048925, AI469968, AA584752, AW069481, AI061334, AI471481, AW270270, AA682912, AL042420, AL138455, AI537955, AI561060, AI281881, AA491814, AI371070, AI571512, AA127353, AL042753, AI298710, AI345654, AI937850, AA569471, AI151261, AI619997, AI623898, AI688846, F36273, AI336660, AI085719, AW167267, AI049634, AI053672, AW167372, AW193432, AI365988, AI079910, AI286356, AL044940, AW406162, AL041706, AA133986, AW407578, AI148277, AL138265, AW023672, AI375710, AL037683, AI110844, AI670124, AI865905, N35896, AI357551, AI954260, AA074130, AI110770, AI754658, AA649642, AI635818, AI282832, AA490183, AW162489, AA714453, AW406659, AI110760, AI434695, AA780515, AI246119, AI287651, AI435544, AI344844, AA350859, AI801591, AI053786, AL043719, AW276817, AI305547, AA226153, AI744995, AI859742, H71429, W79504, AA192740, AW410400, AI951863, AW073470, AL119984, AW247819, AL041690, AI610920, AW276435, AI640702, AW021917, AI888752, AA178953, AI610159, AI279165, AI358343, AI038833, AI761471, F29989, AW339568, AW302013, AA587256, AA713815, AL120687, AI590689, AI590958, AI355224, AI499503, AA226715, U95742, AC007216, AC006948, AC007066, AC007055, AC002115, AC007387, AL022323, Z94721, AP000135, AL023284, AJ003147, AC004463, AC005620, AL022237, AC007664, AL049569, AC005041, AP000031, AC005696, AC002472, AC002375, AC012384, AC005488, AF067844, AC006014, AL034423, Z82244, AC003689, AL049780, AC007242, AC004974, AL031680, AC005104, AC002119, AL031311, AP000044, AP000112, AC005914, AC005971, U47924, AF196779, AC005182, AC010349, AJ246003, AC005217, AC003101, AL035417, AC006064, AC007279, AC005527, AC005412, AL121603, Z84488, AC005043, AL121655, AC004000, AC006251, AC005902, Z74617, Y07848, AC006271, AC008009, L78810, AC004967, AL049709, AC002565, AL133382, AC002059, AC005619, AC004125, AL110502, AC004491, AL031075, AC005932, AC005529, AL121658, AF049895, AC004776, AC004686, AC004061, Z68276, AL031668, AC005399, AL021707, AL021546, AC004858, AC000026, AC005356, AL031673, AC015853, AC007011, AC005280, AL022322, AC005786, AC007240, AL133445, AC004963, AC005076, AL132985, AC005300, AC006449, AF002223, AC006019, AC018633, AC007546, AL008715, Z49236, AF135028, AC002316, AC008372, AC005531, AC000025, Z97989, AC006480, AL096791, AC002301, AF217403, AC004526, AC004020, AC005231, AL132712, AC005520, AC004703, AC006030, AC005330, AC008044, AC004841, AL035079, AC005832, AL035685, AP000503, AL031733, AC000159, AC005486, AC005618, AC008115, AC003003, AL133353, Z97054, AL035422, AC004539, AC005291, AC000052, AL133245, Z81450, AC007192, AC004652, AF129756, Z82202, U78027, AC005202, Z86061, AL109798, AL031588, AC004382, AC004585, AC006112, AF109907, AL034429, AC006130, AC004019, AC005015, AC004659, AF107885, AL078477, AC007040, AF165926, AC004876, AC004181, AJ251973, Z85987, AL121652, AL031255, AL021391, AC005740, AC004236, AC004990, AL133371, AC006441, AL022328, AC008014, AC002045, AC005071, AC006160, AC005764, AL008718, AL035072, AC002364, AP000477, AC004816, X60459, AP000297, AP001172, AL035587, AC003678, AC004883, AL031848, AC004030, Y14768, AF134726, AL050306, AL020993, AC002425, AC005784, AC005480, AL031602, AC004217, AC006965, AC005355, AL034452, AP000692, AL009179, AC005057, AC005899, AC00810I, AC000072, AC005664, AC005778, Z83822, AC004517, AL031277, AC005803, AC002350, U07563, AL049872, AC007684, AC006116, AL022329, AC006953, AC004408, AF190465, AC006544, AJ006996, AC002492, AL049845, AF108083, AC002126, AL008582, Z83845, Z95114, AC005200, AC004087, AC003684, AP000506, AP000505, AC004865, AC000353, and AC004859. HBZAJ14 2598 847620 1-512 15-526 HBZAB15 2599 660348 1-413 15-427 AA079443. HBZAB08 2600 959560 1-449 15-463 AI806340, AI347581, AW058265, AI149706, AA858304, AA416860, AA910678, AA470052, AI674598, and AA887474. HBNBQ50 2601 887096 1-604 15-618 AA481928, AW370602, AA130551, AA410947, H02520, AA477170, AW362159, AW362184, AI683337, AI151512, AW362163, AW024950, AW362162, AA295138, AW364082, AA434486, AI346658, AI247124, AA434390, AI560635, AI922390, AW193870, AW261977, AI813439, AW050855, AW272323, AI889939, AI633003, AA913117, AI917569, AA862055, AI819001, AA559250, AI589941, AI356811, R72882, AW304202, AI627873, N94336, AA480065, AW130311, AI889450, AW083447, AI631391, AI081435, R93337, AW074375, AW027034, AA527492, W49844, T40555, AI673235, AA010655, H00902, AA211365, AI824358, R66066, AW297543, AA863216, AA568472, AA872583, AA740278, R16077, AW070819, AA877152, AA130587, R72869, AI349088, R72008, AI682945, AI922396, AI682950, AA533970, AA047596, H00901, AA010656, R72471, R15713, R67665, R73357, AI890961, AI801834, AA745829, R73342, AW337286, AW384044, X14856, and A08001. HBNB030 2602 430360 1-442 15-456 H41301, R36910, AA894644, R87213, H15246, T23507, AI222616, and AB002320. HBNBL29 2603 703113 1-397 15-411 R18010, AI680708, and AI635217. HBNBJ29 2604 907015 1-320 15-334 AA935421. HBNBJ06 2605 960664 1-284 15-298 AI369384, and AA719568. HBNBB41 2606 712676 1-601 15-615 H95264, AI680749, AI672415, AI492506, AI633630, AI628076, AA699651, AI090129, N73745, AI434427, AI480111, AW088604, AA988606, AA917930, AA236877, AW300229, AI942393, AJ271713, AI627960, AA701995, AI911527, AI693888, AI765976, AA424737, AI984791, AI672498, N38876, AW300532, N66066, W86671, AI478472, AW271444, AI540292, AI350589, AA505970, AA724554, AA905114, AI141611, AA625745, AI623282, AA677788, AI758154, AA553728, AW243369, AI915897, H39811, AI038544, AA904754, F28995, AA953543, H78001, T69270, T67436, H24986, AA235920, Z19235, AI927054, R08315, H81259, T99814, H26910, AI341446, R05488, R05808, C21030, and H39812. HBNBB27 2607 600905 1-130 15-144 HBNBB09 2608 868924 1-360 15-374 R42401, H17978, AA412292, AA470014, AA632915, AI147693, AI347038, AI308941, AA135185, AA583432, AA836857, AA018749, AA299011, AA528216, AA516435, AA916348, AA514541, N62509, AI350971, AA494556, and AF184971. HBNAW73 2609 764716 1-285 15-299 AI190941, R86172, H25501, and Z99289. HBNAC74 2610 586797 1-140 15-154 AA318750, AA482345, AA281903, AA305550, AA975640, AW411095, AJ130978, and AF099149. HBNAC71 2611 525831 1-305 15-319 HBNAC48 2612 721983 1-338 15-352 AA078532, AC006014, AC005488, AC005049, and AL009172. HBNAC42 2613 714263 1-408 15-422 AA190822. HBNAC32 2614 526549 1-206 15-220 C14348, AI074047, AF007887, AI078283, C14340, N63997, N62637, AI457357, C14382, AI299045, D25956, AW339264, AI347344, AW135793, AI952780, AI337314, AW166959, AL080011, R81679, AW089495, AI440133, AI521589, AA581403, AI634350, AA836392, AI671661, AI281867, AL046227, AW073858, AI832245, AI636588, AL037582, AL037602, AW022682, AI610362, AI817545, AI824746, AI613038, AI583578, AI612913, AI249946, AW023338, AI860897, AW007555, AW161202, AL039730, AI470293, AW087199, AI305745, AI635892, AW132034, AI434969, AI245008, AI628325, AI817373, AI440284, AI289310, AI682891, AI687568, AI432570, AI288285, AW327527, AI538850, AI277008, AI690813, AI285514, AI471898, AI918634, AI933992, AW088944, AI452560, AW265004, AW198112, AW020358, AI491904, AI621341, AI631107, AI699211, AI623941, AL043089, AI954080, AI889148, AL038529, AI587302, AW150308, AI679550, AI678688, AI287446, AW090387, AW058233, AI862135, AL119457, AW264727, AI587156,AI926041, AJ005511, AI682968, AI921633,AW166870, AI476109, AI912434, AW411043, AI934011, AI890051, AI446511, N25033, AW085709, AA814990, AI241741, AW167157, AW366372, AI758988, AI783569, AW194014, AI885999, AI922315, AW161098, AW167926, AI635016, AW026905, AI270039, AI862139, AI929108, AI885982, AW089233, AL121041, AI918408, AI696846, AI537076, AI584130, AI469516, AI698391, AI250627, AI623682, AI683634, AI680498, AI961589, AI828568, AI493567, AI963191, AA848053, AI620639, AI589428, AA693314, AA514684, AI933001, AI890391, AI818562, AI683497, AI269580, AW089387, AI624548, AI927233, AA856697, AW084151, AI697372, AW169234, Z98519, AL048644, AI537187, AI828734, AI361701, AI435253, AW079432, AI918554, AI457188, AI609556, AL120987, AA760655, AI499621, AI884459, AW080076, AI701975, AW268122, AI924686, AI687168, AW118414, AI280561, AA768369, AI363957, AI572017, AI783504, AI282669, AW075608, AI922689, AI374987, AI633061, AI554344, AI802542, AI571529, AI702527, AF113694, AL035458, AL021393, AL035587, AC005091, AC004383, AC004987, AL034400, AL031346, AC007358, AL031984, AC004822, AL137705, AC002287, AL049761, AC004797, AC004943, AC005291, Z99297, AC005225, AF042090, AP000697, AL121603, AC007390, AC007172, AP000514, Z82206, AC005876, AC005250, AC002471, AC005374, AC000053, AP000340, Z49258, Z83840, AC006313, L78810, AL049776, AC004470, AC002467, AC006501, AF095901, AC004686, AP000250, AP000133, AP000211, AP000030, AL034417, AC004213, AC002060, Z98949, AL022165, AC004227, AC007384, AC006039, AL009179, Z83844, and AL035407. HBNAC28 2615 525832 1-307 15-321 AC007539. HBNAC25 2616 525834 1-132 15-146 HBNAC09 2617 525833 1-63 15-77 AA604441, AI690219, AI693458, AA508848, AA447094, AA830582, AI703075, AW003969, AW189292, AW014124, AA831149, AI278956, AI922983, AA908927, AI703009, AA455884, AI870286, AI160778, AI873461, AI636871, AJ245433, AP000504, and AF129756. HBNAC02 2618 921187 1-187 15-201 HBGTT76 2619 903653 1-819 15-833 H62649, AA584581,AA059154, AL043721, AA098922, AA593060, AA443390, AA329321, C18357, C18360, M77895, AA115968, AA365302, AA658235, AW088224, AI921188, AA601270, N43757, AA634855, AI286356, AL138455, AL043756, AA515224, AW117750, AI357551, AI307201, AA630352, AA084070, AI921649, AI929531, AI064952, AI376100, AW162049, F13749, AA665293, N25303, AA655002, AA641103, AL009179, AL096775, Z70688, AL022324, AL034419, AL022318, AL078581, AC005962, D87717, AL035696, U95742, AL049829, AC007068, AC005664, AC000052, AC004019, AF190465, AC004712, AL023494, AL109627, AL035460, AP000512, AC007022, Z82208, AL122020, AC004797, AC004622, AC006332, AC004477, AL031005, AL008582, AL008721, AC004859, M87923, AC005663, AB023051, AC007686, S42659, AC007225, AC004933, AC005406, AC002287, AC005783, Z95114, AL049776, AL035681, AC006138, AC002119, AC005618, AC004027, AC006596, AL034548, AL049875, AC005358, AC005911, AF111168, AC005725, AC005288, AC007546, AC006576, AP000513, AC004526, AC004671, AF072099, L27148, AC004695, Z82188, AP000270, AC000087, AC004972, AC004927, AP000351, AP000131, AP000209, U66059, AL031848, AC004638, AC000120, AL078477, AL008629, AC016026, AP000248, Z98036, AL031782, AC006480, AL133448, AB016897, AL117258, AL023807, AP000032, AC007690, AC004517, AL031296, AC005324, AC005696, AC006211, AP000349, AC007845, AC005081, AL022163, AC004035, AL034420, AC005362, AP000049, Z82178, AP000134, AP000212, AL031291, AP000311, AC007283, AC005808, AL023553, AL031591, AP000080, AL031846, AC006409, AL109628, AC004522, AC007676, AC004890, AC005104, Z85996, AC002115, AL022311, AC006132, AF165926, Z97205, AC006285, AC005342, and AF196969. HBGTE11 2620 965121 1-313 15-327 AW015800, AA251013, and AF037222. HBGQS88 2621 886650 1-436 15-450 AW304683, and AC004152. HBGNL85 2622 848179 1-692 15-706 AW104050, AA738352, AI953035, AI341184, AA995803, and AA911220. HBGND04 2623 926973 1-582 15-596 AI057634, AW182951, AI655334, AA854636, AI218588, AI457916, AA961245, and AA953084. HBGMT82 2624 954374 1-495 15-509 AW007399, AA782657, AI673493, AW104963, AI539419, AI970048, AW272491, AI827847, AI707847, AI201450, AI160580, AI149344, AI719374, AI870582, AW068652, AW131835, AA022523, AI142042, AA689495, AI394166, AI197831, AI452812, AA536006, AA483525, N24911, AI220974, AA994188, AA687451, AA745895, AI808412, AI475847, AA687509, AA733114, AA480131, N78953, AA380438, AW246627, AI749023, AI382254, AA524482, F22287, AA053148, AA689552, AA405870, AI190107, W17347, AI245397, AA482098, AA622680, AI458806, AI143698, AW084279, AA113160, AW304748, AA977756, AI589259, AJ917965, AI061434, AA576098, AF096303, and AF024631. HBGM569 2625 754392 1-438 15-452 N78741. HBGM078 2626 773043 1-474 15-488 AA417275, AA421555, AI863143, AA460243, AI491842, AI540501, AA831948, AI082645, AI969655, AI864102, AI355990, AI923989, AI564629, AL036705, AI924051, AA642437, AA804776, AI567883, AF070643, U02475, AL137258, and AL137254. HBGMG81 2627 880276 1-678 15-692 AA974503, AI986165, AL079812, AA287570, AA255853, AA129446, AL043009, AA866015, AW237905, AA653154, AF039185, AI755214, H96249, AI754105, AI754567, AI656840, AL079734, AI476049, AA488903, H07953, AA521399, AA521323, AI369580, AA013168, AA054085, AI380617, AW419389, AW265385, T74524, AA019973, AW069769, A1110844, AA443390, AL043718, AI431303, AA442528, AI358712, AW419262, AA167792, AA489204, AA613203, AI733856, AA833875, AW023111, AA833896, AA826669, AA491284, AI675615, AI821714, AI792133, AI791913, AA665330, AI815210, AI612142, AI609972, AW271904, AI150401, AI923052, AA769402, AW327868, AW003886, AL118991, R43310, AL119838, AW245747, AI436433, AA719073, AA191418, AA847499, AA682912, AI917132, AI696878, AI792521, AA410788, AA613232, AW021917, AA630362, AI582769, AA563733, AI247101, AI821785, AI732151, AI583252, AW303196, AI687343, AI610941, AL044940, AA480772, AI003972, AA502532, AW026305, AI421950, AI345654, AA669840, AA530958, AW408717, AW270385, AI419337, AW270771, AI963720, AW193265, AI754653, AI056177, AA613227, AA829036, AW020088, AW301350, AA659324, AA581903, H73550, AW265688, AW020150, AL046205, AL042756, AL038705, AA569667, AA714110, AA579179, AA128592, AI345157, AA714011, AI270117, AA468022, AA631507, AI879951, AC007349, AC004913, AL023803, AP000088, AL121603, U85195, AC005291, AC005527, AC007687, AP000557, AE000658, AC005529, AC005694, AC000052, AC007488, AL078593, AL021155, AP000355, AC000025, AL132712, AC005411, AJ010770, AC004167, AP0G0501, AF088219, AC004686, AP000503, AL008627, AL031255, AC000353, AC004019, AC004638, AL078463, AC005355, AC002369, AL096774, AC005225, U96629, AC006480, AC004812, AC020663, AL021918, AL133448, AP0G0505, U91319, AL031659, AC004228, AL133243, AC007536, AC002350, AC002565, AC002347, AC002045, AC006965, AC006285, AC006064, AC005015, AL035089, AP000044, AP000112, AL009181, AC005274, AC006211, AL008718, AF196779, AL023807, AC008040, AF045555, AP000114, AP000046, AL022323, AC005778, AC005488, AC005531, AC004941, AL121652, AC002470, AL031311, AC006126, AC005799, AL035072, AL022326, AL034549, AP001051, AC005859, AL022322, AC007664, AL031668, AC003684, AC005899, Z95152, AL031283, AC007225, AC006449, AL050318, AL121655, AC005996, AC005318, AC005378, U80017, AC005231, AC003101, AC005900, U95742, AL031848, AC006511, L78833, Y14768, Z99716, Z81314, AC002395, AC002316, AF139813, AC002314, AC005295, AL109628, AC005086, AC005701, AC007216, AC006388, AC007308, AC006000, AF001549, AC005519, AC005988, AC005837, AC005756, AC002549, AL023553, AC006111, AC002301, AC004815, AC005207, D88270, AP000245, AC005031, AC005747, AC005088, AC011311, AF030453, AC007731, AC007666, AJ246003, AC007686, AC007384, AL133244, AC002310, AC009247, AC007919, AC007227, AC006130, AC005914, AL078623, AC004797, AC005911, AC005280, AC007395, AL021707, AC005500, Z99128, AC005324, AC007546, AL031427, AL049759, AL034420, AC009516, AC005562, AC006057, AC004526, AC003029, AL050341, AL049748, AC005154, AL096791, AC006213, AC005250, AL049869, AF129756, Z83838, AC002504, AL020997, AC006312, AC004675, U62317, AC006277, AC005399, AC006468, AL109865, AL031662, AL021368, AC004990, AL109827, AP000031, AC002429, AL035417, AC003983, AL024474, AC005206, AC005393, AC003080, AC004878, AC004805, AL035455, U47924, AC007262, AP000504, AC005874, AF134471, AC006252, AC004020, Y07848, AC003006, U91321, AC006023, AC005412, AC005043, AL022312, AC004106, AC004883, AP000692, AC006236, Z98742, AC004659, AC000026, AC007066, AC005783, AC007637, AL035681, Z83844, AL050312, AC007450, AC005184, AC007242, AC005696, AL109984, AC005484, AC007993, AP001037, AC005520, AL121653, AC005011, AC004033, AC005667, AC004584, AC004988, AL121658, AP000553, AL031670, AC006430, and Z85986. HBGF588 2628 914032 1-628 15-642 AA778429, AI563955, AA928041, AA626794, AI871136, W44486, AA071274, AA126250, AA902119, AA029458, AI814680, N70230, AI340231, N67040, AW074273, AI417119, AI027942, AI343619, AA644262, AI080252, AI804089, AA865354, AI186469, AA496355, AI753118, AI868721, N63928, N71035, AI336036, AA861853, AW262673, AA205643, D60248, AI524080, AI969141, AI755095, AW249740, AI955645, D60466, C00015, N98454, AA496405, D60550, AI659597, AI383091, N79606, AI187029, AA128493, D60009, AA512988, AA128352, H94297, AA626779, AI357512, H95828, C14688, T70086, AA649543, AA595243, AI368586, AW022016, T47633, AI672897, AA029523, R73069, AA693672, AA991733, R94710, T83736, AI418701, AW028373, R23240, AI538371, AI954235, AI623761, D81788, AA205642, W01019, AI954237, H94191, AI382863, R33837, AA364340, AA094118, R94790, D81287, W44485, R23316, W19084, N41706, D60973, T70157, R81247, T83907, AI910652, D60249, D81466, AA093704, D60551, AA354560, R33836, R81248, W01933, AI683085, AA383533, T47632, AA093663, H57883, AI355051, and AC005369. HBGFG53 2629 727748 1-461 15-475 AA419551, AW292148, AI791628, AI821482, and AL137722. HBGDH33 2630 702854 1-458 15-472 AI399653, AA453794, R44976, H06251, R60067, AI278851, AA528243, AA973793, AA453879, R44717, and Z40655. HBGDF39 2631 861602 1-341 15-355 D59582, and D59820. HBGDA74 2632 832888 1-474 15-488 AI565755, AI342368, W76561, AA780301, AI200880, AW195697, AA451937, W23209, AA364898, AI050849, H39591, AI028147, AW293972, AI474504, AA324713, AI628717, AA961641, N24530, AF071749, AF136279, AF071748, AF132894, AF088886, AR016587, AL137742, AJ007331, and E15813. HBGBG69 2633 802090 1-43 15-57 HBGBG67 2634 588263 1-192 15-206 R60478, R11939, AI140927, AW166520, AI097082, AI378818, AW070736, AA022937, AI417973, AI278239, AA813598, AW024249, AI143513, R02801, AW024258, AI097158, AI217615, AA128646, AI831140, AA151765, AI348969, AW058275, AI273856, AI537960, AI310767, AA012905, AL048340, AI952433, AI348854, N22406, AI335235, N20984, AA808904, AI860833, R49697, AI673140, AI810317, AW075382, AL047422, AI288076, AI499104, AI539690, AI473554, AL117403, AF115410, U58996, U68233, I92592, AC005902, AR068751, AF100781, AF213396, Y10080, AL117583, AC004227, AC006288, AF013249, AL133081, AF026124, AF181849, AF181850, AI5345, AL080124, AC005221, AR066486, A70386, AF161699, AF082526, AL049300, I80064, D44497, I08608, AF000301, AF137367, AR023871, AL050310, X56530, and AL110222. HBGBG52 2635 522424 1-245 15-259 T71030, AA747777, AA381858, AA668902, AA558060, T90248, AA934680, AA059235, T70174, AA678436, H86264, AC006001, AC002350, AL021546, AC006449, AC006026, AC003102, AC004895, U18671, AC005387, AL133246, AC022517, AC005696, AL021939, AL035072, AC005089, AC005694, AL050333, AC005565, AL121603, AL135744, AC005839, AL008582, AC006960, U95742, AC006277, AC006071, AL022302, AC006241, AL031681, AC005295, AC005004, AC005899, AC002312, AC005785, AL049776, AC002310, AC004253, AC007666, AC006530, AC004859, AC000353, AJ003147, AC004858, AC005081, AC002126, AF196969, AC005231, AC004966, AL035587, AF109907, AC002470, AC005015, AP000688, AC005829, AC004383, AC005529, AC005940, AC004491, AL022322, AC007216, AC004019, AC006064, AC004030, AC007055, AL034420, AC005288, Z83840, D00591, AC007308, AL023803, AC005011, AL049757, AC005776, AC005102, AC007021, AL034423, AP000692, AL109847, AF017104, AP000503, AC002347, AL035659, S77605, Z99716, AP000556, AL031005, AC002369, AL079340, AC007917, AL049780, AC004228, AC005944, AC005971, AC004770, AC004804, AC006312, Z98950, AC002128, AC005527, AC002073, U91326, AC007193, AC002116, AL008718, AC007421, AC002477, AC007637, AF001549, AC002072, AF003626, AC005218, AL121655, AC005500, AL035071, AC003689, AC005622, AL022318, AL050318, AB003151, AL096707, D26535, AL096701, AL022323, AL034350, AC005535, AC004876, Z83820, AC007066, AC007283, AP000115, AL133371, L78810, AC009516, and AC002316. HBGBG38 2636 525837 1-137 15-151 HBGBE12 2637 971466 1-94 15-108 HBGBB78 2638 773930 1-329 15-343 H51141, and D37934. HBCPV80 2639 932817 1-390 15-404 AI306162, AI492835, AC002359, and AC002365. HBCPO75 2640 927520 1-473 15-487 AI017490, AI221329, AA973064, AA813611, AI688144, AI222206, AW182987, AA883877, W31185, AI208514, AI917508, and AI810095. HBCPK03 2641 922493 1-720 15-734 AA831288. HBCJP02 2642 917981 1-494 15-508 AI188098, AW304309, AI375434, AI625524, AI016723, AI167974, AI302664, AW001092, AI246687, AI572643, AI201622, AW151711, AW167729, AI609516, AI687735, AI191064, AI289182, AI191358, AI024836, AA632308, AI831665, AI084459, AI088322, AA242818, AA580006, AI888580, AA011305, AI870130, AW168685, AA010915, AW078807, AI372084, AI217609, AI200991, AW237859, AI263564, AA629134, AI720347, AA862783, AI880912, AA564376, AI879913, AI367291, N74110, Z21520, AA028965, AI349340, AA298576, and AI582057. HBCJG07 2643 951898 1-375 15-389 R82747, R30969, and T87286. HAUCC58 2644 764851 1-390 15-404 AA235095, W63805, W07740, AA302624, AA293831, AA315199, R53208, AI568567, AI992241, AI086596, AW151172, AA309877, AI080304, AA401651, AW090277, AA150647, AA708776, AA142944, AI826693, AA843315, N77987, AW051448, AA527053, N92512, R87425, AI129519, AI031868, AI083531, AI335895, AI039605, AI299184, AI200329, AI148099, AA788733, AA115544, AA389673, AW337779, AA588191, AI141373, H66602, AI192219, AA708520, AA079352, AI076910, AA872411, AA860813, AI160688, AI805893, AA455203, AA769806, AA411491, AA436345, AA493343, AI193844, AI421247, AI167692, AI074899, AI193867, AA249309, F32557, AA722032, N80680, W38964, F24549, T83037, AA402479, AA844466, AI141356, N58395, AA454862, AI161139, AW008542, W93969, W93970, AA336147, R48412, AI378335, T90357, H95941, AA568295, R86694, AA341105, AA228455, AW352337, W30921, AW337638, N74117, AA303783, AA215973, AW009811, R53110, AA558040, AI961636, F24945, AA715148, R49774, F35088, AA228454, AA328964, AA077962, R11503, H87636, AI695590, AA904185, AA398459, AI803601, R86695, AA115055, AA192729, AA889647, and AF151893. HAUAW51 2645 577959 1-336 15-350 AA214667, and H78996. HAUA589 2646 518847 1-164 15-178 AA926970, F27522, F30071, AA096277, AA627396, F33364, AA318284, AI283651, F27676, AW015956, AA947143, AA244132, AA327732, AA352731, AA320725, AA089891, AA317435, AA319168, F30100, AA664996, F29754, F27644, F27760, AI832645, F24555, AI560279, AA306681, AI749712, AI289147, AI130748, AA694164, AI023676, AA244131, F26815, AI039009, F33405, AI309287, AA534561, T74859, F35771, F34894, F35313, W78719, F30920, AA694524, AA524049, AI150756, AI344732, D51606, AA903996, AA864997, AC008044, and AC008372. HAUAQ28 2647 685374 1-520 15-534 AA127594. HAQCF25 2648 678235 1-513 15-527 T63571, AI832218, T63496, AI004915, AI990727, AW381879, AW381818, AW381815, AI254648, AI917020, and AL137725. HAQCD07 2649 958959 1-439 15-453 AI142585, AI082139, AW051999, AA833602, AA719280, AA703255, AI870257, AI952791, AA625853, AI125671, AW104742, AA813022, R44512, AA928937, AI826007, AI921451, AI272168, AL120554, AI928736, R48258, AI453416, AW104741, AI933170, AA350537, T98866, AA364915, T40772, AI784134, AA053022, AA740797, AA350621, AA340417, AI240679, AA308837, H16246, AA053159, AA907088, N86840, AW401390, AI939391, AW071136, H30533, R37449, R37338, AC005781, and AC005581. HACMR08 2650 955638 1-485 15-499 AI292236, AW265393, AI123080, AW069769, AL042373, AW069227, AL038936, AI040051, AW438542, AI216990, AL079734, AA402129, AI887235, AI674946, AA501461, AI733856, AI755214, AW303196, AA469327, AA502532, AW301350, AL120343, AI754105, AA515728, AI754567, AW274349, AI821714, AI792133, AI791913, AW265090, AW270258, AW088846, AW021015, AW237905, AW072923, AW302315, AI354423, AW103509, AW341903, AI859946, AI821785, AA653139, AW270270, AL040054, AA613627, AI696962, AI357823, AL042856, AW407578, AA602906, AI801482, AI267356, AW270619, T67090, AI753488, AI281881, AA582554, AW021917, AA634837, AA715814, AI267450, AI874341, AA704393, AL045709, T74524, AA644090, AI754037, AA584489, AI969436, AA631507, AI282253, AI054333, AW410354, AW277174, AA470344, AA533025, AW117740, AL044858, AA284247, AA595499, AI473943, AI278089, AW302711, AW270768, AA764783, AI889440, AI275982, AI687343, AI081147, AL042756, AI368256, AW190505, AI291037, AW327624, H07953, AI244127, AW263864, AI371249, AA525253, AA613624, AW438539, AI792499, AI017251, AA833875, AA833896, AA192278, AI144081, AI380617, AI369580, AI567076, AL079645, AI291823, AA430137, AI110844, AA634786, AW020992, AI064864, AW021951, AA307598, AW021154, AI917132, AA622801, H73561, AI872216, AL109758, AC002301, AC006077, Z68276, AC005089, AL049872, AC006441, Z82182, AC002306, AC007204, AE205588, AP000251, AC005399, AC006262, AP000212, AP000134, AP000030, AC007371, AC002430, AC005808, AC007384, AC004859, AC006006, AC005632, AP000356, AL022721, AC004257, AC005037, AF053356, AL034417, AC005696, AC002119, AC005261, AL034420, AF196779, AC004515, AC004797, AF111167, AC004878, Z85986, AC005377, AC004253, AC002477, AC005901, AC005519, AC004655, AC002492, AL031433, AL035458, AC006317, AC006966, AC004921, AC004895, AC004477, AL022476, AL133448, AC004858, AC005682, AB023049, AC005060, AC000113, AC005179, AF196972, AC005666, AC008372, AC007055, AL135744, AP000065, AC004967, AL024509, AC007216, AC015853, AC002425, AF109907, AL034429, AC002544, AL121658, AC007684, AC007842, AC002347, AC004106, AC007227, AC006487, AC005332, AC005251, AL031228, AC007226, AC007686, AL136504, AF031078, AC004972, AL079340, AC006430, AL033527, AC005701, AF015262, AF165142, AL050307, AC005694, AL035410, U85195, AL008627, AF030876, AC005200, AJ229043, AC002039, AC005829, AC004098, AC009247, Z98200, AC004686, AL139054, AC004128, AL021918, AC004099, AC004386, AC003101, AC004552, AC005599, AE000658, AF042090, Z84467, AC003093, AC004448, AC007073, AL033525, AC005255, AC004890, AC005324, AC005578, AL031005, AC007225, AF111168, AC005726, AC005821, AL035587, AC005207, AC004408, AL022327, AC005529, U95742, AC006026, AC004236, AC004150, AC005736, AC007052, AF134726, AC000353, AC003108, AF088219, AL022320, AF129756, Z82244, AP000215, AC004263, AC016831, AC008115, AF146191, AC004659, AL035405, AL021393, AC005899, AC002365, AF001549, AC006101, AL021546, AL117344, Z97056, AL133246, AL034548, Y18000, AC003992, AC004707, AF017104, AD000092, AC007899, AC012627, AC005905, AC004590, AP0G0505, AC005874, AF134471, AC004796, AL031117, AL109627, AL049643, AL049748, AC005972, AL049873, AP000252, AL133500, AC004913, AL034555, AC006120, D87675, AL135960, AJ131016, AC007277, AC005378, AC005071, AC003070, AC004841, AC004622, Z97352, AC002350, AC006254, AC006511, Z98742, AL031276, AC003110, D63507, AL096701, AC005216, AC004475, AP000349, Z70288, AL031286, AC005409, AC002073, Y10196, AC005520, AC005057, AF064861, AL049843, AC005102, AC004812, AC002418, AC005295, AC002553, AL110502, AF190465, AL121603, AC000385, AC007546, AL022162, AC005730, AC005484, AC004887, AC004000, AL122023, AC005280, AC003043, AC002504, AL031295, AC007537, Z68269, AF015148, AC008044, AB026898, AL109628, and AI420248.

[0128] TABLE 4 Code Description Tissue Organ Cell Line Disease Vector AR022 a_Heart a_Heart AR023 a_Liver a_Liver AR024 a_mammary gland a_mammary gland AR025 a_Prostate a_Prostate AR026 a_small intestine a_small intestine AR027 a_Stomach a_Stomach AR028 Blood B cells Blood B cells AR029 Blood B cells activated Blood B cells activated AR030 Blood B cells resting Blood B cells resting AR031 Blood T cells activated Blood T cells activated AR032 Blood T cells resting Blood T cells resting AR033 brain brain AR034 breast breast AR035 breast cancer breast cancer AR036 Cell Line CAOV3 Cell Line CAOV3 AR037 cell line PA-1 cell line PA-1 AR038 cell line transformed cell line transformed AR039 colon colon AR040 colon (9808co65R) colon (9808co65R) AR041 colon (9809co15) colon (9809co15) AR042 colon cancer colon cancer AR043 colon cancer (9808co64R) colon cancer (9808co64R) AR044 colon cancer 9809co14 colon cancer 9809co14 AR045 corn clone 5 corn clone 5 AR046 corn clone 6 corn clone 6 AR047 corn clone 2 corn clone 2 AR048 corn clone 3 corn clone 3 AR049 Corn Clone 4 Corn Clone 4 AR050 Donor II B Cells 24 hrs Donor II B Cells 24 hrs AR051 Donor II B Cells 72 hrs Donor II B Cells 72 hrs AR052 Donor II B-Cells 24 hrs. Donor II B-Cells 24 hrs. AR053 Donor II B-Cells 72 hrs Donor II B-Cells 72 hrs AR054 Donor II Resting B Cells Donor II Resting B Cells AR055 Heart Heart AR056 Human Lung (clonetech) Human Lung (clonetech) AR057 Human Mammary Human Mammary (clontech) (clontech) AR058 Human Thymus Human Thymus (clonetech) (clonetech) AR059 Jurkat (unstimulated) Jurkat (unstimulated) AR060 Kidney Kidney AR061 Liver Liver AR062 Liver (Clontech) Liver (Clontech) AR063 Lymphocytes chronic Lymphocytes lymphocytic leukaemia chronic lymphocytic leukaemia AR064 Lymphocytes diffuse large Lymphocytes B cell lymphoma diffuse large B cell lymphoma AR065 Lymphocytes follicular Lymphocytes lymphoma follicular lymphoma AR066 normal breast normal breast AR067 Normal Ovarian Normal Ovarian (4004901) (4004901) AR068 Normal Ovary 9508G045 Normal Ovary 9508G045 AR069 Normal Ovary 9701G208 Normal Ovary 9701G208 AR070 Normal Ovary 9806G005 Normal Ovary 9806G005 AR071 Ovarian Cancer Ovarian Cancer AR072 Ovarian Cancer Ovarian Cancer (9702G001) (9702G001) AR073 Ovarian Cancer Ovarian Cancer (9707G029) (9707G029) AR074 Ovarian Cancer Ovarian Cancer (9804G011) (9804G011) AR075 Ovarian Cancer Ovarian Cancer (9806G019) (9806G019) AR076 Ovarian Cancer Ovarian Cancer (9807G017) (9807G017) AR077 Ovarian Cancer Ovarian Cancer (9809G001) (9809G001) AR078 ovarian cancer 15799 ovarian cancer 15799 AR079 Ovarian Cancer Ovarian Cancer 17717AID 17717AID AR080 Ovarian Cancer Ovarian Cancer 4004664B1 4004664B1 AR081 Ovarian Cancer Ovarian Cancer 4005315A1 4005315A1 AR082 ovarian cancer 94127303 ovarian cancer 94127303 AR083 Ovarian Cancer 96069304 Ovarian Cancer 96069304 AR084 Ovarian Cancer 9707G029 Ovarian Cancer 9707G029 AR085 Ovarian Cancer 9807G045 Ovarian Cancer 9807G045 AR086 ovarian cancer 9809G001 ovarian cancer 9809G001 AR087 Ovarian Cancer Ovarian Cancer 9905C032RC 9905C032RC AR088 Ovarian cancer 9907 C00 Ovarian cancer 9907 3rd C00 3rd AR089 Prostate Prostate AR090 Prostate (clonetech) Prostate (clonetech) AR091 prostate cancer prostate cancer AR092 prostate cancer #15176 prostate cancer #15176 AR093 prostate cancer #15509 prostate cancer #15509 AR094 prostate cancer #15673 prostate cancer #15673 AR095 Small Intestine (Clontech) Small Intestine (Clontech) AR096 Spleen Spleen AR097 Thymus T cells activated Thymus T cells activated AR098 Thymus T cells resting Thymus T cells resting AR099 Tonsil Tonsil AR100 Tonsil germinal center Tonsil germinal centroblast center centroblast AR101 Tonsil germinal center B Tonsil germinal cell center B cell AR102 Tonsil lymph node Tonsil lymph node AR103 Tonsil memory B cell Tonsil memory B cell AR104 Whole Brain Whole Brain AR105 Xenograft ES-2 Xenograft ES-2 AR106 Xenograft SW626 Xenograft SW626 H0008 Whole 6 Week Old Uni-ZAP XR Embryo H0009 Human Fetal Brain Uni-ZAP XR H0012 Human Fetal Kidney Human Fetal Kidney Kidney Uni-ZAP XR H0013 Human 8 Week Whole Human 8 Week Old Embryo Uni-ZAP XR Embryo Embryo H0028 Human Old Ovary Human Old Ovary Ovary pBluescript H0030 Human Placenta Uni-ZAP XR H0031 Human Placenta Human Placenta Placenta Uni-ZAP XR H0032 Human Prostate Human Prostate Prostate Uni-ZAP XR H0038 Human Testes Human Testes Testis Uni-ZAP XR H0040 Human Testes Tumor Human Testes Testis disease Uni-ZAP XR Tumor H0046 Human Endometrial Human Endometrial Uterus disease Uni-ZAP XR Tumor Tumor H0050 Human Fetal Heart Human Fetal Heart Heart Uni-ZAP XR H0051 Human Hippocampus Human Brain Uni-ZAP XR Hippocampus H0052 Human Cerebellum Human Cerebellum Brain Uni-ZAP XR H0055 Human Umbilical Vein Human Umbilical Umbilical Uni-ZAP XR Vein Endothelial vein Cells H0056 Human Umbilical Vein, Human Umbilical Umbilical Uni-ZAP XR Endo. remake Vein Endothelial vein Cells H0057 Human Fetal Spleen Uni-ZAP XR H0059 Human Uterine Cancer Human Uterine Uterus disease Lambda Cancer ZAP II H0063 Human Thymus Human Thymus Thymus Uni-ZAP XR H0087 Human Thymus Human Thymus pBluescript H0090 Human T-Cell Lymphoma T-Cell Lymphoma T-Cell disease Uni-ZAP XR H0102 Human Whole 6 Week Human Whole Six Embryo pBluescript Old Embryo (II), subt Week Old Embryo H0111 Human Placenta, Human Placenta Placenta pBluescript subtracted H0124 Human Human Sk Muscle disease Uni-ZAP XR Rhabdomyosarcoma Rhabdomyosarcoma H0144 Nine Week Old Early 9 Wk Old Early Embryo Uni-ZAP XR Stage Human Stage Human H0150 Human Epididymus Epididymis Testis Uni-ZAP XR H0156 Human Adrenal Gland Human Adrenal Adrenal disease Uni-ZAP XR Tumor Gland Tumor Gland H0163 Human Synovium Human Synovium Synovium Uni-ZAP XR H0165 Human Prostate Cancer, Human Prostate Prostate disease Uni-ZAP XR Stage B2 Cancer, stage B2 H0166 Human Prostate Cancer, Human Prostate Prostate disease Uni-ZAP XR Stage B2 fraction Cancer, stage B2 H0168 Human Prostate Cancer, Human Prostate Prostate disease Uni-ZAP XR Stage C Cancer, stage C H0169 Human Prostate Cancer, Human Prostate Prostate disease Uni-ZAP XR Stage C fraction Cancer, stage C H0170 12 Week Old Early Stage Twelve Week Old Embryo Uni-ZAP XR Human Early Stage Human H0171 12 Week Old Early Stage Twelve Week Old Embryo Uni-ZAP XR Human, II Early Stage Human H0176 CAMA1Ee Cell Line CAMA1Ee Cell Breast Cell Line Uni-ZAP XR Line H0178 Human Fetal Brain Human Fetal Brain Brain Uni-ZAP XR H0179 Human Neutrophil Human Neutrophil Blood Cell Line Uni-ZAP XR H0181 Human Primary Breast Human Primary Breast disease Uni-ZAP XR Cancer Breast Cancer H0182 Human Primary Breast Human Primary Breast disease Uni-ZAP XR Cancer Breast Cancer H0188 Human Normal Breast Human Normal Breast Uni-ZAP XR Breast H0194 Human Cerebellum, Human Cerebellum Brain pBluescript subtracted H0196 Human Cardiomyopathy, Human Heart Uni-ZAP XR subtracted Cardiomyopathy H0211 Human Human Prostate Prostate pBluescript Prostate, differential expression H0212 Human Prostate, Human Prostate Prostate pBluescript subtracted H0244 Human 8 Week Whole Human 8 Week Old Embryo Uni-ZAP XR Embryo, subtracted Embryo H0252 Human Osteosarcoma Human Bone disease Uni-ZAP XR Osteosarcoma H0253 Human adult testis, large Human Adult Testis Testis Uni-ZAP XR inserts H0255 breast lymph node CDNA Breast Lymph Node Lymph Node Lambda library ZAP II H0263 human colon cancer Human Colon Colon disease Lambda Cancer ZAP II H0266 Human Microvascular HMEC Vein Cell Line Lambda Endothelial Cells, fract. A ZAP II H0270 HPAS (human pancreas, Human Pancreas Pancreas Uni-ZAP XR subtracted) H0271 Human Neutrophil, Human Neutrophil - Blood Cell Line Uni-ZAP XR Activated Activated H0294 Amniotic Cells - TNF Amniotic Cells - Placenta Cell Line Uni-ZAP XR induced TNF induced H0295 Amniotic Cells - Primary Amniotic Cells - Placenta Cell Line Uni-ZAP XR Culture Primary Culture H0310 human caudate nucleus Brain Brain Uni-ZAP XR H0316 HUMAN STOMACH Human Stomach Stomach Uni-ZAP XR H0328 human ovarian cancer Ovarian Cancer Ovary disease Uni-ZAP XR H0341 Bone Marrow Cell Line Bone Marrow Cell Bone Marrow Cell Line Uni-ZAP XR (RS4; 11) Line RS4; 11 H0369 H. Atrophic Endometrium Atrophic Uni-ZAP XR Endometrium and myometrium H0372 Human Testes Human Testes Testis pCMVSport 1 H0373 Human Heart Human Adult Heart Heart pCMVSport 1 H0383 Human Prostate BPH, re- Human Prostate Uni-ZAP XR excision BPH H0392 H. Meningima, M1 Human Meningima brain pSport1 H0399 Human Kidney Cortex, re- Human Kidney Lambda rescue Cortex ZAP II H0411 H Female Bladder, Adult Human Female Bladder pSport1 Adult Bladder H0412 Human umbilical vein HUVE Cells Umbilical Cell Line pSport1 endothelial cells, IL-4 vein induced H0414 Ovarian Tumor I, OV5232 Ovarian Tumor, Ovary disease pSport1 OV5232 H0415 H Ovarian Tumor, II, Ovarian Tumor, Ovary disease pCMVSport OV5232 OV5232 2.0 H0427 Human Adipose Human Adipose, left pSport1 hiplipoma H0428 Human Ovary Human Ovary Ovary pSport1 Tumor H0431 H. Kidney Medulla, re- Kidney medulla Kidney pBluescript excision H0435 Ovarian Tumor 10-3-95 Ovarian Tumor, Ovary pCMVSport OV350721 2.0 H0436 Resting T-Cell Library, II T-Cells Blood Cell Line pSport1 H0478 Salivary Gland, Lib 2 Human Salivary Salivary pSport1 Gland gland H0483 Breast Cancer cell line, Breast Cancer Cell pSport1 MDA 36 line, MDA 36 H0484 Breast Cancer Cell line, Breast Cancer Cell pSport1 angiogenic line, Angiogenic, 36T3 H0486 Hodgkin's Lymphoma II Hodgkin's disease pCMVSport Lymphoma II 2.0 H0494 Keratinocyte Keratinocyte pCMVSport 2.0 H0520 NTERA2 + retinoic acid, NTERA2, pSport1 14 days Teratocarcinoma cell line H0521 Primary Dendritic Cells, Primary Dendritic pCMVSport lib 1 cells 3.0 H0533 Human Stromal Human Stromal pSport1 endometrial fibroblasts, endometrial treated w/estradiol fibroblasts, treated wit H0534 Human Stromal Human Stromal pSport1 endometrial fibroblasts, endometrial treated with progesterone fibroblasts, treated w/ H0539 Pancreas Islet Cell Tumor Pancreas Islet Cell Pancreas disease pSport1 Tumour H0543 T cell helper II Helper T cell pCMVSport 3.0 H0544 Human endometrial Human endometrial pCMVSport stromal cells stromal cells 3.0 H0545 Human endometrial Human endometrial pCMVSport stromal cells-treated with stromal cells-treated 3.0 progesterone with proge H0546 Human endometrial Human endometrial pCMVSport stromal cells-treated with stromal cells-treated 3.0 estradiol with estra H0547 NTERA2 teratocarcinoma NTERA2, pSport1 cell line + retinoic acid (14 Teratocarcinoma days) cell line H0549 H. Epididiymus, caput & Human Uni-ZAP XR corpus Epididiymus, caput and corpus H0550 H. Epididiymus, cauda Human Uni-ZAP XR Epididiymus, cauda H0551 Human Thymus Stromal Human Thymus pCMVSport Cells Stromal Cells 3.0 H0553 Human Placenta Human Placenta pCMVSport 3.0 H0555 Rejected Kidney, lib 4 Human Rejected Kidney disease pCMVSport Kidney 3.0 H0560 KMH2 KMH2 pCMVSport 3.0 H0587 Healing groin wound; 7.5 Groin-2/19/97 groin disease pCMVSport hours post incision 3.0 H0592 Healing groin wound - HGS wound healing disease pCMVSport zero hr post-incision project; abdomen 3.0 (control) H0593 Olfactory Olfactory epithelium pCMVSport epithelium; nasalcavity from roof of left 3.0 nasal cacit H0596 Human Colon Cancer; re- Human Colon Colon Lambda excision Cancer ZAP II H0606 Human Primary Breast Human Primary Breast disease Uni-ZAP XR Cancer; re-excision Breast Cancer H0615 Human Ovarian Cancer Ovarian Cancer Ovary disease Uni-ZAP XR Reexcision H0616 Human Testes, Reexcision Human Testes Testis Uni-ZAP XR H0617 Human Primary Breast Human Primary Breast disease Uni-ZAP XR Cancer Reexcision Breast Cancer H0618 Human Adult Testes, Human Adult Testis Testis Uni-ZAP XR Large Inserts, Reexcision H0623 Human Umbilical Vein; Human Umbilical Umbilical Uni-ZAP XR Reexcision Vein Endothelial vein Cells H0632 Hepatocellular Tumor; re- Hepatocellular Liver Lambda excision Tumor ZAP II H0634 Human Testes Tumor, re- Human Testes Testis disease Uni-ZAP XR excision Tumor H0641 LPS activated derived LPS activated pSport1 dendritic cells monocyte derived dendritic cells H0643 Hep G2 Cells, PCR library Hep G2 Cells Other H0644 Human Placenta (re- Human Placenta Placenta Uni-ZAP XR excision) H0646 Lung, Cancer (4005313 Metastatic pSport1 A3): Invasive Poorly squamous cell lung Differentiated Lung carcinoma, poorly di Adenocarcinoma, H0647 Lung, Cancer (4005163 Invasive poorly disease pSport1 B7): Invasive, Poorly Diff. differentiated lung Adenocarcinoma, adenocarcinoma Metastatic H0648 Ovary, Cancer: (4004562 Papillary Cstic disease pSport1 B6) Papillary Serous neoplasm of low Cystic Neoplasm, Low malignant potentia Malignant Pot H0650 B-Cells B-Cells pCMVSport 3.0 H0651 Ovary, Normal: Normal Ovary pSport1 (9805C040R) H0657 B-cells (stimulated) B-cells (stimulated) pSport1 H0658 Ovary, Cancer 9809C332- Poorly Ovary & disease pSport1 (9809C332): Poorly differentiate Fallopian differentiated Tubes adenocarcinoma H0659 Ovary, Cancer Grade II Papillary Ovary disease pSport1 (15395A1F): Grade II Carcinoma, Ovary Papillary Carcinoma H0660 Ovary, Cancer: Poorly differentiated disease pSport1 (15799A1F) Poorly carcinoma, ovary differentiated carcinoma H0661 Breast, Cancer: (4004943 Breast cancer disease pSport1 A5) H0662 Breast, Normal: Normal Breast - Breast pSport1 (4005522B2) #4005522 (B2) H0663 Breast, Cancer: (4005522 Breast Cancer - Breast disease pSport1 A2) #4005522 (A2) H0664 Breast, Cancer: Breast Cancer Breast disease pSport1 (9806C012R) H0666 Ovary, Cancer: (4004332 Ovarian Cancer, disease pSport1 A2) Sample #4004332A2 H0670 Ovary, Cancer (4004650 Ovarian Cancer - pSport1 A3): Well-Differentiated 4004650A3 Micropapillary Serous Carcinoma H0672 Ovary, Cancer: (4004576 Ovarian Ovary pSport1 A8) Cancer (4004576A8) H0673 Human Prostate Cancer, Human Prostate Prostate Uni-ZAP XR Stage B2; re-excision Cancer, stage B2 H0674 Human Prostate Cancer, Human Prostate Prostate Uni-ZAP XR Stage C; re-excission Cancer, stage C H0676 Colon, Cancer: Colon Cancer pCMVSport (9808C064R)-total RNA 9808C064R 3.0 H0678 screened clones from Placenta Placenta Other placental library H0683 Ovarian Serous Papillary Serous papillary pCMVSport Adenocarcinoma adenocarcinoma, 3.0 stage 3C (9804G01 H0685 Adenocarcinoma of Adenocarcinoma of pCMVSport Ovary, Human Cell Line, Ovary, Human Cell 3.0 # OVCAR-3 Line, # OVCAR- H0686 Adenocarcinoma of Adenocarcinoma of pCMVSport Ovary, Human Cell Line Ovary, Human Cell 3.0 Line, # SW-626 H0687 Human normal Human normal Ovary pCMVSport ovary (#9610G215) ovary (#9610G215) 3.0 H0688 Human Ovarian Human Ovarian pCMVSport Cancer (#9807G017) cancer (#9807G017), 3.0 mRNA from Maura Ru H0689 Ovarian Cancer Ovarian Cancer, pCMVSport #9806G019 3.0 H0690 Ovarian Cancer, # Ovarian Cancer, pCMVSport 9702G001 #9702G001 3.0 S0004 Prostate Prostate BPH Prostate Lambda ZAP II S0013 Prostate Prostate prostate Uni-ZAP XR S0014 Kidney Cortex Kidney cortex Kidney Uni-ZAP XR S0026 Stromal cell TF274 stromal cell Bone marrow Cell Line Uni-ZAP XR S0028 Smooth muscle, control Smooth muscle Pulmanary Cell Line Uni-ZAP XR artery S0042 Testes Human Testes ZAP Express S0044 Prostate BPH prostate BPH Prostate disease Uni-ZAP XR S0052 neutrophils control human neutrophils blood Cell Line Uni-ZAP XR S0112 Hypothalamus Brain Uni-ZAP XR S0134 Apoptotic T-cell apoptotic cells Cell Line Uni-ZAP XR S0146 prostate-edited prostate BPH Prostate Uni-ZAP XR S0148 Normal Prostate Prostate prostate Uni-ZAP XR S0150 LNCAP prostate cell line LNCAP Cell Line Prostate Cell Line Uni-ZAP XR S0152 PC3 Prostate cell line PC3 prostate cell Uni-ZAP XR line S0168 Prostate/LNCAP, PC3 prostate cell pBluescript subtraction I line S0174 Prostate-BPH subtracted II Human Prostate pBluescript BPH S0176 Prostate, normal, Prostate prostate Uni-ZAP XR subtraction I S0188 Prostate, BPH, Lib 2 Human Prostate disease pSport1 BPH S0190 Prostate BPH, Lib 2, Human Prostate pSport1 subtracted BPH S0212 Bone Marrow Stromal Bone Marrow pSport1 Cell, untreated Stromal Cell, untreated S0222 H. Frontal H. Brain, Frontal Brain disease Uni-ZAP XR cortex, epileptic; re- Cortex, Epileptic excision S0242 Synovial Fibroblasts Synovial Fibroblasts pSport1 (I11/TNF), subt S0274 PCMIX PCMIX (Human Brain PCRII Cerebellum) S0282 Brain Frontal Cortex, re- Brain frontal cortex Brain Lambda excision ZAP II S0284 7TMCTT (Testis) 7TMCTP (Placenta) Testis PCRII S0286 7TMCTP (Placenta) H7MCTP Placenta PCRII (PLACENTA) S0294 Larynx tumor Larynx tumor Larynx, vocal disease pSport1 cord S0326 Mammary Gland Mammary Gland Whole pSport1 mammary gland S0328 Palate carcinoma Palate carcinoma Uvula disease pSport1 S0352 Larynx Carcinoma Larynx carcinoma disease pSport1 S0354 Colon Normal II Colon Normal Colon pSport1 S0358 Colon Normal III Colon Normal Colon pSport1 S0360 Colon Tumor II Colon Tumor Colon disease pSport1 S0374 Normal colon Normal colon pSport1 S0380 Pancreas Tumor PCA4 Tu Pancreas Tumor disease pSport1 PCA4 Tu S0396 Uterus; normal Uterus; normal pSport1 S0398 Testis; normal Testis; normal pSport1 S0412 Temporal cortex- Temporal cortex, disease Other Alzheizmer; subtracted alzheimer S0422 Mo7e Cell Line GM-CSF Mo7e Cell Line pCMVSport treated (1 ng/ml) GM-CSF treated 3.0 (1 ng/ml) S0424 TF-1 Cell Line GM-CSF TF-1 Cell Line pSport1 Treated GM-CSF Treated S0442 Colon Normal Colon Normal pSport1 S0444 Colon Tumor Colon Tumour disease pSport1 S0454 Placenta Placenta Placenta pSport1 S0456 Tongue Normal Tongue Normal pSport1 S0460 Thyroid Tumour Thyroid Tumour pSport1 T0010 Human Infant Brain Human Infant Brain Other T0041 Jurkat T-cell G1 phase Jurkat T-cell pBluescript SK− T0068 Normal Ovary, Normal Ovary, pBluescript Premenopausal Premenopausal SK− T0069 Human Uterus, normal Human Uterus, pBluescript normal SK− L0005 Clontech human aorta polyA+ mRNA (#6572) L002l Human adult (K. Okubo) L0023 human adult testis L0040 Human colon mucosa L0041 Human epidermal keratinocyte L0060 Human thymus NSTH II L0070 Selected chromosome 21 cDNA library L0109 Human brain cDNA brain L0142 Human placenta cDNA placenta (TFujiwara) L0143 Human placenta polyA+ placenta (TFujiwara) L0151 Human testis (C. De testis Smet) L0157 Human fetal brain brain (TFujiwara) L0163 Human heart cDNA heart (YNakamura) L0351 Infant brain, Bento Soares BA, M13- derived L0352 Normalized infant brain, BA, M13- Bento Soares derived L0361 Stratagene ovary ovary Bluescript (#937217) SK L0362 Stratagene ovarian cancer Bluescript (#937219) SK− L0363 NCI_CGAP_GC2 germ cell tumor Bluescript SK− L0365 NCI_CGAP_Phe1 pheochromocytoma Bluescript SK− L0366 Stratagene schizo brain schizophrenic brain Bluescript S11 S-11 frontal lobe SK− L0367 NCI_CGAP_Sch1 Schwannoma tumor Bluescript SK− L0369 NCI_CGAP_AA1 adrenal adenoma adrenal gland Bluescnpt SK− L0371 NCI_CGAP_Br3 breast tumor breast Bluescript SK− L0372 NCI_CGAP_Co12 colon tumor colon Bluescript SK− L0373 NCI_CGAP_Co11 tumor colon Bluescript SK− L0374 NCI_CGAP_Co2 tumor colon Bluescript SK− L0375 NCI_CGAP_Kid6 kidney tumor kidney Bluescript SK− L0376 NCI_CGAP_Lar1 larynx larynx Bluescript SK− L0378 NCI_CGAP_Lu1 lung tumor lung Bluescript SK− L0380 NCI_CGAP_HN1 squamous cell lymph node Bluescript carcinoma SK− L0381 NCI_CGAP_HN4 squamous cell pharynx Bluescript carcinoma SK− L0383 NCI_CGAP_Pr24 invasive tumor (cell prostate Bluescript line) SK− L0411 1-NIB Lafmid BA L0435 Infant brain, LLNL array lafmid BA of Dr. M. Soares 1NIB L0438 normalized infant brain total brain brain lafmid BA cDNA L0439 Soares infant brain 1NIB whole brain Lafmid BA L0441 2HB3MK Lafmid BK L0455 Human retina cDNA retina eye lambda gt10 randomly primed sublibrary L0462 WATM1 lambda gt11 L0465 TEST1, Human adult lambda Testis tissue nm1149 L0470 BL29 Burkitt's lambda ZAP lymphoma, Pascalis 2 Sideras L0471 Human fetal heart, Lambda Lambda ZAP Express ZAP Express L0475 KG1-a Lambda Zap KG1-a Lambda Zap Express cDNA library Express (Stratagene) L0480 Stratagene cat #937212 Lambda (1992) ZAP, pBluescript SK(−) L0483 Human pancreatic islet Lambda ZAPII L0485 STRATAGENE Human skeletal muscle leg muscle Lambda skeletal muscle cDNA ZAPII library, cat. #936215. L0492 Human Genomic pAMP L0509 NCI_CGAP_Lu26 invasive lung pAMP1 adenocarcinoma L0512 NCI_CGAP_Ov36 borderline ovarian ovary pAMP1 carcinoma L0513 NCI_CGAP_Ov37 early stage papillary ovary pAMP1 serous carcinoma L0515 NCI_CGAP_Ov32 papillary serous ovary pAMP1 carcinoma L0516 Chromosome 19p12-p13.1 pAMP10 exon L0517 NCI_CGAP_Pr1 pAMP10 L0518 NCI_CGAP_Pr2 pAMP10 L0519 NCI_CGAP_Pr3 pAMP10 L0520 NCI_CGAP_Alv1 alveolar pAMP10 rhabdomyosarcoma L0521 NCI_CGAP_Ew1 Ewing's sarcoma pAMP10 L0522 NCI_CGAP_Kid1 kidney pAMP10 L0523 NCI_CGAP_Lip2 liposarcoma pAMP10 L0524 NCI_CGAP_Li1 liver pAMP10 L0526 NCI_CGAP_Pr12 metastatic prostate pAMP10 bone lesion L0527 NCI_CGAP_Ov2 ovary pAMP10 L0528 NCI_CGAP_Pr5 prostate pAMP10 L0529 NCI_CGAP_Pr6 prostate pAMP10 L0532 NCI_CGAP_Thy1 thyroid pAMP10 L0533 NCI_CGAP_HSC1 stem cells bone marrow pAMP10 L0534 Chromosome 7 Fetal brain brain pAMP10 Brain cDNA Library L0536 NCI_CGAP_Br4 normal ductal tissue breast pAMP10 L0539 Chromosome 7 Placental placenta pAMP10 cDNA Library L0542 NCI_CGAP_Pr11 normal prostatic prostate pAMP10 epithelial cells L0547 NCI_CGAP_Pr16 tumor prostate pAMP10 L0558 NCI_CGAP_Ov40 endometrioid ovary pAMP10 ovarian metastasis L0565 Normal Human Bone Hip pBluescript Trabecular Bone Cells L0581 Stratagene liver (#937224) liver pBluescript SK L0586 HTCDL1 pBluescript SK(−) L0587 Stratagene colon HT29 pBluescript (#937221) SK− L0588 Stratagene endothelial cell pBluescript 937223 SK− L0589 Stratagene fetal retina pBluescript 937202 SK− L0590 Stratagene fibroblast pBluescript (#937212) SK− L0591 Stratagene HeLa cell s3 pBluescript 937216 SK− L0592 Stratagene hNT neuron pBluescript (#937233) SK− L0593 Stratagene pBluescript neuroepithelium SK− (#937231) L0594 Stratagene pBluescript neuroepithelium SK− NT2RAMI 937234 L0595 Stratagene NT2 neuronal neuroepithelial cells brain pBluescript precursor 937230 SK− L0596 Stratagene colon colon pBluescript (#937204) SK− L0597 Stratagene corneal stroma cornea pBluescript (#937222) SK− L0598 Morton Fetal Cochlea cochlea ear pBluescript SK− L0599 Stratagene lung (#937210) lung pBluescript SK− L0600 Weizmann Olfactory olfactory epithelium nose pBluescript Epithelium SK− L0601 Stratagene pancreas pancreas pBluescript (#937208) SK− L0602 Pancreatic Islet pancreatic islet pancreas pBluescript SK− L0603 Stratagene placenta placenta pBluescript (#937225) SK− L0604 Stratagene muscle 937209 muscle skeletal pBluescript muscle SK− L0605 Stratagene fetal spleen fetal spleen spleen pBluescript (#937205) SK− L0606 NCI_CGAP_Lym5 follicular lymphoma lymph node pBluescript SK− L0608 Stratagene lung carcinoma lung carcinoma lung NCI-H69 pBluescript 937218 SK− L0612 Schiller oligodendroglioma brain pBluescript oligodendroglioma SK− (Stratagene) L0617 Chromosome 22 exon pBluescriptII KS+ L0618 Chromosome 9 exon pBluescriptII KS+ L0623 HM3 pectoral muscle pcDNAII (after mastectomy) (Invitrogen) L0626 NCI_CGAP_GC1 bulk germ cell pCMV- seminoma SPORT2 L0635 NCI_CGAP_PNS1 dorsal root ganglion peripheral pCMV- nervous SPORT4 system L0637 NCI_CGAP_Brn53 three pooled brain pCMV- meningiomas SPORT6 L0638 NCI_CGAP_Brn35 tumor, 5 pooled (see brain pCMV- description) SPORT6 L0639 NCI_CGAP_Brn52 tumor, 5 pooled (see brain pCMV- description) SPORT6 L0642 NCI_CGAP_Co18 moderately colon pCMV- differentiated SPORT6 adenocarcinoma L0646 NCI_CGAP_Co14 moderately- colon pCMV- differentiated SPORT6 adenocarcinoma L0647 NCI_CGAP_Sar4 five pooled connective pCMV- sarcomas, including tissue SPORT6 myxoid liposarcoma L0649 NCI_CGAP_GU1 2 pooled high-grade genitourinary pCMV- transitional cell tract SPORT6 tumors L0655 NCI_CGAP_Lym12 lymphoma, lymph node pCMV- follicular mixed SPORT6 small and large cell L0656 NCI_CGAP_Ov38 normal epithelium ovary pCMV- SPORT6 L0657 NCI_CGAP_Ov23 tumor, 5 pooled (see ovary pCMV- description) SPORT6 L0658 NCI_CGAP_Ov35 tumor, 5 pooled (see ovary pCMV- description) SPORT6 L0659 NCI_CGAP_Pan1 adenocarcinoma pancreas pCMV- SPORT6 L0661 NCI_CGAP_Mel15 malignant skin pCMV- melanoma, SPORT6 metastatic to lymph node L0662 NCI_CGAP_Gas4 poorly differentiated stomach pCMV- adenocarcinoma SPORT6 with signet r L0663 NCI_CGAP_Ut2 moderately- uterus pCMV- differentiated SPORT6 endometrial adenocarcino L0664 NCI_CGAP_Ut3 poorly-differentiated uterus pCMV- endometrial SPORT6 adenocarcinoma, L0665 NCI_CGAP_Ut4 serous papillary uterus pCMV- carcinoma, high SPORT6 grade, 2 pooled t L0666 NCI_CGAP_Ut1 well-differentiated utereus pCMV- endometrial SPORT6 adenocarcinoma, 7 L0667 NCI_CGAP_CML1 myeloid cells, 18 whole blood pCMV- pooled CML cases, SPORT6 BCR/ABL rearra L0686 Stanley Frontal SN pool 2 frontal lobe (see brain pCR2.1- description) TOPO (Invitrogen) L0697 Testis 1 PGEM 5zf (+) L0698 Testis 2 PGEM 5zf (+) L0700 Outward Alu-primed pGEM-3Z hncDNA library L0717 Gessler Wilms tumor pSPORT1 L0731 Soares_pregnant_uterus_(—) uterus pT7T3-Pac NbHPU L0738 Human colorectal cancer pT7T3D L0740 Soares melanocyte melanocyte pT7T3D 2NbHM (Pharmacia) with a modified polylinker L0741 Soares adult brain brain pT7T3D N2b4HB55Y (Pharmacia) with a modified polylinker L0742 Soares adult brain brain pT7T3D N2b5HB55Y (Pharmacia) with a modified polylinker L0743 Soares breast 2NbHBst breast pT7T3D (Pharmacia) with a modified polylinker L0744 Soares breast 3NbHBst breast pT7T3D (Pharmacia) with a modified polylinker L0745 Soares retina N2b4HR retina eye pT7T3D (Pharmacia) with a modified polylinker L0746 Soares retina N2b5HR retina eye pT7T3D (Pharmacia) with a modified polylinker L0747 Soares_fetal_heart_NbHH heart pT7T3D 19W (Pharmacia) with a modified polylinker L0748 Soares fetal liver spleen Liver and pT7T3D 1NFLS Spleen (Pharmacia) with a modified polylinker L0749 Soares_fetal_liver_spleen Liver and pT7T3D _1NFLS_S1 Spleen (Pharmacia) with a modified polylinker L0750 Soares_fetal_lung_NbHL1 lung pT7T3D 9W (Pharmacia) with a modified polylinker L0751 Soares ovary tumor ovarian tumor ovary pT7T3D NbHOT (Pharmacia) with a modified polylinker L0752 Soares_parathyroid_tumor parathyroid tumor parathyroid pT7T3D _NbHPA gland (Pharmacia) with a modified polylinker L0753 Soares_pineal_gland_N3H pineal gland pT7T3D PG (Pharmacia) with a modified polylinker L0754 Soares placenta Nb2HP placenta pT7T3D (Pharmacia) with a modified polylinker L0755 Soares_placenta_8to9wee placenta pT7T3D ks_2NbHP8to9W (Pharmacia) with a modified polylinker L0756 Soares_multiple_sclerosis multiple sclerosis pT7T3D _2NbHMSP lesions (Pharmacia) with a modified polylinker V_TYPE L0757 Soares_senescent_fibrobla senescent fibroblast pT7T3D sts_NbHSF (Pharmacia) with a modified polylinker V_TYPE L0758 Soares_testis_NHT pT7T3D-Pac (Pharmacia) with a modified polylinker L0759 Soares_total_fetus_Nb2H pT7T3D-Pac F8_9w (Pharmacia) with a modified polylinker L0761 NCI_CGAP_CLL1 B-cell, chronic pT7T3D-Pac lymphotic leukemia (Pharmacia) with a modified polylinker L0762 NCI_CGAP_Br1.1 breast pT7T3D-Pac (Pharmacia) with a modified polylinker L0763 NCI_CGAP_Br2 breast pT7T3D-Pac (Pharmacia) with a modified polylinker L0764 NCI_CGAP_Co3 colon pT7T3D-Pac (Pharmacia) with a modified polylinker L0765 NCI_CGAP_Co4 colon pT7T3D-Pac (Pharmacia) with a modified polylinker L0766 NCI_CGAP_GCB1 germinal center B pT7T3D-Pac cell (Pharmacia) with a modified polylinker L0767 NCI_CGAP_GC3 pooled germ cell pT7T3D-Pac tumors (Pharmacia) with a modified polylinker L0768 NCI_CGAP_GC4 pooled germ cell pT7T3D-Pac tumors (Pharmacia) with a modified polylinker L0769 NCI_CGAP_Brn25 anaplastic brain pT7T3D-Pac oligodendroglioma (Pharmacia) with a modified polylinker L0770 NCI_CGAP_Brn23 glioblastoma brain pT7T3D-Pac (pooled) (Pharmacia) with a modified polylinker L0771 NCI_CGAP_Co8 adenocarcinoma colon pT7T3D-Pac (Pharmacia) with a modified polylinker L0772 NCI_CGAP_Co10 colon tumor RER− colon pT7T3D-Pac (Pharmacia) with a modified polylinker L0773 NCI_CGAP_Co9 colon tumor RER+ colon pT7T3D-Pac (Pharmacia) with a modified polylinker L0774 NCI_CGAP_Kid3 kidney pT7T3D-Pac (Pharmacia) with a modified polylinker L0775 NCI_CGAP_Kid5 2 pooled tumors kidney pT7T3D-Pac (clear cell type) (Pharmacia) with a modified polylinker L0776 NCI_CGAP_Lu5 carcinoid lung pT7T3D-Pac (Pharmacia) with a modified polylinker L0777 Soares_NhHMPu_S1 Pooled human mixed (see pT7T3D-Pac melanocyte, fetal below) (Pharmacia) heart, and pregnant with a modified polylinker L0779 Soares_NFL_T_GBC_S1 pooled p7P7T3D-Pac (Pharmacia) with a modified polylinker L0780 Soares_NSF_F8_9W_OT pooled pT7T3D-Pac _PA_P_S1 (Pharmacia) with a modified polylinker L0782 NCI_CGAP_Pr21 normal prostate prostate pT7T3D-Pac (Pharmacia) with a modified polylinker L0783 NCI_CGAP_Pr22 normal prostate prostate pT7T3D-Pac (Pharmacia) with a modified polylinker L0786 Soares_NbHFB whole brain pT7T3D-Pac (Pharmacia) with a modified polylinker L0787 NCI_CGAP_Sub1 pT7T3D-Pac (Pharmacia) with a modified polylinker L0788 NCI_CGAP_Sub2 pT7T3D-Pac (Pharmacia) with a modified polylinker L0789 NCI_CGAP_Sub3 pT7T3D-Pac (Pharmacia) with a modified polylinker L0790 NCI_CGAP_Sub4 pT7T3D-Pac (Pharmacia) with a modified polylinker L0791 NCI_CGAP_Sub5 pT7T3D-Pac (Pharmacia) with a modified polylinker L0792 NCI_CGAP_Sub6 pT7T3D-Pac (Pharmacia) with a modified polylinker L0794 NCI_CGAP_GC6 pooled germ cell pT7T3D-Pac tumors (Pharmacia) with a modified polylinker L0796 NCI_CGAP_Brn50 medulloblastoma brain pT7T3D-Pac (Pharmacia) with a modified polylinker L0800 NCI_CGAP_Co16 colon tumor, RER+ colon pT7T3D-Pac (Pharmacia) with a modified polylinker L0803 NCI_CGAP_Kid11 kidney pT7T3D-Pac (Pharmacia) with a modified polylinker L0804 NCI_CGAP_Kid12 2 pooled tumors kidney pT7T3D-Pac (clear cell type) (Pharmacia) with a modified polylinker L0805 NCI_CGAP_Lu24 carcinoid lung pT7T3D-Pac (Pharmacia) with a modified polylinker L0806 NCI_CGAP_Lu19 squamous cell lung pT7T3D-Pac carcinoma, poorly (Pharmacia) differentiated (4 with a modified polylinker L0807 NCI_CGAP_Ov18 fibrotheoma ovary pT7T3D-Pac (Pharmacia) with a modified polylinker L0809 NCI_CGAP_Pr28 prostate pT7T3D-Pac (Pharmacia) with a modified polylinker

[0129] TABLE 5 OMIM Reference Description 102200 Somatotrophinoma 102480 Male infertility due to acrosin deficiency 102770 Myoadenylate deaminase deficiency 103050 Autism, succinylpurinemic 103050 Adenylosuccinase deficiency 104770 Amyloidosis, secondary, susceptibility to 106100 Angioedema, hereditary 106150 Hypertension, essential, susceptibility to 106150 Preeclampsia, susceptibility to 106300 Ankylosing spondylitis 107670 Apolipoprotein A-II deficiency 107741 Hyperlipoproteinemia, type III 107910 Virilization, maternal and fetal, from placental aromatase deficiency 107910 Gynecomastia, familial, due to increased aromatase activity 108725 Atherosclerosis, susceptibility to 108800 Atrial septal defect, secundum type 108962 Hypertension, salt-resistant 109270 Renal tubular acidosis, distal, 179800 109270 Spherocytosis, hereditary 109270 [Acanthocytosis, one form] 109270 [Elliptocytosis, Malaysian-Melanesian type] 109270 Hemolytic anemia due to band 3 defect 109400 Basal cell nevus syndrome 109700 Hemodialysis-related amyloidosis 110700 Vivax malaria, susceptibility to 113100 Brachydactyly, type C 113705 Ovarian cancer 113705 Breast cancer-1 113721 Breast cancer 113900 Heart block, progressive familial, type I 114240 Muscular dystrophy, limb-girdle, type 2A, 253600 116806 Colorectal cancer 118485 Polycystic ovary syndrome with hyperandrogenemia 118504 Epilepsy, benign neonatal, type 1, 121200 118504 Epilepsy, nocturnal frontal lobe, 600513 118800 Choreoathetosis, familial paroxysmal 120110 Metaphyseal chondrodysplasia, Schmid type 120120 Epidermolysis bullosa dystrophica, dominant, 131750 120120 Epidermolysis bullosa dystrophica, recessive, 226600 120120 Epidermolysis bullosa, pretibial, 131850 120215 Ehlers-Danlos syndrome, type I, 130000 120215 Ehlers-Danlos syndrome, type II, 130010 120280 Stickler syndrome, type III 120280 Marshall syndrome, 154780 120290 OSMED syndrome, 215150 120290 Stickler syndrome, type II, 184840 120435 Muir-Torre syndrome, 158320 120435 Colorectal cancer, hereditary, nonpolyposis, type 1 Ovarian cancer 120436 Muir-Torre family cancer syndrome, 158320 120436 Turcot syndrome with glioblastoma, 276300 120436 Colorectal cancer, hereditary nonpolyposis, type 2 120700 C3 deficiency 120810 C4 deficiency 120820 C4 deficiency 120940 C9 deficiency 121011 Deafness, autosomal dominant 3, 601544 121011 Deafness, autosomal recessive 1, 220290 121014 Heterotaxia, visceroatrial, autosomal recessive 122720 Nicotine addiction, protection from 122720 Coumarin resistance, 122700 123620 Cataract, cerulean, type 2, 601547 123660 Cataract, Coppock-like 124030 Parkinsonism, susceptibility to 124030 Debrisoquine sensitivity 124200 Darier disease (keratosis follicularis) 125270 Porphyria, acute hepatic 125270 Lead poisoning, susceptibility to 125660 Myopathy, desminopathic 125660 Cardiomyopathy 125852 Insulin-dependent diabetes mellitus-2 126340 Xeroderma pigmentosum, group D, 278730 126391 DNA ligase I deficiency 126452 Autonomic nervous system dysfunction 126452 [Novelty seeking personality] 126600 Drusen, radial, autosomal dominant 126650 Chloride diarrhea, congenital, Finnish type, 214700 126650 Colon cancer 128100 Dystonia-1, torsion 129500 Ectodermal dysplasia, hidrotic 130410 Glutaricaciduria, type IIB 131100 Multiple endocrine neoplasia I 131100 Prolactinoma, hyperparathyroidism, carcinoid syndrome 131100 Carcinoid tumor of lung 131242 Shah-Waardenburg syndrome, 277580 132800 Basal cell carcinoma 132800 Epithelioma, self-healing, squamous 1, Ferguson-Smith type 133171 [Erythrocytosis, familial], 133100 133450 Neuroepithelioma 133450 Ewing sarcoma 133701 Exostoses, multiple, type 2 133780 Vitreoretinopathy, exudative, familial 134580 Factor XIIIB deficiency 134790 Hyperferritinemia-cataract syndrome, 600886 134797 Shprintzen-Goldberg syndrome, 182212 134797 Ectopia lentis, isolated 134797 Marfan syndrome, 154700 135300 Fibromatosis, gingival 135940 Ichthyosis vulgaris, 146700 136350 Pfeiffer syndrome, 101600 136435 Ovarian dysgenesis, hypergonadotropic, with normal karyotype, 233300 136550 Macular dystrophy, North Carolina type 136836 Fucosyltransferase-6 deficiency 137350 Amyloidosis, Finnish type, 105120 138079 Hyperinsulinism, familial, 602485 138079 MODY, type 2, 125851 138320 Hemolytic anemia due to glutathione peroxidase deficiency 138570 Non-insulin dependent diabetes mellitus, susceptibility to 138720 Bernard-Soulier syndrome, type B 138981 Pulmonary alveolar proteinosis, 265120 139191 Growth hormone deficient dwarfism 139320 Pituitary ACTH secreting adenoma 139320 Pseudohypoparathyroidism, type Ia, 103580 139320 Somatotrophinoma 139320 McCune-Albright polyostotic fibrous dysplasia, 174800 141750 Alpha-thalassemia/mental retardation syndrome, type 1 141800 Methemoglobinemias, alpha- 141800 Thalassemias, alpha- 141800 Erythremias, alpha- 141800 Heinz body anemias, alpha- 141850 Thalassemia, alpha- 141850 Erythrocytosis 141850 Heinz body anemia 141850 Hemoglobin H disease 141850 Hypochromic microcytic anemia 141900 Methemoglobinemias, beta- 141900 Sickle cell anemia 141900 Thalassemias, beta- 141900 Erythremias, beta- 141900 HPFH, deletion type 141900 Heinz body anemias, beta- 142000 Thalassemia due to Hb Lepore 142000 Thalassemia, delta- 142200 HPFH, nondeletion type A 142250 HPFH, nondeletion type G 142270 Hereditary persistence of fetal hemoglobin 142470 [Hereditary persistence of fetal hemoglobin, heterocellular] 142857 Pemphigoid, susceptibility to 142858 Beryllium disease, chronic, susceptibility to 142959 Hand-foot-uterus syndrome, 140000 143890 Hypercholesterolemia, familial 144200 Epidermolytic palmoplantar keratoderma 145001 Hyperparathyroidism-jaw tumor syndrome 145260 Pseudohypoaldosteronism, type II 145410 Opitz G syndrome, type II 145981 Hypocalciuric hypercalcemia, type II 146760 [IgG receptor I, phagocytic, familial deficiency of] 146790 Lupus nephritis, susceptibility to 147050 Atopy 147141 Leukemia, acute lymphoblastic 147200 [Kappa light chain deficiency] 147440 Growth retardation with deafness and mental retardation 147670 Rabson-Mendenhall syndrome 147670 Diabetes mellitus, insulin-resistant, with acanthosis nigricans 147670 Leprechaunism 148065 White sponge nevus, 193900 148066 Epidermolysis bullosa simplex, Koebner, Dowling-Meara, and Weber-Cockayne types, 131900, 131760, 131800 148066 Epidermolysis bullosa simplex, recessive, 601001 148067 Nonepidermolytic palmoplantar keratoderma, 600962 148067 Pachyonychia congenita, Jadassohn-Lewandowsky type, 167200 148069 Pachyonychia congenita, Jackson-Lawler type, 167210 148080 Epidermolytic hyperkeratosis, 113800 150270 Laryngeal adductor paralysis 151400 Leukemia/lymphoma, B-cell, 1 151440 Leukemia, T-cell acute lymphoblastoid 151670 Hepatic lipase deficiency 152200 Coronary artery disease, susceptibility to 152445 Vohwinkel syndrome, 124500 152445 Erythrokeratoderma, progressive symmetric, 602036 152760 Hypogonadotropic hypogonadism due to GNRH deficiency, 227200 152790 Precocious puberty, male, 176410 152790 Leydig cell hypoplasia 153700 Macular dystrophy, vitelliform type 153880 Macular dystrophy, dominant cystoid 154275 Malignant hyperthermia susceptibility 2 154276 Malignant hyperthermia susceptibility 3 155555 [Red hair/fair skin] 155555 UV-induced skin damage, vulnerability to 156225 Muscular dystrophy, congenital merosin-deficient 156850 Cataract, congenital, with microphthalmia 157170 Holoprosencephaly-2 158590 Spinal muscular atrophy-4 159001 Muscular dystrophy, limb-girdle, type 1B 160781 Cardiomyopathy, hypertrophic, mid-left ventricular chamber type 160900 Myotonic dystrophy 161015 Mitochondrial complex I deficiency, 252010 163950 Noonan syndrome-1 163950 Cardiofaciocutaneous syndrome, 115150 164009 Leukemia, acute promyelocytic, NUMA/RARA type 164200 Oculodentodigital dysplasia 164200 Syndactyly, type III, 186100 164731 Ovarian carcinoma, 167000 164953 Liposarcoma 166600 Osteopetrosis, AD, type II 167000 Ovarian cancer, serous 167250 Paget disease of bone 168461 Multiple myeloma, 254250 168461 Parathyroid adenomatosis 1 168461 Centrocytic lymphoma 168468 Metaphyseal chondrodysplasia, Murk Jansen type, 156400 168500 Parietal foramina 168610 Parkinsonism-dementia with pallidopontonigral degeneration 170261 Bare lymphocyte syndrome, type I, due to TAP2 deficiency 170995 Zellweger syndrome-2 171190 Hypertension, essential, 145500 171650 Lysosomal acid phosphatase deficiency 172400 Hemolytic anemia due to glucosephosphate isomerase deficiency 172400 Hydrops fetalis, one form 173360 Thrombophilia due to excessive plasminogen activator inhibitor 173360 Hemorrhagic diathesis due to PAI1 deficiency 173370 Plasminogen activator deficiency 173850 Polio, susceptibility to 173870 Xeroderma pigmentosum 173870 Fanconi anemia 174000 Medullary cystic kidney disease, AD 176705 Breast cancer, sporadic 176730 Diabetes mellitus, rare form 176730 Hyperproinsulinemia, familial 176730 MODY, one form 176930 Dysprothrombinemia 176930 Hypoprothrombinemia 177900 Psoriasis susceptibility-1 178640 Pulmonary alveolar proteinosis, congenital, 265120 179450 Ragweed sensitivity 179605 Retinitis pigmentosa, digenic 179605 Retinitis pigmentosa-7, peripherin-related 179605 Retinitis punctata albescens 179605 Butterfly dystrophy, retinal 179605 Macular dystrophy 179755 Renal cell carcinoma, papillary, 1 180020 Retinal cone dystrophy-1 180100 Retinitis pigmentosa-1 180104 Retinitis pigmentosa-9 180297 Anemia, hemolytic, Rh-null, suppressor type, 268150 180721 Retinitis pigmentosa, digenic 180840 Susceptibility to IDDM 180901 Malignant hyperthermia susceptibility 1, 145600 180901 Central core disease, 117000 181430 Scapuloperoneal syndrome, myopathic type 182280 Small-cell cancer of lung 182380 Glucose/galactose malabsorption 182601 Spastic paraplegia-4 182860 Pyropoikilocytosis 182860 Spherocytosis, recessive 182860 Elliptocytosis-2 182900 Spherocytosis-2 185430 Atherosclerosis, susceptibility to 185800 Symphalangism, proximal 186580 Arthrocutaneouveal granulomatosis 186855 Leukemia-2, T-cell acute lymphoblastic 188070 Bleeding disorder due to defective thromboxane A2 receptor 188540 Hypothyroidism, nongoitrous 188826 Sorsby fundus dystrophy, 136900 189800 Preeclampsia/eclampsia 190020 Bladder cancer, 109800 190040 Dermatofibrosarcoma protuberans 190040 Giant-cell fibroblastoma 190040 Meningioma, SIS-related 190182 Colon cancer 190182 Colorectal cancer, familial nonpolyposis, type 6 190198 Leukemia, T-cell acute lymphoblastic 191092 Tuberous sclerosis-2 191100 Tuberous sclerosis-1 191170 Colorectal cancer, 114500 191170 Li-Fraumeni syndrome 191181 Cervical carcinoma 191290 Segawa syndrome, recessive 191315 Insensitivity to pain, congenital, with anhidrosis, 256800 192500 Jervell and Lange-Nielsen syndrome, 220400 192500 Long QT syndrome-1 193235 Vitreoretinopathy, neovascular inflammatory 193500 Rhabdomyosarcoma, alveolar, 268220 193500 Waardenburg syndrome, type I 193500 Waardenburg syndrome, type III, 148820 193500 Craniofacial-deafness-hand syndrome, 122880 194071 Wilms tumor, type 2 194071 Adrenocortical carcinoma, hereditary, 202300 200350 Acetyl-CoA carboxylase deficiency 201460 Acyl-CoA dehydrogenase, long chain, deficiency of 201910 Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 204500 Ceroid-lipofuscinosis, neuronal 2, classic late infantile 205100 Amyotrophic lateral sclerosis, juvenile 207750 Hyperlipoproteinemia, type Ib 209901 Bardet-Biedl syndrome 1 215700 Citrullinemia 216900 Achromatopsia 217000 C2 deficiency 217050 C6 deficiency 217050 Combined C6/C7 deficiency 217070 C7 deficiency 221770 Polycystic lipomembranous osteodysplasia with sclerosing leukencephalopathy 221820 Gliosis, familial progressive subcortical 222100 Diabetes mellitus, insulin-dependent-1 223360 Dopamine-beta-hydroxylase deficiency 223900 Dysautonomia, familial 227646 Fanconi anemia, type D 227650 Fanconi anemia, type A 230400 Galactosemia 230450 Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency 230800 Gaucher disease 230800 Gaucher disease with cardiovascular calcification 231670 Glutaricaciduria, type I 231680 Glutaricaciduria, type IIA 231950 Glutathioninuria 232200 Glycogen storage disease I 232400 Glycogen storage disease IIIa 232400 Glycogen storage disease IIIb 232600 McArdle disease 232800 Glycogen storage disease VII 233100 [Renal glucosuria] 235200 Hemochromatosis 237300 Carbamoylphosphate synthetase I deficiency 239500 Hyperprolinemia, type I 245050 Ketoacidosis due to SCOT deficiency 247200 Miller-Dieker lissencephaly syndrome 248600 Maple syrup urine disease, type Ia 248611 Maple syrup urine disease, type Ib 249000 Meckel syndrome 250250 Cartilage-hair hypoplasia 251170 Mevalonicaciduria 252920 Sanfilippo syndrome, type B 253000 Mucopolysaccharidosis IVA 253250 Mulibrey nanism 253700 Muscular dystrophy, limb-girdle, type 2C 253800 Walker-Warburg syndrome, 236670 253800 Fukuyama type congenital muscular dystrophy 256540 Galactosialidosis 256550 Sialidosis, type I 256550 Sialidosis, type II 256850 Giant axonal neuropathy-1 258501 3-methylglutaconicaciduria, type III 259700 Osteopetrosis, recessive 259770 Osteoporosis-pseudoglioma syndrome 261510 Pseudo-Zellweger syndrome 262000 Bjornstad syndrome 263200 Polycystic kidney disease, autosomal recessive 266200 Anemia, hemolytic, due to PK deficiency 268900 [Sarcosinemia] 270800 Spastic paraplegia-5A 272800 Tay-Sachs disease 272800 [Hex A pseudodeficiency] 272800 GM2-gangliosidosis, juvenile, adult 275350 Transcobalamin II deficiency 276700 Tyrosinemia, type I 276710 Tyrosinemia, type III 277700 Werner syndrome 278300 Xanthinuria, type I 278700 Xeroderma pigmentosum, group A 300000 Opitz G syndrome, type I 300066 Deafness, X-linked 6, sensorineural 300067 Subcortical laminar heterotopia, X-linked dominant 300067 Lissencephaly, X-linked 300077 Mental retardation, X-linked 29 300121 Subcortical laminal heteropia, X-linked, 300067 300121 Lissencephaly, X-linked, 300067 300123 Mental retardation with isolated growth hormone deficiency 300310 Agammaglobulinemia, type 2, X-linked 300500 Ocular albinism, Nettleship-Falls type 300650 Ocular albinism with sensorineural deafness 301200 Amelogenesis imperfecta 301201 Amelogenesis imperfecta-3, hypoplastic type 301220 Partington syndrome II 301835 Arts syndrome 301845 Bazex syndrome 301900 Borjeson-Forssman-Lehmann syndrome 302350 Nance-Horan syndrome 302950 Chondrodysplasia punctata, X-linked recessive, 302940 304050 Aicardi syndrome 304110 Craniofrontonasal dysplasia 304340 Mental retardation, X-linked, syndromic-5, with Dandy- Walker malformation, basal ganglia disease, and seizures 306100 Gonadal dysgenesis, XY female type 307150 Hypertrichosis, congenital generalized 307700 Hypoparathyroidism, X-linked 308000 HPRT-related gout 308000 Lesch-Nyhan syndrome 308700 Kallmann syndrome 309000 Lowe syndrome 309530 Mental retardation, X-linked 1, non-dysmorphic 309585 Mental retardation, X-linked, syndromic-6, with gynecomastia and obesity 310490 Cowchock syndrome 311200 Oral-facial-digital syndrome 1 311850 Phosphoribosyl pyrophosphate synthetase-related gout 312040 N syndrome, 310465 313850 Thoracoabdominal syndrome 600040 Colorectal cancer 600045 Xeroderma pigmentosum, group E, subtype 2 600059 Retinitis pigmentosa-13 600105 Retinitis pigmentosa-12, autosomal recessive 600119 Muscular dystrophy, Duchenne-like, type 2 600119 Adhalinopathy, primary 600140 Rubenstein-Taybi syndrome, 180849 600163 Long QT syndrome-3 600175 Spinal muscular atrophy, congenital nonprogressive, of lower limbs 600202 Dyslexia, specific, 2 600234 HMG-CoA synthease-2 deficiency 600261 Ehlers-Danlos-like syndrome 600266 Resistance/susceptibility to TB, etc. 600273 Polycystic kidney disease, infantile severe, with tuberous sclerosis 600276 Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, 125310 600281 Non-insulin-dependent diabetes mellitus, 125853 600281 MODY, type 1, 125850 600309 Atrioventricular canal defect-1 600319 Diabetes mellitus, insulin-dependent, 4 600320 Insulin-dependent diabetes mellitus-5 600364 Cone dystrophy-3, 602093 600374 Bardet-Biedl syndrome 4 600528 CPT deficiency, hepatic, type I, 255120 600617 Lipoid adrenal hyperplasia, 201710 600623 Prostate cancer, 176807 600759 Alzheimer disease-4 600808 Enuresis, nocturnal, 2 600811 Xeroderma pigmentosum, group E, DDB-negative subtype, 278740 600837 Hirschsprung disease, 142623 600839 Bartter syndrome, 241200 600850 Schizophrenia disorder-4 600856 Beckwith-Wiedemann syndrome, 130650 600883 Diabetes mellitus, insulin-dependent, 8 600897 Cataract, zonular pulverulent-1, 116200 600918 Cystinuria, type III 600946 Short stature, autosomal dominant, with normal serum growth hormone binding protein 600946 Short stature, idiopathic 600946 Laron dwarfism, 262500 600957 Persistent Mullerian duct syndrome, type I, 261550 600958 Cardiomyopathy, familial hypertrophic, 4, 115197 600964 Refsum disease, adult, with increased pipecolicacidemia 600983 Pseudohypoaldosteronism type I, autosomal dominant, 177735 600994 Deafness, autosomal dominant 5 600996 Arrhythmogenic right ventricular dysplasia-2 601071 Deafness, autosomal recessive 9 601105 Pycnodysostosis, 265800 601154 Cardiomyopathy, dilated, 1E 601238 Cerebellar ataxia, Cayman type 601277 Ichthyosis, lamellar, type 2 601284 Hereditary hemorrhagic telangiectasia-2, 600376 601313 Polycystic kidney disease, adult type I, 173900 601316 Deafness, autosomal dominant 10 601362 DiGeorge syndrome/velocardiofacial syndrome complex-2 601363 Wilms tumor, type 4 601410 Diabetes mellitus, transient neonatal 601412 Deafness, autosomal dominant 7 601414 Retinitis pigmentosa-18 601498 Peroxisomal biogenesis disorder, complementation group 4 601517 Spinocerebellar ataxia-2, 183090 601545 Lissencephaly-1 601649 Blepharophimosis, epicanthus inversus, and ptosis, type 2 601652 Glaucoma 1A, primary open angle, juvenile-onset, 137750 601666 Insulin-dependent diabetes mellitus-15 601669 Hirschsprung disease, one form 601680 Distal arthrogryposis, type 2B 601690 Platelet-activating factor acetylhydrolase deficiency 601691 Retinitis pigmentosa-19, 601718 601691 Stargardt disease-1, 248200 601691 Cone-rod dystrophy 3 601691 Fundus flavimaculatus with macular dystrophy, 248200 601718 Retinitis pigmentosa-19 601744 Systemic lupus erythematosus, susceptibility to, 1 601757 Rhizomelic chondrodysplasia punctata, type 1, 215100 601769 Osteoporosis, involutional 601769 Rickets, vitamin D-resistant, 277440 601771 Glaucoma 3A, primary infantile, 231300 601780 Ceroid-lipofuscinosis, neuronal-6, variant late infantile 601785 Carbohydrate-deficient glycoprotein syndrome, type I, 212065 601843 Hypothyroidism, congenital, 274400 601844 Pseudohypoaldosteronism type II 601846 Muscular dystrophy with rimmed vacuoles 601850 Retinitis pigmentosa-deafness syndrome 601863 Bare lymphocyte syndrome, complementation group C 601868 Deafness, autosomal dominant 13 601884 [High bone mass] 601885 Cataract, zonular pulverulent-2 601975 Ectodermal dysplasia/skin fragility syndrome 602025 Obesity/hyperinsulinism, susceptibility to 602026 Refsum disease, 266500 602078 Fibrosis of extraocular muscles, congenital, 2 602088 Nephronophthisis, infantile 602094 Lipodystrophy, familial partial 602099 Amytrophic lateral sclerosis-5 602116 Glioma 602134 Tremor, familial essential, 2 602136 Refsum disease, infantile, 266510 602136 Zellweger syndrome-1, 214100 602136 Adrenoleukodystrophy, neonatal, 202370 602216 Peutz-Jeghers syndrome, 175200 602221 Stem-cell leukemia/lymphoma syndrome 602225 Cone-rod retinal dystrophy-2, 120970 602225 Leber congenital amaurosis, type III 602229 Waardenburg-Shah syndrome, 277580 602235 Epilepsy, benign, neonatal, type 1, 121200 602280 Retinitis pigmentosa-14, 600132 602447 Coronary artery disease, susceptibility to 602475 Ossification of posterior longitudinal ligament of spine 602477 Febrile convulsions, familial, 2 602491 Hyperlipidemia, familial combined, 1 602544 Parkinson disease, juvenile, type 2, 600116 602631 Rhabdomyosarcoma, 268210 602631 Breast Cancer 602716 Nephrosis-1, congenital, Finnish type, 256300 602772 Retinitis pitmentosa-24 602782 Faisalabad histiocytosis 602783 Spastic paraplegia-7

[0130] Polynucleotide and Polypeptide Variants

[0131] The present invention is also directed to variants of the reproductive system associted polynucleotide sequence disclosed in SEQ ID NO: X or the complementary strand thereto, nucleotide sequences encoding the polypeptide of SEQ ID NO: Y, the nucleotide sequence of SEQ ID NO: X encoding the polypeptide sequence as defined in column 6 of Table 1A, nucleotide sequences encoding the polypeptide as defined in column 6 of Table 1A, the nucleotide sequence as defined in columns 8 and 9 of Table 2, nucleotide sequences encoding the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2, the nucleotide sequence as defined in column 6 of Table 1B, nucleotide sequences encoding the polypeptide encoded by the nucleotide sequence as defined in column 6 of Table 1B, the cDNA sequence contained in Clone ID NO: Z, and/or nucleotide sequences encoding a polypeptide encoded by the cDNA sequence contained in Clone ID NO :Z.

[0132] The present invention also encompasses variants of the polypeptide sequence disclosed in SEQ ID NO: Y, a polypeptide sequence as defined in column 6 of Table 1A, a polypeptide sequence encoded by the polynucleotide sequence in SEQ ID NO: X, a polypeptide sequence encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2, a polypeptide sequence encoded by the nucleotide sequence as defined in column 6 of Table 1B, a polypeptide sequence encoded by the complement of the polynucleotide sequence in SEQ ID NO: X, and/or a polypeptide sequence encoded by the cDNA sequence contained in Clone ID NO: Z.

[0133] “Variant” refers to a polynucleotide or polypeptide differing from the polynucleotide or polypeptide of the present invention, but retaining essential properties thereof. Generally, variants are overall closely similar, and, in many regions, identical to the polynucleotide or polypeptide of the present invention.

[0134] Thus, one aspect of the invention provides an isolated nucleic acid molecule comprising, or alternatively consisting of, a polynucleotide having a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence described in SEQ ID NO: X or contained in the cDNA sequence of Clone ID NO: Z; (b) a nucleotide sequence in SEQ ID NO: X or the cDNA in Clone ID NO: Z which encodes a mature reproductive system associated polypeptide; (c) a nucleotide sequence in SEQ ID NO: X or the cDNA sequence of Clone ID NO: Z, which encodes a biologically active fragment of a reproductive system associated polypeptide; (d) a nucleotide sequence in SEQ ID NO: X or the cDNA sequence of Clone ID NO: Z, which encodes an antigenic fragment of a reproductive system associated polypeptide; (e) a nucleotide sequence encoding a reproductive system associated polypeptide having the complete amino acid sequence of SEQ ID NO: Y or the complete amino acid sequence encoded by the cDNA in Clone ID NO: Z; (f) a nucleotide sequence encoding a mature reproductive system associated polypeptide of the amino acid sequence of SEQ ID NO: Y or the amino acid sequence encoded by the cDNA in Clone ID NO: Z; (g) a nucleotide sequence encoding a biologically active fragment of a reproductive system associated polypeptide having the complete amino acid sequence of SEQ ID NO: Y or the complete amino acid sequence encoded by the cDNA in Clone ID NO: Z; (h) a nucleotide sequence encoding an antigenic fragment of a reproductive system associated polypeptide having the complete amino acid sequence of SEQ ID NO: Y or the complete amino acid sequence encoded by the cDNA in Clone ID NO: Z; and (i) a nucleotide sequence complementary to any of the nucleotide sequences in (a), (b), (c), (d), (e), (f), (g), or (h), above.

[0135] The present invention is also directed to nucleic acid molecules which comprise, or alternatively consist of, a nucleotide sequence which is at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or 100%, identical to, for example, any of the nucleotide sequences in (a), (b), (c), (d), (e), (f), (g), (h), or (i) above, the nucleotide coding sequence in SEQ ID NO: X or the complementary strand thereto, the nucleotide coding sequence of the cDNA contained in Clone ID NO: Z or the complementary strand thereto, a nucleotide sequence encoding the polypeptide of SEQ ID NO: Y, a nucleotide sequence encoding a polypeptide sequence encoded by the nucleotide sequence in SEQ ID NO: X, a polypeptide sequence encoded by the complement of the polynucleotide sequence in SEQ ID NO: X, a nucleotide sequence encoding the polypeptide encoded by the cDNA contained in Clone ID NO: Z, the nucleotide coding sequence in SEQ ID NO: X as defined in columns 8 and 9 of Table 2 or the complementary strand thereto, a nucleotide sequence encoding the polypeptide encoded by the nucleotide sequence in SEQ ID NO: X as defined in columns 8 and 9 of Table 2 or the complementary strand thereto, the nucleotide coding sequence in SEQ ID NO: B as defined in column 6 of Table 1B or the complementary strand thereto, a nucleotide sequence encoding the polypeptide encoded by the nucleotide sequence in SEQ ID NO: B as defined in column 6 of Table 1B or the complementary strand thereto, the nucleotide sequence in SEQ ID NO: X encoding the polypeptide sequence as defined in column 6 of Table 1A or the complementary strand thereto, nucleotide sequences encoding a polypeptide as defined in column 6 of Table 1A or the complementary strand thereto, and/or polynucleotide fragments of any of these nucleic acid molecules (e.g., those fragments described herein). Polynucleotides which hybridize to the complement of these nucleic acid molecules under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention, as are polypeptides encoded by these polynucleotides and nucleic acids.

[0136] In a preferred embodiment, the invention encompasses nucleic acid molecules which comprise, or alternatively, consist of a polynucleotide which hybridizes under stringent hybridization conditions, or alternatively, under lower stringency conditions, to a polynucleotide in (a), (b), (c), (d), (e), (f), (g), (h), or (i) above, as are polypeptides encoded by these polynucleotides. In another preferred embodiment, polynucleotides which hybridize to the complement of these nucleic acid molecules under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention, as are polypeptides encoded by these polynucleotides.

[0137] In another embodiment, the invention provides a purified protein comprising, or alternatively consisting of, a polypeptide having an amino acid sequence selected from the group consisting of: (a) the complete amino acid sequence of SEQ ID NO: Y or the complete amino acid sequence encoded by the cDNA in Clone ID NO: Z; (b) the amino acid sequence of a mature reproductive system associated polypeptide having the amino acid sequence of SEQ ID NO: Y or the amino acid sequence encoded by the cDNA in Clone ID NO: Z; (c) the amino acid sequence of a biologically active fragment of a reproductive system associated polypeptide having the complete amino acid sequence of SEQ ID NO: Y or the complete amino acid sequence encoded by the cDNA in Clone ID NO: Z; and (d) the amino acid sequence of an antigenic fragment of a reproductive system associated polypeptide having the complete amino acid sequence of SEQ ID NO: Y or the complete amino acid sequence encoded by the cDNA in Clone ID NO: Z.

[0138] The present invention is also directed to proteins which comprise, or alternatively consist of, an amino acid sequence which is at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or 100%, identical to, for example, any of the amino acid sequences in (a), (b), (c), or (d), above, the amino acid sequence shown in SEQ ID NO: Y, the amino acid sequence encoded by the cDNA contained in Clone ID NO: Z, the amino acid sequence of the polypeptide encoded by the nucleotide sequence in SEQ ID NO: X as defined in columns 8 and 9 of Table 2, the amino acid sequence of the polypeptide encoded by the nucleotide sequence in SEQ ID NO: B as defined in column 6 of Table 1B, the amino acid sequence as defined in column 6 of Table 1A, an amino acid sequence encoded by the nucleotide sequence in SEQ ID NO: X, and an amino acid sequence encoded by the complement of the polynucleotide sequence in SEQ ID NO: X. Fragments of these polypeptides are also provided (e.g., those fragments described herein). Further proteins encoded by polynucleotides which hybridize to the complement of the nucleic acid molecules encoding these amino acid sequences under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention, as are the polynucleotides encoding these proteins.

[0139] By a nucleic acid having a nucleotide sequence at least, for example, 95% “identical” to a reference nucleotide sequence of the present invention, it is intended that the nucleotide sequence of the nucleic acid is identical to the reference sequence except that the nucleotide sequence may include up to five point mutations per each 100 nucleotides of the reference nucleotide sequence encoding the polypeptide. In other words, to obtain a nucleic acid having a nucleotide sequence at least 95% identical to a reference nucleotide sequence, up to 5% of the nucleotides in the reference sequence may be deleted or substituted with another nucleotide, or a number of nucleotides up to 5% of the total nucleotides in the reference sequence may be inserted into the reference sequence. The query sequence may be an entire sequence referred to in Table 1A or 2 as the ORF (open reading frame), or any fragment specified, as described herein.

[0140] As a practical matter, whether any particular nucleic acid molecule or polypeptide is at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% identical to a nucleotide sequence of the present invention can be determined conventionally using known computer programs. A preferred method for determining the best overall match between a query sequence (a sequence of the present invention) and a subject sequence, also referred to as a global sequence alignment, can be determined using the FASTDB computer program based on the algorithm of Brutlag et al. (Comp. App. Biosci. 6:237-245 (1990)). In a sequence alignment the query and subject sequences are both DNA sequences. An RNA sequence can be compared by converting U's to T's. The result of said global sequence alignment is expressed as percent identity. Preferred parameters used in a FASTDB alignment of DNA sequences to calculate percent identity are: Matrix=Unitary, k-tuple=4, Mismatch Penalty=1, Joining Penalty=30, Randomization Group Length=0, Cutoff Score=1, Gap Penalty=5, Gap Size Penalty 0.05, Window Size=500 or the length of the subject nucleotide sequence, whichever is shorter.

[0141] If the subject sequence is shorter than the query sequence because of 5′ or 3′ deletions, not because of internal deletions, a manual correction must be made to the results. This is because the FASTDB program does not account for 5′ and 3′ truncations of the subject sequence when calculating percent identity. For subject sequences truncated at the 5′ or 3′ ends, relative to the query sequence, the percent identity is corrected by calculating the number of bases of the query sequence that are 5′ and 3′ of the subject sequence, which are not matched/aligned, as a percent of the total bases of the query sequence. Whether a nucleotide is matched/aligned is determined by results of the FASTDB sequence alignment. This percentage is then subtracted from the percent identity, calculated by the above FASTDB program using the specified parameters, to arrive at a final percent identity score. This corrected score is what is used for the purposes of the present invention. Only bases outside the 5′ and 3′ bases of the subject sequence, as displayed by the FASTDB alignment, which are not matched/aligned with the query sequence, are calculated for the purposes of manually adjusting the percent identity score.

[0142] For example, a 90 base subject sequence is aligned to a 100 base query sequence to determine percent identity. The deletions occur at the 5′ end of the subject sequence and therefore, the FASTDB alignment does not show a matched/alignment of the first 10 bases at 5′ end. The 10 unpaired bases represent 10% of the sequence (number of bases at the 5′ and 3′ ends not matched/total number of bases in the query sequence) so 10% is subtracted from the percent identity score calculated by the FASTDB program. If the remaining 90 bases were perfectly matched the final percent identity would be 90%. In another example, a 90 base subject sequence is compared with a 100 base query sequence. This time the deletions are internal deletions so that there are no bases on the 5′ or 3′ of the subject sequence which are not matched/aligned with the query. In this case the percent identity calculated by FASTDB is not manually corrected. Once again, only bases 5′ and 3′ of the subject sequence which are not matched/aligned with the query sequence are manually corrected for. No other manual corrections are to be made for the purposes of the present invention.

[0143] By a polypeptide having an amino acid sequence at least, for example, 95% “identical” to a query amino acid sequence of the present invention, it is intended that the amino acid sequence of the subject polypeptide is identical to the query sequence except that the subject polypeptide sequence may include up to five amino acid alterations per each 100 amino acids of the query amino acid sequence. In other words, to obtain a polypeptide having an amino acid sequence at least 95% identical to a query amino acid sequence, up to 5% of the amino acid residues in the subject sequence may be inserted, deleted, (indels) or substituted with another amino acid. These alterations of the reference sequence may occur at the amino or carboxy terminal positions of the reference amino acid sequence or anywhere between those terminal positions, interspersed either individually among residues in the reference sequence or in one or more contiguous groups within the reference sequence.

[0144] As a practical matter, whether any particular polypeptide is at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% identical to, for instance, the amino acid sequence of a polypeptide referred to in Table 1A (e.g., an amino acid sequence identified in columns 5 or 6) or Table 2 (e.g., the amino acid sequence of the polypeptide encoded by the polynucleotide sequence defined in columns 8 and 9 of Table 2) or a fragment thereof, the amino acid sequence of the polypeptide encoded by the polynucleotide sequence in SEQ ID NO: B as defined in column 6 of Table 1B or a fragment thereof, the amino acid sequence of the polypeptide encoded by the nucleotide sequence in SEQ ID NO: X or a fragment thereof, or an amino acid sequence of the polypeptide encoded by cDNA contained in Clone ID NO: Z, or a fragment thereof, can be determined conventionally using known computer programs. A preferred method for determining the best overall match between a query sequence (a sequence of the present invention) and a subject sequence, also referred to as a global sequence alignment, can be determined using the FASTDB computer program based on the algorithm of Brutlag et al. (Comp. App. Biosci.6:237-245 (1990)). In a sequence alignment the query and subject sequences are either both nucleotide sequences or both amino acid sequences. The result of said global sequence alignment is expressed as percent identity. Preferred parameters used in a FASTDB amino acid alignment are: Matrix=PAM 0, k-tuple=2, Mismatch Penalty=1, Joining Penalty=20, Randomization Group Length=0, Cutoff Score=1, Window Size=sequence length, Gap Penalty=5, Gap Size Penalty=0.05, Window Size=500 or the length of the subject amino acid sequence, whichever is shorter.

[0145] If the subject sequence is shorter than the query sequence due to N- or C-terminal deletions, not because of internal deletions, a manual correction must be made to the results. This is because the FASTDB program does not account for N- and C-terminal truncations of the subject sequence when calculating global percent identity. For subject sequences truncated at the N- and C-termini, relative to the query sequence, the percent identity is corrected by calculating the number of residues of the query sequence that are N- and C-terminal of the subject sequence, which are not matched/aligned with a corresponding subject residue, as a percent of the total bases of the query sequence. Whether a residue is matched/aligned is determined by results of the FASTDB sequence alignment. This percentage is then subtracted from the percent identity, calculated by the above FASTDB program using the specified parameters, to arrive at a final percent identity score. This final percent identity score is what is used for the purposes of the present invention. Only residues to the N- and C-termini of the subject sequence, which are not matched/aligned with the query sequence, are considered for the purposes of manually adjusting the percent identity score. That is, only query residue positions outside the farthest N- and C-terminal residues of the subject sequence.

[0146] For example, a 90 amino acid residue subject sequence is aligned with a 100 residue query sequence to determine percent identity. The deletion occurs at the N-terminus of the subject sequence and therefore, the FASTDB alignment does not show a matching/alignment of the first 10 residues at the N-terminus. The 10 unpaired residues represent 10% of the sequence (number of residues at the N- and C-termini not matched/total number of residues in the query sequence) so 10% is subtracted from the percent identity score calculated by the FASTDB program. If the remaining 90 residues were perfectly matched the final percent identity would be 90%. In another example, a 90 residue subject sequence is compared with a 100 residue query sequence. This time the deletions are internal deletions so there are no residues at the N- or C-termini of the subject sequence which are not matched/aligned with the query. In this case the percent identity calculated by FASTDB is not manually corrected. Once again, only residue positions outside the N- and C-terminal ends of the subject sequence, as displayed in the FASTDB alignment, which are not matched/aligned with the query sequence are manually corrected for. No other manual corrections are to be made for the purposes of the present invention.

[0147] The polynucleotide variants of the invention may contain alterations in the coding regions, non-coding regions, or both. Especially preferred are polynucleotide variants containing alterations which produce silent substitutions, additions, or deletions, but do not alter the properties or activities of the encoded polypeptide. Nucleotide variants produced by silent substitutions due to the degeneracy of the genetic code are preferred. Moreover, polypeptide variants in which less than 50, less than 40, less than 30, less than 20, less than 10, or 5-50, 5-25, 5-10, 1-5, or 1-2 amino acids are substituted, deleted, or added in any combination are also preferred. Polynucleotide variants can be produced for a variety of reasons, e.g., to optimize codon expression for a particular host (change codons in the human MRNA to those preferred by a bacterial host such as E. coli).

[0148] Naturally occurring variants are called “allelic variants,” and refer to one of several alternate forms of a gene occupying a given locus on a chromosome of an organism. (Genes II, Lewin, B., ed., John Wiley & Sons, New York (1985).) These allelic variants can vary at either the polynucleotide and/or polypeptide level and are included in the present invention. Alternatively, non-naturally occurring variants may be produced by mutagenesis techniques or by direct synthesis.

[0149] Using known methods of protein engineering and recombinant DNA technology, variants may be generated to improve or alter the characteristics of the polypeptides of the present invention. For instance, one or more amino acids can be deleted from the N-terminus or C-terminus of the polypeptides of the present invention without substantial loss of biological function. As an example, the authors of Ron et al., J. Biol. Chem. 268: 2984-2988 (1993), reported variant KGF proteins having heparin binding activity even after deleting 3, 8, or 27 amino-terminal amino acid residues. Similarly, Interferon gamma exhibited up to ten times higher activity after deleting 8-10 amino acid residues from the carboxy terminus of this protein. (Dobeli et al., J. Biotechnology 7:199-216 (1988).)

[0150] Moreover, ample evidence demonstrates that variants often retain a biological activity similar to that of the naturally occurring protein. For example, Gayle and coworkers (J. Biol. Chem. 268:22105-22111 (1993)) conducted extensive mutational analysis of human cytokine IL-1a. They used random mutagenesis to generate over 3,500 individual IL-1a mutants that averaged 2.5 amino acid changes per variant over the entire length of the molecule. Multiple mutations were examined at every possible amino acid position. The investigators found that “[m]ost of the molecule could be altered with little effect on either [binding or biological activity].” in fact, only 23 unique amino acid sequences, out of more than 3,500 nucleotide sequences examined, produced a protein that significantly differed in activity from wild-type.

[0151] Furthermore, even if deleting one or more amino acids from the N-terminus or C-terminus of a polypeptide results in modification or loss of one or more biological functions, other biological activities may still be retained. For example, the ability of a deletion variant to induce and/or to bind antibodies which recognize the secreted form will likely be retained when less than the majority of the residues of the secreted form are removed from the N-terminus or C-terminus. Whether a particular polypeptide lacking N- or C-terminal residues of a protein retains such immunogenic activities can readily be determined by routine methods described herein and otherwise known in the art.

[0152] Thus, the invention further includes polypeptide variants which show a functional activity (e.g., biological activity) of the polypeptides of the invention. Such variants include deletions, insertions, inversions, repeats, and substitutions selected according to general rules known in the art so as have little effect on activity.

[0153] The present application is directed to nucleic acid molecules at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or 100% identical to the nucleic acid sequences disclosed herein, (e.g., encoding a polypeptide having the amino acid sequence of an N and/or C terminal deletion), irrespective of whether they encode a polypeptide having functional activity. This is because even where a particular nucleic acid molecule does not encode a polypeptide having functional activity, one of skill in the art would still know how to use the nucleic acid molecule, for instance, as a hybridization probe or a polymerase chain reaction (PCR) primer. Uses of the nucleic acid molecules of the present invention that do not encode a polypeptide having functional activity include, inter alia, (1) isolating a gene or allelic or splice variants thereof in a cDNA library; (2) in situ hybridization (e.g., “FISH”) to metaphase chromosomal spreads to provide precise chromosomal location of the gene, as described in Verma et al., Human Chromosomes: A Manual of Basic Techniques, Pergamon Press, New York (1988); (3) Northern Blot analysis for detecting mRNA expression in specific tissues (e.g., normal reproductive system tissues or diseased reproductive system tissues); and (4) in situ hybridization (e.g., histochemistry) for detecting mRNA expression in specific tissues (e.g., normal reproductive system tissues or diseased reproductive system tissues).

[0154] Preferred, however, are nucleic acid molecules having sequences at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or 100% identical to the nucleic acid sequences disclosed herein, which do, in fact, encode a polypeptide having functional activity. By a polypeptide having “functional activity” is meant, a polypeptide capable of displaying one or more known functional activities associated with a full-length (complete) protein of the invention. Such functional activities include, but are not limited to, biological activity, antigenicity [ability to bind (or compete with a polypeptide of the invention for binding) to an anti-polypeptide of the invention antibody], immunogenicity (ability to generate antibody which binds to a specific polypeptide of the invention), ability to form multimers with polypeptides of the invention, and ability to bind to a receptor or ligand for a polypeptide of the invention.

[0155] The functional activity of the polypeptides, and fragments, variants and derivatives of the invention, can be assayed by various methods.

[0156] For example, in one embodiment where one is assaying for the ability to bind or compete with full-length polypeptide of the present invention for binding to an anti-polypeptide of the invention antibody, various immunoassays known in the art can be used, including but not limited to, competitive and non-competitive assay systems using techniques such as radioimmunoassays, ELISA (enzyme linked immunosorbent assay), “sandwich” immunoassays, immunoradiometric assays, gel diffusion precipitation reactions, immunodiffusion assays, in situ immunoassays (using colloidal gold, enzyme or radioisotope labels, for example), western blots, precipitation reactions, agglutination assays (e.g., gel agglutination assays, hemagglutination assays), complement fixation assays, immunofluorescence assays, protein A assays, and immunoelectrophoresis assays, etc. In one embodiment, antibody binding is detected by detecting a label on the primary antibody. In another embodiment, the primary antibody is detected by detecting binding of a secondary antibody or reagent to the primary antibody. In a further embodiment, the secondary antibody is labeled. Many means are known in the art for detecting binding in an immunoassay and are within the scope of the present invention.

[0157] In another embodiment, where a ligand is identified, or the ability of a polypeptide fragment, variant or derivative of the invention to multimerize is being evaluated, binding can be assayed, e.g., by means well-known in the art, such as, for example, reducing and non-reducing gel chromatography, protein affinity chromatography, and affinity blotting. See generally, Phizicky et al., Microbiol. Rev. 59:94-123 (1995). In another embodiment, the ability of physiological correlates of a polypeptide of the present invention to bind to a substrate(s) of the polypeptide of the invention can be routinely assayed using techniques known in the art.

[0158] In addition, assays described herein (see Examples) and otherwise known in the art may routinely be applied to measure the ability of polypeptides of the present invention and fragments, variants and derivatives thereof to elicit polypeptide related biological activity (either in vitro or in vivo). Other methods will be known to the skilled artisan and are within the scope of the invention.

[0159] Of course, due to the degeneracy of the genetic code, one of ordinary skill in the art will immediately recognize that a large number of the nucleic acid molecules having a sequence at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, or 100% identical to, for example, the nucleic acid sequence of the cDNA contained in Clone ID NO: Z, a nucleic acid sequence referred to in Table 1A (e.g., SEQ ID NO: X), a nucleic acid sequence disclosed in Table 2 (e.g., the nucleic acid sequence delineated in columns 8 and 9) or fragments thereof, will encode polypeptides “having functional activity.” In fact, since degenerate variants of any of these nucleotide sequences all encode the same polypeptide, in many instances, this will be clear to the skilled artisan even without performing the above described comparison assay. It will be further recognized in the art that, for such nucleic acid molecules that are not degenerate variants, a reasonable number will also encode a polypeptide having functional activity. This is because the skilled artisan is fully aware of amino acid substitutions that are either less likely or not likely to significantly effect protein function (e.g., replacing one aliphatic amino acid with a second aliphatic amino acid), as further described below.

[0160] For example, guidance concerning how to make phenotypically silent amino acid substitutions is provided in Bowie et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions,” Science 247:1306-1310 (1990), wherein the authors indicate that there are two main strategies for studying the tolerance of an amino acid sequence to change.

[0161] The first strategy exploits the tolerance of amino acid substitutions by natural selection during the process of evolution. By comparing amino acid sequences in different species, conserved amino acids can be identified. These conserved amino acids are likely important for protein function. In contrast, the amino acid positions where substitutions have been tolerated by natural selection indicates that these positions are not critical for protein function. Thus, positions tolerating amino acid substitution could be modified while still maintaining biological activity of the protein.

[0162] The second strategy uses genetic engineering to introduce amino acid changes at specific positions of a cloned gene to identify regions critical for protein function. For example, site directed mutagenesis or alanine-scanning mutagenesis (introduction of single alanine mutations at every residue in the molecule) can be used. See Cunningham et al., Science 244:1081-1085 (1989). The resulting mutant molecules can then be tested for biological activity.

[0163] As the authors state, these two strategies have revealed that proteins are surprisingly tolerant of amino acid substitutions. The authors further indicate which amino acid changes are likely to be permissive at certain amino acid positions in the protein. For example, most buried (within the tertiary structure of the protein) amino acid residues require nonpolar side chains, whereas few features of surface side chains are generally conserved. Moreover, tolerated conservative amino acid substitutions involve replacement of the aliphatic or hydrophobic amino acids Ala, Val, Leu and Ile; replacement of the hydroxyl residues Ser and Thr; replacement of the acidic residues Asp and Glu; replacement of the amide residues Asn and Gln, replacement of the basic residues Lys, Arg, and His; replacement of the aromatic residues Phe, Tyr, and Trp, and replacement of the small-sized amino acids Ala, Ser, Thr, Met, and Gly. Besides conservative amino acid substitutions, variants of the present invention include (i) substitutions with one or more of the non-conserved amino acid residues, where the substituted amino acid residues may or may not be one encoded by the genetic code, or (ii) substitutions with one or more of the amino acid residues having a substituent group, or (iii) fusion of the mature polypeptide with another compound, such as a compound to increase the stability and/or solubility of the polypeptide (for example, polyethylene glycol), or (iv) fusion of the polypeptide with additional amino acids, such as, for example, an IgG Fe fusion region peptide, serum albumin (preferably human serum albumin) or a fragment or variant thereof, or leader or secretory sequence, or a sequence facilitating purification. Such variant polypeptides are deemed to be within the scope of those skilled in the art from the teachings herein.

[0164] For example, polypeptide variants containing amino acid substitutions of charged amino acids with other charged or neutral amino acids may produce proteins with improved characteristics, such as less aggregation. Aggregation of pharmaceutical formulations both reduces activity and increases clearance due to the aggregate's immunogenic activity. See Pinckard et al., Clin. Exp. Immunol. 2:331-340 (1967); Robbins et al., Diabetes 36: 838-845 (1987); Cleland et al., Crit. Rev. Therapeutic Drug Carrier Systems 10:307-377 (1993).

[0165] A further embodiment of the invention relates to polypeptides which comprise the amino acid sequence of a polypeptide having an amino acid sequence which contains at least one amino acid substitution, but not more than 50 amino acid substitutions, even more preferably, not more than 40 amino acid substitutions, still more preferably, not more than 30 amino acid substitutions, and still even more preferably, not more than 20 amino acid substitutions from a polypeptide sequence disclosed herein. Of course it is highly preferable for a polypeptide to have an amino acid sequence which comprises the amino acid sequence of a polypeptide of SEQ ID NO: Y, an amino acid sequence encoded by SEQ ID NO: X, an amino acid sequence encoded by the portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2, an amino acid sequence encoded by the complement of SEQ ID NO: X, and/or the amino acid sequence encoded by cDNA contained in Clone ID NO: Z which contains, in order of ever-increasing preference, at least one, but not more than 10, 9, 8, 7, 6, 5, 4, 3, 2 or 1 amino acid substitutions.

[0166] In specific embodiments, the polypeptides of the invention comprise, or alternatively, consist of, fragments or variants of a reference amino acid sequence selected from: (a) the amino acid sequence of SEQ ID NO: Y or fragments thereof (e.g., the mature form and/or other fragments described herein); (b) the amino acid sequence encoded by SEQ ID NO: X or fragments thereof; (c) the amino acid sequence encoded by the complement of SEQ ID NO: X or fragments thereof; (d) the amino acid sequence encoded by the portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2 or fragments thereof; and (e) the amino acid sequence encoded by cDNA contained in Clone ID NO: Z or fragments thereof; wherein the fragments or variants have 1-5, 5-10, 5-25, 5-50, 10-50 or 50-150, amino acid residue additions, substitutions, and/or deletions when compared to the reference amino acid sequence. In preferred embodiments, the amino acid substitutions are conservative. Polynucleotides encoding these polypeptides are also encompassed by the invention.

[0167] Polynucleotide and Polypeptide Fragments

[0168] The present invention is also directed to polynucleotide fragments of the polynucleotides (nucleic acids) of the invention. In the present invention, a “polynucleotide fragment” refers to a polynucleotide having a nucleic acid sequence which, for example: is a portion of the cDNA contained in Clone ID NO: Z or the complementary strand thereto; is a portion of the polynucleotide sequence encoding the polypeptide encoded by the cDNA contained in Clone ID NO: Z or the complementary strand thereto; is a portion of a polynucleotide sequence encoding the amino acid sequence encoded by the region of SEQ ID NO: X as defined in columns 8 and 9 of Table 2 or the complementary strand thereto; is a portion of the polynucleotide sequence of SEQ ID NO: X as defined in columns 8 and 9 of Table 2 or the complementary strand thereto; is a portion of the polynucleotide sequence in SEQ ID NO: X or the complementary strand thereto; is a polynucleotide sequence encoding a portion of the polypeptide of SEQ ID NO: Y; is a polynucleotide sequence encoding a portion of a polypeptide encoded by SEQ ID NO: X; is a polynucleotide sequence encoding a portion of a polypeptide encoded by the complement of the polynucleotide sequence in SEQ ID NO: X; is a portion of a polynucleotide sequence encoding the amino acid sequence encoded by the region of SEQ ID NO: B as defined in column 6 of Table 1B or the complementary strand thereto; or is a portion of the polynucleotide sequence of SEQ ID NO: B as defined in column 6 of Table 1B or the complementary strand thereto.

[0169] The polynucleotide fragments of the invention are preferably at least about 15 nt, and more preferably at least about 20 nt, still more preferably at least about 30 nt, and even more preferably, at least about 40 nt, at least about 50 nt, at least about 75 nt, or at least about 150 nt in length. A fragment “at least 20 nt in length,” for example, is intended to include 20 or more contiguous bases from the cDNA sequence contained in Clone ID NO: Z, or the nucleotide sequence shown in SEQ ID NO: X or the complementary stand thereto. In this context “about” includes the particularly recited value or a value larger or smaller by several (5, 4, 3, 2, or 1) nucleotides, at either terminus or at both termini These nucleotide fragments have uses that include, but are not limited to, as diagnostic probes and primers as discussed herein. Of course, larger fragments (e.g., at least 160, 170, 180, 190, 200, 250, 500, 600, 1000, or 2000 nucleotides in length) are also encompassed by the invention.

[0170] Moreover, representative examples of polynucleotide fragments of the invention, comprise, or alternatively consist of, a sequence from about nucleotide number 1-50, 51-100, 101-150, 151-200, 201-250, 251-300, 301-350, 351-400, 401-450, 451-500, 501-550, 551-600, 651-700, 701-750, 751-800, 800-850, 851-900, 901-950, 951-1000, 1001-1050, 1051-1100, 1101-1150, 1151-1200, 1201-1250, 1251-1300, 1301-1350, 1351-1400, 1401-1450, 1451-1500, 1501-1550, 1551-1600, 1601-1650, 1651-1700, 1701-1750, 1751-1800, 1801-1850, 1851-1900, 1901-1950, 1951-2000, 2001-2050, 2051-2100, 2101-2150, 2151-2200, 2201-2250, 2251-2300, 2301-2350, 2351-2400, 2401-2450, 2451-2500, 2501-2550, 2551-2600, 2601-2650, 2651-2700, 2701-2750, 2751-2800, 2801-2850, 2851-2900, 2901-2950, 2951-3000, 3001-3050, 3051-3100, 3101-3150, 3151-3200, 3201-3250, 3251-3300, 3301-3350, 3351-3400, 3401-3450, 3451-3500, 3501-3550, 3551-3600, 3601-3650, 3651-3700, 3701-3750, 3751-3800, 3801-3850, 3851-3900, 3901-3950, 3951-4000, 4001-4050, 4051-4100, 4101-4150, 4151-4200, 4201-4250, 4251-4300, 4301-4350, 4351-4400, 4401-4450, 4451-4500, 4501-4550, 4551-4600, 4601-4650, 4651-4700, 4701-4750, 4751-4800, 4801-4850, 4851-4900, 4901-4950, 4951-5000, 5001-5050, 5051-5100, 5101-5150, 5151-5200, 5201-5250, 5251-5300, 5301-5350, 5351-5400, 5401-5450, 5451-5500, 5501-5550, 5551-5600, 5601-5650, 5651-5700, 5701-5750, 5751-5800, 5801-5850, 5851-5900, 5901-5950, 5951-6000, 6001-6050, 6051-6100, 6101-6150, 6151-6200, 6201-6250, 6251-6300, 6301-6350, 6351-6400, 6401-6450, 6451-6500, 6501-6550, 6551-6600, 6601-6650, 6651-6700, 6701-6750, 6751-6800, 6801-6850, 6851-6900, 6901-6950, 6951-7000, 7001-7050, 7051-7100, 7101-7150, 7151-7200, 7201-7250, 7251-7300 or 7301 to the end of SEQ ID NO: X, or the complementary strand thereto. In this context “about” includes the particularly recited range or a range larger or smaller by several (5, 4, 3, 2, or 1) nucleotides, at either terminus or at both termini. Preferably, these fragments encode a polypeptide which has a functional activity (e.g., biological activity). More preferably, these polynucleotides can be used as probes or primers as discussed herein. Polynucleotides which hybridize to one or more of these polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions are also encompassed by the invention, as are polypeptides encoded by these polynucleotides.

[0171] Further representative examples of polynucleotide fragments of the invention, comprise, or alternatively consist of, a sequence from about nucleotide number 1-50, 51-100, 101-150, 151-200, 201-250, 251-300, 301-350, 351-400, 401-450, 451-500, 501-550, 551-600, 651-700, 701-750, 751-800, 800-850, 851-900, 901-950, 951-1000, 1001-1050, 1051-1100, 1101-1150, 1151-1200, 1201-1250, 1251-1300, 1301-1350, 1351-1400, 1401-1450, 1451-1500, 1501-1550, 1551-1600, 1601-1650, 1651-1700, 1701-1750, 1751-1800, 1801-1850, 1851-1900, 1901-1950, 1951-2000, 2001-2050, 2051-2100, 2101-2150, 2151-2200, 2201-2250, 2251-2300, 2301-2350, 2351-2400, 2401-2450, 2451-2500, 2501-2550, 2551-2600, 2601-2650, 2651-2700, 2701-2750, 2751-2800, 2801-2850, 2851-2900, 2901-2950, 2951-3000, 3001-3050, 3051-3100, 3101-3150, 3151-3200, 3201-3250, 3251-3300, 3301-3350, 3351-3400, 3401-3450, 3451-3500, 3501-3550, 3551-3600, 3601-3650, 3651-3700, 3701-3750, 3751-3800, 3801-3850, 3851-3900, 3901-3950, 3951-4000, 4001-4050, 4051-4100, 4101-4150, 4151-4200, 4201-4250, 4251-4300, 4301-4350, 4351-4400, 4401-4450, 4451-4500, 4501-4550, 4551-4600, 4601-4650, 4651-4700, 4701-4750, 4751-4800, 4801-4850, 4851-4900, 4901-4950, 4951-5000, 5001-5050, 5051-5100, 5101-5150, 5151-5200, 5201-5250, 5251-5300, 5301-5350, 5351-5400, 5401-5450, 5451-5500, 5501-5550, 5551-5600, 5601-5650, 5651-5700, 5701-5750, 5751-5800, 5801-5850, 5851-5900, 5901-5950, 5951-6000, 6001-6050, 6051-6100, 6101-6150, 6151-6200, 6201-6250, 6251-6300, 6301-6350, 6351-6400, 6401-6450, 6451-6500, 6501-6550, 6551-6600, 6601-6650, 6651-6700, 6701-6750, 6751-6800, 6801-6850, 6851-6900, 6901-6950, 6951-7000, 7001-7050, 7051-7100, 7101-7150, 7151-7200, 7201-7250, 7251-7300 or 7301 to the end of the cDNA sequence contained in Clone ID NO: Z, or the complementary strand thereto. In this context “about” includes the particularly recited range or a range larger or smaller by several (5, 4, 3, 2, or 1) nucleotides, at either terminus or at both termini. Preferably, these fragments encode a polypeptide which has a functional activity (e.g., biological activity). More preferably, these polynucleotides can be used as probes or primers as discussed herein. Polynucleotides which hybridize to one or more of these polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions are also encompassed by the invention, as are polypeptides encoded by these polynucleotides.

[0172] Moreover, representative examples of polynucleotide fragments of the invention comprise, or alternatively consist of, a nucleic acid sequence comprising one, two, three, four, five, six, seven, eight, nine, ten, or more of the above described polynucleotide fragments of the invention in combination with a polynucleotide sequence delineated in Table 1B column 6. Additional, representative examples of polynucleotide fragments of the invention comprise, or alternatively consist of, a nucleic acid sequence comprising one, two, three, four, five, six, seven, eight, nine, ten, or more of the above described polynucleotide fragments of the invention in combination with a polynucleotide sequence that is the complementary strand of a sequence delineated in column 6 of Table 1B. In further embodiments, the above-described polynucleotide fragments of the invention comprise, or alternatively consist of, sequences delineated in Table 1B, column 6, and have a nucleic acid sequence which is different from that of the BAC fragment having the sequence disclosed in SEQ ID NO: B (see Table 1B, column 5). In additional embodiments, the above-described polynucleotide fragments of the invention comprise, or alternatively consist of, sequences delineated in Table 1B, column 6, and have a nucleic acid sequence which is different from that published for the BAC clone identified as BAC ID NO: A (see Table 1B, column 4). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated Table 1B, column 6, and have a nucleic acid sequence which is different from that contained in the BAC clone identified as BAC ID NO: A (see Table 1B, column 4). Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides and polypeptides are also encompassed by the invention.

[0173] In additional specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more fragments of the sequences delineated in column 6 of Table 1B, and the polynucleotide sequence of SEQ ID NO: X (e.g., as defined in Table 1B, column 2) or fragments or variants thereof Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.

[0174] In additional specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more fragments of the sequences delineated in column 6 of Table 1B which correspond to the same Clone ID NO: Z (see Table 1B, column 1), and the polynucleotide sequence of SEQ ID NO: X (e.g., as defined in Table 1A or 1B) or fragments or variants thereof. Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.

[0175] In further specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more fragments of the sequences delineated in the same row of column 6 of Table 1B, and the polynucleotide sequence of SEQ ID NO: X (e.g., as defined in Table 1A or 1B) or fragments or variants thereof. Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.

[0176] In additional specific embodiments, polynucleotides of the invention comprise, or alternatively consist of a polynucleotide sequence in which the 3′ 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B and the 5′ 10 polynucleotides of the sequence of SEQ ID NO: X are directly contiguous. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.

[0177] In additional specific embodiments, polynucleotides of the invention comprise, or alternatively consist of a polynucleotide sequence in which the 3′ 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B and the 5′ 10 polynucleotides of a fragment or variant of the sequence of SEQ ID NO: X (e.g., as described herein) are directly contiguous Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.

[0178] In further specific embodiments, polynucleotides of the invention comprise, or alternatively consist of a polynucleotide sequence in which the 3′ 10 polynucleotides of a fragment or variant of the sequence of SEQ ID NO: X and the 5′ 10 polynucleotides of the sequence of one of the sequences delineated in column 6 of Table 1B are directly contiguous. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.

[0179] In specific embodiments, polynucleotides of the invention comprise, or alternatively consist of a polynucleotide sequence in which the 3′ 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B and the 5′ 10 polynucleotides of another sequence in column 6 are directly contiguous. In preferred embodiments, the 3′ 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B is directly contiguous with the 5′ 10 polynucleotides of the next sequential exon delineated in Table 1B, column 6. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.

[0180] In the present invention, a “polypeptide fragment” refers to an amino acid sequence which is a portion of that contained in SEQ ID NO: Y, a portion of an amino acid sequence encoded by the portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2, a portion of an amino acid sequence encoded by the polynucleotide sequence of SEQ ID NO: X, a portion of an amino acid sequence encoded by the complement of the polynucleotide sequence in SEQ ID NO: X, and/or a portion of an amino acid sequence encoded by the cDNA contained in Clone ID NO: Z. Protein (polypeptide) fragments may be “free-standing,” or comprised within a larger polypeptide of which the fragment forms a part or region, most preferably as a single continuous region. Representative examples of polypeptide fragments of the invention, include, for example, fragments comprising, or alternatively consisting of, from about amino acid number 1-20, 21-40, 41-60, 61-80, 81-100, 102-120, 121-140, 141-160, 161-180, 181-200, 201-220, 221-240, 241-260, 261-280, 281-300, 301-320, 321-340, 341-360, 361-380, 381-400, 401-420, 421-440, 441-460, 461-480, 481-500, 501-520, 521-540, 541-560, 561-580, 581-600, 601-620, 621-640, 641-660, 661-680, 681-700, 701-720, 721-740, 741-760, 761-780, 781-800, 801-820, 821-840, 841-860, 861-880, 881-900, 901-920, 921-940, 941-960, 961-980, 981-1000, 1001-1020, 1021-1040, 1041-1060, 1061-1080, 1081-1100, 1101-1120, 1121-1140, 1141-1160, 1161-1180, 1181-1200, 1201-1220, 1221-1240, 1241-1260, 1261-1280, 1281-1300, 1301-1320, 1321-1340, 1341-1360, 1361-1380, 1381-1400, 1401-1420, 1421-1440, or 1441 to the end of the coding region. In a preferred embodiment, polypeptide fragments of the invention include, for example, fragments comprising, or alternatively consisting of, from about amino acid number 1-20, 21-40, 41-60, 61-80, 81-100, 102-120, 121-140, 141-160, 161-180, 181-200, 201-220, 221-240, 241-260, 261-280, 281-300, 301-320, 321-340, 341-360, 361-380, 381-400, 401-420, 421-440, 441-460, 461-480, 481-500, 501-520, 521-540, 541-560, 561-580, 581-600, 601-620, 621-640, 641-660, 661-680, 681-700, 701-720, 721-740, 741-760, 761-780, 781-800, 801-820, 821-840, 841-860, 861-880, 881-900, 901-920, 921-940, 941-960, 961-980, 981-1000, 1001-1020, 1021-1040, 1041-1060, 1061-1080, 1081-1100, 1101-1120, 1121-1140, 1141-1160, 1161-1180, 1181-1200, 1201-1220, 1221-1240, 1241-1260, 1261-1280, 1281-1300, 1301-1320, 1321-1340, 1341-1360, 1361-1380, 1381-1400, 1401-1420, 1421-1440, or 1441 to the end of the coding region of SEQ ID NO: Y. Moreover, polypeptide fragments of the invention may be at least about 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 100, 110, 120, 130, 140, or 150 amino acids in length. In this context “about” includes the particularly recited ranges or values, or ranges or values larger or smaller by several (5, 4, 3, 2, or 1) amino acids, at either extreme or at both extremes. Polynucleotides encoding these polypeptide fragments are also encompassed by the invention.

[0181] Even if deletion of one or more amino acids from the N-terminus of a protein results in modification of loss of one or more biological functions of the protein, other functional activities (e.g., biological activities, ability to multimerize, ability to bind a ligand) may still be retained. For example, the ability of shortened muteins to induce and/or bind to antibodies which recognize the complete or mature forms of the polypeptides generally will be retained when less than the majority of the residues of the complete or mature polypeptide are removed from the N-terminus. Whether a particular polypeptide lacking N-terminal residues of a complete polypeptide retains such immunologic activities can readily be determined by routine methods described herein and otherwise known in the art. It is not unlikely that a mutein with a large number of deleted N-terminal amino acid residues may retain some biological or immunogenic activities. In fact, peptides composed of as few as six amino acid residues may often evoke an immune response.

[0182] Accordingly, polypeptide fragments include the secreted protein as well as the mature form. Further preferred polypeptide fragments include the secreted protein or the mature form having a continuous series of deleted residues from the amino or the carboxy terminus, or both. For example, any number of amino acids, ranging from 1-60, can be deleted from the amino terminus of either the secreted polypeptide or the mature form. Similarly, any number of amino acids, ranging from 1-30, can be deleted from the carboxy terminus of the secreted protein or mature form. Furthermore, any combination of the above amino and carboxy terminus deletions is preferred. Similarly, polynucleotides encoding these polypeptide fragments are also preferred.

[0183] The present invention further provides polypeptides having one or more residues deleted from the amino terminus of the amino acid sequence of a polypeptide disclosed herein (e.g., a polypeptide of SEQ ID NO: Y, a polypeptide encoded by the polynucleotide sequence contained in SEQ ID NO: X or the complement thereof, a polypeptide encoded by the portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2, a polypeptide encoded by the portion of SEQ ID NO: B as defined in column 6 of Table 1B, and/or a polypeptide encoded by the cDNA contained in Clone ID NO: Z). In particular, N-terminal deletions may be described by the general formula m−q, where q is a whole integer representing the total number of amino acid residues in a polypeptide of the invention (e.g., the polypeptide disclosed in SEQ ID NO: Y, or the polypeptide encoded by the portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2), and m is defined as any integer ranging from 2 to q−6. Polynucleotides encoding these polypeptides are also encompassed by the invention.

[0184] The present invention further provides polypeptides having one or more residues from the carboxy terminus of the amino acid sequence of a polypeptide disclosed herein (e.g., a polypeptide of SEQ ID NO: Y, a polypeptide encoded by the polynucleotide sequence contained in SEQ ID NO: X, a polypeptide encoded by the portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2, and/or a polypeptide encoded by the cDNA contained in Clone ID NO: Z). In particular, C-terminal deletions may be described by the general formula 1−n, where n is any whole integer ranging from 6 to q−1, and where n corresponds to the position of amino acid residue in a polypeptide of the invention. Polynucleotides encoding these polypeptides are also encompassed by the invention.

[0185] In addition, any of the above described N- or C-terminal deletions can be combined to produce a N- and C-terminal deleted polypeptide. The invention also provides polypeptides having one or more amino acids deleted from both the amino and the carboxyl termini, which may be described generally as having residues m−n of a polypeptide encoded by SEQ ID NO: X (e.g., including, but not limited to, the preferred polypeptide disclosed as SEQ ID NO: Y and the polypeptide encoded by the portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2), the cDNA contained in Clone ID NO: Z, and/or the complement thereof, where n and m are integers as described above. Polynucleotides encoding these polypeptides are also encompassed by the invention.

[0186] Also as mentioned above, even if deletion of one or more amino acids from the C-terminus of a protein results in modification of loss of one or more biological functions of the protein, other functional activities (e.g., biological activities, ability to multimerize, ability to bind a ligand) may still be retained. For example the ability of the shortened mutein to induce and/or bind to antibodies which recognize the complete or mature forms of the polypeptide generally will be retained when less than the majority of the residues of the complete or mature polypeptide are removed from the C-terminus. Whether a particular polypeptide lacking C-terminal residues of a complete polypeptide retains such immunologic activities can readily be determined by routine methods described herein and otherwise known in the art. It is not unlikely that a mutein with a large number of deleted C-terminal amino acid residues may retain some biological or immunogenic activities. In fact, peptides composed of as few as six amino acid residues may often evoke an immune response.

[0187] The present application is also directed to proteins containing polypeptides at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% identical to a polypeptide sequence set forth herein. In preferred embodiments, the application is directed to proteins containing polypeptides at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% identical to polypeptides having the amino acid sequence of the specific N- and C-terminal deletions. Polynucleotides encoding these polypeptides are also encompassed by the invention.

[0188] Any polypeptide sequence encoded by, for example, the polynucleotide sequences set forth as SEQ ID NO: X or the complement thereof, (presented, for example, in Tables 1A and 2), the cDNA contained in Clone ID NO: Z, or the polynucleotide sequence as defined in column 6 of Table 1B, may be analyzed to determine certain preferred regions of the polypeptide. For example, the amino acid sequence of a polypeptide encoded by a polynucleotide sequence of SEQ ID NO: X (e.g., the polypeptide of SEQ ID NO: Y and the polypeptide encoded by the portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2) or the cDNA contained in Clone ID NO: Z may be analyzed using the default parameters of the DNASTAR computer algorithm (DNASTAR, Inc., 1228 S. Park St., Madison, Wis. 53715 USA; http://www.dnastar.com/).

[0189] Polypeptide regions that may be routinely obtained using the DNASTAR computer algorithm include, but are not limited to, Garnier-Robson alpha-regions, beta-regions, turn-regions, and coil-regions; Chou-Fasman alpha-regions, beta-regions, and turn-regions; Kyte-Doolittle hydrophilic regions and hydrophobic regions; Eisenberg alpha- and beta-amphipathic regions; Karplus-Schulz flexible regions; Emini surface-forming regions; and Jameson-Wolf regions of high antigenic index. Among highly preferred polynucleotides of the invention in this regard are those that encode polypeptides comprising regions that combine several structural features, such as several (e.g., 1, 2, 3 or 4) of the features set out above.

[0190] Additionally, Kyte-Doolittle hydrophilic regions and hydrophobic regions, Emini surface-forming regions, and Jameson-Wolf regions of high antigenic index (i.e., containing four or more contiguous amino acids having an antigenic index of greater than or equal to 1.5, as identified using the default parameters of the Jameson-Wolf program) can routinely be used to determine polypeptide regions that exhibit a high degree of potential for antigenicity. Regions of high antigenicity are determined from data by DNASTAR analysis by choosing values which represent regions of the polypeptide which are likely to be exposed on the surface of the polypeptide in an environment in which antigen recognition may occur in the process of initiation of an immune response.

[0191] Preferred polypeptide fragments of the invention are fragments comprising, or alternatively, consisting of, an amino acid sequence that displays a functional activity (e.g. biological activity) of the polypeptide sequence of which the amino acid sequence is a fragment. By a polypeptide displaying a “functional activity” is meant a polypeptide capable of one or more known functional activities associated with a full-length protein, such as, for example, biological activity, antigenicity, immunogenicity, and/or multimerization, as described herein.

[0192] Other preferred polypeptide fragments are biologically active fragments. Biologically active fragments are those exhibiting activity similar, but not necessarily identical, to an activity of the polypeptide of the present invention. The biological activity of the fragments may include an improved desired activity, or a decreased undesirable activity.

[0193] In preferred embodiments, polypeptides of the invention comprise, or alternatively consist of, one, two, three, four, five or more of the antigenic fragments of the polypeptide of SEQ ID NO: Y, or portions thereof. Polynucleotides encoding these polypeptides are also encompassed by the invention.

[0194] The present invention encompasses polypeptides comprising, or alternatively consisting of, an epitope of: the polypeptide sequence shown in SEQ ID NO: Y; a polypeptide sequence encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide sequence encoded by the portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2; the polypeptide sequence encoded by the portion of SEQ ID NO: B as defined in column 6 of Table 1B or the complement thereto; the polypeptide sequence encoded by the cDNA contained in Clone ID NO: Z; or the polypeptide sequence encoded by a polynucleotide that hybridizes to the sequence of SEQ ID NO: X, the complement of the sequence of SEQ ID NO: X, the complement of a portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2, or the cDNA sequence contained in Clone ID NO: Z under stringent hybridization conditions or alternatively, under lower stringency hybridization as defined supra. The present invention further encompasses polynucleotide sequences encoding an epitope of a polypeptide sequence of the invention (such as, for example, the sequence disclosed in SEQ ID NO: X, or a fragment thereof), polynucleotide sequences of the complementary strand of a polynucleotide sequence encoding an epitope of the invention, and polynucleotide sequences which hybridize to the complementary strand under stringent hybridization conditions or alternatively, under lower stringency hybridization conditions defined supra.

[0195] The term “epitopes,” as used herein, refers to portions of a polypeptide having antigenic or immunogenic activity in an animal, preferably a mammal, and most preferably in a human. In a preferred embodiment, the present invention encompasses a polypeptide comprising an epitope, as well as the polynucleotide encoding this polypeptide. An “immunogenic epitope,” as used herein, is defined as a portion of a protein that elicits an antibody response in an animal, as determined by any method known in the art, for example, by the methods for generating antibodies described infra. (See, for example, Geysen et al., Proc. Natl. Acad. Sci. USA 81:3998-4002 (1983)). The term “antigenic epitope,” as used herein, is defined as a portion of a protein to which an antibody can immunospecifically bind its antigen as determined by any method well known in the art, for example, by the immunoassays described herein. Immunospecific binding excludes non-specific binding but does not necessarily exclude cross-reactivity with other antigens. Antigenic epitopes need not necessarily be immunogenic.

[0196] Fragments which function as epitopes may be produced by any conventional means. (See, e.g., Houghten, R. A., Proc. Natl. Acad. Sci. USA 82:5131-5135 (1985) further described in U.S. Patent No. 4,631,211.) 101781 In the present invention, antigenic epitopes preferably contain a sequence of at least 4, at least 5, at least 6, at least 7, more preferably at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 20, at least 25, at least 30, at least 40, at least 50, and, most preferably, between about 15 to about 30 amino acids. Preferred polypeptides comprising immunogenic or antigenic epitopes are at least 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, or 100 amino acid residues in length. Additional non-exclusive preferred antigenic epitopes include the antigenic epitopes disclosed herein, as well as portions thereof. Antigenic epitopes are useful, for example, to raise antibodies, including monoclonal antibodies, that specifically bind the epitope. Preferred antigenic epitopes include the antigenic epitopes disclosed herein, as well as any combination of two, three, four, five or more of these antigenic epitopes. Antigenic epitopes can be used as the target molecules in immunoassays. (See, for instance, Wilson et al., Cell 37:767-778 (1984); Sutcliffe et al., Science 219:660-666 (1983)).

[0197] Non-limiting examples of epitopes of polypeptides that can be used to generate antibodies of the invention include a polypeptide comprising, or alternatively consisting of, at least one, two, three, four, five, six or more of the portion(s) of SEQ ID NO: Y specified in column 6 of Table 1A. These polypeptide fragments have been determined to bear antigenic epitopes of the proteins of the invention by the analysis of the Jameson-Wolf antigenic index which is included in the DNAStar suite of computer programs. By “comprise” it is intended that a polypeptide contains at least one, two, three, four, five, six or more of the portion(s) of SEQ ID NO: Y shown in column 6 of Table 1A, but it may contain additional flanking residues on either the amino or carboxyl termini of the recited portion. Such additional flanking sequences are preferably sequences naturally found adjacent to the portion; i.e., contiguous sequence shown in SEQ ID NO: Y. The flanking sequence may, however, be sequences from a heterologous polypeptide, such as from another protein described herein or from a heterologous polypeptide not described herein. In particular embodiments, epitope portions of a polypeptide of the invention comprise one, two, three, or more of the portions of SEQ ID NO: Y shown in column 6 of Table 1A. Polynucleotides encoding these polypeptides are also encompassed by the invention.

[0198] Similarly, immunogenic epitopes can be used, for example, to induce antibodies according to methods well known in the art. See, for instance, Sutcliffe et al., supra; Wilson et al., supra; Chow et al., Proc. Natl. Acad. Sci. USA 82:910-914; and Bittle et al., J. Gen. Virol. 66:2347-2354 (1985). Preferred immunogenic epitopes include the immunogenic epitopes disclosed herein, as well as any combination of two, three, four, five or more of these immunogenic epitopes. The polypeptides comprising one or more immunogenic epitopes may be presented for eliciting an antibody response together with a carrier protein, such as an albumin, to an animal system (such as rabbit or mouse), or, if the polypeptide is of sufficient length (at least about 25 amino acids), the polypeptide may be presented without a carrier. However, immunogenic epitopes comprising as few as 8 to 10 amino acids have been shown to be sufficient to raise antibodies capable of binding to, at the very least, linear epitopes in a denatured polypeptide (e.g., in Western blotting).

[0199] Epitope-bearing polypeptides of the present invention may be used to induce antibodies according to methods well known in the art including, but not limited to, in vivo immunization, in vitro immunization, and phage display methods. See, e.g., Sutcliffe et al., supra; Wilson et al., supra, and Bittle et al., J. Gen. Virol., 66:2347-2354 (1985). If in vivo immunization is used, animals may be immunized with free peptide; however, anti-peptide antibody titer may be boosted by coupling the peptide to a macromolecular carrier, such as keyhole limpet hemacyanin (KLH) or tetanus toxoid. For instance, peptides containing cysteine residues may be coupled to a carrier using a linker such as maleimidobenzoyl- N-hydroxysuccinimide ester (MBS), while other peptides may be coupled to carriers using a more general linking agent such as glutaraldehyde. Animals such as rabbits, rats and mice are immunized with either free or carrier- coupled peptides, for instance, by intraperitoneal and/or intradermal injection of emulsions containing about 100 μg of peptide or carrier protein and Freund's adjuvant or any other adjuvant known for stimulating an immune response. Several booster injections may be needed, for instance, at intervals of about two weeks, to provide a useful titer of anti-peptide antibody which can be detected, for example, by ELISA assay using free peptide adsorbed to a solid surface. The titer of anti-peptide antibodies in serum from an immunized animal may be increased by selection of anti-peptide antibodies, for instance, by adsorption to the peptide on a solid support and elution of the selected antibodies according to methods well known in the art.

[0200] As one of skill in the art will appreciate, and as discussed above, the polypeptides of the present invention (e.g., those comprising an immunogenic or antigenic epitope) can be fused to heterologous polypeptide sequences. For example, polypeptides of the present invention (including fragments or variants thereof), may be fused with the constant domain of immunoglobulins (IgA, IgE, IgG, IgM), or portions thereof (CH1, CH2, CH3, or any combination thereof and portions thereof, resulting in chimeric polypeptides. By way of another non-limiting example, polypeptides and/or antibodies of the present invention (including fragments or variants thereof) may be fused with albumin (including but not limited to recombinant human serum albumin or fragments or variants thereof (see, e.g., U.S. Pat. No. 5,876,969, issued Mar. 2, 1999, EP Patent 0 413 622, and U.S. Pat. No. 5,766,883, issued Jun. 16, 1998, herein incorporated by reference in their entirety)). In a preferred embodiment, polypeptides and/or antibodies of the present invention (including fragments or variants thereof) are fused with the mature form of human serum albumin (i.e., amino acids 1-585 of human serum albumin as shown in FIGS. 1 and 2 of EP Patent 0 322 094) which is herein incorporated by reference in its entirety. In another preferred embodiment, polypeptides and/or antibodies of the present invention (including fragments or variants thereof) are fused with polypeptide fragments comprising, or alternatively consisting of, amino acid residues 1-z of human serum albumin, where z is an integer from 369 to 419, as described in U.S. Pat. No. 5,766,883 herein incorporated by reference in its entirety. Polypeptides and/or antibodies of the present invention (including fragments or variants thereof) may be fused to either the N- or C-terminal end of the heterologous protein (e.g., immunoglobulin Fc polypeptide or human serum albumin polypeptide). Polynucleotides encoding fusion proteins of the invention are also encompassed by the invention.

[0201] Such fusion proteins as those described above may facilitate purification and may increase half-life in vivo. This has been shown for chimeric proteins consisting of the first two domains of the human CD4-polypeptide and various domains of the constant regions of the heavy or light chains of mammalian immunoglobulins. See, e.g., EP 394,827; Traunecker et al., Nature, 331:84-86 (1988). Enhanced delivery of an antigen across the epithelial barrier to the immune system has been demonstrated for antigens (e.g., insulin) conjugated to an FcRn binding partner such as IgG or Fc fragments (see, e.g., PCT Publications WO 96/22024 and WO 99/04813). IgG Fusion proteins that have a disulfide-linked dimeric structure due to the IgG portion desulfide bonds have also been found to be more efficient in binding and neutralizing other molecules than monomeric polypeptides or fragments thereof alone. See, e.g., Fountoulakis et al., J. Biochem., 270:3958-3964 (1995). Nucleic acids encoding the above epitopes can also be recombined with a gene of interest as an epitope tag (e.g., the hemagglutinin (íHAî) tag or flag tag) to aid in detection and purification of the expressed polypeptide. For example, a system described by Janknecht et al. allows for the ready purification of non-denatured fusion proteins expressed in human cell lines (Janknecht et al., 1991, Proc. Natl. Acad. Sci. USA 88:8972-897). In this system, the gene of interest is subcloned into a vaccinia recombination plasmid such that the open reading frame of the gene is translationally fused to an amino-terminal tag consisting of six histidine residues. The tag serves as a matrix binding domain for the fusion protein. Extracts from cells infected with the recombinant vaccinia virus are loaded onto Ni2+ nitriloacetic acid-agarose column and histidine-tagged proteins can be selectively eluted with imidazole-containing buffers.

[0202] Fusion Proteins

[0203] Any polypeptide of the present invention can be used to generate fusion proteins. For example, the polypeptide of the present invention, when fused to a second protein, can be used as an antigenic tag. Antibodies raised against the polypeptide of the present invention can be used to indirectly detect the second protein by binding to the polypeptide. Moreover, because secreted proteins target cellular locations based on trafficking signals, polypeptides of the present invention which are shown to be secreted can be used as targeting molecules once fused to other proteins.

[0204] Examples of domains that can be fused to polypeptides of the present invention include not only heterologous signal sequences, but also other heterologous functional regions. The fusion does not necessarily need to be direct, but may occur through linker sequences.

[0205] In certain preferred embodiments, proteins of the invention are fusion proteins comprising an amino acid sequence that is an N and/or C-terminal deletion of a polypeptide of the invention. In preferred embodiments, the invention is directed to a fusion protein comprising an amino acid sequence that is at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% identical to a polypeptide sequence of the invention. Polynucleotides encoding these proteins are also encompassed by the invention.

[0206] Moreover, fusion proteins may also be engineered to improve characteristics of the polypeptide of the present invention. For instance, a region of additional amino acids, particularly charged amino acids, may be added to the N-terminus of the polypeptide to improve stability and persistence during purification from the host cell or subsequent handling and storage. Also, peptide moieties may be added to the polypeptide to facilitate purification. Such regions may be removed prior to final preparation of the polypeptide. The addition of peptide moieties to facilitate handling of polypeptides are familiar and routine techniques in the art.

[0207] As one of skill in the art will appreciate that, as discussed above, polypeptides of the present invention, and epitope-bearing fragments thereof, can be combined with heterologous polypeptide sequences. For example, the polypeptides of the present invention may be fused with heterologous polypeptide sequences, for example, the polypeptides of the present invention may be fused with the constant domain of immunoglobulins (IgA, IgE, IgG, IgM) or portions thereof (CH1, CH2, CH3, and any combination thereof, including both entire domains and portions thereof), or albumin (including, but not limited to, native or recombinant human albumin or fragments or variants thereof (see, e.g., U.S. Pat. No. 5,876,969, issued Mar. 2, 1999, EP Patent 0 413 622, and U.S. Pat. No. 5,766,883, issued Jun. 16, 1998, herein incorporated by reference in their entirety)), resulting in chimeric polypeptides. For example, EP-A-0 464 533 (Canadian counterpart 2045869) discloses fusion proteins comprising various portions of constant region of immunoglobulin molecules together with another human protein or part thereof. In many cases, the Fe part in a fusion protein is beneficial in therapy and diagnosis, and thus can result in, for example, improved pharmacokinetic properties (EP-A 0232 262). Alternatively, deleting the Fe part after the fusion protein has been expressed, detected, and purified, would be desired. For example, the Fe portion may hinder therapy and diagnosis if the fusion protein is used as an antigen for immunizations. In drug discovery, for example, human proteins, such as hIL-5, have been fused with Fe portions for the purpose of high-throughput screening assays to identify antagonists of hIL-5. See, D. Bennett et al., J. Molecular Recognition 8:52-58 (1995); K. Johanson et al., J. Biol. Chem. 270:9459-9471 (1995).

[0208] Moreover, the polypeptides of the present invention can be fused to marker sequences, such as a polypeptide which facilitates purification of the fused polypeptide. In preferred embodiments, the marker amino acid sequence is a hexa-histidine peptide, such as the tag provided in a pQE vector (QIAGEN, Inc., 9259 Eton Avenue, Chatsworth, Calif., 91311), among others, many of which are commercially available. As described in Gentz et al., Proc. Natl. Acad. Sci. USA 86:821-824 (1989), for instance, hexa-histidine provides for convenient purification of the fusion protein. Another peptide tag useful for purification, the “HA” tag, corresponds to an epitope derived from the influenza hemagglutinin protein (Wilson et al., Cell 37:767 (1984).)

[0209] Additional fusion proteins of the invention may be generated through the techniques of gene-shuffling, motif-shuffling, exon-shuffling, and/or codon-shuffling (collectively referred to as “DNA shuffling”), briefly described below, and further described herein. DNA shuffling may be employed to modulate the activities of polypeptides of the invention, such methods can be used to generate polypeptides with altered activity, as well as agonists and antagonists of the polypeptides. See, generally, U.S. Pat. Nos. 5,605,793; 5,811,238; 5,830,721; 5,834,252; and 5,837,458, and Patten et al., Curr. Opinion Biotechnol. 8:724-33 (1997); Harayama, Trends Biotechnol. 16(2):76-82 (1998); Hansson et al., J. Mol. Biol. 287:265-76 (1999); and Lorenzo and Blasco, Biotechniques 24(2):308-13 (1998); each of these patents and publications are hereby incorporated by reference in its entirety). In a preferred embodiment, one or more components, motifs, sections, parts, domains, fragments, etc., of a polynucleotide encoding a polypeptide of the invention may be recombined with one or more components, motifs, sections, parts, domains, fragments, etc., of one or more heterologous molecules encoding a heterologous polypeptide.

[0210] Thus, any of these above fusions can be engineered using the polynucleotides or the polypeptides of the present invention.

[0211] Recombinant and Synthetic Production of Polypeptides of the Invention

[0212] The present invention also relates to vectors containing the polynucleotide of the present invention, host cells, and the production of polypeptides by synthetic and recombinant techniques. The vector may be, for example, a phage, plasmid, viral, or retroviral vector. Retroviral vectors may be replication competent or replication defective. In the latter case, viral propagation generally will occur only in complementing host cells.

[0213] The polynucleotides of the invention may be joined to a vector containing a selectable marker for propagation in a host. Generally, a plasmid vector is introduced in a precipitate, such as a calcium phosphate precipitate, or in a complex with a charged lipid. If the vector is a virus, it may be packaged in vitro using an appropriate packaging cell line and then transduced into host cells.

[0214] The polynucleotide insert should be operatively linked to an appropriate promoter, such as the phage lambda PL promoter, the E. coli lac, trp, phoA and tac promoters, the SV40 early and late promoters and promoters of retroviral LTRs, to name a few. Other suitable promoters will be known to the skilled artisan. The expression constructs will further contain sites for transcription initiation, termination, and, in the transcribed region, a ribosome binding site for translation. The coding portion of the transcripts expressed by the constructs will preferably include a translation initiating codon at the beginning and a termination codon (UAA, UGA or UAG) appropriately positioned at the end of the polypeptide to be translated.

[0215] As indicated, the expression vectors will preferably include at least one selectable marker. Such markers include dihydrofolate reductase, G418 or neomycin resistance, glutamine synthase, for eukaryotic cell culture and tetracycline, kanamycin or ampicillin resistance genes for culturing in E. coli and other bacteria. Representative examples of appropriate hosts include, but are not limited to, bacterial cells, such as E. coli, Streptomyces and Salmonella typhimurium cells; fungal cells, such as yeast cells (e.g., Saccharomyces cerevisiae or Pichia pastoris (ATCC Accession No. 201178)); insect cells such as Drosophila S2 and Spodoptera Sf9 cells; animal cells such as CHO, COS, 293, NSO and Bowes melanoma cells; and plant cells. Appropriate culture mediums and conditions for the above-described host cells are known in the art.

[0216] Among vectors preferred for use in bacteria include pQE70, pQE60 and pQE-9, available from QIAGEN, Inc.; pBluescript vectors, Phagescript vectors, pNH8A, pNHl6a, pNH18A, pNH46A, available from Stratagene Cloning Systems, Inc.; and ptrc99a, pKK223-3, pKK233-3, pDR540, pRIT5 available from Pharmacia Biotech, Inc. Among preferred eukaryotic vectors are pWLNEO, pSV2CAT, pOG44, pXT1 and pSG available from Stratagene; and pSVK3, pBPV, pMSG and pSVL available from Pharmacia. Preferred expression vectors for use in yeast systems include, but are not limited to pYES2, pYD1, pTEF1/Zeo, pYES2/GS, pPICZ, pGAPZ, pGAPZalph, pPIC9, pPIC3.5, pHIL-D2, pHIL-SI, pPIC3.5K, pPIC9K, and PAO815 (all available from Invitrogen, Carlsbad, Calif.). Other suitable vectors will be readily apparent to the skilled artisan.

[0217] Vectors which use glutamine synthase (GS) or DHFR as the selectable markers can be amplified in the presence of the drugs methionine sulphoximine or methotrexate, respectively. An advantage of glutamine synthase based vectors is the availabilty of cell lines (e.g., the murine myeloma cell line, NSO) which are glutamine synthase negative. Glutamine synthase expression systems can also function in glutamine synthase expressing cells (e.g., Chinese Hamster Ovary (CHO) cells) by providing additional inhibitor to prevent the functioning of the endogenous gene. A glutamine synthase expression system and components thereof are detailed in PCT publications: WO87/04462; WO86/05807; WO89/01036; WO89/10404; and WO91/06657 which are hereby incorporated in their entireties by reference herein. Additionally, glutamine synthase expression vectors can be obtained from Lonza Biologics, Inc. (Portsmouth, N.H.). Expression and production of monoclonal antibodies using a GS expression system in murine myeloma cells is described in Bebbington et al., Bio/technology 10:169(1992) and in Biblia and Robinson Biotechnol. Prog. 11:1 (1995) which are herein incorporated by reference.

[0218] The present invention also relates to host cells containing the above-described vector constructs described herein, and additionally encompasses host cells containing nucleotide sequences of the invention that are operably associated with one or more heterologous control regions (e.g., promoter and/or enhancer) using techniques known of in the art. The host cell can be a higher eukaryotic cell, such as a mammalian cell (e.g., a human derived cell), or a lower eukaryotic cell, such as a yeast cell, or the host cell can be a prokaryotic cell, such as a bacterial cell. A host strain may be chosen which modulates the expression of the inserted gene sequences, or modifies and processes the gene product in the specific fashion desired. Expression from certain promoters can be elevated in the presence of certain inducers; thus expression of the genetically engineered polypeptide may be controlled. Furthermore, different host cells have characteristics and specific mechanisms for the translational and post-translational processing and modification (e.g., phosphorylation, cleavage) of proteins. Appropriate cell lines can be chosen to ensure the desired modifications and processing of the foreign protein expressed.

[0219] Introduction of the nucleic acids and nucleic acid constructs of the invention into the host cell can be effected by calcium phosphate transfection, DEAE-dextran mediated transfection, cationic lipid-mediated transfection, electroporation, transduction, infection, or other methods. Such methods are described in many standard laboratory manuals, such as Davis et al., Basic Methods In Molecular Biology (1986). It is specifically contemplated that the polypeptides of the present invention may in fact be expressed by a host cell lacking a recombinant vector.

[0220] In addition to encompassing host cells containing the vector constructs discussed herein, the invention also encompasses primary, secondary, and immortalized host cells of vertebrate origin, particularly mammalian origin, that have been engineered to delete or replace endogenous genetic material (e.g., reproductive system antigen coding sequence), and/or to include genetic material (e.g., heterologous polynucleotide sequences) that is operably associated with reproductive system associated polynucleotides of the invention, and which activates, alters, and/or amplifies endogenous reproductive system associated polynucleotides. For example, techniques known in the art may be used to operably associate heterologous control regions (e.g., promoter and/or enhancer) and endogenous reproductive system associated polynucleotide sequences via homologous recombination (see, e.g., U.S. Pat. No. 5,641,670, issued Jun. 24, 1997; International Publication Number WO 96/29411; International Publication Number WO 94/12650; Koller et al., Proc. Natl. Acad. Sci. USA 86:8932-8935 (1989); and Zijlstra et al., Nature 342:435-438 (1989), the disclosures of each of which are incorporated by reference in their entireties).

[0221] Polypeptides of the present invention can also be recovered from: products purified from natural sources, including bodily fluids, tissues and cells, whether directly isolated or cultured; products of chemical synthetic procedures; and products produced by recombinant techniques from a prokaryotic or eukaryotic host, including, for example, bacterial, yeast, higher plant, insect, and mammalian cells. Depending upon the host employed in a recombinant production procedure, the polypeptides of the present invention may be glycosylated or may be non-glycosylated. In addition, polypeptides of the invention may also include an initial modified methionine residue, in some cases as a result of host-mediated processes. Thus, it is well known in the art that the N-terminal methionine encoded by the translation initiation codon generally is removed with high efficiency from any protein after translation in all eukaryotic cells. While the N-terminal methionine on most proteins also is efficiently removed in most prokaryotes, for some proteins, this prokaryotic removal process is inefficient, depending on the nature of the amino acid to which the N-terminal methionine is covalently linked.

[0222] In one embodiment, the yeast Pichia pastoris is used to express polypeptides of the invention in a eukaryotic system. Pichia pastoris is a methylotrophic yeast which can metabolize methanol as its sole carbon source. A main step in the methanol metabolization pathway is the oxidation of methanol to formaldehyde using O₂. This reaction is catalyzed by the enzyme alcohol oxidase. In order to metabolize methanol as its sole carbon source, Pichia pastoris must generate high levels of alcohol oxidase due, in part, to the relatively low affinity of alcohol oxidase for O₂. Consequently, in a growth medium depending on methanol as a main carbon source, the promoter region of one of the two alcohol oxidase genes (AOX1) is highly active. In the presence of methanol, alcohol oxidase produced from the AOX1 gene comprises up to approximately 30% of the total soluble protein in Pichia pastoris. See, Ellis, S. B., et al., Mol. Cell. Biol. 5:1111-21 (1985); Koutz, P. J, et al., Yeast 5:167-77 (1989); Tschopp, J. F., et al., Nucl. Acids Res. 15:3859-76 (1987). Thus, a heterologous coding sequence, such as, for example, a polynucleotide of the present invention, under the transcriptional regulation of all or part of the AOX1 regulatory sequence is expressed at exceptionally high levels in Pichia yeast grown in the presence of methanol.

[0223] In one example, the plasmid vector pPIC9K is used to express DNA encoding a polypeptide of the invention, as set forth herein, in a Pichea yeast system essentially as described in “Pichia Protocols: Methods in Molecular Biology,” D.R. Higgins and J. Cregg, eds. The Humana Press, Totowa, N.J., 1998. This expression vector allows expression and secretion of a polypeptide of the invention by virtue of the strong AOX1 promoter linked to the Pichia pastoris alkaline phosphatase (PHO) secretory signal peptide (i.e., leader) located upstream of a multiple cloning site.

[0224] Many other yeast vectors could be used in place of pPIC9K, such as, pYES2, pYD1, pTEF1/Zeo, pYES2/GS, pPICZ, pGAPZ, pGAPZalpha, pPIC9, pPIC3.5, pHIL-D2, pHIL-S1, pPIC3.5K, and PAO815, as one skilled in the art would readily appreciate, as long as the proposed expression construct provides appropriately located signals for transcription, translation, secretion (if desired), and the like, including an in-frame AUG as required.

[0225] In another embodiment, high-level expression of a heterologous coding sequence, such as, for example, a polynucleotide of the present invention, may be achieved by cloning the heterologous polynucleotide of the invention into an expression vector such as, for example, pGAPZ or pGAPZalpha, and growing the yeast culture in the absence of methanol.

[0226] In addition to encompassing host cells containing the vector constructs discussed herein, the invention also encompasses primary, secondary, and immortalized host cells of vertebrate origin, particularly mammalian origin, that have been engineered to delete or replace endogenous genetic material (e.g., coding sequence), and/or to include genetic material (e.g., heterologous polynucleotide sequences) that is operably associated with polynucleotides of the invention, and which activates, alters, and/or amplifies endogenous polynucleotides. For example, techniques known in the art may be used to operably associate heterologous control regions (e.g., promoter and/or enhancer) and endogenous polynucleotide sequences via homologous recombination (see, e.g., U.S. Pat. No. 5,641,670, issued Jun. 24, 1997; International Publication No. WO 96/29411, published Sep. 26, 1996; International Publication No. WO 94/12650, published August 4, 1994; Koller et al., Proc. Natl. Acad. Sci. USA 86:8932-8935 (1989); and Zijlstra et al., Nature 342:435-438 (1989), the disclosures of each of which are incorporated by reference in their entireties).

[0227] In addition, polypeptides of the invention can be chemically synthesized using techniques known in the art (e.g., see Creighton, 1983, Proteins: Structures and Molecular Principles, W. H. Freeman & Co., N.Y., and Hunkapiller et al., Nature, 310:105-111 (1984)). For example, a polypeptide corresponding to a fragment of a polypeptide can be synthesized by use of a peptide synthesizer. Furthermore, if desired, nonclassical amino acids or chemical amino acid analogs can be introduced as a substitution or addition into the polypeptide sequence. Non-classical amino acids include, but are not limited to, to the D-isomers of the common amino acids, 2,4-diaminobutyric acid, a-amino isobutyric acid, 4-aminobutyric acid, Abu, 2-amino butyric acid, g-Abu, e-Ahx, 6-amino hexanoic acid, Aib, 2-amino isobutyric acid, 3-amino propionic acid, omithine, norleucine, norvaline, hydroxyproline, sarcosine, citrulline, homocitrulline, cysteic acid, t-butylglycine, t-butylalanine, phenylglycine, cyclohexylalanine, b-alanine, fluoro-amino acids, designer amino acids such as b-methyl amino acids, Ca-methyl amino acids, Na-methyl amino acids, and amino acid analogs in general. Furthermore, the amino acid can be D (dextrorotary) or L (levorotary).

[0228] The invention encompasses polypeptides of the present invention which are differentially modified during or after translation, e.g., by glycosylation, acetylation, phosphorylation, amidation, derivatization by known protecting/blocking groups, proteolytic cleavage, linkage to an antibody molecule or other cellular ligand, etc. Any of numerous chemical modifications may be carried out by known techniques, including but not limited, to specific chemical cleavage by cyanogen bromide, trypsin, chymotrypsin, papain, V8 protease, NaBH₄; acetylation, formylation, oxidation, reduction; metabolic synthesis in the presence of tunicamycin; etc.

[0229] Additional post-translational modifications encompassed by the invention include, for example, e.g., N-linked or O-linked carbohydrate chains, processing of N-terminal or C-terminal ends), attachment of chemical moieties to the amino acid backbone, chemical modifications of N-linked or O-linked carbohydrate chains, and addition or deletion of an N-terminal methionine residue as a result of procaryotic host cell expression. The polypeptides may also be modified with a detectable label, such as an enzymatic, fluorescent, isotopic or affinity label to allow for detection and isolation of the protein.

[0230] Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, beta-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin; and examples of suitable radioactive material include iodine (¹²¹I, ¹²³I, ¹²⁵I, ¹³¹I), carbon (¹⁴C), sulfur (³⁵S), tritium (³H), indium (¹¹¹In, ¹¹²In, ^(113m)In, ^(115m)In), technetium (⁹⁹Tc,^(99M)Tc), thallium (²⁰¹Ti), gallium (⁶⁸Ga, ⁶⁷Ga), palladium (¹⁰³Pd), molybdenum (⁹⁹Mo), xenon (¹³³ Xe), fluorine (¹⁸F), ¹⁵³Sm, ¹⁷⁷Lu, ¹⁵⁹Gd, ¹⁴⁹Pm, ¹⁴⁰La, ¹⁷⁵Yb, ¹⁶⁶Ho, ⁹⁰Y, ⁴⁷Sc, ¹⁸⁶Re, ¹⁸⁸Re, ¹⁴²Pr ¹⁰⁵Rh, and ⁹⁷Ru.

[0231] In specific embodiments, a polypeptide of the present invention or fragment or variant thereof is attached to macrocyclic chelators that associate with radiometal ions, including but not limited to, ¹⁷⁷Lu, ⁹⁰y, ¹⁶⁶Ho, and ¹⁵³Sm, to polypeptides. In a preferred embodiment, the radiometal ion associated with the macrocyclic chelators is 111In. In another preferred embodiment, the radiometal ion associated with the macrocyclic chelator is ⁹⁰Y. In specific embodiments, the macrocyclic chelator is 1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetraacetic acid (DOTA). In other specific embodiments, DOTA is attached to an antibody of the invention or fragment thereof via a linker molecule. Examples of linker molecules useful for conjugating DOTA to a polypeptide are commonly known in the art—see, for example, DeNardo et al., Clin Cancer Res. 4(10):2483-90 (1998); Peterson et al., Bioconjug. Chem. 10(4):553-7 (1999); and Zimmerman et al, Nucl. Med. Biol. 26(8):943-50 (1999); which are hereby incorporated by reference in their entirety.

[0232] As mentioned, the reproductive system associated proteins of the invention may be modified by either natural processes, such as posttranslational processing, or by chemical modification techniques which are well known in the art. It will be appreciated that the same type of modification may be present in the same or varying degrees at several sites in a given reproductive system associated polypeptide. Reproductive system associated polypeptides may be branched, for example, as a result of ubiquitination, and they may be cyclic, with or without branching. Cyclic, branched, and branched cyclic reproductive system associated polypeptides may result from posttranslation natural processes or may be made by synthetic methods. Modifications include acetylation, acylation, ADP-ribosylation, amidation, covalent attachment of flavin, covalent attachment of a heme moiety, covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent attachment of phosphotidylinositol, cross-linking, cyclization, disulfide bond formation, demethylation, formation of covalent cross-links, formation of cysteine, formation of pyroglutamate, formylation, gamma-carboxylation, glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, pegylation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer-RNA mediated addition of amino acids to proteins such as arginylation, and ubiquitination. (See, for instance, PROTEINS—STRUCTURE AND MOLECULAR PROPERTIES, 2nd Ed., T. E. Creighton, W. H. Freeman and Company, New York (1993); POSTTRANSLATIONAL COVALENT MODIFICATION OF PROTEINS, B. C. Johnson, Ed., Academic Press, New York, pgs. 1-12 (1983); Seifter et al., Meth. Enzymol. 182:626-646 (1990); Rattan et al., Ann. N.Y. Acad. Sci. 663:48-62 (1992)).

[0233] Also provided by the invention are chemically modified derivatives of the polypeptides of the invention which may provide additional advantages such as increased solubility, stability and circulating time of the polypeptide, or decreased immunogenicity (see U.S. Pat. No. 4,179,337). The chemical moieties for derivitization may be selected from water soluble polymers such as polyethylene glycol, ethylene glycol/propylene glycol copolymers, carboxymethylcellulose, dextran, polyvinyl alcohol and the like. The polypeptides may be modified at random positions within the molecule, or at predetermined positions within the molecule and may include one, two, three or more attached chemical moieties.

[0234] The polymer may be of any molecular weight, and may be branched or unbranched. For polyethylene glycol, the preferred molecular weight is between about 1 kDa and about 100 kDa (the term “about” indicating that in preparations of polyethylene glycol, some molecules will weigh more, some less, than the stated molecular weight) for ease in handling and manufacturing. Other sizes may be used, depending on the desired therapeutic profile (e.g., the duration of sustained release desired, the effects, if any on biological activity, the ease in handling, the degree or lack of antigenicity and other known effects of the polyethylene glycol to a therapeutic protein or analog). For example, the polyethylene glycol may have an average molecular weight of about 200, 500, 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000, 5500, 6000, 6500, 7000, 7500, 8000, 8500, 9000, 9500, 10,000, 10,500, 11,000, 11,500, 12,000, 12,500, 13,000, 13,500, 14,000, 14,500, 15,000, 15,500, 16,000, 16,500, 17,000, 17,500, 18,000, 18,500, 19,000, 19,500, 20,000, 25,000, 30,000, 35,000, 40,000, 50,000, 55,000, 60,000, 65,000, 70,000, 75,000, 80,000, 85,000, 90,000, 95,000, or 100,000 kDa.

[0235] As noted above, the polyethylene glycol may have a branched structure. Branched polyethylene glycols are described, for example, in U.S. Pat. No. 5,643,575; Morpurgo et al., Appl. Biochem. Biotechnol. 56:59-72 (1996); Vorobjev et al., Nucleosides Nucleotides 18:2745-2750 (1999); and Caliceti et al., Bioconjug. Chem. 10:638-646 (1999), the disclosures of each of which are incorporated herein by reference.

[0236] The polyethylene glycol molecules (or other chemical moieties) should be attached to the protein with consideration of effects on functional or antigenic domains of the protein. There are a number of attachment methods available to those skilled in the art, such as, for example, the method disclosed in EP 0 401 384 (coupling PEG to G-CSF), herein incorporated by reference; see also Malik et al., Exp. Hematol. 20:1028-1035 (1992), reporting pegylation of GM-CSF using tresyl chloride. For example, polyethylene glycol may be covalently bound through amino acid residues via a reactive group, such as a free amino or carboxyl group. Reactive groups are those to which an activated polyethylene glycol molecule may be bound. The amino acid residues having a free amino group may include lysine residues and the N-terminal amino acid residues; those having a free carboxyl group may include aspartic acid residues glutamic acid residues and the C-terminal amino acid residue. Sulfhydryl groups may also be used as a reactive group for attaching the polyethylene glycol molecules. Preferred for therapeutic purposes is attachment at an amino group, such as attachment at the N-terminus or lysine group.

[0237] As suggested above, polyethylene glycol may be attached to proteins via linkage to any of a number of amino acid residues. For example, polyethylene glycol can be linked to proteins via covalent bonds to lysine, histidine, aspartic acid, glutamic acid, or cysteine residues. One or more reaction chemistries may be employed to attach polyethylene glycol to specific amino acid residues (e.g., lysine, histidine, aspartic acid, glutamic acid, or cysteine) of the protein or to more than one type of amino acid residue (e.g., lysine, histidine, aspartic acid, glutamic acid, cysteine and combinations thereof) of the protein.

[0238] One may specifically desire proteins chemically modified at the N-terminus. Using polyethylene glycol as an illustration of the present composition, one may select from a variety of polyethylene glycol molecules (by molecular weight, branching, etc.), the proportion of polyethylene glycol molecules to protein (polypeptide) molecules in the reaction mix, the type of pegylation reaction to be performed, and the method of obtaining the selected N-terminally pegylated protein. The method of obtaining the N-terminally pegylated preparation (i.e., separating this moiety from other monopegylated moieties if necessary) may be by purification of the N-terminally pegylated material from a population of pegylated protein molecules. Selective proteins chemically modified at the N-terminus modification may be accomplished by reductive alkylation which exploits differential reactivity of different types of primary amino groups (lysine versus the N-terminal) available for derivatization in a particular protein. Under the appropriate reaction conditions, substantially selective derivatization of the protein at the N-terminus with a carbonyl group containing polymer is achieved.

[0239] As indicated above, pegylation of the proteins of the invention may be accomplished by any number of means. For example, polyethylene glycol may be attached to the protein either directly or by an intervening linker. Linkerless systems for attaching polyethylene glycol to proteins are described in Delgado et al., Crit. Rev. Thera. Drug Carrier Sys. 9:249-304 (1992); Francis et al., Intern. J. of Hematol. 68:1-18 (1998); U.S. Pat. No. 4,002,531; U.S. Pat. No. 5,349,052; WO 95/06058; and WO 98/32466, the disclosures of each of which are incorporated herein by reference.

[0240] One system for attaching polyethylene glycol directly to amino acid residues of proteins without an intervening linker employs tresylated MPEG, which is produced by the modification of monmethoxy polyethylene glycol (MPEG) using tresylchloride (ClSO₂CH₂CF₃). Upon reaction of protein with tresylated MPEG, polyethylene glycol is directly attached to amine groups of the protein. Thus, the invention includes protein-polyethylene glycol conjugates produced by reacting proteins of the invention with a polyethylene glycol molecule having a 2,2,2-trifluoreothane sulphonyl group.

[0241] Polyethylene glycol can also be attached to proteins using a number of different intervening linkers. For example, U.S. Pat. No. 5,612,460, the entire disclosure of which is incorporated herein by reference, discloses urethane linkers for connecting polyethylene glycol to proteins. Protein-polyethylene glycol conjugates wherein the polyethylene glycol is attached to the protein by a linker can also be produced by reaction of proteins with compounds such as MPEG-succinimidylsuccinate, MPEG activated with 1,1′-carbonyldiimidazole, MPEG-2,4,5-trichloropenylcarbonate, MPEG-p-nitrophenolcarbonate, and various MPEG-succinate derivatives. A number of additional polyethylene glycol derivatives and reaction chemistries for attaching polyethylene glycol to proteins are described in International Publication No. WO 98/32466, the entire disclosure of which is incorporated herein by reference. Pegylated protein products produced using the reaction chemistries set out herein are included within the scope of the invention.

[0242] The number of polyethylene glycol moieties attached to each protein of the invention (i.e., the degree of substitution) may also vary. For example, the pegylated proteins of the invention may be linked, on average, to 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 15, 17, 20, or more polyethylene glycol molecules. Similarly, the average degree of substitution within ranges such as 1-3, 2-4, 3-5, 4-6, 5-7, 6-8, 7-9, 8-10, 9-11, 10-12, 11-13, 12-14, 13-15, 14-16, 15-17, 16-18, 17-19, or 18-20 polyethylene glycol moieties per protein molecule. Methods for determining the degree of substitution are discussed, for example, in Delgado et al., Crit. Rev. Thera. Drug Carrier Sys. 9:249-304 (1992).

[0243] The reproductive system associated polypeptides of the invention can be recovered and purified from chemical synthesis and recombinant cell cultures by standard methods which include, but are not limited to, ammonium sulfate or ethanol precipitation, acid extraction, anion or cation exchange chromatography, phosphocellulose chromatography, hydrophobic interaction chromatography, affinity chromatography, hydroxylapatite chromatography and lectin chromatography. Most preferably, high performance liquid chromatography (“HPLC”) is employed for purification. Well known techniques for refolding protein may be employed to regenerate active conformation when the polypeptide is denatured during isolation and/or purification.

[0244] Reproductive system associated polynucleotides and polypeptides may be used in accordance with the present invention for a variety of applications, particularly those that make use of the chemical and biological properties of reproductive system associated antigens. Among these are applications in the detection, prevention, diagnosis and/or treatment of diseases associated with the reproductive system, such as e.g., cancers of the reproductive system, tumors, injuries and trauma, infections, congenital defects, and diseases or disorders which result in infertility, complications with pregnancy, labor, or parturition, postpartum difficulties, and as listed below in the section entitled “Reproductive System Disorders”. Additional applications relate to diagnosis and to treatment of disorders of cells, tissues and organisms. These aspects of the invention are discussed further below.

[0245] In a preferred embodiment, polynucleotides expressed in a particular tissue type (see, e.g., Table 1A, column 7) are used to detect, diagnose, treat, prevent and/or prognose disorders associated with the tissue type.

[0246] The polypeptides of the invention may be in monomers or multimers (i.e., dimers, trimers, tetramers and higher multimers). Accordingly, the present invention relates to monomers and multimers of the polypeptides of the invention, their preparation, and compositions (preferably, Therapeutics) containing them. In specific embodiments, the polypeptides of the invention are monomers, dimers, trimers or tetramers. In additional embodiments, the multimers of the invention are at least dimers, at least trimers, or at least tetramers.

[0247] Multimers encompassed by the invention may be homomers or heteromers. As used herein, the term homomer refers to a multimer containing only polypeptides corresponding to a protein of the invention (e.g., the amino acid sequence of SEQ ID NO: Y, an amino acid sequence encoded by SEQ ID NO: X or the complement of SEQ ID NO: X, the amino acid sequence encoded by the portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2, and/or an amino acid sequence encoded by cDNA contained in Clone ID NO: Z (including fragments, variants, splice variants, and fusion proteins, corresponding to these as described herein)). These homomers may contain polypeptides having identical or different amino acid sequences. In a specific embodiment, a homomer of the invention is a multimer containing only polypeptides having an identical amino acid sequence. In another specific embodiment, a homomer of the invention is a multimer containing polypeptides having different amino acid sequences. In specific embodiments, the multimer of the invention is a homodimer (e.g., containing two polypeptides having identical or different amino acid sequences) or a homotrimer (e.g., containing three polypeptides having identical and/or different amino acid sequences). In additional embodiments, the homomeric multimer of the invention is at least a homodimer, at least a homotrimer, or at least a homotetramer.

[0248] As used herein, the term heteromer refers to a multimer containing two or more heterologous polypeptides (i.e., polypeptides of different proteins) in addition to the polypeptides of the invention. In a specific embodiment, the multimer of the invention is a heterodimer, a heterotrimer, or a heterotetramer. In additional embodiments, the heteromeric multimer of the invention is at least a heterodimer, at least a heterotrimer, or at least a heterotetramer.

[0249] Multimers of the invention may be the result of hydrophobic, hydrophilic, ionic and/or covalent associations and/or may be indirectly linked by, for example, liposome formation. Thus, in one embodiment, multimers of the invention, such as, for example, homodimers or homotrimers, are formed when polypeptides of the invention contact one another in solution. In another embodiment, heteromultimers of the invention, such as, for example, heterotrimers or heterotetramers, are formed when polypeptides of the invention contact antibodies to the polypeptides of the invention (including antibodies to the heterologous polypeptide sequence in a fusion protein of the invention) in solution. In other embodiments, multimers of the invention are formed by covalent associations with and/or between the polypeptides of the invention. Such covalent associations may involve one or more amino acid residues contained in the polypeptide sequence (e.g., that recited in SEQ ID NO: Y, encoded by the portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2, and/or encoded by the cDNA contained in Clone ID NO: Z). In one instance, the covalent associations are cross-linking between cysteine residues located within the polypeptide sequences which interact in the native (i.e., naturally occurring) polypeptide. In another instance, the covalent associations are the consequence of chemical or recombinant manipulation. Alternatively, such covalent associations may involve one or more amino acid residues contained in the heterologous polypeptide sequence in a fusion protein. In one example, covalent associations are between the heterologous sequence contained in a fusion protein of the invention (see, e.g., U.S. Pat. No. 5,478,925). In a specific example, the covalent associations are between the heterologous sequence contained in a Fc fusion protein of the invention (as described herein). In another specific example, covalent associations of fusion proteins of the invention are between heterologous polypeptide sequence from another protein that is capable of forming covalently associated multimers, such as for example, osteoprotegerin (see, e.g., International Publication NO: WO 98/49305, the contents of which are herein incorporated by reference in its entirety). In another embodiment, two or more polypeptides of the invention are joined through peptide linkers. Examples include those peptide linkers described in U.S. Pat. No. 5,073,627 (hereby incorporated by reference). Proteins comprising multiple polypeptides of the invention separated by peptide linkers may be produced using conventional recombinant DNA technology.

[0250] Another method for preparing multimer polypeptides of the invention involves use of polypeptides of the invention fused to a leucine zipper or isoleucine zipper polypeptide sequence. Leucine zipper and isoleucine zipper domains are polypeptides that promote multimerization of the proteins in which they are found. Leucine zippers were originally identified in several DNA-binding proteins (Landschulz et al., Science 240:1759, (1988)), and have since been found in a variety of different proteins. Among the known leucine zippers are naturally occurring peptides and derivatives thereof that dimerize or trimerize. Examples of leucine zipper domains suitable for producing soluble multimeric proteins of the invention are those described in PCT application WO 94/10308, hereby incorporated by reference. Recombinant fusion proteins comprising a polypeptide of the invention fused to a polypeptide sequence that dimerizes or trimerizes in solution are expressed in suitable host cells, and the resulting soluble multimeric fusion protein is recovered from the culture supernatant using techniques known in the art.

[0251] Trimeric polypeptides of the invention may offer the advantage of enhanced biological activity. Preferred leucine zipper moieties and isoleucine moieties are those that preferentially form trimers. One example is a leucine zipper derived from lung surfactant protein D (SPD), as described in Hoppe et al. (FEBS Letters 344:191, (1994)) and in U.S. patent application Ser. No. 08/446,922, hereby incorporated by reference. Other peptides derived from naturally occurring trimeric proteins may be employed in preparing trimeric polypeptides of the invention.

[0252] In another example, proteins of the invention are associated by interactions between Flag® polypeptide sequence contained in fusion proteins of the invention containing Flag® polypeptide sequence. In a further embodiment, proteins of the invention are associated by interactions between heterologous polypeptide sequence contained in Flag® fusion proteins of the invention and anti-Flag® antibody.

[0253] The multimers of the invention may be generated using chemical techniques known in the art. For example, polypeptides desired to be contained in the multimers of the invention may be chemically cross-linked using linker molecules and linker molecule length optimization techniques known in the art (see, e.g., U.S. Pat. No. 5,478,925, which is herein incorporated by reference in its entirety). Additionally, multimers of the invention may be generated using techniques known in the art to form one or more inter-molecule cross-links between the cysteine residues located within the sequence of the polypeptides desired to be contained in the multimer (see, e.g., U.S. Pat. No. 5,478,925, which is herein incorporated by reference in its entirety). Further, polypeptides of the invention may be routinely modified by the addition of cysteine or biotin to the C-terminus or N-terminus of the polypeptide and techniques known in the art may be applied to generate multimers containing one or more of these modified polypeptides (see, e.g., U.S. Pat. No. 5,478,925, which is herein incorporated by reference in its entirety). Additionally, techniques known in the art may be applied to generate liposomes containing the polypeptide components desired to be contained in the multimer of the invention (see, e.g., U.S. Pat. No. 5,478,925, which is herein incorporated by reference in its entirety).

[0254] Alternatively, multimers of the invention may be generated using genetic engineering techniques known in the art. In one embodiment, polypeptides contained in multimers of the invention are produced recombinantly using fusion protein technology described herein or otherwise known in the art (see, e.g., U.S. Pat. No. 5,478,925, which is herein incorporated by reference in its entirety). In a specific embodiment, polynucleotides coding for a homodimer of the invention are generated by ligating a polynucleotide sequence encoding a polypeptide of the invention to a sequence encoding a linker polypeptide and then further to a synthetic polynucleotide encoding the translated product of the polypeptide in the reverse orientation from the original C-terminus to the N-terminus (lacking the leader sequence) (see, e.g., U.S. Pat. No. 5,478,925, which is herein incorporated by reference in its entirety). In another embodiment, recombinant techniques described herein or otherwise known in the art are applied to generate recombinant polypeptides of the invention which contain a transmembrane domain (or hydrophobic or signal peptide) and which can be incorporated by membrane reconstitution techniques into liposomes (see, e.g., U.S. Pat. No. 5,478,925, which is herein incorporated by reference in its entirety).

[0255] Antibodies

[0256] Further polypeptides of the invention relate to antibodies and T-cell antigen receptors (TCR) which immunospecifically bind a polypeptide, polypeptide fragment, or variant of the invention (e.g., a polypeptide or fragment or variant of the amino acid sequence of SEQ ID NO: Y or a polypeptide encoded by the cDNA contained in Clone ID NO: Z, and/or an epitope, of the present invention) as determined by immunoassays well known in the art for assaying specific antibody-antigen binding. Antibodies of the invention include, but are not limited to, polyclonal, monoclonal, multispecific, human, humanized or chimeric antibodies, single chain antibodies, Fab fragments, F(ab′) fragments, fragments produced by a Fab expression library, anti-idiotypic (anti-Id) antibodies (including, e.g., anti-Id antibodies to antibodies of the invention), intracellularly-made antibodies (i.e., intrabodies), and epitope-binding fragments of any of the above. The term “antibody,” as used herein, refers to immunoglobulin molecules and immunologically active portions of immunoglobulin molecules, i.e., molecules that contain an antigen binding site that immunospecifically binds an antigen. The immunoglobulin molecules of the invention can be of any type (e.g., IgG, IgE, IgM, IgD, IgA and IgY), class (e.g., IgG1, IgG2, IgG3, IgG4, IgA1 and IgA2) or subclass of immunoglobulin molecule. In preferred embodiments, the immunoglobulin molecules of the invention are IgG1. In other preferred embodiments, the immunoglobulin molecules of the invention are IgG4.

[0257] Most preferably the antibodies are human antigen-binding antibody fragments of the present invention and include, but are not limited to, Fab, Fab′ and F(ab′)2, Fd, single-chain Fvs (scFv), single-chain antibodies, disulfide-linked Fvs (sdFv) and fragments comprising either a VL or VH domain. Antigen-binding antibody fragments, including single-chain antibodies, may comprise the variable region(s) alone or in combination with the entirety or a portion of the following: hinge region, CH1, CH2, and CH3 domains. Also included in the invention are antigen-binding fragments also comprising any combination of variable region(s) with a hinge region, CH1, CH2, and CH3 domains. The antibodies of the invention may be from any animal origin including birds and mammals. Preferably, the antibodies are human, murine (e.g., mouse and rat), donkey, ship rabbit, goat, guinea pig, camel, horse, or chicken. As used herein, “human” antibodies include antibodies having the amino acid sequence of a human immunoglobulin and include antibodies isolated from human immunoglobulin libraries or from animals transgenic for one or more human immunoglobulin and that do not express endogenous immunoglobulins, as described infra and, for example in, U.S. Pat. No. 5,939,598 by Kucherlapati et al.

[0258] The antibodies of the present invention may be monospecific, bispecific, trispecific or of greater multispecificity. Multispecific antibodies may be specific for different epitopes of a polypeptide of the present invention or may be specific for both a polypeptide of the present invention as well as for a heterologous epitope, such as a heterologous polypeptide or solid support material. See, e.g., PCT publications WO 93/17715; WO 92/08802; WO 91/00360; WO 92/05793; Tutt, et al., J. Immunol. 147:60-69 (1991); U.S. Pat. Nos. 4,474,893; 4,714,681; 4,925,648; 5,573,920; 5,601,819; Kostelny et al., J. Immunol. 148:1547-1553 (1992).

[0259] Antibodies of the present invention may be described or specified in terms of the epitope(s) or portion(s) of a polypeptide of the present invention which they recognize or specifically bind. The epitope(s) or polypeptide portion(s) may be specified as described herein, e.g., by N-terminal and C-terminal positions, or by size in contiguous amino acid residues, or listed in the Tables and Figures. Preferred epitopes of the invention include those shown in column 6 of Table 1A, as well as polynucleotides that encode these epitopes. Antibodies which specifically bind any epitope or polypeptide of the present invention may also be excluded. Therefore, the present invention includes antibodies that specifically bind polypeptides of the present invention, and allows for the exclusion of the same.

[0260] Antibodies of the present invention may also be described or specified in terms of their cross-reactivity. Antibodies that do not bind any other analog, ortholog, or homolog of a polypeptide of the present invention are included. Antibodies that bind polypeptides with at least 95%, at least 90%, at least 85%, at least 80%, at least 75%, at least 70%, at least 65%, at least 60%, at least 55%, and at least 50% identity (as calculated using methods known in the art and described herein) to a polypeptide of the present invention are also included in the present invention. In specific embodiments, antibodies of the present invention cross-react with murine, rat and/or rabbit homologs of human proteins and the corresponding epitopes thereof. Antibodies that do not bind polypeptides with less than 95%, less than 90%, less than 85%, less than 80%, less than 75%, less than 70%, less than 65%, less than 60%, less than 55%, and less than 50% identity (as calculated using methods known in the art and described herein) to a polypeptide of the present invention are also included in the present invention. In a specific embodiment, the above-described cross-reactivity is with respect to any single specific antigenic or immunogenic polypeptide, or combination(s) of 2, 3, 4, 5, or more of the specific antigenic and/or immunogenic polypeptides disclosed herein. Further included in the present invention are antibodies which bind polypeptides encoded by polynucleotides which hybridize to a polynucleotide of the present invention under stringent hybridization conditions (as described herein). Antibodies of the present invention may also be described or specified in terms of their binding affinity to a polypeptide of the invention. Preferred binding affinities include those with a dissociation constant or Kd less than 5×10⁻² M, 10⁻² M, 5×10⁻³ M, 10⁻³ M, 5×10⁻⁴ M, 10⁻⁴ M, 5×10⁻⁵ M, 10⁻⁵ M, 5×10⁻⁶ M, 10⁻⁶ M, 5×10⁻⁷ M, 10⁷ M, 5×10⁻⁸ M, 10⁻⁸ M, 5×10⁻⁹ M, 10⁻⁹ M, 5×10⁻¹⁰ M, 10⁻¹⁰ M 5×10⁻¹¹ M, 10⁻¹¹ M, 5×10⁻¹² M, 10⁻¹²M, 5×10⁻¹³ M, 10⁻¹³ M 5×10⁻¹⁴ M, 10⁻¹⁴ M, 5×10⁻¹⁵ M, 10⁻¹⁵ M.

[0261] The invention also provides antibodies that competitively inhibit binding of an antibody to an epitope of the invention as determined by any method known in the art for determining competitive binding, for example, the immunoassays described herei-n. In preferred embodiments, the antibody competitively inhibits binding to the epitope by at least 95%, at least 90%, at least 85%, at least 80%, at least 75%, at least 70%, at least 60%, or at least 50%.

[0262] Antibodies of the present invention may act as agonists or antagonists of the polypeptides of the present invention. For example, the present invention includes antibodies which disrupt the receptor/ligand interactions with the polypeptides of the invention either partially or fully. Preferably, antibodies of the present invention bind an antigenic epitope disclosed herein, or a portion thereof. The invention features both receptor-specific antibodies and ligand-specific antibodies. The invention also features receptor-specific antibodies which do not prevent ligand binding but prevent receptor activation. Receptor activation (i.e., signaling) may be determined by techniques described herein or otherwise known in the art. For example, receptor activation can be determined by detecting the phosphorylation (e.g., tyrosine or serine/threonine) of the receptor or its substrate by immunoprecipitation followed by western blot analysis (for example, as described supra). In specific embodiments, antibodies are provided that inhibit ligand activity or receptor activity by at least 95%, at least 90%, at least 85%, at least 80%, at least 75%, at least 70%, at least 60%, or at least 50% of the activity in absence of the antibody.

[0263] The invention also features receptor-specific antibodies which both prevent ligand binding and receptor activation as well as antibodies that recognize the receptor-ligand complex, and, preferably, do not specifically recognize the unbound receptor or the unbound ligand. Likewise, included in the invention are neutralizing antibodies which bind the ligand and prevent binding of the ligand to the receptor, as well as antibodies which bind the ligand, thereby preventing receptor activation, but do not prevent the ligand from binding the receptor. Further included in the invention are antibodies which activate the receptor. These antibodies may act as receptor agonists, i.e., potentiate or activate either all or a subset of the biological activities of the ligand-mediated receptor activation, for example, by inducing dimerization of the receptor. The antibodies may be specified as agonists, antagonists or inverse agonists for biological activities comprising the specific biological activities of the peptides of the invention disclosed herein. The above antibody agonists can be made using methods known in the art. See, e.g., PCT publication WO 96/40281; U.S. Pat. No. 5,811,097; Deng et al., Blood 92(6):1981-1988 (1998); Chen et al., Cancer Res. 58(16):3668-3678 (1998); Harrop et al., J. Immunol. 161(4):1786-1794 (1998); Zhu et al., Cancer Res. 58(15):3209-3214 (1998); Yoon et al., J. Immunol. 160(7):3170-3179 (1998); Prat et al., J. Cell. Sci. 111(Pt2):237-247 (1998); Pitard et al., J. Immunol. Methods 205(2):177-190 (1997); Liautard et al., Cytokine 9(4):233-241 (1997); Carlson et al., J. Biol. Chem. 272(17):11295-11301 (1997); Taryman et al., Neuron 14(4):755-762 (1995); Muller et al., Structure 6(9):1153-1167 (1998); Bartunek et al., Cytokine 8(1):14-20 (1996) (which are all incorporated by reference herein in their entireties).

[0264] Antibodies of the present invention may be used, for example, to purify, detect, and target the polypeptides of the present invention, including both in vitro and in vivo diagnostic and therapeutic methods. For example, the antibodies have utility in immunoassays for qualitatively and quantitatively measuring levels of the polypeptides of the present invention in biological samples. See, e.g., Harlow et al., Antibodies: A Laboratory Manual, (Cold Spring Harbor Laboratory Press, 2nd ed. 1988); incorporated by reference herein in its entirety.

[0265] As discussed in more detail below, the antibodies of the present invention may be used either alone or in combination with other compositions. The antibodies may further be recombinantly fused to a heterologous polypeptide at the N- or C-terminus or chemically conjugated (including covalent and non-covalent conjugations) to polypeptides or other compositions. For example, antibodies of the present invention may be recombinantly fused or conjugated to molecules useful as labels in detection assays and effector molecules such as heterologous polypeptides, drugs, radionuclides, or toxins. See, e.g., PCT publications WO 92/08495; WO 91/14438; WO 89/12624; U.S. Pat. No. 5,314,995; and EP 396,387; the disclosures of which are incorporated herein by reference in their entireties.

[0266] The antibodies of the invention include derivatives that are modified, i.e., by the covalent attachment of any type of molecule to the antibody such that covalent attachment does not prevent the antibody from generating an anti-idiotypic response. For example, but not by way of limitation, the antibody derivatives include antibodies that have been modified, e.g., by glycosylation, acetylation, pegylation, phosphylation, amidation, derivatization by known protecting/blocking groups, proteolytic cleavage, linkage to a cellular ligand or other protein, etc. Any of numerous chemical modifications may be carried out by known techniques, including, but not limited to specific chemical cleavage, acetylation, formylation, metabolic synthesis of tunicamycin, etc. Additionally, the derivative may contain one or more non-classical amino acids.

[0267] The antibodies of the present invention may be generated by any suitable method known in the art. Polyclonal antibodies to an antigen-of-interest can be produced by various procedures well known in the art. For example, a polypeptide of the invention can be administered to various host animals including, but not limited to, rabbits, mice, rats, etc. to induce the production of sera containing polyclonal antibodies specific for the antigen. Various adjuvants may be used to increase the immunological response, depending on the host species, and include but are not limited to, Freund's (complete and incomplete), mineral gels such as aluminum hydroxide, surface active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanins, dinitrophenol, and potentially useful human adjuvants such as BCG (bacille Calmette-Guerin) and corynebacterium parvum. Such adjuvants are also well known in the art.

[0268] Monoclonal antibodies can be prepared using a wide variety of techniques known in the art including the use of hybridoma, recombinant, and phage display technologies, or a combination thereof. For example, monoclonal antibodies can be produced using hybridoma techniques including those known in the art and taught, for example, in Harlow et al., Antibodies: A Laboratory Manual, (Cold Spring Harbor Laboratory Press, 2nd ed. 1988); Hammerling, et al., in: Monoclonal Antibodies and T-Cell Hybridomas 563-681 (Elsevier, N.Y., 1981) (said references incorporated by reference in their entireties). The term “monoclonal antibody” as used herein is not limited to antibodies produced through hybridoma technology. The term “monoclonal antibody” refers to an antibody that is derived from a single clone, including any eukaryotic, prokaryotic, or phage clone, and not the method by which it is produced.

[0269] Methods for producing and screening for specific antibodies using hybridoma technology are routine and well known in the art and are discussed in detail in the Examples. In a non-limiting example, mice can be immunized with a polypeptide of the invention or a cell expressing such peptide. Once an immune response is detected, e.g., antibodies specific for the antigen are detected in the mouse serum, the mouse spleen is harvested and splenocytes isolated. The splenocytes are then fused by well known techniques to any suitable myeloma cells, for example cells from cell line SP20 available from the ATCC. Hybridomas are selected and cloned by limited dilution. The hybridoma clones are then assayed by methods known in the art for cells that secrete antibodies capable of binding a polypeptide of the invention. Ascites fluid, which generally contains high levels of antibodies, can be generated by immunizing mice with positive hybridoma clones.

[0270] Accordingly, the present invention provides methods of generating monoclonal antibodies as well as antibodies produced by the method comprising culturing a hybridoma cell secreting an antibody of the invention wherein, preferably, the hybridoma is generated by fusing splenocytes isolated from a mouse immunized with an antigen of the invention with myeloma cells and then screening the hybridomas resulting from the fusion for hybridoma clones that secrete an antibody able to bind a polypeptide of the invention.

[0271] Another well known method for producing both polyclonal and monoclonal human B cell lines is transformation using Epstein Barr Virus (EBV). Protocols for generating EBV-transformed B cell lines are commonly known in the art, such as, for example, the protocol outlined in Chapter 7.22 of Current Protocols in Immunology, Coligan et al., Eds., 1994, John Wiley & Sons, NY, which is hereby incorporated in its entirety by reference herein. The source of B cells for transformation is commonly human peripheral blood, but B cells for transformation may also be derived from other sources including, but not limited to, lymph nodes, tonsil, spleen, tumor tissue, and infected tissues. Tissues are generally made into single cell suspensions prior to EBV transformation. Additionally, steps may be taken to either physically remove or inactivate T cells (e.g., by treatment with cyclosporin A) in B cell-containing samples, because T cells from individuals seropositive for anti-EBV antibodies can suppress B cell immortalization by EBV.

[0272] In general, the sample containing human B cells is innoculated with EBV, and cultured for 3-4 weeks. A typical source of EBV is the culture supernatant of the B95-8 cell line (ATCC #VR-1492). Physical signs of EBV transformation can generally be seen towards the end of the 3-4 week culture period. By phase-contrast microscopy, transformed cells may appear large, clear, hairy and tend to aggregate in tight clusters of cells. Initially, EBV lines are generally polyclonal. However, over prolonged periods of cell cultures, EBV lines may become monoclonal or polyclonal as a result of the selective outgrowth of particular B cell clones. Alternatively, polyclonal EBV transformed lines may be subcloned (e.g., by limiting dilution culture) or fused with a suitable fusion partner and plated at limiting dilution to obtain monoclonal B cell lines. Suitable fusion partners for EBV transformed cell lines include mouse myeloma cell lines (e.g., SP2/0, X63-Ag8.653), heteromyeloma cell lines (human x mouse; e.g, SPAM-8, SBC-H20, and CB-F7), and human cell lines (e.g., GM 1500, SKO-007, RPMI 8226, and KR-4). Thus, the present invention also provides a method of generating polyclonal or monoclonal human antibodies against polypeptides of the invention or fragments thereof, comprising EBV-transformation of human B cells.

[0273] Antibody fragments which recognize specific epitopes may be generated by known techniques. For example, Fab and F(ab′)2 fragments of the invention may be produced by proteolytic cleavage of immunoglobulin molecules, using enzymes such as papain (to produce Fab fragments) or pepsin (to produce F(ab′)2 fragments). F(ab′)2 fragments contain the variable region, the light chain constant region and the CHI domain of the heavy chain. For example, the antibodies of the present invention can also be generated using various phage display methods known in the art and as discussed in detail in the Examples (e.g., Example 10). In phage display methods, functional antibody domains are displayed on the surface of phage particles which carry the polynucleotide sequences encoding them. In a particular embodiment, such phage can be utilized to display antigen binding domains expressed from a repertoire or combinatorial antibody library (e.g., human or murine). Phage expressing an antigen binding domain that binds the antigen of interest can be selected or identified with antigen, e.g., using labeled antigen or antigen bound or captured to a solid surface or bead. Phage used in these methods are typically filamentous phage including fd and M13 binding domains expressed from phage with Fab, Fv or disulfide stabilized Fv antibody domains recombinantly fused to either the phage gene III or gene VIII protein. Examples of phage display methods that can be used to make the antibodies of the present invention include those disclosed in Brinkman et al., J. Imnunol. Methods 182:41-50 (1995); Ames et al., J. Immunol. Methods 184:177-186 (1995); Kettleborough et al., Eur. J. Immunol. 24:952-958 (1994); Persic et al., Gene 187 9-18 (1997); Burton et al., Advances in Immunology 57:191-280 (1994); PCT application No. PCT/GB91/01134; PCT publications WO 90/02809; WO 91/10737; WO 92/01047; WO 92/18619; WO 93/11236; WO 95/15982; WO 95/20401; and U.S. Pat. Nos. 5,698,426; 5,223,409; 5,403,484; 5,580,717; 5,427,908; 5,750,753; 5,821,047; 5,571,698; 5,427,908; 5,516,637; 5,780,225; 5,658,727; 5,733,743 and 5,969,108; each of which is incorporated herein by reference in its entirety.

[0274] As described in the above references, after phage selection, the antibody coding regions from the phage can be isolated and used to generate whole antibodies, including human antibodies, or any other desired antigen binding fragment, and expressed in any desired host, including mammalian cells, insect cells, plant cells, yeast, and bacteria, e.g., as described in detail below. For example, techniques to recombinantly produce Fab, Fab′ and F(ab′)2 fragments can also be employed using methods known in the art such as those disclosed in PCT publication WO 92/22324; Mullinax et al., BioTechniques 12(6):864-869 (1992); and Sawai et al., AJRI 34:26-34 (1995); and Better et al., Science 240:1041-1043 (1988) (said references incorporated by reference in their entireties).

[0275] Examples of techniques which can be used to produce single-chain Fvs and antibodies include those described in U.S. Patents 4,946,778 and 5,258,498; Huston et al., Methods in Enzymology 203:46-88 (1991); Shu et al., PNAS 90:7995-7999 (1993); and Skerra et al., Science 240:1038-1040 (1988). For some uses, including in vivo use of antibodies in humans and in vitro detection assays, it may be preferable to use chimeric, humanized, or human antibodies. A chimeric antibody is a molecule in which different portions of the antibody are derived from different animal species, such as antibodies having a variable region derived from a murine monoclonal antibody and a human immunoglobulin constant region. Methods for producing chimeric antibodies are known in the art. See e.g., Morrison, Science 229:1202 (1985); Oi et al., BioTechniques 4:214 (1986); Gillies et al., (1989) J. Immunol. Methods 125:191-202; U.S. Pat. Nos. 5,807,715; 4,816,567; and 4,816397, which are incorporated herein by reference in their entirety. Humanized antibodies are antibody molecules from non-human species antibody that binds the desired antigen having one or more complementarity determining regions (CDRs) from the non-human species and a framework regions from a human immunoglobulin molecule. Often, framework residues in the human framework regions will be substituted with the corresponding residue from the CDR donor antibody to alter, preferably improve, antigen binding. These framework substitutions are identified by methods well known in the art, e.g., by modeling of the interactions of the CDR and framework residues to identify framework residues important for antigen binding and sequence comparison to identify unusual framework residues at particular positions. (See, e.g., Queen et al., U.S. Pat. No. 5,585,089; Riechmann et al., Nature 332:323 (1988), which are incorporated herein by reference in their entireties.) Antibodies can be humanized using a variety of techniques known in the art including, for example, CDR-grafting (EP 239,400; PCT publication WO 91/09967; U.S. Pat. Nos. 5,225,539; 5,530,101; and 5,585,089), veneering or resurfacing (EP 592,106; EP 519,596; Padlan, Molecular Immunology 28(4/5):489-498 (1991); Studnicka et al., Protein Engineering 7(6):805-814 (1994); Roguska. et al., PNAS 91:969-973 (1994)), and chain shuffling (U.S. Pat. No. 5,565,332).

[0276] Completely human antibodies are particularly desirable for therapeutic treatment of human patients. Human antibodies can be made by a variety of methods known in the art including phage display methods described above using antibody libraries derived from human immunoglobulin sequences. See also, U.S. Pat. Nos. 4,444,887 and 4,716,111; and PCT publications WO 98/46645, WO 98/50433, WO 98/24893, WO 98/16654, WO 96/34096, WO 96/33735, and WO 91/10741; each of which is incorporated herein by reference in its entirety.

[0277] Human antibodies can also be produced using transgenic mice which are incapable of expressing functional endogenous immunoglobulins, but which can express human immunoglobulin genes. For example, the human heavy and light chain immunoglobulin gene complexes may be introduced randomly or by homologous recombination into mouse embryonic stem cells. Alternatively, the human variable region, constant region, and diversity region may be introduced into mouse embryonic stem cells in addition to the human heavy and light chain genes. The mouse heavy and light chain immunoglobulin genes may be rendered non-functional separately or simultaneously with the introduction of human immunoglobulin loci by homologous recombination. In particular, homozygous deletion of the JH region prevents endogenous antibody production. The modified embryonic stem cells are expanded and microinjected into blastocysts to produce chimeric mice. The chimeric mice are then bred to produce homozygous offspring which express human antibodies. The transgenic mice are immunized in the normal fashion with a selected antigen, e.g., all or a portion of a polypeptide of the invention. Monoclonal antibodies directed against the antigen can be obtained from the immunized, transgenic mice using conventional hybridoma technology. The human immunoglobulin transgenes harbored by the transgenic mice rearrange during B cell differentiation, and subsequently undergo class switching and somatic mutation. Thus, using such a technique, it is possible to produce therapeutically useful IgG, IgA, IgM and IgE antibodies. For an overview of this technology for producing human antibodies, see Lonberg and Huszar, Int. Rev. Immunol. 13:65-93 (1995). For a detailed discussion of this technology for producing human antibodies and human monoclonal antibodies and protocols for producing such antibodies, see, e.g., PCT publications WO 98/24893; WO 92/01047; WO 96/34096; WO 96/33735; European Patent No. 0 598 877; U.S. Pat. Nos. 5,413,923; 5,625,126; 5,633,425; 5,569,825; 5,661,016; 5,545,806; 5,814,318; 5,885,793; 5,916,771; 5,939,598; 6,075,181 and 6,114,598, which are incorporated by reference herein in their entirety. In addition, companies such as Abgenix, Inc. (Freemont, Calif.) and Genpharm (San Jose, Calif.) can be engaged to provide human antibodies directed against a selected antigen using technology similar to that described above.

[0278] Completely human antibodies which recognize a selected epitope can be generated using a technique referred to as “guided selection.” In this approach a selected non-human monoclonal antibody, e.g., a mouse antibody, is used to guide the selection of a completely human antibody recognizing the same epitope. (Jespers et al., Bio/technology 12:899-903 (1988)).

[0279] Further, antibodies to the polypeptides of the invention can, in turn, be utilized to generate anti-idiotype antibodies that “mimic” polypeptides of the invention using techniques well known to those skilled in the art. (See, e.g., Greenspan & Bona, FASEB J. 7(5):437-444; (1989) and Nissinoff, J. Immunol. 147(8):2429-2438 (1991)). For example, antibodies which bind to and competitively inhibit polypeptide multimerization and/or binding of a polypeptide of the invention to a ligand can be used to generate anti-idiotypes that “mimic” the polypeptide multimerization and/or binding domain and, as a consequence, bind to and neutralize polypeptide and/or its ligand. Such neutralizing anti-idiotypes or Fab fragments of such anti-idiotypes can be used in therapeutic regimens to neutralize polypeptide ligand/receptor. For example, such anti-idiotypic antibodies can be used to bind a polypeptide of the invention and/or to bind its ligand(s)/receptor(s), and thereby block its biological activity. Alternatively, antibodies which bind to and enhance polypeptide multimerization and/or binding, and/or receptor/ligand multimerization, binding and/or signaling can be used to generate anti-idiotypes that function as agonists of a polypeptide of the invention and/or its ligand/receptor. Such agonistic anti-idiotypes or Fab fragments of such anti-idiotypes can be used in therapeutic regimens as agonists of the polypeptides of the invention or its ligand(s)/receptor(s). For example, such anti-idiotypic antibodies can be used to bind a polypeptide of the invention and/or to bind its ligand(s)/receptor(s), and thereby promote or enhance its biological activity.

[0280] Intrabodies of the invention can be produced using methods known in the art, such as those disclosed and reviewed in Chen et al., Hum. Gene Ther. 5:595-601 (1994); Marasco, W. A., Gene Ther. 4:11-15 (1997); Rondon and Marasco, Annu. Rev. Microbiol. 51:257-283 (1997); Proba et al., J. Mol. Biol. 275:245-253 (1998); Cohen et al., Oncogene 17:2445-2456 (1998); Ohage and Steipe, J. Mol. Biol. 291:1119-1128 (1999); Ohage et al., J. Mol. Biol. 291:1129-1134 (1999); Wirtz and Steipe, Protein Sci. 8:2245-2250 (1999); Zhu et al., J. Immunol. Methods 231:207-222 (1999); and references cited therein.

[0281] Polynucleotides Encoding Antibodies

[0282] The invention further provides polynucleotides comprising a nucleotide sequence encoding an antibody of the invention and fragments thereof. The invention also encompasses polynucleotides that hybridize under stringent or alternatively, under lower stringency hybridization conditions, e.g., as defined supra, to polynucleotides that encode an antibody, preferably, that specifically binds to a polypeptide of the invention, preferably, an antibody that binds to a polypeptide having the amino acid sequence of SEQ ID NO: Y, to a polypeptide encoded by a portion of SEQ ID NO: X as defined in columns 8 and 9 of Table 2, and/or to a polypeptide encoded by the cDNA contained in Clone ID NO: Z.

[0283] The polynucleotides may be obtained, and the nucleotide sequence of the polynucleotides determined, by any method known in the art. For example, if the nucleotide sequence of the antibody is known, a polynucleotide encoding the antibody may be assembled from chemically synthesized oligonucleotides (e.g., as described in Kutmeier et al., BioTechniques 17:242 (1994)), which, briefly, involves the synthesis of overlapping oligonucleotides containing portions of the sequence encoding the antibody, annealing and ligating of those oligonucleotides, and then amplification of the ligated oligonucleotides by PCR.

[0284] Alternatively, a polynucleotide encoding an antibody may be generated from nucleic acid from a suitable source. If a clone containing a nucleic acid encoding a particular antibody is not available, but the sequence of the antibody molecule is known, a nucleic acid encoding the immunoglobulin may be chemically synthesized or obtained from a suitable source (e.g., an antibody cDNA library, or a cDNA library generated from, or nucleic acid, preferably poly A+ RNA, isolated from, any tissue or cells expressing the antibody, such as hybridoma cells selected to express an antibody of the invention) by PCR amplification using synthetic primers hybridizable to the 3′ and 5′ ends of the sequence or by cloning using an oligonucleotide probe specific for the particular gene sequence to identify, e.g., a cDNA clone from a cDNA library that encodes the antibody. Amplified nucleic acids generated by PCR may then be cloned into replicable cloning vectors using any method well known in the art.

[0285] Once the nucleotide sequence and corresponding amino acid sequence of the antibody is determined, the nucleotide sequence of the antibody may be manipulated using methods well known in the art for the manipulation of nucleotide sequences, e.g., recombinant DNA techniques, site directed mutagenesis, PCR, etc. (see, for example, the techniques described in Sambrook et al., 1990, Molecular Cloning, A Laboratory Manual, 2d Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y. and Ausubel et al., eds., 1998, Current Protocols in Molecular Biology, John Wiley & Sons, NY, which are both incorporated by reference herein in their entireties ), to generate antibodies having a different amino acid sequence, for example to create amino acid substitutions, deletions, and/or insertions.

[0286] In a specific embodiment, the amino acid sequence of the heavy and/or light chain variable domains may be inspected to identify the sequences of the complementarity determining regions (CDRs) by methods that are well know in the art, e.g., by comparison to known amino acid sequences of other heavy and light chain variable regions to determine the regions of sequence hypervariability. Using routine recombinant DNA techniques, one or more of the CDRs may be inserted within framework regions, e.g., into human framework regions to humanize a non-human antibody, as described supra. The framework regions may be naturally occurring or consensus framework regions, and preferably human framework regions (see, e.g., Chothia et al., J. Mol. Biol. 278: 457-479 (1998) for a listing of human framework regions). Preferably, the polynucleotide generated by the combination of the framework regions and CDRs encodes an antibody that specifically binds a polypeptide of the invention. Preferably, as discussed supra, one or more amino acid substitutions may be made within the framework regions, and, preferably, the amino acid substitutions improve binding of the antibody to its antigen. Additionally, such methods may be used to make amino acid substitutions or deletions of one or more variable region cysteine residues participating in an intrachain disulfide bond to generate antibody molecules lacking one or more intrachain disulfide bonds. Other alterations to the polynucleotide are encompassed by the present invention and within the skill of the art.

[0287] In addition, techniques developed for the production of “chimeric antibodies” (Morrison et al., Proc. Natl. Acad. Sci. 81:851-855 (1984); Neuberger et al., Nature 312:604-608 (1984); Takeda et al., Nature 314:452-454 (1985)) by splicing genes from a mouse antibody molecule of appropriate antigen specificity together with genes from a human antibody molecule of appropriate biological activity can be used. As described supra, a chimeric antibody is a molecule in which different portions are derived from different animal species, such as those having a variable region derived from a murine mAb and a human immunoglobulin constant region, e.g., humanized antibodies.

[0288] Alternatively, techniques described for the production of single chain antibodies (U.S. Pat. No. 4,946,778; Bird, Science 242:423-42 (1988); Huston et al., Proc. Natl. Acad. Sci. USA 85:5879-5883 (1988); and Ward et al., Nature 334:544-54 (1989)) can be adapted to produce single chain antibodies. Single chain antibodies are formed by linking the heavy and light chain fragments of the Fv region via an amino acid bridge, resulting in a single chain polypeptide. Techniques for the assembly of functional Fv fragments in E. coli may also be used (Skerra et al., Science 242:1038-1041 (1988)).

[0289] Methods of Producing Antibodies

[0290] The antibodies of the invention can be produced by any method known in the art for the synthesis of antibodies, in particular, by chemical synthesis or preferably, by recombinant expression techniques. Methods of producing antibodies include, but are not limited to, hybridoma technology, EBV transformation, and other methods discussed herein as well as through the use recombinant DNA technology, as discussed below.

[0291] Recombinant expression of an antibody of the invention, or fragment, derivative or analog thereof, (e.g., a heavy or light chain of an antibody of the invention or a single chain antibody of the invention), requires construction of an expression vector containing a polynucleotide that encodes the antibody. Once a polynucleotide encoding an antibody molecule or a heavy or light chain of an antibody, or portion thereof (preferably containing the heavy or light chain variable domain), of the invention has been obtained, the vector for the production of the antibody molecule may be produced by recombinant DNA technology using techniques well known in the art. Thus, methods for preparing a protein by expressing a polynucleotide containing an antibody encoding nucleotide sequence are described herein. Methods which are well known to those skilled in the art can be used to construct expression vectors containing antibody coding sequences and appropriate transcriptional and translational control signals. These methods include, for example, in vitro recombinant DNA techniques, synthetic techniques, and in vivo genetic recombination. The invention, thus, provides replicable vectors comprising a nucleotide sequence encoding an antibody molecule of the invention, or a heavy or light chain thereof, or a heavy or light chain variable domain, operably linked to a promoter. Such vectors may include the nucleotide sequence encoding the constant region of the antibody molecule (see, e.g., PCT Publication WO 86/05807; PCT Publication WO 89/01036; and U.S. Pat. No. 5,122,464) and the variable domain of the antibody may be cloned into such a vector for expression of the entire heavy or light chain.

[0292] The expression vector is transferred to a host cell by conventional techniques and the transfected cells are then cultured by conventional techniques to produce an antibody of the invention. Thus, the invention includes host cells containing a polynucleotide encoding an antibody of the invention, or a heavy or light chain thereof, or a single chain antibody of the invention, operably linked to a heterologous promoter. In preferred embodiments for the expression of double-chained antibodies, vectors encoding both the heavy and light chains may be co-expressed in the host cell for expression of the entire immunoglobulin molecule, as detailed below.

[0293] A variety of host-expression vector systems may be utilized to express the antibody molecules of the invention. Such host-expression systems represent vehicles by which the coding sequences of interest may be produced and subsequently purified, but also represent cells which may, when transformed or transfected with the appropriate nucleotide coding sequences, express an antibody molecule of the invention in situ. These include but are not limited to microorganisms such as bacteria (e.g., E. coli, B. subtilis) transformed with recombinant bacteriophage DNA, plasmid DNA or cosmid DNA expression vectors containing antibody coding sequences; yeast (e.g., Saccharomyces, Pichia) transformed with recombinant yeast expression vectors containing antibody coding sequences; insect cell systems infected with recombinant virus expression vectors (e.g., baculovirus) containing antibody coding sequences; plant cell systems infected with recombinant virus expression vectors (e.g., cauliflower mosaic virus, CaMV; tobacco mosaic virus, TMV) or transformed with recombinant plasmid expression vectors (e.g., Ti plasmid) containing antibody coding sequences; or mammalian cell systems (e.g., COS, CHO, BHK, 293, 3T3 cells) harboring recombinant expression constructs containing promoters derived from the genome of mammalian cells (e.g., metallothionein promoter) or from mammalian viruses (e.g., the adenovirus late promoter; the vaccinia virus 7.5K promoter). Preferably, bacterial cells such as Escherichia coli, and more preferably, eukaryotic cells, especially for the expression of whole recombinant antibody molecule, are used for the expression of a recombinant antibody molecule. For example, mammalian cells such as Chinese hamster ovary cells (CHO), in conjunction with a vector such as the major intermediate early gene promoter element from human cytomegalovirus is an effective expression system for antibodies (Foecking et al., Gene 45:101 (1986); Cockett et al., Bio/Technology 8:2 (1990)).

[0294] In bacterial systems, a number of expression vectors may be advantageously selected depending upon the use intended for the antibody molecule being expressed. For example, when a large quantity of such a protein is to be produced, for the generation of pharmaceutical compositions of an antibody molecule, vectors which direct the expression of high levels of fusion protein products that are readily purified may be desirable. Such vectors include, but are not limited, to the E. coli expression vector pUR278 (Ruther et al., EMBO J. 2:1791 (1983)), in which the antibody coding sequence may be ligated individually into the vector in frame with the lac Z coding region so that a fusion protein is produced; pIN vectors (Inouye & Inouye, Nucleic Acids Res. 13:3101-3109 (1985); Van Heeke & Schuster, J. Biol. Chem. 24:5503-5509 (1989)); and the like. pGEX vectors may also be used to express foreign polypeptides as fusion proteins with glutathione S-transferase (GST). In general, such fusion proteins are soluble and can easily be purified from lysed cells by adsorption and binding to matrix glutathione-agarose beads followed by elution in the presence of free glutathione. The pGEX vectors are designed to include thrombin or factor Xa protease cleavage sites so that the cloned target gene product can be released from the GST moiety.

[0295] In an insect system, Autographa californica nuclear polyhedrosis virus (AcNPV) is used as a vector to express foreign genes. The virus grows in Spodoptera frugiperda cells. The antibody coding sequence may be cloned individually into non-essential regions (for example the polyhedrin gene) of the virus and placed under control of an AcNPV promoter (for example the polyhedrin promoter).

[0296] In mammalian host cells, a number of viral-based expression systems may be utilized. In cases where an adenovirus is used as an expression vector, the antibody coding sequence of interest may be ligated to an adenovirus transcription/translation control complex, e.g., the late promoter and tripartite leader sequence. This chimeric gene may then be inserted in the adenovirus genome by in vitro or in vivo recombination. Insertion in a non- essential region of the viral genome (e.g., region E1 or E3) will result in a recombinant virus that is viable and capable of expressing the antibody molecule in infected hosts. (e.g., see Logan & Shenk, Proc. Natl. Acad. Sci. USA 81:355-359 (1984)). Specific initiation signals may also be required for efficient translation of inserted antibody coding sequences. These signals include the ATG initiation codon and adjacent sequences. Furthermore, the initiation codon must be in phase with the reading frame of the desired coding sequence to ensure translation of the entire insert. These exogenous translational control signals and initiation codons can be of a variety of origins, both natural and synthetic. The efficiency of expression may be enhanced by the inclusion of appropriate transcription enhancer elements, transcription terminators, etc. (see Bittner et al., Methods in Enzymol. 153:51-544 (1987)).

[0297] In addition, a host cell strain may be chosen which modulates the expression of the inserted sequences, or modifies and processes the gene product in the specific fashion desired. Such modifications (e.g., glycosylation) and processing (e.g., cleavage) of protein products may be important for the function of the protein. Different host cells have characteristic and specific mechanisms for the post-translational processing and modification of proteins and gene products. Appropriate cell lines or host systems can be chosen to ensure the correct modification and processing of the foreign protein expressed. To this end, eukaryotic host cells which possess the cellular machinery for proper processing of the primary transcript, glycosylation, and phosphorylation of the gene product may be used. Such mammalian host cells include but are not limited to CHO, VERY, BHK, Hela, COS, MDCK, 293, 3T3, W138, and in particular, breast cancer cell lines such as, for example, BT483, Hs578T, HTB2, BT20 and T47D, and normal mammary gland cell line such as, for example, CRL7030 and Hs578Bst.

[0298] For long-term, high-yield production of recombinant proteins, stable expression is preferred. For example, cell lines which stably express the antibody molecule may be engineered. Rather than using expression vectors which contain viral origins of replication, host cells can be transformed with DNA controlled by appropriate expression control elements (e.g., promoter, enhancer, sequences, transcription terminators, polyadenylation sites, etc.), and a selectable marker. Following the introduction of the foreign DNA, engineered cells may be allowed to grow for 1-2 days in an enriched media, and then are switched to a selective media. The selectable marker in the recombinant plasmid confers resistance to the selection and allows cells to stably integrate the plasmid into their chromosomes and grow to form foci which in turn can be cloned and expanded into cell lines. This method may advantageously be used to engineer cell lines which express the antibody molecule. Such engineered cell lines may be particularly useful in screening and evaluation of compounds that interact directly or indirectly with the antibody molecule.

[0299] A number of selection systems may be used, including but not limited to the herpes simplex virus thymidine kinase (Wigler et al., Cell 11:223 (1977)), hypoxanthine-guanine phosphoribosyltransferase (Szybalska & Szybalski, Proc. Natl. Acad. Sci. USA 48:202 (1992)), and adenine phosphoribosyltransferase (Lowy et al., Cell 22:817 (1980)) genes can be employed in tk-, hgprt- or aprt- cells, respectively. Also, antimetabolite resistance can be used as the basis of selection for the following genes: dhfr, which confers resistance to methotrexate (Wigler et al., Natl. Acad. Sci. USA 77:357 (1980); O'Hare et al., Proc. Natl. Acad. Sci. USA 78:1527 (1981)); gpt, which confers resistance to mycophenolic acid (Mulligan & Berg, Proc. Natl. Acad. Sci. USA 78:2072 (1981)); neo, which confers resistance to the aminoglycoside G-418 Clinical Pharmacy 12:488-505; Wu and Wu, Biotherapy 3:87-95 (1991); Tolstoshev, Ann. Rev. Pharmacol. Toxicol. 32:573-596 (1993); Mulligan, Science 260:926-932 (1993); and Morgan and Anderson, Ann. Rev. Biochem. 62:191-217 (1993); TIB TECH 11(5):155-215 (1993)); and hygro, which confers resistance to hygromycin (Santerre et al., Gene 30:147 (1984)). Methods commonly known in the art of recombinant DNA technology may be routinely applied to select the desired recombinant clone, and such methods are described, for example, in Ausubel et al. (eds.), Current Protocols in Molecular Biology, John Wiley & Sons, NY (1993); Kriegler, Gene Transfer and Expression, A Laboratory Manual, Stockton Press, NY (1990); and in Chapters 12 and 13, Dracopoli et al. (eds), Current Protocols in Human Genetics, John Wiley & Sons, NY (1994); Colberre-Garapin et al., J. Mol. Biol. 150:1 (1981), which are incorporated by reference herein in their entireties.

[0300] The expression levels of an antibody molecule can be increased by vector amplification (for a review, see Bebbington and Hentschel, The use of vectors based on gene amplification for the expression of cloned genes in mammalian cells in DNA cloning, Vol.3. (Academic Press, New York, 1987)). When a marker in the vector system expressing antibody is amplifiable, increase in the level of inhibitor present in culture of host cell will increase the number of copies of the marker gene. Since the amplified region is associated with the antibody gene, production of the antibody will also increase (Crouse et al., Mol. Cell. Biol. 3:257 (1983)).

[0301] Vectors which use glutamine synthase (GS) or DHFR as the selectable markers can be amplified in the presence of the drugs methionine sulphoximine or methotrexate, respectively. An advantage of glutamine synthase based vectors are the availabilty of cell lines (e.g., the murine myeloma cell line, NSO) which are glutamine synthase negative. Glutamine synthase expression systems can also function in glutamine synthase expressing cells (e.g., Chinese Hamster Ovary (CHO) cells) by providing additional inhibitor to prevent the functioning of the endogenous gene. A glutamine synthase expression system and components thereof are detailed in PCT publications: WO87/04462; WO86/05807; WO89/01036; WO89/10404; and WO91/06657 which are incorporated in their entireties by reference herein. Additionally, glutamine synthase expression vectors that may be used according to the present invention are commercially available from suplliers, including, for example Lonza Biologics, Inc. (Portsmouth, N.H.). Expression and production of monoclonal antibodies using a GS expression system in murine myeloma cells is described in Bebbington et al., Bio/technology 10:169(1992) and in Biblia and Robinson Biotechnol. Prog. 11:1 (1995) which are incorporated in their entirities by reference herein.

[0302] The host cell may be co-transfected with two expression vectors of the invention, the first vector encoding a heavy chain derived polypeptide and the second vector encoding a light chain derived polypeptide. The two vectors may contain identical selectable markers which enable equal expression of heavy and light chain polypeptides. Alternatively, a single vector may be used which encodes, and is capable of expressing, both heavy and light chain polypeptides. In such situations, the light chain should be placed before the heavy chain to avoid an excess of toxic free heavy chain (Proudfoot, Nature 322:52 (1986); Kohler, Proc. Natl. Acad. Sci. USA 77:2197 (1980)). The coding sequences for the heavy and light chains may comprise cDNA or genomic DNA.

[0303] Once an antibody molecule of the invention has been produced by an animal, chemically synthesized, or recombinantly expressed, it may be purified by any method known in the art for purification of an immunoglobulin molecule, for example, by chromatography (e.g., ion exchange, affinity, particularly by affinity for the specific antigen after Protein A, and sizing column chromatography), centrifugation, differential solubility, or by any other standard technique for the purification of proteins. In addition, the antibodies of the present invention or fragments thereof can be fused to heterologous polypeptide sequences described herein or otherwise known in the art, to facilitate purification.

[0304] The present invention encompasses antibodies recombinantly fused or chemically conjugated (including both covalently and non-covalently conjugations) to a polypeptide (or portion thereof, preferably at least 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 amino acids of the polypeptide) of the present invention to generate fusion proteins. The fusion does not necessarily need to be direct, but may occur through linker sequences. The antibodies may be specific for antigens other than polypeptides (or portion thereof, preferably at least 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 amino acids of the polypeptide) of the present invention. For example, antibodies may be used to target the polypeptides of the present invention to particular cell types, either in vitro or in vivo, by fusing or conjugating the polypeptides of the present invention to antibodies specific for particular cell surface receptors. Antibodies fused or conjugated to the polypeptides of the present invention may also be used in in vitro immunoassays and purification methods using methods known in the art. See e.g., Harbor et al., supra, and PCT publication WO 93/21232; EP 439,095; Naramura et al., Immunol. Lett. 39:91-99 (1994); U.S. Pat. No. 5,474,981; Gillies et al., PNAS 89:1428-1432 (1992); Fell et al., J. Immunol. 146:2446-2452 (1991), which are incorporated by reference in their entireties.

[0305] The present invention further includes compositions comprising the polypeptides of the present invention fused or conjugated to antibody domains other than the variable regions. For example, the polypeptides of the present invention may be fused or conjugated to an antibody Fc region, or portion thereof. The antibody portion fused to a polypeptide of the present invention may comprise the constant region, hinge region, CH1 domain, CH2 domain, and CH3 domain or any combination of whole domains or portions thereof. The polypeptides may also be fused or conjugated to the above antibody portions to form multimers. For example, Fe portions fused to the polypeptides of the present invention can form dimers through disulfide bonding between the Fe portions. Higher multimeric forms can be made by fusing the polypeptides to portions of IgA and IgM. Methods for fusing or conjugating the polypeptides of the present invention to antibody portions are known in the art. See, e.g., U.S. Pat. Nos. 5,336,603; 5,622,929; 5,359,046; 5,349,053; 5,447,851; 5,112,946; EP 307,434; EP 367,166; PCT publications WO 96/04388; WO 91/06570; Ashkenazi et al., Proc. Natl. Acad. Sci. USA 88:10535-10539 (1991); Zheng et al., J. Immunol. 154:5590-5600 (1995); and Vil et al., Proc. Natl. Acad. Sci. USA 89:11337-11341 (1992) (said references incorporated by reference in their entireties).

[0306] As discussed, supra, the polypeptides corresponding to a polypeptide, polypeptide fragment, or a variant of SEQ ID NO: Y may be fused or conjugated to the above antibody portions to increase the in vivo half life of the polypeptides or for use in immunoassays using methods known in the art. Further, the polypeptides corresponding to SEQ ID NO: Y may be fused or conjugated to the above antibody portions to facilitate purification. One reported example describes chimeric proteins consisting of the first two domains of the human CD4-polypeptide and various domains of the constant regions of the heavy or light chains of mammalian immunoglobulins. See EP 394,827; Traunecker et al., Nature 331:84-86 (1988). The polypeptides of the present invention fused or conjugated to an antibody having disulfide-linked dimeric structures (due to the IgG) may also be more efficient in binding and neutralizing other molecules, than the monomeric secreted protein or protein fragment alone. See, for example, Fountoulakis et al., J. Biochem. 270:3958-3964 (1995). In many cases, the Fc part in a fusion protein is beneficial in therapy and diagnosis, and thus can result in, for example, improved pharmacokinetic properties. See, for example, EP A 232,262. Alternatively, deleting the Fc part after the fusion protein has been expressed, detected, and purified, would be desired. For example, the Fc portion may hinder therapy and diagnosis if the fusion protein is used as an antigen for immunizations. In drug discovery, for example, human proteins, such as hIL-5, have been fused with Fc portions for the purpose of high-throughput screening assays to identify antagonists of hIL-5. (See, Bennett et al., J. Molecular Recognition 8:52-58 (1995); Johanson et al., J. Biol. Chem. 270:9459-9471 (1995)).

[0307] Moreover, the antibodies or fragments thereof of the present invention can be fused to marker sequences, such as a peptide to facilitate purification. In preferred embodiments, the marker amino acid sequence is a hexa-histidine peptide, such as the tag provided in a pQE vector (QIAGEN, Inc., 9259 Eton Avenue, Chatsworth, Calif., 91311), among others, many of which are commercially available. As described in Gentz et al., Proc. Natl. Acad. Sci. USA 86:821-824 (1989), for instance, hexa-histidine provides for convenient purification of the fusion protein. Other peptide tags useful for purification include, but are not limited to, the “HA” tag, which corresponds to an epitope derived from the influenza hemagglutinin protein (Wilson et al., Cell 37:767 (1984)) and the “flag” tag.

[0308] The present invention further encompasses antibodies or fragments thereof conjugated to a diagnostic or therapeutic agent. The antibodies can be used diagnostically to, for example, monitor the development or progression of a tumor as part of a clinical testing procedure to, e.g., determine the efficacy of a given treatment regimen. Detection can be facilitated by coupling the antibody to a detectable substance. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, radioactive materials, positron emitting metals using various positron emission tomographies, and nonradioactive paramagnetic metal ions. The detectable substance may be coupled or conjugated either directly to the antibody (or fragment thereof) or indirectly, through an intermediate (such as, for example, a linker known in the art) using techniques known in the art. See, for example, U.S. Pat. No. 4,741,900 for metal ions which can be conjugated to antibodies for use as diagnostics according to the present invention.

[0309] Further, an antibody or fragment thereof may be conjugated to a therapeutic moiety such as a cytotoxin, e.g., a cytostatic or cytocidal agent, a therapeutic agent or a radioactive metal ion, e.g., alpha-emitters such as, for example, 213Bi. A cytotoxin or cytotoxic agent includes any agent that is detrimental to cells. Examples include paclitaxol, cytochalasin B, gramicidin D, ethidium bromide, emetine, mitomycin, etoposide, tenoposide, vincristine, vinblastine, colchicin, doxorubicin, daunorubicin, dihydroxy anthracin dione, mitoxantrone, mithramycin, actinomycin D, 1-dehydrotestosterone, glucocorticoids, procaine, tetracaine, lidocaine, propranolol, and puromycin and analogs or homologs thereof. Therapeutic agents include, but are not limited to, antimetabolites (e.g., methotrexate, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-fluorouracil decarbazine), alkylating agents (e.g., mechlorethamine, thioepa chlorambucil, melphalan, carmustine (BSNU) and lomustine (CCNU), cyclothosphamide, busulfan, dibromomannitol, streptozotocin, mitomycin C, and cis- dichlorodiamine platinum (II) (DDP) cisplatin), anthracyclines (e.g., daunorubicin (formerly daunomycin) and doxorubicin), antibiotics (e.g., dactinomycin (formerly actinomycin), bleomycin, mithramycin, and anthramycin (AMC)), and anti-mitotic agents (e.g., vincristine and vinblastine).

[0310] The conjugates of the invention can be used for modifying a given biological response, the therapeutic agent or drug moiety is not to be construed as limited to classical chemical therapeutic agents. For example, the drug moiety may be a protein or polypeptide possessing a desired biological activity. Such proteins may include, for example, a toxin such as abrin, ricin A, pseudomonas exotoxin, or diphtheria toxin; a protein such as tumor necrosis factor, α-interferon, δ-interferon, nerve growth factor, platelet derived growth factor, tissue plasminogen activator, an apoptotic agent, e.g., TNF-alpha, TNF-beta, AIM I (See, International Publication No. WO 97/33899), AIM II (See, International Publication No. WO 97/34911), Fas Ligand (Takahashi et al., Int. Immunol., 6:1567-1574 (1994)), VEGI (See, International Publication No. WO 99/23105), a thrombotic agent or an anti- angiogenic agent, e.g., angiostatin or endostatin; or, biological response modifiers such as, for example, lymphokines, interleukin-1 (“IL-1”), interleukin-2 (“IL-2”), interleukin-6 (“IL-6”), granulocyte macrophage colony stimulating factor (“GM-CSF”), granulocyte colony stimulating factor (“G-CSF”), or other growth factors.

[0311] Antibodies may also be attached to solid supports, which are particularly useful for immunoassays or purification of the target antigen. Such solid supports include, but are not limited to, glass, cellulose, polyacrylamide, nylon, polystyrene, polyvinyl chloride or polypropylene.

[0312] Techniques for conjugating such therapeutic moiety to antibodies are well known. See, for example., Arnon et al., “Monoclonal Antibodies For Immunotargeting Of Drugs In Cancer Therapy”, in Monoclonal Antibodies And Cancer Therapy, Reisfeld et al. (eds.), pp. 243-56 (Alan R. Liss, Inc. 1985); Hellstrom et al., “Antibodies For Drug Delivery”, in Controlled Drug Delivery (2nd Ed.), Robinson et al. (eds.), pp. 623-53 (Marcel Dekker, Inc. 1987); Thorpe, “Antibody Carriers Of Cytotoxic Agents In Cancer Therapy: A Review”, in Monoclonal Antibodies '84: Biological And Clinical Applications, Pinchera et al. (eds.), pp. 475-506 (1985); “Analysis, Results, And Future Prospective Of The Therapeutic Use Of Radiolabeled Antibody In Cancer Therapy”, in Monoclonal Antibodies For Cancer Detection And Therapy, Baldwin et al. (eds.), pp. 303-16 (Academic Press 1985), and Thorpe et al., “The Preparation And Cytotoxic Properties Of Antibody-Toxin Conjugates”, Immunol. Rev. 62:119-58 (1982).

[0313] Alternatively, an antibody can be conjugated to a second antibody to form an antibody heteroconjugate as described by Segal in U.S. Pat. No. 4,676,980, which is incorporated herein by reference in its entirety.

[0314] An antibody, with or without a therapeutic moiety conjugated to it, administered alone or in combination with cytotoxic factor(s) and/or cytokine(s) can be used as a therapeutic.

[0315] Immunophenotyping

[0316] The antibodies of the invention may be utilized for immunophenotyping of cell lines and biological samples. Translation products of the genes of the present invention may be useful as cell specific markers, or more specifically as cellular markers that are differentially expressed at various stages of differentiation and/or maturation of particular cell types. Monoclonal antibodies directed against a specific epitope, or combination of epitopes, will allow for the screening of cellular populations expressing the marker. Various techniques can be utilized using monoclonal antibodies to screen for cellular populations expressing the marker(s), and include magnetic separation using antibody-coated magnetic beads, “panning” with antibody attached to a solid matrix (i.e., plate), and flow cytometry (See, e.g., U.S. Pat. No. 5,985,660; and Morrison et al., Cell, 96:737-49 (1999)).

[0317] These techniques allow for the screening of particular populations of cells, such as might be found with hematological malignancies (i.e. minimal residual disease (MRD) in acute leukemic patients) and “non-self” cells in transplantations to prevent Graft-versus-Host Disease (GVHD). Alternatively, these techniques allow for the screening of hematopoietic stem and progenitor cells capable of undergoing proliferation and/or differentiation, as might be found in human umbilical cord blood.

[0318] Assays For Antibody Binding

[0319] The antibodies of the invention may be assayed for immunospecific binding by any method known in the art. The immunoassays which can be used include but are not limited to competitive and non-competitive assay systems using techniques such as western blots, radioimmunoassays, ELISA (enzyme linked immunosorbent assay), “sandwich” immunoassays, immunoprecipitation assays, precipitin reactions, gel diffusion precipitin reactions, immunodiffusion assays, agglutination assays, complement-fixation assays, immunoradiometric assays, fluorescent immunoassays, and protein A immunoassays, to name but a few. Such assays are routine and well known in the art (see, e.g., Ausubel et al, eds, 1994, Current Protocols in Molecular Biology, Vol. 1, John Wiley & Sons, Inc., New York, which is incorporated by reference herein in its entirety). Exemplary immunoassays are described briefly below (but are not intended by way of limitation).

[0320] Immunoprecipitation protocols generally comprise lysing a population of cells in a lysis buffer such as RIPA buffer (1% NP-40 or Triton X-100, 1% sodium deoxycholate, 0.1% SDS, 0.15 M NaCl, 0.01 M sodium phosphate at pH 7.2, 1% Trasylol) supplemented with protein phosphatase and/or protease inhibitors (e.g., EDTA, PMSF, aprotinin, sodium vanadate), adding the antibody of interest to the cell lysate, incubating for a period of time (e.g., 1-4 hours) at 4° C., adding protein A and/or protein G sepharose beads to the cell lysate, incubating for about an hour or more at 4° C., washing the beads in lysis buffer and resuspending the beads in SDS/sample buffer. The ability of the antibody of interest to immunoprecipitate a particular antigen can be assessed by, e.g., western blot analysis. One of skill in the art would be knowledgeable as to the parameters that can be modified to increase the binding of the antibody to an antigen and decrease the background (e.g., pre-clearing the cell lysate with sepharose beads). For further discussion regarding immunoprecipitation protocols see, e.g., Ausubel et al., eds., (1994), Current Protocols in Molecular Biology, Vol. 1, John Wiley & Sons, Inc., New York, section 10.16.1.

[0321] Western blot analysis generally comprises preparing protein samples, electrophoresis of the protein samples in a polyacrylamide gel (e.g., 8%-20% SDS-PAGE depending on the molecular weight of the antigen), transferring the protein sample from the polyacrylamide gel to a membrane such as nitrocellulose, PVDF or nylon, blocking the membrane in blocking solution (e.g., PBS with 3% BSA or non-fat milk), washing the membrane in washing buffer (e.g., PBS-Tween 20), blocking the membrane with primary antibody (the antibody of interest) diluted in blocking buffer, washing the membrane in washing buffer, blocking the membrane with a secondary antibody (which recognizes the primary antibody, e.g., an anti-human antibody) conjugated to an enzymatic substrate (e.g., horseradish peroxidase or alkaline phosphatase) or radioactive molecule (e.g., 32P or 125I) diluted in blocking buffer, washing the membrane in wash buffer, and detecting the presence of the antigen. One of skill in the art would be knowledgeable as to the parameters that can be modified to increase the signal detected and to reduce the background noise. For further discussion regarding western blot protocols see, e.g., Ausubel et al., eds., (1994), Current Protocols in Molecular Biology, Vol. 1, John Wiley & Sons, Inc., New York, section 10.8.1.

[0322] ELISAs comprise preparing antigen, coating the well of a 96 well microtiter plate with the antigen, adding the antibody of interest conjugated to a detectable compound such as an enzymatic substrate (e.g., horseradish peroxidase or alkaline phosphatase) to the well and incubating for a period of time, and detecting the presence of the antigen. In ELISAs the antibody of interest does not have to be conjugated to a detectable compound; instead, a second antibody (which recognizes the antibody of interest) conjugated to a detectable compound may be added to the well. Further, instead of coating the well with the antigen, the antibody may be coated to the well. In this case, a second antibody conjugated to a detectable compound may be added following the addition of the antigen of interest to the coated well. One of skill in the art would be knowledgeable as to the parameters that can be modified to increase the signal detected as well as other variations of ELISAs known in the art. For further discussion regarding ELISAs see, e.g., Ausubel et al., eds., (1994), Current Protocols in Molecular Biology, Vol. 1, John Wiley & Sons, Inc., New York, section 11.2.1.

[0323] The binding affinity of an antibody to an antigen and the off-rate of an antibody-antigen interaction can be determined by competitive binding assays. One example of a competitive binding assay is a radioimmunoassay comprising the incubation of labeled antigen (e.g., 3H or 125I) with the antibody of interest in the presence of increasing amounts of unlabeled antigen, and the detection of the antibody bound to the labeled antigen. The affinity of the antibody of interest for a particular antigen and the binding off-rates can be determined from the data by scatchard plot analysis. Competition with a second antibody can also be determined using radioimmunoassays. In this case, the antigen is incubated with antibody of interest conjugated to a labeled compound (e.g., 3H or 125I) in the presence of increasing amounts of an unlabeled second antibody.

[0324] Antibodies of the invention may be characterized using immunocytochemisty methods on cells (e.g., mammalian cells, such as CHO cells) transfected with a vector enabling the expression of a reproductive system antigen or with vector alone using techniques commonly known in the art. Antibodies that bind reproductive system antigen transfected cells, but not vector-only transfected cells, are reproductive system antigen specific.

[0325] Therapeutic Uses

[0326] The present invention is further directed to antibody-based therapies which involve administering antibodies of the invention to an animal, preferably a mammal, and most preferably a human, patient for treating one or more of the disclosed diseases, disorders, or conditions. Therapeutic compounds of the invention include, but are not limited to, antibodies of the invention (including fragments, analogs and derivatives thereof as described herein) and nucleic acids encoding antibodies of the invention (including fragments, analogs and derivatives thereof and anti-idiotypic antibodies as described herein). The antibodies of the invention can be used to treat, inhibit or prevent diseases, disorders or conditions associated with aberrant expression and/or activity of a polypeptide of the invention, including, but not limited to, any one or more of the diseases, disorders, or conditions described herein. The treatment and/or prevention of diseases, disorders, or conditions associated with aberrant expression and/or activity of a polypeptide of the invention includes, but is not limited to, alleviating symptoms associated with those diseases, disorders or conditions. Antibodies of the invention may be provided in pharmaceutically acceptable compositions as known in the art or as described herein.

[0327] In a specific and preferred embodiment, the present invention is directed to antibody-based therapies which involve administering antibodies of the invention to an animal, preferably a mammal, and most preferably a human, patient for treating one or more of the diseases, disorders, or conditions of the reproductive system, including, but not limited to, injuries and trauma, infections, neoplastic disorders, congenital defects, and diseases or disorders which result in infertility, complications with pregnancy, labor, or parturition, postpartum difficulties,and as listed below in the section entitled “Reproductive System Disorders”. Therapeutic compounds of the invention include, but are not limited to, antibodies of the invention (e.g., antibodies directed to the full length protein expressed on the cell surface of a mammalian cell; antibodies directed to an epitope of a reproductive system associated polypeptide of the invention (such as, a linear epitope (shown in Table 1A, column 6) or a conformational epitope), including fragments, analogs and derivatives thereof as described herein) and nucleic acids encoding antibodies of the invention (including fragments, analogs and derivatives thereof and anti-idiotypic antibodies as described herein). The antibodies of the invention can be used to treat, inhibit or prevent diseases, disorders or conditions associated with aberrant expression and/or activity of a polypeptide of the invention, including, but not limited to, any one or more of the diseases, disorders, or conditions of the reproductive system described herein. The treatment and/or prevention of diseases, disorders, or conditions of the reproductive system associated with aberrant expression and/or activity of a polypeptide of the invention includes, but is not limited to, alleviating symptoms associated with those diseases, disorders or conditions. Antibodies of the invention may be provided in pharmaceutically acceptable compositions as known in the art or as described herein.

[0328] A summary of the ways in which the antibodies of the present invention may be used therapeutically includes binding polynucleotides or polypeptides of the present invention locally or systemically in the body or by direct cytotoxicity of the antibody, e.g. as mediated by complement (CDC) or by effector cells (ADCC). Some of these approaches are described in more detail below. Armed with the teachings provided herein, one of ordinary skill in the art will know how to use the antibodies of the present invention for diagnostic, monitoring or therapeutic purposes without undue experimentation.

[0329] The antibodies of this invention may be advantageously utilized in combination with other monoclonal or chimeric antibodies, or with lymphokines or hematopoietic growth factors (such as, e.g., IL-2, IL-3 and IL-7), for example, which serve to increase the number or activity of effector cells which interact with the antibodies.

[0330] The antibodies of the invention may be administered alone or in combination with other types of treatments (e.g., radiation therapy, chemotherapy, hormonal therapy, immunotherapy and anti-tumor agents). Generally, administration of products of a species origin or species reactivity (in the case of antibodies) that is the same species as that of the patient is preferred. Thus, in a preferred embodiment, human antibodies, fragments derivatives, analogs, or nucleic acids, are administered to a human patient for therapy or prophylaxis.

[0331] It is preferred to use high affinity and/or potent in vivo inhibiting and/or neutralizing antibodies against polypeptides or polynucleotides of the present invention, fragments or regions thereof, for both immunoassays directed to and therapy of disorders related to polynucleotides or polypeptides, including fragments thereof, of the present invention. Such antibodies, fragments, or regions, will preferably have an affinity for polynucleotides or polypeptides of the invention, including fragments thereof. Preferred binding affinities include those with a dissociation constant or Kd less than 5×10⁻² M, 10⁻² M, 5×10⁻³ M, 10⁻³ M, 5×10⁻⁴ M, 10⁻⁴ M, 5×10⁻⁵ M, 10⁻⁵ M, 5×10⁻⁶ M, 10⁻⁶ M, 5×10⁻⁷ M, 10⁻⁷ M, 5×10⁻⁸ M, 10⁻⁸ M, 5×10⁻⁹ M, 10⁻⁹ M, 5×10⁻¹⁰ M, 10⁻¹⁰ M, 5×10⁻¹¹ M, 10⁻¹¹ M, 5×10⁻¹² M, 10¹² ⁻M, 5×10⁻¹³ M, 10⁻¹³ M, 5×10⁻¹⁴ M, 10⁻¹⁴ M, 5×10⁻¹⁵ M, and 10⁻¹⁵ M.

[0332] Gene Therapy

[0333] In a specific embodiment, nucleic acids comprising sequences encoding antibodies or functional derivatives thereof, are administered to treat, inhibit or prevent a disease or disorder associated with aberrant expression and/or activity of a polypeptide of the invention, by way of gene therapy. Gene therapy refers to therapy performed by the administration to a subject of an expressed or expressible nucleic acid. In this embodiment of the invention, the nucleic acids produce their encoded protein that mediates a therapeutic effect.

[0334] Any of the methods for gene therapy available in the art can be used according to the present invention. Exemplary methods are described below.

[0335] For general reviews of the methods of gene therapy, see Goldspiel et al., Clinical Pharmacy 12:488-505 (1993); Wu and Wu, Biotherapy 3:87-95 (1991); Tolstoshev, Ann. Rev. Pharmacol. Toxicol. 32:573-596 (1993); Mulligan, Science 260:926-932 (1993); and Morgan and Anderson, Ann. Rev. Biochem. 62:191-217 (1993); May, TIBTECH 11(5):155-215 (1993). Methods commonly known in the art of recombinant DNA technology which can be used are described in Ausubel et al. (eds.), Current Protocols in Molecular Biology, John Wiley & Sons, NY (1993); and Kriegler, Gene Transfer and Expression, A Laboratory Manual, Stockton Press, NY (1990).

[0336] In a preferred embodiment, the compound comprises nucleic acid sequences encoding an antibody, said nucleic acid sequences being part of expression vectors that express the antibody or fragments or chimeric proteins or heavy or light chains thereof in a suitable host. In particular, such nucleic acid sequences have promoters operably linked to the antibody coding region, said promoter being inducible or constitutive, and, optionally, tissue-specific. In another particular embodiment, nucleic acid molecules are used in which the antibody coding sequences and any other desired sequences are flanked by regions that promote homologous recombination at a desired site in the genome, thus providing for intrachromosomal expression of the antibody encoding nucleic acids (Koller and Smithies, Proc. Natl. Acad. Sci. USA 86:8932-8935 (1989); Zijlstra et al., Nature 342:435-438 (1989). In specific embodiments, the expressed antibody molecule is a single chain antibody; alternatively, the nucleic acid sequences include sequences encoding both the heavy and light chains, or fragments thereof, of the antibody.

[0337] Delivery of the nucleic acids into a patient may be either direct, in which case the patient is directly exposed to the nucleic acid or nucleic acid- carrying vectors, or indirect, in which case, cells are first transformed with the nucleic acids in vitro, then transplanted into the patient. These two approaches are known, respectively, as in vivo or ex vivo gene therapy.

[0338] In a specific embodiment, the nucleic acid sequences are directly administered in vivo, where it is expressed to produce the encoded product. This can be accomplished by any of numerous methods known in the art, e.g., by constructing them as part of an appropriate nucleic acid expression vector and administering it so that they become intracellular, e.g., by infection using defective or attenuated retrovirals or other viral vectors (see U.S. Pat. No. 4,980,286), or by direct injection of naked DNA, or by use of microparticle bombardment (e.g., a gene gun; Biolistic, Dupont), or coating with lipids or cell-surface receptors or transfecting agents, encapsulation in liposomes, microparticles, or microcapsules, or by administering them in linkage to a peptide which is known to enter the nucleus, by administering it in linkage to a ligand subject to receptor-mediated endocytosis (see, e.g., Wu and Wu, J. Biol. Chem. 262:4429-4432 (1987)) (which can be used to target cell types specifically expressing the receptors), etc. In another embodiment, nucleic acid-ligand complexes can be formed in which the ligand comprises a fusogenic viral peptide to disrupt endosomes, allowing the nucleic acid to avoid lysosomal degradation. In yet another embodiment, the nucleic acid can be targeted in vivo for cell specific uptake and expression, by targeting a specific receptor (see, e.g., PCT Publications WO 92/06180; WO 92/22635; WO92/20316; WO93/14188, WO 93/20221). Alternatively, the nucleic acid can be introduced intracellularly and incorporated within host cell DNA for expression, by homologous recombination (Koller and Smithies, Proc. Natl. Acad. Sci. USA 86:8932-8935 (1989); Zijlstra et al., Nature 342:435-438 (1989)).

[0339] In a specific embodiment, viral vectors that contains nucleic acid sequences encoding an antibody of the invention are used. For example, a retroviral vector can be used (see Miller et al., Meth. Enzymol. 217:581-599 (1993)). These retroviral vectors contain the components necessary for the correct packaging of the viral genome and integration into the host cell DNA. The nucleic acid sequences encoding the antibody to be used in gene therapy are cloned into one or more vectors, which facilitates delivery of the gene into a patient. More detail about retroviral vectors can be found in Boesen et al., Biotherapy 6:291-302 (1994), which describes the use of a retroviral vector to deliver the mdrl gene to hematopoietic stem cells in order to make the stem cells more resistant to chemotherapy. Other references illustrating the use of retroviral vectors in gene therapy are: Clowes et al., J. Clin. Invest. 93:644-651 (1994); Kiem et al., Blood 83:1467-1473 (1994); Salmons and Gunzberg, Human Gene Therapy 4:129-141 (1993); and Grossman and Wilson, Curr. Opin. in Genetics and Devel. 3:110-114 (1993).

[0340] Adenoviruses are other viral vectors that can be used in gene therapy. Adenoviruses are especially attractive vehicles for delivering genes to respiratory epithelia. Adenoviruses naturally infect respiratory epithelia where they cause a mild disease. Other targets for adenovirus-based delivery systems are liver, the central nervous system, endothelial cells, and muscle. Adenoviruses have the advantage of being capable of infecting non-dividing cells. Kozarsky and Wilson, Current Opinion in Genetics and Development 3:499-503 (1993) present a review of adenovirus-based gene therapy. Bout et al., Human Gene Therapy 5:3-10 (1994) demonstrated the use of adenovirus vectors to transfer genes to the respiratory epithelia of rhesus monkeys. Other instances of the use of adenoviruses in gene therapy can be found in Rosenfeld et al., Science 252:431-434 (1991); Rosenfeld et al., Cell 68:143-155 (1992); Mastrangeli et al., J. Clin. Invest. 91:225-234 (1993); PCT Publication WO94/12649; and Wang, et al., Gene Therapy 2:775-783 (1995). In a preferred embodiment, adenovirus vectors are used.

[0341] Adeno-associated virus (AAV) has also been proposed for use in gene therapy (Walsh et al., Proc. Soc. Exp. Biol. Med. 204:289-300 (1993); U.S. Patent No. 5,436,146).

[0342] Another approach to gene therapy involves transferring a gene to cells in tissue culture by such methods as electroporation, lipofection, calcium phosphate mediated transfection, or viral infection. Usually, the method of transfer includes the transfer of a selectable marker to the cells. The cells are then placed under selection to isolate those cells that have taken up and are expressing the transferred gene. Those cells are then delivered to a patient.

[0343] In this embodiment, the nucleic acid is introduced into a cell prior to administration in vivo of the resulting recombinant cell. Such introduction can be carried out by any method known in the art, including but not limited to transfection, electroporation, microinjection, infection with a viral or bacteriophage vector containing the nucleic acid sequences, cell fusion, chromosome-mediated gene transfer, microcell-mediated gene transfer, spheroplast fusion, etc. Numerous techniques are known in the art for the introduction of foreign genes into cells (see, e.g., Loeffler and Behr, Meth. Enzymol. 217:599-618 (1993); Cohen et al., Meth. Enzymol. 217:618-644 (1993); Cline, Pharmac. Ther. 29:69-92m (1985) and may be used in accordance with the present invention, provided that the necessary developmental and physiological functions of the recipient cells are not disrupted. The technique should provide for the stable transfer of the nucleic acid to the cell, so that the nucleic acid is expressible by the cell and preferably heritable and expressible by its cell progeny.

[0344] The resulting recombinant cells can be delivered to a patient by various methods known in the art. Recombinant blood cells (e.g., hematopoietic stem or progenitor cells) are preferably administered intravenously. The amount of cells envisioned for use depends on the desired effect, patient state, etc., and can be determined by one skilled in the art.

[0345] Cells into which a nucleic acid can be introduced for purposes of gene therapy encompass any desired, available cell type, and include but are not limited to epithelial cells, endothelial cells, keratinocytes, fibroblasts, muscle cells, hepatocytes; blood cells such as T lymphocytes, B lymphocytes, monocytes, macrophages, neutrophils, eosinophils, megakaryocytes, granulocytes; various stem or progenitor cells, in particular hematopoietic stem or progenitor cells, e.g., as obtained from bone marrow, umbilical cord blood, peripheral blood, fetal liver, etc.

[0346] In a preferred embodiment, the cell used for gene therapy is autologous to the patient.

[0347] In an embodiment in which recombinant cells are used in gene therapy, nucleic acid sequences encoding an antibody are introduced into the cells such that they are expressible by the cells or their progeny, and the recombinant cells are then administered in vivo for therapeutic effect. In a specific embodiment, stem or progenitor cells are used. Any stem and/or progenitor cells which can be isolated and maintained in vitro can potentially be used in accordance with this embodiment of the present invention (see e.g. PCT Publication WO 94/08598; Stemple and Anderson, Cell 71:973-985 (1992); Rheinwald, Meth. Cell Bio. 21A:229 (1980); and Pittelkow and Scott, Mayo Clinic Proc. 61:771 (1986)).

[0348] In a specific embodiment, the nucleic acid to be introduced for purposes of gene therapy comprises an inducible promoter operably linked to the coding region, such that expression of the nucleic acid is controllable by the presence or absence of an appropriate inducer of transcription.

[0349] Demonstration of Therapeutic or Prophylactic Activity

[0350] The compounds or pharmaceutical compositions of the invention are preferably tested in vitro, and then in vivo for the desired therapeutic or prophylactic activity, prior to use in humans. For example, in vitro assays to demonstrate the therapeutic or prophylactic utility of a compound or pharmaceutical composition include, the effect of a compound on a cell line or a patient tissue sample. The effect of the compound or composition on the cell line and/or tissue sample can be determined utilizing techniques known to those of skill in the art including, but not limited to, rosette formation assays and cell lysis assays. In accordance with the invention, in vitro assays which can be used to determine whether administration of a specific compound is indicated, include in vitro cell culture assays in which a patient tissue sample is grown in culture, and exposed to or otherwise administered a compound, and the effect of such compound upon the tissue sample is observed.

[0351] Therapeutic/Prophylactic Administration and Composition

[0352] The invention provides methods of treatment, inhibition and prophylaxis by administration to a subject of an effective amount of a compound or pharmaceutical composition of the invention, preferably a polypeptide or antibody of the invention. In a preferred embodiment, the compound is substantially purified (e.g., substantially free from substances that limit its effect or produce undesired side-effects). The subject is preferably an animal, including but not limited to animals such as cows, pigs, horses, chickens, cats, dogs, etc., and is preferably a mammal, and most preferably human.

[0353] Formulations and methods of administration that can be employed when the compound comprises a nucleic acid or an immunoglobulin are described above; additional appropriate formulations and routes of administration can be selected from among those described herein below.

[0354] Various delivery systems are known and can be used to administer a compound of the invention, e.g., encapsulation in liposomes, microparticles, microcapsules, recombinant cells capable of expressing the compound, receptor-mediated endocytosis (see, e.g., Wu and Wu, J. Biol. Chem. 262:4429-4432 (1987)), construction of a nucleic acid as part of a retroviral or other vector, etc. Methods of introduction include but are not limited to intradermal, intramuscular, intraperitoneal, intravenous, subcutaneous, intranasal, epidural, and oral routes. The compounds or compositions may be administered by any convenient route, for example by infusion or bolus injection, by absorption through epithelial or mucocutaneous linings (e.g., oral mucosa, rectal and intestinal mucosa, etc.) and may be administered together with other biologically active agents. Administration can be systemic or local. In addition, it may be desirable to introduce the pharmaceutical compounds or compositions of the invention into the central nervous system by any suitable route, including intraventricular and intrathecal injection; intraventricular injection may be facilitated by an intraventricular catheter, for example, attached to a reservoir, such as an Ommaya reservoir. Pulmonary administration can also be employed, e.g., by use of an inhaler or nebulizer, and formulation with an aerosolizing agent.

[0355] In a specific embodiment, it may be desirable to administer the pharmaceutical compounds or compositions of the invention locally to the area in need of treatment; this may be achieved by, for example, and not by way of limitation, local infusion during surgery, topical application, e.g., in conjunction with a wound dressing after surgery, by injection, by means of a catheter, by means of a suppository, or by means of an implant, said implant being of a porous, non-porous, or gelatinous material, including membranes, such as sialastic membranes, or fibers. Preferably, when administering a protein, including an antibody, of the invention, care must be taken to use materials to which the protein does not absorb.

[0356] In another embodiment, the compound or composition can be delivered in a vesicle, in particular a liposome (see Langer, Science 249:1527-1533 (1990); Treat et al., in Liposomes in the Therapy of Infectious Disease and Cancer, Lopez-Berestein and Fidler (eds.), Liss, New York, pp. 353-365 (1989); Lopez-Berestein, ibid., pp. 317-327; see generally ibid.)

[0357] In yet another embodiment, the compound or composition can be delivered in a controlled release system. In one embodiment, a pump may be used (see Langer, supra; Sefton, CRC Crit. Ref. Biomed. Eng. 14:201 (1987); Buchwald et al., Surgery 88:507 (1980); Saudek et al., N. Engl. J. Med. 321:574 (1989)). In another embodiment, polymeric materials can be used (see Medical Applications of Controlled Release, Langer and Wise (eds.), CRC Pres., Boca Raton, Florida (1974); Controlled Drug Bioavailability, Drug Product Design and Performance, Smolen and Ball (eds.), Wiley, New York (1984); Ranger and Peppas, J., Macromol. Sci. Rev. Macromol. Chem. 23:61 (1983); see also Levy et al., Science 228:190 (1985); During et al., Ann. Neurol. 25:351 (1989); Howard et al., J.Neurosurg. 71:105 (1989)). In yet another embodiment, a controlled release system can be placed in proximity of the therapeutic target, e.g., the brain, thus requiring only a fraction of the systemic dose (see, e.g., Goodson, in Medical Applications of Controlled Release, supra, vol. 2, pp. 115-138 (1984)).

[0358] Other controlled release systems are discussed in the review by Langer (Science 249:1527-1533 (1990)).

[0359] In a specific embodiment where the compound of the invention is a nucleic acid encoding a protein, the nucleic acid can be administered in vivo to promote expression of its encoded protein, by constructing it as part of an appropriate nucleic acid expression vector and administering it so that it becomes intracellular, e.g., by use of a retroviral vector (see U.S. Pat. No. 4,980,286), or by direct injection, or by use of microparticle bombardment (e.g., a gene gun; Biolistic, Dupont), or coating with lipids or cell-surface receptors or transfecting agents, or by administering it in linkage to a homeobox- like peptide which is known to enter the nucleus (see e.g., Joliot et al., Proc. Natl. Acad. Sci. USA 88:1864-1868 (1991)), etc. Alternatively, a nucleic acid can be introduced intracellularly and incorporated within host cell DNA for expression, by homologous recombination.

[0360] The present invention also provides pharmaceutical compositions. Such compositions comprise a therapeutically effective amount of a compound, and a pharmaceutically acceptable carrier. In a specific embodiment, the term “pharmaceutically acceptable” means approved by a regulatory agency of the Federal or a state government or listed in the U.S. Pharmacopeia or other generally recognized pharmacopeia for use in animals, and more particularly in humans. The term “carrier” refers to a diluent, adjuvant, excipient, or vehicle with which the therapeutic is administered. Such pharmaceutical carriers can be sterile liquids, such as water and oils, including those of petroleum, animal, vegetable or synthetic origin, such as peanut oil, soybean oil, mineral oil, sesame oil and the like. Water is a preferred carrier when the pharmaceutical composition is administered intravenously. Saline solutions and aqueous dextrose and glycerol solutions can also be employed as liquid carriers, particularly for injectable solutions. Suitable pharmaceutical excipients include starch, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, sodium stearate, glycerol monostearate, talc, sodium chloride, dried skim milk, glycerol, propylene, glycol, water, ethanol and the like. The composition, if desired, can also contain minor amounts of wetting or emulsifying agents, or pH buffering agents. These compositions can take the form of solutions, suspensions, emulsion, tablets, pills, capsules, powders, sustained-release formulations and the like. The composition can be formulated as a suppository, with traditional binders and carriers such as triglycerides. Oral formulation can include standard carriers such as pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, sodium saccharine, cellulose, magnesium carbonate, etc. Examples of suitable pharmaceutical carriers are described in “Remington's Pharmaceutical Sciences” by E. W. Martin. Such compositions will contain a therapeutically effective amount of the compound, preferably in purified form, together with a suitable amount of carrier so as to provide the form for proper administration to the patient. The formulation should suit the mode of administration.

[0361] In a preferred embodiment, the composition is formulated in accordance with routine procedures as a pharmaceutical composition adapted for intravenous administration to human beings. Typically, compositions for intravenous administration are solutions in sterile isotonic aqueous buffer. Where necessary, the composition may also include a solubilizing agent and a local anesthetic such as lignocaine to ease pain at the site of the injection. Generally, the ingredients are supplied either separately or mixed together in unit dosage form, for example, as a dry lyophilized powder or water free concentrate in a hermetically sealed container such as an ampoule or sachette indicating the quantity of active agent. Where the composition is to be administered by infusion, it can be dispensed with an infusion bottle containing sterile pharmaceutical grade water or saline. Where the composition is administered by injection, an ampoule of sterile water for injection or saline can be provided so that the ingredients may be mixed prior to administration.

[0362] The compounds of the invention can be formulated as neutral or salt forms. Pharmaceutically acceptable salts include those formed with anions such as those derived from hydrochloric, phosphoric, acetic, oxalic, tartaric acids, etc., and those formed with cations such as those derived from sodium, potassium, ammonium, calcium, ferric hydroxides, isopropylamine, triethylamine, 2-ethylamino ethanol, histidine, procaine, etc.

[0363] The amount of the compound of the invention which will be effective in the treatment, inhibition and prevention of a disease or disorder associated with aberrant expression and/or activity of a polypeptide of the invention can be determined by standard clinical techniques. In addition, in vitro assays may optionally be employed to help identify optimal dosage ranges. The precise dose to be employed in the formulation will also depend on the route of administration, and the seriousness of the disease or disorder, and should be decided according to the judgment of the practitioner and each patient's circumstances. Effective doses may be extrapolated from dose-response curves derived from in vitro or animal model test systems.

[0364] For antibodies, the dosage administered to a patient is typically 0.1 mg/kg to 100 mg/kg of the patient's body weight. Preferably, the dosage administered to a patient is between 0.1 mg/kg and 20 mg/kg of the patient's body weight, more preferably 1 mg/kg to 10 mg/kg of the patient's body weight. Generally, human antibodies have a longer half-life within the human body than antibodies from other species due to the immune response to the foreign polypeptides. Thus, lower dosages of human antibodies and less frequent administration is often possible. Further, the dosage and frequency of administration of antibodies of the invention may be reduced by enhancing uptake and tissue penetration (e.g., into the brain) of the antibodies by modifications such as, for example, lipidation.

[0365] The invention also provides a pharmaceutical pack or kit comprising one or more containers filled with one or more of the ingredients of the pharmaceutical compositions of the invention. Optionally associated with such container(s) can be a notice in the form prescribed by a governmental agency regulating the manufacture, use or sale of pharmaceuticals or biological products, which notice reflects approval by the agency of manufacture, use or sale for human administration.

[0366] Diagnosis and Imaging

[0367] Labeled antibodies, and derivatives and analogs thereof, which specifically bind to a polypeptide of interest can be used for diagnostic purposes to detect, diagnose, or monitor diseases, disorders, and/or conditions associated with the aberrant expression and/or activity of a polypeptide of the invention. The invention provides for the detection of aberrant expression of a polypeptide of interest, comprising (a) assaying the expression of the polypeptide of interest in cells or body fluid of an individual using one or more antibodies specific to the polypeptide interest and (b) comparing the level of gene expression with a standard gene expression level, whereby an increase or decrease in the assayed polypeptide gene expression level compared to the standard expression level is indicative of aberrant expression.

[0368] The invention provides a diagnostic assay for diagnosing a reproductive system disorder, comprising (a) assaying the expression of the polypeptide of interest in cells or body fluid of an individual using one or more antibodies specific to the polypeptide interest and (b) comparing the level of gene expression with a standard gene expression level, whereby an increase or decrease in the assayed polypeptide gene expression level compared to the standard expression level is indicative of a particular disorder. With respect to cancer, the presence of a relatively high amount of transcript in biopsied tissue from an individual may indicate a predisposition for the development of the disease, or may provide a means for detecting the disease prior to the appearance of actual clinical symptoms. A more definitive diagnosis of this type may allow health professionals to employ preventative measures or aggressive treatment earlier thereby preventing the development or further progression of the cancer.

[0369] Antibodies of the invention can be used to assay protein levels in a biological sample using classical immunohistological methods known to those of skill in the art (e.g., see Jalkanen et al., J. Cell. Biol. 101:976-985 (1985); Jalkanen et al., J. Cell. Biol. 105:3087-3096 (1987)). Other antibody-based methods useful for detecting protein gene expression include immunoassays, such as the enzyme linked immunosorbent assay (ELISA) and the radioimmunoassay (RIA). Suitable antibody assay labels are known in the art and include enzyme labels, such as, glucose oxidase; radioisotopes, such as iodine (125I, 121I), carbon (14C), sulfur (35S), tritium (3H), indium (112In), and technetium (99Tc); luminescent labels, such as luminol; and fluorescent labels, such as fluorescein and rhodamine, and biotin.

[0370] One facet of the invention is the detection and diagnosis of a disease or disorder associated with aberrant expression of a polypeptide of interest in an animal, preferably a mammal and most preferably a human. A preferred embodiment of the invention is the detection and diagnosis of a disease or disorder of the reproductive system associated with aberrant expression of a reproductive system antigen in an animal, preferably a mammal and most preferably a human. In one embodiment, diagnosis comprises: a) administering (for example, parenterally, subcutaneously, or intraperitoneally) to a subject an effective amount of a labeled molecule which specifically binds to the polypeptide of interest; b) waiting for a time interval following the administering for permitting the labeled molecule to preferentially concentrate at sites in the subject where the polypeptide is expressed (and for unbound labeled molecule to be cleared to background level); c) determining background level; and d) detecting the labeled molecule in the subject, such that detection of labeled molecule above the background level indicates that the subject has a particular disease or disorder associated with aberrant expression of the polypeptide of interest. Background level can be determined by various methods including, comparing the amount of labeled molecule detected to a standard value previously determined for a particular system.

[0371] It will be understood in the art that the size of the subject and the imaging system used will determine the quantity of imaging moiety needed to produce diagnostic images. In the case of a radioisotope moiety, for a human subject, the quantity of radioactivity injected will normally range from about 5 to 20 millicuries of 99mTc. The labeled antibody or antibody fragment will then preferentially accumulate at the location of cells which contain the specific protein. In vivo tumor imaging is described in S. W. Burchiel et al., “Immunopharmacokinetics of Radiolabeled Antibodies and Their Fragments.” (Chapter 13 in Tumor Imaging: The Radiochemical Detection of Cancer, S. W. Burchiel and B. A. Rhodes, eds., Masson Publishing Inc. (1982)).

[0372] Depending on several variables, including the type of label used and the mode of administration, the time interval following the administration for permitting the labeled molecule to preferentially concentrate at sites in the subject and for unbound labeled molecule to be cleared to background level is 6 to 48 hours or 6 to 24 hours or 6 to 12 hours. In another embodiment the time interval following administration is 5 to 20 days or 5 to 10 days.

[0373] In an embodiment, monitoring of the disease or disorder is carried out by repeating the method for diagnosing the disease or disorder, for example, one month after initial diagnosis, six months after initial diagnosis, one year after initial diagnosis, etc.

[0374] Presence of the labeled molecule can be detected in the patient using methods known in the art for in vivo scanning. These methods depend upon the type of label used. Skilled artisans will be able to determine the appropriate method for detecting a particular label. Methods and devices that may be used in the diagnostic methods of the invention include, but are not limited to, computed tomography (CT), whole body scan such as position emission tomography (PET), magnetic resonance imaging (MRI), and sonography.

[0375] In a specific embodiment, the molecule is labeled with a radioisotope and is detected in the patient using a radiation responsive surgical instrument (Thurston et al., U.S. Pat. No. 5,441,050). In another embodiment, the molecule is labeled with a fluorescent compound and is detected in the patient using a fluorescence responsive scanning instrument. In another embodiment, the molecule is labeled with a positron emitting metal and is detected in the patent using positron emission-tomography. In yet another embodiment, the molecule is labeled with a paramagnetic label and is detected in a patient using magnetic resonance imaging (MRI).

[0376] Kits

[0377] The present invention provides kits that can be used in the above methods. In one embodiment, a kit comprises an antibody of the invention, preferably a purified antibody, in one or more containers. In a specific embodiment, the kits of the present invention contain a substantially isolated polypeptide comprising an epitope which is specifically immunoreactive with an antibody included in the kit. Preferably, the kits of the present invention further comprise a control antibody which does not react with the polypeptide of interest. In another specific embodiment, the kits of the present invention contain a means for detecting the binding of an antibody to a polypeptide of interest (e.g., the antibody may be conjugated to a detectable substrate such as a fluorescent compound, an enzymatic substrate, a radioactive compound or a luminescent compound, or a second antibody which recognizes the first antibody may be conjugated to a detectable substrate).

[0378] In another specific embodiment of the present invention, the kit is a diagnostic kit for use in screening serum containing antibodies specific against proliferative and/or cancerous polynucleotides and polypeptides. Such a kit may include a control antibody that does not react with the polypeptide of interest. Such a kit may include a substantially isolated polypeptide antigen comprising an epitope which is specifically immunoreactive with at least one anti-polypeptide antigen antibody. Further, such a kit includes means for detecting the binding of said antibody to the antigen (e.g., the antibody may be conjugated to a fluorescent compound such as fluorescein or rhodamine which can be detected by flow cytometry). In specific embodiments, the kit may include a recombinantly produced or chemically synthesized polypeptide antigen. The polypeptide antigen of the kit may also be attached to a solid support.

[0379] In a more specific embodiment the detecting means of the above-described kit includes a solid support to which said polypeptide antigen is attached. Such a kit may also include a non-attached reporter-labeled anti-human antibody. In this embodiment, binding of the antibody to the polypeptide antigen can be detected by binding of the said reporter-labeled antibody.

[0380] In an additional embodiment, the invention includes a diagnostic kit for use in screening serum containing antigens of the polypeptide of the invention. The diagnostic kit includes a substantially isolated antibody specifically immunoreactive with polypeptide or polynucleotide antigens, and means for detecting the binding of the polynucleotide or polypeptide antigen to the antibody. In one embodiment, the antibody is attached to a solid support. In a specific embodiment, the antibody may be a monoclonal antibody. The detecting means of the kit may include a second, labeled monoclonal antibody. Alternatively, or in addition, the detecting means may include a labeled, competing antigen.

[0381] In one diagnostic configuration, test serum is reacted with a solid phase reagent having a surface-bound antigen obtained by the methods of the present invention. After binding with specific antigen antibody to the reagent and removing unbound serum components by washing, the reagent is reacted with reporter-labeled anti-human antibody to bind reporter to the reagent in proportion to the amount of bound anti-antigen antibody on the solid support. The reagent is again washed to remove unbound labeled antibody, and the amount of reporter associated with the reagent is determined. Typically, the reporter is an enzyme which is detected by incubating the solid phase in the presence of a suitable fluorometric, luminescent or colorimetric substrate (Sigma, St. Louis, Mo.).

[0382] The solid surface reagent in the above assay is prepared by known techniques for attaching protein material to solid support material, such as polymeric beads, dip sticks, 96-well plate or filter material. These attachment methods generally include non-specific adsorption of the protein to the support or covalent attachment of the protein, typically through a free amine group, to a chemically reactive group on the solid support, such as an activated carboxyl, hydroxyl, or aldehyde group. Alternatively, streptavidin coated plates can be used in conjunction with biotinylated antigen(s).

[0383] Thus, the invention provides an assay system or kit for carrying out this diagnostic method. The kit generally includes a support with surface-bound recombinant antigens, and a reporter-labeled anti-human antibody for detecting surface-bound anti-antigen antibody.

[0384] Uses of the Polynucleotides

[0385] Each of the polynucleotides identified herein can be used in numerous ways as reagents. The following description should be considered exemplary and utilizes known techniques.

[0386] The polynucleotides of the present invention are useful for chromosome identification. There exists an ongoing need to identify new chromosome markers, since few chromosome marking reagents, based on actual sequence data (repeat polymorphisms), are presently available. Each sequence is specifically targeted to and can hybridize with a particular location on an individual human chromosome, thus each polynucleotide of the present invention can routinely be used as a chromosome marker using techniques known in the art. Table 1A, column 8 provides the chromosome location of some of the polynucleotides of the invention.

[0387] Briefly, sequences can be mapped to chromosomes by preparing PCR primers (preferably at least 15 bp (e.g., 15-25 bp) from the sequences shown in SEQ ID NO: X. Primers can optionally be selected using computer analysis so that primers do not span more than one predicted exon in the genomic DNA. These primers are then used for PCR screening of somatic cell hybrids containing individual human chromosomes. Only those hybrids containing the human gene corresponding to SEQ ID NO: X will yield an amplified fragment.

[0388] Similarly, somatic hybrids provide a rapid method of PCR mapping the polynucleotides to particular chromosomes. Three or more clones can be assigned per day using a single thermal cycler. Moreover, sublocalization of the polynucleotides can be achieved with panels of specific chromosome fragments. Other gene mapping strategies that can be used include in situ hybridization, prescreening with labeled flow-sorted chromosomes, preselection by hybridization to construct chromosome specific-cDNA libraries, and computer mapping techniques (See, e.g., Shuler, Trends Biotechnol 16:456-459 (1998) which is hereby incorporated by reference in its entirety).

[0389] Precise chromosomal location of the polynucleotides can also be achieved using fluorescence in situ hybridization (FISH) of a metaphase chromosomal spread. This technique uses polynucleotides as short as 500 or 600 bases; however, polynucleotides 2,000-4,000 bp are preferred. For a review of this technique, see Verma et al., “Human Chromosomes: a Manual of Basic Techniques,” Pergamon Press, New York (1988).

[0390] For chromosome mapping, the polynucleotides can be used individually (to mark a single chromosome or a single site on that chromosome) or in panels (for marking multiple sites and/or multiple chromosomes)

[0391] Thus, the present invention also provides a method for chromosomal localization which involves (a) preparing PCR primers from the polynucleotide sequences in Table 1A and/or Table 2 and SEQ ID NO: X and (b) screening somatic cell hybrids containing individual chromosomes.

[0392] The polynucleotides of the present invention would likewise be useful for radiation hybrid mapping, HAPPY mapping, and long range restriction mapping. For a review of these techniques and others known in the art, see, e.g. Dear, “Genome Mapping: A Practical Approach,” IRL Press at Oxford University Press, London (1997); Aydin, J. Mol. Med. 77:691-694 (1999); Hacia et al., Mol. Psychiatry 3:483-492 (1998); Herrick et al., Chromosome Res. 7:409-423 (1999); Hamilton et al., Methods Cell Biol. 62:265-280 (2000); and/or Ott, J. Hered. 90:68-70 (1999), each of which is hereby incorporated by reference in its entirety.

[0393] Once a polynucleotide has been mapped to a precise chromosomal location, the physical position of the polynucleotide can be used in linkage analysis. Linkage analysis establishes coinheritance between a chromosomal location and presentation of a particular disease. (Disease mapping data are found, for example, in V. McKusick, Mendelian Inheritance in Man (available on line through Johns Hopkins University Welch Medical Library).) Column 9 of Table 1A provides an OMIM reference identification number of diseases associated with the cytologic band disclosed in column 8 of Table 1A, as determined using techniques described herein and by reference to Table 5. Assuming I megabase mapping resolution and one gene per 20 kb, a cDNA precisely localized to a chromosomal region associated with the disease could be one of 50-500 potential causative genes.

[0394] Thus, once coinheritance is established, differences in a polynucleotide of the invention and the corresponding gene between affected and unaffected individuals can be examined. First, visible structural alterations in the chromosomes, such as deletions or translocations, are examined in chromosome spreads or by PCR. If no structural alterations exist, the presence of point mutations are ascertained. Mutations observed in some or all affected individuals, but not in normal individuals, indicates that mutations may cause the disease. However, complete sequencing of the polypeptide and the corresponding gene from several normal individuals is required to distinguish the mutation from a polymorphism. If a new polymorphism is identified, this polymorphic polypeptide can be used for further linkage analysis.

[0395] Furthermore, increased or decreased expression of the gene in affected individuals as compared to unaffected individuals can be assessed using the polynucleotides of the invention. Any of these alterations (altered expression, chromosomal rearrangement, or mutation) can be used as a diagnostic or prognostic marker. Diagnostic and prognostic methods, kits and reagents encompassed by the present invention are briefly described below and more thoroughly elsewhere herein (see e.g., the sections labeled “Antibodies”, “Diagnostic Assays”, and “Methods for Detecting Reproductive System Disease, Including Cancer”).

[0396] Thus, the invention also provides a diagnostic method useful during diagnosis of a disorder, involving measuring the expression level of polynucleotides of the present invention in cells or body fluid from an individual and comparing the measured gene expression level with a standard level of polynucleotide expression level, whereby an increase or decrease in the gene expression level compared to the standard is indicative of a disorder. Additional non-limiting examples of diagnostic methods encompassed by the present invention are more thoroughly described elsewhere herein (see, e.g., Example 12).

[0397] In still another embodiment, the invention includes a kit for analyzing samples for the presence of proliferative and/or cancerous polynucleotides derived from a test subject, as further described herein. In a general embodiment, the kit includes at least one polynucleotide probe containing a nucleotide sequence that will specifically hybridize with a polynucleotide of the invention and a suitable container. In a specific embodiment, the kit includes two polynucleotide probes defining an internal region of the polynucleotide of the invention, where each probe has one strand containing a 31′mer-end internal to the region. In a further embodiment, the probes may be useful as primers for polymerase chain reaction amplification.

[0398] Where a diagnosis of a related disorder, including, for example, diagnosis of a tumor, has already been made according to conventional methods, the present invention is useful as a prognostic indicator, whereby patients exhibiting enhanced or depressed polynucleotide of the invention expression will experience a worse clinical outcome relative to patients expressing the gene at a level nearer the standard level.

[0399] By “measuring the expression level of polynucleotides of the invention” is intended qualitatively or quantitatively measuring or estimating the level of the polypeptide of the invention or the level of the mRNA encoding the polypeptide of the invention in a first biological sample either directly (e.g., by determining or estimating absolute protein level or mRNA level) or relatively (e.g., by comparing to the polypeptide level or mRNA level in a second biological sample). Preferably, the polypeptide level or mRNA level in the first biological sample is measured or estimated and compared to a standard polypeptide level or mRNA level, the standard being taken from a second biological sample obtained from an individual not having the related disorder or being determined by averaging levels from a population of individuals not having a related disorder. As will be appreciated in the art, once a standard polypeptide level or mRNA level is known, it can be used repeatedly as a standard for comparison.

[0400] By “biological sample” is intended any biological sample obtained from an individual, body fluid, cell line, tissue culture, or other source which contains polypeptide of the present invention or the corresponding mRNA. As indicated, biological samples include body fluids (such as semen, lymph, vaginal pool, sera, plasma, urine, synovial fluid and spinal fluid) which contain the polypeptide of the present invention, and tissue sources found to express the polypeptide of the present invention. Methods for obtaining tissue biopsies and body fluids from mammals are well known in the art. Where the biological sample is to include mRNA, a tissue biopsy is the preferred source.

[0401] The method(s) provided above may preferably be applied in a diagnostic method and/or kits in which polynucleotides and/or polypeptides of the invention are attached to a solid support. In one exemplary method, the support may be a “gene chip” or a “biological chip” as described in U.S. Pat. Nos. 5,837,832, 5,874,219, and 5,856,174. Further, such a gene chip with polynucleotides of the invention attached may be used to identify polymorphisms between the isolated polynucleotide sequences of the invention, with polynucleotides isolated from a test subject. The knowledge of such polymorphisms (i.e., their location, as well as, their existence) would be beneficial in identifying disease loci for many disorders, such as for example, in neural disorders, immune system disorders, muscular disorders, reproductive disorders, gastrointestinal disorders, pulmonary disorders, digestive disorders, cardiovascular disorders, renal disorders, proliferative disorders, and/or cancerous diseases and conditions. Such a method is described in U.S. Pat. No. 5,858,659 and 5,856,104. The U.S. Patents referenced supra are hereby incorporated by reference in their entirety herein.

[0402] The present invention encompasses polynucleotides of the present invention that are chemically synthesized, or reproduced as peptide nucleic acids (PNA), or according to other methods known in the art. The use of PNAs would serve as the preferred form if the polynucleotides of the invention are incorporated onto a solid support, or gene chip. For the purposes of the present invention, a peptide nucleic acid (PNA) is a polyamide type of DNA analog and the monomeric units for adenine, guanine, thymine and cytosine are available commercially (Perceptive Biosystems). Certain components of DNA, such as phosphorus, phosphorus oxides, or deoxyribose derivatives, are not present in PNAs. As disclosed by Nielsen et al., Science 254:1497 (1991); and Egholm et al., Nature 365:666 (1993), PNAs bind specifically and tightly to complementary DNA strands and are not degraded by nucleases. In fact, PNA binds more strongly to DNA than DNA itself does. This is probably because there is no electrostatic repulsion between the two strands, and also the polyamide backbone is more flexible. Because of this, PNA/DNA duplexes bind under a wider range of stringency conditions than DNA/DNA duplexes, making it easier to perform multiplex hybridization. Smaller probes can be used than with DNA due to the strong binding. In addition, it is more likely that single base mismatches can be determined with PNA/DNA hybridization because a single mismatch in a PNA/DNA 15-mer lowers the melting point (T.sub.m) by 8°-20° C., vs. 4°-16° C. for the DNA/DNA 15-mer duplex. Also, the absence of charge groups in PNA means that hybridization can be done at low ionic strengths and reduce possible interference by salt during the analysis.

[0403] The compounds of the present invention have uses which include, but are not limited to, detecting cancer in mammals. In particular the invention is useful during diagnosis of pathological cell proliferative neoplasias which include, but are not limited to: acute myelogenous leukemias including acute monocytic leukemia, acute myeloblastic leukemia, acute promyelocytic leukemia, acute myelomonocytic leukemia, acute erythroleukemia, acute megakaryocytic leukemia, and acute undifferentiated leukemia, etc.; and chronic myelogenous leukemias including chronic myelomonocytic leukemia, chronic granulocytic leukemia, etc. Preferred mammals include monkeys, apes, cats, dogs, cows, pigs, horses, rabbits and humans. Particularly preferred are humans.

[0404] The compounds of the present invention have preferred uses which include, but are not limited to, detecting reproductive system cancers in mammals. In particular the invention is useful during diagnosis of pathological cell proliferative neoplasias which include, but are not limited to: testicular cancers (including, for example, teratocarcinoma, embryonal cell carcinoma, yolk sac tumors, Leydig cell tumors, and as listed below in the section entitiled “Reproductive System Disorders”), prostate cancers (e.g., adenocarcinomas, transitional cell carcinomas, ductal carcinomas, squamous cell carcinomas, and as listed below in the section entitled “Reproductive System Disorders”), penile cancers (such as squamous cell carcinoma, verrucous carcinoma, penile urethral carcinoma, and as listed below in the section entitled “Reproductive System Disorders”), cancers of the vagina and vulva (including, for example, basal cell carcinoma, melanomas, cancer of Bartholin's gland, and as listed below in the section entitled “Reproductive System Disorders”), uterine cancers (such as adenocarcinomas, keiomyosarcomas, and as listed below in the section entitled “Reproductive System Disorders”), ovarian cancers (e.g., Sertoli-Leydig tumors, endometriod carcinoma of the ovary, ovarian papollary serous adenocarcinoma, ovarian Krukenberg tumors, and as listed below in the section entitled “Reproductive System Disorders”), and cancers of the cervix (including, for example, squamous metaplasia, columnar cell neoplasia, squamous cell carcinoma, and as listed below in the section entitled “Reproductive System Disorders”). Preferred mammals include monkeys, apes, cats, dogs, cows, pigs, horses, rabbits and humans. Particularly preferred are humans.

[0405] Pathological cell proliferative disorders are often associated with inappropriate activation of proto-oncogenes. (Gelmann, E. P. et al., “The Etiology of Acute Leukemia: Molecular Genetics and Viral Oncology,” in Neoplastic Diseases of the Blood, Vol 1., Wiemik, P. H. et al. eds., 161-182 (1985)). Neoplasias are now believed to result from the qualitative alteration of a normal cellular gene product, or from the quantitative modification of gene expression by insertion into the chromosome of a viral sequence, by chromosomal translocation of a gene to a more actively transcribed region, or by some other mechanism. (Gelmann et al., supra) It is likely that mutated or altered expression of specific genes is involved in the pathogenesis of some leukemias, among other tissues and cell types. (Gelmann et al., supra) Indeed, the human counterparts of the oncogenes involved in some animal neoplasias have been amplified or translocated in some cases of human leukemia and carcinoma. (Gelmann et al., supra)

[0406] For example, c-myc expression is highly amplified in the non-lymphocytic leukemia cell line HL-60. When HL-60 cells are chemically induced to stop proliferation, the level of c-myc is found to be downregulated. (International Publication Number WO 91/15580). However, it has been shown that exposure of HL-60 cells to a DNA construct that is complementary to the 5′ end of c-myc or c-myb blocks translation of the corresponding mRNAs which downregulates expression of the c-myc or c-myb proteins and causes arrest of cell proliferation and differentiation of the treated cells. (International Publication Number WO 91/15580; Wickstrom et al., Proc. Natl. Acad. Sci. 85:1028 (1988); Anfossi et al., Proc. Natl. Acad. Sci. 86:3379 (1989)). However, the skilled artisan would appreciate the present invention's usefulness is not be limited to treatment, prevention, diagnosis and/or prognosis, of proliferative disorders of cells and tissues of hematopoietic origin, in light of the numerous cells and cell types of varying origins which are known to exhibit proliferative phenotypes. In preferred embodiments, the compounds and/or methods of the invention are used to treat, prevent, diagnose, and/or prognose, proliferative disorders of reproductive system cells and tissues.

[0407] In addition to the foregoing, a polynucleotide of the present invention can be used to control gene expression through triple helix formation or through antisense DNA or RNA. Antisense techniques are discussed, for example, in Okano, J. Neurochem. 56: 560 (1991); “Oligodeoxynucleotides as Antisense Inhibitors of Gene Expression, CRC Press, Boca Raton, Fla. (1988). Triple helix formation is discussed in, for instance Lee et al., Nucleic Acids Research 6: 3073 (1979); Cooney et al., Science 241: 456 (1988); and Dervan et al., Science 251: 1360 (1991). Both methods rely on binding of the polynucleotide to a complementary DNA or RNA. For these techniques, preferred polynucleotides are usually oligonucleotides 20 to 40 bases in length and complementary to either the region of the gene involved in transcription (triple helix—see Lee et al., Nucl. Acids Res. 6:3073 (1979); Cooney et al., Science 241:456 (1988); and Dervan et al., Science 251:1360 (1991)) or to the mRNA itself (antisense—Okano, J. Neurochem. 56:560 (1991); Oligodeoxy-nucleotides as Antisense Inhibitors of Gene Expression, CRC Press, Boca Raton, Fla. (1988).) Triple helix formation optimally results in a shut-off of RNA transcription from DNA, while antisense RNA hybridization blocks translation of an mRNA molecule into polypeptide. The oligonucleotide described above can also be delivered to cells such that the antisense RNA or DNA may be expressed in vivo to inhibit production of polypeptide of the present invention antigens. Both techniques are effective in model systems, and the information disclosed herein can be used to design antisense or triple helix polynucleotides in an effort to treat disease, and in particular, for the treatment of proliferative diseases and/or conditions. Non-limiting antisense and triple helix methods encompassed by the present invention are more thoroughly described elsewhere herein (see, e.g., the section labeled “Antisense and Ribozyme (Antagonists)”).

[0408] Polynucleotides of the present invention are also useful in gene therapy. One goal of gene therapy is to insert a normal gene into an organism having a defective gene, in an effort to correct the genetic defect. The polynucleotides disclosed in the present invention offer a means of targeting such genetic defects in a highly accurate manner. Another goal is to insert a new gene that was not present in the host genome, thereby producing a new trait in the host cell. Additional non-limiting examples of gene therapy methods encompassed by the present invention are more thoroughly described elsewhere herein (see, e.g., the sections labeled “Gene Therapy Methods” and Examples 16, 17 and 18).

[0409] The polynucleotides are also useful for identifying individuals from minute biological samples. The United States military, for example, is considering the use of restriction fragment length polymorphism (RFLP) for identification of its personnel. In this technique, an individual's genomic DNA is digested with one or more restriction enzymes, and probed on a Southern blot to yield unique bands for identifying personnel. This method does not suffer from the current limitations of “Dog Tags” which can be lost, switched, or stolen, making positive identification difficult. The polynucleotides of the present invention can be used as additional DNA markers for RFLP.

[0410] The polynucleotides of the present invention can also be used as an alternative to RFLP, by determining the actual base-by-base DNA sequence of selected portions of an individual's genome. These sequences can be used to prepare PCR primers for amplifying and isolating such selected DNA, which can then be sequenced. Using this technique, individuals can be identified because each individual will have a unique set of DNA sequences. Once an unique ID database is established for an individual, positive identification of that individual, living or dead, can be made from extremely small tissue samples.

[0411] Forensic biology also benefits from using DNA-based identification techniques as disclosed herein. DNA sequences taken from very small biological samples such as tissues, e.g., hair or skin, or body fluids, e.g., blood, saliva, semen, synovial fluid, amniotic fluid, breast milk, lymph, pulmonary sputum or surfactant, urine, fecal matter, etc., can be amplified using PCR. In one prior art technique, gene sequences amplified from polymorphic loci, such as DQa class II HLA gene, are used in forensic biology to identify individuals. (Erlich, H., PCR Technology, Freeman and Co. (1992).) Once these specific polymorphic loci are amplified, they are digested with one or more restriction enzymes, yielding an identifying set of bands on a Southern blot probed with DNA corresponding to the DQa class II HLA gene. Similarly, polynucleotides of the present invention can be used as polymorphic markers for forensic purposes.

[0412] There is also a need for reagents capable of identifying the source of a particular tissue. Such need arises, for example, in forensics when presented with tissue of unknown origin. Appropriate reagents can comprise, for example, DNA probes or primers prepared from the sequences of the present invention, specific to tissues, including but not limited to, those sequences referred to in Table 1A. Panels of such reagents, can identify tissue by species and/or by organ type. In a similar fashion, these reagents can be used to screen tissue cultures for contamination. Additional non-limiting examples of such uses are further described herein.

[0413] Because reproductive system antigens are found expressed in reproductive system tissues, the polynucleotides of the present invention are also useful as hybridization probes for differential identification of the tissue(s) or cell type(s) present in a biological sample. Similarly, polypeptides and antibodies directed to polypeptides of the present invention are useful to provide immunological probes for differential identification of the tissue(s) (e.g., immunohistochemistry assays) or cell type(s) (e.g., immunocytochemistry assays). In a specific embodiment, the polynucleotides of the present invention are also useful as hybridization probes for differential identification of reproductive system tissue(s) or cell type(s) present in a biological sample. Similarly, polypeptides and antibodies directed to polypeptides of the present invention are useful to provide immunological probes for differential identification of reproductive system tissue(s) (e.g., immunohistochemistry assays) or cell type(s) (e.g., immunocytochemistry assays). In addition, for a number of disorders of the above tissues or cells, significantly higher or lower levels of gene expression of the polynucleotides/polypeptides of the present invention may be detected in certain tissues (e.g., tissues expressing polypeptides and/or polynucleotides of the present invention, for example, normal reproductive system tissues or diseased reproductive system tissues, and/or those tissues/cells corresponding to the library source relating to a polynucleotide sequence of the invention as disclosed in column 7 of Table 1A, and/or cancerous and/or wounded tissues) or bodily fluids (e.g., semen, lymph, vaginal pool, serum, plasma, urine, synovial fluid or spinal fluid) taken from an individual having such a disorder, relative to a “standard” gene expression level, i.e., the expression level in healthy tissue from an individual not having the disorder.

[0414] Thus, the invention provides a diagnostic method of a disorder, which involves: (a) assaying gene expression level in cells or body fluid of an individual; (b) comparing the gene expression level with a standard gene expression level, whereby an increase or decrease in the assayed gene expression level compared to the standard expression level is indicative of a disorder.

[0415] In the very least, the polynucleotides of the present invention can be used as molecular weight markers on Southern gels, as diagnostic probes for the presence of a specific mRNA in a particular cell type, as a probe to “subtract-out” known sequences in the process of discovering novel polynucleotides, for selecting and making oligomers for attachment to a “gene chip” or other support, to raise anti-DNA antibodies using DNA immunization techniques, and as an antigen to elicit an immune response.

[0416] Uses of the Polypeptides

[0417] Each of the polypeptides identified herein can be used in numerous ways. The following description should be considered exemplary and utilizes known techniques.

[0418] Polypeptides and antibodies directed to polypeptides of the present invention are useful to provide immunological probes for differential identification of the tissue(s) (e.g., immunohistochemistry assays such as, for example, ABC immunoperoxidase (Hsu et al., J. Histochem. Cytochem. 29:577-580 (1981)) or cell type(s) (e.g., immunocytochemistry assays).

[0419] Antibodies can be used to assay levels of polypeptides encoded by polynucleotides of the invention in a biological sample using classical immunohistological methods known to those of skill in the art (see, e.g., Jalkanen, et al., J. Cell. Biol. 101:976-985 (1985); Jalkanen, et al., J. Cell. Biol. 105:3087-3096 (1987)). Other antibody-based methods useful for detecting protein gene expression include immunoassays, such as the enzyme linked immunosorbent assay (ELISA) and the radioimmunoassay (RIA). Suitable antibody assay labels are known in the art and include enzyme labels, such as, glucose oxidase; radioisotopes, such as iodine (¹³¹I, ¹²⁵I, ¹²³I, ¹²¹I), carbon (¹⁴C), sulfur (³⁵S), tritium (³H), indium (^(115m)In, ^(113m)In, ¹¹²In, ¹¹¹In), and technetium (⁹⁹Tc, ^(99m)Tc), thallium (²⁰¹Ti), gallium (⁶⁸Ga, ⁶⁷Ga), palladium (¹⁰³Pd), molybdenum (⁹⁹Mo), xenon (¹³³Xe), fluorine (¹⁸F), ¹⁵³Sm, ¹⁷⁷Lu, ¹⁵⁹Gd, ¹⁴⁹Pm, ¹⁴⁰La, ¹⁷⁵Yb, ¹⁶⁶Ho, ⁹⁰Y, ⁴⁷Sc, ¹⁸⁶Re, ¹⁸⁸Re, ¹⁴²Pr, ¹⁰⁵Rh, ⁹⁷Ru; luminescent labels, such as luminol; and fluorescent labels, such as fluorescein and rhodamine, and biotin.

[0420] In addition to assaying levels of polypeptide of the present invention in a biological sample, proteins can also be detected in vivo by imaging. Antibody labels or markers for in vivo imaging of protein include those detectable by X-radiography, NMR or ESR. For X-radiography, suitable labels include radioisotopes such as barium or cesium, which emit detectable radiation but are not overtly harmful to the subject. Suitable markers for NMR and ESR include those with a detectable characteristic spin, such as deuterium, which may be incorporated into the antibody by labeling of nutrients for the relevant hybridoma.

[0421] A reproductive system antigen-specific antibody or antibody fragment which has been labeled with an appropriate detectable imaging moiety, such as a radioisotope (for example, ¹³¹I, ¹¹²In, ^(99m)Tc, (¹³¹I, ¹²⁵I, ¹²³I, ¹²¹I), carbon (¹⁴C), sulfur (³⁵S), tritium (³H), indium (^(115m)In, ^(113m)In, ¹¹²In, ¹¹¹I), and technetium (⁹⁹Tc, ^(99m)Tc), thallium (²⁰¹Ti), gallium (⁶⁸Ga, ⁶⁷Ga), palladium (¹⁰³Pd), molybdenum (⁹⁹Mo), xenon (¹³³Xe), fluorine (¹⁸F, ¹⁵³Sm, ¹⁷⁷Lu, ¹⁵⁹Gd, ¹⁴⁹Pm, ¹⁴⁰La, ¹⁷⁵Yb, ¹⁶⁶Ho, ⁹⁰Y, ⁴⁷Sc, ¹⁸⁶Re, ¹⁸⁸Re, ¹⁴²Pr, ¹⁰⁵Rh, ⁹⁷Ru), a radio-opaque substance, or a material detectable by nuclear magnetic resonance, is introduced (for example, parenterally, subcutaneously or intraperitoneally) into the mammal to be examined for reproductive system disorder. It will be understood in the art that the size of the subject and the imaging system used will determine the quantity of imaging moiety needed to produce diagnostic images. In the case of a radioisotope moiety, for a human subject, the quantity of radioactivity injected will normally range from about 5 to 20 millicuries of ^(99m)Tc. The labeled antibody or antibody fragment will then preferentially accumulate at the location of cells which express the polypeptide encoded by a polynucleotide of the invention. In vivo tumor imaging is described in S. W. Burchiel et al., “Immunopharmacokinetics of Radiolabeled Antibodies and Their Fragments” (Chapter 13 in Tumor Imaging: The Radiochemical Detection of Cancer, S. W. Burchiel and B. A. Rhodes, eds., Masson Publishing Inc. (1982)).

[0422] In one embodiment, the invention provides a method for the specific delivery of compositions of the invention to cells by administering polypeptides of the invention (e.g., polypeptides encoded by polynucleotides of the invention and/or antibodies) that are associated with heterologous polypeptides or nucleic acids. In one example, the invention provides a method for delivering a therapeutic protein into the targeted cell. In another example, the invention provides a method for delivering a single stranded nucleic acid (e.g., antisense or ribozymes) or double stranded nucleic acid (e.g., DNA that can integrate into the cell's genome or replicate episomally and that can be transcribed) into the targeted cell.

[0423] In another embodiment, the invention provides a method for the specific destruction of cells (e.g., the destruction of tumor cells) by administering polypeptides of the invention in association with toxins or cytotoxic prodrugs.

[0424] In a preferred embodiment, the invention provides a method for the specific destruction of reproductive system cells (e.g., aberrant reproductive system cells, neoplasms of the reproductive system) by administering polypeptides of the invention (e.g., polypeptides encoded by polynucleotides of the invention and/or antibodies) in association with toxins or cytotoxic prodrugs. In another preferred embodiment the invention provides a method for the specific destruction of tissues/cells corresponding to the library source relating to a polynucleotide sequence of the invention as disclosed in column 7 of Table 1A by administering polypeptides of the invention in association with toxins or cytotoxic prodrugs.

[0425] By “toxin” is meant one or more compounds that bind and activate endogenous cytotoxic effector systems, radioisotopes, holotoxins, modified toxins, catalytic subunits of toxins, or any molecules or enzymes not normally present in or on the surface of a cell that under defined conditions cause the cell's death. Toxins that may be used according to the methods of the invention include, but are not limited to, radioisotopes known in the art, compounds such as, for example, antibodies (or complement fixing containing portions thereof) that bind an inherent or induced endogenous cytotoxic effector system, thymidine kinase, endonuclease, RNAse, alpha toxin, ricin, abrin, Pseudomonas exotoxin A, diphtheria toxin, saporin, momordin, gelonin, pokeweed antiviral protein, alpha-sarcin and cholera toxin. “Toxin” also includes a cytostatic or cytocidal agent, a therapeutic agent or a radioactive metal ion, e.g., alpha-emitters such as, for example, ²¹³Bi, or other radioisotopes such as, for example, ¹⁰³Pd, ¹³³Xe, ¹³¹I, ¹¹¹In, ⁶⁸Ge, ⁵⁷Co, ⁶⁵Zn, ⁸⁵Sr, 32P, ³⁵S, ⁹⁰Y, ¹⁵³Sm, ¹⁵³Gd, ¹⁶⁹Yb, ⁵¹Cr, ⁵⁴Mn, ⁷⁵Se, ¹¹³Sn, ⁹⁰Yttrium, ¹¹⁷Tin, ¹⁸⁶Rhenium, ¹⁶⁶Holmium, and ¹⁸⁸Rhenium; luminescent labels, such as luminol; and fluorescent labels, such as fluorescein and rhodamine, and biotin.

[0426] In a specific embodiment, the invention provides a method for the specific destruction of cells (e.g., the destruction of tumor cells) by administering polypeptides of the invention or antibodies of the invention in association with the radioisotope 90Y. In another specific embodiment, the invention provides a method for the specific destruction of cells (e.g., the destruction of tumor cells) by administering polypeptides of the invention or antibodies of the invention in association with the radioisotope ¹¹¹In. In a further specific embodiment, the invention provides a method for the specific destruction of cells (e.g., the destruction of tumor cells) by administering polypeptides of the invention or antibodies of the invention in association with the radioisotope ¹³¹I.

[0427] Techniques known in the art may be applied to label polypeptides of the invention (including antibodies). Such techniques include, but are not limited to, the use of bifunctional conjugating agents (see e.g., U.S. Pat. Nos. 5,756,065; 5,714,631; 5,696,239; 5,652,361; 5,505,931; 5,489,425; 5,435,990; 5,428,139; 5,342,604; 5,274,119; 4,994,560; and 5,808,003; the contents of each of which are hereby incorporated by reference in its entirety).

[0428] Thus, the invention provides a diagnostic method of a disorder, which involves (a) assaying the expression level of a polypeptide of the present invention in cells or body fluid of an individual; and (b) comparing the assayed polypeptide expression level with a standard polypeptide expression level, whereby an increase or decrease in the assayed polypeptide expression level compared to the standard expression level is indicative of a disorder. With respect to cancer, the presence of a relatively high amount of transcript in biopsied tissue from an individual may indicate a predisposition for the development of the disease, or may provide a means for detecting the disease prior to the appearance of actual clinical symptoms. A more definitive diagnosis of this type may allow health professionals to employ preventative measures or aggressive treatment earlier thereby preventing the development or further progression of the cancer.

[0429] Moreover, polypeptides of the present invention can be used to treat or prevent diseases or conditions of the reproductive system such as, for example, reproductive system injury and trauma, infections, neoplastic disorders, congenital defects, and diseases or disorders which result in infertility, complications with pregnancy, labor, or parturition, postpartum difficulties,and as listed below in the section entitled “Reproductive System Disorders”. In preferred embodiments, polynucleotides expressed in a particular tissue type (see, e.g., Table 1A, column 7) are used to diagnose, detect, prevent, treat and/or prognose disorders associated with the tissue type. For example, patients can be administered a polypeptide of the present invention in an effort to replace absent or decreased levels of the polypeptide (e.g., insulin), to supplement absent or decreased levels of a different polypeptide (e.g., hemoglobin S for hemoglobin B, SOD, catalase, DNA repair proteins), to inhibit the activity of a polypeptide (e.g., an oncogene or tumor supressor), to activate the activity of a polypeptide (e.g., by binding to a receptor), to reduce the activity of a membrane bound receptor by competing with it for free ligand (e.g., soluble TNF receptors used in reducing inflammation), or to bring about a desired response (e.g., blood vessel growth inhibition, enhancement of the immune response to proliferative cells or tissues).

[0430] Similarly, antibodies directed to a polypeptide of the present invention can also be used to treat disease (as described supra, and elsewhere herein). For example, administration of an antibody directed to a polypeptide of the present invention can bind, and/or neutralize the polypeptide, and/or reduce overproduction of the polypeptide. Similarly, administration of an antibody can activate the polypeptide, such as by binding to a polypeptide bound to a membrane (receptor).

[0431] At the very least, the polypeptides of the present invention can be used as molecular weight markers on SDS-PAGE gels or on molecular sieve gel filtration columns using methods well known to those of skill in the art. Polypeptides can also be used to raise antibodies, which in turn are used to measure protein expression from a recombinant cell, as a way of assessing transformation of the host cell. Moreover, the polypeptides of the present invention can be used to test the biological activities described herein.

[0432] Diagnostic Asssays

[0433] The compounds of the present invention are useful for diagnosis, treatment, prevention and/or prognosis of various reproductive system related disorders in mammals, preferably humans. Such disorders include, but are not limited to, reproductive system injury and trauma, infections, neoplastic disorders, congenital defects, and diseases or disorders which result in infertility, complications with pregnancy, labor, or parturition, postpartum difficulties, and as listed below in the section entitled “Reproductive System Disorders”. In preferred embodiments, polynucleotides expressed in a particular tissue type (see, e.g., Table 1A, column 7) are used to diagnose, detect, prevent, treat and/or prognose disorders associated with the tissue type.

[0434] Reproductive system antigens are expressed in reproductive system. For a number of reproductive system-related disorders, substantially altered (increased or decreased) levels of reproductive system antigen gene expression can be detected in reproductive system tissue or other cells or bodily fluids (e.g., sera, plasma, urine, semen, synovial fluid or spinal fluid) taken from an individual having such a disorder, relative to a “standard” reproductive system antigen gene expression level, that is, the reproductive system antigen expression level in reproductive system tissues or bodily fluids from an individual not having the reproductive system disorder. Thus, the invention provides a diagnostic method useful during diagnosis of a reproductive system disorder, which involves measuring the expression level of the gene encoding the reproductive system associated polypeptide in reproductive system tissue or other cells or body fluid from an individual and comparing the measured gene expression level with a standard reproductive system antigens gene expression level, whereby an increase or decrease in the gene expression level(s) compared to the standard is indicative of an reproductive system disorder.

[0435] In specific embodiments, the invention provides a diagnostic method useful during diagnosis of a disorder of a normal or diseased tissue/cell source corresponding to column 7 of Table 1A, which involves measuring the expression level of the coding sequence of a polynucleotide sequence associated with this tissue/cell source as disclosed in Table 1A in the tissue/cell source or other cells or body fluid from an individual and comparing the expression level of the coding sequence with a standard expression level of the coding sequence of a polynucleotide sequence, whereby an increase or decrease in the gene expression level(s) compared to the standard is indicative of a disorder of a normal or diseased tissue/cell source corresponding to column 7 of Table 1A.

[0436] In particular, it is believed that certain tissues in mammals with cancer of cells or tissue of the reproductive system express significantly enhanced or reduced levels of normal or altered reproductive system antigen expression and mRNA encoding the reproductive system associated polypeptide when compared to a corresponding “standard” level. Further, it is believed that enhanced or depressed levels of the reproductive system associated polypeptide can be detected in certain body fluids (e.g., sera, plasma, urine, and spinal fluid) or cells or tissue from mammals with such a cancer when compared to sera from mammals of the same species not having the cancer.

[0437] For example, as disclosed herein, reproductive system associated polypeptides of the invention are expressed in tissues of the reproductive system. Accordingly, polynucleotides of the invention (e.g., polynucleotide sequences complementary to all or a portion of a reproductive system antigen mRNA nucleotide sequence of SEQ ID NO: X, nucleotide sequence encoding SEQ ID NO: Y, nucleotide sequence encoding a polypeptide encoded by SEQ ID NO: X and/or a nucleotide sequence delineated by columns 8 and 9 of Table 2) and antibodies (and antibody fragments) directed against the polypeptides of the invention may be used to quantitate or qualitate concentrations of cells of the reproductive system expressing reproductive system antigens, preferrably on their cell surfaces. These polynucleotides and antibodies additionally have diagnostic applications in detecting abnormalities in the level of reproductive system antigens gene expression, or abnormalities in the structure and/or temporal, tissue, cellular, or subcellular location of reproductive system antigens. These diagnostic assays may be performed in vivo or in vitro, such as, for example, on blood samples, biopsy tissue or autopsy tissue. In specific embodiments, polynucleotides and antibodies of the invention are used to quantitate or qualitate tissues/cells corresponding to the library source disclosed in column 7 of Table 1A expressing the corresponding reproductive system sequence disclosed in the same row of Table 1A, preferrably on their cell surface.

[0438] Thus, the invention provides a diagnostic method useful during diagnosis of a reproductive system disorder, including cancers, which involves measuring the expression level of the gene encoding the reproductive system antigen polypeptide in tissues of the reproductive system or other cells or body fluid from an individual and comparing the measured gene expression level with a standard reproductive system antigen gene expression level, whereby an increase or decrease in the gene expression level compared to the standard is indicative of a reproductive system disorder. In specific embodiments, polynucleotides and antibodies of the invention are used to quantitate or qualitate tissues/cells corresponding to the library source disclosed in column 7 of Table 1A expressing the corresponding reproductive system sequence disclosed in the same row of Table 1A, preferrably on their cell surface.

[0439] Where a diagnosis of a disorder in the reproductive system, including diagnosis of a tumor, has already been made according to conventional methods, the present invention is useful as a prognostic indicator, whereby patients exhibiting enhanced or depressed reproductive system antigen gene expression will experience a worse clinical outcome relative to patients expressing the gene at a level nearer the standard level.

[0440] By “assaying the expression level of the gene encoding the reproductive system associated polypeptide” is intended qualitatively or quantitatively measuring or estimating the level of the reproductive system antigen polypeptide or the level of the mRNA encoding the reproductive system antigen polypeptide in a first biological sample either directly (e.g., by determining or estimating absolute protein level or mRNA level) or relatively (e.g., by comparing to the reproductive system associated polypeptide level or mRNA level in a second biological sample). Preferably, the reproductive system antigen polypeptide expression level or mRNA level in the first biological sample is measured or estimated and compared to a standard reproductive system antigen polypeptide level or mRNA level, the standard being taken from a second biological sample obtained from an individual not having the disorder or being determined by averaging levels from a population of individuals not having a disorder of the reproductive system. As will be appreciated in the art, once a standard reproductive system antigen polypeptide level or mRNA level is known, it can be used repeatedly as a standard for comparison.

[0441] By “biological sample” is intended any biological sample obtained from an individual, cell line, tissue culture, or other source containing reproductive system antigen polypeptides (including portions thereof) or mRNA. As indicated, biological samples include body fluids (such as sera, plasma, urine, synovial fluid and spinal fluid) which contain cells expressing reproductive system antigen polypeptides, tissues of the reproductive system, and other tissue sources found to express the full length or fragments thereof of a reproductive system antigen. Methods for obtaining tissue biopsies and body fluids from mammals are well known in the art. Where the biological sample is to include mRNA, a tissue biopsy is the preferred source.

[0442] Total cellular RNA can be isolated from a biological sample using any suitable technique such as the single-step guanidinium-thiocyanate-phenol-chloroform method described in Chomczynski and Sacchi, Anal. Biochem. 162:156-159 (1987). Levels of mRNA encoding the reproductive system antigen polypeptides are then assayed using any appropriate method. These include Northern blot analysis, SI nuclease mapping, the polymerase chain reaction (PCR), reverse transcription in combination with the polymerase chain reaction (RT-PCR), and reverse transcription in combination with the ligase chain reaction (RT-LCR).

[0443] The present invention also relates to diagnostic assays such as quantitative and diagnostic assays for detecting levels of reproductive system antigen polypeptides, in a biological sample (e.g., cells and tissues), including determination of normal and abnormal levels of polypeptides. Thus, for instance, a diagnostic assay in accordance with the invention for detecting over-expression of reproductive system antigens compared to normal control tissue samples may be used to detect the presence of tumors. Assay techniques that can be used to determine levels of a polypeptide, such as a reproductive system antigen polypeptide of the present invention in a sample derived from a host are well-known to those of skill in the art. Such assay methods include radioimmunoassays, competitive-binding assays, Western Blot analysis and ELISA assays. Assaying reproductive system antigen polypeptide levels in a biological sample can occur using any art-known method.

[0444] Assaying reproductive system antigen polypeptide levels in a biological sample can occur using antibody-based techniques. For example, reproductive system antigen polypeptide expression in tissues can be studied with classical immunohistological methods (Jalkanen et al., J. Cell. Biol. 101:976-985 (1985); Jalkanen, M., et al., J. Cell. Biol. 105:3087-3096 (1987)). Other antibody-based methods useful for detecting reproductive system antigen polypeptide gene expression include immunoassays, such as the enzyme linked immunosorbent assay (ELISA) and the radioimmunoassay (RIA). Suitable antibody assay labels are known in the art and include enzyme labels, such as, glucose oxidase, and radioisotopes, such as iodine (¹²⁵I, ¹²¹I, carbon (¹⁴C), sulfur (³⁵S), tritium (³H), indium (¹¹²In), and technetium (^(99m)Tc), and fluorescent labels, such as fluorescein and rhodamine, and biotin.

[0445] The tissue or cell type to be analyzed will generally include those which are known, or suspected, to express the reproductive system related antigen gene (such as, for example, cells of the reproductive system or cancers of the reproductive system). The protein isolation methods employed herein may, for example, be such as those described in Harlow and Lane (Harlow, E. and Lane, D., 1988, “Antibodies: A Laboratory Manual”, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.), which is incorporated herein by reference in its entirety. The isolated cells can be derived from cell culture or from a patient. The analysis of cells taken from culture may be a necessary step in the assessment of cells that could be used as part of a cell-based gene therapy technique or, alternatively, to test the effect of compounds on the expression of the reproductive system related antigen gene.

[0446] For example, antibodies, or fragments of antibodies, such as those described herein, may be used to quantitatively or qualitatively detect the presence of reproductive system related antigen gene products or conserved variants or peptide fragments thereof. This can be accomplished, for example, by immunofluorescence techniques employing a fluorescently labeled antibody coupled with light microscopic, flow cytometric, or fluorimetric detection.

[0447] In a preferred embodiment, antibodies, or fragments of antibodies directed to any one or all of the predicted epitope domains of the reproductive system related antigen polypeptides (Shown in Table 1A, column 6) may be used to quantitatively or qualitatively detect the presence of reproductive system related antigen gene products or conserved variants or peptide fragments thereof. This can be accomplished, for example, by immunofluorescence techniques employing a fluorescently labeled antibody coupled with light microscopic, flow cytometric, or fluorimetric detection.

[0448] In an additional preferred embodiment, antibodies, or fragments of antibodies directed to a conformational epitope of a reproductive system related antigen may be used to quantitatively or qualitatively detect the presence of reproductive system related antigen gene products or conserved variants or peptide fragments thereof. This can be accomplished, for example, by immunofluorescence techniques employing a fluorescently labeled antibody coupled with light microscopic, flow cytometric, or fluorimetric detection.

[0449] The antibodies (or fragments thereof), and/or reproductive system related antigen polypeptides of the present invention may, additionally, be employed histologically, as in immunofluorescence, immunoelectron microscopy or non-immunological assays, for in situ detection of reproductive system related antigen gene products or conserved variants or peptide fragments thereof. In situ detection may be accomplished by removing a histological specimen from a patient, and applying thereto a labeled antibody or reproductive system related antigen polypeptide of the present invention. The antibody (or fragment thereof) or reproductive system related antigen polypeptide is preferably applied by overlaying the labeled antibody (or fragment) onto a biological sample. Through the use of such a procedure, it is possible to determine not only the presence of the reproductive system related antigen gene product, or conserved variants or peptide fragments, or reproductive system related antigen polypeptide binding, but also its distribution in the examined tissue. Using the present invention, those of ordinary skill will readily perceive that any of a wide variety of histological methods (such as staining procedures) can be modified in order to achieve such in situ detection.

[0450] Immunoassays and non-immunoassays for reproductive system related antigen gene products or conserved variants or peptide fragments thereof will typically comprise incubating a sample, such as a biological fluid, a tissue extract, freshly harvested cells, or lysates of cells which have been incubated in cell culture, in the presence of a detectably labeled antibody capable of binding reproductive system related antigen gene products or conserved variants or peptide fragments thereof, and detecting the bound antibody by any of a number of techniques well-known in the art.

[0451] The biological sample may be brought in contact with and immobilized onto a solid phase support or carrier such as nitrocellulose, or other solid support which is capable of immobilizing cells, cell particles or soluble proteins. The support may then be washed with suitable buffers followed by treatment with the detectably labeled anti- reproductive system related antigen antibody or detectable reproductive system related antigen polypeptide. The solid phase support may then be washed with the buffer a second time to remove unbound antibody or polypeptide. Optionally the antibody is subsequently labeled. The amount of bound label on solid support may then be detected by conventional means.

[0452] By “solid phase support or carrier” is intended any support capable of binding an antigen or an antibody. Well-known supports or carriers include glass, polystyrene, polypropylene, polyethylene, dextran, nylon, amylases, natural and modified celluloses, polyacrylamides, gabbros, and magnetite. The nature of the carrier can be either soluble to some extent or insoluble for the purposes of the present invention. The support material may have virtually any possible structural configuration so long as the coupled molecule is capable of binding to an antigen or antibody. Thus, the support configuration may be spherical, as in a bead, or cylindrical, as in the inside surface of a test tube, or the external surface of a rod. Alternatively, the surface may be flat such as a sheet, test strip, etc. Preferred supports include polystyrene beads. Those skilled in the art will know many other suitable carriers for binding antibody or antigen, or will be able to ascertain the same by use of routine experimentation.

[0453] The binding activity of a given lot of anti-reproductive system related antigen antibody or reproductive system related antigen polypeptide may be determined according to well known methods. Those skilled in the art will be able to determine operative and optimal assay conditions for each determination by employing routine experimentation.

[0454] In addition to assaying reproductive system related antigen polypeptide levels or polynucleotide levels in a biological sample obtained from an individual, reproductive system related antigen polypeptide or polynucleotide can also be detected in vivo by imaging. For example, in one embodiment of the invention, reproductive system related antigen polypeptide and/or anti-reproductive system related antigen antibodies are used to image reproductive system diseased cells, such as neoplasms. In another embodiment, reproductive system related antigen polynucleotides of the invention (e.g., polynucleotides complementary to all or a portion of reproductive system related antigen mRNA) and/or anti-reproductive system related antigen antibodies (e.g., antibodies directed to any one or a combination of the epitopes of reproductive system related antigens, antibodies directed to a conformational epitope of reproductive system related antigens, antibodies directed to the full length polypeptide expressed on the cell surface of a mammalian cell) are used to image diseased or neoplastic cells of the reproductive system.

[0455] Antibody labels or markers for in vivo imaging of reproductive system related antigen polypeptides include those detectable by X-radiography, NMR, MRI, CAT-scans or ESR. For X-radiography, suitable labels include radioisotopes such as barium or cesium, which emit detectable radiation but are not overtly harmful to the subject. Suitable markers for NMR and ESR include those with a detectable characteristic spin, such as deuterium, which may be incorporated into the antibody by labeling of nutrients for the relevant hybridoma. Where in vivo imaging is used to detect enhanced levels of reproductive system related antigen polypeptides for diagnosis in humans, it may be preferable to use human antibodies or “humanized” chimeric monoclonal antibodies. Such antibodies can be produced using techniques described herein or otherwise known in the art. For example methods for producing chimeric antibodies are known in the art. See, for review, Morrison, Science 229:1202 (1985); Oi et al., BioTechniques 4:214 (1986); Cabilly et al., U.S. Pat. No. 4,816,567; Taniguchi et al., EP 171496; Morrison et al., EP 173494; Neuberger et al., WO 8601533; Robinson et al., WO 8702671; Boulianne et al., Nature 312:643 (1984); Neuberger et al., Nature 314:268 (1985).

[0456] Additionally, any reproductive system related antigen polypeptides whose presence can be detected, can be administered. For example, reproductive system related antigen polypeptides labeled with a radio-opaque or other appropriate compound can be administered and visualized in vivo, as discussed, above for labeled antibodies. Further such reproductive system related antigen polypeptides can be utilized for in vitro diagnostic procedures.

[0457] A reproductive system related antigen polypeptide-specific antibody or antibody fragment which has been labeled with an appropriate detectable imaging moiety, such as a radioisotope (for example, ¹³¹I, ¹¹²In, ^(99m)Tc), a radio-opaque substance, or a material detectable by nuclear magnetic resonance, is introduced (for example, parenterally, subcutaneously or intraperitoneally) into the mammal to be examined for a disorder of the reproductive system. It will be understood in the art that the size of the subject and the imaging system used will determine the quantity of imaging moiety needed to produce diagnostic images. In the case of a radioisotope moiety, for a human subject, the quantity of radioactivity injected will normally range from about 5 to 20 millicuries of ^(99m)Tc. The labeled antibody or antibody fragment will then preferentially accumulate at the location of cells which contain reproductive system related antigen protein. In vivo tumor imaging is described in S. W. Burchiel et al., “Immunopharmacokinetics of Radiolabeled Antibodies and Their Fragments” (Chapter 13 in Tumor Imaging: The Radiochemical Detection of Cancer, S. W. Burchiel and B. A. Rhodes, eds., Masson Publishing Inc. (1982)).

[0458] With respect to antibodies, one of the ways in which the anti-reproductive system related antigen antibody can be detectably labeled is by linking the same to an enzyme and using the linked product in an enzyme immunoassay (EIA) (Voller, A., “The Enzyme Linked Immunosorbent Assay (ELISA)”, 1978, Diagnostic Horizons 2:1-7, Microbiological Associates Quarterly Publication, Walkersville, Md.); Voller et al., J. Clin. Pathol. 31:507-520 (1978); Butler, J. E., Meth. Enzymol. 73:482-523 (1981); Maggio, E. (ed.), 1980, Enzyme Immunoassay, CRC Press, Boca Raton, Fla.,; Ishikawa, E. et al., (eds.), 1981, Enzyme Immunoassay, Kgaku Shoin, Tokyo). The enzyme which is bound to the antibody will react with an appropriate substrate, preferably a chromogenic substrate, in such a manner as to produce a chemical moiety which can be detected, for example, by spectrophotometric, fluorimetric or by visual means. Enzymes which can be used to detectably label the antibody include, but are not limited to, malate dehydrogenase, staphylococcal nuclease, delta-5-steroid isomerase, yeast alcohol dehydrogenase, alpha-glycerophosphate, dehydrogenase, triose phosphate isomerase, horseradish peroxidase, alkaline phosphatase, asparaginase, glucose oxidase, beta-galactosidase, ribonuclease, urease, catalase, glucose-6-phosphate dehydrogenase, glucoamylase and acetylcholinesterase. Additionally, the detection can be accomplished by calorimetric methods which employ a chromogenic substrate for the enzyme. Detection may also be accomplished by visual comparison of the extent of enzymatic reaction of a substrate in comparison with similarly prepared standards.

[0459] Detection may also be accomplished using any of a variety of other immunoassays. For example, by radioactively labeling the antibodies or antibody fragments, it is possible to detect reproductive system related antigens through the use of a radioimmunoassay (RIA) (see, for example, Weintraub, B., Principles of Radioimmunoassays, Seventh Training Course on Radioligand Assay Techniques, The Endocrine Society, March, 1986, which is incorporated by reference herein). The radioactive isotope can be detected by means including, but not limited to, a gamma counter, a scintillation counter, or autoradiography.

[0460] It is also possible to label the antibody with a fluorescent compound. When the fluorescently labeled antibody is exposed to light of the proper wave length, its presence can then be detected due to fluorescence. Among the most commonly used fluorescent labeling compounds are fluorescein isothiocyanate, rhodamine, phycoerythrin, phycocyanin, allophycocyanin, ophthaldehyde and fluorescamine.

[0461] The antibody can also be detectably labeled using fluorescence emitting metals such as ¹⁵²Eu, or others of the lanthanide series. These metals can be attached to the antibody using such metal chelating groups as diethylenetriaminepentacetic acid (DTPA) or ethylenediaminetetraacetic acid (EDTA).

[0462] The antibody also can be detectably labeled by coupling it to a chemiluminescent compound. The presence of the chemiluminescent-tagged antibody is then determined by detecting the presence of luminescence that arises during the course of a chemical reaction. Examples of particularly useful chemiluminescent labeling compounds are luminol, isoluminol, theromatic acridinium ester, imidazole, acridinium salt and oxalate ester.

[0463] Likewise, a bioluminescent compound may be used to label the antibody of the present invention. Bioluminescence is a type of chemiluminescence found in biological systems in, which a catalytic protein increases the efficiency of the chemiluminescent reaction. The presence of a bioluminescent protein is determined by detecting the presence of luminescence. Important bioluminescent compounds for purposes of labeling are luciferin, luciferase and aequorin.

[0464] Methods for Detecting Diseases of the Reproductive Systems Including Cancer

[0465] In general, a disease of the reproductive system or cancer may be detected in a patient based on the presence of one or more reproductive system related antigen proteins of the invention and/or polynucleotides encoding such proteins in a biological sample (for example, blood, sera, urine, and/or tumor biopsies) obtained from the patient. In other words, such proteins and/or polynucleotides may be used as markers to indicate the presence or absence of a reproductive system disease or disorder, including cancer. Cancers that may be diagnosed, and/or prognosed using the compositions of the invention include but are not limited to, cancers of the reproductive system. In addition, such proteins and/or polynucleotidse may be useful for the detection of other diseases and cancers, including cancers of tissues/cells corresponding to the library source disclosed in column 7 of Table 1A expressing the corresponding reproductive system related sequence disclosed in the same row of Table 1A. The binding agents provided herein generally permit detection of the level of antigen that binds to the agent in the biological sample. Polynucleotide primers and probes may be used to detect the level of mRNA encoding reproductive system related antigen polypeptides, which is also indicative of the presence or absence of a reproductive system disease or disorder, including cancer. In general, reproductive system related antigen polypeptides should be present at a level that is at least three fold higher in diseased tissue than in normal tissue.

[0466] There are a variety of assay formats known to those of ordinary skill in the art for using a binding agent to detect polypeptide markers in a sample. See, e.g., Harlow and Lane, supra. In general, the presence or absence of a reproductive system disease in a patient may be determined by (a) contacting a biological sample obtained from a patient with a binding agent; (b) detecting in the sample a level of polypeptide that binds to the binding agent; and (c) comparing the level of polypeptide with a predetermined cut-off value.

[0467] In a preferred embodiment, the assay involves the use of binding agent immobilized on a solid support to bind to and remove the reproductive system related antigen polypeptide of the invention from the remainder of the sample. The bound polypeptide may then be detected using a detection reagent that contains a reporter group and specifically binds to the binding agent/polypeptide complex. Such detection reagents may comprise, for example, a binding agent that specifically binds to the polypeptide or an antibody or other agent that specifically binds to the binding agent, such as an anti-immunoglobulin, protein G, protein A or a lectin. Alternatively, a competitive assay may be utilized, in which a polypeptide is labeled with a reporter group and allowed to bind to the immobilized binding agent after incubation of the binding agent with the sample. The extent to which components of the sample inhibit the binding of the labeled polypeptide to the binding agent is indicative of the reactivity of the sample with the immobilized binding agent. Suitable polypeptides for use within such assays include reproductive system related antigen polypeptides and portions thereof, or antibodies, to which the binding agent binds, as described above.

[0468] The solid support may be any material known to those of skill in the art to which reproductive system related antigen polypeptides of the invention may be attached. For example, the solid support may be a test well in a microtiter plate or a nitrocellulose or other suitable membrane. Alternatively, the support may be a bead or disc, such as glass fiberglass, latex or a plastic material such as polystyrene or polyvinylchloride. The support may also be a magnetic particle or a fiber optic sensor, such as those disclosed, for example, in U.S. Pat. No. 5,359,681. The binding agent may be immobilized on the solid support using a variety of techniques known to those of skill in the art, which are amply described in the patent and scientific literature. In the context of the present invention, the term “immobilization” refers to both noncovalent association, such as adsorption, and covalent attachment (which may be a direct linkage between the agent and functional groups on the support or may be a linkage by way of a cross-linking agent). Immobilization by adsorption to a well in a microtiter plate or to a membrane is preferred. In such cases, adsorption may be achieved by contacting the binding agent, in a suitable buffer, with the solid support for the suitable amount of time. The contact time varies with temperature, but is typically between about 1 hour and about 1 day. In general, contacting a well of plastic microtiter plate (such as polystyrene or polyvinylchloride) with an amount of binding agent ranging from about 10 ng to about 10 ug, and preferably about 100 ng to about 1 ug, is sufficient to immobilize an adequate amount of binding agent.

[0469] Covalent attachment of binding agent to a solid support may generally be achieved by first reacting the support with a bifunctional reagent that will react with both the support and a functional group, such as a hydroxyl or amino group, on the binding agent. For example, the binding agent may be covalently attached to supports having an appropriate polymer coating using benzoquinone or by condensation of an aldehyde group on the support with an amine and an active hydrogen on the binding partner (see, e.g., Pierce Immunotechnology Catalog and Handbook, 1991, at A12-A13).

[0470] Gene Therapy Methods

[0471] Also encompassed by the present invention are gene therapy methods for treating or preventing disorders, diseases and conditions. The gene therapy methods relate to the introduction of nucleic acid (DNA, RNA and antisense DNA or RNA) sequences into an animal to achieve expression of a reproductive system related antigen of the present invention. This method requires a polynucleotide which codes for a polypeptide of the present invention operatively linked to a promoter and any other genetic elements necessary for the expression of the polypeptide by the target tissue. Such gene therapy and delivery techniques are known in the art, see, for example, WO90/11092, which is herein incorporated by reference.

[0472] Thus, for example, cells from a patient may be engineered with a polynucleotide (DNA or RNA) comprising a promoter operably linked to a polynucleotide of the present invention ex vivo, with the engineered cells then being provided to a patient to be treated with the polypeptide of the present invention. Such methods are well-known in the art. For example, see Belldegrun, A., et al., J. Natl. Cancer Inst. 85: 207-216 (1993); Ferrantini, M. et al., Cancer Research 53: 1107-1112 (1993); Ferrantini, M. et al., J. Immunology 153: 4604-4615 (1994); Kaido, T., et al., Int. J. Cancer 60: 221-229 (1995); Ogura, H., et al., Cancer Research 50: 5102-5106 (1990); Santodonato, L., et al., Human Gene Therapy 7:1-10 (1996); Santodonato, L., et al., Gene Therapy 4:1246-1255 (1997); and Zhang, J. F. et al., Cancer Gene Therapy 3: 31-38 (1996)), which are herein incorporated by reference. In one embodiment, the cells which are engineered are arterial cells. The arterial cells may be reintroduced into the patient through direct injection to the artery, the tissues surrounding the artery, or through catheter injection.

[0473] As discussed in more detail below, the polynucleotide constructs can be delivered by any method that delivers injectable materials to the cells of an animal, such as, injection into the interstitial space of tissues (heart, muscle, skin, lung, liver, and the like). The polynucleotide constructs may be delivered in a pharmaceutically acceptable liquid or aqueous carrier.

[0474] In one embodiment, the polynucleotide of the present invention is delivered as a naked polynucleotide. The term “naked” polynucleotide, DNA or RNA refers to sequences that are free from any delivery vehicle that acts to assist, promote or facilitate entry into the cell, including viral sequences, viral particles, liposome formulations, lipofectin or precipitating agents and the like. However, the polynucleotide of the present invention can also be delivered in liposome formulations and lipofectin formulations and the like can be prepared by methods well known to those skilled in the art. Such methods are described, for example, in U.S. Pat. Nos. 5,593,972, 5,589,466, and 5,580,859, which are herein incorporated by reference.

[0475] The polynucleotide vector constructs used in the gene therapy method are preferably constructs that will not integrate into the host genome nor will they contain sequences that allow for replication. Appropriate vectors include pWLNEO, pSV2CAT, pOG44, pXT1 and pSG available from Stratagene; pSVK3, pBPV, pMSG and pSVL available from Pharmacia; and pEF1/V5, pcDNA3.1, and pRc/CMV2 available from Invitrogen. Other suitable vectors will be readily apparent to the skilled artisan.

[0476] Any strong promoter known to those skilled in the art can be used for driving the expression of the polynucleotide sequence. Suitable promoters include adenoviral promoters, such as the adenoviral major late promoter; or heterologous promoters, such as the cytomegalovirus (CMV) promoter; the respiratory syncytial virus (RSV) promoter; inducible promoters, such as the MMT promoter, the metallothionein promoter; heat shock promoters; the albumin promoter; the ApoAI promoter; human globin promoters; viral thymidine kinase promoters, such as the Herpes Simplex thymidine kinase promoter; retroviral LTRs; the b-actin promoter; and human growth hormone promoters. The promoter also may be the native promoter for the polynucleotide of the present invention.

[0477] Unlike other gene therapy techniques, one major advantage of introducing naked nucleic acid sequences into target cells is the transitory nature of the polynucleotide synthesis in the cells. Studies have shown that non-replicating DNA sequences can be introduced into cells to provide production of the desired polypeptide for periods of up to six months.

[0478] The polynucleotide construct can be delivered to the interstitial space of tissues within the an animal, including of muscle, skin, brain, lung, liver, spleen, bone marrow, thymus, heart, lymph, blood, bone, cartilage, pancreas, kidney, gall bladder, stomach, intestine, testis, ovary, uterus, rectum, nervous system, eye, gland, and connective tissue. Interstitial space of the tissues comprises the intercellular, fluid, mucopolysaccharide matrix among the reticular fibers of organ tissues, elastic fibers in the walls of vessels or chambers, collagen fibers of fibrous tissues, or that same matrix within connective tissue ensheathing muscle cells or in the lacunae of bone. It is similarly the space occupied by the plasma of the circulation and the lymph fluid of the lymphatic channels. Delivery to the interstitial space of muscle tissue is preferred for the reasons discussed below. They may be conveniently delivered by injection into the tissues comprising these cells. They are preferably delivered to and expressed in persistent, non-dividing cells which are differentiated, although delivery and expression may be achieved in non-differentiated or less completely differentiated cells, such as, for example, stem cells of blood or skin fibroblasts. In vivo muscle cells are particularly competent in their ability to take up and express polynucleotides.

[0479] For the naked nucleic acid sequence injection, an effective dosage amount of DNA or RNA will be in the range of from about 0.05 mg/kg body weight to about 50 mg/kg body weight. Preferably the dosage will be from about 0.005 mg/kg to about 20 mg/kg and more preferably from about 0.05 mg/kg to about 5 mg/kg. Of course, as the artisan of ordinary skill will appreciate, this dosage will vary according to the tissue site of injection. The appropriate and effective dosage of nucleic acid sequence can readily be determined by those of ordinary skill in the art and may depend on the condition being treated and the route of administration.

[0480] The preferred route of administration is by the parenteral route of injection into the interstitial space of tissues. However, other parenteral routes may also be used, such as, inhalation of an aerosol formulation particularly for delivery to lungs or bronchial tissues, throat or mucous membranes of the nose. In addition, naked DNA constructs can be delivered to arteries during angioplasty by the catheter used in the procedure.

[0481] The naked polynucleotides are delivered by any method known in the art, including, but not limited to, direct needle injection at the delivery site, intravenous injection, topical administration, catheter infusion, and so-called “gene guns”. These delivery methods are known in the art.

[0482] The constructs may also be delivered with delivery vehicles such as viral sequences, viral particles, liposome formulations, lipofectin, precipitating agents, etc. Such methods of delivery are known in the art.

[0483] In certain embodiments, the polynucleotide constructs are complexed in a liposome preparation. Liposomal preparations for use in the instant invention include cationic (positively charged), anionic (negatively charged) and neutral preparations. However, cationic liposomes are particularly preferred because a tight charge complex can be formed between the cationic liposome and the polyanionic nucleic acid. Cationic liposomes have been shown to mediate intracellular delivery of plasmid DNA (Felgner et al., Proc. Natl. Acad. Sci. USA (1987) 84:7413-7416, which is herein incorporated by reference); mRNA (Malone et al., Proc. Natl. Acad. Sci. USA (1989) 86:6077-6081, which is herein incorporated by reference); and purified transcription factors (Debs et al., J. Biol. Chem. (1990) 265:10189-10192, which is herein incorporated by reference), in functional form.

[0484] Cationic liposomes are readily available. For example, N[1-2,3-dioleyloxy)propyl]-N,N,N-triethylammonium (DOTMA) liposomes are particularly useful and are available under the trademark Lipofectin, from GIBCO BRL, Grand Island, N.Y., (see, also, Felgner et al., Proc. Natl Acad. Sci. USA (1987) 84:7413-7416, which is herein incorporated by reference). Other commercially available liposomes include transfectace (DDAB/DOPE) and DOTAP/DOPE (Boehringer).

[0485] Other cationic liposomes can be prepared from readily available materials using techniques well known in the art. See, e.g. PCT Publication No. WO 90/11092 (which is herein incorporated by reference) for a description of the synthesis of DOTAP (1,2-bis(oleoyloxy)-3-(trimethylammonio)propane) liposomes. Preparation of DOTMA liposomes is explained in the literature, see, e.g., P. Felgner et al., Proc. Natl. Acad. Sci. USA 84:7413-7417, which is herein incorporated by reference. Similar methods can be used to prepare liposomes from other cationic lipid materials.

[0486] Similarly, anionic and neutral liposomes are readily available, such as from Avanti Polar Lipids (Birmingham, Ala.), or can be easily prepared using readily available materials. Such materials include phosphatidyl choline, cholesterol, phosphatidyl ethanolamine, dioleoylphosphatidyl choline (DOPC), dioleoylphosphatidyl glycerol (DOPG), dioleoylphoshatidyl ethanolamine (DOPE), among others. These materials can also be mixed with the DOTMA and DOTAP starting materials in appropriate ratios. Methods for making liposomes using these materials are well known in the art.

[0487] For example, commercially dioleoylphosphatidyl choline (DOPC), dioleoylphosphatidyl glycerol (DOPG), and dioleoylphosphatidyl ethanolamine (DOPE) can be used in various combinations to make conventional liposomes, with or without the addition of cholesterol. Thus, for example, DOPG/DOPC vesicles can be prepared by drying 50 mg each of DOPG and DOPC under a stream of nitrogen gas into a sonication vial. The sample is placed under a vacuum pump overnight and is hydrated the following day with deionized water. The sample is then sonicated for 2 hours in a capped vial, using a Heat Systems model 350 sonicator equipped with an inverted cup (bath type) probe at the maximum setting while the bath is circulated at 15EC. Alternatively, negatively charged vesicles can be prepared without sonication to produce multilamellar vesicles or by extrusion through nucleopore membranes to produce unilamellar vesicles of discrete size. Other methods are known and available to those of skill in the art.

[0488] The liposomes can comprise multilamellar vesicles (MLVs), small unilamellar vesicles (SUVs), or large unilamellar vesicles (LUVs), with SUVs being preferred. The various liposome-nucleic acid complexes are prepared using methods well known in the art. See, e.g., Straubinger et al., Methods of Immunology (1983), 101:512-527, which is herein incorporated by reference. For example, MLVs containing nucleic acid can be prepared by depositing a thin film of phospholipid on the walls of a glass tube and subsequently hydrating with a solution of the material to be encapsulated. SUVs are prepared by extended sonication of MLVs to produce a homogeneous population of unilamellar liposomes. The material to be entrapped is added to a suspension of preformed MLVs and then sonicated. When using liposomes containing cationic lipids, the dried lipid film is resuspended in an appropriate solution such as sterile water or an isotonic buffer solution such as 10 mM Tris/NaCl, sonicated, and then the preformed liposomes are mixed directly with the DNA. The liposome and DNA form a very stable complex due to binding of the positively charged liposomes to the cationic DNA. SUVs find use with small nucleic acid fragments. LUVs are prepared by a number of methods, well known in the art. Commonly used methods include Ca²⁻-EDTA chelation (Papahadjopoulos et al., Biochim. Biophys. Acta (1975) 394:483; Wilson et al., Cell 17:77 (1979); ether injection (Deamer, D. and Bangham, A., Biochim. Biophys. Acta 443:629 (1976); Ostro et al., Biochem. Biophys. Res. Commun. 76:836 (1977); Fraley et al., Proc. Natl. Acad. Sci. USA 76:3348 (1979)); detergent dialysis (Enoch, H. and Strittmatter, P., Proc. Natl. Acad. Sci. USA 76:145 (1979)); and reverse-phase evaporation (REV) (Fraley et al., J. Biol. Chem. 255:10431 (1980); Szoka et al., Proc. Natl. Acad. Sci. USA 75:145 (1978); Schaefer-Ridder et al., Science 215:166 (1982)), which are herein incorporated by reference.

[0489] Generally, the ratio of DNA to liposomes will be from about 10:1 to about 1:10. Preferably, the ration will be from about 5:1 to about 1:5. More preferably, the ration will be about 3:1 to about 1:3. Still more preferably, the ratio will be about 1: 1.

[0490] U.S. Pat. No. 5,676,954 (which is herein incorporated by reference) reports on the injection of genetic material, complexed with cationic liposomes carriers, into mice. U.S. Pat. Nos. 4,897,355, 4,946,787, 5,049,386, 5,459,127, 5,589,466, 5,693,622, 5,580,859, 5,703,055, and international publication no. WO 94/9469 (which are herein incorporated by reference) provide cationic lipids for use in transfecting DNA into cells and mammals. U.S. Pat. Nos. 5,589,466, 5,693,622, 5,580,859, 5,703,055, and International Publication No. WO 94/9469 provide methods for delivering DNA-cationic lipid complexes to mammals.

[0491] In certain embodiments, cells are engineered, ex vivo or in vivo, using a retroviral particle containing RNA which comprises a sequence encoding a polypeptide of the present invention. Retroviruses from which the retroviral plasmid vectors may be derived include, but are not limited to, Moloney Murine Leukemia Virus, spleen necrosis virus, Rous sarcoma Virus, Harvey Sarcoma Virus, avian leukosis virus, gibbon ape leukemia virus, human immunodeficiency virus, Myeloproliferative Sarcoma Virus, and mammary tumor virus.

[0492] The retroviral plasmid vector is employed to transduce packaging cell lines to form producer cell lines. Examples of packaging cells which may be transfected include, but are not limited to, the PE501, PA317, R-2, R-AM, PA12, T19-14X, VT-19-17-H2, RCRE, RCRIP, GP+E-86, GP+envAm12, and DAN cell lines as described in Miller, Human Gene Therapy 1:5-14 (1990), which is incorporated herein by reference in its entirety. The vector may transduce the packaging cells through any means known in the art. Such means include, but are not limited to, electroporation, the use of liposomes, and CaPO₄ precipitation. In one alternative, the retroviral plasmid vector may be encapsulated into a liposome, or coupled to a lipid, and then administered to a host.

[0493] The producer cell line generates infectious retroviral vector particles which include polynucleotide encoding a polypeptide of the present invention. Such retroviral vector particles then may be employed, to transduce eukaryotic cells, either in vitro or in vivo. The transduced eukaryotic cells will express a polypeptide of the present invention.

[0494] In certain other embodiments, cells are engineered, ex vivo or in vivo, with polynucleotide contained in an adenovirus vector. Adenovirus can be manipulated such that it encodes and expresses a polypeptide of the present invention, and at the same time is inactivated in terms of its ability to replicate in a normal lytic viral life cycle. Adenovirus expression is achieved without integration of the viral DNA into the host cell chromosome, thereby alleviating concerns about insertional mutagenesis. Furthermore, adenoviruses have been used as live enteric vaccines for many years with an excellent safety profile (Schwartz, et al., Am. Rev. Respir. Dis.109:233-238 (1974)). Finally, adenovirus mediated gene transfer has been demonstrated in a number of instances including transfer of alpha-1-antitrypsin and CFTR to the lungs of cotton rats (Rosenfeld et al., Science 252:431-434 (1991); Rosenfeld et al., Cell 68:143-155 (1991)). Furthermore, extensive studies to attempt to establish adenovirus as a causative agent in human cancer were uniformly negative (Green et al., Proc. Natl. Acad. Sci. USA 76:6606 (1979)).

[0495] Suitable adenoviral vectors useful in the present invention are described, for example, in Kozarsky and Wilson, Curr. Opin. Genet. Devel. 3:499-503 (1993); Rosenfeld et al., Cell 68:143-155 (1992); Engelhardt et al., Human Genet. Ther. 4:759-769 (1993); Yang et al., Nature Genet. 7:362-369 (1994); Wilson et al., Nature 365:691-692 (1993); and U.S. Pat. No. 5,652,224, which are herein incorporated by reference. For example, the adenovirus vector Ad2 is useful and can be grown in human 293 cells. These cells contain the E1 region of adenovirus and constitutively express E1a and E1b, which complement the defective adenoviruses by providing the products of the genes deleted from the vector. In addition to Ad2, other varieties of adenovirus (e.g., Ad3, Ad5, and Ad7) are also useful in the present invention.

[0496] Preferably, the adenoviruses used in the present invention are replication deficient. Replication deficient adenoviruses require the aid of a helper virus and/or packaging cell line to form infectious particles. The resulting virus is capable of infecting cells and can express a polynucleotide of interest which is operably linked to a promoter, but cannot replicate in most cells. Replication deficient adenoviruses may be deleted in one or more of all or a portion of the following genes: E1a, E1b, E3, E4, E2a, or L1 through L5.

[0497] In certain other embodiments, the cells are engineered, ex vivo or in vivo, using an adeno-associated virus (AAV). AAVs are naturally occurring defective viruses that require helper viruses to produce infectious particles (Muzyczka, N., Curr. Topics in Microbiol. Immunol. 158:97 (1992)). It is also one of the few viruses that may integrate its DNA into non-dividing cells. Vectors containing as little as 300 base pairs of AAV can be packaged and can integrate, but space for exogenous DNA is limited to about 4.5 kb. Methods for producing and using such AAVs are known in the art. See, for example, U.S. Pat. Nos. 5,139,941, 5,173,414, 5,354,678, 5,436,146, 5,474,935, 5,478,745, and 5,589,377.

[0498] For example, an appropriate AAV vector for use in the present invention will include all the sequences necessary for DNA replication, encapsidation, and host-cell integration. The polynucleotide construct is inserted into the AAV vector using standard cloning methods, such as those found in Sambrook et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press (1989). The recombinant AAV vector is then transfected into packaging cells which are infected with a helper virus, using any standard technique, including lipofection, electroporation, calcium phosphate precipitation, etc. Appropriate helper viruses include adenoviruses, cytomegaloviruses, vaccinia viruses, or herpes viruses. Once the packaging cells are transfected and infected, they will produce infectious AAV viral particles which contain the polynucleotide construct. These viral particles are then used to transduce eukaryotic cells, either ex vivo or in vivo. The transduced cells will contain the polynucleotide construct integrated into its genome, and will express a polypeptide of the invention.

[0499] Another method of gene therapy involves operably associating heterologous control regions and endogenous reproductive system related antigen polynucleotide sequences (e.g., encoding a reproductive system related antigen polypeptide of the present invention) via homologous recombination (see, e.g., U.S. Pat. No. 5,641,670, issued Jun. 24, 1997; International Publication No. WO 96/29411, published Sep. 26, 1996; International Publication No. WO 94/12650, published Aug. 4, 1994; Koller et al., Proc. Natl. Acad. Sci. USA 86:8932-8935 (1989); and Zijlstra et al., Nature 342:435-438 (1989), which are herein incorporated by reference. This method involves the activation of a gene which is present in the target cells, but which is not normally expressed in the cells, or is expressed at a lower level than desired.

[0500] Polynucleotide constructs are made, using standard techniques known in the art, which contain the promoter with targeting sequences flanking the promoter. Suitable promoters are described herein. The targeting sequence is sufficiently complementary to an endogenous sequence to permit homologous recombination of the promoter-targeting sequence with the endogenous sequence. The targeting sequence will be sufficiently near the 5′ end of the desired endogenous polynucleotide sequence so the promoter will be operably linked to the endogenous sequence upon homologous recombination.

[0501] The promoter and the targeting sequences can be amplified using PCR. Preferably, the amplified promoter contains distinct restriction enzyme sites on the 5′ and 3′ ends. Preferably, the 3′ end of the first targeting sequence contains the same restriction enzyme site as the 5′ end of the amplified promoter and the 5′ end of the second targeting sequence contains the same restriction site as the 3′ end of the amplified promoter. The amplified promoter and targeting sequences are digested and ligated together.

[0502] The promoter-targeting sequence construct is delivered to the cells, either as naked polynucleotide, or in conjunction with transfection-facilitating agents, such as liposomes, viral sequences, viral particles, whole viruses, lipofection, precipitating agents, etc., described in more detail above. The P promoter-targeting sequence can be delivered by any method, included direct needle injection, intravenous injection, topical administration, catheter infusion, particle accelerators, etc. The methods are described in more detail below.

[0503] The promoter-targeting sequence construct is taken up by cells. Homologous recombination between the construct and the endogenous sequence takes place, such that an endogenous sequence is placed under the control of the promoter. The promoter then drives the expression of the endogenous sequence.

[0504] The polynucleotide encoding a polypeptide of the present invention may contain a secretory signal sequence that facilitates secretion of the protein. Typically, the signal sequence is positioned in the coding region of the polynucleotide to be expressed towards or at the 5′ end of the coding region. The signal sequence may be homologous or heterologous to the reproductive system related antigen polynucleotide of interest and may be homologous or heterologous to the cells to be transfected. Additionally, the signal sequence may be chemically synthesized using methods known in the art.

[0505] Any mode of administration of any of the above-described polynucleotides constructs can be used so long as the mode results in the expression of one or more molecules in an amount sufficient to provide a therapeutic effect. This includes direct needle injection, systemic injection, catheter infusion, biolistic injectors, particle accelerators (i.e., “gene guns”), gelfoam sponge depots, other commercially available depot materials, osmotic pumps (e.g., Alza minipumps), oral or suppositorial solid (tablet or pill) pharmaceutical formulations, and decanting or topical applications during surgery. For example, direct injection of naked calcium phosphate-precipitated plasmid into rat liver and rat spleen or a protein-coated plasmid into the portal vein has resulted in gene expression of the foreign gene in the rat livers (Kaneda et al., Science 243:375 (1989)).

[0506] A preferred method of local administration is by direct injection. Preferably, a recombinant molecule of the present invention complexed with a delivery vehicle is administered by direct injection into or locally within the area of arteries. Administration of a composition locally within the area of arteries refers to injecting the composition centimeters and preferably, millimeters within arteries.

[0507] Another method of local administration is to contact a polynucleotide construct of the present invention in or around a surgical wound. For example, a patient can undergo surgery and the polynucleotide construct can be coated on the surface of tissue inside the wound or the construct can be injected into areas of tissue inside the wound.

[0508] Therapeutic compositions useful in systemic administration, include recombinant molecules of the present invention complexed to a targeted delivery vehicle of the present invention. Suitable delivery vehicles for use with systemic administration comprise liposomes comprising ligands for targeting the vehicle to a particular site. In specific embodiments, suitable delivery vehicles for use with systemic administration comprise liposomes comprising polypeptides of the invention for targeting the vehicle to a particular site.

[0509] Preferred methods of systemic administration, include intravenous injection, aerosol, oral and percutaneous (topical) delivery. Intravenous injections can be performed using methods standard in the art. Aerosol delivery can also be performed using methods standard in the art (see, for example, Stribling et al., Proc. Natl. Acad. Sci. USA 189:11277-11281, 1992, which is incorporated herein by reference). Oral delivery can be performed by complexing a polynucleotide construct of the present invention to a carrier capable of withstanding degradation by digestive enzymes in the gut of an animal. Examples of such carriers, include plastic capsules or tablets, such as those known in the art. Topical delivery can be performed by mixing a polynucleotide construct of the present invention with a lipophilic reagent (e.g., DMSO) that is capable of passing into the skin.

[0510] Determining an effective amount of substance to be delivered can depend upon a number of factors including, for example, the chemical structure and biological activity of the substance, the age and weight of the animal, the precise condition requiring treatment and its severity, and the route of administration. The frequency of treatments depends upon a number of factors, such as the amount of polynucleotide constructs administered per dose, as well as the health and history of the subject. The precise amount, number of doses, and timing of doses will be determined by the attending physician or veterinarian.

[0511] Therapeutic compositions of the present invention can be administered to any animal, preferably to mammals and birds. Preferred mammals include humans, dogs, cats, mice, rats, rabbits sheep, cattle, horses and pigs, with humans being particularly preferred.

[0512] Biological Activities

[0513] Polynucleotides or polypeptides, or agonists or antagonists of the present invention, can be used in assays to test for one or more biological activities. If these polynucleotides or polypeptides, or agonists or antagonists of the present invention, do exhibit activity in a particular assay, it is likely that these molecules may be involved in the diseases associated with the biological activity. Thus, the polynucleotides and polypeptides, and agonists or antagonists could be used to treat, prevent diagnose and/or prognose the associated disease.

[0514] The reproductive system related antigen polynucleotides and polypeptides of the invention are predicted to have predominant expression in tissues of the reproductive system.

[0515] Thus, the reproductive system related antigens of the invention may be useful as therapeutic molecules. Each would be useful for diagnosis, detection, treatment and/or prevention of diseases or disorders of the reproductive system, including, for example, injury and trauma, infections, neoplastic disorders, congenital defects, and diseases or disorders which result in infertility, complications with pregnancy, labor, or parturition, postpartum difficulties, and/or as described below in the section entitled “Reproductive System Disorders”.

[0516] In a preferred embodiment, polynucleotides of the invention (e.g., a nucleic acid sequence of SEQ ID NO: X or the complement thereof, or the cDNA sequence contained in Clone ID NO: Z, or fragments or variants thereof) and/or polypeptides of the invention (e.g., an amino acid sequence contained in SEQ ID NO: Y, an amino acid sequence encoded by SEQ ID NO: X, or the complement threof, an amino acid sequence encoded by the cDNA sequence contained in Clone ID NO: Z and fragments or variants thereof as described herein) are useful for the diagnosis, detection, treatement, and/or prevention of diseases or disorders of the tissues/cells corresponding to the library source disclosed in column 7 of Table 1A expressing the corresponding reproductive system related sequence disclosed in the same row of Table 1A.

[0517] Particularly, the reproductive system related antigens may be a useful therapeutic for cancers of the reproductive system. Treatment, diagnosis, detection, and/or prevention of disorders of the reproductive system could be carried out using a reproductive system related antigen or soluble form of a reproductive system related antigen, a reproductive system related antigen ligand, gene therapy, or ex vivo applications. Moreover, inhibitors of a reproductive system related antigen, either blocking antibodies or mutant forms, could modulate the expression of the reproductive system related antigen. These inhibitors may be useful to treat, diagnose, detect, and/or prevent diseases associated with the misregulation of a reproductive system related antigen.

[0518] In one embodiment, the invention provides a method for the specific delivery of compositions of the invention to cells (e.g., normal or diseased reproductive system cells) by administering polypeptides of the invention (e.g., reproductive system related antigen polypeptides or anti-reproductive system related antigen antibodies) that are associated with heterologous polypeptides or nucleic acids. In one example, the invention provides a method for delivering a therapeutic protein into the targeted cell (e.g., an aberrant reproductive system cell or reproductive system cancer cell). In another example, the invention provides a method for delivering a single stranded nucleic acid (e.g., antisense or ribozymes) or double stranded nucleic acid (e.g., DNA that can integrate into the cell's genome or replicate episomally and that can be transcribed) into the targeted cell.

[0519] In another embodiment, the invention provides a method for the specific destruction of cells (e.g., the destruction of aberrant reproductive system cells, including, but not limited to, reproductive system tumor cells) by administering polypeptides of the invention (e.g., reproductive system related antigen polypeptides or fragments thereof, or anti-reproductive system related antigen antibodies) in association with toxins or cytotoxic prodrugs.

[0520] By “toxin” is meant compounds that bind and activate endogenous cytotoxic effector systems, radioisotopes, holotoxins, modified toxins, catalytic subunits of toxins, cytotoxins (cytotoxic agents), or any molecules or enzymes not normally present in or on the surface of a cell that under defined conditions cause the cell's death. Toxins that may be used according to the methods of the invention include, but are not limited to, radioisotopes known in the art, compounds such as, for example, antibodies (or complement fixing containing portions thereof) that bind an inherent or induced endogenous cytotoxic effector system, thymidine kinase, endonuclease, RNAse, alpha toxin, ricin, abrin, Pseudomonas exotoxin A, diphtheria toxin, saporin, momordin, gelonin, pokeweed antiviral protein, alpha-sarcin and cholera toxin. “Toxin” also includes a cytostatic or cytocidal agent, a therapeutic agent or a radioactive metal ion, e.g., alpha-emitters such as, for example, ²¹³Bi, or other radioisotopes such as, for example, ¹⁰³Pd, ¹³³Xe, ¹³¹I, ⁶⁸Ge, ⁵⁷Co, ⁶⁵Zn, ⁸⁵Sr ³²P, ³⁵S, ⁹⁰Y, ¹⁵³Sm, ¹⁵³Gd, ¹⁶⁹Yb, ⁵¹Cr, ⁵⁴Mn, ⁷⁵Se, ¹¹³Sn, ⁹⁰Yttrium, ¹¹⁷Tin, ¹⁸⁶Rhenium, ¹⁶⁶Hololmium, and ¹⁸⁸Rhenium; luminescent labels, such as luminol; and fluorescent labels, such as fluorescein and rhodamine, and biotin.

[0521] Techniques known in the art may be applied to label antibodies of the invention. Such techniques include, but are not limited to, the use of bifunctional conjugating agents (see e.g., U.S. Pat. Nos. 5,756,065; 5,714,631; 5,696,239; 5,652,361; 5,505,931; 5,489,425; 5,435,990; 5,428,139; 5,342,604; 5,274,119; 4,994,560; and 5,808,003; the contents of each of which are hereby incorporated by reference in its entirety). A cytotoxin or cytotoxic agent includes any agent that is detrimental to cells. Examples include paclitaxol, cytochalasin B, gramicidin D, ethidium bromide, emetine, mitomycin, etoposide, tenoposide, vincristine, vinblastine, colchicin, doxorubicin, daunorubicin, dihydroxy anthracin dione, mitoxantrone, mithramycin, actinomycin D, 1-dehydrotestosterone, glucocorticoids, procaine, tetracaine, lidocaine, propranolol, and puromycin and analogs or homologs thereof. Therapeutic agents include, but are not limited to, antimetabolites (e.g., methotrexate, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-fluorouracil decarbazine), alkylating agents (e.g., mechlorethamine, thioepa chlorambucil, melphalan, carmustine (BSNU) and lomustine (CCNU), cyclothosphamide, busulfan, dibromomannitol, streptozotocin, mitomycin C, and cis-dichlorodiamine platinum (II) (DDP) cisplatin), anthracyclines (e.g., daunorubicin (formerly daunomycin) and doxorubicin), antibiotics (e.g., dactinomycin (formerly actinomycin), bleomycin, mithramycin, and anthramycin (AMC)), and anti-mitotic agents (e.g., vincristine and vinblastine).

[0522] By “cytotoxic prodrug” is meant a non-toxic compound that is converted by an enzyme, normally present in the cell, into a cytotoxic compound. Cytotoxic prodrugs that may be used according to the methods of the invention include, but are not limited to, glutamyl derivatives of benzoic acid mustard alkylating agent, phosphate derivatives of etoposide or mitomycin C, cytosine arabinoside, daunorubisin, and phenoxyacetamide derivatives of doxorubicin.

[0523] It will be appreciated that conditions caused by a decrease in the standard or normal level of a reproductive system related antigen activity in an individual, particularly disorders of the reproductive system, can be treated by administration of a reproductive system related antigen polypeptide (e.g., such as, for example, the complete reproductive system related antigen polypeptide, the soluble form of the extracellular domain of a reproductive system related antigen polypeptide, or cells expressing the complete protein) or agonist. Thus, the invention also provides a method of treatment of an individual in need of an increased level of reproductive system related antigen activity comprising administering to such an individual a pharmaceutical composition comprising an amount of an isolated reproductive system related antigen polypeptide of the invention, or agonist thereof (e.g., an agonistic anti-reproductive system related antigen antibody), effective to increase the reproductive system related antigen activity level in such an individual.

[0524] It will also be appreciated that conditions caused by a increase in the standard or normal level of reproductive system related antigen activity in an individual, particularly disorders of the reproductive system, can be treated by administration of reproductive system related antigen polypeptides (e.g., such as, for example, the complete reproductive system related antigen polypeptide, the soluble form of the extracellular domain of a reproductive system related antigen polypeptide, or cells expressing the complete protein) or antagonist (e.g., an antagonistic reproductive system related antigen antibody). Thus, the invention also provides a method of treatment of an individual in need of an decreased level of reproductive system related antigen activity comprising administering to such an individual a pharmaceutical composition comprising an amount of an isolated reproductive system related antigen polypeptide of the invention, or antagonist thereof (e.g., an antagonistic anti-reproductive system related antigen antibody), effective to decrease the reproductive system related antigen activity level in such an individual.

[0525] In certain embodiments, a polypeptide of the invention, or polynucleotides, antibodies, agonists, or antagonists corresponding to that polypeptide, may be used to diagnose and/or prognose diseases and/or disorders associated with the tissue(s) in which the polypeptide of the invention is expressed, including one, two, three, four, five, or more tissues disclosed in Table 1A, column 7 (Tissue Distribution Library Code).

[0526] More generally, polynucleotides, translation products and antibodies corresponding to this gene may be useful for the diagnosis, prognosis, prevention, and/or treatment of diseases and/or disorders associated with the following systems.

[0527] Reproductive System Disorders

[0528] The polynucleotides or polypeptides, or agonists or antagonists of the invention may be used for the diagnosis, treatment, or prevention of diseases and/or disorders of the reproductive system. Reproductive system disorders that can be treated by the compositions of the invention, include, but are not limited to, reproductive system injuries, infections, neoplastic disorders, congenital defects, and diseases or disorders which result in infertility, complications with pregnancy, labor, or parturition, and postpartum difficulties.

[0529] Reproductive system disorders and/or diseases include diseases and/or disorders of the testes, including, but not limited to, testicular atrophy, testicular feminization, cryptorchism (unilateral and bilateral), anorchia, ectopic testis, epididymitis and orchitis (typically resulting from infections such as, for example, gonorrhea, mumps, tuberculosis, and syphilis), testicular torsion, vasitis nodosa, germ cell tumors (e.g., seminomas, embryonal cell carcinomas, teratocarcinomas, choriocarcinomas, yolk sac tumors, and teratomas), stromal tumors (e.g., Leydig cell tumors), hydrocele, hematocele, varicocele, spermatocele, inguinal hernia, and disorders of sperm production (e.g., immotile cilia syndrome, aspermia, asthenozoospermia, azoospermia, oligospermia, and teratozoospermia).

[0530] Reproductive system disorders also include, but are not limited to, disorders of the prostate gland, such as acute non-bacterial prostatitis, chronic non-bacterial prostatitis, acute bacterial prostatitis, chronic bacterial prostatitis, prostatodystonia, prostatosis, granulomatous prostatitis, malacoplakia, benign prostatic hypertrophy or hyperplasia, and prostate neoplastic disorders, including adenocarcinomas, transitional cell carcinomas, ductal carcinomas, and squamous cell carcinomas.

[0531] Additionally, the compositions of the invention may be useful in the diagnosis, treatment, and/or prevention of disorders or diseases of the penis and urethra, including, but not limited to, inflammatory disorders, such as balanoposthitis, balanitis xerotica obliterans, phimosis, paraphimosis, syphilis, herpes simplex virus, gonorrhea, non-gonococcal urethritis, chlamydia, mycoplasma, trichomonas, HIV, AIDS, Reiter's syndrome, condyloma acuminatum, condyloma latum, and pearly penile papules; urethral abnormalities, such as hypospadias, epispadias, and phimosis; premalignant lesions, including Erythroplasia of Queyrat, Bowen's disease, Bowenoid paplosis, giant condyloma of Buscke-Lowenstein, and varrucous carcinoma; penile cancers, including squamous cell carcinomas, carcinoma in situ, verrucous carcinoma, and disseminated penile carcinoma; urethral neoplastic disorders, including penile urethral carcinoma, bulbomembranous urethral carcinoma, and prostatic urethral carcinoma; and erectile disorders, such as priapism, Peyronie's disease, erectile dysfunction, and impotence.

[0532] Moreover, diseases and/or disorders of the vas deferens include, but are not limited to, vasculititis and CBAVD (congenital bilateral absence of the vas deferens); additionally, the polynucleotides, polypeptides, and agonists or antagonists of the present invention may be used in the diagnosis, treatment, and/or prevention of diseases and/or disorders of the seminal vesicles, including but not limited to, hydatid disease, congenital chloride diarrhea, and polycystic kidney disease.

[0533] Other disorders and/or diseases of the male reproductive system that may be diagnosed, treated, and/or prevented with the compositions of the invention include, but are not limited to, Klinefelter's syndrome, Young's syndrome, premature ejaculation, diabetes mellitus, cystic fibrosis, Kartagener's syndrome, high fever, multiple sclerosis, and gynecomastia.

[0534] Further, the polynucleotides, polypeptides, and agonists or antagonists of the present invention may be used in the diagnosis, treatment, and/or prevention of diseases and/or disorders of the vagina and vulva, including, but not limited to, bacterial vaginosis, candida vaginitis, herpes simplex virus, chancroid, granuloma inguinale, lymphogranuloma venereum, scabies, human papillomavirus, vaginal trauma, vulvar trauma, adenosis, chlamydia vaginitis, gonorrhea, trichomonas vaginitis, condyloma acuminatum, syphilis, molluscum contagiosum, atrophic vaginitis, Paget's disease, lichen sclerosus, lichen planus, vulvodynia, toxic shock syndrome, vaginismus, vulvovaginitis, vulvar vestibulitis, and neoplastic disorders, such as squamous cell hyperplasia, clear cell carcinoma, basal cell carcinoma, melanomas, cancer of Bartholin's gland, and vulvar intraepithelial neoplasia.

[0535] Disorders and/or diseases of the uterus that may be diagnosed, treated, and/or prevented with the compositions of the invention include, but are not limited to, dysmenorrhea, retroverted uterus, endometriosis, fibroids, adenomyosis, anovulatory bleeding, amenorrhea, Cushing's syndrome, hydatidiform moles, Asherman's syndrome, premature menopause, precocious puberty, uterine polyps, dysfunctional uterine bleeding (e.g., due to aberrant hormonal signals), and neoplastic disorders, such as adenocarcinomas, keiomyosarcomas, and sarcomas. Additionally, the polypeptides, polynucleotides, or agonists or antagonists of the invention may be useful as a marker or detector of, as well as in the diagnosis, treatment, and/or prevention of congenital uterine abnormalities, such as bicornuate uterus, septate uterus, simple unicornuate uterus, unicornuate uterus with a noncavitary rudimentary horn, unicornuate uterus with a non-communicating cavitary rudimentary horn, unicornuate uterus with a communicating cavitary horn, arcuate uterus, uterine didelfus, and T-shaped uterus.

[0536] Ovarian diseases and/or disorders that may be diagnosed, treated, and/or prevented with the compositions of the invention include, but are not limited to, anovulation, polycystic ovary syndrome (Stein-Leventhal syndrome), ovarian cysts, ovarian hypofunction, ovarian insensitivity to gonadotropins, ovarian overproduction of androgens, right ovarian vein syndrome, amenorrhea, hirutism, and ovarian cancer (including, but not limited to, primary and secondary cancerous growth, Sertoli-Leydig tumors, endometriod carcinoma of the ovary, ovarian papillary serous adenocarcinoma, ovarian mucinous adenocarcinoma, and Ovarian Krukenberg tumors).

[0537] Cervical diseases and/or disorders that may be diagnosed, treated, and/or prevented with the compositions of the invention include, but are not limited to, cervicitis, chronic cervicitis, mucopurulent cervicitis, cervical dysplasia, cervical polyps, Nabothian cysts, cervical erosion, cervical incompetence, and cervical neoplasms (including, for example, cervical carcinoma, squamous metaplasia, squamous cell carcinoma, adenosquamous cell neoplasia, and columnar cell neoplasia).

[0538] Additionally, diseases and/or disorders of the reproductive system that may be diagnosed, treated, and/or prevented with the compositions of the invention include, but are not limited to, disorders and/or diseases of pregnancy, including miscarriage and stillbirth, such as early abortion, late abortion, spontaneous abortion, induced abortion, therapeutic abortion, threatened abortion, missed abortion, incomplete abortion, complete abortion, habitual abortion, missed abortion, and septic abortion; ectopic pregnancy, anemia, Rh incompatibility, vaginal bleeding during pregnancy, gestational diabetes, intrauterine growth retardation, polyhydramnios, HELLP syndrome, abruptio placentae, placenta previa, hyperemesis, preeclampsia, eclampsia, herpes gestationis, and urticaria of pregnancy. Additionally, the polynucleotides, polypeptides, and agonists or antagonists of the present invention may be used in the diagnosis, treatment, and/or prevention of diseases that can complicate pregnancy, including heart disease, heart failure, rheumatic heart disease, congenital heart disease, mitral valve prolapse, high blood pressure, anemia, kidney disease, infectious disease (e.g., rubella, cytomegalovirus, toxoplasmosis, infectious hepatitis, chlamydia, HIV, AIDS, and genital herpes), diabetes mellitus, Graves' disease, thyroiditis, hypothyroidism, Hashimoto's thyroiditis, chronic active hepatitis, cirrhosis of the liver, primary biliary cirrhosis, asthma, systemic lupus eryematosis, rheumatoid arthritis, myasthenia gravis, idiopathic thrombocytopenic purpura, appendicitis, ovarian cysts, gallbladder disorders,and obstruction of the intestine.

[0539] Complications associated with labor and parturition that may be diagnosed, treated, and/or prevented with the compositions of the invention include, but are not limited to, premature rupture of the membranes, pre-term labor, post-term pregnancy, postmaturity, labor that progresses too slowly, fetal distress (e.g., abnormal heart rate (fetal or maternal), breathing problems, and abnormal fetal position), shoulder dystocia, prolapsed umbilical cord, amniotic fluid embolism, and aberrant uterine bleeding.

[0540] Further, diseases and/or disorders of the postdelivery period, that may be diagnosed, treated, and/or prevented with the compositions of the invention, include, but are not limited to, endometritis, myometritis, parametritis, peritonitis, pelvic thrombophlebitis, pulmonary embolism, endotoxemia, pyelonephritis, saphenous thrombophlebitis, mastitis, cystitis, postpartum hemorrhage, and inverted uterus.

[0541] Other disorders and/or diseases of the female reproductive system that may be diagnosed, treated, and/or prevented by the polynucleotides, polypeptides, and agonists or antagonists of the present invention include, but are not limited to, Turner's syndrome, pseudohermaphroditism, premenstrual syndrome, pelvic inflammatory disease, pelvic congestion (vascular engorgement), frigidity, anorgasmia, dyspareunia, ruptured fallopian tube, and Mittelschmerz.

[0542] Immune Activity

[0543] Polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in treating, preventing, diagnosing and/or prognosing diseases, disorders, and/or conditions of the immune system, by, for example, activating or inhibiting the proliferation, differentiation, or mobilization (chemotaxis) of immune cells. Immune cells develop through a process called hematopoiesis, producing myeloid (platelets, red blood cells, neutrophils, and macrophages) and lymphoid (B and T lymphocytes) cells from pluripotent stem cells. The etiology of these immune diseases, disorders, and/or conditions may be genetic, somatic, such as cancer and some autoimmune diseases, acquired (e.g., by chemotherapy or toxins), or infectious. Moreover, polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention can be used as a marker or detector of a particular immune system disease or disorder.

[0544] In another embodiment, a polypeptide of the invention, or polynucleotides, antibodies, agonists, or antagonists corresponding to that polypeptide, may be used to treat diseases and disorders of the immune system and/or to inhibit or enhance an immune response generated by cells associated with the tissue(s) in which the polypeptide of the invention is expressed, including one, two, three, four, five, or more tissues disclosed in Table 1A, column 7 (Tissue Distribution Library Code).

[0545] Polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in treating, preventing, diagnosing, and/or prognosing immunodeficiencies, including both congenital and acquired immunodeficiencies. Examples of B cell immunodeficiencies in which immunoglobulin levels B cell function and/or B cell numbers are decreased include: X-linked agammaglobulinemia (Bruton's disease), X-linked infantile agammaglobulinemia, X-linked immunodeficiency with hyper IgM, non X-linked immunodeficiency with hyper IgM, X-linked lymphoproliferative syndrome (XLP), agammaglobulinemia including congenital and acquired agammaglobulinemia, adult onset agammaglobulinemia, late-onset agammaglobulinemia, dysgammaglobulinemia, hypogammaglobulinemia, unspecified hypogammaglobulinemia, recessive agammaglobulinemia (Swiss type), Selective IgM deficiency, selective IgA deficiency, selective IgG subclass deficiencies, IgG subclass deficiency (with or without IgA deficiency), Ig deficiency with increased IgM, IgG and IgA deficiency with increased IgM, antibody deficiency with normal or elevated Igs, Ig heavy chain deletions, kappa chain deficiency, B cell lymphoproliferative disorder (BLPD), common variable immunodeficiency (CVID), common variable immunodeficiency (CVI) (acquired), and transient hypogammaglobulinemia of infancy.

[0546] In specific embodiments, ataxia-telangiectasia or conditions associated with ataxia-telangiectasia are treated, prevented, diagnosed, and/or prognosing using the polypeptides or polynucleotides of the invention, and/or agonists or antagonists thereof.

[0547] Examples of congenital immunodeficiencies in which T cell and/or B cell function and/or number is decreased include, but are not limited to: DiGeorge anomaly, severe combined immunodeficiencies (SCID) (including, but not limited to, X-linked SCID, autosomal recessive SCID, adenosine deaminase deficiency, purine nucleoside phosphorylase (PNP) deficiency, Class II MHC deficiency (Bare lymphocyte syndrome), Wiskott-Aldrich syndrome, and ataxia telangiectasia), thymic hypoplasia, third and fourth pharyngeal pouch syndrome, 22q11.2 deletion, chronic mucocutaneous candidiasis, natural killer cell deficiency (NK), idiopathic CD4+T-lymphocytopenia, immunodeficiency with predominant T cell defect (unspecified), and unspecified immunodeficiency of cell mediated immunity.

[0548] In specific embodiments, DiGeorge anomaly or conditions associated with DiGeorge anomaly are treated, prevented, diagnosed, and/or prognosed using polypeptides or polynucleotides of the invention, or antagonists or agonists thereof.

[0549] Other immunodeficiencies that may be treated, prevented, diagnosed, and/or prognosed using polypeptides or polynucleotides of the invention, and/or agonists or antagonists thereof, include, but are not limited to, chronic granulomatous disease, Chédiak-Higashi syndrome, myeloperoxidase deficiency, leukocyte glucose-6-phosphate dehydrogenase deficiency, X-linked lymphoproliferative syndrome (XLP), leukocyte adhesion deficiency, complement component deficiencies (including C1, C2, C3, C4, C5, C6, C7, C8 and/or C9 deficiencies), reticular dysgenesis, thymic alymphoplasia-aplasia, immunodeficiency with thymoma, severe congenital leukopenia, dysplasia with immunodeficiency, neonatal neutropenia, short limbed dwarfism, and Nezelof syndrome-combined immunodeficiency with Igs.

[0550] In a preferred embodiment, the immunodeficiencies and/or conditions associated with the immunodeficiencies recited above are treated, prevented, diagnosed and/or prognosed using polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention.

[0551] In a preferred embodiment polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention could be used as an agent to boost immunoresponsiveness among immunodeficient individuals. In specific embodiments, polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention could be used as an agent to boost immunoresponsiveness among B cell and/or T cell immunodeficient individuals.

[0552] The polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in treating, preventing, diagnosing and/or prognosing autoimmune disorders. Many autoimmune disorders result from inappropriate recognition of self as foreign material by immune cells. This inappropriate recognition results in an immune response leading to the destruction of the host tissue. Therefore, the administration of polynucleotides and polypeptides of the invention that can inhibit an immune response, particularly the proliferation, differentiation, or chemotaxis of T-cells, may be an effective therapy in preventing autoimmune disorders.

[0553] Autoimmune diseases or disorders that may be treated, prevented, diagnosed and/or prognosed by polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention include, but are not limited to, one or more of the following: systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, autoimmune thyroiditis, Hashimoto's thyroiditis, autoimmune hemolytic anemia, hemolytic anemia, thrombocytopenia, autoimmune thrombocytopenia purpura, autoimmune neonatal thrombocytopenia, idiopathic thrombocytopenia purpura, purpura (e.g., Henloch-Scoenlein purpura), autoimmunocytopenia, Goodpasture's syndrome, Pemphigus vulgaris, myasthenia gravis, Grave's disease (hyperthyroidism), and insulin-resistant diabetes mellitus.

[0554] Additional disorders that are likely to have an autoimmune component that may be treated, prevented, and/or diagnosed with the compositions of the invention include, but are not limited to, type II collagen-induced arthritis, antiphospholipid syndrome, dermatitis, allergic encephalomyelitis, myocarditis, relapsing polychondritis, rheumatic heart disease, neuritis, uveitis ophthalmia, polyendocrinopathies, Reiter's Disease, Stiff-Man Syndrome, autoimmune pulmonary inflammation, autism, Guillain-Barre Syndrome, insulin dependent diabetes mellitus, and autoimmune inflammatory eye disorders.

[0555] Additional disorders that are likely to have an autoimmune component that may be treated, prevented, diagnosed and/or prognosed with the compositions of the invention include, but are not limited to, scleroderma with anti-collagen antibodies (often characterized, e.g., by nucleolar and other nuclear antibodies), mixed connective tissue disease (often characterized, e.g., by antibodies to extractable nuclear antigens (e.g., ribonucleoprotein)), polymyositis (often characterized, e.g., by nonhistone ANA), pernicious anemia (often characterized, e.g., by antiparietal cell, microsomes, and intrinsic factor antibodies), idiopathic Addison's disease (often characterized, e.g., by humoral and cell-mediated adrenal cytotoxicity, infertility (often characterized, e.g., by antispermatozoal antibodies), glomerulonephritis (often characterized, e.g., by glomerular basement membrane antibodies or immune complexes), bullous pemphigoid (often characterized, e.g., by IgG and complement in basement membrane), Sjogren's syndrome (often characterized, e.g., by multiple tissue antibodies, and/or a specific nonhistone ANA (SS-B)), diabetes mellitus (often characterized, e.g., by cell-mediated and humoral islet cell antibodies), and adrenergic drug resistance (including adrenergic drug resistance with asthma or cystic fibrosis) (often characterized, e.g., by beta-adrenergic receptor antibodies).

[0556] Additional disorders that may have an autoimmune component that may be treated, prevented, diagnosed and/or prognosed with the compositions of the invention include, but are not limited to, chronic active hepatitis (often characterized, e.g., by smooth muscle antibodies), primary biliary cirrhosis (often characterized, e.g., by mitochondria antibodies), other endocrine gland failure (often characterized, e.g., by specific tissue antibodies in some cases), vitiligo (often characterized, e.g., by melanocyte antibodies), vasculitis (often characterized, e.g., by Ig and complement in vessel walls and/or low serum complement), post-MI (often characterized, e.g., by myocardial antibodies), cardiotomy syndrome (often characterized, e.g., by myocardial antibodies), urticaria (often characterized, e.g., by IgG and IgM antibodies to IgE), atopic dermatitis (often characterized, e.g., by IgG and IgM antibodies to IgE), asthma (often characterized, e.g., by IgG and IgM antibodies to IgE), and many other inflammatory, granulomatous, degenerative, and atrophic disorders.

[0557] In a preferred embodiment, the autoimmune diseases and disorders and/or conditions associated with the diseases and disorders recited above are treated, prevented, diagnosed and/or prognosed using for example, antagonists or agonists, polypeptides or polynucleotides, or antibodies of the present invention. In a specific preferred embodiment, rheumatoid arthritis is treated, prevented, and/or diagnosed using polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention.

[0558] In another specific preferred embodiment, systemic lupus erythematosus is treated, prevented, and/or diagnosed using polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention. In another specific preferred embodiment, idiopathic thrombocytopenia purpura is treated, prevented, and/or diagnosed using polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention.

[0559] In another specific preferred embodiment IgA nephropathy is treated, prevented, and/or diagnosed using polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention.

[0560] In a preferred embodiment, the autoimmune diseases and disorders and/or conditions associated with the diseases and disorders recited above are treated, prevented, diagnosed and/or prognosed using polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention.

[0561] In preferred embodiments, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a immunosuppressive agent(s).

[0562] Polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in treating, preventing, prognosing, and/or diagnosing diseases, disorders, and/or conditions of hematopoietic cells. Polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention could be used to increase differentiation and proliferation of hematopoietic cells, including the pluripotent stem cells, in an effort to treat or prevent those diseases, disorders, and/or conditions associated with a decrease in certain (or many) types hematopoietic cells, including but not limited to, leukopenia, neutropenia, anemia, and thrombocytopenia. Alternatively, Polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention could be used to increase differentiation and proliferation of hematopoietic cells, including the pluripotent stem cells, in an effort to treat or prevent those diseases, disorders, and/or conditions associated with an increase in certain (or many) types of hematopoietic cells, including but not limited to, histiocytosis.

[0563] Allergic reactions and conditions, such as asthma (particularly allergic asthma) or other respiratory problems, may also be treated, prevented, diagnosed and/or prognosed using polypeptides, antibodies, or polynucleotides of the invention, and/or agonists or antagonists thereof. Moreover, these molecules can be used to treat, prevent, prognose, and/or diagnose anaphylaxis, hypersensitivity to an antigenic molecule, or blood group incompatibility.

[0564] Additionally, polypeptides or polynucleotides of the invention, and/or agonists or antagonists thereof, may be used to treat, prevent, diagnose and/or prognose IgE-mediated allergic reactions. Such allergic reactions include, but are not limited to, asthma, rhinitis, and eczema. In specific embodiments, polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be used to modulate IgE concentrations in vitro or in vivo.

[0565] Moreover, polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention have uses in the diagnosis, prognosis, prevention, and/or treatment of inflammatory conditions. For example, since polypeptides, antibodies, or polynucleotides of the invention, and/or agonists or antagonists of the invention may inhibit the activation, proliferation and/or differentiation of cells involved in an inflammatory response, these molecules can be used to prevent and/or treat chronic and acute inflammatory conditions. Such inflammatory conditions include, but are not limited to, for example, inflammation associated with infection (e.g., septic shock, sepsis, or systemic inflammatory response syndrome), ischemia-reperfusion injury, endotoxin lethality, complement-mediated hyperacute rejection, nephritis, cytokine or chemokine induced lung injury, inflammatory bowel disease, Crohn's disease, over production of cytokines (e.g., TNF or IL-1.), respiratory disorders (e.g., asthma and allergy); gastrointestinal disorders (e.g., inflammatory bowel disease); cancers (e.g., gastric, ovarian, lung, bladder, liver, and breast); CNS disorders (e.g., multiple sclerosis; ischemic brain injury and/or stroke, traumatic brain injury, neurodegenerative disorders (e.g., Parkinson's disease and Alzheimer's disease); AIDS-related dementia; and prion disease); cardiovascular disorders (e.g., atherosclerosis, myocarditis, cardiovascular disease, and cardiopulmonary bypass complications); as well as many additional diseases, conditions, and disorders that are characterized by inflammation (e.g., hepatitis, rheumatoid arthritis, gout, trauma, pancreatitis, sarcoidosis, dermatitis, renal ischemia-reperfusion injury, Grave's disease, systemic lupus erythematosus, diabetes mellitus, and allogenic transplant rejection).

[0566] Because inflammation is a fundamental defense mechanism, inflammatory disorders can effect virtually any tissue of the body. Accordingly, polynucleotides, polypeptides, and antibodies of the invention, as well as agonists or antagonists thereof, have uses in the treatment of tissue-specific inflammatory disorders, including, but not limited to, adrenalitis, alveolitis, angiocholecystitis, appendicitis, balanitis, blepharitis, bronchitis, bursitis, carditis, cellulitis, cervicitis, cholecystitis, chorditis, cochlitis, colitis, conjunctivitis, cystitis, dermatitis, diverticulitis, encephalitis, endocarditis, esophagitis, eustachitis, fibrositis, folliculitis, gastritis, gastroenteritis, gingivitis, glossitis, hepatosplenitis, keratitis, labyrinthitis, laryngitis, lymphangitis, mastitis, media otitis, meningitis, metritis, mucitis, myocarditis, myosititis, myringitis, nephritis, neuritis, orchitis, osteochondritis, otitis, pericarditis, peritendonitis, peritonitis, pharyngitis, phlebitis, poliomyelitis, prostatitis, pulpitis, retinitis, rhinitis, salpingitis, scleritis, sclerochoroiditis, scrotitis, sinusitis, spondylitis, steatitis, stomatitis, synovitis, syringitis, tendonitis, tonsillitis, urethritis, and vaginitis.

[0567] In specific embodiments, polypeptides, antibodies, or polynucleotides of the invention, and/or agonists or antagonists thereof, are useful to diagnose, prognose, prevent, and/or treat organ transplant rejections and graft-versus-host disease. Organ rejection occurs by host immune cell destruction of the transplanted tissue through an immune response. Similarly, an immune response is also involved in GVHD, but, in this case, the foreign transplanted immune cells destroy the host tissues. Polypeptides, antibodies, or polynucleotides of the invention, and/or agonists or antagonists thereof, that inhibit an immune response, particularly the activation, proliferation, differentiation, or chemotaxis of T-cells, may be an effective therapy in preventing organ rejection or GVHD. In specific embodiments, polypeptides, antibodies, or polynucleotides of the invention, and/or agonists or antagonists thereof, that inhibit an immune response, particularly the activation, proliferation, differentiation, or chemotaxis of T-cells, may be an effective therapy in preventing experimental allergic and hyperacute xenograft rejection.

[0568] In other embodiments, polypeptides, antibodies, or polynucleotides of the invention, and/or agonists or antagonists thereof, are useful to diagnose, prognose, prevent, and/or treat immune complex diseases, including, but not limited to, serum sickness, post streptococcal glomerulonephritis, polyarteritis nodosa, and immune complex-induced vasculitis.

[0569] Polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the invention can be used to treat, detect, and/or prevent infectious agents. For example, by increasing the immune response, particularly increasing the proliferation activation and/or differentiation of B and/or T cells, infectious diseases may be treated, detected, and/or prevented. The immune response may be increased by either enhancing an existing immune response, or by initiating a new immune response. Alternatively, polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may also directly inhibit the infectious agent (refer to section of application listing infectious agents, etc), without necessarily eliciting an immune response.

[0570] In another embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a vaccine adjuvant that enhances immune responsiveness to an antigen. In a specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an adjuvant to enhance tumor-specific immune responses.

[0571] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an adjuvant to enhance anti-viral immune responses. Anti-viral immune responses that may be enhanced using the compositions of the invention as an adjuvant, include virus and virus associated diseases or symptoms described herein or otherwise known in the art. In specific embodiments, the compositions of the invention are used as an adjuvant to enhance an immune response to a virus, disease, or symptom selected from the group consisting of: AIDS, meningitis, Dengue, EBV, and hepatitis (e.g., hepatitis B). In another specific embodiment, the compositions of the invention are used as an adjuvant to enhance an immune response to a virus, disease, or symptom selected from the group consisting of: HIV/AIDS, respiratory syncytial virus, Dengue, rotavirus, Japanese B encephalitis, influenza A and B, parainfluenza, measles, cytomegalovirus, rabies, Junin, Chikungunya, Rift Valley Fever, herpes simplex, and yellow fever.

[0572] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an adjuvant to enhance anti-bacterial or anti-fungal immune responses. Anti-bacterial or anti-fungal immune responses that may be enhanced using the compositions of the invention as an adjuvant, include bacteria or fungus and bacteria or fungus associated diseases or symptoms described herein or otherwise known in the art. In specific embodiments, the compositions of the invention are used as an adjuvant to enhance an immune response to a bacteria or fungus, disease, or symptom selected from the group consisting of: tetanus, Diphtheria, botulism, and meningitis type B.

[0573] In another specific embodiment, the compositions of the invention are used as an adjuvant to enhance an immune response to a bacteria or fungus, disease, or symptom selected from the group consisting of: Vibrio cholerae, Mycobacterium leprae, Salmonella typhi, Salmonella paratyphi, Meisseria men ingitidis, Streptococcus pneumoniae, Group B streptococcus, Shigella spp., Enterotoxigenic Escherichia coli, Enterohemorrhagic E. coli, and Borrelia burgdorferi.

[0574] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an adjuvant to enhance anti-parasitic immune responses. Anti-parasitic immune responses that may be enhanced using the compositions of the invention as an adjuvant, include parasite and parasite associated diseases or symptoms described herein or otherwise known in the art. In specific embodiments, the compositions of the invention are used as an adjuvant to enhance an immune response to a parasite. In another specific embodiment, the compositions of the invention are used as an adjuvant to enhance an immune response to Plasmodium (malaria) or Leishmania.

[0575] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention may also be employed to treat infectious diseases including silicosis, sarcoidosis, and idiopathic pulmonary fibrosis; for example, by preventing the recruitment and activation of mononuclear phagocytes.

[0576] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an antigen for the generation of antibodies to inhibit or enhance immune mediated responses against polypeptides of the invention.

[0577] In one embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are administered to an animal (e.g., mouse, rat, rabbit, hamster, guinea pig, pigs, micro-pig, chicken, camel, goat, horse, cow, sheep, dog, cat, non-human primate, and human, most preferably human) to boost the immune system to produce increased quantities of one or more antibodies (e.g., IgG, IgA, IgM, and IgE), to induce higher affinity antibody production and immunoglobulin class switching (e.g., IgG, IgA, IgM, and IgE), and/or to increase an immune response.

[0578] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a stimulator of B cell responsiveness to pathogens.

[0579] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an activator of T cells.

[0580] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an agent that elevates the immune status of an individual prior to their receipt of immunosuppressive therapies.

[0581] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an agent to induce higher affinity antibodies.

[0582] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an agent to increase serum immunoglobulin concentrations.

[0583] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an agent to accelerate recovery of immunocompromised individuals.

[0584] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an agent to boost immunoresponsiveness among aged populations and/or neonates.

[0585] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an immune system enhancer prior to, during, or after bone marrow transplant and/or other transplants (e.g., allogeneic or xenogeneic organ transplantation). With respect to transplantation, compositions of the invention may be administered prior to, concomitant with, and/or after transplantation. In a specific embodiment, compositions of the invention are administered after transplantation, prior to the beginning of recovery of T-cell populations. In another specific embodiment, compositions of the invention are first administered after transplantation after the beginning of recovery of T cell populations, but prior to full recovery of B cell populations.

[0586] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an agent to boost immunoresponsiveness among individuals having an acquired loss of B cell function. Conditions resulting in an acquired loss of B cell function that may be ameliorated or treated by administering the polypeptides, antibodies, polynucleotides and/or agonists or antagonists thereof, include, but are not limited to, HIV Infection, AIDS, bone marrow transplant, and B cell chronic lymphocytic leukemia (CLL).

[0587] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an agent to boost immunoresponsiveness among individuals having a temporary immune deficiency. Conditions resulting in a temporary immune deficiency that may be ameliorated or treated by administering the polypeptides, antibodies, polynucleotides and/or agonists or antagonists thereof, include, but are not limited to, recovery from viral infections (e.g., influenza), conditions associated with malnutrition, recovery from infectious mononucleosis, or conditions associated with stress, recovery from measles, recovery from blood transfusion, and recovery from surgery.

[0588] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a regulator of antigen presentation by monocytes, dendritic cells, and/or B-cells. In one embodiment, polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention enhance antigen presentation or antagonizes antigen presentation in vitro or in vivo. Moreover, in related embodiments, said enhancement or antagonism of antigen presentation may be useful as an anti-tumor treatment or to modulate the immune system.

[0589] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as an agent to direct an individual's immune system towards development of a humoral response (i.e. TH2) as opposed to a TH1 cellular response.

[0590] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a means to induce tumor proliferation and thus make it more susceptible to anti-neoplastic agents. For example, multiple myeloma is a slowly dividing disease and is thus refractory to virtually all anti-neoplastic regimens. If these cells were forced to proliferate more rapidly their susceptibility profile would likely change.

[0591] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a stimulator of B cell production in pathologies such as AFDS, chronic lymphocyte disorder and/or Common Variable Immunodificiency.

[0592] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a therapy for generation and/or regeneration of lymphoid tissues following surgery, trauma or genetic defect. In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used in the pretreatment of bone marrow samples prior to transplant.

[0593] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a gene-based therapy for genetically inherited disorders resulting in immuno-incompetence/immunodeficiency such as observed among SCID patients.

[0594] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a means of activating monocytes/macrophages to defend against parasitic diseases that effect monocytes such as Leishmania.

[0595] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a means of regulating secreted cytokines that are elicited by polypeptides of the invention.

[0596] In another embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used in one or more of the applications decribed herein, as they may apply to veterinary medicine.

[0597] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a means of blocking various aspects of immune responses to foreign agents or self. Examples of diseases or conditions in which blocking of certain aspects of immune responses may be desired include autoimmune disorders such as lupus, and arthritis, as well as immunoresponsiveness to skin allergies, inflammation, bowel disease, injury and diseases/disorders associated with pathogens.

[0598] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a therapy for preventing the B cell proliferation and Ig secretion associated with autoimmune diseases such as idiopathic thrombocytopenic purpura, systemic lupus erythematosus and multiple sclerosis.

[0599] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a inhibitor of B and/or T cell migration in endothelial cells. This activity disrupts tissue architecture or cognate responses and is useful, for example in disrupting immune responses, and blocking sepsis.

[0600] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a therapy for chronic hypergammaglobulinemia evident in such diseases as monoclonal gammopathy of undetermined significance (MGUS), Waldenstrom's disease, related idiopathic monoclonal gammopathies, and plasmacytomas.

[0601] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention may be employed for instance to inhibit polypeptide chemotaxis and activation of macrophages and their precursors, and of neutrophils, basophils, B lymphocytes and some T-cell subsets, e.g., activated and CD8 cytotoxic T cells and natural killer cells, in certain autoimmune and chronic inflammatory and infective diseases. Examples of autoimmune diseases are described herein and include multiple sclerosis, and insulin-dependent diabetes.

[0602] The polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention may also be employed to treat idiopathic hyper-eosinophilic syndrome by, for example, preventing eosinophil production and migration.

[0603] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used to enhance or inhibit complement mediated cell lysis.

[0604] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used to enhance or inhibit antibody dependent cellular cytotoxicity.

[0605] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention may also be employed for treating atherosclerosis, for example, by preventing monocyte infiltration in the artery wall.

[0606] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention may be employed to treat adult respiratory distress syndrome (ARDS).

[0607] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention may be useful for stimulating wound and tissue repair, stimulating angiogenesis, and/or stimulating the repair of vascular or lymphatic diseases or disorders. Additionally, agonists and antagonists of the invention may be used to stimulate the regeneration of mucosal surfaces.

[0608] In a specific embodiment, polynucleotides or polypeptides, and/or agonists thereof are used to diagnose, prognose, treat, and/or prevent a disorder characterized by primary or acquired immunodeficiency, deficient serum immunoglobulin production, recurrent infections, and/or immune system dysfunction. Moreover, polynucleotides or polypeptides, and/or agonists thereof may be used to treat or prevent infections of the joints, bones, skin, and/or parotid glands, blood-borne infections (e.g., sepsis, meningitis, septic arthritis, and/or osteomyelitis), autoimmune diseases (e.g., those disclosed herein), inflammatory disorders, and malignancies, and/or any disease or disorder or condition associated with these infections, diseases, disorders and/or malignancies) including, but not limited to, CVID, other primary immune deficiencies, HIV disease, CLL, recurrent bronchitis, sinusitis, otitis media, conjunctivitis, pneumonia, hepatitis, meningitis, herpes zoster (e.g., severe herpes zoster), and/or pneumocystis carnii. Other diseases and disorders that may be prevented, diagnosed, prognosed, and/or treated with polynucleotides or polypeptides, and/or agonists of the present invention include, but are not limited to, HIV infection, HTLV-BLV infection, lymphopenia, phagocyte bactericidal dysfunction anemia, thrombocytopenia, and hemoglobinuria.

[0609] In another embodiment, polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention are used to treat, and/or diagnose an individual having common variable immunodeficiency disease (“CVID”; also known as “acquired agammaglobulinemia” and “acquired hypogammaglobulinemia”) or a subset of this disease.

[0610] In a specific embodiment, polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be used to diagnose, prognose, prevent, and/or treat cancers or neoplasms including immune cell or immune tissue-related cancers or neoplasms. Examples of cancers or neoplasms that may be prevented, diagnosed, or treated by polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention include, but are not limited to, acute myelogenous leukemia, chronic myelogenous leukemia, Hodgkin's disease, non-Hodgkin's lymphoma, acute lymphocytic anemia (ALL) Chronic lymphocyte leukemia, plasmacytomas, multiple myeloma, Burkitt's lymphoma, EBV-transformed diseases, and/or diseases and disorders described in the section entitled “Hyperproliferative Disorders” elsewhere herein.

[0611] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a therapy for decreasing cellular proliferation of Large B-cell Lymphomas.

[0612] In another specific embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are used as a means of decreasing the involvement of B cells and Ig associated with Chronic Myelogenous Leukemia.

[0613] In specific embodiments, the compositions of the invention are used as an agent to boost immunoresponsiveness among B cell immunodeficient individuals, such as, for example, an individual who has undergone a partial or complete splenectomy.

[0614] Antagonists of the invention include, for example, binding and/or inhibitory antibodies, antisense nucleic acids, ribozymes or soluble forms of the polypeptides of the present invention (e.g., Fc fusion protein; see, e.g., Example 9). Agonists of the invention include, for example, binding or stimulatory antibodies, and soluble forms of the polypeptides (e.g., Fc fusion proteins; see, e.g., Example 9). Polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention may be employed in a composition with a pharmaceutically acceptable carrier, e.g., as described herein.

[0615] In another embodiment, polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention are administered to an animal (including, but not limited to, those listed above, and also including transgenic animals) incapable of producing functional endogenous antibody molecules or having an otherwise compromised endogenous immune system, but which is capable of producing human immunoglobulin molecules by means of a reconstituted or partially reconstituted immune system from another animal (see, e.g., published PCT Application Nos. WO98/24893, WO/9634096, WO/9633735, and WO/9110741). Administration of polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention to such animals is useful for the generation of monoclonal antibodies against the polypeptides, antibodies, polynucleotides and/or agonists or antagonists of the present invention.

[0616] Blood-Related Disorders

[0617] The polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be used to modulate hemostatic (the stopping of bleeding) or thrombolytic (clot dissolving) activity. For example, by increasing hemostatic or thrombolytic activity, polynucleotides or polypeptides, and/or agonists or antagonists of the present invention could be used to treat or prevent blood coagulation diseases, disorders, and/or conditions (e.g., afibrinogenemia, factor deficiencies, hemophilia), blood platelet diseases, disorders, and/or conditions (e.g., thrombocytopenia), or wounds resulting from trauma, surgery, or other causes. Alternatively, polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention that can decrease hemostatic or thrombolytic activity could be used to inhibit or dissolve clotting. These molecules could be important in the treatment or prevention of heart attacks (infarction), strokes, or scarring.

[0618] In specific embodiments, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be used to prevent, diagnose, prognose, and/or treat thrombosis, arterial thrombosis, venous thrombosis, thromboembolism, pulmonary embolism, atherosclerosis, myocardial infarction, transient ischemic attack, unstable angina. In specific embodiments, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be used for the prevention of occulsion of saphenous grafts, for reducing the risk of periprocedural thrombosis as might accompany angioplasty procedures, for reducing the risk of stroke in patients with atrial fibrillation including nonrheumatic atrial fibrillation, for reducing the risk of embolism associated with mechanical heart valves and or mitral valves disease. Other uses for the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention, include, but are not limited to, the prevention of occlusions in extrcorporeal devices (e.g., intravascular canulas, vascular access shunts in hemodialysis patients, hemodialysis machines, and cardiopulmonary bypass machines).

[0619] In another embodiment, a polypeptide of the invention, or polynucleotides, antibodies, agonists, or antagonists corresponding to that polypeptide, may be used to prevent, diagnose, prognose, and/or treat diseases and disorders of the blood and/or blood forming organs associated with the tissue(s) in which the polypeptide of the invention is expressed, including one, two, three, four, five, or more tissues disclosed in Table 1A, column 7 (Tissue Distribution Library Code).

[0620] The polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be used to modulate hematopoietic activity (the formation of blood cells). For example, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be used to increase the quantity of all or subsets of blood cells, such as, for example, erythrocytes, lymphocytes (B or T cells), myeloid cells (e.g., basophils, eosinophils, neutrophils, mast cells, macrophages) and platelets. The ability to decrease the quantity of blood cells or subsets of blood cells may be useful in the prevention, detection, diagnosis and/or treatment of anemias and leukopenias described below. Alternatively, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be used to decrease the quantity of all or subsets of blood cells, such as, for example, erythrocytes, lymphocytes (B or T cells), myeloid cells (e.g., basophils, cosinophils, neutrophils, mast cells, macrophages) and platelets. The ability to decrease the quantity of blood cells or subsets of blood cells may be useful in the prevention, detection, diagnosis and/or treatment of leukocytoses, such as, for example eosinophilia.

[0621] The polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be used to prevent, treat, or diagnose blood dyscrasia.

[0622] Anemias are conditions in which the number of red blood cells or amount of hemoglobin (the protein that carries oxygen) in them is below normal. Anemia may be caused by excessive bleeding, decreased red blood cell production, or increased red blood cell destruction (hemolysis). The polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in treating, preventing, and/or diagnosing anemias. Anemias that may be treated prevented or diagnosed by the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention include iron deficiency anemia, hypochromic anemia, microcytic anemia, chlorosis, hereditary sideroblastic anemia, idiopathic acquired sideroblastic anemia, red cell aplasia, megaloblastic anemia (e.g., pernicious anemia, (vitamin B12 deficiency) and folic acid deficiency anemia), aplastic anemia, hemolytic anemias (e.g., autoimmune helolytic anemia, microangiopathic hemolytic anemia, and paroxysmal nocturnal hemoglobinuria). The polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in treating, preventing, and/or diagnosing anemias associated with diseases including but not limited to, anemias associated with systemic lupus erythematosus, cancers, lymphomas, chronic renal disease, and enlarged spleens. The polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in treating, preventing, and/or diagnosing anemias arising from drug treatments such as anemias associated with methyldopa, dapsone, and/or sulfadrugs. Additionally, rhe polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in treating, preventing, and/or diagnosing anemias associated with abnormal red blood cell architecture including but not limited to, hereditary spherocytosis, hereditary elliptocytosis, glucose-6-phosphate dehydrogenase deficiency, and sickle cell anemia.

[0623] The polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in treating, preventing, and/or diagnosing hemoglobin abnormalities, (e.g., those associated with sickle cell anemia, hemoglobin C disease, hemoglobin S-C disease, and hemoglobin E disease). Additionally, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in diagnosing, prognosing, preventing, and/or treating thalassemias, including, but not limited to major and minor forms of alpha-thalassemia and beta-thalassemia.

[0624] In another embodiment, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in diagnosing, prognosing, preventing, and/or treating bleeding disorders including, but not limited to, thrombocytopenia (e.g., idiopathic thrombocytopenic purpura, and thrombotic thrombocytopenic purpura), Von Willebrand's disease, hereditary platelet disorders (e.g., storage pool disease such as Chediak-Higashi and Hermansky-Pudlak syndromes, thromboxane A2 dysfunction, thromboasthenia, and Bemard-Soulier syndrome), hemolytic-uremic syndrome, hemophelias such as hemophelia A or Factor VII deficiency and Christmas disease or Factor IX deficiency, Hereditary Hemorhhagic Telangiectsia, also known as Rendu-Osler-Weber syndrome, allergic purpura (Henoch Schonlein purpura) and disseminated intravascular coagulation.

[0625] The effect of the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention on the clotting time of blood may be monitored using any of the clotting tests known in the art including, but not limited to, whole blood partial thromboplastin time (PTT), the activated partial thromboplastin time (aPTT), the activated clotting time (ACT), the recalcified activated clotting time, or the Lee-White Clotting time.

[0626] Several diseases and a variety of drugs can cause platelet dysfunction. Thus, in a specific embodiment, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in diagnosing, prognosing, preventing, and/or treating acquired platelet dysfunction such as platelet dysfunction accompanying kidney failure, leukemia, multiple myeloma, cirrhosis of the liver, and systemic lupus erythematosus as well as platelet dysfunction associated with drug treatments, including treatment with aspirin, ticlopidine, nonsteroidal anti-inflammatory drugs (used for arthritis, pain, and sprains), and penicillin in high doses.

[0627] In another embodiment, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in diagnosing, prognosing, preventing, and/or treating diseases and disorders characterized by or associated with increased or decreased numbers of white blood cells. Leukopenia occurs when the number of white blood cells decreases below normal. Leukopenias include, but are not limited to, neutropenia and lymphocytopenia. An increase in the number of white blood cells compared to normal is known as leukocytosis. The body generates increased numbers of white blood cells during infection. Thus, leukocytosis may simply be a normal physiological parameter that reflects infection. Alternatively, leukocytosis may be an indicator of injury or other disease such as cancer. Leokocytoses, include but are not limited to, eosinophilia, and accumulations of macrophages. In specific embodiments, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in diagnosing, prognosing, preventing, and/or treating leukopenia. In other specific embodiments, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in diagnosing, prognosing, preventing, and/or treating leukocytosis

[0628] Leukopenia may be a generalized decreased in all types of white blood cells, or may be a specific depletion of particular types of white blood cells. Thus, in specific embodiments, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in diagnosing, prognosing, preventing, and/or treating decreases in neutrophil numbers, known as neutropenia. Neutropenias that may be diagnosed, prognosed, prevented, and/or treated by the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention include, but are not limited to, infantile genetic agranulocytosis, familial neutropenia, cyclic neutropenia, neutropenias resulting from or associated with dietary deficiencies (e.g., vitamin B 12 deficiency or folic acid deficiency), neutropenias resulting from or associated with drug treatments (e.g., antibiotic regimens such as penicillin treatment, sulfonamide treatment, anticoagulant treatment, anticonvulsant drugs, anti-thyroid drugs, and cancer chemotherapy), and neutropenias resulting from increased neutrophil destruction that may occur in association with some bacterial or viral infections, allergic disorders, autoimmune diseases, conditions in which an individual has an enlarged spleen (e.g., Felty syndrome, malaria and sarcoidosis), and some drug treatment regimens.

[0629] The polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in diagnosing, prognosing, preventing, and/or treating lymphocytopenias (decreased numbers of B and/or T lymphocytes), including, but not limited lymphocytopenias resulting from or associated with stress, drug treatments (e.g., drug treatment with corticosteroids, cancer chemotherapies, and/or radiation therapies), AIDS infection and/or other diseases such as, for example, cancer, rheumatoid arthritis, systemic lupus erythematosus, chronic infections, some viral infections and/or hereditary disorders (e.g., DiGeorge syndrome, Wiskott-Aldrich Syndome, severe combined immunodeficiency, ataxia telangiectsia).

[0630] The polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in diagnosing, prognosing, preventing, and/or treating diseases and disorders associated with macrophage numbers and/or macrophage function including, but not limited to, Gaucher's disease, Niemann-Pick disease, Letterer-Siwe disease and Hand-Schuller-Christian disease.

[0631] In another embodiment, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in diagnosing, prognosing, preventing, and/or treating diseases and disorders associated with eosinophil numbers and/or eosinophil function including, but not limited to, idiopathic hypereosinophilic syndrome, eosinophilia-myalgia syndrome, and Hand-Schuller-Christian disease.

[0632] In yet another embodiment, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in diagnosing, prognosing, preventing, and/or treating leukemias and lymphomas including, but not limited to, acute lymphocytic (lymphpblastic) leukemia (ALL), acute myeloid (myelocytic, myelogenous, myeloblastic, or myelomonocytic) leukemia, chronic lymphocytic leukemia (e.g., B cell leukemias, T cell leukemias, Sezary syndrome, and Hairy cell leukenia), chronic myelocytic (myeloid, myelogenous, or granulocytic) leukemia, Hodgkin's lymphoma, non-hodgkin's lymphoma, Burkitt's lymphoma, and mycosis fungoides.

[0633] In other embodiments, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in diagnosing, prognosing, preventing, and/or treating diseases and disorders of plasma cells including, but not limited to, plasma cell dyscrasias, monoclonal gammaopathies, monoclonal gammopathies of undetermined significance, multiple myeloma, macroglobulinemia, Waldenstrom's macroglobulinemia, cryoglobulinemia, and Raynaud's phenomenon.

[0634] In other embodiments, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in treating, preventing, and/or diagnosing myeloproliferative disorders, including but not limited to, polycythemia vera, relative polycythemia, secondary polycythemia, myelofibrosis, acute myelofibrosis, agnogenic myelod metaplasia, thrombocythemia, (including both primary and seconday thrombocythemia) and chronic myelocytic leukemia.

[0635] In other embodiments, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful as a treatment prior to surgery, to increase blood cell production.

[0636] In other embodiments, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful as an agent to enhance the migration, phagocytosis, superoxide production, antibody dependent cellular cytotoxicity of neutrophils, eosionophils and macrophages.

[0637] In other embodiments, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful as an agent to increase the number of stem cells in circulation prior to stem cells pheresis. In another specific embodiment, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful as an agent to increase the number of stem cells in circulation prior to platelet pheresis.

[0638] In other embodiments, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful as an agent to increase cytokine production.

[0639] In other embodiments, the polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention may be useful in preventing, diagnosing, and/or treating primary hematopoietic disorders.

[0640] Hyperproliferative Disorders

[0641] Reproductive system associated polynucleotides or polypeptides, or agonists or antagonists thereof, can be used to treat, prevent, diagnose and/or prognose hyperproliferative diseases, disorders, and/or conditions, including neoplasms.

[0642] In a specific embodiment, reproductive system associated polynucleotides or polypeptides, or agonists or antagonists thereof, can be used to treat, prevent, and/or diagnose hyperproliferative diseases, disorders, and/or conditions of the reproductive system.

[0643] In a preferred embodiment, reproductive system associated polynucleotides or polypeptides, or agonists or antagonists thereof, can be used to treat, prevent, and/or diagnose reproductive system neoplasms.

[0644] Reproductive system associated polynucleotides or polypeptides, or agonists or antagonists of the invention, may inhibit the proliferation of the disorder through direct or indirect interactions. Alternatively, reproductive system associated polynucleotides or polypeptides, or agonists or antagonists thereof, may proliferate other cells, which can inhibit the hyperproliferative disorder.

[0645] For example, by increasing an immune response, particularly increasing antigenic qualities of the hyperproliferative disorder or by proliferating, differentiating, or mobilizing T-cells, hyperproliferative diseases, disorders, and/or conditions can be treated, prevented, and/or diagnosed. This immune response may be increased by either enhancing an existing immune response, or by initiating a new immune response. Alternatively, decreasing an immune response may also be a method of treating, preventing, and/or diagnosing hyperproliferative diseases, disorders, and/or conditions, such as a chemotherapeutic agent.

[0646] Examples of hyperproliferative diseases, disorders, and/or conditions that can be treated, prevented, and/or diagnosed by reproductive system associated polynucleotides or polypeptides, or agonists or antagonists thereof, include, but are not limited to neoplasms located in the: prostate, colon, abdomen, bone, breast, digestive system, liver, pancreas, peritoneum, endocrine glands (adrenal, parathyroid, pituitary, testicles, ovary, thymus, thyroid), eye, head and neck, nervous (central and peripheral), lymphatic system, pelvic, skin, soft tissue, spleen, thoracic, and urogenital.

[0647] Similarly, other hyperproliferative disorders can also be treated or detected by polynucleotides or polypeptides, or agonists or antagonists of the present invention. Examples of such hyperproliferative disorders include, but are not limited to: Acute Childhood Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia, Acute Lymphocytic Leukemia, Acute Myeloid Leukemia, Adrenocortical Carcinoma, Adult (Primary) Hepatocellular Cancer, Adult (Primary) Liver Cancer, Adult Acute Lymphocytic Leukemia, Adult Acute Myeloid Leukemia, Adult Hodgkin's Disease, Adult Hodgkin's Lymphoma, Adult Lymphocytic Leukemia, Adult Non-Hodgkin's Lymphoma, Adult Primary Liver Cancer, Adult Soft Tissue Sarcoma, AIDS-Related Lymphoma, AIDS-Related Malignancies, Anal Cancer, Astrocytoma, Bile Duct Cancer, Bladder Cancer, Bone Cancer, Brain Stem Glioma, Brain Tumors, Breast Cancer, Cancer of the Renal Pelvis and Ureter, Central Nervous System (Primary) Lymphoma, Central Nervous System Lymphoma, Cerebellar Astrocytoma, Cerebral Astrocytoma, Cervical Cancer, Childhood (Primary) Hepatocellular Cancer, Childhood (Primary) Liver Cancer, Childhood Acute Lymphoblastic Leukemia, Childhood Acute Myeloid Leukemia, Childhood Brain Stem Glioma, Childhood Cerebellar Astrocytoma, Childhood Cerebral Astrocytoma, Childhood Extracranial Germ Cell Tumors, Childhood Hodgkin's Disease, Childhood Hodgkin's Lymphoma, Childhood Hypothalamic and Visual Pathway Glioma, Childhood Lymphoblastic Leukemia, Childhood Medulloblastoma, Childhood Non-Hodgkin's Lymphoma, Childhood Pineal and Supratentorial Primitive Neuroectodermal Tumors, Childhood Primary Liver Cancer, Childhood Rhabdomyosarcoma, Childhood Soft Tissue Sarcoma, Childhood Visual Pathway and Hypothalamic Glioma, Chronic Lymphocytic Leukemia, Chronic Myelogenous Leukemia, Colon Cancer, Cutaneous T-Cell Lymphoma, Endocrine Pancreas Islet Cell Carcinoma, Endometrial Cancer, Ependymoma, Epithelial Cancer, Esophageal Cancer, Ewing's Sarcoma and Related Tumors, Exocrine Pancreatic Cancer, Extracranial Germ Cell Tumor, Extragonadal Germ Cell Tumor, Extrahepatic Bile Duct Cancer, Eye Cancer, Female Breast Cancer, Gaucher's Disease, Gallbladder Cancer, Gastric Cancer, Gastrointestinal Carcinoid Tumor, Gastrointestinal Tumors, Germ Cell Tumors, Gestational Trophoblastic Tumor, Hairy Cell Leukemia, Head and Neck Cancer, Hepatocellular Cancer, Hodgkin's Disease, Hodgkin's Lymphoma, Hypergammaglobulinemia, Hypopharyngeal Cancer, Intestinal Cancers, Intraocular Melanoma, Islet Cell Carcinoma, Islet Cell Pancreatic Cancer, Kaposi's Sarcoma, Kidney Cancer, Laryngeal Cancer, Lip and Oral Cavity Cancer, Liver Cancer, Lung Cancer, Lymphoproliferative Disorders, Macroglobulinemia, Male Breast Cancer, Malignant Mesothelioma, Malignant Thymoma, Medulloblastoma, Melanoma, Mesothelioma, Metastatic Occult Primary Squamous Neck Cancer, Metastatic Primary Squamous Neck Cancer, Metastatic Squamous Neck Cancer, Multiple Myeloma, Multiple Myeloma/Plasma Cell Neoplasm, Myelodysplastic Syndrome, Myelogenous Leukemia, Myeloid Leukemia, Myeloproliferative Disorders, Nasal Cavity and Paranasal Sinus Cancer, Nasopharyngeal Cancer, Neuroblastoma, Non-Hodgkin's Lymphoma During Pregnancy, Nonmelanoma Skin Cancer, Non-Small Cell Lung Cancer, Occult Primary Metastatic Squamous Neck Cancer, Oropharyngeal Cancer, Osteo-/Malignant Fibrous Sarcoma, Osteosarcoma/Malignant Fibrous Histiocytoma, Osteosarcoma/Malignant Fibrous Histiocytoma of Bone, Ovarian Epithelial Cancer, Ovarian Germ Cell Tumor, Ovarian Low Malignant Potential Tumor, Pancreatic Cancer, Paraproteinemias, Purpura, Parathyroid Cancer, Penile Cancer, Pheochromocytoma, Pituitary Tumor, Plasma Cell Neoplasm/Multiple Mycloma, Primary Central Nervous System Lymphoma, Primary Liver Cancer, Prostate Cancer, Rectal Cancer, Renal Cell Cancer, Renal Pelvis and Ureter Cancer, Retinoblastoma, Rhabdomyosarcoma, Salivary Gland Cancer, Sarcoidosis Sarcomas, Sezary Syndrome, Skin Cancer, Small Cell Lung Cancer, Small Intestine Cancer, Soft Tissue Sarcoma, Squamous Neck Cancer, Stomach Cancer, Supratentorial Primitive Neuroectodermal and Pineal Tumors, T-Cell Lymphoma, Testicular Cancer, Thymoma, Thyroid Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter, Transitional Renal Pelvis and Ureter Cancer, Trophoblastic Tumors, Ureter and Renal Pelvis Cell Cancer, Urethral Cancer, Uterine Cancer, Uterine Sarcoma, Vaginal Cancer, Visual Pathway and Hypothalamic Glioma, Vulvar Cancer, Waldenstrom's Macroglobulinemia, Wilms' Tumor, and any other hyperproliferative disease, besides neoplasia, located in an organ system listed above.

[0648] In another preferred embodiment, polynucleotides or polypeptides, or agonists or antagonists of the present invention are used to diagnose, prognose, prevent, and/or treat premalignant conditions and to prevent progression to a neoplastic or malignant state, including but not limited to those disorders described above. Such uses are indicated in conditions known or suspected of preceding progression to neoplasia or cancer, in particular, where non-neoplastic cell growth consisting of hyperplasia, metaplasia, or most particularly, dysplasia has occurred (for review of such abnormal growth conditions, see Robbins and Angell, 1976, Basic Pathology, 2d Ed., W. B. Saunders Co., Philadelphia, pp. 68-79.)

[0649] Hyperplasia is a form of controlled cell proliferation, involving an increase in cell number in a tissue or organ, without significant alteration in structure or function. Hyperplastic disorders which can be diagnosed, prognosed, prevented, and/or treated with compositions of the invention (including polynucleotides, polypeptides, agonists or antagonists) include, but are not limited to, angiofollicular mediastinal lymph node hyperplasia, angiolymphoid hyperplasia with eosinophilia, atypical melanocytic hyperplasia, basal cell hyperplasia, benign giant lymph node hyperplasia, cementum hyperplasia, congenital adrenal hyperplasia, congenital sebaceous hyperplasia, cystic hyperplasia, cystic hyperplasia of the breast, denture hyperplasia, ductal hyperplasia, endometrial hyperplasia, fibromuscular hyperplasia, focal epithelial hyperplasia, gingival hyperplasia, inflammatory fibrous hyperplasia, inflammatory papillary hyperplasia, intravascular papillary endothelial hyperplasia, nodular hyperplasia of prostate, nodular regenerative hyperplasia, pseudoepitheliomatous hyperplasia, senile sebaceous hyperplasia, and verrucous hyperplasia.

[0650] Metaplasia is a form of controlled cell growth in which one type of adult or fully differentiated cell substitutes for another type of adult cell. Metaplastic disorders which can be diagnosed, prognosed, prevented, and/or treated with compositions of the invention (including polynucleotides, polypeptides, agonists or antagonists) include, but are not limited to, agnogenic myeloid metaplasia, apocrine metaplasia, atypical metaplasia, autoparenchymatous metaplasia, connective tissue metaplasia, epithelial metaplasia, intestinal metaplasia, metaplastic anemia, metaplastic ossification, metaplastic polyps, myeloid metaplasia, primary myeloid metaplasia, secondary myeloid metaplasia, squamous metaplasia, squamous metaplasia of amnion, and symptomatic myeloid metaplasia.

[0651] Dysplasia is frequently a forerunner of cancer, and is found mainly in the epithelia; it is the most disorderly form of non-neoplastic cell growth, involving a loss in individual cell uniformity and in the architectural orientation of cells. Dysplastic cells often have abnormally large, deeply stained nuclei, and exhibit pleomorphism. Dysplasia characteristically occurs where there exists chronic irritation or inflammation. Dysplastic disorders which can be diagnosed, prognosed, prevented, and/or treated with compositions of the invention (including polynucleotides, polypeptides, agonists or antagonists) include, but are not limited to, anhidrotic ectodermal dysplasia, anterofacial dysplasia, asphyxiating thoracic dysplasia, atriodigital dysplasia, bronchopulmonary dysplasia, cerebral dysplasia, cervical dysplasia, chondroectodermal dysplasia, cleidocranial dysplasia, congenital ectodermal dysplasia, craniodiaphysial dysplasia, craniocarpotarsal dysplasia, craniometaphysial dysplasia, dentin dysplasia, diaphysial dysplasia, ectodermal dysplasia, enamel dysplasia, encephalo-ophthalmic dysplasia, dysplasia epiphysialis hemimelia, dysplasia epiphysialis multiplex, dysplasia epiphysialis punctata, epithelial dysplasia, faciodigitogenital dysplasia, familial fibrous dysplasia of jaws, familial white folded dysplasia, fibromuscular dysplasia, fibrous dysplasia of bone, florid osseous dysplasia, hereditary renal-retinal dysplasia, hidrotic ectodermal dysplasia, hypohidrotic ectodermal dysplasia, lymphopenic thymic dysplasia, mammary dysplasia, mandibulofacial dysplasia, metaphysial dysplasia, Mondini dysplasia, monostotic fibrous dysplasia, mucoepithelial dysplasia, multiple epiphysial dysplasia, oculoauriculovertebral dysplasia, oculodentodigital dysplasia, oculovertebral dysplasia, odontogenic dysplasia, ophthalmomandibulomelic dysplasia, periapical cemental dysplasia, polyostotic fibrous dysplasia, pseudoachondroplastic spondyloepiphysial dysplasia, retinal dysplasia, septo-optic dysplasia, spondyloepiphysial dysplasia, and ventriculoradial dysplasia.

[0652] Additional pre-neoplastic disorders which can be diagnosed, prognosed, prevented, and/or treated with compositions of the invention (including polynucleotides, polypeptides, agonists or antagonists) include, but are not limited to, benign dysproliferative disorders (e.g., benign tumors, fibrocystic conditions, tissue hypertrophy, intestinal polyps, colon polyps, and esophageal dysplasia), leukoplakia, keratoses, Bowen's disease, Farmer's Skin, solar cheilitis, and solar keratosis.

[0653] In another embodiment, a polypeptide of the invention, or polynucleotides, antibodies, agonists, or antagonists corresponding to that polypeptide, may be used to diagnose and/or prognose disorders associated with the tissue(s) in which the polypeptide of the invention is expressed, including one, two, three, four, five, or more tissues disclosed in Table 1A, 7 (Tissue Distribution Library Code).

[0654] In another embodiment, polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention conjugated to a toxin or a radioactive isotope, as described herein, may be used to treat cancers and neoplasms, including, but not limited to those described herein. In a further preferred embodiment, polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention conjugated to a toxin or a radioactive isotope, as described herein, may be used to treat acute myelogenous leukemia.

[0655] Additionally, polynucleotides, polypeptides, and/or agonists or antagonists of the invention may affect apoptosis, and therefore, would be useful in treating a number of diseases associated with increased cell survival or the inhibition of apoptosis. For example, diseases associated with increased cell survival or the inhibition of apoptosis that could be diagnosed, prognosed, prevented, and/or treated by polynucleotides, polypeptides, and/or agonists or antagonists of the invention, include cancers (such as follicular lymphomas, carcinomas with p53 mutations, and hormone-dependent tumors, including, but not limited to colon cancer, cardiac tumors, pancreatic cancer, melanoma, retinoblastoma, glioblastoma, lung cancer, intestinal cancer, testicular cancer, stomach cancer, neuroblastoma, myxoma, myoma, lymphoma, endothelioma, osteoblastoma, osteoclastoma, osteosarcoma, chondrosarcoma, adenoma, breast cancer, prostate cancer, Kaposi's sarcoma and ovarian cancer); autoimmune disorders such as, multiple sclerosis, Sjogren's syndrome, Hashimoto's thyroiditis, biliary cirrhosis, Behcet's disease, Crohn's disease, polymyositis, systemic lupus erythematosus and immune-related glomerulonephritis and rheumatoid arthritis) and viral infections (such as herpes viruses, pox viruses and adenoviruses), inflammation, graft v. host disease, acute graft rejection, and chronic graft rejection.

[0656] In preferred embodiments, polynucleotides, polypeptides, and/or agonists or antagonists of the invention are used to inhibit growth, progression, and/or metastasis of cancers, in particular those listed above.

[0657] Additional diseases or conditions associated with increased cell survival that could be diagnosed, prognosed, prevented, and/or treated by polynucleotides, polypeptides, and/or agonists or antagonists of the invention, include, but are not limited to, progression, and/or metastases of malignancies and related disorders such as leukemia (including acute leukemias (e.g., acute lymphocytic leukemia, acute myelocytic leukemia (including myeloblastic, promyelocytic, myelomonocytic, monocytic, and erythroleukemia)) and chronic leukemias (e.g., chronic myelocytic (granulocytic) leukemia and chronic lymphocytic leukemia)), polycythemia vera, lymphomas (e.g., Hodgkin's disease and non-Hodgkin's disease), multiple myeloma, Waldenstrom's macroglobulinemia, heavy chain disease, and solid tumors including, but not limited to, sarcomas and carcinomas such as fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chordoma, angiosarcoma, endotheliosarcoma, lymphangiosarcoma, lymphangioendotheliosarcoma, synovioma, mesothelioma, Ewing's tumor, leiomyosarcoma, rhabdomyosarcoma, colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, sebaceous gland carcinoma, papillary carcinoma, papillary adenocarcinomas, cystadenocarcinoma, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilm's tumor, cervical cancer, testicular tumor, lung carcinoma, small cell lung carcinoma, bladder carcinoma, epithelial carcinoma, glioma, astrocytoma, medulloblastoma, craniopharyngioma, ependymoma, pinealoma, emangioblastoma, acoustic neuroma, oligodendroglioma, menangioma, melanoma, neuroblastoma, and retinoblastoma.

[0658] Diseases associated with increased apoptosis that could be diagnosed, prognosed, prevented, and/or treated by polynucleotides, polypeptides, and/or agonists or antagonists of the invention, include AIDS; neurodegenerative disorders (such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, retinitis pigmentosa, cerebellar degeneration and brain tumor or prior associated disease); autoimmune disorders (such as, multiple sclerosis, Sjogren's syndrome, Hashimoto's thyroiditis, biliary cirrhosis, Behcet's disease, Crohn's disease, polymyositis, systemic lupus erythematosus and immune-related glomerulonephritis and rheumatoid arthritis) myelodysplastic syndromes (such as aplastic anemia), graft v. host disease, ischemic injury (such as that caused by myocardial infarction, stroke and reperfusion injury), liver injury (e.g., hepatitis related liver injury, ischemia/reperfusion injury, cholestosis (bile duct injury) and liver cancer); toxin-induced liver disease (such as that caused by alcohol), septic shock, cachexia and anorexia.

[0659] Hyperproliferative diseases and/or disorders that could be diagnosed, prognosed, prevented, and/or treated by polynucleotides, polypeptides, and/or agonists or antagonists of the invention, include, but are not limited to, neoplasms located in the liver, abdomen, bone, breast, digestive system, pancreas, peritoneum, endocrine glands (adrenal, parathyroid, pituitary, testicles, ovary, thymus, thyroid), eye, head and neck, nervous system (central and peripheral), lymphatic system, pelvis, skin, soft tissue, spleen, thorax, and urogenital tract.

[0660] Similarly, other hyperproliferative disorders can also be diagnosed, prognosed, prevented, and/or treated by polynucleotides, polypeptides, and/or agonists or antagonists of the invention. Examples of such hyperproliferative disorders include, but are not limited to: hypergammaglobulinemia, lymphoproliferative disorders, paraproteinemias, purpura, sarcoidosis, Sezary Syndrome, Waldenstron's macroglobulinemia, Gaucher's Disease, histiocytosis, and any other hyperproliferative disease, besides neoplasia, located in an organ system listed above.

[0661] One preferred embodiment utilizes polynucleotides of the present invention to inhibit aberrant cellular division, by gene therapy using the present invention, and/or protein fusions or fragments thereof.

[0662] Thus, the present invention provides a method for treating cell proliferative diseases, disorders, and/or conditions by inserting into an abnormally proliferating cell a polynucleotide of the present invention, wherein said polynucleotide represses said cell proliferation, disease, disorder, and/or condition.

[0663] In a preferred embodiment, the present invention provides a method for treating cell proliferative diseases, disorders and/or conditions of the reproductive system by inserting into a cell, a polynucleotide of the present invention, wherein said polynucleotide represses said cell proliferation, disease and/or disorder.

[0664] Another embodiment of the present invention provides a method of treating cell-proliferative diseases, disorders, and/or conditions in individuals comprising administration of one or more active gene copies of the present invention to an abnormally proliferating cell or cells. In a preferred embodiment, polynucleotides of the present invention is a DNA construct comprising a recombinant expression vector effective in expressing a DNA sequence encoding said polynucleotides. In another preferred embodiment of the present invention, the DNA construct encoding the polynucleotides of the present invention is inserted into cells to be treated utilizing a retrovirus, or more preferably an adenoviral vector (see, e.g., G J. Nabel, et. al., PNAS 96: 324-326 (1999), which is hereby incorporated by reference). In a most preferred embodiment, the viral vector is defective and will not transform non-proliferating cells, only proliferating cells. Moreover, in a preferred embodiment, the polynucleotides of the present invention inserted into proliferating cells either alone, or in combination with or fused to other polynucleotides, can then be modulated via an external stimulus (i.e., magnetic, specific small molecule, chemical, or drug administration, etc.), which acts upon the promoter upstream of said polynucleotides to induce expression of the encoded protein product. As such the beneficial therapeutic affect of the present invention may be expressly modulated (i.e., to increase, decrease, or inhibit expression of the present invention) based upon said external stimulus.

[0665] Polynucleotides of the present invention may be useful in repressing expression of oncogenic genes or antigens. By “repressing expression of the oncogenic genes” is intended the suppression of the transcription of the gene, the degradation of the gene transcript (pre-message RNA), the inhibition of splicing, the destruction of the messenger RNA, the prevention of the post-translational modifications of the protein, the destruction of the protein, or the inhibition of the normal function of the protein.

[0666] For local administration to abnormally proliferating cells, polynucleotides of the present invention may be administered by any method known to those of skill in the art including, but not limited to transfection, electroporation, microinjection of cells, or in vehicles such as liposomes, lipofectin, or as naked polynucleotides, or any other method described throughout the specification. The polynucleotide of the present invention may be delivered by known gene delivery systems such as, but not limited to, retroviral vectors (Gilboa, J. Virology 44:845 (1982); Hocke, Nature 320:275 (1986); Wilson, et al., Proc. Natl. Acad. Sci. U.S.A. 85:3014), vaccinia virus system (Chakrabarty et al., Mol. Cell Biol. 5:3403 (1985) or other efficient DNA delivery systems (Yates et al., Nature 313:812 (1985)) known to those skilled in the art. These references are exemplary only and are hereby incorporated by reference. In order to specifically deliver or transfect cells which are abnormally proliferating and spare non-dividing cells, it is preferable to utilize a retrovirus, or adenoviral (as described in the art and elsewhere herein) delivery system known to those of skill in the art. Since host DNA replication is required for retroviral DNA to integrate and the retrovirus will be unable to self replicate due to the lack of the retrovirus genes needed for its life cycle. Utilizing such a retroviral delivery system for polynucleotides of the present invention will target said gene and constructs to abnormally proliferating cells and will spare the non-dividing normal cells.

[0667] The polynucleotides of the present invention may be delivered directly to cell proliferative disorder/disease sites in internal organs, body cavities and the like by use of imaging devices used to guide an injecting needle directly to the disease site. The polynucleotides of the present invention may also be administered to disease sites at the time of surgical intervention.

[0668] By “cell proliferative disease” is meant any human or animal disease or disorder, affecting any one or any combination of organs, cavities, or body parts, which is characterized by single or multiple local abnormal proliferations of cells, groups of cells, or tissues, whether benign or malignant.

[0669] Any amount of the polynucleotides of the present invention may be administered as long as it has a biologically inhibiting effect on the proliferation of the treated cells. Moreover, it is possible to administer more than one of the polynucleotide of the present invention simultaneously to the same site. By “biologically inhibiting” is meant partial or total growth inhibition as well as decreases in the rate of proliferation or growth of the cells. The biologically inhibitory dose may be determined by assessing the effects of the polynucleotides of the present invention on target malignant or abnormally proliferating cell growth in tissue culture, tumor growth in animals and cell cultures, or any other method known to one of ordinary skill in the art.

[0670] The present invention is further directed to antibody-based therapies which involve administering of anti-polypeptides and anti-polynucleotide antibodies to a mammalian, preferably human, patient for treating one or more of the described diseases, disorders, and/or conditions. Methods for producing anti-polypeptides and anti-polynucleotide antibodies polyclonal and monoclonal antibodies are described in detail elsewhere herein. Such antibodies may be provided in pharmaceutically acceptable compositions as known in the art or as described herein.

[0671] A summary of the ways in which the antibodies of the present invention may be used therapeutically includes binding polynucleotides or polypeptides of the present invention locally or systemically in the body or by direct cytotoxicity of the antibody, e.g., as mediated by complement (CDC) or by effector cells (ADCC). Some of these approaches are described in more detail below. Armed with the teachings provided herein, one of ordinary skill in the art will know how to use the antibodies of the present invention for diagnostic, monitoring or therapeutic purposes without undue experimentation.

[0672] In particular, the antibodies, fragments and derivatives of the present invention are useful for treating a subject having or developing cell proliferative and/or differentiation diseases, disorders, and/or conditions as described herein. Such treatment comprises administering a single or multiple doses of the antibody, or a fragment, derivative, or a conjugate thereof.

[0673] The antibodies of this invention may be advantageously utilized in combination with other monoclonal or chimeric antibodies, or with lymphokines or hematopoietic growth factors, for example, which serve to increase the number or activity of effector cells which interact with the antibodies.

[0674] It is preferred to use high affinity and/or potent in vivo inhibiting and/or neutralizing antibodies against polypeptides or polynucleotides of the present invention, fragments or regions thereof, for both immunoassays directed to and therapy of diseases, disorders, and/or conditions related to polynucleotides or polypeptides, including fragments thereof, of the present invention. Such antibodies, fragments, or regions, will preferably have an affinity for polynucleotides or polypeptides, including fragments thereof. Preferred binding affinities include those with a dissociation constant or Kd less than 5×10⁻⁶M, 10⁻⁶M, 5×10 ⁻⁷M, 10⁻⁷M, 5×10⁻⁸M, 10⁻⁸M, 5×10⁻⁹M, 10⁻⁹M, 5×10⁻¹⁰M, 10⁻¹⁰M, 5×10⁻¹¹M, 5×10⁻¹²M, 10⁻¹²M, 5×10⁻¹³M, 10⁻¹³ M, 5×10⁻¹⁴M, 10⁻¹⁴M, 5×10⁻¹⁵M, and 10⁻¹⁵M.

[0675] Moreover, reproductive system antigen polypeptides of the present invention or fragments thereof, are useful in inhibiting the angiogenesis of proliferative cells or tissues, either alone, as a protein fusion, or in combination with other polypeptides directly or indirectly, as described elsewhere herein. In a most preferred embodiment, said anti-angiogenesis effect may be achieved indirectly, for example, through the inhibition of hematopoietic, tumor-specific cells, such as tumor-associated macrophages (see, e.g., Joseph I B, et al. J Natl Cancer Inst, 90(21):1648-53 (1998), which is hereby incorporated by reference). Antibodies directed to polypeptides or polynucleotides of the present invention may also result in inhibition of angiogenesis directly, or indirectly (see, e.g., Witte L, et al., Cancer Metastasis Rev. 17(2):155-61 (1998), which is hereby incorporated by reference)).

[0676] Polypeptides, including protein fusions, of the present invention, or fragments thereof may be useful in inhibiting proliferative cells or tissues through the induction of apoptosis. Said polypeptides may act either directly, or indirectly to induce apoptosis of proliferative cells and tissues, for example in the activation of a death-domain receptor, such as tumor necrosis factor (TNF) receptor-1, CD95 (Fas/APO-1), TNF-receptor-related apoptosis-mediated protein (TRAMP) and TNF-related apoptosis-inducing ligand (TRAIL) receptor-1 and -2 (see, e.g., Schulze-Osthoff K, et.al., Eur J Biochem 254(3):439-59 (1998), which is hereby incorporated by reference). Moreover, in another preferred embodiment of the present invention, said polypeptides may induce apoptosis through other mechanisms, such as in the activation of other proteins which will activate apoptosis, or through stimulating the expression of said proteins, either alone or in combination with small molecule drugs or adjuvants, such as apoptonin, galectins, thioredoxins, antiinflammatory proteins (See for example, Mutat. Res. 400(1-2):447-55 (1998), Med Hypotheses.50(5):423-33 (1998), Chem. Biol. Interact. Apr 24;111-112:23-34 (1998), J. Mo. Med. 76(6):402-12 (1998), Int. J. Tissue React. 20(l):3-15 (1998), which are all hereby incorporated by reference).

[0677] Polypeptides, including protein fusions to, or fragments thereof, of the present invention are useful in inhibiting the metastasis of proliferative cells or tissues. Inhibition may occur as a direct result of administering polypeptides, or antibodies directed to said polypeptides as described elsewhere herein, or indirectly, such as activating the expression of proteins known to inhibit metastasis, for example alpha 4 integrins, (See, e.g., Curr Top Microbiol Immunol 1998;231:125-41, which is hereby incorporated by reference). Such therapeutic affects of the present invention may be achieved either alone, or in combination with small molecule drugs or adjuvants.

[0678] In another embodiment, the invention provides a method of delivering compositions containing the polypeptides of the invention (e.g., compositions containing polypeptides or anti-reproductive system antigen polypeptide antibodies associated with heterologous polypeptides, heterologous nucleic acids, toxins, or prodrugs) to targeted cells expressing the polypeptide of the present invention. reproductive system antigen polypeptides or anti- reproductive system antigen polypeptide antibodies of the invention may be associated with heterologous polypeptides, heterologous nucleic acids, toxins, or prodrugs via hydrophobic, hydrophilic, ionic and/or covalent interactions.

[0679] Polypeptides, protein fusions to, or fragments thereof, of the present invention are useful in enhancing the immunogenicity and/or antigenicity of proliferating cells or tissues, either directly, such as would occur if the polypeptides of the present invention ‘vaccinated’ the immune response to respond to proliferative antigens and immunogens, or indirectly, such as in activating the expression of proteins known to enhance the immune response (e.g. chemokines), to said antigens and immunogens.

[0680] Urinary System Disorders

[0681] Polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention, may be used to treat, prevent, diagnose, and/or prognose disorders of the urinary system, including but not limited to disorders of the renal system, bladder, ureters, and urethra. Renal disorders include, but are not limited to, kidney failure, nephritis, blood vessel disorders of kidney, metabolic and congenital kidney disorders, urinary disorders of the kidney, autoimmune disorders, sclerosis and necrosis, electrolyte imbalance, and kidney cancers.

[0682] Kidney failure diseases include, but are not limited to, acute kidney failure, chronic kidney failure, atheroembolic renal failure, and end-stage renal disease. Inflammatory diseases of the kidney include acute glomerulonephritis, postinfectious glomerulonephritis, rapidly progressive glomerulonephritis, nephrotic syndrome, membranous glomerulonephritis, familial nephrotic syndrome, membranoproliferative glomerulonephritis I and II, mesangial proliferative glomerulonephritis, chronic glomerulonephritis, acute tubulointerstitial nephritis, chronic tubulointerstitial nephritis, acute post-streptococcal glomerulonephritis (PSGN), pyelonephritis, lupus nephritis, chronic nephritis, interstitial nephritis, and post-streptococcal glomerulonephritis.

[0683] Blood vessel disorders of the kidneys include, but are not limited to, kidney infarction, atheroembolic kidney disease, cortical necrosis, malignant nephrosclerosis, renal vein thrombosis, renal underperfusion, renal ischemia-reperfusion, renal artery embolism, and renal artery stenosis. Kidney disorders resulting form urinary tract problems include, but are not limited to, pyelonephritis, hydronephrosis, urolithiasis (renal lithiasis, nephrolithiasis), reflux nephropathy, urinary tract infections, urinary retention, and acute or chronic unilateral obstructive uropathy.

[0684] Metabolic and congenital disorders of the kidneys include, but are not limited to, renal tubular acidosis, renal glycosuria, nephrogenic diabetes insipidus, cystinuria, Fanconi's syndrome, vitamin D-resistant rickets, Hartnup disease, Bartter's syndrome, Liddle's syndrome, polycystic kidney disease, medullary cystic disease, medullary sponge kidney, Alport's syndrome, nail-patella syndrome, congenital nephrotic syndrome, CRUSH syndrome, horseshoe kidney, diabetic nephropathy, nephrogenic diabetes insipidus, analgesic nephropathy, kidney stones, and membranous nephropathy, Kidney disorders resulting from an autoimmune response include, but are not limited to, systemic lupus erythematosus (SLE), Goodpasture syndrome, IgA nephropathy, and IgM mesangial proliferative glomerulonephritis.

[0685] Sclerotic or necrotic disorders of the kidney include, but are not limited to, glomerulosclerosis, diabetic nephropathy, focal segmental glomerulosclerosis (FSGS), necrotizing glomerulonephritis, and renal papillary necrosis. Kidneys may also develop carcinomas, including, but not limited to, hypemephroma, nephroblastoma, renal cell cancer, transitional cell cancer, squamous cell cancer, and Wilm's tumor.

[0686] Kidney disorders may also result in electrolyte imbalances, including, but not limited to, nephrocalcinosis, pyunria, edema, hydronephritis, proteinuria, hyponatremia, hypematremia, hypokalemia, hyperkalemia, hypocalcemia, hypercalcemia, hypophosphatemia, and hyperphosphatemia.

[0687] Bladder disorders include, but are not limited to, benign prostatic hyperplasia (BPH), interstitial cystitis (IC), prostatitis, proteinuria, urinary tract infections, urinary incontinence, urinary retention. Disorders of the ureters and urethra include, but are not limited to, acute or chronic unilateral obstructive uropathy. The bladder, ureters, and urethra may also develop carcinomas, including, but not limited to, superficial bladder cancer, invasive bladder cancer, carcinoma of the ureter, and urethra cancers.

[0688] Polypeptides may be administered using any method known in the art, including, but not limited to, direct needle injection at the delivery site, intravenous injection, topical administration, catheter infusion, biolistic injectors, particle accelerators, gelfoam sponge depots, other commercially available depot materials, osmotic pumps, oral or suppositorial solid pharmaceutical formulations, decanting or topical applications during surgery, aerosol delivery. Such methods are known in the art. Polypeptides may be administered as part of a Therapeutic, described in more detail below. Methods of delivering polynucleotides are described in more detail herein.

[0689] Cardiovascular Disorders

[0690] Polynucleotides or polypeptides, or agonists or antagonists of the present invention, may be used to treat, prevent, diagnose, and/or prognose cardiovascular disorders, including, but not limited to, peripheral artery disease, such as limb ischemia.

[0691] Cardiovascular disorders include cardiovascular abnormalities, such as arterio-arterial fistula, arteriovenous fistula, cerebral arteriovenous malformations, congenital heart defects, pulmonary atresia, and Scimitar Syndrome. Congenital heart defects include aortic coarctation, cor triatriatum, coronary vessel anomalies, crisscross heart, dextrocardia, patent ductus arteriosus, Ebstein's anomaly, Eisenmenger complex, hypoplastic left heart syndrome, levocardia, tetralogy of fallot, transposition of great vessels, double outlet right ventricle, tricuspid atresia, persistent truncus arteriosus, total anomalous pulmonary venous connection, hypoplastic left heart syndrome, and heart septal defects, such as aortopulmonary septal defect, endocardial cushion defects, Lutembacher's Syndrome, atrioventricular canal defect, trilogy of Fallot, ventricular heart septal defects.

[0692] Cardiovascular disorders also include heart disease, such as arrhythmias, carcinoid heart disease, high cardiac output, low cardiac output, cardiac tamponade, endocarditis (including bacterial), heart aneurysm, cardiac arrest, sudden cardiac death, congestive heart failure, congestive cardiomyopathy, paroxysmal dyspnea, cardiac edema, heart hypertrophy, congestive cardiomyopathy, left ventricular hypertrophy, right ventricular hypertrophy, post-infarction heart rupture, ventricular septal rupture, heart valve diseases, myocardial diseases, myocardial ischemia, pericardial effusion, pericarditis (including constrictive and tuberculous), pneumopericardium, postpericardiotomy syndrome, pulmonary heart disease, rheumatic heart disease, ventricular dysfunction, hyperemia, cardiovascular pregnancy complications, Scimitar Syndrome, diastolic dysfunction, enlarged heart, heart block, J-curve phenomenon, rheumatic heart disease, Marfan syndrome, cardiovascular syphilis, and cardiovascular tuberculosis.

[0693] Arrhythmias include sinus arrhythmia, atrial fibrillation, atrial flutter, bradycardia, extrasystole, Adams-Stokes Syndrome, bundle-branch block, sinoatrial block, long QT syndrome, parasystole, Lown-Ganong-Levine Syndrome, Mahaim-type pre-excitation syndrome, Wolff-Parkinson-White syndrome, sick sinus syndrome, tachycardias, and ventricular fibrillation. Tachycardias include paroxysmal tachycardia, supraventricular tachycardia, accelerated idioventricular rhythm, atrioventricular nodal reentry tachycardia, ectopic atrial tachycardia, ectopic junctional tachycardia, sinoatrial nodal reentry tachycardia, sinus tachycardia, Torsades de Pointes, and ventricular tachycardia.

[0694] Heart valve disease include aortic valve insufficiency, aortic valve stenosis, heart murmurs, aortic valve prolapse, mitral valve prolapse, tricuspid valve prolapse, mitral valve insufficiency, mitral valve stenosis, pulmonary atresia, pulmonary valve insufficiency, pulmonary valve stenosis, tricuspid atresia, tricuspid valve insufficiency, tricuspid valve stenosis, and bicuspid aortic valve.

[0695] Myocardial diseases include alcoholic cardiomyopathy, congestive cardiomyopathy, hypertrophic cardiomyopathy, aortic subvalvular stenosis, pulmonary subvalvular stenosis, restrictive cardiomyopathy, Chagas cardiomyopathy, endocardial fibroelastosis, endomyocardial fibrosis, Kearns Syndrome, Barth syndrome, myocardial reperfusion injury, and myocarditis.

[0696] Myocardial ischemias include coronary disease, such as angina pectoris, Prinzmetal's angina, unstable angina, coronary aneurysm, coronary arteriosclerosis, coronary thrombosis, coronary vasospasm, myocardial infarction and myocardial stunning.

[0697] Cardiovascular diseases also include vascular diseases such as aneurysms, angiodysplasia, angiomatosis, bacillary angiomatosis, Hippel-Lindau Disease, Klippel-Trenaunay-Weber Syndrome, Sturge-Weber Syndrome, angioneurotic edema, aortic diseases, Takayasu's Arteritis, aortitis, Leriche's Syndrome, arterial occlusive diseases, arteritis, enarteritis, polyarteritis nodosa, cerebrovascular disorders, diabetic angiopathies, diabetic retinopathy, embolisms, thrombosis, erythromelalgia, hemorrhoids, hepatic veno-occlusive disease, hypertension, hypotension (shock), ischemia, peripheral vascular diseases, phlebitis, superficial phlebitis, pulmonary veno-occlusive disease, chronic obstructive pulmonary disease, Buerger's disease, Raynaud's disease, CREST syndrome, retinal vein occlusion, Scimitar syndrome, superior vena cava syndrome, telangiectasia, atacia telangiectasia, hereditary hemorrhagic telangiectasia, deep vein thrombosis, varicocele, varicose veins, varicose ulcer, vasculitis, and venous insufficiency.

[0698] Aneurysms include dissecting aneurysms, false aneurysms, infected aneurysms, ruptured aneurysms, aortic aneurysms, cerebral aneurysms, coronary aneurysms, heart aneurysms, and iliac aneurysms.

[0699] Arterial occlusive diseases include arteriosclerosis, arteriolosclerosis, atherosclerosis, intermittent claudication, carotid stenosis, fibromuscular dysplasias, mesenteric vascular occlusion, Moyamoya disease, renal artery obstruction, retinal artery occlusion, and thromboangiitis obliterans.

[0700] Cerebrovascular disorders include carotid artery diseases, cerebral amyloid angiopathy, cerebral aneurysm, cerebral anoxia, cerebral arteriosclerosis, cerebral arteriovenous malformation, cerebral artery diseases, cerebral embolism and thrombosis, carotid artery thrombosis, sinus thrombosis, Wallenberg's syndrome, cerebral hemorrhage, epidural hematoma, subdural hematoma, subaraxhnoid hemorrhage, cerebral infarction, cerebral ischemia (including transient), subclavian steal syndrome, periventricular leukomalacia, vascular headache, cluster headache, migraine, and vertebrobasilar insufficiency.

[0701] Embolisms include air embolisms, amniotic fluid embolisms, cholesterol embolisms, blue toe syndrome, fat embolisms, pulmonary embolisms, and thromoboembolisms. Thrombosis include coronary thrombosis, hepatic vein thrombosis, deep vein thrombosis, retinal vein occlusion, carotid artery thrombosis, sinus thrombosis, Wallenberg's syndrome, and thrombophlebitis.

[0702] Ischemia includes cerebral ischemia, ischemic colitis, silent ischemia, compartment syndromes, anterior compartment syndrome, myocardial ischemia, reperfusion injuries, and peripheral limb ischemia. Vasculitis includes aortitis, arteritis, Behcet's Syndrome, Churg-Strauss Syndrome, mucocutaneous lymph node syndrome, thromboangiitis obliterans, hypersensitivity vasculitis, Schoenlein-Henoch purpura, allergic cutaneous vasculitis, and Wegener's granulomatosis.

[0703] Cardiovascular diseases can also occur due to electrolyte imbalances that include, but are not limited to hyponatremia, hypematremia, hypokalemia, hyperkalemia, hypocalcemia, hypercalcemia, hypophosphatemia, and hyperphophatemia. Neoplasm and/or cancers of the cardiovascular system include, but are not limited to, myxomas, fibromas, and rhabdomyomas.

[0704] Polypeptides may be administered using any method known in the art, including, but not limited to, direct needle injection at the delivery site, intravenous injection, topical administration, catheter infusion, biolistic injectors, particle accelerators, gelfoam sponge depots, other commercially available depot materials, osmotic pumps, oral or suppositorial solid pharmaceutical formulations, decanting or topical applications during surgery, aerosol delivery. Such methods are known in the art. Polypeptides may be administered as part of a Therapeutic, described in more detail below. Methods of delivering polynucleotides are described in more detail herein.

[0705] Respiratory Disorders

[0706] Polynucleotides or polypeptides, or agonists or antagonists of the present invention may be used to treat, prevent, diagnose, and/or prognose diseases and/or disorders of the respiratory system.

[0707] Diseases and disorders of the respiratory system include, but are not limited to, nasal vestibulitis, nonallergic rhinitis (e.g., acute rhinitis, chronic rhinitis, atrophic rhinitis, vasomotor rhinitis), nasal polyps, and sinusitis, juvenile angiofibromas, cancer of the nose and juvenile papillomas, vocal cord polyps, nodules (singer's nodules), contact ulcers, vocal cord paralysis, laryngoceles, pharyngitis (e.g., viral and bacterial), tonsillitis, tonsillar cellulitis, parapharyngeal abscess, laryngitis, laryngoceles, and throat cancers (e.g., cancer of the nasopharynx, tonsil cancer, larynx cancer), lung cancer (e.g., squamous cell carcinoma, small cell (oat cell) carcinoma, large cell carcinoma, and adenocarcinoma), allergic disorders (eosinophilic pneumonia, hypersensitivity pneumonitis (e.g., extrinsic allergic alveolitis, allergic interstitial pneumonitis, organic dust pneumoconiosis, allergic bronchopulmonary aspergillosis, asthma, Wegener's granulomatosis (granulomatous vasculitis), Goodpasture's syndrome)), pneumonia (e.g., bacterial pneumonia (e.g., Streptococcus pneumoniae (pneumoncoccal pneumonia), Staphylococcus aureus (staphylococcal pneumonia), Gram-negative bacterial pneumonia (caused by, e.g., Klebsiella and Pseudomas spp.), Mycoplasma pneumoniae pneumonia, Hemophilus influenzae pneumonia, Legionella pneumophila (Legionnaires' disease), and Chlamydia psittaci (Psittacosis)), and viral pneumonia (e.g., influenza, chickenpox (varicella).

[0708] Additional diseases and disorders of the respiratory system include, but are not limited to bronchiolitis, polio (poliomyelitis), croup, respiratory syncytial viral infection, mumps, erythema infectiosum (fifth disease), roseola infantum, progressive rubella panencephalitis, german measles, and subacute sclerosing panencephalitis), fungal pneumonia (e.g., Histoplasmosis, Coccidioidomycosis, Blastomycosis, fungal infections in people with severely suppressed immune systems (e.g., cryptococcosis, caused by Cryptococcus neoformans; aspergillosis, caused by Aspergillus spp.; candidiasis, caused by Candida; and mucormycosis)), Pneumocystis carinii (pneumocystis pneumonia), atypical pneumonias (e.g., Mycoplasma and Chlamydia spp.), opportunistic infection pneumonia, nosocomial pneumonia, chemical pneumonitis, and aspiration pneumonia, pleural disorders (e.g., pleurisy, pleural effusion, and pneumothorax (e.g., simple spontaneous pneumothorax, complicated spontaneous pneumothorax, tension pneumothorax)), obstructive airway diseases (e.g., asthma, chronic obstructive pulmonary disease (COPD), emphysema, chronic or acute bronchitis), occupational lung diseases (e.g., silicosis, black lung (coal workers' pneumoconiosis), asbestosis, berylliosis, occupational asthsma, byssinosis, and benign pneumoconioses), Infiltrative Lung Disease (e.g., pulmonary fibrosis (e.g., fibrosing alveolitis, usual interstitial pneumonia), idiopathic pulmonary fibrosis, desquamative interstitial pneumonia, lymphoid interstitial pneumonia, histiocytosis X (e.g., Letterer-Siwe disease, Hand-Schüller-Christian disease, eosinophilic granuloma), idiopathic pulmonary hemosiderosis, sarcoidosis and pulmonary alveolar proteinosis), Acute respiratory distress syndrome (also called, e.g., adult respiratory distress syndrome), edema, pulmonary embolism, bronchitis (e.g., viral, bacterial), bronchiectasis, atelectasis, lung abscess (caused by, e.g., Staphylococcus aureus or Legionella pneumophila), and cystic fibrosis.

[0709] Anti-Angiogenesis Activity

[0710] The naturally occurring balance between endogenous stimulators and inhibitors of angiogenesis is one in which inhibitory influences predominate. Rastinejad et al., Cell 56:345-355 (1989). In those rare instances in which neovascularization occurs under normal physiological conditions, such as wound healing, organ regeneration, embryonic development, and female reproductive processes, angiogenesis is stringently regulated and spatially and temporally delimited. Under conditions of pathological angiogenesis such as that characterizing solid tumor growth, these regulatory controls fail. Unregulated angiogenesis becomes pathologic and sustains progression of many neoplastic and non-neoplastic diseases. A number of serious diseases are dominated by abnormal neovascularization including solid tumor growth and metastases, arthritis, some types of eye disorders, and psoriasis. See, e.g., reviews by Moses et al., Biotech. 9:630-634 (1991); Folkman et al., N. Engl. J Med., 333:1757-1763 (1995); Auerbach et al., J. Microvasc. Res. 29:401-411 (1985); Folkman, Advances in Cancer Research, eds. Klein and Weinhouse, Academic Press, New York, pp. 175-203 (1985); Patz, Am. J Opthalmol. 94:715-743 (1982); and Folkman et al., Science 221:719-725 (1983). In a number of pathological conditions, the process of angiogenesis contributes to the disease state. For example, significant data have accumulated which suggest that the growth of solid tumors is dependent on angiogenesis. Folkman and Klagsbrun, Science 235:442-447 (1987).

[0711] The present invention provides for treatment of diseases or disorders associated with neovascularization by administration of the polynucleotides and/or polypeptides of the invention, as well as agonists or antagonists of the present invention. Malignant and metastatic conditions which can be treated with the polynucleotides and polypeptides, or agonists or antagonists of the invention include, but are not limited to, malignancies, solid tumors, and cancers described herein and otherwise known in the art (for a review of such disorders, see Fishman et al., Medicine, 2d Ed., J. B. Lippincott Co., Philadelphia (1985)). Thus, the present invention provides a method of treating an angiogenesis-related disease and/or disorder, comprising administration to an individual in need thereof a therapeutically effective amount of a polynucleotide, polypeptide, antagonist and/or agonist of the invention. For example, polynucleotides, polypeptides, antagonists and/or agonists may be utilized in a variety of additional methods in order to therapeutically treat a cancer or tumor. Cancers which may be treated with polynucleotides, polypeptides, antagonists and/or agonists include, but are not limited to solid tumors, including prostate, lung, breast, ovarian, stomach, pancreas, larynx, esophagus, testes, liver, parotid, biliary tract, colon, rectum, cervix, uterus, endometrium, kidney, bladder, thyroid cancer; primary tumors and metastases; melanomas; glioblastoma; Kaposi's sarcoma; leiomyosarcoma; non- small cell lung cancer; colorectal cancer; advanced malignancies; and blood born tumors such as leukemias. For example, polynucleotides, polypeptides, antagonists and/or agonists may be delivered topically, in order to treat cancers such as skin cancer, head and neck tumors, breast tumors, and Kaposi's sarcoma.

[0712] Within yet other aspects, polynucleotides, polypeptides, antagonists and/or agonists may be utilized to treat superficial forms of bladder cancer by, for example, intravesical administration. Polynucleotides, polypeptides, antagonists and/or agonists may be delivered directly into the tumor, or near the tumor site, via injection or a catheter. Of course, as the artisan of ordinary skill will appreciate, the appropriate mode of administration will vary according to the cancer to be treated. Other modes of delivery are discussed herein.

[0713] Polynucleotides, polypeptides, antagonists and/or agonists may be useful in treating other disorders, besides cancers, which involve angiogenesis. These disorders include, but are not limited to: benign tumors, for example hemangiomas, acoustic neuromas, neurofibromas, trachomas, and pyogenic granulomas; artheroscleric plaques; ocular angiogenic diseases, for example, diabetic retinopathy, retinopathy of prematurity, macular degeneration, comeal graft rejection, neovascular glaucoma, retrolental fibroplasia, rubeosis, retinoblastoma, uvietis and Pterygia (abnormal blood vessel growth) of the eye; rheumatoid arthritis; psoriasis; delayed wound healing; endometriosis; vasculogenesis; granulations; hypertrophic scars (keloids); nonunion fractures; scleroderma; trachoma; vascular adhesions; myocardial angiogenesis; coronary collaterals; cerebral collaterals; arteriovenous malformations; ischemic limb angiogenesis; Osler-Webber Syndrome; plaque neovascularization; telangiectasia; hemophiliac joints; angiofibroma; fibromuscular dysplasia; wound granulation; Crohn's disease; and atherosclerosis.

[0714] For example, within one aspect of the present invention methods are provided for treating hypertrophic scars and keloids, comprising the step of administering a polynucleotide, polypeptide, antagonist and/or agonist of the invention to a hypertrophic scar or keloid.

[0715] Within one embodiment of the present invention polynucleotides, polypeptides, antagonists and/or agonists of the invention are directly injected into a hypertrophic scar or keloid, in order to prevent the progression of these lesions. This therapy is of particular value in the prophylactic treatment of conditions which are known to result in the development of hypertrophic scars and keloids (e.g., burns), and is preferably initiated after the proliferative phase has had time to progress (approximately 14 days after the initial injury), but before hypertrophic scar or keloid development. As noted above, the present invention also provides methods for treating neovascular diseases of the eye, including for example, corneal neovascularization, neovascular glaucoma, proliferative diabetic retinopathy, retrolental fibroplasia and macular degeneration.

[0716] Moreover, ocular disorders associated with neovascularization which can be treated with the polynucleotides and polypeptides of the present invention (including agonists and/or antagonists) include, but are not limited to: neovascular glaucoma, diabetic retinopathy, retinoblastoma, retrolental fibroplasia, uveitis, retinopathy of prematurity macular degeneration, corneal graft neovascularization, as well as other eye inflammatory diseases, ocular tumors and diseases associated with choroidal or iris neovascularization. See, e.g., reviews by Waltman et al., Am. J Ophthal 85:704-710 (1978) and Gartner et al., Surv. Ophthal. 22:291-312 (1978).

[0717] Thus, within one aspect of the present invention methods are provided for treating neovascular diseases of the eye such as corneal neovascularization (including corneal graft neovascularization), comprising the step of administering to a patient a therapeutically effective amount of a compound (as described above) to the cornea, such that the formation of blood vessels is inhibited. Briefly, the cornea is a tissue, which normally lacks blood vessels. In certain pathological conditions however, capillaries may extend into the cornea from the pericorneal vascular plexus of the limbus. When the cornea becomes vascularized, it also becomes clouded, resulting in a decline in the patient's visual acuity. Visual loss may become complete if the cornea completely opacitates. A wide variety of disorders can result in corneal neovascularization, including for example, corneal infections (e.g., trachoma, herpes simplex keratitis, leishmaniasis and onchocerciasis), immunological processes (e.g., graft rejection and Stevens-Johnson's syndrome), alkali burns, trauma, inflammation (of any cause), toxic and nutritional deficiency states, and as a complication of wearing contact lenses.

[0718] Within particularly preferred embodiments of the invention, may be prepared for topical administration in saline (combined with any of the preservatives and antimicrobial agents commonly used in ocular preparations), and administered in eyedrop form. The solution or suspension may be prepared in its pure form and administered several times daily. Alternatively, anti-angiogenic compositions, prepared as described above, may also be administered directly to the cornea. Within preferred embodiments, the anti-angiogenic composition is prepared with a muco-adhesive polymer, which binds to cornea. Within further embodiments, the anti-angiogenic factors or anti-angiogenic compositions may be utilized as an adjunct to conventional steroid therapy. Topical therapy may also be useful prophylactically in corneal lesions which are known to have a high probability of inducing an angiogenic response (such as chemical bums). In these instances the treatment, likely in combination with steroids, may be instituted immediately to help prevent subsequent complications.

[0719] Within other embodiments, the compounds described above may be injected directly into the corneal stroma by an ophthalmologist under microscopic guidance. The preferred site of injection may vary with the morphology of the individual lesion, but the goal of the administration would be to place the composition at the advancing front of the vasculature (i.e., interspersed between the blood vessels and the normal cornea). In most cases this would involve perilimbic comeal injection to “protect” the cornea from the advancing blood vessels. This method may also be utilized shortly after a corneal insult in order to prophylactically prevent corneal neovascularization. In this situation, the material could be injected in the perilimbic cornea interspersed between the corneal lesion and its undesired potential limbic blood supply. Such methods may also be utilized in a similar fashion to prevent capillary invasion of transplanted corneas. In a sustained-release form, injections might only be required 2-3 times per year. A steroid could also be added to the injection solution to reduce inflammation resulting from the injection itself.

[0720] Within another aspect of the present invention, methods are provided for treating neovascular glaucoma, comprising the step of administering to a patient a therapeutically effective amount of a polynucleotide, polypeptide, antagonist and/or agonist to the eye, such that the formation of blood vessels is inhibited. In one embodiment, the compound may be administered topically to the eye in order to treat early forms of neovascular glaucoma. Within other embodiments, the compound may be implanted by injection into the region of the anterior chamber angle. Within other embodiments, the compound may also be placed in any location such that the compound is continuously released into the aqueous humor. Within another aspect of the present invention, methods are provided for treating proliferative diabetic retinopathy, comprising the step of administering to a patient a therapeutically effective amount of a polynucleotide, polypeptide, antagonist and/or agonist to the eyes, such that the formation of blood vessels is inhibited.

[0721] Within particularly preferred embodiments of the invention, proliferative diabetic retinopathy may be treated by injection into the aqueous humor or the vitreous, in order to increase the local concentration of the polynucleotide, polypeptide, antagonist and/or agonist in the retina. Preferably, this treatment should be initiated prior to the acquisition of severe disease requiring photocoagulation.

[0722] Within another aspect of the present invention, methods are provided for treating retrolental fibroplasia, comprising the step of administering to a patient a therapeutically effective amount of a polynucleotide, polypeptide, antagonist and/or agonist to the eye, such that the formation of blood vessels is inhibited. The compound may be administered topically, via intravitreous injection and/or via intraocular implants.

[0723] Additionally, disorders which can be treated with the polynucleotides, polypeptides, agonists and/or agonists include, but are not limited to, hemangioma, arthritis, psoriasis, angiofibroma, atherosclerotic plaques, delayed wound healing, granulations, hemophilic joints, hypertrophic scars, nonunion fractures, Osler-Weber syndrome, pyogenic granuloma, scleroderma, trachoma, and vascular adhesions.

[0724] Moreover, disorders and/or states, which can be treated, prevented, diagnosed and/or prognosed with the polynucleotides, polypeptides, agonists and/or agonists of the invention include, but are not limited to, solid tumors, blood born tumors such as leukemias, tumor metastasis, Kaposi's sarcoma, benign tumors, for example hemangiomas, acoustic neuromas, neurofibromas, trachomas, and pyogenic granulomas, rheumatoid arthritis, psoriasis, ocular angiogenic diseases, for example, diabetic retinopathy, retinopathy of prematurity, macular degeneration, corneal graft rejection, neovascular glaucoma, retrolental fibroplasia, rubeosis, retinoblastoma, and uvietis, delayed wound healing, endometriosis, vascluogenesis, granulations, hypertrophic scars (keloids), nonunion fractures, scleroderma, trachoma, vascular adhesions, myocardial angiogenesis, coronary collaterals, cerebral collaterals, arteriovenous malformations, ischemic limb angiogenesis, Osler-Webber Syndrome, plaque neovascularization, telangiectasia, hemophiliac joints, angiofibroma fibromuscular dysplasia, wound granulation, Crohn's disease, atherosclerosis, birth control agent by preventing vascularization required for embryo implantation controlling menstruation, diseases that have angiogenesis as a pathologic consequence such as cat scratch disease (Rochele minalia quintosa), ulcers (Helicobacter pylori), Bartonellosis and bacillary angiomatosis.

[0725] In one aspect of the birth control method, an amount of the compound sufficient to block embryo implantation is administered before or after intercourse and fertilization have occurred, thus providing an effective method of birth control, possibly a “morning after” method. Polynucleotides, polypeptides, agonists and/or agonists may also be used in controlling menstruation or administered as either a peritoneal lavage fluid or for peritoneal implantation in the treatment of endometriosis.

[0726] Polynucleotides, polypeptides, agonists and/or agonists of the present invention may be incorporated into surgical sutures in order to prevent stitch granulomas.

[0727] Polynucleotides, polypeptides, agonists and/or agonists may be utilized in a wide variety of surgical procedures. For example, within one aspect of the present invention a compositions (in the form of, for example, a spray or film) may be utilized to coat or spray an area prior to removal of a tumor, in order to isolate normal surrounding tissues from malignant tissue, and/or to prevent the spread of disease to surrounding tissues. Within other aspects of the present invention, compositions (e.g., in the form of a spray) may be delivered via endoscopic procedures in order to coat tumors, or inhibit angiogenesis in a desired locale. Within yet other aspects of the present invention, surgical meshes, which have been coated with anti- angiogenic compositions of the present invention may be utilized in any procedure wherein a surgical mesh might be utilized. For example, within one embodiment of the invention a surgical mesh laden with an anti-angiogenic composition may be utilized during abdominal cancer resection surgery (e.g., subsequent to colon resection) in order to provide support to the structure, and to release an amount of the anti-angiogenic factor.

[0728] Within further aspects of the present invention, methods are provided for treating tumor excision sites, comprising administering a polynucleotide, polypeptide, agonist and/or agonist to the resection margins of a tumor subsequent to excision, such that the local recurrence of cancer and the formation of new blood vessels at the site is inhibited. Within one embodiment of the invention, the anti-angiogenic compound is administered directly to the tumor excision site (e.g., applied by swabbing, brushing or otherwise coating the resection margins of the tumor with the anti-angiogenic compound). Alternatively, the anti-angiogenic compounds may be incorporated into known surgical pastes prior to administration. Within particularly preferred embodiments of the invention, the anti-angiogenic compounds are applied after hepatic resections for malignancy, and after neurosurgical operations.

[0729] Within one aspect of the present invention, polynucleotides, polypeptides, agonists and/or agonists may be administered to the resection margin of a wide variety of tumors, including for example, breast, colon, brain and hepatic tumors. For example, within one embodiment of the invention, anti-angiogenic compounds may be administered to the site of a neurological tumor subsequent to excision, such that the formation of new blood vessels at the site are inhibited.

[0730] The polynucleotides, polypeptides, agonists and/or agonists of the present invention may also be administered along with other anti-angiogenic factors. Representative examples of other anti-angiogenic factors include: Anti-Invasive Factor, retinoic acid and derivatives thereof, paclitaxel, Suramin, Tissue Inhibitor of Metalloproteinase-1, Tissue Inhibitor of Metalloproteinase-2, Plasminogen Activator Inhibitor-1, Plasminogen Activator Inhibitor-2, and various forms of the lighter “d group” transition metals.

[0731] Lighter “d group” transition metals include, for example, vanadium, molybdenum, tungsten, titanium, niobium, and tantalum species. Such transition metal species may form transition metal complexes. Suitable complexes of the above-mentioned transition metal species include oxo transition metal complexes.

[0732] Representative examples of vanadium complexes include oxo vanadium complexes such as vanadate and vanadyl complexes. Suitable vanadate complexes include metavanadate and orthovanadate complexes such as, for example, ammonium metavanadate, sodium metavanadate, and sodium orthovanadate. Suitable vanadyl complexes include, for example, vanadyl acetylacetonate and vanadyl sulfate including vanadyl sulfate hydrates such as vanadyl sulfate mono- and trihydrates.

[0733] Representative examples of tungsten and molybdenum complexes also include oxo complexes. Suitable oxo tungsten complexes include tungstate and tungsten oxide complexes. Suitable tungstate complexes include ammonium tungstate, calcium tungstate, sodium tungstate dihydrate, and tungstic acid. Suitable tungsten oxides include tungsten (IV) oxide and tungsten (VI) oxide. Suitable oxo molybdenum complexes include molybdate, molybdenum oxide, and molybdenyl complexes. Suitable molybdate complexes include ammonium molybdate and its hydrates, sodium molybdate and its hydrates, and potassium molybdate and its hydrates. Suitable molybdenum oxides include molybdenum (VI) oxide, molybdenum (VI) oxide, and molybdic acid. Suitable molybdenyl complexes include, for example, molybdenyl acetylacetonate. Other suitable tungsten and molybdenum complexes include hydroxo derivatives derived from, for example, glycerol, tartaric acid, and sugars.

[0734] A wide variety of other anti-angiogenic factors may also be utilized within the context of the present invention. Representative examples include platelet factor 4; protamine sulphate; sulphated chitin derivatives (prepared from queen crab shells), (Murata et al., Cancer Res. 51:22-26 (1991)); Sulphated Polysaccharide Peptidoglycan Complex (SP- PG) (the function of this compound may be enhanced by the presence of steroids such as estrogen, and tamoxifen citrate); Staurosporine; modulators of matrix metabolism, including for example, proline analogs, cishydroxyproline, d,L-3,4-dehydroproline, Thiaproline, alpha,alpha-dipyridyl, aminopropionitrile fumarate; 4-propyl-5-(4-pyridinyl)-2(3H)-oxazolone; Methotrexate; Mitoxantrone; Heparin; Interferons; 2 Macroglobulin-serum; ChIMP-3 (Pavloff et al., J. Bio. Chem. 267:17321-17326 (1992)); Chymostatin (Tomkinson et al., Biochem J. 286:475-480 (1992)); Cyclodextrin Tetradecasulfate; Eponemycin; Camptothecin; Fumagillin (Ingber et al., Nature 348:555-557 (1990)); Gold Sodium Thiomalate (“GST”; Matsubara and Ziff, J. Clin. Invest. 79:1440-1446 (1987)); anticollagenase-serum; alpha2-antiplasmin (Holmes et al., J. Biol. Chem. 262(4):1659-1664 (1987)); Bisantrene (National Cancer Institute); Lobenzarit disodium (N-(2)-carboxyphenyl-4-chloroanthronilic acid disodium or “CCA”; Takeuchi et al., Agents Actions 36:312-316, 1992); Thalidomide; Angostatic steroid; AGM-1470; carboxynaminolmidazole; and metalloproteinase inhibitors such as BB94.

[0735] Musculoskeletal System Disorders

[0736] Polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention, may be used to treat, prevent, diagnose, and/or prognose disorders of the musculoskeletal system, including but not limited to, disorders of the bone, joints, ligaments, tendons, bursa, muscle, and/or neoplasms and cancers associated with musculoskeletal tissue.

[0737] Diseases or disorders of the bone include, but are not limited to, Albers-Schönberg disease, bowlegs, heel spurs, Kohler's bone disease, knock-knees, Legg-Calvé-Perthes disease, Marfan's syndrome, mucopolysaccharidoses, Osgood-Schlatter disease, osteochondroses, osteochondrodysplasia, osteomyelitis, osteopetroses, osteoporosis (postmenopausal, senile, and juvenile), Paget's disease, Scheuermann's disease, scoliosis, Sever's disease, and patellofemoral stress syndrome.

[0738] Joint diseases or disorders include, but are not limited to, ankylosing spondylitis, Behcet's syndrome, CREST syndrome, Ehlers-Danlos syndrome, infectious arthritis, discoid lupus erythematosus, systemic lupus erythematosus, Lyme disease, osteoarthritis, psoriatic arthritis, relapsing polychondrites, Reiter's syndrome, rheumatoid arthritis (adult and juvenile), scleroderma, and Still's disease.

[0739] Diseases or disorders affecting ligaments, tendons, or bursa include, but are not limited to, ankle sprain, bursitis, posterior Achilles tendon bursitis (Haglund's deformity), anterior Achilles tendon bursitis (Albert's disease), tendinitis, tenosynovitis, poplieus tendinitis, Achilles tendinitis, medial or lateral epicondylitis, rotator cuff tendinitis, spasmodic torticollis, and fibromyalgia syndrome.

[0740] Muscle diseases or disorders include, but are not limited to, Becker's muscular dystrophy, Duchenne's muscular dystrophy, Landouzy-Dejerine muscular dystrophy, Leyden-Möbius muscular dystrophy, Erb's muscular dystrophy, Charcot's joints, dermatomyositis, gout, pseudogout, glycogen storage diseases, Pompe's disease, mitochondrial myopathy, periodic paralysis, polymyalgia rheumatica, polymyositis, Steinert's disease, Thomsen's disease, anterolateral and posteromedial shin splints, posterior femoral muscle strain, and fibromyositis.

[0741] Musculoskeletal tissue may also develop cancers and/or neoplasms that include, but are not limited to, osteochondroma, benign chondroma, chondroblastoma, chondromyxoid fibroma, osteoid osteoma, giant cell tumor, multiple myeloma, osteosarcoma, fibrosarcoma, malignant fibrous histiocytoma, chondrosarcoma, Ewing's tumor, and malignant lymphoma of bone.

[0742] Neural Activity and Neurological Diseases

[0743] The polynucleotides, polypeptides and agonists or antagonists of the invention may be used for the diagnosis and/or treatment of diseases, disorders, damage or injury of the brain and/or nervous system. Nervous system disorders that can be treated with the compositions of the invention (e.g., polypeptides, polynucleotides, and/or agonists or antagonists), include, but are not limited to, nervous system injuries, and diseases or disorders which result in either a disconnection of axons, a diminution or degeneration of neurons, or demyelination. Nervous system lesions which may be treated in a patient (including human and non-human mammalian patients) according to the methods of the invention, include but are not limited to, the following lesions of either the central (including spinal cord, brain) or peripheral nervous systems: (1) ischemic lesions, in which a lack of oxygen in a portion of the nervous system results in neuronal injury or death, including cerebral infarction or ischemia, or spinal cord infarction or ischemia; (2) traumatic lesions, including lesions caused by physical injury or associated with surgery, for example, lesions which sever a portion of the nervous system, or compression injuries; (3) malignant lesions, in which a portion of the nervous system is destroyed or injured by malignant tissue which is either a nervous system associated malignancy or a malignancy derived from non-nervous system tissue; (4) infectious lesions, in which a portion of the nervous system is destroyed or injured as a result of infection, for example, by an abscess or associated with infection by human immunodeficiency virus, herpes zoster, or herpes simplex virus or with Lyme disease, tuberculosis, or syphilis; (5) degenerative lesions, in which a portion of the nervous system is destroyed or injured as a result of a degenerative process including but not limited to, degeneration associated with Parkinson's disease, Alzheimer's disease, Huntington's chorea, or amyotrophic lateral sclerosis (ALS); (6) lesions associated with nutritional diseases or disorders, in which a portion of the nervous system is destroyed or injured by a nutritional disorder or disorder of metabolism including, but not limited to, vitamin B12 deficiency, folic acid deficiency, Wemicke disease, tobacco-alcohol amblyopia, Marchiafava-Bignami disease (primary degeneration of the corpus callosum), and alcoholic cerebellar degeneration; (7) neurological lesions associated with systemic diseases including, but not limited to, diabetes (diabetic neuropathy, Bell's palsy), systemic lupus erythematosus, carcinoma, or sarcoidosis; (8) lesions caused by toxic substances including alcohol, lead, or particular neurotoxins; and (9) demyelinated lesions in which a portion of the nervous system is destroyed or injured by a demyelinating disease including, but not limited to, multiple sclerosis, human immunodeficiency virus-associated myelopathy, transverse myelopathy or various etiologies, progressive multifocal leukoencephalopathy, and central pontine myelinolysis.

[0744] In one embodiment, the polypeptides, polynucleotides, or agonists or antagonists of the invention are used to protect neural cells from the damaging effects of hypoxia. In a further preferred embodiment, the polypeptides, polynucleotides, or agonists or antagonists of the invention are used to protect neural cells from the damaging effects of cerebral hypoxia. According to this embodiment, the compositions of the invention are used to treat or prevent neural cell injury associated with cerebral hypoxia. In one non-exclusive aspect of this embodiment, the polypeptides, polynucleotides, or agonists or antagonists of the invention, are used to treat or prevent neural cell injury associated with cerebral ischemia. In another non-exclusive aspect of this embodiment, the polypeptides, polynucleotides, or agonists or antagonists of the invention are used to treat or prevent neural cell injury associated with cerebral infarction.

[0745] In another preferred embodiment, the polypeptides, polynucleotides, or agonists or antagonists of the invention are used to treat or prevent neural cell injury associated with a stroke. In a specific embodiment, the polypeptides, polynucleotides, or agonists or antagonists of the invention are used to treat or prevent cerebral neural cell injury associated with a stroke.

[0746] In another preferred embodiment, the polypeptides, polynucleotides, or agonists or antagonists of the invention are used to treat or prevent neural cell injury associated with a heart attack. In a specific embodiment, the polypeptides, polynucleotides, or agonists or antagonists of the invention are used to treat or prevent cerebral neural cell injury associated with a heart attack.

[0747] The compositions of the invention which are useful for treating or preventing a nervous system disorder may be selected by testing for biological activity in promoting the survival or differentiation of neurons. For example, and not by way of limitation, compositions of the invention which elicit any of the following effects may be useful according to the invention: (1) increased survival time of neurons in culture either in the presence or absence of hypoxia or hypoxic conditions; (2) increased sprouting of neurons in culture or in vivo; (3) increased production of a neuron-associated molecule in culture or in vivo, e.g., choline acetyltransferase or acetylcholinesterase with respect to motor neurons; or (4) decreased symptoms of neuron dysfunction in vivo. Such effects may be measured by any method known in the art. In preferred, non-limiting embodiments, increased survival of neurons may routinely be measured using a method set forth herein or otherwise known in the art, such as, for example, in Zhang et al., Proc Natl Acad Sci USA 97:3637-42 (2000) or in Arakawa et al., J. Neurosci., 10:3507-15 (1990); increased sprouting of neurons may be detected by methods known in the art, such as, for example, the methods set forth in Pestronk et al., Exp. Neurol., 70:65-82 (1980), or Brown et al., Ann. Rev. Neurosci., 4:17-42 (1981); increased production of neuron-associated molecules may be measured by bioassay, enzymatic assay, antibody binding, Northern blot assay, etc., using techniques known in the art and depending on the molecule to be measured; and motor neuron dysfunction may be measured by assessing the physical manifestation of motor neuron disorder, e.g., weakness, motor neuron conduction velocity, or functional disability.

[0748] In specific embodiments, motor neuron disorders that may be treated according to the invention include, but are not limited to, disorders such as infarction, infection, exposure to toxin, trauma, surgical damage, degenerative disease or malignancy that may affect motor neurons as well as other components of the nervous system, as well as disorders that selectively affect neurons such as amyotrophic lateral sclerosis, and including, but not limited to, progressive spinal muscular atrophy, progressive bulbar palsy, primary lateral sclerosis, infantile and juvenile muscular atrophy, progressive bulbar paralysis of childhood (Fazio-Londe syndrome), poliomyelitis and the post polio syndrome, and Hereditary Motorsensory Neuropathy (Charcot-Marie-Tooth Disease).

[0749] Further, polypeptides or polynucleotides of the invention may play a role in neuronal survival; synapse formation; conductance; neural differentiation, etc. Thus, compositions of the invention (including polynucleotides, polypeptides, and agonists or antagonists) may be used to diagnose and/or treat or prevent diseases or disorders associated with these roles, including, but not limited to, learning and/or cognition disorders. The compositions of the invention may also be useful in the treatment or prevention of neurodegenerative disease states and/or behavioural disorders. Such neurodegenerative disease states and/or behavioral disorders include, but are not limited to, Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, Tourette Syndrome, schizophrenia, mania, dementia, paranoia, obsessive compulsive disorder, panic disorder, learning disabilities, ALS, psychoses, autism, and altered behaviors, including disorders in feeding, sleep patterns, balance, and perception. In addition, compositions of the invention may also play a role in the treatment, prevention and/or detection of developmental disorders associated with the developing embryo, or sexually-linked disorders.

[0750] Additionally, polypeptides, polynucleotides and/or agonists or antagonists of the invention, may be useful in protecting neural cells from diseases, damage, disorders, or injury, associated with cerebrovascular disorders including, but not limited to, carotid artery diseases (e.g., carotid artery thrombosis, carotid stenosis, or Moyamoya Disease), cerebral amyloid angiopathy, cerebral aneurysm, cerebral anoxia, cerebral arteriosclerosis, cerebral arteriovenous malformations, cerebral artery diseases, cerebral embolism and thrombosis (e.g., carotid artery thrombosis, sinus thrombosis, or Wallenberg's Syndrome), cerebral hemorrhage (e.g., epidural or subdural hematoma, or subarachnoid hemorrhage), cerebral infarction, cerebral ischemia (e.g., transient cerebral ischemia, Subclavian Steal Syndrome, or vertebrobasilar insufficiency), vascular dementia (e.g., multi-infarct), leukomalacia, periventricular, and vascular headache (e.g., cluster headache or migraines).

[0751] In accordance with yet a further aspect of the present invention, there is provided a process for utilizing polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, for therapeutic purposes, for example, to stimulate neurological cell proliferation and/or differentiation. Therefore, polynucleotides, polypeptides, agonists and/or antagonists of the invention may be used to treat and/or detect neurologic diseases. Moreover, polynucleotides or polypeptides, or agonists or antagonists of the invention, can be used as a marker or detector of a particular nervous system disease or disorder.

[0752] Examples of neurologic diseases which can be treated or detected with polynucleotides, polypeptides, agonists, and/or antagonists of the present invention include brain diseases, such as metabolic brain diseases which includes phenylketonuria such as maternal phenylketonuria, pyruvate carboxylase deficiency, pyruvate dehydrogenase complex deficiency, Wernicke's Encephalopathy, brain edema, brain neoplasms such as cerebellar neoplasms which include infratentorial neoplasms, cerebral ventricle neoplasms such as choroid plexus neoplasms, hypothalamic neoplasms, supratentorial neoplasms, canavan disease, cerebellar diseases such as cerebellar ataxia which include spinocerebellar degeneration such as ataxia telangiectasia, cerebellar dyssynergia, Friederich's Ataxia, Machado-Joseph Disease, olivopontocerebellar atrophy, cerebellar neoplasms such as infratentorial neoplasms, diffuse cerebral sclerosis such as encephalitis periaxialis, globoid cell leukodystrophy, metachromatic leukodystrophy and subacute sclerosing panencephalitis.

[0753] Additional neurologic diseases which can be treated or detected with polynucleotides, polypeptides, agonists, and/or antagonists of the present invention include cerebrovascular disorders (such as carotid artery diseases which include carotid artery thrombosis, carotid stenosis and Moyamoya Disease), cerebral amyloid angiopathy, cerebral aneurysm, cerebral anoxia, cerebral arteriosclerosis, cerebral arteriovenous malformations, cerebral artery diseases, cerebral embolism and thrombosis such as carotid artery thrombosis, sinus thrombosis and Wallenberg's Syndrome, cerebral hemorrhage such as epidural hematoma, subdural hematoma and subarachnoid hemorrhage, cerebral infarction, cerebral ischemia such as transient cerebral ischemia, Subclavian Steal Syndrome and vertebrobasilar insufficiency, vascular dementia such as multi-infarct dementia, periventricular leukomalacia, vascular headache such as cluster headache and migraine.

[0754] Additional neurologic diseases which can be treated or detected with polynucleotides, polypeptides, agonists, and/or antagonists of the present invention include dementia such as AIDS Dementia Complex, presenile dementia such as Alzheimer's Disease and Creutzfeldt-Jakob Syndrome, senile dementia such as Alzheimer's Disease and progressive supranuclear palsy, vascular dementia such as multi-infarct dementia, encephalitis which include encephalitis periaxialis, viral encephalitis such as epidemic encephalitis, Japanese Encephalitis, St. Louis Encephalitis, tick-borne encephalitis and West Nile Fever, acute disseminated encephalomyelitis, meningoencephalitis such as uveomeningoencephalitic syndrome, Postencephalitic Parkinson Disease and subacute sclerosing panencephalitis, encephalomalacia such as periventricular leukomalacia, epilepsy such as generalized epilepsy which includes infantile spasms, absence epilepsy, myoclonic epilepsy which includes MERRF Syndrome, tonic-clonic epilepsy, partial epilepsy such as complex partial epilepsy, frontal lobe epilepsy and temporal lobe epilepsy, post-traumatic epilepsy, status epilepticus such as Epilepsia Partialis Continua, and Hallervorden-Spatz Syndrome.

[0755] Additional neurologic diseases which can be treated or detected with polynucleotides, polypeptides, agonists, and/or antagonists of the present invention include hydrocephalus such as Dandy-Walker Syndrome and normal pressure hydrocephalus, hypothalamic diseases such as hypothalamic neoplasms, cerebral malaria, narcolepsy which includes cataplexy, bulbar poliomyelitis, cerebri pseudotumor, Rett Syndrome, Reye's Syndrome, thalamic diseases, cerebral toxoplasmosis, intracranial tuberculoma and Zellweger Syndrome, central nervous system infections such as AIDS Dementia Complex, Brain Abscess, subdural empyema, encephalomyelitis such as Equine Encephalomyelitis, Venezuelan Equine Encephalomyelitis, Necrotizing Hemorrhagic Encephalomyelitis, Visna, and cerebral malaria.

[0756] Additional neurologic diseases which can be treated or detected with polynucleotides, polypeptides, agonists, and/or antagonists of the present invention include meningitis such as arachnoiditis, aseptic meningtitis such as viral meningtitis which includes lymphocytic choriomeningitis, Bacterial meningtitis which includes Haemophilus Meningtitis, Listeria Meningtitis, Meningococcal Meningtitis such as Waterhouse-Friderichsen Syndrome, Pneumococcal Meningtitis and meningeal tuberculosis, fungal meningitis such as Cryptococcal Meningtitis, subdural effusion, meningoencephalitis such as uvemeningoencephalitic syndrome, myelitis such as transverse myelitis, neurosyphilis such as tabes dorsalis, poliomyelitis which includes bulbar poliomyelitis and postpoliomyelitis syndrome, prion diseases (such as Creutzfeldt-Jakob Syndrome, Bovine Spongiform Encephalopathy, Gerstmann-Straussler Syndrome, Kuru, Scrapie), and cerebral toxoplasmosis.

[0757] Additional neurologic diseases which can be treated or detected with polynucleotides, polypeptides, agonists, and/or antagonists of the present invention include central nervous system neoplasms such as brain neoplasms that include cerebellar neoplasms such as infratentorial neoplasms, cerebral ventricle neoplasms such as choroid plexus neoplasms, hypothalamic neoplasms and supratentorial neoplasms, meningeal neoplasms, spinal cord neoplasms which include epidural neoplasms, demyelinating diseases such as Canavan Diseases, diffuse cerebral sceloris which includes adrenoleukodystrophy, encephalitis periaxialis, globoid cell leukodystrophy, diffuse cerebral sclerosis such as metachromatic leukodystrophy, allergic encephalomyelitis, necrotizing hemorrhagic encephalomyelitis, progressive multifocal leukoencephalopathy, multiple sclerosis, central pontine myelinolysis, transverse myelitis, neuromyclitis optica, Scrapie, Swayback, Chronic Fatigue Syndrome, Visna, High Pressure Nervous Syndrome, Meningism, spinal cord diseases such as amyotonia congenita, amyotrophic lateral sclerosis, spinal muscular atrophy such as Werdnig-Hoffmann Disease, spinal cord compression, spinal cord neoplasms such as epidural neoplasms, syringomyelia, Tabes Dorsalis, Stiff-Man Syndrome, mental retardation such as Angelman Syndrome, Cri-du-Chat Syndrome, De Lange's Syndrome, Down Syndrome, Gangliosidoses such as gangliosidoses G(M1), Sandhoff Disease, Tay-Sachs Disease, Hartnup Disease, homocystinuria, Laurence-Moon-Biedl Syndrome, Lesch-Nyhan Syndrome, Maple Syrup Urine Disease, mucolipidosis such as fucosidosis, neuronal ceroid-lipofuscinosis, oculocerebrorenal syndrome, phenylketonuria such as maternal phenylketonuria, Prader-Willi Syndrome, Rett Syndrome, Rubinstein-Taybi Syndrome, Tuberous Sclerosis, WAGR Syndrome, nervous system abnormalities such as holoprosencephaly, neural tube defects such as anencephaly which includes hydrangencephaly, Arnold-Chairi Deformity, encephalocele, meningocele, meningomyelocele, spinal dysraphism such as spina bifida cystica and spina bifida occulta.

[0758] Additional neurologic diseases which can be treated or detected with polynucleotides, polypeptides, agonists, and/or antagonists of the present invention include hereditary motor and sensory neuropathies which include Charcot-Marie Disease, Hereditary optic atrophy, Refsum's Disease, hereditary spastic paraplegia, Werdnig-Hoffmann Disease, Hereditary Sensory and Autonomic Neuropathies such as Congenital Analgesia and Familial Dysautonomia, Neurologic manifestations (such as agnosia that include Gerstmann's Syndrome, Amnesia such as retrograde amnesia, apraxia, neurogenic bladder, cataplexy, communicative disorders such as hearing disorders that includes deafness, partial hearing loss, loudness recruitment and tinnitus, language disorders such as aphasia which include agraphia, anomia, broca aphasia, and Wernicke Aphasia, Dyslexia such as Acquired Dyslexia, language development disorders, speech disorders such as aphasia which includes anomia, broca aphasia and Wernicke Aphasia, articulation disorders, communicative disorders such as speech disorders which include dysarthria, echolalia, mutism and stuttering, voice disorders such as aphonia and hoarseness, decerebrate state, delirium, fasciculation, hallucinations, meningism, movement disorders such as angelman syndrome, ataxia, athetosis, chorea, dystonia, hypokinesia, muscle hypotonia, myoclonus, tic, torticollis and tremor, muscle hypertonia such as muscle rigidity such as stiff-man syndrome, muscle spasticity, paralysis such as facial paralysis which includes Herpes Zoster Oticus, Gastroparesis, Hemiplegia, ophthalmoplegia such as diplopia, Duane's Syndrome, Homer's Syndrome, Chronic progressive external ophthalmoplegia such as Kearns Syndrome, Bulbar Paralysis, Tropical Spastic Paraparesis, Paraplegia such as Brown-Sequard Syndrome, quadriplegia, respiratory paralysis and vocal cord paralysis, paresis, phantom limb, taste disorders such as ageusia and dysgeusia, vision disorders such as amblyopia, blindness, color vision defects, diplopia, hemianopsia, scotoma and subnormal vision, sleep disorders such as hypersomnia which includes Kleine-Levin Syndrome, insomnia, and somnambulism, spasm such as trismus, unconsciousness such as coma, persistent vegetative state and syncope and vertigo, neuromuscular diseases such as amyotonia congenita, amyotrophic lateral sclerosis, Lambert-Eaton Myasthenic Syndrome, motor neuron disease, muscular atrophy such as spinal muscular atrophy, Charcot-Marie Disease and Werdnig-Hoffmann Disease, Postpoliomyelitis Syndrome, Muscular Dystrophy, Myasthenia Gravis, Myotonia Atrophica, Myotonia Confenita, Nemaline Myopathy, Familial Periodic Paralysis, Multiplex Paramyloclonus, Tropical Spastic Paraparesis and Stiff-Man Syndrome, peripheral nervous system diseases such as acrodynia, amyloid neuropathies, autonomic nervous system diseases such as Adie's Syndrome, Barre-Lieou Syndrome, Familial Dysautonomia, Homer's Syndrome, Reflex Sympathetic Dystrophy and Shy-Drager Syndrome, Cranial Nerve Diseases such as Acoustic Nerve Diseases such as Acoustic Neuroma which includes Neurofibromatosis 2, Facial Nerve Diseases such as Facial Neuralgia,Melkersson-Rosenthal Syndrome, ocular motility disorders which includes amblyopia, nystagmus, oculomotor nerve paralysis, ophthalmoplegia such as Duane's Syndrome, Homer's Syndrome, Chronic Progressive External Ophthalmoplegia which includes Kearns Syndrome, Strabismus such as Esotropia and Exotropia, Oculomotor Nerve Paralysis, Optic Nerve Diseases such as Optic Atrophy which includes Hereditary Optic Atrophy, Optic Disk Drusen, Optic Neuritis such as Neuromyelitis Optica, Papilledema, Trigeminal Neuralgia, Vocal Cord Paralysis, Demyelinating Diseases such as Neuromyelitis Optica and Swayback, and Diabetic neuropathies such as diabetic foot.

[0759] Additional neurologic diseases which can be treated or detected with polynucleotides, polypeptides, agonists, and/or antagonists of the present invention include nerve compression syndromes such as carpal tunnel syndrome, tarsal tunnel syndrome, thoracic outlet syndrome such as cervical rib syndrome, ulnar nerve compression syndrome, neuralgia such as causalgia, cervico-brachial neuralgia, facial neuralgia and trigeminal neuralgia, neuritis such as experimental allergic neuritis, optic neuritis, polyneuritis, polyradiculoneuritis and radiculities such as polyradiculitis, hereditary motor and sensory neuropathies such as Charcot-Marie Disease, Hereditary Optic Atrophy, Refsum's Disease, Hereditary Spastic Paraplegia and Werdnig-Hoffmann Disease, Hereditary Sensory and Autonomic Neuropathies which include Congenital Analgesia and Familial Dysautonomia, POEMS Syndrome, Sciatica, Gustatory Sweating and Tetany).

[0760] Endocrine Disorders

[0761] Polynucleotides or polypeptides, or agonists or antagonists of the present invention, may be used to treat, prevent, diagnose, and/or prognose disorders and/or diseases related to hormone imbalance, and/or disorders or diseases of the endocrine system.

[0762] Hormones secreted by the glands of the endocrine system control physical growth, sexual function, metabolism, and other functions. Disorders may be classified in two ways: disturbances in the production of hormones, and the inability of tissues to respond to hormones. The etiology of these hormone imbalance or endocrine system diseases, disorders or conditions may be genetic, somatic, such as cancer and some autoimmune diseases, acquired (e.g., by chemotherapy, injury or toxins), or infectious. Moreover, polynucleotides, polypeptides, antibodies, and/or agonists or antagonists of the present invention can be used as a marker or detector of a particular disease or disorder related to the endocrine system and/or hormone imbalance.

[0763] Endocrine system and/or hormone imbalance and/or diseases encompass disorders of uterine motility including, but not limited to: complications with pregnancy and labor (e.g., pre-term labor, post-term pregnancy, spontaneous abortion, and slow or stopped labor); and disorders and/or diseases of the menstrual cycle (e.g., dysmenorrhea and endometriosis).

[0764] Endocrine system and/or hormone imbalance disorders and/or diseases include disorders and/or diseases of the pancreas, such as, for example, diabetes mellitus, diabetes insipidus, congenital pancreatic agenesis, pheochromocytoma-islet cell tumor syndrome; disorders and/or diseases of the adrenal glands such as, for example, Addison's Disease, corticosteroid deficiency, virilizing disease, hirsutism, Cushing's Syndrome, hyperaldosteronism, pheochromocytoma; disorders and/or diseases of the pituitary gland, such as, for example, hyperpituitarism, hypopituitarism, pituitary dwarfism, pituitary adenoma, panhypopituitarism, acromegaly, gigantism; disorders and/or diseases of the thyroid, including but not limited to, hyperthyroidism, hypothyroidism, Plummer's disease, Graves' disease (toxic diffuse goiter), toxic nodular goiter, thyroiditis (Hashimoto's thyroiditis, subacute granulomatous thyroiditis, and silent lymphocytic thyroiditis), Pendred's syndrome, myxedema, cretinism, thyrotoxicosis, thyroid hormone coupling defect, thymic aplasia, Hurthle cell tumours of the thyroid, thyroid cancer, thyroid carcinoma, Medullary thyroid carcinoma; disorders and/or diseases of the parathyroid, such as, for example, hyperparathyroidism, hypoparathyroidism; disorders and/or diseases of the hypothalamus.

[0765] In addition, endocrine system and/or hormone imbalance disorders and/or diseases may also include disorders and/or diseases of the testes or ovaries, including cancer. Other disorders and/or diseases of the testes or ovaries further include, for example, ovarian cancer, polycystic ovary syndrome, Klinefelter's syndrome, vanishing testes syndrome (bilateral anorchia), congenital absence of Leydig's cells, cryptorchidism, Noonan's syndrome, myotonic dystrophy, capillary haemangioma of the testis (benign), neoplasias of the testis and neo-testis.

[0766] Moreover, endocrine system and/or hormone imbalance disorders and/or diseases may also include disorders and/or diseases such as, for example, polyglandular deficiency syndromes, pheochromocytoma, neuroblastoma, multiple Endocrine neoplasia, and disorders and/or cancers of endocrine tissues.

[0767] In another embodiment, a polypeptide of the invention, or polynucleotides, antibodies, agonists, or antagonists corresponding to that polypeptide, may be used to diagnose, prognose, prevent, and/or treat endocrine diseases and/or disorders associated with the tissue(s) in which the polypeptide of the invention is expressed, including one, two, three, four, five, or more tissues disclosed in Table 1A, column 7 (Tissue Distribution Library Code).

[0768] Gastrointestinal Disorders

[0769] Polynucleotides or polypeptides, or agonists or antagonists of the present invention, may be used to treat, prevent, diagnose, and/or prognose gastrointestinal disorders, including inflammatory diseases and/or conditions, infections, cancers (e.g., intestinal neoplasms (carcinoid tumor of the small intestine, non-Hodgkin's lymphoma of the small intestine, small bowl lymphoma)), and ulcers, such as peptic ulcers.

[0770] Gastrointestinal disorders include dysphagia, odynophagia, inflammation of the esophagus, peptic esophagitis, gastric reflux, submucosal fibrosis and stricturing, Mallory-Weiss lesions, leiomyomas, lipomas, epidermal cancers, adeoncarcinomas, gastric retention disorders, gastroenteritis, gastric atrophy, gastric/stomach cancers, polyps of the stomach, autoimmune disorders such as pernicious anemia, pyloric stenosis, gastritis (bacterial, viral, eosinophilic, stress-induced, chronic erosive, atrophic, plasma cell, and Ménétrier's), and peritoneal diseases (e.g., chyloperioneum, hemoperitoneum, mesenteric cyst, mesenteric lymphadenitis, mesenteric vascular occlusion, panniculitis, neoplasms, peritonitis, pneumoperitoneum, bubphrenic abscess).

[0771] Gastrointestinal disorders also include disorders associated with the small intestine, such as malabsorption syndromes, distension, irritable bowel syndrome, sugar intolerance, celiac disease, duodenal ulcers, duodenitis, tropical sprue, Whipple's disease, intestinal lymphangiectasia, Crohn's disease, appendicitis, obstructions of the ileum, Meckel's diverticulum, multiple diverticula, failure of complete rotation of the small and large intestine, lymphoma, and bacterial and parasitic diseases (such as Traveler's diarrhea, typhoid and paratyphoid, cholera, infection by Roundworms (Ascariasis lumbricoides), Hookworms (Ancylostoma duodenale), Threadworms (Enterobius vermicularis), Tapeworms (Taenia saginata, Echinococcus granulosus, Diphyllobothrium spp., and T. solium).

[0772] Liver diseases and/or disorders include intrahepatic cholestasis (alagille syndrome, biliary liver cirrhosis), fatty liver (alcoholic fatty liver, reye syndrome), hepatic vein thrombosis, hepatolentricular degeneration, hepatomegaly, hepatopulmonary syndrome, hepatorenal syndrome, portal hypertension (esophageal and gastric varices), liver abscess (amebic liver abscess), liver cirrhosis (alcoholic, biliary and experimental), alcoholic liver diseases (fatty liver, hepatitis, cirrhosis), parasitic (hepatic echinococcosis, fascioliasis, amebic liver abscess), jaundice (hemolytic, hepatocellular, and cholestatic), cholestasis, portal hypertension, liver enlargement, ascites, hepatitis (alcoholic hepatitis, animal hepatitis, chronic hepatitis (autoimmune, hepatitis B, hepatitis C, hepatitis D, drug induced), toxic hepatitis, viral human hepatitis (hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E), Wilson's disease, granulomatous hepatitis, secondary biliary cirrhosis, hepatic encephalopathy, portal hypertension, varices, hepatic encephalopathy, primary biliary cirrhosis, primary sclerosing cholangitis, hepatocellular adenoma, hemangiomas, bile stones, liver failure (hepatic encephalopathy, acute liver failure), and liver neoplasms (angiomyolipoma, calcified liver metastases, cystic liver metastases, epithelial tumors, fibrolamellar hepatocarcinoma, focal nodular hyperplasia, hepatic adenoma, hepatobiliary cystadenoma, hepatoblastoma, hepatocellular carcinoma, hepatoma, liver cancer, liver hemangioendothelioma, mesenchymal hamartoma, mesenchymal tumors of liver, nodular regenerative hyperplasia, benign liver tumors (Hepatic cysts [Simple cysts, Polycystic liver disease, Hepatobiliary cystadenoma, Choledochal cyst], Mesenchymal tumors [Mesenchymal hamartoma, Infantile hemangioendothelioma, Hemangioma, Peliosis hepatis, Lipomas, Inflammatory pseudotumor, Miscellaneous], Epithelial tumors [Bile duct epithelium (Bile duct hamartoma, Bile duct adenoma), Hepatocyte (Adenoma, Focal nodular hyperplasia, Nodular regenerative hyperplasia)], malignant liver tumors [hepatocellular, hepatoblastoma, hepatocellular carcinoma, cholangiocellular, cholangiocarcinoma, cystadenocarcinoma, tumors of blood vessels, angiosarcoma, Karposi's sarcoma, hemangioendothelioma, other tumors, embryonal sarcoma, fibrosarcoma, leiomyosarcoma, rhabdomyosarcoma, carcinosarcoma, teratoma, carcinoid, squamous carcinoma, primary lymphoma]), peliosis hepatis, erythrohepatic porphyria, hepatic porphyria (acute intermittent porphyria, porphyria cutanea tarda), Zellweger syndrome).

[0773] Pancreatic diseases and/or disorders include acute pancreatitis, chronic pancreatitis (acute necrotizing pancreatitis, alcoholic pancreatitis), neoplasms (adenocarcinoma of the pancreas, cystadenocarcinoma, insulinoma, gastrinoma, and glucagonoma, cystic neoplasms, islet-cell tumors, pancreoblastoma), and other pancreatic diseases (e.g., cystic fibrosis, cyst (pancreatic pseudocyst, pancreatic fistula, insufficiency)).

[0774] Gallbladder diseases include gallstones (cholelithiasis and choledocholithiasis), postcholecystectomy syndrome, diverticulosis of the gallbladder, acute cholecystitis, chronic cholecystitis, bile duct tumors, and mucocele.

[0775] Diseases and/or disorders of the large intestine include antibiotic-associated colitis, diverticulitis, ulcerative colitis, acquired megacolon, abscesses, fungal and bacterial infections, anorectal disorders (e.g., fissures, hemorrhoids), colonic diseases (colitis, colonic neoplasms [colon cancer, adenomatous colon polyps (e.g., villous adenoma), colon carcinoma, colorectal cancer], colonic diverticulitis, colonic diverticulosis, megacolon [Hirschsprung disease, toxic megacolon]; sigmoid diseases [proctocolitis, sigmoin neoplasms]), constipation, Crohn's disease, diarrhea (infantile diarrhea, dysentery), duodenal diseases (duodenal neoplasms, duodenal obstruction, duodenal ulcer, duodenitis), enteritis (enterocolitis), HIV enteropathy, ileal diseases (ileal neoplasms, ileitis), immunoproliferative small intestinal disease, inflammatory bowel disease (ulcerative colitis, Crohn's disease), intestinal atresia, parasitic diseases (anisakiasis, balantidiasis, blastocystis infections, cryptosporidiosis, dientamoebiasis, amebic dysentery, giardiasis), intestinal fistula (rectal fistula), intestinal neoplasms (cecal neoplasms, colonic neoplasms, duodenal neoplasms, ileal neoplasms, intestinal polyps, jejunal neoplasms, rectal neoplasms), intestinal obstruction (afferent loop syndrome, duodenal obstruction, impacted feces, intestinal pseudo-obstruction [cecal volvulus], intussusception), intestinal perforation, intestinal polyps (colonic polyps, gardner syndrome, peutz-jeghers syndrome), jejunal diseases jejunal neoplasms), malabsorption syndromes (blind loop syndrome, celiac disease, lactose intolerance, short bowl syndrome, tropical sprue, whipple's disease), mesenteric vascular occlusion, pneumatosis cystoides intestinalis, protein-losing enteropathies (intestinal lymphagiectasis), rectal diseases (anus diseases, fecal incontinence, hemorrhoids, proctitis, rectal fistula, rectal prolapse, rectocele), peptic ulcer (duodenal ulcer, peptic esophagitis, hemorrhage, perforation, stomach ulcer, Zollinger-Ellison syndrome), postgastrectomy syndromes (dumping syndrome), stomach diseases (e.g., achlorhydria, duodenogastric reflux (bile reflux), gastric antral vascular ectasia, gastric fistula, gastric outlet obstruction, gastritis (atrophic or hypertrophic), gastroparesis, stomach dilatation, stomach diverticulum, stomach neoplasms (gastric cancer, gastric polyps, gastric adenocarcinoma, hyperplastic gastric polyp), stomach rupture, stomach ulcer, stomach volvulus), tuberculosis, visceroptosis, vomiting (e.g., hematemesis, hyperemesis gravidarum, postoperative nausea and vomiting) and hemorrhagic colitis.

[0776] Further diseases and/or disorders of the gastrointestinal system include biliary tract diseases, such as, gastroschisis, fistula (e.g., biliary fistula, esophageal fistula, gastric fistula, intestinal fistula, pancreatic fistula), neoplasms (e.g., biliary tract neoplasms, esophageal neoplasms, such as adenocarcinoma of the esophagus, esophageal squamous cell carcinoma, gastrointestinal neoplasms, pancreatic neoplasms, such as adenocarcinoma of the pancreas, mucinous cystic neoplasm of the pancreas, pancreatic cystic neoplasms, pancreatoblastoma, and peritoneal neoplasms), esophageal disease (e.g., bullous diseases, candidiasis, glycogenic acanthosis, ulceration, barrett esophagus varices, atresia, cyst, diverticulum (e.g., Zenker's diverticulum), fistula (e.g., tracheoesophageal fistula), motility disorders (e.g., CREST syndrome, deglutition disorders, achalasia, spasm, gastroesophageal reflux), neoplasms, perforation (e.g., Boerhaave syndrome, Mallory-Weiss syndrome), stenosis, esophagitis, diaphragmatic hernia (e.g., hiatal hernia); gastrointestinal diseases, such as, gastroenteritis (e.g., cholera morbus, norwalk virus infection), hemorrhage (e.g., hematemesis, melena, peptic ulcer hemorrhage), stomach neoplasms (gastric cancer, gastric polyps, gastric adenocarcinoma, stomach cancer)), hernia (e.g., congenital diaphragmatic hernia, femoral hernia, inguinal hernia, obturator hernia, umbilical hernia, ventral hernia), and intestinal diseases (e.g., cecal diseases (appendicitis, cecal neoplasms)).

[0777] Developmental and Inherited Disorders

[0778] Polynuceotides or polypeptides, or agonists or antagonists of the present invention may be used to treat, prevent, diagnose, and/or prognose diseases associated with mixed fetal tissues, including, but not limited to, developmental and inherited disorders or defects of the nervous system, musculoskelelal system, execretory system, cardiovascular system, hematopoietic system, gastrointestinal system, reproductive system, and respiratory system. Compositions of the present invention may also be used to treat, prevent, diagnose, and/or prognose developmental and inherited disorders or defects associated with, but not limited to, skin, hair, visual, and auditory tissues, metabolism. Additionally, the compositions of the invention may be useful in the diagnosis, treatment, and/or prevention of disorders or diseases associated with, but not limited to, chromosomal or genetic abnormalities and hyperproliferation or neoplasia.

[0779] Disorders or defects of the nervous system associated with developmental or inherited abnormalities that may be diagnosed, treated, and/or prevented with the compostions of the invention include, but are not limited to, adrenoleukodystrophy, agenesis of corpus callosum, Alexander disease, anencephaly, Angelman syndrome, Arnold-Chiari deformity, Batten disease, Canavan disease, cephalic disorders, Charcot-Marie-Tooth disease, encephalocele, Friedreich's ataxia, Gaucher's disease, Gorlin syndrome, Hallervorden-Spatz disease, hereditary spastic paraplegia, Huntington disease, hydranencephaly, hydrocephalus, Joubert syndrome, Lesch-Nyhan syndrome, leukodystrophy, Menkes disease, microcephaly, Niemann-Pick Type C1, neurofibromatosis, porencephaly, progeria, proteus syndrome, Refsum disease, spina bifida, Sturge-Weber syndrome, Tay-Sachs disease, tuberous sclerosis, and von Hippel-Lindau disease.

[0780] Developmental and inherited disorders resulting in disorders or defects of the musculoskeletal system that may be diagnosed, treated, and/or prevented with the compositions of the invention include, but are not limited to, achondroplasia, atlanto-occipital fusion, arthrogryposis mulitplex congenita, autosomal recessive muscular dystrophy, Becker's muscular dystrophy, cerebral palsy, choanal atresia, cleft lip, cleft palate, clubfoot, congenital amputation, congenital dislocation of the hip, congenital torticollis, congenital scoliosis, dopa-repsonsive dystonia, Duchenne muscular dystrophy, early-onset generalized dystonia, femoral torsion, Gorlin syndrome, hypophosphatasia, Klippel-Feil syndrome, knee dislocation, myoclonic dystonia, myotonic dystrophy, nail-patella syndrome, osteogenesis imperfecta, paroxysmal dystonia, progeria, prune-belly syndrome, rapid-onset dystonia parkinsonism, scolosis, syndactyly, Treacher Collins' syndrome, velocardiofacial syndrome, and X-linked dystonia-parkinsonism.

[0781] Developmental or hereditary disorders or defects of the excretory system that may be diagnosed, treated, and/or prevented with the compositions of the invention include, but are not limited to, Alport's syndrome, Bartter's syndrome, bladder diverticula, bladder exstrophy, cystinuria, epispadias, Fanconi's syndrome, Hartnup disease, horseshoe kidney, hypospadias, kidney agenesis, kidney ectopia, kidney malrotation, Liddle's syndrome, medullary cystic disease, medullary sponge, multicystic kidney, kidney polycystic kidney disease, nail-patella syndrome, Potter's syndrome, urinary tract flow obstruction, vitamin D-resistant rickets, and Wilm's tumor.

[0782] Cardiovascular disorders or defects of developmental or hereditary origin that may be diagnosed, treated, and/or prevented with the compositions of the inventtion include, but are not limited to, aortic valve stenosis, atrial septal defects, artioventricular (A-V) canal defect, bicuspid aortic valve, coarctation or the aorta, dextrocardia, Ebstein's anomaly, Eisenmenger's complex, hypoplastic left heart syndrome, Marfan syndrome, patent ductus arteriosus, progeria, pulmonary atresia, pulmonary valve stenosis, subaortic stenosis, tetralogy of fallot, total anomalous pulmonary venous (P-V) connection, transposition of the great arteries, tricuspid atresia, truncus arteriosus, ventricular septal defects. Developmental or inherited disorders resulting in disorders involving the hematopoietic system that may be diagnosed, treated, and/or prevented with the compositions of the invention include, but not limited to, Bemard-Soulier syndrome, Chédiak-Higashi syndrome, hemophilia, Hermansky-Pudlak syndrome, sickle cell anemia, storage pool disease, thromboxane A2 dysfunction, thrombasthenia, and von Willebrand's disease.

[0783] The compositions of the invention may also be used to diagnose, treat, and/or prevent developmental and inherited disorders resulting in disorders or defects of the gastrointestinal system, including, but not limited to, anal atresia, biliary atresia, esophageal atresia, diaphragmatic hernia, Hirschsprung's disease, Meckel's diverticulum, oligohydramnios, omphalocele, polyhydramnios, porphyria, situs inversus viscera. Developmental or inherited disorders resulting in metabolic disorders that may be diagnosed, treated, and/or prevented with the compositions of the invention include, but are not limited to, alpha-i antitrypsin deficiency, cystic fibrosis, hemochromatosis, lysosomal storage disease, phenylketonuria, Wilson's disease, and Zellweger syndrome.

[0784] Disorders of the reproductive system that are developmentally or hereditary related that may also be diagnosed, treated, and/or prevented with the compositions of the invention include, but are not limited to, androgen insensitivity syndrome, ambiguous genitalia, autosomal sex reversal, congenital adreneal hyperplasia, gonadoblastoma, ovarian germ cell cancer, pseudohermphroditism, true hermaphroditism, undeseended testis, XX male syndrome, and XY female type gonadal dysgenesis. The compositions of the invention may also be used to diagnose, treat, and/or prevent developmental or inherited respiratory defects including, but not limited to, askin tumor, azygos lobe, congenital diaphragmatic hernia, congenital lobar emphysema, cystic adenomatoid malformation, lobar emphysema, hyaline membrane disease, and pectus excavatum.

[0785] Developmental or inherited disorders may also result from chromosomal or genetic aberration that may be diagnosed, treated, and/or prevented with the compositions of the invention including, but not limited to, 4p- syndrome, cri du chat syndrome, Digeorge syndrome, Down's syndrome, Edward's syndrome, fragile X syndrome, Klinefelter's syndrome, Patau's syndrome, Prader-Willi syndrome, progeria, Turner's syndrome, triple X syndrome, and XYY syndrome. Other developmental disorders that can be diagnosed, treated, and/or prevented with the compositions of the invention, include, but are not limited to, fetal alcohol syndrome, and can be caused by environmental factors surrounding the developing fetus.

[0786] The compositions of the invention may further be able to be used to diagnose, treat, and/or prevent errors in development or a genetic disposition that may result in hyperproliferative disorders or neoplasms, including, but not limited to, acute childhood lymphoblastic leukemia, askin tumor, Beckwith-Wiedemann syndrome, childhood acute myeloid leukemia, childhood brain stem glioma, childhood cerebellar astrocytoma, childhood extracranial germ cell tumors childhood (primary), gonadoblastoma, hepatocellular cancer, childhood Hodgkin's disease, childhood Hodgkin's lymphoma, childhood hypothalamic and visual pathway glioma, childhood (primary) liver cancer, childhood lymphoblastic leukemia, childhood medulloblastoma, childhood non-Hodgkin's lymphoma, childhood pineal and supratentorial primitive neuroectodermal tumors, childhood primary liver cancer, childhood rhabdomyosarcoma, childhood soft tissue sarcoma, Gorlin syndrome, familial multiple endrocrine neoplasia type I, neuroblastoma, ovarian germ cell cancer, pheochromocytoma, retinoblastoma, and Wilm's tumor.

[0787] Polypeptides may be administered using any method known in the art, including, but not limited to, direct needle injection at the delivery site, intravenous injection, topical administration, catheter infusion, biolistic injectors, particle accelerators, gelfoam sponge depots, other commercially available depot materials, osmotic pumps, oral or suppositorial solid pharmaceutical formulations, decanting or topical applications during surgery, aerosol delivery. Such methods are known in the art. Polypeptides may be administered as part of a Therapeutic, described in more detail below. Methods of delivering polynucleotides are described in more detail herein.

[0788] Diseases at the Cellular Level

[0789] Diseases associated with increased cell survival or the inhibition of apoptosis that could be treated, prevented, diagnosed and/or prognosed using polynucleotides or polypeptides, as well as antagonists or agonists of the present invention, include cancers (such as follicular lymphomas, carcinomas with p53 mutations, and hormone-dependent tumors, including, but not limited to colon cancer, cardiac tumors, pancreatic cancer, melanoma, retinoblastoma, glioblastoma, lung cancer, intestinal cancer, testicular cancer, stomach cancer, neuroblastoma, myxoma, myoma, lymphoma, endothelioma, osteoblastoma, osteoclastoma, osteosarcoma, chondrosarcoma, adenoma, breast cancer, prostate cancer, Kaposi's sarcoma and ovarian cancer); autoimmune disorders (such as, multiple sclerosis, Sjogren's syndrome, Hashimoto's thyroiditis, biliary cirrhosis, Behcet's disease, Crohn's disease, polymyositis, systemic lupus erythematosus and immune-related glomerulonephritis and rheumatoid arthritis) and viral infections (such as herpes viruses, pox viruses and adenoviruses), inflammation, graft v. host disease, acute graft rejection, and chronic graft rejection.

[0790] In preferred embodiments, polynucleotides, polypeptides, and/or antagonists of the invention are used to inhibit growth, progression, and/or metastasis of cancers, in particular those [listed above] involving reproductive system tissues.

[0791] Additional diseases or conditions associated with increased cell survival that could be treated or detected by polynucleotides or polypeptides, or agonists or antagonists of the present invention include, but are not limited to, progression, and/or metastases of malignancies and related disorders such as leukemia (including acute leukemias (e.g., acute lymphocytic leukemia, acute myelocytic leukemia (including myeloblastic, promyelocytic, myelomonocytic, monocytic, and erythroleukemia)) and chronic leukemias (e.g., chronic myelocytic (granulocytic) leukemia and chronic lymphocytic leukemia)), polycythemia vera, lymphomas (e.g., Hodgkin's disease and non-Hodgkin's disease), multiple myeloma, Waldenstrom's macroglobulinemia, heavy chain disease, and solid tumors including, but not limited to, sarcomas and carcinomas such as fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chordoma, angiosarcoma, endotheliosarcoma, lymphangiosarcoma, lymphangioendotheliosarcoma, synovioma, mesothelioma, Ewing's tumor, leiomyosarcoma, rhabdomyosarcoma, colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, sebaceous gland carcinoma, papillary carcinoma, papillary adenocarcinomas, cystadenocarcinoma, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilm's tumor, cervical cancer, testicular tumor, lung carcinoma, small cell lung carcinoma, bladder carcinoma, epithelial carcinoma, glioma, astrocytoma, medulloblastoma, craniopharyngioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligodendroglioma, menangioma, melanoma, neuroblastoma, and retinoblastoma.

[0792] Diseases associated with increased apoptosis that could be treated, prevented, diagnosted, and/or prognosed using polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, include, but are not limited to, AIDS; neurodegenerative disorders (such as Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Retinitis pigmentosa, Cerebellar degeneration and brain tumor or prior associated disease); autoimmune disorders (such as, multiple sclerosis, Sjogren's syndrome, Hashimoto's thyroiditis, biliary cirrhosis, Behcet's disease, Crohn's disease, polymyositis, systemic lupus erythematosus and immune-related glomerulonephritis and rheumatoid arthritis) myelodysplastic syndromes (such as aplastic anemia), graft v. host disease, ischemic injury (such as that caused by myocardial infarction, stroke and reperfusion injury), liver injury (e.g., hepatitis related liver injury, ischemia/reperfusion injury, cholestosis (bile duct injury) and liver cancer); toxin-induced liver disease (such as that caused by alcohol), septic shock, cachexia and anorexia.

[0793] Wound Healing and Epithelial Cell Proliferation

[0794] In accordance with yet a further aspect of the present invention, there is provided a process for utilizing polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, for therapeutic purposes, for example, to stimulate epithelial cell proliferation and basal keratinocytes for the purpose of wound healing, and to stimulate hair follicle production and healing of dermal wounds. Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, may be clinically useful in stimulating wound healing including surgical wounds, excisional wounds, deep wounds involving damage of the dermis and epidermis, eye tissue wounds, dental tissue wounds, oral cavity wounds, diabetic ulcers, dermal ulcers, cubitus ulcers, arterial ulcers, venous stasis ulcers, burns resulting from heat exposure or chemicals, and other abnormal wound healing conditions such as uremia, malnutrition, vitamin deficiencies and complications associated with systemic treatment with steroids, radiation therapy and antineoplastic drugs and antimetabolites. Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could be used to promote dermal reestablishment subsequent to dermal loss.

[0795] Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could be used to increase the adherence of skin grafts to a wound bed and to stimulate re-epithelialization from the wound bed. The following are types of grafts that polynucleotides or polypeptides, agonists or antagonists of the present invention, could be used to increase adherence to a wound bed: autografts, artificial skin, allografts, autodermic graft, autoepdermic grafts, avacular grafts, Blair-Brown grafts, bone graft, brephoplastic grafts, cutis graft, delayed graft, dermic graft, epidermic graft, fascia graft, full thickness graft, heterologous graft, xenograft, homologous graft, hyperplastic graft, lamellar graft, mesh graft, mucosal graft, Ollier-Thiersch graft, omenpal graft, patch graft, pedicle graft, penetrating graft, split skin graft, thick split graft. Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, can be used to promote skin strength and to improve the appearance of aged skin.

[0796] It is believed that polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, will also produce changes in hepatocyte proliferation, and epithelial cell proliferation in the lung, breast, pancreas, stomach, small intestine, and large intestine. Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could promote proliferation of epithelial cells such as sebocytes, hair follicles, hepatocytes, type II pneumocytes, mucin-producing goblet cells, and other epithelial cells and their progenitors contained within the skin, lung, liver, and gastrointestinal tract. Polynucleotides or polypeptides, agonists or antagonists of the present invention, may promote proliferation of endothelial cells, keratinocytes, and basal keratinocytes.

[0797] Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could also be used to reduce the side effects of gut toxicity that result from radiation, chemotherapy treatments or viral infections. Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, may have a cytoprotective effect on the small intestine mucosa. Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, may also stimulate healing of mucositis (mouth ulcers) that result from chemotherapy and viral infections.

[0798] Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could further be used in full regeneration of skin in full and partial thickness skin defects, including bums, (i.e., repopulation of hair follicles, sweat glands, and sebaceous glands), treatment of other skin defects such as psoriasis. Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could be used to treat epidermolysis bullosa, a defect in adherence of the epidermis to the underlying dermis which results in frequent, open and painful blisters by accelerating reepithelialization of these lesions. Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could also be used to treat gastric and doudenal ulcers and help heal by scar formation of the mucosal lining and regeneration of glandular mucosa and duodenal mucosal lining more rapidly. Inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis, are diseases, which result in destruction of the mucosal surface of the small or large intestine, respectively. Thus, polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could be used to promote the resurfacing of the mucosal surface to aid more rapid healing and to prevent progression of inflammatory bowel disease. Treatment with polynucleotides or polypeptides, agonists or antagonists of the present invention, is expected to have a significant effect on the production of mucus throughout the gastrointestinal tract and could be used to protect the intestinal mucosa from injurious substances that are ingested or following surgery. Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could be used to treat diseases associate with the under expression.

[0799] Moreover, polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could be used to prevent and heal damage to the lungs due to various pathological states. Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could stimulate proliferation and differentiation and promote the repair of alveoli and brochiolar epithelium to prevent or treat acute or chronic lung damage. For example, emphysema, which results in the progressive loss of aveoli, and inhalation injuries, i.e., resulting from smoke inhalation and bums, that cause necrosis of the bronchiolar epithelium and alveoli could be effectively treated using polynucleotides or polypeptides, agonists or antagonists of the present invention. Also, polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could be used to stimulate the proliferation of and differentiation of type II pneumocytes, which may help treat or prevent disease such as hyaline membrane diseases, such as infant respiratory distress syndrome and bronchopulmonary displasia, in premature infants.

[0800] Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could stimulate the proliferation and differentiation of hepatocytes and, thus, could be used to alleviate or treat liver diseases and pathologies such as fulminant liver failure caused by cirrhosis, liver damage caused by viral hepatitis and toxic substances (i.e., acetaminophen, carbon tetraholoride and other hepatotoxins known in the art).

[0801] In addition, polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could be used treat or prevent the onset of diabetes mellitus. In patients with newly diagnosed Types I and II diabetes, where some islet cell function remains, polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could be used to maintain the islet function so as to alleviate, delay or prevent permanent manifestation of the disease. Also, polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, could be used as an auxiliary in islet cell transplantation to improve or promote islet cell function.

[0802] Infectious Diseases

[0803] Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention can be used to treat or detect infectious agents. For example, by increasing the immune response, particularly increasing the proliferation and differentiation of B and/or T cells, infectious diseases may be treated. The immune response may be increased by either enhancing an existing immune response, or by initiating a new immune response. Alternatively, polynucleotides or polypeptides, as well as agonists or antagonists of the present invention may also directly inhibit the infectious agent, without necessarily eliciting an immune response.

[0804] Viruses are one example of an infectious agent that can cause disease or symptoms that can be treated or detected by a polynucleotide or polypeptide and/or agonist or antagonist of the present invention. Examples of viruses, include, but are not limited to Examples of viruses, include, but are not limited to the following DNA and RNA viruses and viral families: Arbovirus, Adenoviridae, Arenaviridae, Arterivirus, Bimaviridae, Bunyaviridae, Caliciviridae, Circoviridae, Coronaviridae, Dengue, EBV, HIV, Flaviviridae, Hepadnaviridae (Hepatitis), Herpesviridae (such as, Cytomegalovirus, Herpes Simplex, Herpes Zoster), Mononegavirus (e.g., Paramyxoviridae, Morbillivirus, Rhabdoviridae), Orthomyxoviridae (e.g., Influenza A, Influenza B, and parainfluenza), Papiloma virus, Papovaviridae, Parvoviridae, Picornaviridae, Poxviridae (such as Smallpox or Vaccinia), Reoviridae (e.g., Rotavirus), Retroviridae (HTLV-I, HTLV-II, Lentivirus), and Togaviridae (e.g., Rubivirus). Viruses falling within these families can cause a variety of diseases or symptoms, including, but not limited to: arthritis, bronchiollitis, respiratory syncytial virus, encephalitis, eye infections (e.g., conjunctivitis, keratitis), chronic fatigue syndrome, hepatitis (A, B, C, E, Chronic Active, Delta), Japanese B encephalitis, Junin, Chikungunya, Rift Valley fever, yellow fever, meningitis, opportunistic infections (e.g., AIDS), pneumonia, Burkitt's Lymphoma, chickenpox, hemorrhagic fever, Measles, Mumps, Parainfluenza, Rabies, the common cold, Polio, leukemia, Rubella, sexually transmitted diseases, skin diseases (e.g., Kaposi's, warts), and viremia. polynucleotides or polypeptides, or agonists or antagonists of the invention, can be used to treat or detect any of these symptoms or diseases. In specific embodiments, polynucleotides, polypeptides, or agonists or antagonists of the invention are used to treat: meningitis, Dengue, EBV, and/or hepatitis (e.g., hepatitis B). In an additional specific embodiment polynucleotides, polypeptides, or agonists or antagonists of the invention are used to treat patients nonresponsive to one or more other commercially available hepatitis vaccines. In a further specific embodiment polynucleotides, polypeptides, or agonists or antagonists of the invention are used to treat AIDS.

[0805] Similarly, bacterial and fungal agents that can cause disease or symptoms and that can be treated or detected by a polynucleotide or polypeptide and/or agonist or antagonist of the present invention include, but not limited to, the following Gram-Negative and Gram-positive bacteria, bacterial families, and fungi: Actinomyces (e.g., Norcardia), Acinetobacter, Cryptococcus neoformans, Aspergillus, Bacillaceae (e.g., Bacillus anthrasis), Bacteroides (e.g., Bacteroides fragilis), Blastomycosis, Bordetella, Borrelia (e.g., Borrelia burgdorferi), Brucella, Candidia, Campylobacter, Chlamydia, Clostridium (e.g., Clostridium botulinum, Clostridium dificile, Clostridium perfringens, Clostridium tetani), Coccidioides, Corynebacterium (e.g., Corynebacterium diptheriae), Cryptococcus, Dermatocycoses, E. coli (e.g., Enterotoxigenic E. coli and Enterohemorrhagic E. coli), Enterobacter (e.g. Enterobacter aerogenes), Enterobacteriaceae (Klebsiella, Salmonella (e.g., Salmonella typhi, Salmonella enteritidis, Salmonella typhi), Serratia, Yersinia, Shigella), Erysipelothrix, Haemophilus (e.g., Haemophilus influenza type B), Helicobacter, Legionella (e.g., Legionella pneumophila), Leptospira, Listeria (e.g., Listeria monocytogenes), Mycoplasma, Mycobacterium (e.g., Mycobacterium leprae and Mycobacterium tuberculosis), Vibrio (e.g., Vibrio cholerae), Neisseriaceae (e.g., Neisseria gonorrhea, Neisseria meningitidis), Pasteurellacea, Proteus, Pseudomonas (e.g., Pseudomonas aeruginosa), Rickettsiaceae, Spirochetes (e.g., Treponema spp., Leptospira spp., Borrelia spp.), Shigella spp., Staphylococcus (e.g., Staphylococcus aureus), Meningiococcus, Pneumococcus and Streptococcus (e.g., Streptococcus pneumoniae and Groups A, B, and C Streptococci), and Ureaplasmas. These bacterial, parasitic, and fungal families can cause diseases or symptoms, including, but not limited to: antibiotic-resistant infections, bacteremia, endocarditis, septicemia, eye infections (e.g., conjunctivitis), uveitis, tuberculosis, gingivitis, bacterial diarrhea, opportunistic infections (e.g., AIDS related infections), paronychia, prosthesis-related infections, dental caries, Reiter's Disease, respiratory tract infections, such as Whooping Cough or Empyema, sepsis, Lyme Disease, Cat-Scratch Disease, dysentery, paratyphoid fever, food poisoning, Legionella disease, chronic and acute inflammation, erythema, yeast infections, typhoid, pneumonia, gonorrhea, meningitis (e.g., mengitis types A and B), chlamydia, syphillis, diphtheria, leprosy, brucellosis, peptic ulcers, anthrax, spontaneous abortions, birth defects, pneumonia, lung infections, ear infections, deafness, blindness, lethargy, malaise, vomiting, chronic diarrhea, Crohn's disease, colitis, vaginosis, sterility, pelvic inflammatory diseases, candidiasis, paratuberculosis, tuberculosis, lupus, botulism, gangrene, tetanus, impetigo, Rheumatic Fever, Scarlet Fever, sexually transmitted diseases, skin diseases (e.g., cellulitis, dermatocycoses), toxemia, urinary tract infections, wound infections, noscomial infections. Polynucleotides or polypeptides, agonists or antagonists of the invention, can be used to treat or detect any of these symptoms or diseases. In specific embodiments, polynucleotides, polypeptides, agonists or antagonists of the invention are used to treat: tetanus, diptheria, botulism, and/or meningitis type B.

[0806] Moreover, parasitic agents causing disease or symptoms that can be treated, prevented, and/or diagnosed by a polynucleotide or polypeptide and/or agonist or antagonist of the present invention include, but not limited to, the following families or class: Amebiasis, Babesiosis, Coccidiosis, Cryptosporidiosis, Dientamoebiasis, Dourine, Ectoparasitic, Giardias, Helminthiasis, Leishmaniasis, Schistisoma, Theileriasis, Toxoplasmosis, Trypanosomiasis, and Trichomonas and Sporozoans (e.g., Plasmodium virax, Plasmodium falciparium, Plasmodium malariae and Plasmodium ovale). These parasites can cause a variety of diseases or symptoms, including, but not limited to: Scabies, Trombiculiasis, eye infections, intestinal disease (e.g., dysentery, giardiasis), liver disease, lung disease, opportunistic infections (e.g., AIDS related), malaria, pregnancy complications, and toxoplasmosis. polynucleotides or polypeptides, or agonists or antagonists of the invention, can be used to treat, prevent, and/or diagnose any of these symptoms or diseases. In specific embodiments, polynucleotides, polypeptides, or agonists or antagonists of the invention are used to treat, prevent, and/or diagnose malaria.

[0807] Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention of the present invention could either be by administering an effective amount of a polypeptide to the patient, or by removing cells from the patient, supplying the cells with a polynucleotide of the present invention, and returning the engineered cells to the patient (ex vivo therapy). Moreover, the polypeptide or polynucleotide of the present invention can be used as an antigen in a vaccine to raise an immune response against infectious disease.

[0808] Regeneration

[0809] Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention can be used to differentiate, proliferate, and attract cells, leading to the regeneration of tissues. (See, Science 276:59-87 (1997).) The regeneration of tissues could be used to repair, replace, or protect tissue damaged by congenital defects, trauma (wounds, burns, incisions, or ulcers), age, disease (e.g. osteoporosis, osteocarthritis, periodontal disease, liver failure), surgery, including cosmetic plastic surgery, fibrosis, reperfusion injury, or systemic cytokine damage.

[0810] Tissues that could be regenerated using the present invention include organs (e.g., pancreas, liver, intestine, kidney, skin, endothelium), muscle (smooth, skeletal or cardiac), vasculature (including vascular and lymphatics), nervous, hematopoietic, and skeletal (bone, cartilage, tendon, and ligament) tissue. Preferably, regeneration occurs without or decreased scarring. Regeneration also may include angiogenesis.

[0811] Moreover, polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, may increase regeneration of tissues difficult to heal. For example, increased tendon/ligament regeneration would quicken recovery time after damage. Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention could also be used prophylactically in an effort to avoid damage. Specific diseases that could be treated include of tendinitis, carpal tunnel syndrome, and other tendon or ligament defects. A further example of tissue regeneration of non-healing wounds includes pressure ulcers, ulcers associated with vascular insufficiency, surgical, and traumatic wounds.

[0812] Similarly, nerve and brain tissue could also be regenerated by using polynucleotides or polypeptides, as well as agonists or antagonists of the present invention, to proliferate and differentiate nerve cells. Diseases that could be treated using this method include central and peripheral nervous system diseases, neuropathies, or mechanical and traumatic disorders (e.g., spinal cord disorders, head trauma, cerebrovascular disease, and stoke). Specifically, diseases associated with peripheral nerve injuries, peripheral neuropathy (e.g., resulting from chemotherapy or other medical therapies), localized neuropathies, and central nervous system diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Shy-Drager syndrome), could all be treated using the polynucleotides or polypeptides, as well as agonists or antagonists of the present invention.

[0813] Chemotaxis

[0814] Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention may have chemotaxis activity. A chemotaxic molecule attracts or mobilizes cells (e.g., monocytes, fibroblasts, neutrophils, T-cells, mast cells, eosinophils, epithelial and/or endothelial cells) to a particular site in the body, such as inflammation, infection, or site of hyperproliferation. The mobilized cells can then fight off and/or heal the particular trauma or abnormality.

[0815] Polynucleotides or polypeptides, as well as agonists or antagonists of the present invention may increase chemotaxic activity of particular cells. These chemotactic molecules can then be used to treat inflammation, infection, hyperproliferative disorders, or any immune system disorder by increasing the number of cells targeted to a particular location in the body. For example, chemotaxic molecules can be used to treat wounds and other trauma to tissues by attracting immune cells to the injured location. Chemotactic molecules of the present invention can also attract fibroblasts, which can be used to treat wounds.

[0816] It is also contemplated that polynucleotides or polypeptides, as well as agonists or antagonists of the present invention may inhibit chemotactic activity. These molecules could also be used to treat disorders. Thus, polynucleotides or polypeptides, as well as agonists or antagonists of the present invention could be used as an inhibitor of chemotaxis.

[0817] Binding Activity

[0818] A polypeptide of the present invention may be used to screen for molecules that bind to the polypeptide or for molecules to which the polypeptide binds. The binding of the polypeptide and the molecule may activate (agonist), increase, inhibit (antagonist), or decrease activity of the polypeptide or the molecule bound. Examples of such molecules include antibodies, oligonucleotides, proteins (e.g., receptors),or small molecules.

[0819] Preferably, the molecule is closely related to the natural ligand of the polypeptide, e.g., a fragment of the ligand, or a natural substrate, a ligand, a structural or functional mimetic. (See, Coligan et al., Current Protocols in Immunology 1(2):Chapter 5 (1991).) Similarly, the molecule can be closely related to the natural receptor to which the polypeptide binds, or at least, a fragment of the receptor capable of being bound by the polypeptide (e.g., active site). In either case, the molecule can be rationally designed using known techniques.

[0820] Preferably, the screening for these molecules involves producing appropriate cells which express the polypeptide. Preferred cells include cells from mammals, yeast, Drosophila, or E. coli. Cells expressing the polypeptide (or cell membrane containing the expressed polypeptide) are then preferably contacted with a test compound potentially containing the molecule to observe binding, stimulation, or inhibition of activity of either the polypeptide or the molecule.

[0821] The assay may simply test binding of a candidate compound to the polypeptide, wherein binding is detected by a label, or in an assay involving competition with a labeled competitor. Further, the assay may test whether the candidate compound results in a signal generated by binding to the polypeptide.

[0822] Alternatively, the assay can be carried out using cell-free preparations, polypeptide/molecule affixed to a solid support, chemical libraries, or natural product mixtures. The assay may also simply comprise the steps of mixing a candidate compound with a solution containing a polypeptide, measuring polypeptide/molecule activity or binding, and comparing the polypeptide/molecule activity or binding to a standard.

[0823] Preferably, an ELISA assay can measure polypeptide level or activity in a sample (e.g., biological sample) using a monoclonal or polyclonal antibody. The antibody can measure polypeptide level or activity by either binding, directly or indirectly, to the polypeptide or by competing with the polypeptide for a substrate.

[0824] Additionally, the receptor to which the polypeptide of the present invention binds can be identified by numerous methods known to those of skill in the art, for example, ligand panning and FACS sorting (Coligan, et al., Current Protocols in Immun., 1(2), Chapter 5, (1991)). For example, expression cloning is employed wherein polyadenylated RNA is prepared from a cell responsive to the polypeptides, for example, NIH3T3 cells which are known to contain multiple receptors for the FGF family proteins, and SC-3 cells, and a cDNA library created from this RNA is divided into pools and used to transfect COS cells or other cells that are not responsive to the polypeptides. Transfected cells which are grown on glass slides are exposed to the polypeptide of the present invention, after they have been labeled. The polypeptides can be labeled by a variety of means including iodination or inclusion of a recognition site for a site-specific protein kinase.

[0825] Following fixation and incubation, the slides are subjected to auto-radiographic analysis. Positive pools are identified and sub-pools are prepared and re-transfected using an iterative sub-pooling and re-screening process, eventually yielding a single clones that encodes the putative receptor.

[0826] As an alternative approach for receptor identification, the labeled polypeptides can be photoaffinity linked with cell membrane or extract preparations that express the receptor molecule. Cross-linked material is resolved by PAGE analysis and exposed to X-ray film. The labeled complex containing the receptors of the polypeptides can be excised, resolved into peptide fragments, and subjected to protein microsequencing. The amino acid sequence obtained from microsequencing would be used to design a set of degenerate oligonucleotide probes to screen a cDNA library to identify the genes encoding the putative receptors.

[0827] Moreover, the techniques of gene-shuffling, motif-shuffling, exon-shuffling, and/or codon-shuffling (collectively referred to as “DNA shuffling”) may be employed to modulate the activities of the polypeptide of the present invention thereby effectively generating agonists and antagonists of the polypeptide of the present invention. See generally, U.S. Pat. Nos. 5,605,793, 5,811,238, 5,830,721, 5,834,252, and 5,837,458, and Patten, P. A., et al., Curr. Opinion Biotechnol. 8:724-33 (1997); Harayama, S. Trends Biotechnol. 16(2):76-82 (1998); Hansson L. O., et al., J. Mol. Biol. 287:265-76 (1999); and Lorenzo, M. M. and Blasco, R. Biotechniques 24(2):308-13 (1998); each of these patents and publications are hereby incorporated by reference). In one embodiment, alteration of polynucleotides and corresponding polypeptides may be achieved by DNA shuffling. DNA shuffling involves the assembly of two or more DNA segments into a desired molecule by homologous, or site-specific, recombination. In another embodiment, polynucleotides and corresponding polypeptides may be altered by being subjected to random mutagenesis by error-prone PCR, random nucleotide insertion or other methods prior to recombination. In another embodiment, one or more components, motifs, sections, parts, domains, fragments, etc., of the polypeptide of the present invention may be recombined with one or more components, motifs, sections, parts, domains, fragments, etc. of one or more heterologous molecules. In preferred embodiments, the heterologous molecules are family members. In further preferred embodiments, the heterologous molecule is a growth factor such as, for example, platelet-derived growth factor (PDGF), insulin-like growth factor (IGF-I), transforming growth factor (TGF)-alpha, epidermal growth factor (EGF), fibroblast growth factor (FGF), TGF-beta, bone morphogenetic protein (BMP)-2, BMP-4, BMP-5, BMP-6, BMP-7, activins A and B, decapentaplegic(dpp), 60A, OP-2, dorsalin, growth differentiation factors (GDFs), nodal, MIS, inhibin-alpha, TGF-betal, TGF-beta2, TGF-beta3, TGF-beta5, and glial-derived neurotrophic factor (GDNF).

[0828] Other preferred fragments are biologically active fragments of the polypeptide of the present invention. Biologically active fragments are those exhibiting activity similar, but not necessarily identical, to an activity of the polypeptide of the present invention. The biological activity of the fragments may include an improved desired activity, or a decreased undesirable activity.

[0829] Additionally, this invention provides a method of screening compounds to identify those which modulate the action of the polypeptide of the present invention. An example of such an assay comprises combining a mammalian fibroblast cell, the polypeptide of the present invention, the compound to be screened and ³[H] thymidine under cell culture conditions where the fibroblast cell would normally proliferate. A control assay may be performed in the absence of the compound to be screened and compared to the amount of fibroblast proliferation in the presence of the compound to determine if the compound stimulates proliferation by determining the uptake of 3[H] thymidine in each case. The amount of fibroblast cell proliferation is measured by liquid scintillation chromatography which measures the incorporation of ³[H] thymidine. Both agonist and antagonist compounds may be identified by this procedure.

[0830] In another method, a mammalian cell or membrane preparation expressing a receptor for a polypeptide of the present invention is incubated with a labeled polypeptide of the present invention in the presence of the compound. The ability of the compound to enhance or block this interaction could then be measured. Alternatively, the response of a known second messenger system following interaction of a compound to be screened and the receptor is measured and the ability of the compound to bind to the receptor and elicit a second messenger response is measured to determine if the compound is a potential agonist or antagonist. Such second messenger systems include but are not limited to, cAMP guanylate cyclase, ion channels or phosphoinositide hydrolysis.

[0831] All of these above assays can be used as diagnostic or prognostic markers. The molecules discovered using these assays can be used to treat disease or to bring about a particular result in a patient (e.g., blood vessel growth) by activating or inhibiting the polypeptide/molecule. Moreover, the assays can discover agents which may inhibit or enhance the production of the polypeptides of the invention from suitably manipulated cells or tissues.

[0832] Therefore, the invention includes a method of identifying compounds which bind to a polypeptide of the invention comprising the steps of: (a) incubating a candidate binding compound with a polypeptide of the present invention; and (b) determining if binding has occurred. Moreover, the invention includes a method of identifying agonists/antagonists comprising the steps of: (a) incubating a candidate compound with a polypeptide of the present invention, (b) assaying a biological activity, and (b) determining if a biological activity of the polypeptide has been altered.

[0833] Targeted Delivery

[0834] In another embodiment, the invention provides a method of delivering compositions to targeted cells expressing a receptor for a polypeptide of the invention, or cells expressing a cell bound form of a polypeptide of the invention.

[0835] As discussed herein, polypeptides or antibodies of the invention may be associated with heterologous polypeptides, heterologous nucleic acids, toxins, or prodrugs via hydrophobic, hydrophilic, ionic and/or covalent interactions. In one embodiment, the invention provides a method for the specific delivery of compositions of the invention to cells by administering polypeptides of the invention (including antibodies) that are associated with heterologous polypeptides or nucleic acids. In one example, the invention provides a method for delivering a therapeutic protein into the targeted cell. In another example, the invention provides a method for delivering a single stranded nucleic acid (e.g., antisense or ribozymes) or double stranded nucleic acid (e.g., DNA that can integrate into the cell's genome or replicate episomally and that can be transcribed) into the targeted cell.

[0836] In another embodiment, the invention provides a method for the specific destruction of cells (e.g., the destruction of tumor cells) by administering polypeptides of the invention (e.g., polypeptides of the invention or antibodies of the invention) in association with toxins or cytotoxic prodrugs.

[0837] By “toxin” is meant compounds that bind and activate endogenous cytotoxic effector systems, radioisotopes, holotoxins, modified toxins, catalytic subunits of toxins, or any molecules or enzymes not normally present in or on the surface of a cell that under defined conditions cause the cell's death. Toxins that may be used according to the methods of the invention include, but are not limited to, radioisotopes known in the art, compounds such as, for example, antibodies (or complement fixing containing portions thereof) that bind an inherent or induced endogenous cytotoxic effector system, thymidine kinase, endonuclease, RNAse, alpha toxin, ricin, abrin, Pseudomonas exotoxin A, diphtheria toxin, saporin, momordin, gelonin, pokeweed antiviral protein, alpha-sarcin and cholera toxin. By “cytotoxic prodrug” is meant a non-toxic compound that is converted by an enzyme, normally present in the cell, into a cytotoxic compound. Cytotoxic prodrugs that may be used according to the methods of the invention include, but are not limited to, glutamyl derivatives of benzoic acid mustard alkylating agent, phosphate derivatives of etoposide or mitomycin C, cytosine arabinoside, daunorubisin, and phenoxyacetamide derivatives of doxorubicin.

[0838] Drug Screening

[0839] Further contemplated is the use of the polypeptides of the present invention, or the polynucleotides encoding these polypeptides, to screen for molecules which modify the activities of the polypeptides of the present invention. Such a method would include contacting the polypeptide of the present invention with a selected compound(s) suspected of having antagonist or agonist activity, and assaying the activity of these polypeptides following binding.

[0840] This invention is particularly useful for screening therapeutic compounds by using the polypeptides of the present invention, or binding fragments thereof, in any of a variety of drug screening techniques. The polypeptide or fragment employed in such a test may be affixed to a solid support, expressed on a cell surface, free in solution, or located intracellularly. One method of drug screening utilizes eukaryotic or prokaryotic host cells which are stably transformed with recombinant nucleic acids expressing the polypeptide or fragment. Drugs are screened against such transformed cells in competitive binding assays. One may measure, for example, the formulation of complexes between the agent being tested and a polypeptide of the present invention.

[0841] Thus, the present invention provides methods of screening for drugs or any other agents which affect activities mediated by the polypeptides of the present invention. These methods comprise contacting such an agent with a polypeptide of the present invention or a fragment thereof and assaying for the presence of a complex between the agent and the polypeptide or a fragment thereof, by methods well known in the art. In such a competitive binding assay, the agents to screen are typically labeled. Following incubation, free agent is separated from that present in bound form, and the amount of free or uncomplexed label is a measure of the ability of a particular agent to bind to the polypeptides of the present invention.

[0842] Another technique for drug screening provides high throughput screening for compounds having suitable binding affinity to the polypeptides of the present invention, and is described in great detail in European Patent Application 84/03564, published on Sep. 13, 1984, which is incorporated herein by reference herein. Briefly stated, large numbers of different small peptide test compounds are synthesized on a solid substrate, such as plastic pins or some other surface. The peptide test compounds are reacted with polypeptides of the present invention and washed. Bound polypeptides are then detected by methods well known in the art. Purified polypeptides are coated directly onto plates for use in the aforementioned drug screening techniques. In addition, non-neutralizing antibodies may be used to capture the peptide and immobilize it on the solid support.

[0843] This invention also contemplates the use of competitive drug screening assays in which neutralizing antibodies capable of binding polypeptides of the present invention specifically compete with a test compound for binding to the polypeptides or fragments thereof. In this manner, the antibodies are used to detect the presence of any peptide which shares one or more antigenic epitopes with a polypeptide of the invention.

[0844] Antisense And Ribozyme (Antagonists)

[0845] In specific embodiments, antagonists according to the present invention are nucleic acids corresponding to the sequences contained in SEQ ID NO: X, or the complementary strand thereof, and/or to cDNA sequences contained in cDNA Clone ID NO: Z identified for example, in Table 1A. In one embodiment, antisense sequence is generated internally, by the organism, in another embodiment, the antisense sequence is separately administered (see, for example, O'Connor, J., Neurochem. 56:560 (1991). Oligodeoxynucleotides as Antisense Inhibitors of Gene Expression, CRC Press, Boca Raton, Fla. (1988). Antisense technology can be used to control gene expression through antisense DNA or RNA, or through triple-helix formation. Antisense techniques are discussed for example, in Okano, J., Neurochem. 56:560 (1991); Oligodeoxynucleotides as Antisense Inhibitors of Gene Expression, CRC Press, Boca Raton, Fla. (1988). Triple helix formation is discussed in, for instance, Lee et al., Nucleic Acids Research 6:3073 (1979); Cooney et al., Science 241:456 (1988); and Dervan et al., Science 251:1300 (1991). The methods are based on binding of a polynucleotide to a complementary DNA or RNA.

[0846] For example, the use of c-myc and c-myb antisense RNA constructs to inhibit the growth of the non-lymphocytic leukemia cell line HL-60 and other cell lines was previously described. (Wickstrom et al. (1988); Anfossi et al. (1989)). These experiments were performed in vitro by incubating cells with the oligoribonucleotide. A similar procedure for in vivo use is described in WO 91/15580. Briefly, a pair of oligonucleotides for a given antisense RNA is produced as follows: A sequence complimentary to the first 15 bases of the open reading frame is flanked by an EcoR1 site on the 5′ end and a HindIII site on the 3′ end. Next, the pair of oligonucleotides is heated at 90° C. for one minute and then annealed in 2× ligation buffer (20mM TRIS HCl pH 7.5, 10 mM MgCl2, 10 MM dithiothreitol (DTT) and 0.2 mM ATP) and then ligated to the EcoR1/Hind III site of the retroviral vector PMV7 (WO 91/15580).

[0847] For example, the 5′ coding portion of a polynucleotide that encodes the polypeptide of the present invention may be used to design an antisense RNA oligonucleotide of from about 10 to 40 base pairs in length. A DNA oligonucleotide is designed to be complementary to a region of the gene involved in transcription thereby preventing transcription and the production of the receptor. The antisense RNA oligonucleotide hybridizes to the mRNA in vivo and blocks translation of the MRNA molecule into receptor polypeptide.

[0848] In one embodiment, the antisense nucleic acid of the invention is produced intracellularly by transcription from an exogenous sequence. For example, a vector or a portion thereof, is transcribed, producing an antisense nucleic acid (RNA) of the invention. Such a vector would contain a sequence encoding the antisense nucleic acid. Such a vector can remain episomal or become chromosomally integrated, as long as it can be transcribed to produce the desired antisense RNA. Such vectors can be constructed by recombinant DNA technology methods standard in the art. Vectors can be plasmid, viral, or others known in the art, used for replication and expression in vertebrate cells. Expression of the sequence encoding the polypeptide of the present invention or fragments thereof, can be by any promoter known in the art to act in vertebrate, preferably human cells. Such promoters can be inducible or constitutive. Such promoters include, but are not limited to, the SV40 early promoter region (Bernoist and Chambon, Nature 29:304-310 (1981), the promoter contained in the 3′ long terminal repeat of Rous sarcoma virus (Yamamoto et al., Cell 22:787-797 (1980), the herpes thymidine promoter (Wagner et al., Proc. Natl. Acad. Sci. U.S.A. 78:1441-1445 (1981), the regulatory sequences of the metallothionein gene (Brinster, et al., Nature 296:39-42 (1982)), etc.

[0849] The antisense nucleic acids of the invention comprise a sequence complementary to at least a portion of an RNA transcript of a gene of the present invention. However, absolute complementarity, although preferred, is not required. A sequence “complementary to at least a portion of an RNA,” referred to herein, means a sequence having sufficient complementarity to be able to hybridize with the RNA, forming a stable duplex; in the case of double stranded antisense nucleic acids, a single strand of the duplex DNA may thus be tested, or triplex formation may be assayed. The ability to hybridize will depend on both the degree of complementarity and the length of the antisense nucleic acid. Generally, the larger the hybridizing nucleic acid, the more base mismatches with a RNA it may contain and still form a stable duplex (or triplex as the case may be). One skilled in the art can ascertain a tolerable degree of mismatch by use of standard procedures to determine the melting point of the hybridized complex.

[0850] Oligonucleotides that are complementary to the 5′ end of the message, e.g., the 5′ untranslated sequence up to and including the AUG initiation codon, should work most efficiently at inhibiting translation. However, sequences complementary to the 3′ untranslated sequences of mRNAs have been shown to be effective at inhibiting translation of mRNAs as well. See generally, Wagner, R., 1994, Nature 372:333-335. Thus, oligonucleotides complementary to either the 5′- or 3′-non-translated, non-coding regions of polynucleotide sequences described herein could be used in an antisense approach to inhibit translation of endogenous mRNA. Oligonucleotides complementary to the 5′ untranslated region of the mRNA should include the complement of the AUG start codon. Antisense oligonucleotides complementary to mRNA coding regions are less efficient inhibitors of translation but could be used in accordance with the invention. Whether designed to hybridize to the 5′-, 3′- or coding region of MRNA of the present invention, antisense nucleic acids should be at least six nucleotides in length, and are preferably oligonucleotides ranging from 6 to about 50 nucleotides in length. In specific aspects the oligonucleotide is at least 10 nucleotides, at least 17 nucleotides, at least 25 nucleotides or at least 50 nucleotides.

[0851] The polynucleotides of the invention can be DNA or RNA or chimeric mixtures or derivatives or modified versions thereof, single-stranded or double-stranded. The oligonucleotide can be modified at the base moiety, sugar moiety, or phosphate backbone, for example, to improve stability of the molecule, hybridization, etc. The oligonucleotide may include other appended groups such as peptides (e.g., for targeting host cell receptors in vivo), or agents facilitating transport across the cell membrane (see, e.g., Letsinger et al., 1989, Proc. Natl. Acad. Sci. U.S.A. 86:6553-6556; Lemaitre et al., 1987, Proc. Natl. Acad. Sci. 84:648-652; PCT Publication No. WO88/09810, published Dec. 15, 1988) or the blood-brain barrier (see, e.g., PCT Publication No. WO89/10134, published Apr. 25, 1988), hybridization-triggered cleavage agents. (See, e.g., Krol et al., 1988, BioTechniques 6:958-976) or intercalating agents. (See, e.g., Zon, 1988, Pharm. Res. 5:539-549). To this end, the oligonucleotide may be conjugated to another molecule, e.g., a peptide, hybridization triggered cross-linking agent, transport agent, hybridization-triggered cleavage agent, etc.

[0852] The antisense oligonucleotide may comprise at least one modified base moiety which is selected from the group including, but not limited to, 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xantine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine.

[0853] The antisense oligonucleotide may also comprise at least one modified sugar moiety selected from the group including, but not limited to, arabinose, 2-fluoroarabinose, xylulose, and hexose.

[0854] In yet another embodiment, the antisense oligonucleotide comprises at least one modified phosphate backbone selected from the group including, but not limited to, a phosphorothioate, a phosphorodithioate, a phosphoramidothioate, a phosphoramidate, a phosphordiamidate, a methylphosphonate, an alkyl phosphotriester, and a formacetal or analog thereof.

[0855] In yet another embodiment, the antisense oligonucleotide is an a-anomeric oligonucleotide. An a-anomeric oligonucleotide forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual b-units, the strands run parallel to each other (Gautier et al., 1987, Nucl. Acids Res. 15:6625-6641). The oligonucleotide is a 2′-0-methylribonucleotide (Inoue et al., 1987, Nucl. Acids Res. 15:6131-6148), or a chimeric RNA-DNA analogue (Inoue et al., 1987, FEBS Lett. 215:327-330).

[0856] Polynucleotides of the invention may be synthesized by standard methods known in the art, e.g. by use of an automated DNA synthesizer (such as are commercially available from Biosearch, Applied Biosystems, etc.). As examples, phosphorothioate oligonucleotides may be synthesized by the method of Stein et al. (1988, Nucl. Acids Res. 16:3209), methylphosphonate oligonucleotides can be prepared by use of controlled pore glass polymer supports (Sarin et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85:7448-7451), etc.

[0857] While antisense nucleotides complementary to the coding region sequence could be used, those complementary to the transcribed untranslated region are most preferred.

[0858] Potential antagonists according to the invention also include catalytic RNA, or a ribozyme (See, e.g., PCT International Publication WO 90/11364, published Oct. 4, 1990; Sarver et al, Science 247:1222-1225 (1990). While ribozymes that cleave mRNA at site specific recognition sequences can be used to destroy mRNAs, the use of hammerhead ribozymes is preferred. Hammerhead ribozymes cleave mRNAs at locations dictated by flanking regions that form complementary base pairs with the target MRNA. The sole requirement is that the target mRNA have the following sequence of two bases: 5′-UG-3′. The construction and production of hammerhead ribozymes is well known in the art and is described more fully in Haseloff and Gerlach, Nature 334:585-591 (1988). There are numerous potential hammerhead ribozyme cleavage sites within the nucleotide sequence of SEQ ID NO: X. Preferably, the ribozyme is engineered so that the cleavage recognition site is located near the 5′ end of the mRNA; i.e., to increase efficiency and minimize the intracellular accumulation of non-functional mRNA transcripts.

[0859] As in the antisense approach, the ribozymes of the invention can be composed of modified oligonucleotides (e.g. for improved stability, targeting, etc.) and should be delivered to cells which express in vivo. DNA constructs encoding the ribozyme may be introduced into the cell in the same manner as described above for the introduction of antisense encoding DNA. A preferred method of delivery involves using a DNA construct “encoding” the ribozyme under the control of a strong constitutive promoter, such as, for example, pol III or pol II promoter, so that transfected cells will produce sufficient quantities of the ribozyme to destroy endogenous messages and inhibit translation. Since ribozymes unlike antisense molecules, are catalytic, a lower intracellular concentration is required for efficiency.

[0860] Antagonist/agonist compounds may be employed to inhibit the cell growth and proliferation effects of the polypeptides of the present invention on neoplastic cells and tissues, i.e. stimulation of angiogenesis of tumors, and, therefore, retard or prevent abnormal cellular growth and proliferation, for example, in tumor formation or growth.

[0861] The antagonist/agonist may also be employed to prevent hyper-vascular diseases, and prevent the proliferation of epithelial lens cells after extracapsular cataract surgery. Prevention of the mitogenic activity of the polypeptides of the present invention may also be desirous in cases such as restenosis after balloon angioplasty.

[0862] The antagonist/agonist may also be employed to prevent the growth of scar tissue during wound healing.

[0863] The antagonist/agonist may also be employed to treat the diseases described herein.

[0864] Thus, the invention provides a method of treating disorders or diseases, including but not limited to the disorders or diseases listed throughout this application, associated with overexpression of a polynucleotide of the present invention by administering to a patient (a) an antisense molecule directed to the polynucleotide of the present invention, and/or (b) a ribozyme directed to the polynucleotide of the present invention.

[0865] Binding, Peptides and Other Molecules

[0866] The invention also encompasses screening methods for identifying polypeptides and nonpolypeptides that bind reproductive system related antigen polypeptides, and the reproductive system related antigen binding molecules identified thereby. These binding molecules are useful, for example, as agonists and antagonists of the reproductive system related antigen polypeptides. Such agonists and antagonists can be used, in accordance with the invention, in the therapeutic embodiments described in detail, below.

[0867] This method comprises the steps of: contacting reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides with a plurality of molecules; and identifying a molecule that binds the reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides.

[0868] The step of contacting the reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides with the plurality of molecules may be effected in a number of ways. For example, one may contemplate immobilizing the reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides on a solid support and bringing a solution of the plurality of molecules in contact with the immobilized reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides. Such a procedure would be akin to an affinity chromatographic process, with the affinity matrix being comprised of the immobilized reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides. The molecules having a selective affinity for the reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides can then be purified by affinity selection. The nature of the solid support, process for attachment of the reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides to the solid support, solvent, and conditions of the affinity isolation or selection are largely conventional and well known to those of ordinary skill in the art.

[0869] Alternatively, one may also separate a plurality of polypeptides into substantially separate fractions comprising a subset of or individual polypeptides. For instance, one can separate the plurality of polypeptides by gel electrophoresis, column chromatography, or like method known to those of ordinary skill for the separation of polypeptides. The individual polypeptides can also be produced by a transformed host cell in such a way as to be expressed on or about its outer surface (e.g., a recombinant phage). Individual isolates can then be “probed” by the reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides, optionally in the presence of an inducer should one be required for expression, to determine if any selective affinity interaction takes place between the reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides and the individual clone. Prior to contacting the reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides with each fraction comprising individual polypeptides, the polypeptides could first be transferred to a solid support for additional convenience. Such a solid support may simply be a piece of filter membrane, such as one made of nitrocellulose or nylon. In this manner, positive clones could be identified from a collection of transformed host cells of an expression library, which harbor a DNA construct encoding a polypeptide having a selective affinity for reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides. Furthermore, the amino acid sequence of the polypeptide having a selective affinity for the reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides can be determined directly by conventional means or the coding sequence of the DNA encoding the polypeptide can frequently be determined more conveniently. The primary sequence can then be deduced from the corresponding DNA sequence. If the amino acid sequence is to be determined from the polypeptide itself, one may use microsequencing techniques. The sequencing technique may include mass spectroscopy.

[0870] In certain situations, it may be desirable to wash away any unbound reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides, or alternatively, unbound polypeptides, from a mixture of the reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides and the plurality of polypeptides prior to attempting to determine or to detect the presence of a selective affinity interaction. Such a wash step may be particularly desirable when the reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides or the plurality of polypeptides is bound to a solid support.

[0871] The plurality of molecules provided according to this method may be provided by way of diversity libraries, such as random or combinatorial peptide or nonpeptide libraries which can be screened for molecules that specifically bind reproductive system related antigen polypeptides. Many libraries are known in the art that can be used, e.g., chemically synthesized libraries, recombinant (e.g., phage display libraries), and in vitro translation-based libraries. Examples of chemically synthesized libraries are described in Fodor et al., 1991, Science 251:767-773; Houghten et al., 1991, Nature 354:84-86; Lam et al., 1991, Nature 354:82-84; Medynski, 1994, Bio/Technology 12:709-710;Gallop et al., 1994, J. Medicinal Chemistry 37(9):1233-1251; Ohlmeyer et al., 1993, Proc. Natl. Acad. Sci. USA 90:10922-10926; Erb et al., 1994, Proc. Natl. Acad. Sci. USA 91:11422-11426; Houghten et al., 1992, Biotechniques 13:412; Jayawickreme et al., 1994, Proc. Natl. Acad. Sci. USA 91:1614-1618; Salmon et al., 1993, Proc. Natl. Acad. Sci. USA 90:11708-11712; PCT Publication No. WO 93/20242; and Brenner and Lemer, 1992, Proc. Natl. Acad. Sci. USA 89:5381-5383.

[0872] Examples of phage display libraries are described in Scott and Smith, 1990, Science 249:386-390; Devlin et al., 1990, Science, 249:404-406; Christian, R. B., et al., 1992, J. Mol. Biol. 227:711-718); Lenstra, 1992, J. Immunol. Meth. 152:149-157; Kay et al., 1993, Gene 128:59-65; and PCT Publication No. WO 94/18318 dated Aug. 18, 1994.

[0873] In vitro translation-based libraries include but are not limited to those described in PCT Publication No. WO 91/05058 dated Apr. 18, 1991; and Mattheakis et al., 1994, Proc. Natl. Acad. Sci. USA 91:9022-9026.

[0874] By way of examples of nonpeptide libraries, a benzodiazepine library (see e.g., Bunin et al., 1994, Proc. Natl. Acad. Sci. USA 91:4708-4712) can be adapted for use. Peptoid libraries (Simon et al., 1992, Proc. Natl. Acad. Sci. USA 89:9367-9371) can also be used. Another example of a library that can be used, in which the amide functionalities in peptides have been permethylated to generate a chemically transformed combinatorial library, is described by Ostresh et al. (1994, Proc. Natl. Acad. Sci. USA 91:11138-11142).

[0875] The variety of non-peptide libraries that are useful in the present invention is great. For example, Ecker and Crooke, 1995, Bio/Technology 13:351-360 list benzodiazepines, hydantoins, piperazinediones, biphenyls, sugar analogs, beta-mercaptoketones, arylacetic acids, acylpiperidines, benzopyrans, cubanes, xanthines, aminimides, and oxazolones as among the chemical species that form the basis of various libraries.

[0876] Non-peptide libraries can be classified broadly into two types: decorated monomers and oligomers. Decorated monomer libraries employ a relatively simple scaffold structure upon which a variety functional groups is added. Often the scaffold will be a molecule with a known useful pharmacological activity. For example, the scaffold might be the benzodiazepine structure.

[0877] Non-peptide oligomer libraries utilize a large number of monomers that are assembled together in ways that create new shapes that depend on the order of the monomers. Among the monomer units that have been used are carbamates, pyrrolinones, and morpholinos. Peptoids, peptide-like oligomers in which the side chain is attached to the alpha amino group rather than the alpha carbon, form the basis of another version of non-peptide oligomer libraries. The first non-peptide oligomer libraries utilized a single type of monomer and thus contained a repeating backbone. Recent libraries have utilized more than one monomer, giving the libraries added flexibility.

[0878] Screening the libraries can be accomplished by any of a variety of commonly known methods. See, e.g., the following references, which disclose screening of peptide libraries: Parmley and Smith, 1989, Adv. Exp. Med. Biol. 251:215-218; Scott and Smith, 1990, Science 249:386-390; Fowlkes et al., 1992; BioTechniques 13:422-427; Oldenburg et al., 1992, Proc. Natl. Acad. Sci. USA 89:5393-5397; Yu et al., 1994, Cell 76:933-945; Staudt et al., 1988, Science 241:577-580; Bock et al., 1992, Nature 355:564-566; Tuerk et al., 1992, Proc. Natl. Acad. Sci. USA 89:6988-6992; Ellington et al., 1992, Nature 355:850-852; U.S. Pat. No. 5,096,815, U.S. Pat. No. 5,223,409, and U.S. Pat. No. 5,198,346, all to Ladner et al.; Rebar and Pabo, 1993, Science 263:671-673; and CT Publication No. WO 94/18318.

[0879] In a specific embodiment, screening to identify a molecule that binds reproductive system related antigen polypeptides can be carried out by contacting the library members with a reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides immobilized on a solid phase and harvesting those library members that bind to the reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides. Examples of such screening methods, termed “panning” techniques are described by way of example in Parmley and Smith, 1988, Gene 73:305-318; Fowlkes et al., 1992, BioTechniques 13:422-427; International Publication No. WO 94/18318; and in references cited herein.

[0880] In another embodiment, the two-hybrid system for selecting interacting proteins in yeast (Fields and Song, 1989, Nature 340:245-246; Chien et al., 1991, Proc. Natl. Acad. Sci. USA 88:9578-9582) can be used to identify molecules that specifically bind to reproductive system related antigen polypeptides or reproductive system related antigen-like polypeptides.

[0881] Where the reproductive system related antigen binding molecule is a polypeptide, the polypeptide can be conveniently selected from any peptide library, including random peptide libraries, combinatorial peptide libraries, or biased peptide libraries. The term “biased” is used herein to mean that the method of generating the library is manipulated so as to restrict one or more parameters that govern the diversity of the resulting collection of molecules, in this case peptides.

[0882] Thus, a truly random peptide library would generate a collection of peptides in which the probability of finding a particular amino acid at a given position of the peptide is the same for all 20 amino acids. A bias can be introduced into the library, however, by specifying, for example, that a lysine occur every fifth amino acid or that positions 4, 8, and 9 of a decapeptide library be fixed to include only arginine. Clearly, many types of biases can be contemplated, and the present invention is not restricted to any particular bias. Furthermore, the present invention contemplates specific types of peptide libraries, such as phage displayed peptide libraries and those that utilize a DNA construct comprising a lambda phage vector with a DNA insert.

[0883] As mentioned above, in the case of a reproductive system related antigen binding molecule that is a polypeptide, the polypeptide may have about 6 to less than about 60 amino acid residues, preferably about 6 to about 10 amino acid residues, and most preferably, about 6 to about 22 amino acids. In another embodiment, a reproductive system related antigen binding polypeptide has in the range of 15-100 amino acids, or 20-50 amino acids.

[0884] The selected reproductive system related antigen binding polypeptide can be obtained by chemical synthesis or recombinant expression.

[0885] Other Activities

[0886] A polypeptide, polynucleotide, agonist, or antagonist of the present invention, as a result of the ability to stimulate vascular endothelial cell growth, may be employed in treatment for stimulating re-vascularization of ischemic tissues due to various disease conditions such as thrombosis, arteriosclerosis, and other cardiovascular conditions. The polypeptide, polynucleotide, agonist, or antagonist of the present invention may also be employed to stimulate angiogenesis and limb regeneration, as discussed above.

[0887] A polypeptide, polynucleotide, agonist, or antagonist of the present invention may also be employed for treating wounds due to injuries, burns, post-operative tissue repair, and ulcers since they are mitogenic to various cells of different origins, such as fibroblast cells and skeletal muscle cells, and therefore, facilitate the repair or replacement of damaged or diseased tissue.

[0888] A polypeptide, polynucleotide, agonist, or antagonist of the present invention may also be employed to stimulate neuronal growth and to treat and prevent neuronal damage which occurs in certain neuronal disorders or neuro-degenerative conditions such as Alzheimer's disease, Parkinson's disease, and AIDS-related complex. A polypeptide, polynucleotide, agonist, or antagonist of the present invention may have the ability to stimulate chondrocyte growth, therefore, they may be employed to enhance bone and periodontal regeneration and aid in tissue transplants or bone grafts.

[0889] A polypeptide, polynucleotide, agonist, or antagonist of the present invention may be also be employed to prevent skin aging due to sunburn by stimulating keratinocyte growth.

[0890] A polypeptide, polynucleotide, agonist, or antagonist of the present invention may also be employed for preventing hair loss, since FGF family members activate hair-forming cells and promotes melanocyte growth. Along the same lines, a polypeptide, polynucleotide, agonist, or antagonist of the present invention may be employed to stimulate growth and differentiation of hematopoietic cells and bone marrow cells when used in combination with other cytokines.

[0891] A polypeptide, polynucleotide, agonist, or antagonist of the present invention may also be employed to maintain organs before transplantation or for supporting cell culture of primary tissues. A polypeptide, polynucleotide, agonist, or antagonist of the present invention may also be employed for inducing tissue of mesodermal origin to differentiate in early embryos.

[0892] A polypeptide, polynucleotide, agonist, or antagonist of the present invention may also increase or decrease the differentiation or proliferation of embryonic stem cells, besides, as discussed above, hematopoietic lineage.

[0893] A polypeptide, polynucleotide, agonist, or antagonist of the present invention may also be used to modulate mammalian characteristics, such as body height, weight, hair color, eye color, skin, percentage of adipose tissue, pigmentation, size, and shape (e.g., cosmetic surgery). Similarly, a polypeptide, polynucleotide, agonist, or antagonist of the present invention may be used to modulate mammalian metabolism affecting catabolism, anabolism, processing, utilization, and storage of energy.

[0894] A polypeptide, polynucleotide, agonist, or antagonist of the present invention may be used to change a mammal's mental state or physical state by influencing biorhythms, caricadic rhythms, depression (including depressive disorders), tendency for violence, tolerance for pain, reproductive capabilities (preferably by Activin or Inhibin-like activity), hormonal or endocrine levels, appetite, libido, memory, stress, or other cognitive qualities.

[0895] A polypeptide, polynucleotide, agonist, or antagonist of the present invention may also be used as a food additive or preservative, such as to increase or decrease storage capabilities, fat content, lipid, protein, carbohydrate, vitamins, minerals, cofactors or other nutritional components.

[0896] The above-recited applications have uses in a wide variety of hosts. Such hosts include, but are not limited to, human, murine, rabbit, goat, guinea pig, camel, horse, mouse, rat, hamster, pig, micro-pig, chicken, goat, cow, sheep, dog, cat, non-human primate, and human. In specific embodiments, the host is a mouse, rabbit, goat, guinea pig, chicken, rat, hamster, pig, sheep, dog or cat. In preferred embodiments, the host is a mammal. In most preferred embodiments, the host is a human.

[0897] Other Preferred Embodiments

[0898] Other preferred embodiments of the claimed invention include an isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to a sequence of at least about 50 contiguous nucleotides in the nucleotide sequence of SEQ ID NO: X or the complementary strand thereto, the nucleotide sequence as defined in column 4 of Table 1A or columns 8 and 9 of Table 2 or the complementary strand thereto, and/or cDNA contained in Clone ID NO: Z.

[0899] Also preferred is a nucleic acid molecule wherein said sequence of contiguous nucleotides is included in the nucleotide sequence of the portion of SEQ ID NO: X as defined in column 4, “ORF (From-To)”, in Table 1A.

[0900] Also preferred is a nucleic acid molecule wherein said sequence of contiguous nucleotides is included in the nucleotide sequence of the portion of SEQ ID NO: X as defined in columns 8 and 9, “NT From” and “NT To” respectively, in Table 2.

[0901] Also preferred is an isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to a sequence of at least about 150 contiguous nucleotides in the nucleotide sequence of SEQ ID NO: X or the complementary strand thereto, the nucleotide sequence as defined in column 4 of Table 1A or columns 8 and 9 of Table 2 or the complementary strand thereto, and/or cDNA contained in Clone ID NO: Z.

[0902] Further preferred is an isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to a sequence of at least about 500 contiguous nucleotides in the nucleotide sequence of SEQ ID NO: X or the complementary strand thereto, the nucleotide sequence as defined in column 4 of Table 1A or columns 8 and 9 of Table 2 or the complementary strand thereto, and/or cDNA contained in Clone ID NO: Z.

[0903] A further preferred embodiment is a nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to the nucleotide sequence of the portion of SEQ ID NO: X defined in column 4, “ORF (From-To)”, in Table 1A.

[0904] A further preferred embodiment is a nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to the nucleotide sequence of the portion of SEQ ID NO: X defined in columns 8 and 9, “NT From” and “NT To”, respectively, in Table 2.

[0905] A further preferred embodiment is an isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to the complete nucleotide sequence of SEQ ID NO: X or the complementary strand thereto, the nucleotide sequence as defined in column 4 of Table 1A or columns 8 and 9 of Table 2 or the complementary strand thereto, and/or cDNA contained in Clone ID NO: Z.

[0906] Also preferred is an isolated nucleic acid molecule which hybridizes under stringent hybridization conditions to a nucleic acid molecule comprising a nucleotide sequence of SEQ ID NO: X or the complementary strand thereto, the nucleotide sequence as defined in column 4 of Table 1A or columns 8 and 9 of Table 2 or the complementary strand thereto, and/or cDNA contained in Clone ID NO: Z, wherein said nucleic acid molecule which hybridizes does not hybridize under stringent hybridization conditions to a nucleic acid molecule having a nucleotide sequence consisting of only A residues or of only T residues.

[0907] Also preferred is a composition of matter comprising a DNA molecule which comprises the cDNA contained in Clone ID NO: Z.

[0908] Also preferred is an isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to a sequence of at least 50 contiguous nucleotides of the cDNA sequence contained in Clone ID NO: Z.

[0909] Also preferred is an isolated nucleic acid molecule, wherein said sequence of at least 50 contiguous nucleotides is included in the nucleotide sequence of an open reading frame sequence encoded by cDNA contained in Clone ID NO: Z.

[0910] Also preferred is an isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to sequence of at least 150 contiguous nucleotides in the nucleotide sequence encoded by cDNA contained in Clone ID NO: Z.

[0911] A further preferred embodiment is an isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to sequence of at least 500 contiguous nucleotides in the nucleotide sequence encoded by cDNA contained in Clone ID NO: Z.

[0912] A further preferred embodiment is an isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to the complete nucleotide sequence encoded by cDNA contained in Clone ID NO: Z.

[0913] A further preferred embodiment is a method for detecting in a biological sample a nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to a sequence of at least 50 contiguous nucleotides in a sequence selected from the group consisting of: a nucleotide sequence of SEQ ID NO: X or the complementary strand thereto; the nucleotide sequence as defined in column 4 of Table 1A or columns 8 and 9 of Table 2 or the complementary strand thereto; and a nucleotide sequence encoded by cDNA contained in Clone ID NO: Z; which method comprises a step of comparing a nucleotide sequence of at least one nucleic acid molecule in said sample with a sequence selected from said group and determining whether the sequence of said nucleic acid molecule in said sample is at least 95% identical to said selected sequence.

[0914] Also preferred is the above method wherein said step of comparing sequences comprises determining the extent of nucleic acid hybridization between nucleic acid molecules in said sample and a nucleic acid molecule comprising said sequence selected from said group. Similarly, also preferred is the above method wherein said step of comparing sequences is performed by comparing the nucleotide sequence determined from a nucleic acid molecule in said sample with said sequence selected from said group. The nucleic acid molecules can comprise DNA molecules or RNA molecules.

[0915] A further preferred embodiment is a method for identifying the species, tissue or cell type of a biological sample which method comprises a step of detecting nucleic acid molecules in said sample, if any, comprising a nucleotide sequence that is at least 95% identical to a sequence of at least 50 contiguous nucleotides in a sequence selected from the group consisting of: a nucleotide sequence of SEQ ID NO: X or the complementary strand thereto; the nucleotide sequence as defined in column 4 of Table 1A or columns 8 and 9 of Table 2 or the complementary strand thereto; and a nucleotide sequence of the cDNA contained in Clone ID NO: Z.

[0916] The method for identifying the species, tissue or cell type of a biological sample can comprise a step of detecting nucleic acid molecules comprising a nucleotide sequence in a panel of at least two nucleotide sequences, wherein at least one sequence in said panel is at least 95% identical to a sequence of at least 50 contiguous nucleotides in a sequence selected from said group.

[0917] Also preferred is a method for diagnosing in a subject a pathological condition associated with abnormal structure or expression of a nucleotide sequence of SEQ ID NO: X or the complementary strand thereto; the nucleotide sequence as defined in column 4 of Table 1A or columns 8 and 9 of Table 2 or the complementary strand thereto; or the cDNA contained in Clone ID NO: Z which encodes a protein, wherein the method comprises a step of detecting in a biological sample obtained from said subject nucleic acid molecules, if any, comprising a nucleotide sequence that is at least 95% identical to a sequence of at least 50 contiguous nucleotides in a sequence selected from the group consisting of: a nucleotide sequence of SEQ ID NO: X or the complementary strand thereto; the nucleotide sequence as defined in column 4 of Table 1A or columns 8 and 9 of Table 2 or the complementary strand thereto; and a nucleotide sequence of cDNA contained in Clone ID NO: Z.

[0918] The method for diagnosing a pathological condition can comprise a step of detecting nucleic acid molecules comprising a nucleotide sequence in a panel of at least two nucleotide sequences, wherein at least one sequence in said panel is at least 95% identical to a sequence of at least 50 contiguous nucleotides in a sequence selected from said group.

[0919] Also preferred is a composition of matter comprising isolated nucleic acid molecules wherein the nucleotide sequences of said nucleic acid molecules comprise a panel of at least two nucleotide sequences, wherein at least one sequence in said panel is at least 95% identical to a sequence of at least 50 contiguous nucleotides in a sequence selected from the group consisting of: a nucleotide sequence of SEQ ID NO: X or the complementary strand thereto; the nucleotide sequence as defined in column 4 of Table 1A or columns 8 and 9 of Table 2 or the complementary strand thereto; and a nucleotide sequence encoded by cDNA contained in Clone ID NO: Z.

[0920] The nucleic acid molecules can comprise DNA molecules or RNA molecules.

[0921] Also preferred is a composition of matter comprising isolated nucleic acid molecules wherein the nucleotide sequences of said nucleic acid molecules comprise a DNA microarray or “chip” of at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 40, 50, 100, 150, 200, 250, 300, 500, 1000, 2000, 3000, or 4000 nucleotide sequences, wherein at least one sequence in said DNA microarray or “chip” is at least 95% identical to a sequence of at least 50 contiguous nucleotides in a sequence selected from the group consisting of: a nucleotide sequence of SEQ ID NO: X wherein X is any integer as defined in Table 1A; and a nucleotide sequence encoded by a human cDNA clone identified by a cDNA “Clone ID” in Table 1A.

[0922] Also preferred is an isolated polypeptide comprising an amino acid sequence at least 90% identical to a sequence of at least about 10 contiguous amino acids in the polypeptide sequence of SEQ ID NO: Y; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and/or a polypeptide encoded by cDNA contained in Clone ID NO: Z.

[0923] Also preferred is an isolated polypeptide comprising an amino acid sequence at least 95% identical to a sequence of at least about 30 contiguous amino acids in the amino acid sequence of SEQ ID NO: Y; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and/or a polypeptide encoded by cDNA contained in Clone ID NO: Z.

[0924] Further preferred is an isolated polypeptide comprising an amino acid sequence at least 95% identical to a sequence of at least about 100 contiguous amino acids in the amino acid sequence of SEQ ID NO: Y; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and/or a polypeptide encoded by cDNA contained in Clone ID NO: Z.

[0925] Further preferred is an isolated polypeptide comprising an amino acid sequence at least 95% identical to the complete amino acid sequence of SEQ ID NO: Y; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and/or a polypeptide encoded by cDNA contained in Clone ID NO: Z.

[0926] Further preferred is an isolated polypeptide comprising an amino acid sequence at least 90% identical to a sequence of at least about 10 contiguous amino acids in the complete amino acid sequence of a polypeptide encoded by contained in Clone ID NO: Z

[0927] Also preferred is a polypeptide wherein said sequence of contiguous amino acids is included in the amino acid sequence of a portion of said polypeptide encoded by cDNA contained in Clone ID NO: Z; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and/or the polypeptide sequence of SEQ ID NO: Y.

[0928] Also preferred is an isolated polypeptide comprising an amino acid sequence at least 95% identical to a sequence of at least about 30 contiguous amino acids in the amino acid sequence of a polypeptide encoded by the cDNA contained in Clone ID NO: Z.

[0929] Also preferred is an isolated polypeptide comprising an amino acid sequence at least 95% identical to a sequence of at least about 100 contiguous amino acids in the amino acid sequence of a polypeptide encoded by cDNA contained in Clone ID NO: Z.

[0930] Also preferred is an isolated polypeptide comprising an amino acid sequence at least 95% identical to the amino acid sequence of a polypeptide encoded by the cDNA contained in Clone ID NO: Z.

[0931] Further preferred is an isolated antibody which binds specifically to a polypeptide comprising an amino acid sequence that is at least 90% identical to a sequence of at least 10 contiguous amino acids in a sequence selected from the group consisting of: a polypeptide sequence of SEQ ID NO: Y; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and a polypeptide encoded by the cDNA contained in Clone ID NO: Z.

[0932] Further preferred is a method for detecting in a biological sample a polypeptide comprising an amino acid sequence which is at least 90% identical to a sequence of at least 10 contiguous amino acids in a sequence selected from the group consisting of: a polypeptide sequence of SEQ ID NO: Y; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and a polypeptide encoded by the cDNA contained in Clone ID NO: Z; which method comprises a step of comparing an amino acid sequence of at least one polypeptide molecule in said sample with a sequence selected from said group and determining whether the sequence of said polypeptide molecule in said sample is at least 90% identical to said sequence of at least 10 contiguous amino acids.

[0933] Also preferred is the above method wherein said step of comparing an amino acid sequence of at least one polypeptide molecule in said sample with a sequence selected from said group comprises determining the extent of specific binding of polypeptides in said sample to an antibody which binds specifically to a polypeptide comprising an amino acid sequence that is at least 90% identical to a sequence of at least 10 contiguous amino acids in a sequence selected from the group consisting of: a polypeptide sequence of SEQ ID NO: Y; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and a polypeptide encoded by the cDNA contained in Clone ID NO: Z.

[0934] Also preferred is the above method wherein said step of comparing sequences is performed by comparing the amino acid sequence determined from a polypeptide molecule in said sample with said sequence selected from said group.

[0935] Also preferred is a method for identifying the species, tissue or cell type of a biological sample which method comprises a step of detecting polypeptide molecules in said sample, if any, comprising an amino acid sequence that is at least 90% identical to a sequence of at least 10 contiguous amino acids in a sequence selected from the group consisting of: polypeptide sequence of SEQ ID NO: Y; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and a polypeptide encoded by the cDNA contained in Clone ID NO: Z.

[0936] Also preferred is the above method for identifying the species, tissue or cell type of a biological sample, which method comprises a step of detecting polypeptide molecules comprising an amino acid sequence in a panel of at least two amino acid sequences, wherein at least one sequence in said panel is at least 90% identical to a sequence of at least 10 contiguous amino acids in a sequence selected from the above group.

[0937] Also preferred is a method for diagnosing in a subject a pathological condition associated with abnormal structure or expression of a nucleic acid sequence identified in Table 1A or Table 2 encoding a polypeptide, which method comprises a step of detecting in a biological sample obtained from said subject polypeptide molecules comprising an amino acid sequence in a panel of at least two amino acid sequences, wherein at least one sequence in said panel is at least 90% identical to a sequence of at least 10 contiguous amino acids in a sequence selected from the group consisting of: polypeptide sequence of SEQ ID NO: Y; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and a polypeptide encoded by the cDNA contained in Clone ID NO: Z.

[0938] In any of these methods, the step of detecting said polypeptide molecules includes using an antibody.

[0939] Also preferred is an isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to a nucleotide sequence encoding a polypeptide wherein said polypeptide comprises an amino acid sequence that is at least 90% identical to a sequence of at least 10 contiguous amino acids in a sequence selected from the group consisting of: polypeptide sequence of SEQ ID NO: Y; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and a polypeptide encoded by the cDNA contained in Clone ID NO: Z.

[0940] Also preferred is an isolated nucleic acid molecule, wherein said nucleotide sequence encoding a polypeptide has been optimized for expression of said polypeptide in a prokaryotic host.

[0941] Also preferred is a polypeptide molecule, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of: polypeptide sequence of SEQ ID NO: Y; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and a polypeptide encoded by the cDNA contained in Clone ID NO: Z.

[0942] Further preferred is a method of making a recombinant vector comprising inserting any of the above isolated nucleic acid molecule into a vector. Also preferred is the recombinant vector produced by this method. Also preferred is a method of making a recombinant host cell comprising introducing the vector into a host cell, as well as the recombinant host cell produced by this method.

[0943] Also preferred is a method of making an isolated polypeptide comprising culturing this recombinant host cell under conditions such that said polypeptide is expressed and recovering said polypeptide. Also preferred is this method of making an isolated polypeptide, wherein said recombinant host cell is a eukaryotic cell and said polypeptide is a human protein comprising an amino acid sequence selected from the group consisting of: polypeptide sequence of SEQ ID NO: Y; a polypeptide encoded by SEQ ID NO: X or the complementary strand thereto; the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2; and a polypeptide encoded by the cDNA contained in Clone ID NO: Z. The isolated polypeptide produced by this method is also preferred.

[0944] Also preferred is a method of treatment of an individual in need of an increased level of a protein activity, which method comprises administering to such an individual a Therapeutic comprising an amount of an isolated polypeptide, polynucleotide, immunogenic fragment or analogue thereof, binding agent, antibody, or antigen binding fragment of the claimed invention effective to increase the level of said protein activity in said individual.

[0945] Also preferred is a method of treatment of an individual in need of a decreased level of a protein activity, which method comprised administering to such an individual a Therapeutic comprising an amount of an isolated polypeptide, polynucleotide, immunogenic fragment or analogue thereof, binding agent, antibody, or antigen binding fragment of the claimed invention effective to decrease the level of said protein activity in said individual.

[0946] Also preferred is a method of treatment of an individual in need of a specific delivery of toxic compositions to diseased cells (e.g., tumors, leukemias or lymphomas), which method comprises administering to such an individual a Therapeutic comprising an amount of an isolated polypeptide of the invention, including, but not limited to a binding agent, or antibody of the claimed invention that are associated with toxin or cytotoxic prodrugs.

[0947] Having generally described the invention, the same will be more readily understood by reference to the following examples, which are provided by way of illustration and are not intended as limiting. TABLE 6 ATCC Deposits Deposit Date ATCC Designation Number LP01, LP02, LP03, May 20,1997 209059, 209060, 209061, 209062, LP04, LP05, LP06, 209063, 209064, 209065, 209066, LP07, LP08, LP09, 209067, 209068, 209069 LP10, LP11, LP12 Jan. 12,1998 209579 LP13 Jan. 12,1998 209578 LP14 Jul. 16,1998 203067 LP15 Jul. 16,1998 203068 LP16 Feb. 1,1999 203609 LP17 Feb. 1,1999 203610 LP20 Nov. 17,1998 203485 LP21 Jun. 18,1999 PTA-252 LP22 Jun. 18,1999 PTA-253 LP23 Dec. 22,1999 PTA-1081

EXAMPLES Example 1 Isolation of a Selected cDNA Clone from the Deposited Sample

[0948] Each Clone ID NO: Z is contained in a plasmid. Table 7 identifies the vectors used to construct the cDNA library from which each clone was isolated. In many cases, the vector used to construct the library is a phage vector from which a plasmid has been excised. The following correlates the related plasmid for each phage vector used in constructing the cDNA library. For example, where a particular clone is identified in Table 7 as being isolated in the vector “Lambda Zap,” the corresponding deposited clone is in “pBluescript.” Vector Used to Corresponding Construct Library Deposited Plasmid Lambda Zap pBluescript (pBS) Uni-Zap XR pBluescript (pBS) Zap Express pBK lafmid BA plafmid BA pSportl pSportl pCMVSport 2.0 pCMVSport 2.0 pCMVSport 3.0 pCMVSport 3.0 pCR ® 2.1 pCR ® 2.1

[0949] Vectors Lambda Zap (U.S. Pat. Nos. 5,128,256 and 5,286,636), Uni-Zap XR (U.S. Pat. Nos. 5,128, 256 and 5,286,636), Zap Express (U.S. Pat. Nos. 5,128,256 and 5,286,636), pBluescript (pBS) (Short, J. M. et al., Nucleic Acids Res. 16:7583-7600 (1988); Alting-Mees, M. A. and Short, J. M., Nucleic Acids Res. 17:9494 (1989)) and pBK (Alting-Mees, M. A. et al., Strategies 5:58-61 (1992)) are commercially available from Stratagene Cloning Systems, Inc., 11011 N. Torrey Pines Road, La Jolla, Calif., 92037. pBS contains an ampicillin resistance gene and pBK contains a neomycin resistance gene. Both can be transformed into E. coli strain XL-1 Blue, also available from Stratagene. pBS comes in 4 forms SK+, SK−, KS+ and KS. The S and K refers to the orientation of the polylinker to the T7 and T3 primer sequences which flank the polylinker region (“S” is for SacI and “K” is for KpnI which are the first sites on each respective end of the linker). “+” or “−” refer to the orientation of the f1 origin of replication (“ori”), such that in one orientation, single stranded rescue initiated from the f1 ori generates sense strand DNA and in the other, antisense.

[0950] Vectors pSport1, pCMVSport 2.0 and pCMVSport 3.0, were obtained from Life Technologies, Inc., P. O. Box 6009, Gaithersburg, Md. 20897. All Sport vectors contain an ampicillin resistance gene and may be transformed into E. coli strain DH10B, also available from Life Technologies. (See, for instance, Gruber, C. E., et al., Focus 15:59 (1993).) Vector lafmid BA (Bento Soares, Columbia University, NY) contains an ampicillin resistance gene and can be transformed into E. coli strain XL-1 Blue. Vector pCR®2.1, which is available from Invitrogen, 1600 Faraday Avenue, Carlsbad, Calif. 92008, contains an ampicillin resistance gene and may be transformed into E. coli strain DH10B, available from Life Technologies. (See, for instance, Clark, J. M., Nuc. Acids Res. 16:9677-9686 (1988) and Mead, D. et al., Bio/Technology 9: (1991).) Preferably, a polynucleotide of the present invention does not comprise the vector sequences identified for the particular clone in Table 7, as well as the corresponding plasmid vector sequences designated above.

[0951] The deposited material in the sample assigned the ATCC Deposit Number cited by reference to Tables 1A, 2, 6 and 7 for any given cDNA clone also may contain one or more additional plasmids, each comprising a cDNA clone different from that given clone. Thus, deposits sharing the same ATCC Deposit Number contain at least a plasmid for each Clone ID NO: Z. TABLE 7 Libraries owned Catalog ATCC by Catalog Description Vector Deposit HUKA HUKB HUKC HUKD Human Uterine Lambda LP01 HUKE HUKF HUKG Cancer ZAP II HCNA HCNB Human Colon Lambda Zap II LP01 HFFA Human Fetal Brain, Lambda Zap II LP01 random primed HTWA Resting T-Cell Lambda ZAP II LP01 HBQA Early Stage Lambda ZAP II LP01 Human Brain, random primed HLMB HLMF HLMG HLMH breast lymph node Lambda ZAP II LP01 HLMI HLMJ HLMM HLMN CDNA library HCQA HCQB human colon cancer Lamda ZAP II LP01 HMEA HMEC HMED HMEE Human Microvascular Lambda ZAP II LP01 HMEF HMEG HMEI HMEJ Endothelial HMEK HMEL Cells, fract. A HUSA HUSC Human Umbilical Lambda ZAP II LP01 Vein Endothelial Cells, fract. A HLQA HLQB Hepatocellular Tumor Lambda ZAP II LP01 HHGA HHGB HHGC HHGD Hemangiopericytoma Lambda ZAP II LP01 HSDM Human Striatum Lambda ZAP II LP01 Depression, re-rescue HUSH H Umbilical Vein Lambda ZAP II LP01 Endothelial Cells, frac A, re-excision HSGS Salivary gland, Lambda ZAP II LP01 subtracted HFXA HFXB HFXC HFXD Brain frontal Lambda ZAP II LP01 HFXE HFXF HFXG HFXH cortex HPQA HPQB HPQC PERM TF274 Lambda ZAP II LP01 HFXJ HFXK Brain Frontal Lambda ZAP II LP01 Cortex, re-excision HCWA HCWB HCWC HCWD CD34 positive ZAP Express LP02 HCWE HCWF HCWG HCWH cells (Cord HCWI HCWJ HCWK Blood) HCUA HCUB HCUC CD34 depleted Buffy ZAP Express LP02 Coat (Cord Blood) HRSM A-14 cell line ZAP Express LP02 HRSA A1-CELL LINE ZAP Express LP02 HCUD HCUE HCUF HCUG CD34 depleted Buffy ZAP Express LP02 HCUH HCUI Coat (Cord Blood), re-excision HBXE HBXF HBXG H. Whole Brain ZAP Express LP02 #2, re-excision HRLM L8 cell line ZAP Express LP02 HBXA HBXB HBXC HBXD Human Whole Brain ZAP Express LP02 #2-Oligo dT > 1.5Kb HUDA HUDB HUDC Testes ZAP Express LP02 HHTM HHTN HHTO H. hypothalamus, frac ZAP Express LP02 A; re-excision HHTL H. hypothalamus, frac A ZAP Express LP02 HASA HASD Human Adult Spleen Uni-ZAP XR LP03 HFKC HFKD HFKE HFKF Human Fetal Kidney Uni-ZAP XR LP03 HFKG HE8A HE8B HE8C HE8D Human 8 Week Uni-ZAP XR LP03 HE8E HE8F HE8M HE8N Whole Embryo HGBA HGBD HGBE HGBF Human Gall Bladder Uni-ZAP XR LP03 HGBG HGBH HGBI HLHA HLHB HLHC HLHD Human Fetal Lung Uni-ZAP XR LP03 HLHE HLHF HLHG HLHH III HLHQ HPMA HPMB HPMC HPMD Human Placenta Uni-ZAP XR LP03 HPME HPMF HPMG HPMH HPRA HPRB HPRC HPRD Human Prostate Uni-ZAP XR LP03 HSIA HSIC HSID HSIE Human Adult Uni-ZAP XR LP03 Small Intestine HTEA HTEB HTEC HTED Human Testes Uni-ZAP XR LP03 HTEE HTEF HTEG HTEH HTEI HTEJ HTEK HTPA HTPB HTPC HTPD Human Pancreas Uni-ZAP XR LP03 HTPE Tumor HTTA HTTB HTTC HTTD Human Testes Tumor Uni-ZAP XR LP03 HTTE HTTF HAPA HAPB HAPC HAPM Human Adult Pulmonary Uni-ZAP XR LP03 HETA HETB HETC HETD Human Endometrial Tumor Uni-ZAP XR LP03 HETE HETF HETG HETH HETI HHFB HHFC HHFD HHFE Human Fetal Heart Uni-ZAP XR LP03 HHFF HHFG HHFH HHFI HHPB HHPC HHPD HHPE Human Hippocampus Uni-ZAP XR LP03 HHPF HHPG HHPH HCE1 HCE2 HCE3 HCE4 Human Cerebellum Uni-ZAP XR LP03 HCE5 HCEB HCEC HCED HCEE HCEF HCEG HUVB HUVC HUVD HUVE Human Umbilical Vein, Uni-ZAP XR LP03 Endo. remake HSTA HSTB HSTC HSTD Human Skin Tumor Uni-ZAP XR LP03 HTAA HTAB HTAC HTAD Human Activated T-Cells Uni-ZAP XR LP03 HTAE HFEA HFEB HFEC Human Fetal Uni-ZAP XR LP03 Epithelium (Skin) HJPA HJPB HJPC HJPD HUMAN JURKAT Uni-ZAP XR LP03 MEMBRANE BOUND POLYSOMES HESA Human epithelioid sarcoma Uni-Zap XR LP03 HLTA HLTB HLTC HLTD Human T-Cell Uni-ZAP XR LP03 HLTE HLTF Lymphoma HFTA HFTB HFTC HFTD Human Fetal Dura Mater Uni-ZAP XR LP03 HRDA HRDB HRDC HRDD Human Rhabdo- Uni-ZAP XR LP03 HRDE HRDF myosarcoma HCAA HCAB HCAC Cem cells cyclo- Uni-ZAP XR LP03 hexamide treated HRGA HRGB HRGC HRGD Raji Cells, cyclo- Uni-ZAP XR LP03 hexamide treated HSUA HSUB HSUC HSUM Supt Cells, cyclo- Uni-ZAP XR LP03 hexamide treated HT4A HT4C HT4D Activated T-Cells, 12 hrs. Uni-ZAP XR LP03 HE9A HE9B HE9C HE9D Nine Week Old Uni-ZAP XR LP03 HE9E HE9F HE9G HE9H Early Stage Human HE9M HE9N HATA HATB HATC HATD Human Adrenal Uni-ZAP XR LP03 HATE Gland Tumor HT5A Activated T-Cells, 24 hrs. Uni-ZAP XR LP03 HFGA HFGM Human Fetal Brain Uni-ZAP XR LP03 HNEA HNEB HNEC HNED Human Neutrophil Uni-ZAP XR LP03 HNEE HBGB HBGD Human Primary Uni-ZAP XR LP03 Breast Cancer HBNA HBNB Human Normal Breast Uni-ZAP XR LP03 HCAS Cem Cells, cyclo- Uni-ZAP XR LP03 hexamide treated, subtra HHPS Human Hippocampus, pBS LP03 subtracted HKCS HKCU Human Colon Cancer, pBS LP03 subtracted HRGS Raji cells, cyclo- pBS LP03 hexamide treated, subtracted HSUT Supt cells, cyclo- pBS LP03 hexamide treated, differentially expressed HT4S Activated T-Cells, Uni-ZAP XR LP03 12 hrs, subtracted HCDA HCDB HCDC HCDD Human Chondrosarcoma Uni-ZAP XR LP03 HCDE HOAA HOAB HOAC Human Osteosarcoma Uni-ZAP XR LP03 HTLA HTLB HTLC HTLD Human adult testis, Uni-ZAP XR LP03 HTLE HTLF large inserts HLMA HLMC HLMD Breast Lymph node Uni-ZAP XR LP03 cDNA library H6EA H6EB H6EC HL-60, PMA 4H Uni-ZAP XR LP03 HTXA HTXB HTXC HTXD Activated T-Cell Uni-ZAP XR LP03 HTXE HTXF HTXG HTXH (12 hs)/Thiouridine labelledEco HNFA HNFB HNFC HNFD Human Neutrophil, Uni-ZAP XR LP03 HNFE HNFF HNFG HNFH Activated HNFJ HTOB HTOC HUMAN TONSILS, Uni-ZAP XR LP03 FRACTION 2 HMGB Human OB MG63 Uni-ZAP XR LP03 control fraction I HOPB Human OB HOS Uni-ZAP XR LP03 control fraction I HORB Human OB HOS Uni-ZAP XR LP03 treated (10 nM E2) fraction I HSVA HSVB HSVC Human Chronic Synovitis Uni-ZAP XR LP03 HROA HUMAN STOMACH Uni-ZAP XR LP03 HBJA HBJB HBJC HBJD HUMAN B CELL Uni-ZAP XR LP03 HBJE HBJF HBJG HBJH LYMPHOMA HBJI HBJJ HBJK HCRA HCRB HCRC human corpus colosum Uni-ZAP XR LP03 HODA HODB HODC HODD human ovarian cancer Uni-ZAP XR LP03 HDSA Dermatofibrosarcoma Uni-ZAP XR LP03 Protuberance HMWA HMWB HMWC Bone Marrow Uni-ZAP XR LP03 HMWD HMWE HMWF Cell Line (RS4;11) HMWG HMWH HMWI HMWJ HSOA stomach cancer (human) Uni-ZAP XR LP03 HERA SKIN Uni-ZAP XR LP03 HMDA Brain-medulloblastoma Uni-ZAP XR LP03 HGLA HGLB HGLD Glioblastoma Uni-ZAP XR LP03 HEAA H. Atrophic Endometrium Uni-ZAP XR LP03 HBCA HBCB H. Lymph node Uni-ZAP XR LP03 breast Cancer HPWT Human Prostate Uni-ZAP XR LP03 BPH, re-excision HFVG HFVH HFVI Fetal Liver, pBS LP03 subtraction II HNFI Human Neutrophils, pBS LP03 Activated, re-excision HBMB HBMC HBMD Human Bone Marrow, pBS LP03 re-excision HKML HKMM HKMN H. Kidney Medulla, pBS LP03 re-excision HKIX HKIY H. Kidney Cortex, pBS LP03 subtracted HADT H. Amygdala Depression, pBS LP03 subtracted H6AS H1-60, untreated, Uni-ZAP XR LP03 subtracted H6ES HL-60, PMA 4H, Uni-ZAP XR LP03 subtracted H6BS HL-60, RA 4h, Uni-ZAP XR LP03 Subtracted H6CS HL-60, PMA 1d, Uni-ZAP XR LP03 subtracted HTXJ HTXK Activated T-cell (12 h)/ Uni-ZAP XR LP03 Thiouridine-re-excision HMSA HMSB HMSC HMSD Monocyte activated Uni-ZAP XR LP03 HMSE HMSF HMSG HMSH HMSI HMSJ HMSK HAGA HAGB HAGC HAGD Human Amygdala Uni-ZAP XR LP03 HAGE HAGF HSRA HSRB HSRE STROMAL-OSTEO- Uni-ZAP XR LP03 CLASTOMA HSRD HSRF HSRG HSRH Human Osteoclastoma Uni-ZAP XR LP03 Stromal Cells- unamplified HSQA HSQB HSQC HSQD Stromal cell TF274 Uni-ZAP XR LP03 HSQE HSQF HSQG HSKA HSKB HSKC HSKD Smooth muscle, Uni-ZAP XR LP03 HSKE HSKF HSKZ serum treated HSLA HSLB HSLC HSLD Smooth muscle, control Uni-ZAP XR LP03 HSLE HSLF HSLG HSDA HSDD HSDE HSDF Spinal cord Uni-ZAP XR LP03 HSDG HSDH HPWS Prostate-BPH pBS LP03 subtracted II HSKW HSKX HSKY Smooth Muscle- pBS LP03 HASTE normalized HFPB HFPC HFPD H. Frontal cortex, Uni-ZAP XR LP03 epileptic; re-excision HSDI HSDJ HSDK Spinal Cord, re-excision Uni-ZAP XR LP03 HSKN HSKO Smooth Muscle Serum pBS LP03 Treated, Norm HSKG HSKH HSKI Smooth muscle, serum pBS LP03 induced, re-exc HFCA HFCB HFCC HFCD Human Fetal Brain Uni-ZAP XR LP04 HFCE HFCF HPTA HPTB HPTD Human Pituitary Uni-ZAP XR LP04 HTHB HTHC HTHD Human Thymus Uni-ZAP XR LP04 HE6B HE6C HE6D HE6E Human Whole Six Uni-ZAP XR LP04 HE6F HE6G HE6S Week Old Embryo HSSA HSSB HSSC HSSD Human Synovial Sarcoma Uni-ZAP XR LP04 HSSE HSSF HSSG HSSH HSSI HSSJ HSSK HE7T 7 Week Old Early Uni-ZAP XR LP04 Stage Human, subtracted HEPA HEPB HEPC Human Epididymus Uni-ZAP XR LP04 HSNA HSNB HSNC HSNM Human Synovium Uni-ZAP XR LP04 HSNN HPFB HPFC HPFD HPFE Human Prostate Uni-ZAP XR LP04 Cancer, Stage C fraction HE2A HE2D HE2E HE2H 12 Week Old Early Uni-ZAP XR LP04 HE2I HE2M HE2N HE2O Stage Human HE2B HE2C HE2F HE2G 12 Week Old Early Uni-ZAP XR LP04 HE2P HE2Q Stage Human, II HPTS HPTT HPTU Human Pituitary, subtracted Uni-ZAP XR LP04 HAUA HAUB HAUC Amniotic Cells- Uni-ZAP XR LP04 TNF induced HAQA HAQB HAQC HAQD Amniotic Cells- Uni-ZAP XR LP04 Primary Culture HWTA HWTB HWTC wilm’s tumor Uni-ZAP XR LP04 HBSD Bone Cancer, re-excision Uni-ZAP XR LP04 HSGB Salivary gland, re-excision Uni-ZAP XR LP04 HSJA HSJB HSJC Smooth muscle-ILb Uni-ZAP XR LP04 induced HSXA HSXB HSXC HSXD Human Substantia Nigra Uni-ZAP XR LP04 HSHA HSHB HSHC Smooth muscle, IL1b Uni-ZAP XR LP04 induced HOUA HOUB HOUC HOUD Adipocytes Uni-ZAP XR LP04 HOUE HPWA HPWB HPWC HPWD Prostate BPH Uni-ZAP XR LP04 HPWE HELA HELB HELC HELD Endothelial Uni-ZAP XR LP04 HELE HELF HELG HELH cells-control HEMA HEMB HEMC HEMD Endothelial-induced Uni-ZAP XR LP04 HEME HEMF HEMG HEMH HBIA HBIB HBIC Human Brain, Striatum Uni-ZAP XR LP04 HHSA HHSB HHSC HHSD Human Hypothalmus, Uni-ZAP XR LP04 HHSE Schizophrenia HNGA HNGB HNGC HNGD neutrophils control Uni-ZAP XR LP04 HNGE HNGF HNGG HNGH HNGI HNGJ HNHA HNHB HNHC HNHD Neutrophils IL-1 Uni-ZAP XR LP04 HNHE HNHF HNHG HNHH and LPS induced HNHI HNHJ HSDB HSDC STRIATUM Uni-ZAP XR LP04 DEPRESSION HHPT Hypothalamus Uni-ZAP XR LP04 HSAT HSAU HSAV HSAW Anergic T-cell Uni-ZAP XR LP04 HSAX HSAY HSAZ HBMS HBMT HBMU HBMV Bone marrow Uni-ZAP XR LP04 HBMW HBMX HOEA HOEB HOEC HOED Osteoblasts Uni-ZAP XR LP04 HOEE HOEF HOEJ HAIA HAIB HAIC HAID Epithelial-TNFa Uni-ZAP XR LP04 HAIE HAIF and INF induced HTGA HTGB HTGC HTGD Apoptotic T-cell Uni-ZAP XR LP04 HMCA HMCB HMCC HMCD Macrophage-oxLDL Uni-ZAP XR LP04 HMCE HMAA HMAB HMAC HMAD Macrophage (GM- Uni-ZAP XR LP04 HMAE HMAF HMAG CSF treated) HPHA Normal Prostate Uni-ZAP XR LP04 HPIA HPIB HPIC LNCAP prostate Uni-ZAP XR LP04 cell line HPJA HPJB HPJC PC3 Prostate cell line Uni-ZAP XR LP04 HOSE HOSF HOSG Human Osteoclastoma, Uni-ZAP XR LP04 re-excision HTGE HTGF Apoptotic T-cell, Uni-ZAP XR LP04 re-excision HMAJ HMAK H Macrophage (GM- Uni-ZAP XR LP04 CSF treated), re-excision HACB HACC HACD Human Adipose Tissue, Uni-ZAP XR LP04 re-excision HFPA H. Frontal Cortex, Uni-ZAP XR LP04 Epileptic HFAA HFAB HFAC HFAD Alzheimers, spongy Uni-ZAP XR LP04 HFAE change HFAM Frontal Lobe, Dementia Uni-ZAP XR LP04 HMIA HMIB HMIC Human Manic Uni-ZAP XR LP04 Depression Tissue HTSA HTSE HTSF HTSG Human Thymus pBS LP05 HTSH HPBA HPBB HPBC Human Pineal Gland pBS LP05 HPBD HPBE HSAA HSAB HSAC HSA 172 Cells pBS LP05 HSBA HSBB HSBC HSBM HSC172 cells pBS LP05 HJAA HJAB HJAC HJAD Jurkat T-cell pBS LP05 G1 phase HJBA HJBB HJBC HJBD Jurkat T-Cell, pBS LP05 S phase HAFA HAFB Aorta endothelial pBS LP05 cells + TNF-a HAWA HAWB HAWC Human White Adipose pBS LP05 HTNA HTNB Human Thyroid pBS LP05 HONA Normal Ovary, pBS LP05 Premenopausal HARA HARB Human Adult Retina pBS LP05 HLJA HLJB Human Lung pCMVSport 1 LP06 HOFM HOFN HOFO H. Ovarian Tumor, pCMVSport 2.0 LP07 II, OV5232 HOGA HOGB HOGC OV 10-3-95 pCMVSport 2.0 LP07 HCGL CD34 + cells, II pCMVSport 2.0 LP07 HDLA Hodgkin’s Lymphoma I pCMVSport 2.0 LP07 HDTA HDTB HDTC HDTD Hodgkin’s Lymphoma II pCMVSport 2.0 LP07 HDTE HKAA HKAB HKAC HKAD Keratinocyte pCMVSport 2.0 LP07 HKAE HKAF HKAG HKAH HCIM CAPFINDER, Crohn’s pCMVSport 2.0 LP07 Disease, lib 2 HKAL Keratinocyte, lib 2 pCMVSport 2.0 LP07 HKAT Keratinocyte, lib 3 pCMVSport 2.0 LP07 HNDA Nasal polyps pCMVSport 2.0 LP07 HDRA H. Primary Dendritic pCMVSport 2.0 LP07 Cells, lib 3 HOHA HOHB HOHC Human Osteoblasts II pCMVSport 2.0 LP07 HLDA HLDB HLDC Liver, Hepatoma pCMVSport 3.0 LP08 HLDN HLDO HLDP Human Liver, normal pCMVSport 3.0 LP08 HMTA pBMC stimulated w/ pCMVSport 3.0 LP08 poly I/C HNTA NTERA2, control pCMVSport 3.0 LP08 HDPA HDPB HDPC HDPD Primary Dendritic pCMVSport 3.0 LP08 HDPF HDPG HDPH HDPI Cells, lib 1 HDPJ HDPK HDPM HDPN HDPO HDPP Primary Dendritic pCMVSport 3.0 LP08 cells, frac 2 HMUA HMUB HMUC Myoloid Progenitor pCMVSport 3.0 LP08 Cell Line HHEA HHEB HHEC HHED T Cell helper I pCMVSport 3.0 LP08 HHEM HHEN HHEO HHEP T cell helper II pCMVSport 3.0 LP08 HEQA HEQB HEQC Human endometrial pCMVSport 3.0 LP08 stromal cells HJMA HJMB Human endometrial pCMVSport 3.0 LP08 stromal cells- treated with progesterone HSWA HSWB HSWC Human endometrial pCMVSport 3.0 LP08 stromal cells- treated with estradiol HSYA HSYB HSYC Human Thymus pCMVSport 3.0 LP08 Stromal Cells HLWA HLWB HLWC Human Placenta pCMVSport 3.0 LP08 HRAA HRAB HRAC Rejected Kidney, lib 4 pCMVSport 3.0 LP08 HMTM PCR, pBMC I/C treated PCRII LP09 HMJA H. Meniingima, M6 pSport 1 LP10 HMKA HMKB HMKC HMKD H. Meningima, M1 pSport 1 LP10 HMKE HUSG HUSI Human umbilical vein pSport 1 LP10 endothelial cells, IL-4 induced HUSX HUSY Human Umbilical Vein pSport 1 LP10 Endothelial Cells, uninduced HOFA Ovarian Tumor I, OV5232 pSport I LP10 HCFA HCFB HCFC HCFD T-Cell PHA 16 hrs pSport 1 LP10 HCFL HCFM HCFN HCFO T-Cell PHA 24 hrs pSport 1 LP10 HADA HADC HADD HADE Human Adipose pSport 1 LP10 HADF HADG HOVA HOVB HOVC Human Ovary pSport 1 LP10 HTWB HTWC HTWD HTWE Resting T-Cell pSport 1 LP10 HTWF Library, II HMMA Spleen metastic melanoma pSport 1 LP10 HLYA HLYB HLYC HLYD Spleen, Chronic pSport 1 LP10 HLYE lymphocytic leukemia HCGA CD34 + cell, I pSport 1 LP10 HEOM HEON Human Eosinophils pSport 1 LP10 HTDA Human Tonsil, Lib 3 pSport 1 LP10 HSPA Salivary Gland, Lib 2 pSport 1 LP10 HCHA HCHB HCHC Breast Cancer cell pSport 1 LP10 line, MDA 36 HCHM HCHN Breast Cancer Cell pSport 1 LP10 line, angiogenic HCIA Crohn’s Disease pSport 1 LP10 HDAA HDAB HDAC HEL cell line pSport 1 LP10 HABA Human Astrocyte pSport 1 LP10 HUFA HUFB HUFC Ulcerative Colitis pSport 1 LP10 HNTM NTERA2 + retinoic pSport 1 LP10 acid, 14 days HDQA Primary Dendritic cells, pSport 1 LP10 CapFinder2, frac 1 HDQM Primary Dendritic Cells, pSport 1 LP10 CapFinder, frac 2 HLDX Human Liver, normal, pSport 1 LP10 HULA HULB HULC Human Dermal pSport 1 LP10 Endothelial Cells, untreated HUMA Human Dermal pSport 1 LP10 Endothelial cells, treated HCJA Human Stromal pSport 1 LP10 Endometrial fibroblasts, untreated HCJM Human Stromal pSport 1 LP10 endometrial fibroblasts, treated w/ estradiol HEDA Human Stromal pSport 1 LP10 endometrial fibroblasts, treated with progesterone HFNA Human ovary tumor pSport 1 LP10 cell OV350721 HKGA HKGB HKGC HKGD Merkel Cells pSport 1 LP10 HISA HISB HISC Pancreas Islet pSport 1 LP10 Cell Tumor HLSA Skin, burned pSport 1 LP10 HBZA Prostate, BPH, Lib 2 pSport 1 LP10 HBZS Prostate BPH, Lib pSport 1 LP10 2, subtracted HFIA HFIB HFIC Synovial Fibroblasts pSport 1 LP10 (control) HFIH HFII HFIJ Synovial hypoxia pSport 1 LP10 HFIT HFIU HFIV Synovial IL-1/TNF pSport 1 LP10 stimulated HGCA Messangial cell, frac 1 pSport 1 LP10 HMVA HMVB HMVC Bone Marrow Stromal pSport 1 LP10 Cell, untreated HFIX HFIY HFIZ Synovial Fibroblasts pSport 1 LP10 (II1/TNF), subt HFOX HFOY HFOZ Synovial hypoxia-RSF pSport 1 LP10 subtracted HMQA HMQB HMQC HMQD Human Activated Uni-ZAP XR LP11 Monocytes HLIA HLIB HLIC Human Liver pCMVSport 1 LP012 HHBA HHBB HHBC HHBD Human Heart pCMVSport 1 LP012 HHBE HBBA HBBB Human Brain pCMVSport 1 LP012 HLJA HLJB HLJC HLJD Human Lung pCMVSport 1 LP012 HLJE HOGA HOGB HOGC Ovarian Tumor pCMVSport 2.0 LP012 HTJM Human Tonsils, Lib 2 pCMVSport 2.0 LP012 HAMF HAMG KMH2 pCMVSport 3.0 LP012 HAJA HAJB HAJC L428 pCMVSport 3.0 LP012 HWBA HWBB HWBC HWBD Dendritic cells, pooled pCMVSport 3.0 LP012 HWBE HWAA HWAB HWAC HWAD Human Bone Marrow, pCMVSport 3.0 LP012 HWAE treated HYAA HYAB HYAC B Cell lymphoma pCMVSport 3.0 LP012 HWHG HWHH HWHI Healing groin wound, pCMVSport 3.0 LP012 6.5 hours post incision HWHP HWHQ HWHR Healing groin wound; pCMVSport 3.0 LP012 7.5 hours post incision HARM Healing groin wound- pCMVSport 3.0 LP012 zero hr post- incision (control) HBIM Olfactory epithelium; pCMVSport 3.0 LP012 nasalcavity HWDA Healing Abdomen wound; pCMVSport 3.0 LP012 70&90 min post incision HWEA Healing Abdomen pCMVSport 3.0 LP012 Wound; 15 days post incision HWJA Healing Abdomen pCMVSport 3.0 LP012 Wound; 21&29 days HNAL Human Tongue, frac 2 pSport1 LP012 HMJA H. Meniingima, M6 pSport1 LP012 HMKA HMKB HMKC HMKD H. Meningima, M1 pSport1 LP012 HMKE HOFA Ovarian Tumor I, pSport1 LP012 OV5232 HCFA HCFB HCFC HCFD T-Cell PHA 16 hrs pSport1 LP012 HCFL HCFM HCFN HCFO T-Cell PHA 24 hrs pSport1 LP012 HMMA HMMB HMMC Spleen metastic pSport1 LP012 melanoma HTDA Human Tonsil, Lib 3 pSport1 LP012 HDBA Human Fetal Thymus pSport1 LP012 HDUA Pericardium pSport1 LP012 HBZA Prostate, BPH, Lib 2 pSport1 LP012 HWCA Larynx tumor pSport1 LP012 HWKA Normal lung pSport1 LP012 HSMB Bone marrow pSport1 LP012 stroma, treated HBHM Normal trachea pSport1 LP012 HLFC Human Larynx pSport1 LP012 HLRB Siebben Polyposis pSport1 LP012 HNIA Mammary Gland pSport1 LP012 HNJB Palate carcinoma pSport1 LP012 HNKA Palate normal pSport1 LP012 HMZA Pharynx carcinoma pSport1 LP012 HABG Cheek Carcinoma pSport1 LP012 HMZM Pharynx Carcinoma pSport1 LP012 HDRM Larynx Carcinoma pSport1 LP012 HVAA Pancreas normal pSport1 LP012 PCA4 No HICA Tongue carcinoma pSport1 LP012 HUKA HUKB HUKC HUKD Human Uterine Cancer Lambda ZAP II LP013 HUKE HFFA Human Fetal Brain, Lambda ZAP II LP013 random primed HTUA Activated T-cell labeled Lambda ZAP II LP013 with 4-thioluri HBQA Early Stage Human Brain, Lambda ZAP II LP013 random primed HMEB Human microvascular Lambda ZAP II LP013 Endothelial cells, fract. B HUSH Human Umbilical Vein Lambda ZAP II LP013 Endothelial cells, fract. A, re-excision HLQC HLQD Hepatocellular tumor, Lambda ZAP II LP013 re-excision HTWJ HTWK HTWL Resting T-cell, Lambda ZAP II LP013 re-excision HF6S Human Whole 6 week pBluescript LP013 Old Embryo (II), subt HHPS Human Hippocampus, pBluescript LP013 subtracted HL1S LNCAP, differential pBluescript LP013 expression HLHS HLHT Early Stage Human pBluescript LP013 Lung, Subtracted HSUS Supt cells, cyclohexamide pBluescript LP013 treated, subtracted HSUT Supt cells, cyclohexamide pBluescript LP013 treated, differentially expressed HSDS H. Striatum Depression, pBluescript LP013 subtracted HPTZ Human Pituitary, pBluescript LP013 Subtracted VII HSDX H. Striatum Depression, pBluescript LP013 subt II HSDZ H. Striatum Depression, pBluescript LP013 subt HPBA HPBB HPBC HPBD Human Pineal Gland pBluescript SK- LP013 HPBE HRTA Colorectal Tumor pBluescript SK- LP013 HSBA HSBB HSBC HSBM HSC172 cells pBluescript SK- LP013 HJAA HJAB HJAC HJAD Jurkat T-cell G1 phase pBluescript SK- LP013 HJBA HJBB HJBC HJBD Jurkat T-cell, S1 phase pBluescript SK- LP013 HTNA HTNB Human Thyroid pBluescript SK- LP013 HAHA HAHB Human Adult Heart Uni-ZAP XR LP013 HE6A Whole 6 week Uni-ZAP XR LP013 Old Embryo HFCA HFCB HFCC HFCD Human Fetal Brain Uni-ZAP XR LP013 HFCE HFKC HFKD HFKE HFKF Human Fetal Kidney Uni-ZAP XR LP013 HFKG HGBA HGBD HGBE HGBF Human Gall Bladder Uni-ZAP XR LP013 HGBG HPRA HPRB HPRC HPRD Human Prostate Uni-ZAP XR LP013 HTEA HTEB HTEC HTED Human Testes Uni-ZAP XR LP013 HTEE HTTA HTTB HTTC HTTD Human Testes Tumor Uni-ZAP XR LP013 HTEE HYBA HYBB Human Fetal Bone Uni-ZAP XR LP013 HFLA Human Fetal Liver Uni-ZAP XR LP013 HHFB HHFC HHFD HHFE Human Fetal Heart Uni-ZAP XR LP013 HHFF HUVB HUVC HUVD HUVE Human Umbilical Vein, Uni-ZAP XR LP013 End remake HTHB HTHC HTHD Human Thymus Uni-ZAP XR LP013 HSTA HSTB HSTC HSTD Human Skin Tumor Uni-ZAP XR LP013 HTAA HTAB HTAC HTAD Human Activated T-cells Uni-ZAP XR LP013 HTAE HFEA HFEB HFEC Human Fetal Uni-ZAP XR LP013 Epithelium (skin) HJPA HJPB HJPC HJPD Human Jurkat Membrane Uni-ZAP XR LP013 Bound Polysomes HESA Human Epithelioid Uni-ZAP XR LP013 Sarcoma HALS Human Adult Liver, Uni-ZAP XR LP013 Subtracted HFTA HFTB HFTC HFTD Human Fetal Uni-ZAP XR LP013 Dura Mater HCAA HCAB HCAC Cem cells, cyclo- Uni-ZAP XR LP013 hexamide treated HRGA HRGB HRGC HRGD Raji Cells, cyclo- Uni-ZAP XR LP013 hexamide treated HE9A HE9B HE9C HE9D Nine Week Old Early Uni-ZAP XR LP013 HE9E Stage Human HSFA Human Fibrosarcoma Uni-ZAP XR LP013 HATA HATB HATC HATD Human Adrenal Gland Uni-ZAP XR LP013 HATE Tumor HTRA Human Trachea Tumor Uni-ZAP XR LP013 HE2A HE2D HE2E HE2H 12 Week Old Early Uni-ZAP XR LP013 HE2I Stage Human HE2B HE2C HE2F HE2G 12 Week Old Early Uni-ZAP XR LP013 HE2P Stage Human, II HENA HNEB HNEC HNED Human Neutrophil Uni-ZAP XR LP013 HNEE HBGA Human Primary Uni-ZAP XR LP013 Breast Cancer HPTS HPTT HPTU Human Pituitary, Uni-ZAP XR LP013 subtracted HMQA HMQB HMQC HMQD Human Activated Uni-ZAP XR LP013 Monocytes HOAA HOAB HOAC Human Osteosarcoma Uni-ZAP XR LP013 HTOA HTOD HTOE HTOF human tonsils Uni-ZAP XR LP013 HTOG HMGB Human OB MG63 Uni-ZAP XR LP013 control fraction I HOPB Human OB HOS Uni-ZAP XR LP013 control fraction I HOQB Human OB HOS Uni-ZAP XR LP013 treated (1 nM E2) fraction I HAUA HAUB HAUC Amniotic Cells- Uni-ZAP XR LP013 TNF induced HAQA HAQB HAQC HAQD Amniotic Cells- Uni-ZAP XR LP013 Primary Culture HROA HROC HUMAN STOMACH Uni-ZAP XR LP013 HBJA HBJB HBJC HBJD HUMAN B CELL Uni-ZAP XR LP013 HBJE LYMPHOMA HODA HODB HODC HODD human ovarian cancer Uni-ZAP XR LP013 HCPA Corpus Callosum Uni-ZAP XR LP013 HSOA stomach cancer (human) Uni-ZAP XR LP013 HERA SKIN Uni-ZAP XR LP013 HMDA Brain-medulloblastoma Uni-ZAP XR LP013 HGLA HGLB HGLD Glioblastoma Uni-ZAP XR LP013 HWTA HWTB HWTC wilm’s tumor Uni-ZAP XR LP013 HEAA H. Atrophic Endometrium Uni-ZAP XR LP013 HAPN HAPO HAPP HAPQ Human Adult Uni-ZAP XR LP013 HAPR Pulmonary; re-excision HLTG HLTH Human T-cell Uni-ZAP XR LP013 lymphoma; re-excision HAHC HAHD HAHE Human Adult Heart; Uni-ZAP XR LP013 re-excision HAGA HAGB HAGC HAGD Human Amygdala Uni-ZAP XR LP013 HAGE HSJA HSJB HSJC Smooth muscle-ILb Uni-ZAP XR LP013 induced HSHA HSHB HSHC Smooth muscle, Uni-ZAP XR LP013 IL1b induced HPWA HPWB HPWC HPWD Prostate BPH Uni-ZAP XR LP013 HPWE HPIA HPIB HPIC LNCAP prostate Uni-ZAP XR LP013 cell line HPJA HPJB HPJC PC3 Prostate cell line Uni-ZAP XR LP013 HBTA Bone Marrow Stroma, Uni-ZAP XR LP013 TNF&LPS ind HMCF HMCG HMCH HMCI Macrophage-oxLDL; Uni-ZAP XR LP013 HMCJ re-excision HAGG HAGH HAGI Human Amygdala; Uni-ZAP XR LP013 re-excision HACA H. Adipose Tissue Uni-ZAP XR LP013 HKFB K562 + PMA (36 hrs), ZAP Express LP013 re-excision HCWT HCWU HCWV CD34 positive cells ZAP Express LP013 (cord blood), re-ex HBWA Whole brain ZAP Express LP013 HBXA HBXB HBXC HBXD Human Whole Brain #2- ZAP Express LP013 Oligo dT > 1.5Kb HAVM Temporal cortex- pT-Adv LP014 Alzheizmer HAVT Hippocampus, Alzheimer pT-Adv LP014 Subtracted HHAS CHME Cell Line Uni-ZAP XR LP014 HAJR Larynx normal pSport 1 LP014 HWLE HWLF HWLG HWLH Colon Normal pSport 1 LP014 HCRM HCRN HCRO Colon Carcinoma pSport 1 LP014 HWLI HWLJ HWLK Colon Normal pSport 1 LP014 HWLQ HWLR HWLS HWLT Colon Tumor pSport 1 LP014 HBFM Gastrocnemius Muscle pSport 1 LP014 HBOD HBOE Quadriceps Muscle pSport 1 LP014 HBKD HBKE Soleus Muscle pSport 1 LP014 HCCM Pancreatic Langerhans pSport 1 LP014 HWGA Larynx carcinoma pSport 1 LP014 HWGM HWGN Larynx carcinoma pSport 1 LP014 HWLA HWLB HWLC Normal colon pSport 1 LP014 HWLM HWLN Colon Tumor pSport 1 LP014 HVAM HVAN HVAO Pancreas Tumor pSport 1 LP014 HWGQ Larynx carcinoma pSport 1 LP014 HAQM HAQN Salivary Gland pSport 1 LP014 HASM Stomach; normal pSport 1 LP014 HBCM Uterus; normal pSport 1 LP014 HCDM Testis; normal pSport 1 LP014 HDJM Brain; normal pSport 1 LP014 HEFM Adrenal Gland, normal pSport 1 LP014 HBAA Rectum normal pSport 1 LP014 HFDM Rectum tumour pSport 1 LP014 HGAM Colon, normal pSport 1 LP014 HHMM Colon, tumour pSport 1 LP014 HCLB HCLC Human Lung Cancer Lambda Zap II LP015 HRLA L1 Cell line ZAP Express LP015 HHAM Hypothalamus, pCMV Sport 3.0 LP015 Alzheimer’s HKBA Ku 812F Basophils Line pSport 1 LP015 HS2S Saos2, Dexamethosome pSport 1 LP016 Treated HA5A Lung Carcinoma A549 pSport 1 LP016 TNFalpha activated HTFM TF-1 Cell Line GM- pSport 1 LP016 CSF Treated HYAS Thyroid Tumour pSport 1 LP016 HUTS Larynx Normal pSport 1 LP016 HXOA Larynx Tumor pSport 1 LP016 HEAH Ea.hy.926 cell line pSport 1 LP016 HINA Adenocarcinoma Human pSport 1 LP016 HRMA Lung Mesothelium pSport 1 LP016 HLCL Human Pre-Differentiated Uni-Zap XR LP017 Adipocytes HS2A Saos2 Cells pSport 1 LP020 HS2I Saos2 Cells; Vitamin pSport 1 LP020 D3 Treated HUCM CHME Cell Line, pSport 1 LP020 untreated HEPN Aryepiglottis Normal pSport 1 LP020 HPSN Sinus Piniformis Tumour pSport 1 LP020 HNSA Stomach Normal pSport 1 LP020 HNSM Stomach Tumour pSport 1 LP020 HNLA Liver Normal Met5No pSport 1 LP020 HUTA Liver Tumour Met 5 Tu pSport 1 LP020 HOCN Colon Normal pSport 1 LP020 HOCT Colon Tumor pSport 1 LP020 HTNT Tongue Tumour pSport 1 LP020 HLXN Larynx Normal pSport 1 LP020 HLXT Larynx Tumour pSport 1 LP020 HTYN Thymus pSport 1 LP020 HPLN Placenta pSport 1 LP020 HTNG Tongue Normal pSport 1 LP020 HZAA Thyroid Normal (SDCA2 pSport 1 LP020 No) HWES Thyroid Thyroiditis pSport 1 LP020 HFHD Ficolled Human Stromal pTrip1Ex2 LP021 Cells, 5Fu treated HFHM, HFHN Ficolled Human Stromal pTrip1Ex2 LP021 Cells, Untreated HPCI Hep G2 Cells, lambda lambda Zap-CMV LP021 library XR HBCA, HBCB, HBCC H. Lymph node breast Uni-ZAP XR LP021 Cancer HCOK Chondrocytes pSPORT1 LP022 HDCA, HDCB, HDCC Dendritic Cells From pSPORT1 LP022 CD34 Cells HDMA, HDMB CD40 activated monocyte pSPORT1 LP022 dendritic cells HDDM, HDDN, HDDO LPS activated derived pSPORT1 LP022 dendritic cells HPCR Hep G2 Cells, PCR lambda Zap-CMV LP022 library XR HAAA, HAAB, HAAC Lung, Cancer pSPORT1 LP022 (4005313A3): Invasive Poorly Differentiated Lung Adenocarcinoma HIPA, HIPB, HIPC Lung, Cancer pSPORTl LP022 (4005163 B7): Invasive, Poorly Diff. Adeno- carcinoma, Metastatic HOOH, HOOI Ovary, Cancer: (4004562 pSPORT1 LP022 B6) Papillary Serous Cystic Neoplasm, Low Malignant Pot HIDA Lung, Normal: pSPORT1 LP022 (4005313 B1) HUJA, HUJB, HUJC, B-Cells pCMVSport 3.0 LP022 HUJD, HUJE HNOA, HNOB, HNOC, Ovary, Normal: pSPORT1 LP022 HNOD (9805C040R) HNLM Lung, Normal: pSPORT1 LP022 (4005313 B1) HSCL Stromal Cells pSPORT1 LP022 HAAX Lung, Cancer: (4005313 pSPORT1 LP022 A3) Invasive Poorly- differentiated Metastatic lung adenocarcinoma HUUA, HUUB, HUUC, HUUD B-cells (unstimulated) pTrip1Ex2 LP022 HWWA, HWWB, HWWC, B-cells (stimulated) pSPORT1 LP022 HWWD, HWWE, HWWF, HWWG HCCC Colon, Cancer: pCMVSport 3.0 LP023 (9808C064R) HPDO HPDP HPDQ HPDR Ovary, Cancer (9809C- pSport 1 LP023 HPD 332): Poorly differ- entiated adenocarcinoma HPCO HPCP HPCQ HPCT Ovary, Cancer (15395- pSport 1 LP023 A1F): Grade II Papillary Carcinoma HOCM HOCO HOCP HOCQ Ovary, Cancer: (15799- pSport 1 LP023 A1F) Poorly differentiated carcinoma HCBM HCBN HCBO Breast, Cancer: pSport 1 LP023 (4004943 A5) HNBT HNBU HNBV Breast, Normal: pSport 1 LP023 (4005522B2) HBCP HBCQ Breast, Cancer: pSport 1 LP023 (4005522 A2) HBCJ Breast, Cancer: pSport 1 LP023 (9806C012R) HSAM HSAN Stromal cells 3.88 pSport 1 LP023 HVCA HVCB HVCC HVCD Ovary, Cancer: pSport 1 LP023 (4004332 A2) HSCK HSEN HSEO Stromal cells (HBM3.18) pSport 1 LP023 HSCP HSCQ stromal cell clone 2.5 pSport 1 LP023 HUXA Breast Cancer: pSport 1 LP023 (4005385 A2) HCOM HCON HCOO HCOP Ovary, Cancer (4004- pSport 1 LP023 HCOQ 650 A3): Well-Differ- entiated Micropapillary Serous Carcinoma HBNM Breast, Cancer: pSport 1 LP023 (9802C020E) HVVA HVVB HVVC HVVD Human Bone Marrow, pSport 1 LP023 HVVE treated

[0952] Two nonlimiting examples are provided below for isolating a particular clone from the deposited sample of plasmid cDNAs cited for that clone in Table 7. First, a plasmid is directly isolated by screening the clones using a polynucleotide probe corresponding to the nucleotide sequence of SEQ ID NO: X.

[0953] Particularly, a specific polynucleotide with 30-40 nucleotides is synthesized using an Applied Biosystems DNA synthesizer according to the sequence reported. The oligonucleotide is labeled, for instance, with ³²P-γ-ATP using T4 polynucleotide kinase and purified according to routine methods. (E.g., Maniatis et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, Cold Spring, N.Y. (1982).) The plasmid mixture is transformed into a suitable host, as indicated above (such as XL-1 Blue (Stratagene)) using techniques known to those of skill in the art, such as those provided by the vector supplier or in related publications or patents cited above. The transformants are plated on 1.5% agar plates (containing the appropriate selection agent, e.g., ampicillin) to a density of about 150 transformants (colonies) per plate. These plates are screened using Nylon membranes according to routine methods for bacterial colony screening (e.g., Sambrook et al., Molecular Cloning: A Laboratory Manual, 2nd Edit., (1989), Cold Spring Harbor Laboratory Press, pages 1.93 to 1.104), or other techniques known to those of skill in the art.

[0954] Alternatively, two primers of 17-20 nucleotides derived from both ends of the nucleotide sequence of SEQ ID NO: X are synthesized and used to amplify the desired cDNA using the deposited cDNA plasmid as a template. The polymerase chain reaction is carried out under routine conditions, for instance, in 25 μl of reaction mixture with 0.5 μg of the above cDNA template. A convenient reaction mixture is 1.5-5 mM MgCl₂, 0.01% (w/v) gelatin, 20 μM each of dATP, dCTP, dGTP, dTTP, 25 pmol of each primer and 0.25 Unit of Taq polymerase. Thirty five cycles of PCR (denaturation at 94° C. for 1 min; annealing at 55° C. for 1 min; elongation at 72° C. for 1 min) are performed with a Perkin-Elmer Cetus automated thermal cycler. The amplified product is analyzed by agarose gel electrophoresis and the DNA band with expected molecular weight is excised and purified. The PCR product is verified to be the selected sequence by subcloning and sequencing the DNA product.

[0955] Several methods are available for the identification of the 5′ or 3′ non-coding portions of a gene which may not be present in the deposited clone. These methods include but are not limited to, filter probing, clone enrichment using specific probes, and protocols similar or identical to 5′ and 3′ “RACE” protocols which are well known in the art. For instance, a method similar to 5′ RACE is available for generating the missing 5′ end of a desired full-length transcript. (Fromont-Racine et al., Nucleic Acids Res. 21(7):1683-1684 (1993).)

[0956] Briefly, a specific RNA oligonucleotide is ligated to the 5′ ends of a population of RNA presumably containing full-length gene RNA transcripts. A primer specific to the ligated RNA oligonucleotide and a primer specific to a known sequence of the gene of interest is used to PCR amplify the 5′ portion of the desired full-length gene. This amplified product may then be sequenced and used to generate the full length gene.

[0957] This above method starts with total RNA isolated from the desired source, although poly-A+ RNA can be used. The RNA preparation can then be treated with phosphatase if necessary to eliminate 5′ phosphate groups on degraded or damaged RNA which may interfere with the later RNA ligase step. The phosphatase should then be inactivated and the RNA treated with tobacco acid pyrophosphatase in order to remove the cap structure present at the 5′ ends of messenger RNAs. This reaction leaves a 5′ phosphate group at the 5′ end of the cap cleaved RNA which can then be ligated to an RNA oligonucleotide using T4 RNA ligase.

[0958] This modified RNA preparation is used as a template for first strand cDNA synthesis using a gene specific oligonucleotide. The first strand synthesis reaction is used as a template for PCR amplification of the desired 5′ end using a primer specific to the ligated RNA oligonucleotide and a primer specific to the known sequence of the gene of interest. The resultant product is then sequenced and analyzed to confirm that the 5′ end sequence belongs to the desired gene.

Example 2 Isolation of Genomic Clones Corresponding to a Polynucleotide

[0959] A human genomic P1 library (Genomic Systems, Inc.) is screened by PCR using primers selected for the sequence corresponding to SEQ ID NO: X according to the method described in Example 1. (See also, Sambrook et al., Molecular Cloning: A Laboratory Manual, 2nd Edn., (1989), Cold Spring Harbor Laboratory Press).

Example 3 Tissue Specific Expression Analysis

[0960] The Human Genome Sciences, Inc. (HGS) database is derived from sequencing tissue and/or disease specific cDNA libraries. Libraries generated from a particular tissue are selected and the specific tissue expression pattern of EST groups or assembled contigs within these libraries is determined by comparison of the expression patterns of those groups or contigs within the entire database. ESTs and assembled contigs which show tissue specific expression are selected.

[0961] The original clone from which the specific EST sequence was generated, or in the case of an assembled contig, the clone from which the 5′ most EST sequence was generated, is obtained from the catalogued library of clones and the insert amplified by PCR using methods known in the art. The PCR product is denatured and then transferred in 96 or 384 well format to a nylon membrane (Schleicher and Scheull) generating an array filter of tissue specific clones. Housekeeping genes, maize genes, and known tissue specific genes are included on the filters. These targets can be used in signal normalization and to validate assay sensitivity. Additional targets are included to monitor probe length and specificity of hybridization.

[0962] Radioactively labeled hybridization probes are generated by first strand cDNA synthesis per the manufacturer's instructions (Life Technologies) from mRNA/RNA samples prepared from the specific tissue being analyzed (e.g., reproductive system, cancers of the reproductive system, or, more specifically, prostate, prostate cancer, ovarian, ovarian cancer, etc.). The hybridization probes are purified by gel exclusion chromatography, quantitated, and hybridized with the array filters in hybridization bottles at 65° C. overnight. The filters are washed under stringent conditions and signals are captured using a Fuji phosphorimager.

[0963] Data is extracted using AIS software and following background subtraction, signal normalization is performed. This includes a normalization of filter-wide expression levels between different experimental runs. Genes that are differentially expressed in the tissue of interest are identified.

Example 4 Chromosomal Mapping of the Polynucleotides

[0964] An oligonucleotide primer set is designed according to the sequence at the 5′ end of SEQ ID NO: X. This primer preferably spans about 100 nucleotides. This primer set is then used in a polymerase chain reaction under the following set of conditions: 30 seconds, 95° C.; 1 minute, 56° C.; 1 minute, 70° C. This cycle is repeated 32 times followed by one 5 minute cycle at 70° C. Human, mouse, and hamster DNA is used as template in addition to a somatic cell hybrid panel containing individual chromosomes or chromosome fragments (Bios, Inc). The reactions are analyzed on either 8% polyacrylamide gels or 3.5% agarose gels. Chromosome mapping is determined by the presence of an approximately 100 bp PCR fragment in the particular somatic cell hybrid.

Example 5 Bacterial Expression of a Polypeptide

[0965] A polynucleotide encoding a polypeptide of the present invention is amplified using PCR oligonucleotide primers corresponding to the 5′ and 3′ ends of the DNA sequence, as outlined in Example 1, to synthesize insertion fragments. The primers used to amplify the cDNA insert should preferably contain restriction sites, such as BamHI and XbaI, at the 5′ end of the primers in order to clone the amplified product into the expression vector. For example, BamHI and XbaI correspond to the restriction enzyme sites on the bacterial expression vector pQE-9. (Qiagen, Inc., Chatsworth, Calif.). This plasmid vector encodes antibiotic resistance (Amp^(r)), a bacterial origin of replication (ori), an IPTG-regulatable promoter/operator (P/O), a ribosome binding site (RBS), a 6-histidine tag (6-His), and restriction enzyme cloning sites.

[0966] The pQE-9 vector is digested with BamHI and XbaI and the amplified fragment is ligated into the pQE-9 vector maintaining the reading frame initiated at the bacterial RBS. The ligation mixture is then used to transform the E. coli strain M15/rep4 (Qiagen, Inc.) which contains multiple copies of the plasmid pREP4, which expresses the lacI repressor and also confers kanamycin resistance (Kanr). Transformants are identified by their ability to grow on LB plates and ampicillin/kanamycin resistant colonies are selected. Plasmid DNA is isolated and confirmed by restriction analysis.

[0967] Clones containing the desired constructs are grown overnight (O/N) in liquid culture in LB media supplemented with both Amp (100 ug/ml) and Kan (25 ug/ml). The O/N culture is used to inoculate a large culture at a ratio of 1:100 to 1:250. The cells are grown to an optical density 600 (O.D.⁶⁰⁰) of between 0.4 and 0.6. IPTG (Isopropyl-B-D-thiogalacto pyranoside) is then added to a final concentration of 1 mM. IPTG induces by inactivating the lacI repressor, clearing the P/O leading to increased gene expression.

[0968] Cells are grown for an extra 3 to 4 hours. Cells are then harvested by centrifugation (20 mins at 6000×g). The cell pellet is solubilized in the chaotropic agent 6 Molar Guanidine HCl by stirring for 3-4 hours at 4° C. The cell debris is removed by centrifugation, and the supernatant containing the polypeptide is loaded onto a nickel-nitrilo-tri-acetic acid (“Ni-NTA”) affinity resin column (available from QIAGEN, Inc., supra). Proteins with a 6×His tag bind to the Ni-NTA resin with high affinity and can be purified in a simple one-step procedure (for details see: The QIAexpressionist (1995) QIAGEN, Inc., supra).

[0969] Briefly, the supernatant is loaded onto the column in 6 M guanidine-HCl, pH 8. The column is first washed with 10 volumes of 6 M guanidine-HCl, pH 8, then washed with 10 volumes of 6 M guanidine-HCl pH 6, and finally the polypeptide is eluted with 6 M guanidine-HCl, pH 5.

[0970] The purified protein is then renatured by dialyzing it against phosphate-buffered saline (PBS) or 50 mM Na-acetate, pH 6 buffer plus 200 mM NaCl. Alternatively, the protein can be successfully refolded while immobilized on the Ni-NTA column. The recommended conditions are as follows: renature using a linear 6M-1M urea gradient in 500 mM NaCl, 20% glycerol, 20 mM Tris/HCl pH 7.4, containing protease inhibitors. The renaturation should be performed over a period of 1.5 hours or more. After renaturation the proteins are eluted by the addition of 250 mM immidazole. Immidazole is removed by a final dialyzing step against PBS or 50 mM sodium acetate pH 6 buffer plus 200 mM NaCl. The purified protein is stored at 4° C. or frozen at -80° C.

[0971] In addition to the above expression vector, the present invention further includes an expression vector, called pHE4a (ATCC Accession Number 209645, deposited on Feb. 25, 1998) which contains phage operator and promoter elements operatively linked to a polynucleotide of the present invention. This vector contains: 1) a neomycinphosphotransferase gene as a selection marker, 2) an E. coli origin of replication, 3) a T5 phage promoter sequence, 4) two lac operator sequences, 5) a Shine-Delgamo sequence, and 6) the lactose operon repressor gene (lacIq). The origin of replication (oriC) is derived from pUC19 (LTI, Gaithersburg, Md.). The promoter and operator sequences are made synthetically.

[0972] DNA can be inserted into the pHE4a by restricting the vector with NdeI and XbaI, BamHI, XhoI, or Asp718, running the restricted product on a gel, and isolating the larger fragment (the stuffer fragment should be about 310 base pairs). The DNA insert is generated according to the PCR protocol described in Example 1, using PCR primers having restriction sites for NdeI (5′ primer) and XbaI, BamHI, XhoI, or Asp718 (3′ primer). The PCR insert is gel purified and restricted with compatible enzymes. The insert and vector are ligated according to standard protocols.

[0973] The engineered vector could easily be substituted in the above protocol to express protein in a bacterial system.

Example 6 Purification of a Polypeptide from an Inclusion Body

[0974] The following alternative method can be used to purify a polypeptide expressed in E coli when it is present in the form of inclusion bodies. Unless otherwise specified, all of the following steps are conducted at 4-10° C.

[0975] Upon completion of the production phase of the E. Coli fermentation, the cell culture is cooled to 4-10° C. and the cells harvested by continuous centrifugation at 15,000 rpm (Heraeus Sepatech). On the basis of the expected yield of protein per unit weight of cell paste and the amount of purified protein required, an appropriate amount of cell paste, by weight, is suspended in a buffer solution containing 100 mM Tris, 50 mM EDTA, pH 7.4. The cells are dispersed to a homogeneous suspension using a high shear mixer.

[0976] The cells are then lysed by passing the solution through a microfluidizer (Microfuidics, Corp. or APV Gaulin, Inc.) twice at 4000-6000 psi. The homogenate is then mixed with NaCl solution to a final concentration of 0.5 M NaCl, followed by centrifugation at 7000×g for 15 min. The resultant pellet is washed again using 0.5M NaCl, 100 mM Tris, 50 mM EDTA, pH 7.4.

[0977] The resulting washed inclusion bodies are solubilized with 1.5 M guanidine hydrochloride (GuHCl) for 2-4 hours. After 7000×g centrifugation for 15 min., the pellet is discarded and the polypeptide containing supernatant is incubated at 4° C. overnight to allow further GuHCl extraction.

[0978] Following high speed centrifugation (30,000×g) to remove insoluble particles, the GuHCl solubilized protein is refolded by quickly mixing the GuHCl extract with 20 volumes of buffer containing 50 mM sodium, pH 4.5, 150 mM NaCl, 2 mM EDTA by vigorous stirring. The refolded diluted protein solution is kept at 4° C. without mixing for 12 hours prior to further purification steps.

[0979] To clarify the refolded polypeptide solution, a previously prepared tangential filtration unit equipped with 0.16 μm membrane filter with appropriate surface area (e.g., Filtron), equilibrated with 40 mM sodium acetate, pH 6.0 is employed. The filtered sample is loaded onto a cation exchange resin (e.g., Poros HS-50, Perseptive Biosystems). The column is washed with 40 mM sodium acetate, pH 6.0 and eluted with 250 mM, 500 mM, 1000 mM, and 1500 mM NaCl in the same buffer, in a stepwise manner. The absorbance at 280 nm of the effluent is continuously monitored. Fractions are collected and further analyzed by SDS-PAGE.

[0980] Fractions containing the polypeptide are then pooled and mixed with 4 volumes of water. The diluted sample is then loaded onto a previously prepared set of tandem columns of strong anion (Poros HQ-50, Perseptive Biosystems) and weak anion (Poros CM-20, Perseptive Biosystems) exchange resins. The columns are equilibrated with 40 mM sodium acetate, pH 6.0. Both columns are washed with 40 mM sodium acetate, pH 6.0, 200 mM NaCl. The CM-20 column is then eluted using a 10 column volume linear gradient ranging from 0.2 M NaCl, 50 mM sodium acetate, pH 6.0 to 1.0 M NaCl, 50 mM sodium acetate, pH 6.5. Fractions are collected under constant A₂₈₀ monitoring of the effluent. Fractions containing the polypeptide (determined, for instance, by 16% SDS-PAGE) are then pooled.

[0981] The resultant polypeptide should exhibit greater than 95% purity after the above refolding and purification steps. No major contaminant bands should be observed from Commassie blue stained 16% SDS-PAGE gel when 5 μg of purified protein is loaded. The purified protein can also be tested for endotoxin/LPS contamination, and typically the LPS content is less than 0.1 ng/ml according to LAL assays.

Example 7 Cloning and Expression of a Polypeptide in a Baculovirus Expression System

[0982] In this example, the plasmid shuttle vector pA2 is used to insert a polynucleotide into a baculovirus to express a polypeptide. This expression vector contains the strong polyhedrin promoter of the Autographa californica nuclear polyhedrosis virus (AcMNPV) followed by convenient restriction sites such as BamHI, Xba I and Asp718. The polyadenylation site of the simian virus 40 (“SV40”) is used for efficient polyadenylation. For easy selection of recombinant virus, the plasmid contains the beta-galactosidase gene from E. coli under control of a weak Drosophila promoter in the same orientation, followed by the polyadenylation signal of the polyhedrin gene. The inserted genes are flanked on both sides by viral sequences for cell-mediated homologous recombination with wild-type viral DNA to generate a viable virus that express the cloned polynucleotide.

[0983] Many other baculovirus vectors can be used in place of the vector above, such as pAc373, pVL941, and pAcIM1, as one skilled in the art would readily appreciate, as long as the construct provides appropriately located signals for transcription, translation, secretion and the like, including a signal peptide and an in-frame AUG as required. Such vectors are described, for instance, in Luckow et al., Virology 170:31-39 (1989).

[0984] Specifically, the cDNA sequence contained in the deposited clone, including the AUG initiation codon, is amplified using the PCR protocol described in Example 1. If a naturally occurring signal sequence is used to produce the polypeptide of the present invention, the pA2 vector does not need a second signal peptide. Alternatively, the vector can be modified (pA2 GP) to include a baculovirus leader sequence, using the standard methods described in Summers et al., “A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures,” Texas Agricultural Experimental Station Bulletin No. 1555 (1987).

[0985] The amplified fragment is isolated from a 1% agarose gel using a commercially available kit (“Geneclean,” BIO 101 Inc., La Jolla, Calif.). The fragment then is digested with appropriate restriction enzymes and again purified on a 1% agarose gel.

[0986] The plasmid is digested with the corresponding restriction enzymes and optionally, can be dephosphorylated using calf intestinal phosphatase, using routine procedures known in the art. The DNA is then isolated from a 1% agarose gel using a commercially available kit (“Geneclean” BIO 101 Inc., La Jolla, Calif.).

[0987] The fragment and the dephosphorylated plasmid are ligated together with T4 DNA ligase. E. coli HB101 or other suitable E. coli hosts such as XL-1 Blue (Stratagene Cloning Systems, La Jolla, Calif.) cells are transformed with the ligation mixture and spread on culture plates. Bacteria containing the plasmid are identified by digesting DNA from individual colonies and analyzing the digestion product by gel electrophoresis. The sequence of the cloned fragment is confirmed by DNA sequencing.

[0988] Five μg of a plasmid containing the polynucleotide is co-transfected with 1.0 μg of a commercially available linearized baculovirus DNA (“BaculoGold™ baculovirus DNA”, Pharmingen, San Diego, Calif.), using the lipofection method described by Felgner et al., Proc. Natl. Acad. Sci. USA 84:7413-7417 (1987). One μg of BaculoGold™ virus DNA and 5 μg of the plasmid are mixed in a sterile well of a microtiter plate containing 50 μl of serum-free Grace's medium (Life Technologies Inc., Gaithersburg, Md.). Afterwards, 10 μl Lipofectin plus 90 μl Grace's medium are added, mixed and incubated for 15 minutes at room temperature. Then the transfection mixture is added drop-wise to Sf9 insect cells (ATCC CRL 1711) seeded in a 35 mm tissue culture plate with 1 ml Grace's medium without serum. The plate is then incubated for 5 hours at 27° C. The transfection solution is then removed from the plate and 1 ml of Grace's insect medium supplemented with 10% fetal calf serum is added. Cultivation is then continued at 27° C. for four days.

[0989] After four days the supernatant is collected and a plaque assay is performed, as described by Summers and Smith, supra. An agarose gel with “Blue Gal” (Life Technologies Inc., Gaithersburg) is used to allow easy identification and isolation of gal-expressing clones, which produce blue-stained plaques. (A detailed description of a “plaque assay” of this type can also be found in the user's guide for insect cell culture and baculovirology distributed by Life Technologies Inc., Gaithersburg, page 9-10.) After appropriate incubation, blue stained plaques are picked with the tip of a micropipettor (e.g., Eppendorf). The agar containing the recombinant viruses is then resuspended in a microcentrifuge tube containing 200 μl of Grace's medium and the suspension containing the recombinant baculovirus is used to infect Sf9 cells seeded in 35 mm dishes. Four days later the supernatants of these culture dishes are harvested and then they are stored at 4° C.

[0990] To verify the expression of the polypeptide, Sf9 cells are grown in Grace's medium supplemented with 10% heat-inactivated FBS. The cells are infected with the recombinant baculovirus containing the polynucleotide at a multiplicity of infection (“MOI”) of about 2. If radiolabeled proteins are desired, 6 hours later the medium is removed and is replaced with SF900 II medium minus methionine and cysteine (available from Life Technologies Inc., Rockville, Md.). After 42 hours, 5 μCi of ³⁵S-methionine and 5 μCi ³⁵S-cysteine (available from Amersham) are added. The cells are further incubated for 16 hours and then are harvested by centrifugation. The proteins in the supernatant as well as the intracellular proteins are analyzed by SDS-PAGE followed by autoradiography (if radiolabeled).

[0991] Microsequencing of the amino acid sequence of the amino terminus of purified protein may be used to determine the amino terminal sequence of the produced protein.

Example 8 Expression of a Polypeptide in Mammalian Cells

[0992] The polypeptide of the present invention can be expressed in a mammalian cell. A typical mammalian expression vector contains a promoter element, which mediates the initiation of transcription of MRNA, a protein coding sequence, and signals required for the termination of transcription and polyadenylation of the transcript. Additional elements include enhancers, Kozak sequences and intervening sequences flanked by donor and acceptor sites for RNA splicing. Highly efficient transcription is achieved with the early and late promoters from SV40, the long terminal repeats (LTRs) from Retroviruses, e.g., RSV, HTLVI, HIVI and the early promoter of the cytomegalovirus (CMV). However, cellular elements can also be used (e.g., the human actin promoter).

[0993] Suitable expression vectors for use in practicing the present invention include, for example, vectors such as pSVL and pMSG (Pharmacia, Uppsala, Sweden), pRSVcat (ATCC 37152), pSV2dhfr (ATCC 37146), pBC12MI (ATCC 67109), pCMVSport 2.0, and pCMVSport 3.0. Mammalian host cells that could be used include, human Hela, 293, H9 and Jurkat cells, mouse NIH3T3 and C127 cells, Cos 1, Cos 7 and CVI, quail QC1-3 cells, mouse L cells and Chinese hamster ovary (CHO) cells.

[0994] Alternatively, the polypeptide can be expressed in stable cell lines containing the polynucleotide integrated into a chromosome. The co-transfection with a selectable marker such as DHFR, gpt, neomycin, or hygromycin allows the identification and isolation of the transfected cells.

[0995] The transfected gene can also be amplified to express large amounts of the encoded protein. The DHFR (dihydrofolate reductase) marker is useful in developing cell lines that carry several hundred or even several thousand copies of the gene of interest. (See, e.g., Alt, F. W., et al., J. Biol. Chem. 253:1357-1370 (1978); Hamlin, J. L. and Ma, C., Biochem. et Biophys. Acta, 1097:107-143 (1990); Page, M. J. and Sydenham, M. A., Biotechnology 9:64-68 (1991).) Another useful selection marker is the enzyme glutamine synthase (GS) (Murphy et al., Biochem J. 227:277-279 (1991); Bebbington et al., Bio/Technology 10:169-175 (1992). Using these markers, the mammalian cells are grown in selective medium and the cells with the highest resistance are selected. These cell lines contain the amplified gene(s) integrated into a chromosome. Chinese hamster ovary (CHO) and NSO cells are often used for the production of proteins.

[0996] Derivatives of the plasmid pSV2-dhfr (ATCC Accession No. 37146), the expression vectors pC4 (ATCC Accession No. 209646) and pC6 (ATCC Accession No.209647) contain the strong promoter (LTR) of the Rous Sarcoma Virus (Cullen et al., Molecular and Cellular Biology, 438-447 (March, 1985)) plus a fragment of the CMV-enhancer (Boshart et al., Cell 41:521-530 (1985).) Multiple cloning sites, e.g., with the restriction enzyme cleavage sites BamHI, XbaI and Asp718, facilitate the cloning of the gene of interest. The vectors also contain the 3′ intron, the polyadenylation and termination signal of the rat preproinsulin gene, and the mouse DHFR gene under control of the SV40 early promoter.

[0997] Specifically, the plasmid pC6, for example, is digested with appropriate restriction enzymes and then dephosphorylated using calf intestinal phosphates by procedures known in the art. The vector is then isolated from a 1% agarose gel.

[0998] A polynucleotide of the present invention is amplified according to the protocol outlined in Example 1. If a naturally occurring signal sequence is used to produce the polypeptide of the present invention, the vector does not need a second signal peptide. Alternatively, if a naturally occurring signal sequence is not used, the vector can be modified to include a heterologous signal sequence. (See, e.g., International Publication No. WO 96/34891.)

[0999] The amplified fragment is isolated from a 1% agarose gel using a commercially available kit (“Geneclean,” BIO 101 Inc., La Jolla, Calif.). The fragment then is digested with appropriate restriction enzymes and again purified on a 1% agarose gel.

[1000] The amplified fragment is then digested with the same restriction enzyme and purified on a 1% agarose gel. The isolated fragment and the dephosphorylated vector are then ligated with T4 DNA ligase. E. Coli HB11 or XL-1 Blue cells are then transformed and bacteria are identified that contain the fragment inserted into plasmid pC6 using, for instance, restriction enzyme analysis.

[1001] Chinese hamster ovary cells lacking an active DHFR gene is used for transfection. Five μg of the expression plasmid pC6 or pC4 is cotransfected with 0.5 μg of the plasmid pSVneo using lipofectin (Felgner et al., supra). The plasmid pSV2-neo contains a dominant selectable marker, the neo gene from Tn5 encoding an enzyme that confers resistance to a group of antibiotics including G418. The cells are seeded in alpha minus MEM supplemented with 1 mg/ml G418. After 2 days, the cells are trypsinized and seeded in hybridoma cloning plates (Greiner, Germany) in alpha minus MEM supplemented with 10, 25, or 50 ng/ml of methotrexate plus 1 mg/ml G418. After about 10-14 days single clones are trypsinized and then seeded in 6-well petri dishes or 10 ml flasks using different concentrations of methotrexate (50 nM, 100 nM, 200 nM, 400 nM, 800 nM). Clones growing at the highest concentrations of methotrexate are then transferred to new 6-well plates containing even higher concentrations of methotrexate (1 μM, 2 μM, 5 μM, 10 mM, 20 mM). The same procedure is repeated until clones are obtained which grow at a concentration of 100-200 μM. Expression of the desired gene product is analyzed, for instance, by SDS-PAGE and Western blot or by reversed phase HPLC analysis.

Example 9 Protein Fusions

[1002] The polypeptides of the present invention are preferably fused to other proteins. These fusion proteins can be used for a variety of applications. For example, fusion of the present polypeptides to His-tag, HA-tag, protein A, IgG domains, and maltose binding protein facilitates purification. (See Example 5; see also EP A 394,827; Traunecker, et al., Nature 331:84-86 (1988).) Similarly, fusion to IgG-1, IgG-3, and albumin increases the halflife time in vivo. Nuclear localization signals fused to the polypeptides of the present invention can target the protein to a specific subcellular localization, while covalent heterodimer or homodimers can increase or decrease the activity of a fusion protein. Fusion proteins can also create chimeric molecules having more than one function. Finally, fusion proteins can increase solubility and/or stability of the fused protein compared to the non-fused protein. All of the types of fusion proteins described above can be made by modifying the following protocol, which outlines the fusion of a polypeptide to an IgG molecule, or the protocol described in Example 5.

[1003] Briefly, the human Fc portion of the IgG molecule can be PCR amplified, using primers that span the 5′ and 3′ ends of the sequence described below. These primers also should have convenient restriction enzyme sites that will facilitate cloning into an expression vector, preferably a mammalian expression vector.

[1004] For example, if pC4 (ATCC Accession No. 209646) is used, the human Fc portion can be ligated into the BamHI cloning site. Note that the 3′ BamHI site should be destroyed. Next, the vector containing the human Fc portion is re-restricted with BamHl, linearizing the vector, and a polynucleotide of the present invention, isolated by the PCR protocol described in Example 1, is ligated into this BamHI site. Note that the polynucleotide is cloned without a stop codon, otherwise a fusion protein will not be produced.

[1005] If the naturally occurring signal sequence is used to produce the polypeptide of the present invention, pC4 does not need a second signal peptide. Alternatively, if the naturally occurring signal sequence is not used, the vector can be modified to include a heterologous signal sequence. (See, e.g., International Publication No. WO 96/34891.) GGGATCCGGAGCCCAAATCTTCTGACAAAACTCACAC (SEQ ID NO:1) ATGCCCACCGTGCCCAGCACCTGAATTCGAGGGTGCA CCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACTCCTGAGGTCACATGCGT GGTGGTGGACGTAAGCCACGAAGACCCTGAGGTCAAG TTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCAC GTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAG GACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCT CCAACAAAGCCCTCCCAACCCCCATCGAGAAAACCAT CTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTG TACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGA ACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTA TCCAAGCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGC TGGACTCCGACGGCTCCTTCTTCCTCTACAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTC TTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACC ACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA ATGAGTGCGACGGCCGCGACTCTAGAGGAT

Example 10 Production of an Antibody from a Polypeptide

[1006] Hybridoma Technology

[1007] The antibodies of the present invention can be prepared by a variety of methods. (See, Current Protocols, Chapter 2.) As one example of such methods, cells expressing polypeptide of the present invention are administered to an animal to induce the production of sera containing polyclonal antibodies. In a preferred method, a preparation of polypeptide of the present invention is prepared and purified to render it substantially free of natural contaminants. Such a preparation is then introduced into an animal in order to produce polyclonal antisera of greater specific activity.

[1008] Monoclonal antibodies specific for polypeptide of the present invention are prepared using hybridoma technology (Kohler et al., Nature 256:495 (1975); Kohler et al., Eur. J. Immunol. 6:511 (1976); Kohler et al., Eur. J. Inmunol. 6:292 (1976); Hammerling et al., in: Monoclonal Antibodies and T-Cell Hybridomas, Elsevier, N.Y., pp. 563-681 (1981)). In general, an animal (preferably a mouse) is immunized with polypeptide of the present invention or, more preferably, with a secreted polypeptide of the present invention-expressing cell. Such polypeptide-expressing cells are cultured in any suitable tissue culture medium, preferably in Earle's modified Eagle's medium supplemented with 10% fetal bovine serum (inactivated at about 56° C.), and supplemented with about 10 g/l of nonessential amino acids, about 1,000 U/ml of penicillin, and about 100 μg/ml of streptomycin.

[1009] The splenocytes of such mice are extracted and fused with a suitable myeloma cell line. Any suitable myeloma cell line may be employed in accordance with the present invention; however, it is preferable to employ the parent myeloma cell line (SP2O), available from the ATCC. After fusion, the resulting hybridoma cells are selectively maintained in HAT medium, and then cloned by limiting dilution as described by Wands et al. (Gastroenterology 80:225-232 (1981)). The hybridoma cells obtained through such a selection are then assayed to identify clones which secrete antibodies capable of binding the polypeptide of the present invention.

[1010] Alternatively, additional antibodies capable of binding to polypeptide of the present invention can be produced in a two-step procedure using anti-idiotypic antibodies. Such a method makes use of the fact that antibodies are themselves antigens, and therefore, it is possible to obtain an antibody which binds to a second antibody. In accordance with this method, protein specific antibodies are used to immunize an animal, preferably a mouse. The splenocytes of such an animal are then used to produce hybridoma cells, and the hybridoma cells are screened to identify clones which produce an antibody whose ability to bind to the polypeptide of the present invention-specific antibody can be blocked by polypeptide of the present invention. Such antibodies comprise anti-idiotypic antibodies to the polypeptide of the present invention-specific antibody and are used to immunize an animal to induce formation of further polypeptide of the present invention-specific antibodies.

[1011] For in vivo use of antibodies in humans, an antibody is “humanized”. Such antibodies can be produced using genetic constructs derived from hybridoma cells producing the monoclonal antibodies described above. Methods for producing chimeric and humanized antibodies are known in the art and are discussed herein. (See, for review, Morrison, Science 229:1202 (1985); Oi et al., BioTechniques 4:214 (1986); Cabilly et al., U.S. Pat. No. 4,816,567; Taniguchi et al., EP 171496;

[1012] Morrison et al., EP 173494; Neuberger et al., WO 8601533; Robinson et al., International Publication No. WO 8702671; Boulianne et al., Nature 312:643 (1984);

[1013] Neuberger et al., Nature 314:268 (1985).)

[1014] Isolation Of Antibody Fragments Directed Against Polypeptide of the Present Invention From A Library Of scFvs

[1015] Naturally occurring V-genes isolated from human PBLs are constructed into a library of antibody fragments which contain reactivities against polypeptide of the present invention to which the donor may or may not have been exposed (see e.g., U.S. Pat. No. 5,885,793 incorporated herein by reference in its entirety).

[1016] Rescue of the Library. A library of scFvs is constructed from the RNA of human PBLs as described in International Publication No. WO 92/01047. To rescue phage displaying antibody fragments, approximately 109 E. coli harboring the phagemid are used to inoculate 50 ml of 2×TY containing 1% glucose and 100 μg/ml of ampicillin (2×TY-AMP-GLU) and grown to an O.D. of 0.8 with shaking. Five ml of this culture is used to inoculate 50 ml of 2×TY-AMP-GLU, 2×108 TU of delta gene 3 helper (M13 delta gene III, see International Publication No. WO 92/01047) are added and the culture incubated at 37° C. for 45 minutes without shaking and then at 37° C. for 45 minutes with shaking. The culture is centrifuged at 4000 r.p.m. for 10 min. and the pellet resuspended in 2 liters of 2×TY containing 100 μg/ml ampicillin and 50 ug/ml kanamycin and grown overnight. Phage are prepared as described in International Application No. WO 92/01047.

[1017] M13 delta gene III is prepared as follows: M13 delta gene III helper phage does not encode gene III protein, hence the phage(mid) displaying antibody fragments have a greater avidity of binding to antigen. Infectious M13 delta gene III particles are made by growing the helper phage in cells harboring a pUC19 derivative supplying the wild type gene III protein during phage morphogenesis. The culture is incubated for 1 hour at 37° C. without shaking and then for a further hour at 37° C. with shaking. Cells are spun down (IEC-Centra 8,400 r.p.m. for 10 min), resuspended in 300 ml 2×TY broth containing 100 μg ampicillin/ml and 25 μg kanamycin/ml (2×TY-AMP-KAN) and grown overnight, shaking at 37° C. Phage particles are purified and concentrated from the culture medium by two PEG-precipitations (Sambrook et al., 1990), resuspended in 2 ml PBS and passed through a 0.45 μm filter (Minisart NML;

[1018] Sartorius) to give a final concentration of approximately 10¹³ transducing units/ml (ampicillin-resistant clones).

[1019] Panning of the Library. Immunotubes (Nunc) are coated overnight in PBS with 4 ml of either 100 μg/ml or 10 μg/ml of a polypeptide of the present invention.

[1020] Tubes are blocked with 2% Marvel-PBS for 2 hours at 37° C. and then washed 3 times in PBS. Approximately 10¹³ TU of phage is applied to the tube and incubated for 30 minutes at room temperature tumbling on an over and under turntable and then left to stand for another 1.5 hours. Tubes are washed 10 times with PBS 0.1% Tween-20 and 10 times with PBS. Phage are eluted by adding 1 ml of 100 mM triethylamine and rotating 15 minutes on an under and over turntable after which the solution is immediately neutralized with 0.5 ml of 1.0M Tris-HCl, pH 7.4. Phage are then used to infect 10 ml of mid-log E. coli TG1 by incubating eluted phage with bacteria for 30 minutes at 37° C. The E. coli are then plated on TYE plates containing 1% glucose and 100 μg/ml ampicillin. The resulting bacterial library is then rescued with delta gene 3 helper phage as described above to prepare phage for a subsequent round of selection. This process is then repeated for a total of 4 rounds of affinity purification with tube-washing increased to 20 times with PBS, 0.1% Tween-20 and 20 times with PBS for rounds 3 and 4.

[1021] Characterization of Binders. Eluted phage from the 3rd and 4th rounds of selection are used to infect E. coli HB 2151 and soluble scFv is produced (Marks, et al., 1991) from single colonies for assay. ELISAs are performed with microtitre plates coated with 10 pg/ml of the polypeptide of the present invention in 50 mM bicarbonate pH 9.6. Clones positive in ELISA are further characterized by PCR fingerprinting (see, e.g., International Application No. WO 92/01047) and then by sequencing. These ELISA positive clones may also be further characterized by techniques known in the art, such as, for example, epitope mapping, binding affinity, receptor signal transduction, ability to block or competitively inhibit antibody/antigen binding, and competitive agonistic or antagonistic activity.

Example 11 Method of Determining Alterations in a Gene Corresponding to a Polynucleotide

[1022] RNA isolated from entire families or individual patients presenting with a phenotype of interest (such as a disease) is isolated. cDNA is then generated from these RNA samples using protocols known in the art. (See, Sambrook.) The cDNA is then used as a template for PCR, employing primers surrounding regions of interest in SEQ ID NO: X; and/or the nucleotide sequence of the cDNA contained in Clone ID NO: Z. Suggested PCR conditions consist of 35 cycles at 95 degrees C. for 30 seconds; 60-120 seconds at 52-58 degrees C.; and 60-120 seconds at 70 degrees C., using buffer solutions described in Sidransky et al., Science 252:706 (1991).

[1023] PCR products are then sequenced using primers labeled at their 5′ end with T4 polynucleotide kinase, employing SequiTherm Polymerase (Epicentre Technologies). The intron-exon boundaries of selected exons is also determined and genomic PCR products analyzed to confirm the results. PCR products harboring suspected mutations are then cloned and sequenced to validate the results of the direct sequencing.

[1024] PCR products are cloned into T-tailed vectors as described in Holton et al., Nucleic Acids Research, 19:1156 (1991) and sequenced with T7 polymerase (United States Biochemical). Affected individuals are identified by mutations not present in unaffected individuals.

[1025] Genomic rearrangements are also observed as a method of determining alterations in a gene corresponding to a polynucleotide. Genomic clones isolated according to Example 2 are nick-translated with digoxigenindeoxy-uridine 5′-triphosphate (Boehringer Manheim), and FISH performed as described in Johnson et al., Methods Cell Biol. 35:73-99 (1991). Hybridization with the labeled probe is carried out using a vast excess of human cot-i DNA for specific hybridization to the corresponding genomic locus.

[1026] Chromosomes are counterstained with 4,6-diamino-2-phenylidole and propidium iodide, producing a combination of C- and R-bands. Aligned images for precise mapping are obtained using a triple-band filter set (Chroma Technology, Brattleboro, Vt.) in combination with a cooled charge-coupled device camera (Photometrics, Tucson, Ariz.) and variable excitation wavelength filters. (Johnson et al., Genet. Anal. Tech. Appl., 8:75 (1991).) Image collection, analysis and chromosomal fractional length measurements are performed using the ISee Graphical Program System. (Inovision Corporation, Durham, N.C.) Chromosome alterations of the genomic region hybridized by the probe are identified as insertions, deletions, and translocations. These alterations are used as a diagnostic marker for an associated disease.

Example 12 Method of Detecting Abnormal Levels of a Polypeptide in a Biological Sample

[1027] A polypeptide of the present invention can be detected in a biological sample, and if an increased or decreased level of the polypeptide is detected, this polypeptide is a marker for a particular phenotype. Methods of detection are numerous, and thus, it is understood that one skilled in the art can modify the following assay to fit their particular needs.

[1028] For example, antibody-sandwich ELISAs are used to detect polypeptides in a sample, preferably a biological sample. Wells of a microtiter plate are coated with specific antibodies, at a final concentration of 0.2 to 10 ug/ml. The antibodies are either monoclonal or polyclonal and are produced by the method described in Example 10. The wells are blocked so that non-specific binding of the polypeptide to the well is reduced.

[1029] The coated wells are then incubated for >2 hours at RT with a sample containing the polypeptide. Preferably, serial dilutions of the sample should be used to validate results. The plates are then washed three times with deionized or distilled water to remove unbound polypeptide.

[1030] Next, 50 ul of specific antibody-alkaline phosphatase conjugate, at a concentration of 25-400 ng, is added and incubated for 2 hours at room temperature. The plates are again washed three times with deionized or distilled water to remove unbound conjugate.

[1031] Add 75 ul of 4-methylumbelliferyl phosphate (MUP) or p-nitrophenyl phosphate (NPP) substrate solution to each well and incubate 1 hour at room temperature. Measure the reaction by a microtiter plate reader. Prepare a standard curve, using serial dilutions of a control sample, and plot polypeptide concentration on the X-axis (log scale) and fluorescence or absorbance of the Y-axis (linear scale). Interpolate the concentration of the polypeptide in the sample using the standard curve.

Example 13 Formulation

[1032] The invention also provides methods of treatment and/or prevention of diseases or disorders (such as, for example, any one or more of the diseases or disorders disclosed herein) by administration to a subject of an effective amount of a Therapeutic. By “Therapeutic” is meant polynucleotides or polypeptides of the invention (including fragments, analogs, derivatives and variants thereof), agonists or antagonists thereof, and/or antibodies thereto (including fragments thereof), in combination with a pharmaceutically acceptable carrier type (e.g., a sterile carrier).

[1033] The Therapeutic will be formulated and dosed in a fashion consistent with good medical practice, taking into account the clinical condition of the individual patient (especially the side effects of treatment with the Therapeutic alone), the site of delivery, the method of administration, the scheduling of administration, and other factors known to practitioners. The “effective amount” for purposes herein is thus determined by such considerations.

[1034] As a general proposition, the total pharmaceutically effective amount of the Therapeutic administered parenterally per dose will be in the range of about 1 ug/kg/day to 10 mg/kg/day of patient body weight, although, as noted above, this will be subject to therapeutic discretion. More preferably, this dose is at least 0.01 mg/kg/day, and most preferably for humans between about 0.01 and 1 mg/kg/day for the hormone. If given continuously, the Therapeutic is typically administered at a dose rate of about 1 ug/kg/hour to about 50 ug/kg/hour, either by 1-4 injections per day or by continuous subcutaneous infusions, for example, using a mini-pump. An intravenous bag solution may also be employed. The length of treatment needed to observe changes and the interval following treatment for responses to occur appears to vary depending on the desired effect.

[1035] Therapeutics can be are administered orally, rectally, parenterally, intracistemally, intravaginally, intraperitoneally, topically (as by powders, ointments, gels, drops or transdermal patch), bucally, or as an oral or nasal spray. “Pharmaceutically acceptable carrier” refers to a non-toxic solid, semisolid or liquid filler, diluent, encapsulating material or formulation auxiliary of any. The term “parenteral” as used herein refers to modes of administration which include intravenous, intramuscular, intraperitoneal, intrastemal, subcutaneous and intraarticular injection and infusion.

[1036] Therapeutics of the invention are also suitably administered by sustained-release systems. Suitable examples of sustained-release Therapeutics are administered orally, rectally, parenterally, intracistemally, intravaginally, intraperitoneally, topically (as by powders, ointments, gels, drops or transdermal patch), bucally, or as an oral or nasal spray. “Pharmaceutically acceptable carrier” refers to a non-toxic solid, semisolid or liquid filler, diluent, encapsulating material or formulation auxiliary of any type. The term “parenteral” as used herein refers to modes of administration which include intravenous, intramuscular, intraperitoneal, intrasternal, subcutaneous and intraarticular injection and infusion.

[1037] Therapeutics of the invention are also suitably administered by sustained-release systems. Suitable examples of sustained-release Therapeutics include suitable polymeric materials (such as, for example, semi-permeable polymer matrices in the form of shaped articles, e.g., films, or mirocapsules), suitable hydrophobic materials (for example as an emulsion in an acceptable oil) or ion exchange resins, and sparingly soluble derivatives (such as, for example, a sparingly soluble salt).

[1038] Sustained-release matrices include polylactides (U.S. Pat. No. 3,773,919, EP 58,481), copolymers of L-glutamic acid and gamma-ethyl-L-glutamate (Sidman et al., Biopolymers 22:547-556 (1983)), poly (2-hydroxyethyl methacrylate) (Langer et al., J. Biomed. Mater. Res. 15:167-277 (1981), and Langer, Chem. Tech. 12:98-105 (1982)), ethylene vinyl acetate (Langer et al., Id.) or poly-D-(−)-3-hydroxybutyric acid (EP 133,988).

[1039] Sustained-release Therapeutics also include liposomally entrapped Therapeutics of the invention (see generally, Langer, Science 249:1527-1533 (1990); Treat et al., in Liposomes in the Therapy of Infectious Disease and Cancer, Lopez-Berestein and Fidler (eds.), Liss, N.Y., pp. 317-327 and 353-365 (1989)). Liposomes containing the Therapeutic are prepared by methods known per se: DE 3,218,121; Epstein et al., Proc. Natl. Acad. Sci. (USA) 82:3688-3692 (1985); Hwang et al., Proc. Natl. Acad. Sci.(USA) 77:4030-4034 (1980); EP 52,322; EP 36,676; EP 88,046; EP 143,949; EP 142,641; Japanese Pat. Appl. 83-118008; U.S. Pat. Nos. 4,485,045 and 4,544,545; and EP 102,324. Ordinarily, the liposomes are of the small (about 200-800 Angstroms) unilamellar type in which the lipid content is greater than about 30 mol. percent cholesterol, the selected proportion being adjusted for the optimal Therapeutic.

[1040] In yet an additional embodiment, the Therapeutics of the invention are delivered by way of a pump (see Langer, supra; Sefton, CRC Crit. Ref. Biomed. Eng. 14:201 (1987); Buchwald et al., Surgery 88:507 (1980); Saudek et al., N. Engl. J. Med. 321:574 (1989)).

[1041] Other controlled release systems are discussed in the review by Langer (Science 249:1527-1533 (1990)).

[1042] For parenteral administration, in one embodiment, the Therapeutic is formulated generally by mixing it at the desired degree of purity, in a unit dosage injectable form (solution, suspension, or emulsion), with a pharmaceutically acceptable carrier, i.e., one that is non-toxic to recipients at the dosages and concentrations employed and is compatible with other ingredients of the formulation. For example, the formulation preferably does not include oxidizing agents and other compounds that are known to be deleterious to the Therapeutic.

[1043] Generally, the formulations are prepared by contacting the Therapeutic uniformly and intimately with liquid carriers or finely divided solid carriers or both. Then, if necessary, the product is shaped into the desired formulation. Preferably the carrier is a parenteral carrier, more preferably a solution that is isotonic with the blood of the recipient. Examples of such carrier vehicles include water, saline, Ringer's solution, and dextrose solution. Non-aqueous vehicles such as fixed oils and ethyl oleate are also useful herein, as well as liposomes.

[1044] The carrier suitably contains minor amounts of additives such as substances that enhance isotonicity and chemical stability. Such materials are non-toxic to recipients at the dosages and concentrations employed, and include buffers such as phosphate, citrate, succinate, acetic acid, and other organic acids or their salts; antioxidants such as ascorbic acid; low molecular weight (less than about ten residues) polypeptides, e.g., polyarginine or tripeptides; proteins, such as serum albumin, gelatin, or immunoglobulins; hydrophilic polymers such as polyvinylpyrrolidone; amino acids, such as glycine, glutamic acid, aspartic acid, or arginine; monosaccharides, disaccharides, and other carbohydrates including cellulose or its derivatives, glucose, manose, or dextrins; chelating agents such as EDTA; sugar alcohols such as mannitol or sorbitol; counterions such as sodium; and/or nonionic surfactants such as polysorbates, poloxamers, or PEG.

[1045] The Therapeutic is typically formulated in such vehicles at a concentration of about 0.1 mg/ml to 100 mg/ml, preferably 1-10 mg/ml, at a pH of about 3 to 8. It will be understood that the use of certain of the foregoing excipients, carriers, or stabilizers will result in the formation of polypeptide salts.

[1046] Any pharmaceutical used for therapeutic administration can be sterile. Sterility is readily accomplished by filtration through sterile filtration membranes (e.g., 0.2 micron membranes). Therapeutics generally are placed into a container having a sterile access port, for example, an intravenous solution bag or vial having a stopper pierceable by a hypodermic injection needle.

[1047] Therapeutics ordinarily will be stored in unit or multi-dose containers, for example, sealed ampoules or vials, as an aqueous solution or as a lyophilized formulation for reconstitution. As an example of a lyophilized formulation, 10-ml vials are filled with 5 ml of sterile-filtered 1% (w/v) aqueous Therapeutic solution, and the resulting mixture is lyophilized. The infusion solution is prepared by reconstituting the lyophilized Therapeutic using bacteriostatic Water-for-Injection.

[1048] The invention also provides a pharmaceutical pack or kit comprising one or more containers filled with one or more of the ingredients of the Therapeutics of the invention. Associated with such container(s) can be a notice in the form prescribed by a governmental agency regulating the manufacture, use or sale of pharmaceuticals or biological products, which notice reflects approval by the agency of manufacture, use or sale for human administration. In addition, the Therapeutics may be employed in conjunction with other therapeutic compounds.

[1049] The Therapeutics of the invention may be administered alone or in combination with adjuvants. Adjuvants that may be administered with the Therapeutics of the invention include, but are not limited to, alum, alum plus deoxycholate (ImmunoAg), MTP-PE (Biocine Corp.), QS21 (Genentech, Inc.), BCG, and MPL. In a specific embodiment, Therapeutics of the invention are administered in combination with alum. In another specific embodiment, Therapeutics of the invention are administered in combination with QS-21. Further adjuvants that may be administered with the Therapeutics of the invention include, but are not limited to, Monophosphoryl lipid immunomodulator, AdjuVax 100a, QS-21, QS-18, CRL1005, Aluminum salts, MF-59, and Virosomal adjuvant technology. Vaccines that may be administered with the Therapeutics of the invention include, but are not limited to, vaccines directed toward protection against MMR (measles, mumps, rubella), polio, varicella, tetanus/diptheria, hepatitis A, hepatitis B, haemophilus influenzae B, whooping cough, pneumonia, influenza, Lyme's Disease, rotavirus, cholera, yellow fever, Japanese encephalitis, poliomyelitis, rabies, typhoid fever, and pertussis. Combinations may be administered either concomitantly, e.g., as an admixture, separately but simultaneously or concurrently; or sequentially. This includes presentations in which the combined agents are administered together as a therapeutic mixture, and also procedures in which the combined agents are administered separately but simultaneously, e.g., as through separate intravenous lines into the same individual. Administration “in combination” further includes the separate administration of one of the compounds or agents given first, followed by the second.

[1050] The Therapeutics of the invention may be administered alone or in combination with other therapeutic agents. Therapeutic agents that may be administered in combination with the Therapeutics of the invention, include but not limited to, other members of the TNF family, chemotherapeutic agents, antibiotics, steroidal and non-steroidal anti-inflammatories, conventional immunotherapeutic agents, cytokines and/or growth factors. Combinations may be administered either concomitantly, e.g., as an admixture, separately but simultaneously or concurrently; or sequentially. This includes presentations in which the combined agents are administered together as a therapeutic mixture, and also procedures in which the combined agents are administered separately but simultaneously, e.g., as through separate intravenous lines into the same individual. Administration “in combination” further includes the separate administration of one of the compounds or agents given first, followed by the second.

[1051] In one embodiment, the Therapeutics of the invention are administered in combination with members of the TNF family. TNF, TNF-related or TNF-like molecules that may be administered with the Therapeutics of the invention include, but are not limited to, soluble forms of TNF-alpha, lymphotoxin-alpha (LT-alpha, also known as TNF-beta), LT-beta (found in complex heterotrimer LT-alpha2-beta), OPGL, FasL, CD27L, CD30L, CD40L, 4-1BBL, DcR3, OX40L, TNF-gamma (International Publication No. WO 96/14328), AIM-I (International Publication No. WO 97/33899), endokine-alpha (International Publication No. WO 98/07880), TR6 (International Publication No. WO 98/30694), OPG, and neutrokine-alpha (International Publication No. WO 98/18921, OX40, and nerve growth factor (NGF), and soluble forms of Fas, CD30, CD27, CD40 and 4-IBB, TR2 (International Publication No. WO 96/34095), DR3 (International Publication No. WO 97/33904), DR4 (International Publication No. WO 98/32856), TR5 (International Publication No. WO 98/30693), TR6 (International Publication No. WO 98/30694), TR7 (International Publication No. WO 98/41629), TRANK, TR9 (International Publication No. WO 98/56892),TR10 (International Publication No. WO 98/54202), 312C2 (International Publication No. WO 98/06842), and TR12, and soluble forms CD154, CD70, and CD153.

[1052] In certain embodiments, Therapeutics of the invention are administered in combination with antiretroviral agents, nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and/or protease inhibitors. Nucleoside reverse transcriptase inhibitors that may be administered in combination with the Therapeutics of the invention, include, but are not limited to, RETROVIR™ (zidovudine/AZT), VIDEX™ (didanosine/ddI), HIVID™ (zalcitabine/ddC), ZERIT™ (stavudine/d4T), EPIVIR™ (lamivudine/3TC), and COMBIVIR™ (zidovudine/lamivudine). Non-nucleoside reverse transcriptase inhibitors that may be administered in combination with the Therapeutics of the invention, include, but are not limited to, VIRAMUNE™ (nevirapine), RESCRIPTOR™ (delavirdine), and SUSTIVA™ (efavirenz). Protease inhibitors that may be administered in combination with the Therapeutics of the invention, include, but are not limited to, CRIXIVAN™ (indinavir), NORVIR™ (ritonavir), INVIRASE ™ (saquinavir), and VIRACEPT™ (nelfinavir). In a specific embodiment, antiretroviral agents, nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and/or protease inhibitors may be used in any combination with Therapeutics of the invention to treat AIDS and/or to prevent or treat HIV infection.

[1053] In other embodiments, Therapeutics of the invention may be administered in combination with anti-opportunistic infection agents. Anti-opportunistic agents that may be administered in combination with the Therapeutics of the invention, include, but are not limited to, TRIMETHOPRIM-SULFAMETHOXAZOLE™, DAPSONE™, PENTAMIDINE™, ATOVAQUONE™, ISONIAZID™, RIFAMPIN™, PYRAZINAMIDE™, ETHAMBUTOL™, RIFABUTIN™, CLARITHROMYCIN™, AZITHROMYCIN™, GANCICLOVIR™, FOSCARNET™, CIDOFOVIR™, FLUCONAZOLE™, ITRACONAZOLE™, KETOCONAZOLE™, ACYCLOVIR™, FAMCICOLVIR™, PYRIMETHAMINE™, LEUCOVORIN™, NEUPOGEN™ (filgrastim/G-CSF), and LEUKINE™ (sargramostim/GM-CSF). In a specific embodiment, Therapeutics of the invention are used in any combination with TRIMETHOPRIM-SULFAMETHOXAZOLE™, DAPSONE™, PENTAMIDINE™, and/or ATOVAQUONE™ to prophylactically treat or prevent an opportunistic Pneumocystis carinii pneumonia infection. In another specific embodiment, Therapeutics of the invention are used in any combination with ISONIAZID™, RIFAMPIN™, PYRAZINAMIDE™, and/or ETHAMBUTOL™ to prophylactically treat or prevent an opportunistic Mycobacterium avium complex infection. In another specific embodiment, Therapeutics of the invention are used in any combination with RIFABUTIN™, CLARITHROMYCIN™, and/or AZITHROMYCIN™ to prophylactically treat or prevent an opportunistic Mycobacterium tuberculosis infection. In another specific embodiment, Therapeutics of the invention are used in any combination with GANCICLOVIR™, FOSCARNET™, and/or CIDOFOVIR™ to prophylactically treat or prevent an opportunistic cytomegalovirus infection. In another specific embodiment, Therapeutics of the invention are used in any combination with FLUCONAZOLE™, ITRACONAZOLE™, and/or KETOCONAZOLE™ to prophylactically treat or prevent an opportunistic fungal infection. In another specific embodiment, Therapeutics of the invention are used in any combination with ACYCLOVIR™ and/or FAMCICOLVIR™ to prophylactically treat or prevent an opportunistic herpes simplex virus type I and/or type II infection. In another specific embodiment, Therapeutics of the invention are used in any combination with PYRIMETHAMINE™ and/or LEUCOVORIN™ to prophylactically treat or prevent an opportunistic Toxoplasma gondii infection. In another specific embodiment, Therapeutics of the invention are used in any combination with LEUCOVORIN™ and/or NEUPOGEN™ to prophylactically treat or prevent an opportunistic bacterial infection.

[1054] In a further embodiment, the Therapeutics of the invention are administered in combination with an antiviral agent. Antiviral agents that may be administered with the Therapeutics of the invention include, but are not limited to, acyclovir, ribavirin, amantadine, and remantidine.

[1055] In a further embodiment, the Therapeutics of the invention are administered in combination with an antibiotic agent. Antibiotic agents that may be administered with the Therapeutics of the invention include, but are not limited to, amoxicillin, beta-lactamases, aminoglycosides, beta-lactam (glycopeptide), beta-lactamases, Clindamycin, chloramphenicol, cephalosporins, ciprofloxacin, ciprofloxacin, erythromycin, fluoroquinolones, macrolides, metronidazole, penicillins, quinolones, rifampin, streptomycin, sulfonamide, tetracyclines, trimethoprim, trimethoprim-sulfamthoxazole, and vancomycin.

[1056] Conventional nonspecific immunosuppressive agents, that may be administered in combination with the Therapeutics of the invention include, but are not limited to, steroids, cyclosporine, cyclosporine analogs, cyclophosphamide methylprednisone, prednisone, azathioprine, FK-506, 15-deoxyspergualin, and other immunosuppressive agents that act by suppressing the function of responding T cells.

[1057] In specific embodiments, Therapeutics of the invention are administered in combination with immunosuppressants. Immunosuppressants preparations that may be administered with the Therapeutics of the invention include, but are not limited to, ORTHOCLONE™ (OKT3), SANDIMMUNE™/NEORAL™/SANGDYA™ (cyclosporin), PROGRAF™ (tacrolimus), CELLCEPT™ (mycophenolate), Azathioprine, glucorticosteroids, and RAPAMUNE™ (sirolimus). In a specific embodiment, immunosuppressants may be used to prevent rejection of organ or bone marrow transplantation.

[1058] In an additional embodiment, Therapeutics of the invention are administered alone or in combination with one or more intravenous immune globulin preparations. Intravenous immune globulin preparations that may be administered with the Therapeutics of the invention include, but not limited to, GAMMAR™, IVEEGAM™, SANDOGLOBULIN™, GAMMAGARD S/D™, and GAMIMUNE™. In a specific embodiment, Therapeutics of the invention are administered in combination with intravenous immune globulin preparations in transplantation therapy (e.g., bone marrow transplant).

[1059] In an additional embodiment, the Therapeutics of the invention are administered alone or in combination with an anti-inflammatory agent. Anti-inflammatory agents that may be administered with the Therapeutics of the invention include, but are not limited to, glucocorticoids and the nonsteroidal anti-inflammatories, aminoarylcarboxylic acid derivatives, arylacetic acid derivatives, arylbutyric acid derivatives, arylcarboxylic acids, arylpropionic acid derivatives, pyrazoles, pyrazolones, salicylic acid derivatives, thiazinecarboxamides, e-acetamidocaproic acid, S-adenosylmethionine, 3-amino-4-hydroxybutyric acid, amixetrine, bendazac, benzydamine, bucolome, difenpiramide, ditazol, emorfazone, guaiazulene, nabumetone, nimesulide, orgotein, oxaceprol, paranyline, perisoxal, pifoxime, proquazone, proxazole, and tenidap.

[1060] In an additional embodiment, the compositions of the invention are administered alone or in combination with an anti-angiogenic agent. Anti-angiogenic agents that may be administered with the compositions of the invention include, but are not limited to, Angiostatin (Entremed, Rockville, Md.), Troponin-1 (Boston Life Sciences, Boston, Mass.), anti-Invasive Factor, retinoic acid and derivatives thereof, paclitaxel (Taxol), Suramin, Tissue Inhibitor of Metalloproteinase-1, Tissue Inhibitor of Metalloproteinase-2, VEGI, Plasminogen Activator Inhibitor-1, Plasminogen Activator Inhibitor-2, and various forms of the lighter “d group” transition metals.

[1061] Lighter “d group” transition metals include, for example, vanadium, molybdenum, tungsten, titanium, niobium, and tantalum species. Such transition metal species may form transition metal complexes. Suitable complexes of the above-mentioned transition metal species include oxo transition metal complexes.

[1062] Representative examples of vanadium complexes include oxo vanadium complexes such as vanadate and vanadyl complexes. Suitable vanadate complexes include metavanadate and orthovanadate complexes such as, for example, ammonium metavanadate, sodium metavanadate, and sodium orthovanadate. Suitable vanadyl complexes include, for example, vanadyl acetylacetonate and vanadyl sulfate including vanadyl sulfate hydrates such as vanadyl sulfate mono- and trihydrates.

[1063] Representative examples of tungsten and molybdenum complexes also include oxo complexes. Suitable oxo tungsten complexes include tungstate and tungsten oxide complexes. Suitable tungstate complexes include ammonium tungstate, calcium tungstate, sodium tungstate dihydrate, and tungstic acid. Suitable tungsten oxides include tungsten (IV) oxide and tungsten (VI) oxide. Suitable oxo molybdenum complexes include molybdate, molybdenum oxide, and molybdenyl complexes. Suitable molybdate complexes include ammonium molybdate and its hydrates, sodium molybdate and its hydrates, and potassium molybdate and its hydrates. Suitable molybdenum oxides include molybdenum (VI) oxide, molybdenum (VI) oxide, and molybdic acid. Suitable molybdenyl complexes include, for example, molybdenyl acetylacetonate. Other suitable tungsten and molybdenum complexes include hydroxo derivatives derived from, for example, glycerol, tartaric acid, and sugars.

[1064] A wide variety of other anti-angiogenic factors may also be utilized within the context of the present invention. Representative examples include, but are not limited to, platelet factor 4; protamine sulphate; sulphated chitin derivatives (prepared from queen crab shells), (Murata et al., Cancer Res. 51:22-26 (1991)); Sulphated Polysaccharide Peptidoglycan Complex (SP-PG) (the function of this compound may be enhanced by the presence of steroids such as estrogen, and tamoxifen citrate); Staurosporine; modulators of matrix metabolism, including for example, proline analogs, cishydroxyproline, d,L-3,4-dehydroproline, Thiaproline, alpha,alpha-dipyridyl, aminopropionitrile fumarate; 4-propyl-5-(4-pyridinyl)-2(3H)-oxazolone; Methotrexate; Mitoxantrone; Heparin; Interferons; 2 Macroglobulin-serum; ChIMP-3 (Pavloff et al., J. Bio. Chem. 267:17321-17326, (1992)); Chymostatin (Tomkinson et al., Biochem J. 286:475-480 (1992)); Cyclodextrin Tetradecasulfate; Eponemycin;

[1065] Camptothecin; Fumagillin (Ingber et al., Nature 348:555-557, 1990); Gold Sodium Thiomalate (“GST”; Matsubara and Ziff, J. Clin. Invest. 79:1440-1446, 1987); anticollagenase-serum; alpha2-antiplasmin (Holmes et al., J. Biol. Chem. 262(4):1659-1664 (1987)); Bisantrene (National Cancer Institute); Lobenzarit disodium (N-(2)-carboxyphenyl-4-chloroanthronilic acid disodium or “CCA”; (Takeuchi et al., Agents Actions 36:312-316, 1992); and metalloproteinase inhibitors such as BB94.

[1066] Additional anti-angiogenic factors that may also be utilized within the context of the present invention include Thalidomide, (Celgene, Warren, N.J.); Angiostatic steroid; AGM-1470 (H. Brem and J. Folkman J Pediatr. Surg. 28:445-51 (1993)); an integrin alpha v beta 3 antagonist (C. Storgard et al., J Clin. Invest. 103:47-54 (1999)); carboxynaminolmidazole; Carboxyamidotriazole (CAI) (National Cancer Institute, Bethesda, Md.); Conbretastatin A-4 (CA4P) (OXiGENE, Boston, Mass.); Squalamine (Magainin Pharmaceuticals, Plymouth Meeting, Pa.); TNP-470, (Tap Pharmaceuticals, Deerfield, Ill.); ZD-0101 AstraZeneca (London, UK); APRA (CT2584); Benefin, Byrostatin-1 (SC339555); CGP-41251 (PKC 412); CM101; Dexrazoxane (ICRF187); DMXAA; Endostatin; Flavopridiol; Genestein; GTE; ImmTher; Iressa (ZD1839); Octreotide (Somatostatin); Panretin; Penacillamine; Photopoint; PI-88; Prinomastat (AG-3340) Purlytin; Suradista (FCE26644); Tamoxifen (Nolvadex); Tazarotene; Tetrathiomolybdate; Xeloda (Capecitabine); and 5-Fluorouracil.

[1067] Anti-angiogenic agents that may be administed in combination with the compounds of the invention may work through a variety of mechanisms including, but not limited to, inhibiting proteolysis of the extracellular matrix, blocking the function of endothelial cell-extracellular matrix adhesion molecules, by antagonizing the function of angiogenesis inducers such as growth factors, and inhibiting integrin receptors expressed on proliferating endothelial cells. Examples of anti-angiogenic inhibitors that interfere with extracellular matrix proteolysis and which may be administered in combination with the compositons of the invention include, but are not imited to, AG-3340 (Agouron, La Jolla, Calif.), BAY-12-9566 (Bayer, West Haven, Conn.), BMS-275291 (Bristol Myers Squibb, Princeton, N.J.), CGS-27032A (Novartis, East Hanover, N.J.), Marimastat (British Biotech, Oxford, UK), and Metastat (Aetema, St-Foy, Quebec). Examples of anti-angiogenic inhibitors that act by blocking the function of endothelial cell-extracellular matrix adhesion molecules and which may be administered in combination with the compositons of the invention include, but are not Imited to, EMD-121974 (Merck KcgaA Darmstadt, Germany) and Vitaxin (Ixsys, La Jolla, Calif./Medimmune, Gaithersburg, Md.). Examples of anti-angiogenic agents that act by directly antagonizing or inhibiting angiogenesis inducers and which may be administered in combination with the compositons of the invention include, but are not Imited to, Angiozyme (Ribozyme, Boulder, Colo.), Anti-VEGF antibody (Genentech, S. San Francisco, Calif.), PTK-787/ZK-225846 (Novartis, Basel, Switzerland), SU-101 (Sugen, S. San Francisco, Calif.), SU-5416 (Sugen/ Pharmacia Upjohn, Bridgewater, N.J.), and SU-6668 (Sugen). Other anti-angiogenic agents act to indirectly inhibit angiogenesis. Examples of indirect inhibitors of angiogenesis which may be administered in combination with the compositons of the invention include, but are not limited to, IM-862 (Cytran, Kirkland, Wash.), Interferon-alpha, IL-12 (Roche, Nutley, N.J.), and Pentosan polysulfate (Georgetown University, Washington, D.C.).

[1068] In particular embodiments, the use of compositions of the invention in combination with anti-angiogenic agents is contemplated for the treatment, prevention, and/or amelioration of an autoimmune disease, such as for example, an autoimmune disease described herein.

[1069] In a particular embodiment, the use of compositions of the invention in combination with anti-angiogenic agents is contemplated for the treatment, prevention, and/or amelioration of arthritis. In a more particular embodiment, the use of compositions of the invention in combination with anti-angiogenic agents is contemplated for the treatment, prevention, and/or amelioration of rheumatoid arthritis.

[1070] In another embodiment, the polynucleotides encoding a polypeptide of the present invention are administered in combination with an angiogenic protein, or polynucleotides encoding an angiogenic protein. Examples of angiogenic proteins that may be administered with the compositions of the invention include, but are not limited to, acidic and basic fibroblast growth factors, VEGF-1, VEGF-2, VEGF-3, epidermal growth factor alpha and beta, platelet-derived endothelial cell growth factor, platelet-derived growth factor, tumor necrosis factor alpha, hepatocyte growth factor, insulin like growth factor, colony stimulating factor, macrophage colony stimulating factor, granulocyte/macrophage colony stimulating factor, and nitric oxide synthase.

[1071] In another embodiment, compostions of the invention are administered in combination with a chemotherapeutic agent. Chemotherapeutic agents that may be administered with the compositions of the invention include, but are not limited to, antibiotic derivatives (e.g., doxorubicin, bleomycin, daunorubicin, and dactinomycin); antiestrogens (e.g., tamoxifen); antimetabolites (e.g., fluorouracil, 5-FU, methotrexate, floxuridine, interferon alpha-2b, glutamic acid, plicamycin, mercaptopurine, and 6-thioguanine); cytotoxic agents (e.g., carmustine, BCNU, lomustine, CCNU, cytosine arabinoside, cyclophosphamide, estramustine, hydroxyurea, procarbazine, mitomycin, busulfan, cis-platin, and vincristine sulfate); hormones (e.g., medroxyprogesterone, estramustine phosphate sodium, ethinyl estradiol, estradiol, megestrol acetate, methyltestosterone, diethylstilbestrol diphosphate, chlorotrianisene, and testolactone); nitrogen mustard derivatives (e.g., mephalen, chorambucil, mechlorethamine (nitrogen mustard) and thiotepa); steroids and combinations (e.g., bethamethasone sodium phosphate); and others (e.g., dicarbazine, asparaginase, mitotane, vincristine sulfate, vinblastine sulfate, and etoposide).

[1072] In a specific embodiment, Therapeutics of the invention are administered in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) or any combination of the components of CHOP. In another embodiment, Therapeutics of the invention are administered in combination with Rituximab. In a further embodiment, Therapeutics of the invention are administered with Rituxmab and CHOP, or Rituxmab and any combination of the components of CHOP.

[1073] In an additional embodiment, the Therapeutics of the invention are administered in combination with cytokines. Cytokines that may be administered with the Therapeutics of the invention include, but are not limited to, IL2, IL3, IL4, IL5, IL6, IL7, IL10, IL12, IL13, IL15, anti-CD40, CD40L, IFN-gamma and TNF-alpha. In another embodiment, Therapeutics of the invention may be administered with any interleukin, including, but not limited to, IL-1 alpha, IL-1 beta, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, IL-20, and IL-21.

[1074] In an additional embodiment, the Therapeutics of the invention are administered in combination with angiogenic proteins. Angiogenic proteins that may be administered with the Therapeutics of the invention include, but are not limited to, Glioma Derived Growth Factor (GDGF), as disclosed in European Patent Number EP-399816; Platelet Derived Growth Factor-A (PDGF-A), as disclosed in European Patent Number EP-682110; Platelet Derived Growth Factor-B (PDGF-B), as disclosed in European Patent Number EP-282317; Placental Growth Factor (PlGF), as disclosed in International Publication Number WO 92/06194; Placental Growth Factor-2 (PIGF-2), as disclosed in Hauser et al., Gorwth Factors, 4:259-268 (1993); Vascular Endothelial Growth Factor (VEGF), as disclosed in International Publication Number WO 90/13649; Vascular Endothelial Growth Factor-A (VEGF-A), as disclosed in European Patent Number EP-506477; Vascular Endothelial Growth Factor-2 (VEGF-2), as disclosed in International Publication Number WO 96/39515; Vascular Endothelial Growth Factor B (VEGF-3); Vascular Endothelial Growth Factor B-186 (VEGF-B 186), as disclosed in International Publication Number WO 96/26736; Vascular Endothelial Growth Factor-D (VEGF-D), as disclosed in International Publication Number WO 98/02543; Vascular Endothelial Growth Factor-D (VEGF-D), as disclosed in International Publication Number WO 98/07832; and Vascular Endothelial Growth Factor-E (VEGF-E), as disclosed in German Patent Number DE19639601. The above mentioned references are herein incorporated by reference in their entireties.

[1075] In an additional embodiment, the Therapeutics of the invention are administered in combination with hematopoietic growth factors. Hematopoietic growth factors that may be administered with the Therapeutics of the invention include, but are not limited to, LEUKINE™ (SARGRAMOSTIM™) and NEUPOGEN™ (FILGRASTIM™).

[1076] In an additional embodiment, the Therapeutics of the invention are administered in combination with Fibroblast Growth Factors. Fibroblast Growth Factors that may be administered with the Therapeutics of the invention include, but are not limited to, FGF-1, FGF-2, FGF-3, FGF-4, FGF-5, FGF-6, FGF-7, FGF-8, FGF-9, FGF-10, FGF-11, FGF-12, FGF-13, FGF-14, and FGF-15.

[1077] In additional embodiments, the Therapeutics of the invention are administered in combination with other therapeutic or prophylactic regimens, such as, for example, radiation therapy.

Example 14 Method of Treating Decreased Levels of the Polypeptide

[1078] The present invention relates to a method for treating an individual in need of an increased level of a polypeptide of the invention in the body comprising administering to such an individual a composition comprising a therapeutically effective amount of an agonist of the invention (including polypeptides of the invention). Moreover, it will be appreciated that conditions caused by a decrease in the standard or normal expression level of a polypeptide of the present invention in an individual can be treated by administering the agonist or antagonist of the present invention. Thus, the invention also provides a method of treatment of an individual in need of an increased level of the polypeptide comprising administering to such an individual a Therapeutic comprising an amount of the agonist or antagonist to increase the activity level of the polypeptide in such an individual.

[1079] For example, a patient with decreased levels of a polypeptide receives a daily dose 0.1-100 ug/kg of the agonist or antagonist for six consecutive days. The exact details of the dosing scheme, based on administration and formulation, are provided in Example 13.

Example 15 Method of Treating Increased Levels of the Polypeptide

[1080] The present invention also relates to a method of treating an individual in need of a decreased level of a polypeptide of the invention in the body comprising administering to such an individual a composition comprising a therapeutically effective amount of an antagonist of the invention (including polypeptides and antibodies of the invention).

[1081] In one example, antisense technology is used to inhibit production of a polypeptide of the present invention. This technology is one example of a method of decreasing levels of a polypeptide, due to a variety of etiologies, such as cancer.

[1082] For example, a patient diagnosed with abnormally increased levels of a polypeptide is administered intravenously antisense polynucleotides at 0.5, 1.0, 1.5, 2.0 and 3.0 mg/kg day for 21 days. This treatment is repeated after a 7-day rest period if the treatment was well tolerated. The formulation of the antisense polynucleotide is provided in Example 13.

Example 16 Method of Treatment Using Gene Therapy-Ex Vivo

[1083] One method of gene therapy transplants fibroblasts, which are capable of expressing a polypeptide, onto a patient. Generally, fibroblasts are obtained from a subject by skin biopsy. The resulting tissue is placed in tissue-culture medium and separated into small pieces. Small chunks of the tissue are placed on a wet surface of a tissue culture flask, approximately ten pieces are placed in each flask. The flask is turned upside down, closed tight and left at room temperature over night. After 24 hours at room temperature, the flask is inverted and the chunks of tissue remain fixed to the bottom of the flask and fresh media (e.g., Ham's F12 media, with 10% FBS, penicillin and streptomycin) is added. The flasks are then incubated at 37 degree C. for approximately one week.

[1084] At this time, fresh media is added and subsequently changed every several days. After an additional two weeks in culture, a monolayer of fibroblasts emerge. The monolayer is trypsinized and scaled into larger flasks.

[1085] pMV-7 (Kirschmeier, P. T. et al., DNA, 7:219-25 (1988)), flanked by the long terminal repeats of the Moloney murine sarcoma virus, is digested with EcoRI and HindIII and subsequently treated with calf intestinal phosphatase. The linear vector is fractionated on agarose gel and purified, using glass beads.

[1086] The cDNA encoding a polypeptide of the present invention can be amplified using PCR primers which correspond to the 5′ and 3′ end sequences respectively as set forth in Example 1 using primers and having appropriate restriction sites and initiation/stop codons, if necessary. Preferably, the 5′ primer contains an EcoRI site and the 3′ primer includes a HindIII site. Equal quantities of the Moloney murine sarcoma virus linear backbone and the amplified EcoRI and HindIII fragment are added together, in the presence of T4 DNA ligase. The resulting mixture is maintained under conditions appropriate for ligation of the two fragments. The ligation mixture is then used to transform bacteria HB 101, which are then plated onto agar containing kanamycin for the purpose of confirming that the vector has the gene of interest properly inserted.

[1087] The amphotropic pA317 or GP+am12 packaging cells are grown in tissue culture to confluent density in Dulbecco's Modified Eagles Medium (DMEM) with 10% calf serum (CS), penicillin and streptomycin. The MSV vector containing the gene is then added to the media and the packaging cells transduced with the vector. The packaging cells now produce infectious viral particles containing the gene (the packaging cells are now referred to as producer cells).

[1088] Fresh media is added to the transduced producer cells, and subsequently, the media is harvested from a 10 cm plate of confluent producer cells. The spent media, containing the infectious viral particles, is filtered through a millipore filter to remove detached producer cells and this media is then used to infect fibroblast cells. Media is removed from a sub-confluent plate of fibroblasts and quickly replaced with the media from the producer cells. This media is removed and replaced with fresh media. If the titer of virus is high, then virtually all fibroblasts will be infected and no selection is required. If the titer is very low, then it is necessary to use a retroviral vector that has a selectable marker, such as neo or his. Once the fibroblasts have been efficiently infected, the fibroblasts are analyzed to determine whether protein is produced.

[1089] The engineered fibroblasts are then transplanted onto the host, either alone or after having been grown to confluence on cytodex 3 microcarrier beads.

Example 17 Gene Therapy Using Endogenous Genes Corresponding To Polynucleotides of the Invention

[1090] Another method of gene therapy according to the present invention involves operably associating the endogenous polynucleotide sequence of the invention with a promoter via homologous recombination as described, for example, in U.S. Pat. No. 5,641,670, issued Jun. 24, 1997; International Publication NO: WO 96/29411, published Sep. 26, 1996; International Publication NO: WO 94/12650, published Aug. 4, 1994; Koller et al., Proc. Natl. Acad. Sci. USA, 86:8932-8935 (1989); and Zijlstra et al., Nature, 342:435-438 (1989). This method involves the activation of a gene which is present in the target cells, but which is not expressed in the cells, or is expressed at a lower level than desired.

[1091] Polynucleotide constructs are made which contain a promoter and targeting sequences, which are homologous to the 5′ non-coding sequence of endogenous polynucleotide sequence, flanking the promoter. The targeting sequence will be sufficiently near the 5′ end of the polynucleotide sequence so the promoter will be operably linked to the endogenous sequence upon homologous recombination. The promoter and the targeting sequences can be amplified using PCR. Preferably, the amplified promoter contains distinct restriction enzyme sites on the 5′ and 3′ ends. Preferably, the 3′ end of the first targeting sequence contains the same restriction enzyme site as the 5′ end of the amplified promoter and the 5′ end of the second targeting sequence contains the same restriction site as the 3′ end of the amplified promoter.

[1092] The amplified promoter and the amplified targeting sequences are digested with the appropriate restriction enzymes and subsequently treated with calf intestinal phosphatase. The digested promoter and digested targeting sequences are added together in the presence of T4 DNA ligase. The resulting mixture is maintained under conditions appropriate for ligation of the two fragments. The construct is size fractionated on an agarose gel, then purified by phenol extraction and ethanol precipitation.

[1093] In this Example, the polynucleotide constructs are administered as naked polynucleotides via electroporation. However, the polynucleotide constructs may also be administered with transfection-facilitating agents, such as liposomes, viral sequences, viral particles, precipitating agents, etc. Such methods of delivery are known in the art.

[1094] Once the cells are transfected, homologous recombination will take place which results in the promoter being operably linked to the endogenous polynucleotide sequence. This results in the expression of polynucleotide corresponding to the polynucleotide in the cell. Expression may be detected by immunological staining, or any other method known in the art.

[1095] Fibroblasts are obtained from a subject by skin biopsy. The resulting tissue is placed in DMEM+10% fetal calf serum. Exponentially growing or early stationary phase fibroblasts are trypsinized and rinsed from the plastic surface with nutrient medium. An aliquot of the cell suspension is removed for counting, and the remaining cells are subjected to centrifugation. The supernatant is aspirated and the pellet is resuspended in 5 ml of electroporation buffer (20 mM HEPES pH 7.3, 137 mM NaCl, 5 mM KCl, 0.7 mM Na₂ HPO₄, 6 mM dextrose). The cells are recentrifuged, the supernatant aspirated, and the cells resuspended in electroporation buffer containing 1 mg/ml acetylated bovine serum albumin. The final cell suspension contains approximately 3×10⁶ cells/ml. Electroporation should be performed immediately following resuspension.

[1096] Plasmid DNA is prepared according to standard techniques. For example, to construct a plasmid for targeting to the locus corresponding to the polynucleotide of the invention, plasmid pUC18 (MBI Fermentas, Amherst, N.Y.) is digested with HindIII. The CMV promoter is amplified by PCR with an XbaI site on the 5′ end and a BamHI site on the 3′ end. Two non-coding sequences are amplified via PCR: one non-coding sequence (fragment 1) is amplified with a HindIII site at the 5′ end and an Xba site at the 3′end; the other non-coding sequence (fragment 2) is amplified with a BamHI site at the 5′end and a HindIII site at the 3′end. The CMV promoter and the fragments (1 and 2) are digested with the appropriate enzymes (CMV promoter—XbaI and BamHI; fragment 1—XbaI; fragment 2—BamHI) and ligated together. The resulting ligation product is digested with HindIII, and ligated with the HindIII-digested pUC 18 plasmid.

[1097] Plasmid DNA is added to a sterile cuvette with a 0.4 cm electrode gap (Bio-Rad). The final DNA concentration is generally at least 120 μg/ml. 0.5 ml of the cell suspension (containing approximately 1.5×10⁶ cells) is then added to the cuvette, and the cell suspension and DNA solutions are gently mixed. Electroporation is performed with a Gene-Pulser apparatus (Bio-Rad). Capacitance and voltage are set at 960 μF and 250-300 V, respectively. As voltage increases, cell survival decreases, but the percentage of surviving cells that stably incorporate the introduced DNA into their genome increases dramatically. Given these parameters, a pulse time of approximately 14-20 mSec should be observed.

[1098] Electroporated cells are maintained at room temperature for approximately 5 min, and the contents of the cuvette are then gently removed with a sterile transfer pipette. The cells are added directly to 10 ml of prewarmed nutrient media (DMEM with 15% calf serum) in a 10 cm dish and incubated at 37 degree C. The following day, the media is aspirated and replaced with 10 ml of fresh media and incubated for a further 16-24 hours.

[1099] The engineered fibroblasts are then injected into the host, either alone or after having been grown to confluence on cytodex 3 microcarrier beads. The fibroblasts now produce the protein product. The fibroblasts can then be introduced into a patient as described above.

Example 18 Method of Treatment Using Gene Therapy—in vivo

[1100] Another aspect of the present invention is using in vivo gene therapy methods to treat disorders, diseases and conditions. The gene therapy method relates to the introduction of naked nucleic acid (DNA, RNA, and antisense DNA or RNA) sequences into an animal to increase or decrease the expression of the polypeptide. The polynucleotide of the present invention may be operatively linked to (i.e., associated with) a promoter or any other genetic elements necessary for the expression of the polypeptide by the target tissue. Such gene therapy and delivery techniques and methods are known in the art, see, for example, WO90/11092, WO98/11779; U.S. Pat. Nos. 5,693,622, 5,705,151, 5,580,859; Tabata et al., Cardiovasc. Res. 35(3):470-479 (1997); Chao et al., Pharmacol. Res. 35(6):517-522 (1997); Wolff, Neuromuscul. Disord. 7(5):314-318 (1997); Schwartz et al., Gene Ther. 3(5):405-411 (1996); Tsurumi et al., Circulation 94(12):3281-3290 (1996) (incorporated herein by reference).

[1101] The polynucleotide constructs may be delivered by any method that delivers injectable materials to the cells of an animal, such as, injection into the interstitial space of tissues (heart, muscle, skin, lung, liver, intestine and the like). The polynucleotide constructs can be delivered in a pharmaceutically acceptable liquid or aqueous carrier.

[1102] The term “naked” polynucleotide, DNA or RNA, refers to sequences that are free from any delivery vehicle that acts to assist, promote, or facilitate entry into the cell, including viral sequences, viral particles, liposome formulations, lipofectin or precipitating agents and the like. However, the polynucleotides of the present invention may also be delivered in liposome formulations (such as those taught in Felgner P. L. et al. (1995) Ann. NY Acad. Sci. 772:126-139 and Abdallah B. et al. (1995) Biol. Cell 85(1):1-7) which can be prepared by methods well known to those skilled in the art.

[1103] The polynucleotide vector constructs used in the gene therapy method are preferably constructs that will not integrate into the host genome nor will they contain sequences that allow for replication. Any strong promoter known to those skilled in the art can be used for driving the expression of DNA. Unlike other gene therapy techniques, one major advantage of introducing naked nucleic acid sequences into target cells is the transitory nature of the polynucleotide synthesis in the cells. Studies have shown that non-replicating DNA sequences can be introduced into cells to provide production of the desired polypeptide for periods of up to six months.

[1104] The polynucleotide construct can be delivered to the interstitial space of tissues within an animal, including muscle, skin, brain, lung, liver, spleen, bone marrow, thymus, heart, lymph, blood, bone, cartilage, pancreas, kidney, gall bladder, stomach, intestine, testis, ovary, uterus, rectum, nervous system, eye, gland, and connective tissue. Interstitial space of the tissues comprises the intercellular fluid, mucopolysaccharide matrix among the reticular fibers of organ tissues, elastic fibers in the walls of vessels or chambers, collagen fibers of fibrous tissues, or that same matrix within connective tissue ensheathing muscle cells or in the lacunae of bone. It is similarly the space occupied by the plasma of the circulation and the lymph fluid of the lymphatic channels. Delivery to the interstitial space of muscle tissue is preferred for the reasons discussed below. They may be conveniently delivered by injection into the tissues comprising these cells. They are preferably delivered to and expressed in persistent, non-dividing cells which are differentiated, although delivery and expression may be achieved in non-differentiated or less completely differentiated cells, such as, for example, stem cells of blood or skin fibroblasts. In vivo muscle cells are particularly competent in their ability to take up and express polynucleotides.

[1105] For the naked polynucleotide injection, an effective dosage amount of DNA or RNA will be in the range of from about 0.05 g/kg body weight to about 50 mg/kg body weight. Preferably the dosage will be from about 0.005 mg/kg to about 20 mg/kg and more preferably from about 0.05 mg/kg to about 5 mg/kg. Of course, as the artisan of ordinary skill will appreciate, this dosage will vary according to the tissue site of injection. The appropriate and effective dosage of nucleic acid sequence can readily be determined by those of ordinary skill in the art and may depend on the condition being treated and the route of administration. The preferred route of administration is by the parenteral route of injection into the interstitial space of tissues. However, other parenteral routes may also be used, such as, inhalation of an aerosol formulation particularly for delivery to lungs or bronchial tissues, throat or mucous membranes of the nose. In addition, naked polynucleotide constructs can be delivered to arteries during angioplasty by the catheter used in the procedure.

[1106] The dose response effects of injected polynucleotide in muscle in vivo is determined as follows. Suitable template DNA for production of mRNA coding for polypeptide of the present invention is prepared in accordance with a standard recombinant DNA methodology. The template DNA, which may be either circular or linear, is either used as naked DNA or complexed with liposomes. The quadriceps muscles of mice are then injected with various amounts of the template DNA.

[1107] Five to six week old female and male Balb/C mice are anesthetized by intraperitoneal injection with 0.3 ml of 2.5% Avertin. A 1.5 cm incision is made on the anterior thigh, and the quadriceps muscle is directly visualized. The template DNA is injected in 0.1 ml of carrier in a 1 cc syringe through a 27 gauge needle over one minute, approximately 0.5 cm from the distal insertion site of the muscle into the knee and about 0.2 cm deep. A suture is placed over the injection site for future localization, and the skin is closed with stainless steel clips.

[1108] After an appropriate incubation time (e.g., 7 days) muscle extracts are prepared by excising the entire quadriceps. Every fifth 15 um cross-section of the individual quadriceps muscles is histochemically stained for protein expression. A time course for protein expression may be done in a similar fashion except that quadriceps from different mice are harvested at different times. Persistence of DNA in muscle following injection may be determined by Southern blot analysis after preparing total cellular DNA and HIRT supernatants from injected and control mice. The results of the above experimentation in mice can be used to extrapolate proper dosages and other treatment parameters in humans and other animals using naked DNA.

Example 19 Transgenic Animals

[1109] The polypeptides of the invention can also be expressed in transgenic animals. Animals of any species, including, but not limited to, mice, rats, rabbits, hamsters, guinea pigs, pigs, micro-pigs, goats, sheep, cows and non-human primates, e.g., baboons, monkeys, and chimpanzees may be used to generate transgenic animals. In a specific embodiment, techniques described herein or otherwise known in the art, are used to express polypeptides of the invention in humans, as part of a gene therapy protocol.

[1110] Any technique known in the art may be used to introduce the transgene (i.e., polynucleotides of the invention) into animals to produce the founder lines of transgenic animals. Such techniques include, but are not limited to, pronuclear microinjection (Paterson et al., Appl. Microbiol. Biotechnol. 40:691-698 (1994); Carver et al., Biotechnology (NY) 11:1263-1270 (1993); Wright et al., Biotechnology (NY) 9:830-834 (1991); and Hoppe et al., U.S. Pat. No. 4,873,191 (1989)); retrovirus mediated gene transfer into germ lines (Van der Putten et al., Proc. Natl. Acad. Sci., USA 82:6148-6152 (1985)), blastocysts or embryos; gene targeting in embryonic stem cells (Thompson et al., Cell 56:313-321 (1989)); electroporation of cells or embryos (Lo, 1983, Mol Cell. Biol. 3:1803-1814 (1983)); introduction of the polynucleotides of the invention using a gene gun (see, e.g., Ulmer et al., Science 259:1745 (1993); introducing nucleic acid constructs into embryonic pleuripotent stem cells and transferring the stem cells back into the blastocyst; and sperm-mediated gene transfer (Lavitrano et al., Cell 57:717-723 (1989); etc. For a review of such techniques, see Gordon, “Transgenic Animals,” Intl. Rev. Cytol. 115:171-229 (1989), which is incorporated by reference herein in its entirety.

[1111] Any technique known in the art may be used to produce transgenic clones containing polynucleotides of the invention, for example, nuclear transfer into enucleated oocytes of nuclei from cultured embryonic, fetal, or adult cells induced to quiescence (Campell et al., Nature 380:64-66 (1996); Wilmut et al., Nature 385:810-813 (1997)).

[1112] The present invention provides for transgenic animals that carry the transgene in all their cells, as well as animals which carry the transgene in some, but not all their cells, i.e., mosaic animals or chimeric. The transgene may be integrated as a single transgene or as multiple copies such as in concatamers, e.g., head-to-head tandems or head-to-tail tandems. The transgene may also be selectively introduced into and activated in a particular cell type by following, for example, the teaching of Lasko et al. (Lasko et al., Proc. Natl. Acad. Sci. USA 89:6232-6236 (1992)). The regulatory sequences required for such a cell-type specific activation will depend upon the particular cell type of interest, and will be apparent to those of skill in the art. When it is desired that the polynucleotide transgene be integrated into the chromosomal site of the endogenous gene, gene targeting is preferred. Briefly, when such a technique is to be utilized, vectors containing some nucleotide sequences homologous to the endogenous gene are designed for the purpose of integrating, via homologous recombination with chromosomal sequences, into and disrupting the function of the nucleotide sequence of the endogenous gene. The transgene may also be selectively introduced into a particular cell type, thus inactivating the endogenous gene in only that cell type, by following, for example, the teaching of Gu et al. (Gu et al., Science 265:103-106 (1994)). The regulatory sequences required for such a cell-type specific inactivation will depend upon the particular cell type of interest, and will be apparent to those of skill in the art.

[1113] Once transgenic animals have been generated, the expression of the recombinant gene may be assayed utilizing standard techniques. Initial screening may be accomplished by Southern blot analysis or PCR techniques to analyze animal tissues to verify that integration of the transgene has taken place. The level of mRNA expression of the transgene in the tissues of the transgenic animals may also be assessed using techniques which include, but are not limited to, Northern blot analysis of tissue samples obtained from the animal, in situ hybridization analysis, and reverse transcriptase-PCR (rt-PCR). Samples of transgenic gene-expressing tissue may also be evaluated immunocytochemically or immunohistochemically using antibodies specific for the transgene product.

[1114] Once the founder animals are produced, they may be bred, inbred, outbred, or crossbred to produce colonies of the particular animal. Examples of such breeding strategies include, but are not limited to: outbreeding of founder animals with more than one integration site in order to establish separate lines; inbreeding of separate lines in order to produce compound transgenics that express the transgene at higher levels because of the effects of additive expression of each transgene; crossing of heterozygous transgenic animals to produce animals homozygous for a given integration site in order to both augment expression and eliminate the need for screening of animals by DNA analysis; crossing of separate homozygous lines to produce compound heterozygous or homozygous lines; and breeding to place the transgene on a distinct background that is appropriate for an experimental model of interest.

[1115] Transgenic animals of the invention have uses which include, but are not limited to, animal model systems useful in elaborating the biological function of polypeptides of the present invention, studying conditions and/or disorders associated with aberrant expression, and in screening for compounds effective in ameliorating such conditions and/or disorders.

Example 20 Knock-Out Animals

[1116] Endogenous gene expression can also be reduced by inactivating or “knocking out” the gene and/or its promoter using targeted homologous recombination. (See e.g., Smithies et al., Nature 317:230-234 (1985); Thomas & Capecchi, Cell 51:503-512 (1987); Thompson et al., Cell 5:313-321 (1989); each of which is incorporated by reference herein in its entirety.) For example, a mutant, non-functional polynucleotide of the invention (or a completely unrelated DNA sequence) flanked by DNA homologous to the endogenous polynucleotide sequence (either the coding regions or regulatory regions of the gene) can be used, with or without a selectable marker and/or a negative selectable marker, to transfect cells that express polypeptides of the invention in vivo. In another embodiment, techniques known in the art are used to generate knockouts in cells that contain, but do not express the gene of interest. Insertion of the DNA construct, via targeted homologous recombination, results in inactivation of the targeted gene. Such approaches are particularly suited in research and agricultural fields where modifications to embryonic stem cells can be used to generate animal offspring with an inactive targeted gene (e.g., see Thomas & Capecchi 1987 and Thompson 1989, supra). However this approach can be routinely adapted for use in humans provided the recombinant DNA constructs are directly administered or targeted to the required site in vivo using appropriate viral vectors that will be apparent to those of skill in the art.

[1117] In further embodiments of the invention, cells that are genetically engineered to express the polypeptides of the invention, or alternatively, that are genetically engineered not to express the polypeptides of the invention (e.g., knockouts) are administered to a patient in vivo. Such cells may be obtained from the patient (i.e., animal, including human) or an MHC compatible donor and can include, but are not limited to fibroblasts, bone marrow cells, blood cells (e.g., lymphocytes), adipocytes, muscle cells, endothelial cells etc. The cells are genetically engineered in vitro using recombinant DNA techniques to introduce the coding sequence of polypeptides of the invention into the cells, or alternatively, to disrupt the coding sequence and/or endogenous regulatory sequence associated with the polypeptides of the invention, e.g., by transduction (using viral vectors, and preferably vectors that integrate the transgene into the cell genome) or transfection procedures, including, but not limited to, the use of plasmids, cosmids, YACs, naked DNA, electroporation, liposomes, etc. The coding sequence of the polypeptides of the invention can be placed under the control of a strong constitutive or inducible promoter or promoter/enhancer to achieve expression, and preferably secretion, of the polypeptides of the invention. The engineered cells which express and preferably secrete the polypeptides of the invention can be introduced into the patient systemically, e.g., in the circulation, or intraperitoneally.

[1118] Alternatively, the cells can be incorporated into a matrix and implanted in the body, e.g., genetically engineered fibroblasts can be implanted as part of a skin graft; genetically engineered endothelial cells can be implanted as part of a lymphatic or vascular graft. (See, for example, Anderson et al. U.S. Pat. No. 5,399,349; and Mulligan & Wilson, U.S. Pat. No. 5,460,959 each of which is incorporated by reference herein in its entirety).

[1119] When the cells to be administered are non-autologous or non-MHC compatible cells, they can be administered using well known techniques which prevent the development of a host immune response against the introduced cells. For example, the cells may be introduced in an encapsulated form which, while allowing for an exchange of components with the immediate extracellular environment, does not allow the introduced cells to be recognized by the host immune system.

[1120] Transgenic and “knock-out” animals of the invention have uses which include, but are not limited to, animal model systems useful in elaborating the biological function of polypeptides of the present invention, studying conditions and/or disorders associated with aberrant expression, and in screening for compounds effective in ameliorating such conditions and/or disorders.

Example 21 Assays Detecting Stimulation or Inhibition of B cell Proliferation and Differentiation

[1121] Generation of functional humoral immune responses requires both soluble and cognate signaling between B-lineage cells and their microenvironment. Signals may impart a positive stimulus that allows a B-lineage cell to continue its programmed development, or a negative stimulus that instructs the cell to arrest its current developmental pathway. To date, numerous stimulatory and inhibitory signals have been found to influence B cell responsiveness including IL-2, IL-4, IL-5, IL-6, IL-7, IL10, IL-13, IL-14 and IL-15. Interestingly, these signals are by themselves weak effectors but can, in combination with various co-stimulatory proteins, induce activation, proliferation, differentiation, homing, tolerance and death among B cell populations.

[1122] One of the best studied classes of B-cell co-stimulatory proteins is the TNF-superfamily. Within this family CD40, CD27, and CD30 along with their respective ligands CD154, CD70, and CD153 have been found to regulate a variety of immune responses. Assays which allow for the detection and/or observation of the proliferation and differentiation of these B-cell populations and their precursors are valuable tools in determining the effects various proteins may have on these B-cell populations in terms of proliferation and differentiation. Listed below are two assays designed to allow for the detection of the differentiation, proliferation, or inhibition of B-cell populations and their precursors.

[1123] In vitro Assay—Agonists or antagonists of the invention can be assessed for its ability to induce activation, proliferation, differentiation or inhibition and/or death in B-cell populations and their precursors. The activity of the agonists or antagonists of the invention on purified human tonsillar B cells, measured qualitatively over the dose range from 0.1 to 10,000 ng/mL, is assessed in a standard B-lymphocyte co-stimulation assay in which purified tonsillar B cells are cultured in the presence of either formalin-fixed Staphylococcus aureus Cowan I (SAC) or immobilized anti-human IgM antibody as the priming agent. Second signals such as IL-2 and IL-15 synergize with SAC and IgM crosslinking to elicit B cell proliferation as measured by tritiated-thymidine incorporation. Novel synergizing agents can be readily identified using this assay. The assay involves isolating human tonsillar B cells by magnetic bead (MACS) depletion of CD3-positive cells. The resulting cell population is greater than 95% B cells as assessed by expression of CD45R(B220).

[1124] Various dilutions of each sample are placed into individual wells of a 96-well plate to which are added 10⁵ B-cells suspended in culture medium (RPMI 1640 containing 10% FBS, 5×10⁻⁵M 2ME, 100 U/ml penicillin, 10 ug/ml streptomycin, and 10⁻⁵ dilution of SAC) in a total volume of 150 ul. Proliferation or inhibition is quantitated by a 20 h pulse (1 uCi/well) with 3H-thymidine (6.7 Ci/mM) beginning 72 h post factor addition. The positive and negative controls are IL2 and medium respectively.

[1125] In Vivo Assay—BALB/c mice are injected (i.p.) twice per day with buffer only, or 2 mg/Kg of agonists or antagonists of the invention, or truncated forms thereof. Mice receive this treatment for 4 consecutive days, at which time they are sacrificed and various tissues and serum collected for analyses. Comparison of H&E sections from normal spleens and spleens treated with agonists or antagonists of the invention identify the results of the activity of the agonists or antagonists on spleen cells, such as the diffusion of peri-arterial lymphatic sheaths, and/or significant increases in the nucleated cellularity of the red pulp regions, which may indicate the activation of the differentiation and proliferation of B-cell populations.

[1126] Immunohistochemical studies using a B cell marker, anti-CD45R(B220), are used to determine whether any physiological changes to splenic cells, such as splenic disorganization, are due to increased B-cell representation within loosely defined B-cell zones that infiltrate established T-cell regions.

[1127] Flow cytometric analyses of the spleens from mice treated with agonist or antagonist is used to indicate whether the agonists or antagonists specifically increases the proportion of ThB+, CD45R(B220)dull B cells over that which is observed in control mice.

[1128] Likewise, a predicted consequence of increased mature B-cell representation in vivo is a relative increase in serum Ig titers. Accordingly, serum IgM and IgA levels are compared between buffer and agonists or antagonists-treated mice.

[1129] The studies described in this example tested activity of agonists or antagonists of the invention. However, one skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides or polypeptides of the invention (e.g., gene therapy).

Example 22 T Cell Proliferation Assay

[1130] A CD3-induced proliferation assay is performed on PBMCs and is measured by the uptake of ³H-thymidine. The assay is performed as follows. Ninety-six well plates are coated with 100 μl/well of mAb to CD3 (HIT3a, Pharmingen) or isotype-matched control mAb (B33.1) overnight at 4 degrees C. (1 μg/ml in 0.05M bicarbonate buffer, pH 9.5), then washed three times with PBS. PBMC are isolated by F/H gradient centrifugation from human peripheral blood and added to quadruplicate wells (5×10⁴/well) of mAb coated plates in RPMI containing 10% FCS and P/S in the presence of varying concentrations of agonists or antagonists of the invention (total volume 200 ul). Relevant protein buffer and medium alone are controls. After 48 hr. culture at 37 degrees C., plates are spun for 2 min. at 1000 rpm and 100 μl of supernatant is removed and stored −20 degrees C. for measurement of IL-2 (or other cytokines) if effect on proliferation is observed. Wells are supplemented with 100 ul of medium containing 0.5 uCi of ³H-thymidine and cultured at 37 degrees C. for 18-24 hr. Wells are harvested and incorporation of ³H-thymidine used as a measure of proliferation. Anti-CD3 alone is the positive control for proliferation. IL-2 (100 U/ml) is also used as a control which enhances proliferation. Control antibody which does not induce proliferation of T cells is used as the negative control for the effects of agonists or antagonists of the invention.

[1131] The studies described in this example tested activity of agonists or antagonists of the invention. However, one skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides or polypeptides of the invention (e.g., gene therapy).

Example 23 Effect of Agonists or Antagonists of the Invention on the Expression of MHC Class II, Costimulatory and Adhesion Molecules and Cell Differentiation of Monocytes and Monocyte-Derived Human Dendritic Cells

[1132] Dendritic cells are generated by the expansion of proliferating precursors found in the peripheral blood: adherent PBMC or elutriated monocytic fractions are cultured for 7-10 days with GM-CSF (50 ng/ml) and IL-4 (20 ng/ml). These dendritic cells have the characteristic phenotype of immature cells (expression of CD1, CD80, CD86, CD40 and MHC class II antigens). Treatment with activating factors, such as TNF-α, causes a rapid change in surface phenotype (increased expression of MHC class I and II, costimulatory and adhesion molecules, downregulation of FCγRII, upregulation of CD83). These changes correlate with increased antigen-presenting capacity and with functional maturation of the dendritic cells.

[1133] FACS analysis of surface antigens is performed as follows. Cells are treated 1-3 days with increasing concentrations of agonist or antagonist of the invention or LPS (positive control), washed with PBS containing 1% BSA and 0.02 mM sodium azide, and then incubated with 1:20 dilution of appropriate FITC- or PE-labeled monoclonal antibodies for 30 minutes at 4 degrees C. After an additional wash, the labeled cells are analyzed by flow cytometry on a FACScan (Becton Dickinson).

[1134] Effect on the production of cytokines. Cytokines generated by dendritic cells, in particular IL-12, are important in the initiation of T-cell dependent immune responses. IL-12 strongly influences the development of Thl helper T-cell immune response, and induces cytotoxic T and NK cell function. An ELISA is used to measure the IL-12 release as follows. Dendritic cells (10⁶/ml) are treated with increasing concentrations of agonists or antagonists of the invention for 24 hours. LPS (100 ng/ml) is added to the cell culture as positive control. Supernatants from the cell cultures are then collected and analyzed for IL-12 content using commercial ELISA kit (e.g., R & D Systems (Minneapolis, Minn.)). The standard protocols provided with the kits are used.

[1135] Effect on the expression of MHC Class II, costimulatory and adhesion molecules. Three major families of cell surface antigens can be identified on monocytes: adhesion molecules, molecules involved in antigen presentation, and Fc receptor. Modulation of the expression of MHC class II antigens and other costimulatory molecules, such as B7 and ICAM-1, may result in changes in the antigen presenting capacity of monocytes and ability to induce T cell activation. Increased expression of Fc receptors may correlate with improved monocyte cytotoxic activity, cytokine release and phagocytosis.

[1136] FACS analysis is used to examine the surface antigens as follows.

[1137] Monocytes are treated 1-5 days with increasing concentrations of agonists or antagonists of the invention or LPS (positive control), washed with PBS containing 1% BSA and 0.02 mM sodium azide, and then incubated with 1:20 dilution of appropriate FITC- or PE-labeled monoclonal antibodies for 30 minutes at 4 degrees C.

[1138] After an additional wash, the labeled cells are analyzed by flow cytometry on a FACScan (Becton Dickinson).

[1139] Monocyte activation and/or increased survival. Assays for molecules that activate (or alternatively, inactivate) monocytes and/or increase monocyte survival (or alternatively, decrease monocyte survival) are known in the art and may routinely be applied to determine whether a molecule of the invention functions as an inhibitor or activator of monocytes. Agonists or antagonists of the invention can be screened using the three assays described below. For each of these assays, Peripheral blood mononuclear cells (PBMC) are purified from single donor leukopacks (American Red Cross, Baltimore, Md.) by centrifugation through a Histopaque gradient (Sigma). Monocytes are isolated from PBMC by counterflow centrifugal elutriation.

[1140] Monocyte Survival Assay. Human peripheral blood monocytes progressively lose viability when cultured in absence of serum or other stimuli. Their death results from internally regulated processes (apoptosis). Addition to the culture of activating factors, such as TNF-alpha dramatically improves cell survival and prevents DNA fragmentation. Propidium iodide (PI) staining is used to measure apoptosis as follows. Monocytes are cultured for 48 hours in polypropylene tubes in serum-free medium (positive control), in the presence of 100 ng/ml TNF-alpha (negative control), and in the presence of varying concentrations of the compound to be tested. Cells are suspended at a concentration of 2×10⁶/ml in PBS containing PI at a final concentration of 5 μg/ml, and then incubated at room temperature for 5 minutes before FACScan analysis. PI uptake has been demonstrated to correlate with DNA fragmentation in this experimental paradigm.

[1141] Effect on cytokine release. An important function of monocytes/macrophages is their regulatory activity on other cellular populations of the immune system through the release of cytokines after stimulation. An ELISA to measure cytokine release is performed as follows. Human monocytes are incubated at a density of 5×10⁵ cells/ml with increasing concentrations of agonists or antagonists of the invention and under the same conditions, but in the absence of agonists or antagonists. For IL-12 production, the cells are primed overnight with IFN (100 U/ml) in the presence of agonist or antagonist of the invention. LPS (10 ng/ml) is then added. Conditioned media are collected after 24h and kept frozen until use. Measurement of TNF-alpha, IL-10, MCP-1 and IL-8 is then performed using a commercially available ELISA kit (e.g., R & D Systems (Minneapolis, Minn.)) and applying the standard protocols provided with the kit.

[1142] Oxidative burst. Purified monocytes are plated in 96-w plate at 2-1×10 ⁵ cell/well. Increasing concentrations of agonists or antagonists of the invention are added to the wells in a total volume of 0.2 ml culture medium (RPMI 1640+10% FCS, glutamine and antibiotics). After 3 days incubation, the plates are centrifuged and the medium is removed from the wells. To the macrophage monolayers, 0.2 ml per well of phenol red solution (140 mM NaCl, 10 mM potassium phosphate buffer pH 7.0, 5.5 mM dextrose, 0.56 mM phenol red and 19 U/ml of HRPO) is added, together with the stimulant (200 nM PMA). The plates are incubated at 37° C. for 2 hours and the reaction is stopped by adding 20 μl 1N NaOH per well. The absorbance is read at 610 nm. To calculate the amount of H₂O₂ produced by the macrophages, a standard curve of a H₂O₂ solution of known molarity is performed for each experiment.

[1143] The studies described in this example tested activity of agonists or antagonists of the invention. However, one skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides or polypeptides of the invention (e.g., gene therapy).

Example 24 Biological Effects of Agonists or Antagonists of the Invention Astrocyte and Neuronal Assays.

[1144] Agonists or antagonists of the invention, expressed in Escherichia coli and purified as described above, can be tested for activity in promoting the survival, neurite outgrowth, or phenotypic differentiation of cortical neuronal cells and for inducing the proliferation of glial fibrillary acidic protein immunopositive cells, astrocytes. The selection of cortical cells for the bioassay is based on the prevalent expression of FGF-1and FGF-2 in cortical structures and on the previously reported enhancement of cortical neuronal survival resulting from FGF-2 treatment. A thymidine incorporation assay, for example, can be used to elucidate an agonist or antagonist of the invention's activity on these cells.

[1145] Moreover, previous reports describing the biological effects of FGF-2 (basic FGF) on cortical or hippocampal neurons in vitro have demonstrated increases in both neuron survival and neurite outgrowth (Walicke et al., “Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.” Proc. Natl. Acad. Sci. USA 83:3012-3016. (1986), assay herein incorporated by reference in its entirety). However, reports from experiments done on PC-12 cells suggest that these two responses are not necessarily synonymous and may depend on not only which FGF is being tested but also on which receptor(s) are expressed on the target cells. Using the primary cortical neuronal culture paradigm, the ability of an agonist or antagonist of the invention to induce neurite outgrowth can be compared to the response achieved with FGF-2 using, for example, a thymidine incorporation assay.

[1146] Fibroblast and Endothelial Cell Assays

[1147] Human lung fibroblasts are obtained from Clonetics (San Diego, Calif.) and maintained in growth media from Clonetics. Dermal microvascular endothelial cells are obtained from Cell Applications (San Diego, Calif.). For proliferation assays, the human lung fibroblasts and dermal microvascular endothelial cells can be cultured at 5,000 cells/well in a 96-well plate for one day in growth medium. The cells are then incubated for one day in 0.1% BSA basal medium. After replacing the medium with fresh 0.1% BSA medium, the cells are incubated with the test proteins for 3 days. Alamar Blue (Alamar Biosciences, Sacramento, Calif.) is added to each well to a final concentration of 10%. The cells are incubated for 4 hr. Cell viability is measured by reading in a CytoFluor fluorescence reader. For the PGE₂ assays, the human lung fibroblasts are cultured at 5,000 cells/well in a 96-well plate for one day. After a medium change to 0.1% BSA basal medium, the cells are incubated with FGF-2 or agonists or antagonists of the invention with or without IL-1α for 24 hours. The supernatants are collected and assayed for PGE₂ by EIA kit (Cayman, Ann Arbor, Mich.). For the IL-6 assays, the human lung fibroblasts are cultured at 5,000 cells/well in a 96-well plate for one day. After a medium change to 0.1% BSA basal medium, the cells are incubated with FGF-2 or with or without agonists or antagonists of the invention IL-1α for 24 hours. The supernatants are collected and assayed for IL-6 by ELISA kit (Endogen, Cambridge, Mass.).

[1148] Human lung fibroblasts are cultured with FGF-2 or agonists or antagonists of the invention for 3 days in basal medium before the addition of Alamar Blue to assess effects on growth of the fibroblasts. FGF-2 should show a stimulation at 10-2500 ng/ml which can be used to compare stimulation with agonists or antagonists of the invention.

[1149] Parkinson Models.

[1150] The loss of motor function in Parkinson's disease is attributed to a deficiency of striatal dopamine resulting from the degeneration of the nigrostriatal dopaminergic projection neurons. An animal model for Parkinson's that has been extensively characterized involves the systemic administration of 1-methyl-4 phenyl 1,2,3,6-tetrahydropyridine (MPTP). In the CNS, MPTP is taken-up by astrocytes and catabolized by monoamine oxidase B to 1-methyl-4-phenyl pyridine (MPP⁺) and released. Subsequently, MPP⁺ is actively accumulated in dopaminergic neurons by the high-affinity reuptake transporter for dopamine. MPP⁺ is then concentrated in mitochondria by the electrochemical gradient and selectively inhibits nicotidamide adenine disphosphate: ubiquinone oxidoreductionase (complex I), thereby interfering with electron transport and eventually generating oxygen radicals.

[1151] It has been demonstrated in tissue culture paradigms that FGF-2 (basic FGF) has trophic activity towards nigral dopaminergic neurons (Ferrari et al., Dev. Biol. 1989). Recently, Dr. Unsicker's group has demonstrated that administering FGF-2 in gel foam implants in the striatum results in the near complete protection of nigral dopaminergic neurons from the toxicity associated with MPTP exposure (Otto and Unsicker, J. Neuroscience, 1990).

[1152] Based on the data with FGF-2, agonists or antagonists of the invention can be evaluated to determine whether it has an action similar to that of FGF-2 in enhancing dopaminergic neuronal survival in vitro and it can also be tested in vivo for protection of dopaminergic neurons in the striatum from the damage associated with MPTP treatment.

[1153] The potential effect of an agonist or antagonist of the invention is first examined in vitro in a dopaminergic neuronal cell culture paradigm. The cultures are prepared by dissecting the midbrain floor plate from gestation day 14 Wistar rat embryos. The tissue is dissociated with trypsin and seeded at a density of 200,000 cells/cm² on polyorthinine-laminin coated glass coverslips. The cells are maintained in Dulbecco's Modified Eagle's medium and F12 medium containing hormonal supplements (N1). The cultures are fixed with paraformaldehyde after 8 days in vitro and are processed for tyrosine hydroxylase, a specific marker for dopaminergic neurons, immunohistochemical staining. Dissociated cell cultures are prepared from embryonic rats. The culture medium is changed every third day and the factors are also added at that time.

[1154] Since the dopaminergic neurons are isolated from animals at gestation day 14, a developmental time which is past the stage when the dopaminergic precursor cells are proliferating, an increase in the number of tyrosine hydroxylase immunopositive neurons would represent an increase in the number of dopaminergic neurons surviving in vitro. Therefore, if an agonist or antagonist of the invention acts to prolong the survival of dopaminergic neurons, it would suggest that the agonist or antagonist may be involved in Parkinson's Disease.

[1155] The studies described in this example tested activity of agonists or antagonists of the invention. However, one skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides or polypeptides of the invention (e.g., gene therapy).

Example 25 The Effect of Agonists or Antagonists of the Invention on the Growth of Vascular Endothelial Cells

[1156] On day 1, human umbilical vein endothelial cells (HUVEC) are seeded at 2-5×10⁴ cells/35 mm dish density in M199 medium containing 4% fetal bovine serum (FBS), 16 units/ml heparin, and 50 units/ml endothelial cell growth supplements (ECGS, Biotechnique, Inc.). On day 2, the medium is replaced with M199 containing 10% FBS, 8 units/ml heparin. An agonist or antagonist of the invention, and positive controls, such as VEGF and basic FGF (bFGF) are added, at varying concentrations. On days 4 and 6, the medium is replaced. On day 8, cell number is determined with a Coulter Counter.

[1157] An increase in the number of HUVEC cells indicates that the compound of the invention may proliferate vascular endothelial cells, while a decrease in the number of HUVEC cells indicates that the compound of the invention inhibits vascular endothelial cells.

[1158] The studies described in this example tested activity of a polypeptide of the invention. However, one skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides (e.g., gene therapy), agonists, and/or antagonists of the invention.

Example 26 Rat Corneal Wound Healing Model

[1159] This animal model shows the effect of an agonist or antagonist of the invention on neovascularization. The experimental protocol includes:

[1160] Making a 1-1.5 mm long incision from the center of cornea into the stromal layer.

[1161] Inserting a spatula below the lip of the incision facing the outer comer of the eye.

[1162] Making a pocket (its base is 1-1.5 mm form the edge of the eye).

[1163] Positioning a pellet, containing 50ng-5ug of an agonist or antagonist of the invention, within the pocket.

[1164] Treatment with an agonist or antagonist of the invention can also be applied topically to the corneal wounds in a dosage range of 20mg -500mg (daily treatment for five days).

[1165] The studies described in this example tested activity of agonists or antagonists of the invention. However, one skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides or polypeptides of the invention (e.g., gene therapy).

Example 27 Diabetic Mouse and Glucocorticoid-Impaired Wound Healing Models

[1166] Diabetic db+/db+Mouse Model.

[1167] To demonstrate that an agonist or antagonist of the invention accelerates the healing process, the genetically diabetic mouse model of wound healing is used. The full thickness wound healing model in the db+/db+mouse is a well characterized, clinically relevant and reproducible model of impaired wound healing. Healing of the diabetic wound is dependent on formation of granulation tissue and re-epithelialization rather than contraction (Gartner, M. H. et al., J. Surg. Res. 52:389 (1992); Greenhalgh, D.G. et al., Am. J. Pathol. 136:1235 (1990)).

[1168] The diabetic animals have many of the characteristic features observed in Type II diabetes mellitus. Homozygous (db+/db+) mice are obese in comparison to their normal heterozygous (db+/+m) littermates. Mutant diabetic (db+/db+) mice have a single autosomal recessive mutation on chromosome 4 (db+) (Coleman et al. Proc. Natl. Acad. Sci. USA 77:283-293 (1982)). Animals show polyphagia, polydipsia and polyuria. Mutant diabetic mice (db+/db+) have elevated blood glucose, increased or normal insulin levels, and suppressed cell-mediated immunity (Mandel et al., J. Immunol. 120:1375 (1978); Debray-Sachs, M. et al., Clin. Exp. Immunol. 51(1):1-7 (1983); Leiter et al., Am. J. of Pathol. 114:46-55 (1985)). Peripheral neuropathy, myocardial complications, and microvascular lesions, basement membrane thickening and glomerular filtration abnormalities have been described in these animals (Norido, F. et al., Exp. Neurol. 83(2):221-232 (1984); Robertson et al., Diabetes 29(l):60-67 (1980); Giacomelli et al., Lab Invest. 40(4):460-473 (1979); Coleman, D. L., Diabetes 31 (Suppl):1-6 (1982)). These homozygous diabetic mice develop hyperglycemia that is resistant to insulin analogous to human type II diabetes (Mandel et al., J. Immunol. 120:1375-1377 (1978)).

[1169] The characteristics observed in these animals suggests that healing in this model may be similar to the healing observed in human diabetes (Greenhalgh, et al., Am. J. of Pathol. 136:1235-1246 (1990)).

[1170] Genetically diabetic female C57BL/KsJ (db+/db+) mice and their non-diabetic (db+/+m) heterozygous littermates are used in this study (Jackson Laboratories). The animals are purchased at 6 weeks of age and are 8 weeks old at the beginning of the study. Animals are individually housed and received food and water ad libitum. All manipulations are performed using aseptic techniques. The experiments are conducted according to the rules and guidelines of Human Genome Sciences, Inc. Institutional Animal Care and Use Committee and the Guidelines for the Care and Use of Laboratory Animals.

[1171] Wounding protocol is performed according to previously reported methods (Tsuboi, R. and Rifkin, D. B., J. Exp. Med. 172:245-251 (1990)). Briefly, on the day of wounding, animals are anesthetized with an intraperitoneal injection of Avertin (0.01 mg/mL), 2,2,2-tribromoethanol and 2-methyl-2-butanol dissolved in deionized water. The dorsal region of the animal is shaved and the skin washed with 70% ethanol solution and iodine. The surgical area is dried with sterile gauze prior to wounding. An 8 mm full-thickness wound is then created using a Keyes tissue punch. Immediately following wounding, the surrounding skin is gently stretched to eliminate wound expansion. The wounds are left open for the duration of the experiment. Application of the treatment is given topically for 5 consecutive days commencing on the day of wounding. Prior to treatment, wounds are gently cleansed with sterile saline and gauze sponges.

[1172] Wounds are visually examined and photographed at a fixed distance at the day of surgery and at two day intervals thereafter. Wound closure is determined by daily measurement on days 1-5 and on day 8. Wounds are measured horizontally and vertically using a calibrated Jameson caliper. Wounds are considered healed if granulation tissue is no longer visible and the wound is covered by a continuous epithelium.

[1173] An agonist or antagonist of the invention is administered using at a range different doses, from 4mg to 500 mg per wound per day for 8 days in vehicle. Vehicle control groups received 50 mL of vehicle solution.

[1174] Animals are euthanized on day 8 with an intraperitoneal injection of sodium pentobarbital (300 mg/kg). The wounds and surrounding skin are then harvested for histology and immunohistochemistry. Tissue specimens are placed in 10% neutral buffered formalin in tissue cassettes between biopsy sponges for further processing.

[1175] Three groups of 10 animals each (5 diabetic and 5 non-diabetic controls) are evaluated: 1) Vehicle placebo control, 2) untreated group, and 3) treated group.

[1176] Wound closure is analyzed by measuring the area in the vertical and horizontal axis and obtaining the total square area of the wound. Contraction is then estimated by establishing the differences between the initial wound area (day 0) and that of post treatment (day 8). The wound area on day 1 is 64mm², the corresponding size of the dermal punch. Calculations are made using the following formula:

[Open area on day 8]−[Open area on day 1]/[Open area on day 1]

[1177] Specimens are fixed in 10% buffered formalin and paraffin embedded blocks are sectioned perpendicular to the wound surface (5 mm) and cut using a Reichert-Jung microtome. Routine hematoxylin-eosin (H&E) staining is performed on cross-sections of bisected wounds. Histologic examination of the wounds are used to assess whether the healing process and the morphologic appearance of the repaired skin is altered by treatment with an agonist or antagonist of the invention. This assessment included verification of the presence of cell accumulation, inflammatory cells, capillaries, fibroblasts, re-epithelialization and epidermal maturity (Greenhalgh, D. G. et al., Am. J. Pathol. 136:1235 (1990)). A calibrated lens micrometer is used by a blinded observer.

[1178] Tissue sections are also stained immunohistochemically with a polyclonal rabbit anti-human keratin antibody using ABC Elite detection system. Human skin is used as a positive tissue control while non-immune IgG is used as a negative control. Keratinocyte growth is determined by evaluating the extent of reepithelialization of the wound using a calibrated lens micrometer.

[1179] Proliferating cell nuclear antigen/cyclin (PCNA) in skin specimens is demonstrated by using anti-PCNA antibody (1:50) with an ABC Elite detection system. Human colon cancer served as a positive tissue control and human brain tissue is used as a negative tissue control. Each specimen included a section with omission of the primary antibody and substitution with non-immune mouse IgG. Ranking of these sections is based on the extent of proliferation on a scale of 0-8, the lower side of the scale reflecting slight proliferation to the higher side reflecting intense proliferation.

[1180] Experimental data are analyzed using an unpaired t test. A p value of <0.05 is considered significant.

[1181] Steroid Impaired Rat Model

[1182] The inhibition of wound healing by steroids has been well documented in various in vitro and in vivo systems (Wahl, Glucocorticoids and Wound healing. In: Anti-Inflammatory Steroid Action: Basic and Clinical Aspects. 280-302 (1989); Wahl et al., J. Inmunol. 115: 476-481 (1975); Werb et al., J. Exp. Med. 147:1684-1694 (1978)). Glucocorticoids retard wound healing by inhibiting angiogenesis, decreasing vascular permeability (Ebert et al., An. Intern. Med. 37:701-705 (1952)), fibroblast proliferation, and collagen synthesis (Beck et al., Growth Factors. 5: 295-304 (1991); Haynes et al., J. Clin. Invest. 61: 703-797 (1978)) and producing a transient reduction of circulating monocytes (Haynes et al., J. Clin. Invest. 61: 703-797 (1978); Wahl, “Glucocorticoids and wound healing”, In: Antiinflammatory Steroid Action: Basic and Clinical Aspects, Academic Press, New York, pp. 280-302 (1989)). The systemic administration of steroids to impaired wound healing is a well establish phenomenon in rats (Beck et al., Growth Factors. 5: 295-304 (1991); Haynes et al., J. Clin. Invest. 61: 703-797 (1978); Wahl, “Glucocorticoids and wound healing”, In: Antiinflammatory Steroid Action: Basic and Clinical Aspects, Academic Press, New York, pp. 280-302 (1989); Pierce et al., Proc. Natl. Acad. Sci. USA 86: 2229-2233 (1989)).

[1183] To demonstrate that an agonist or antagonist of the invention can accelerate the healing process, the effects of multiple topical applications of the agonist or antagonist on full thickness excisional skin wounds in rats in which healing has been impaired by the systemic administration of methylprednisolone is assessed.

[1184] Young adult male Sprague Dawley rats weighing 250-300 g (Charles River Laboratories) are used in this example. The animals are purchased at 8 weeks of age and are 9 weeks old at the beginning of the study. The healing response of rats is impaired by the systemic administration of methylprednisolone (17 mg/kg/rat intramuscularly) at the time of wounding. Animals are individually housed and received food and water ad libitum. All manipulations are performed using aseptic techniques. This study is conducted according to the rules and guidelines of Human Genome Sciences, Inc. Institutional Animal Care and Use Committee and the Guidelines for the Care and Use of Laboratory Animals.

[1185] The wounding protocol is followed according to section A, above. On the day of wounding, animals are anesthetized with an intramuscular injection of ketamine (50 mg/kg) and xylazine (5 mg/kg). The dorsal region of the animal is shaved and the skin washed with 70% ethanol and iodine solutions. The surgical area is dried with sterile gauze prior to wounding. An 8 mm full-thickness wound is created using a Keyes tissue punch. The wounds are left open for the duration of the experiment. Applications of the testing materials are given topically once a day for 7 consecutive days commencing on the day of wounding and subsequent to methylprednisolone administration. Prior to treatment, wounds are gently cleansed with sterile saline and gauze sponges.

[1186] Wounds are visually examined and photographed at a fixed distance at the day of wounding and at the end of treatment. Wound closure is determined by daily measurement on days 1-5 and on day 8. Wounds are measured horizontally and vertically using a calibrated Jameson caliper. Wounds are considered healed if granulation tissue is no longer visible and the wound is covered by a continuous epithelium.

[1187] The agonist or antagonist of the invention is administered using at a range different doses, from 4mg to 500 mg per wound per day for 8 days in vehicle. Vehicle control groups received 50 mL of vehicle solution.

[1188] Animals are euthanized on day 8 with an intraperitoneal injection of sodium pentobarbital (300 mg/kg). The wounds and surrounding skin are then harvested for histology. Tissue specimens are placed in 10% neutral buffered formalin in tissue cassettes between biopsy sponges for further processing.

[1189] Three groups of 10 animals each (5 with methylprednisolone and 5 without glucocorticoid) are evaluated: 1) Untreated group 2) Vehicle placebo control 3) treated groups.

[1190] Wound closure is analyzed by measuring the area in the vertical and horizontal axis and obtaining the total area of the wound. Closure is then estimated by establishing the differences between the initial wound area (day 0) and that of post treatment (day 8). The wound area on day 1 is 64 mm2, the corresponding size of the dermal punch. Calculations are made using the following formula:

[Open area on day 8]−[Open area on day 1]/[Open area on day 1]

[1191] Specimens are fixed in 10% buffered formalin and paraffin embedded blocks are sectioned perpendicular to the wound surface (5 mm) and cut using an Olympus microtome. Routine hematoxylin-eosin (H&E) staining is performed on cross-sections of bisected wounds. Histologic examination of the wounds allows assessment of whether the healing process and the morphologic appearance of the repaired skin is improved by treatment with an agonist or antagonist of the invention. A calibrated lens micrometer is used by a blinded observer to determine the distance of the wound gap.

[1192] Experimental data are analyzed using an unpaired t test. A p value of <0.05 is considered significant.

[1193] The studies described in this example tested activity of agonists or antagonists of the invention. However, one skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides or polypeptides of the invention (e.g., gene therapy).

Example 28 Lymphadema Animal Model

[1194] The purpose of this experimental approach is to create an appropriate and consistent lymphedema model for testing the therapeutic effects of an agonist or antagonist of the invention in lymphangiogenesis and re-establishment of the lymphatic circulatory system in the rat hind limb. Effectiveness is measured by swelling volume of the affected limb, quantification of the amount of lymphatic vasculature, total blood plasma protein, and histopathology. Acute lymphedema is observed for 7-10 days. Perhaps more importantly, the chronic progress of the edema is followed for up to 3-4 weeks.

[1195] Prior to beginning surgery, blood sample is drawn for protein concentration analysis. Male rats weighing approximately ˜350 g are dosed with Pentobarbital. Subsequently, the right legs are shaved from knee to hip. The shaved area is swabbed with gauze soaked in 70% EtOH. Blood is drawn for serum total protein testing. Circumference and volumetric measurements are made prior to injecting dye into paws after marking 2 measurement levels (0.5 cm above heel, at mid-pt of dorsal paw). The intradermal dorsum of both right and left paws are injected with 0.05 ml of 1% Evan's Blue. Circumference and volumetric measurements are then made following injection of dye into paws.

[1196] Using the knee joint as a landmark, a mid-leg inguinal incision is made circumferentially allowing the femoral vessels to be located. Forceps and hemostats are used to dissect and separate the skin flaps. After locating the femoral vessels, the lymphatic vessel that runs along side and underneath the vessel(s) is located. The main lymphatic vessels in this area are then electrically coagulated or suture ligated.

[1197] Using a microscope, muscles in back of the leg (near the semitendinosis and adductors) are bluntly dissected. The popliteal lymph node is then located. The 2 proximal and 2 distal lymphatic vessels and distal blood supply of the popliteal node are then ligated by suturing. The popliteal lymph node, and any accompanying adipose tissue, is then removed by cutting connective tissues.

[1198] Care is taken to control any mild bleeding resulting from this procedure. After lymphatics are occluded, the skin flaps are sealed by using liquid skin (Vetbond) (AJ Buck). The separated skin edges are sealed to the underlying muscle tissue while leaving a gap of 0.5 cm around the leg. Skin also may be anchored by suturing to underlying muscle when necessary.

[1199] To avoid infection, animals are housed individually with mesh (no bedding). Recovering animals are checked daily through the optimal edematous peak, which typically occurred by day 5-7. The plateau edematous peak are then observed. To evaluate the intensity of the lymphedema, the circumference and volumes of 2 designated places on each paw before operation and daily for 7 days are measured. The effect of plasma proteins on lymphedema is determined and whether protein analysis is a useful testing perimeter is also investigated. The weights of both control and edematous limbs are evaluated at 2 places. Analysis is performed in a blind manner.

[1200] Circumference Measurements: Under brief gas anesthetic to prevent limb movement, a cloth tape is used to measure limb circumference. Measurements are done at the ankle bone and dorsal paw by 2 different people and those 2 readings are averaged. Readings are taken from both control and edematous limbs.

[1201] Volumetric Measurements: On the day of surgery, animals are anesthetized with Pentobarbital and are tested prior to surgery. For daily volumetrics animals are under brief halothane anesthetic (rapid immobilization and quick recovery), and both legs are shaved and equally marked using waterproof marker on legs. Legs are first dipped in water, then dipped into instrument to each marked level, then measured by Buxco edema software (Chen/Victor). Data is recorded by one person, while the other is dipping the limb to marked area.

[1202] Blood-plasma protein measurements: Blood is drawn, spun, and serum separated prior to surgery and then at conclusion for total protein and Ca²⁺ comparison.

[1203] Limb Weight Comparison: After drawing blood, the animal is prepared for tissue collection. The limbs are amputated using a quillitine, then both experimental and control legs are cut at the ligature and weighed. A second weighing is done as the tibio-cacaneal joint is disarticulated and the foot is weighed.

[1204] Histological Preparations: The transverse muscle located behind the knee (popliteal) area is dissected and arranged in a metal mold, filled with freezeGel, dipped into cold methylbutane, placed into labeled sample bags at −80 EC until sectioning. Upon sectioning, the muscle is observed under fluorescent microscopy for lymphatics.

[1205] The studies described in this example tested activity of agonists or antagonists of the invention. However, one skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides or polypeptides of the invention (e.g., gene therapy).

Example 29

[1206] Suppression of TNF Alpha-induced Adhesion Molecule Expression by a Agonist or Antagonist of the Invention

[1207] The recruitment of lymphocytes to areas of inflammation and angiogenesis involves specific receptor-ligand interactions between cell surface adhesion molecules (CAMs) on lymphocytes and the vascular endothelium. The adhesion process, in both normal and pathological settings, follows a multi-step cascade that involves intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule-1 (E-selectin) expression on endothelial cells (EC). The expression of these molecules and others on the vascular endothelium determines the efficiency with which leukocytes may adhere to the local vasculature and extravasate into the local tissue during the development of an inflammatory response. The local concentration of cytokines and growth factor participate in the modulation of the expression of these CAMs.

[1208] Tumor necrosis factor alpha (TNF-a), a potent proinflammatory cytokine, is a stimulator of all three CAMs on endothelial cells and may be involved in a wide variety of inflammatory responses, often resulting in a pathological outcome.

[1209] The potential of an agonist or antagonist of the invention to mediate a suppression of TNF-a induced CAM expression can be examined. A modified ELISA assay which uses ECs as a solid phase absorbent is employed to measure the amount of CAM expression on TNF-a treated ECs when co-stimulated with a member of the FGF family of proteins.

[1210] To perform the experiment, human umbilical vein endothelial cell (HUVEC) cultures are obtained from pooled cord harvests and maintained in growth medium (EGM-2; Clonetics, San Diego, Calif.) supplemented with 10% FCS and 1% penicillin/streptomycin in a 37 degree C. humidified incubator containing 5% CO₂. HUVECs are seeded in 96-well plates at concentrations of 1×10⁴ cells/well in EGM medium at 37 degree C. for 18-24 hrs or until confluent. The monolayers are subsequently washed 3 times with a serum-free solution of RPMI-1640 supplemented with 100 U/ml penicillin and 100 mg/ml streptomycin, and treated with a given cytokine and/or growth factor(s) for 24 h at 37 degree C. Following incubation, the cells are then evaluated for CAM expression.

[1211] Human Umbilical Vein Endothelial cells (HUVECs) are grown in a standard 96 well plate to confluence. Growth medium is removed from the cells and replaced with 90 ul of 199 Medium (10% FBS). Samples for testing and positive or negative controls are added to the plate in triplicate (in 10 ul volumes). Plates are incubated at 37 degree C. for either 5 h (selectin and integrin expression) or 24 h (integrin expression only). Plates are aspirated to remove medium and 100 μl of 0.1% paraformaldehyde-PBS(with Ca++ and Mg++) is added to each well. Plates are held at 4° C. for 30 min.

[1212] Fixative is then removed from the wells and wells are washed 1× with PBS(+Ca,Mg)+0.5% BSA and drained. Do not allow the wells to dry. Add 10 μl of diluted primary antibody to the test and control wells. Anti-ICAM-1-Biotin, Anti-VCAM-1-Biotin and Anti-E-selectin-Biotin are used at a concentration of 10 μg/ml (1:10 dilution of 0.1 mg/ml stock antibody). Cells are incubated at 37° C. for 30 min. in a humidified environment. Wells are washed ×3 with PBS(+Ca,Mg)+0.5% BSA.

[1213] Then add 20 μl of diluted ExtrAvidin-Alkaline Phosphotase (1:5,000 dilution) to each well and incubated at 37° C. for 30 min. Wells are washed ×3 with PBS(+Ca,Mg)+0.5% BSA. 1 tablet of p-Nitrophenol Phosphate pNPP is dissolved in 5 ml of glycine buffer (pH 10.4). 100 μl of pNPP substrate in glycine buffer is added to each test well. Standard wells in triplicate are prepared from the working dilution of the ExtrAvidin-Alkaline Phosphotase in glycine buffer: 1:5,000 (10⁰)>10^(−0.5)>10⁻¹>10^(−1.5).5 μl of each dilution is added to triplicate wells and the resulting AP content in each well is 5.50 ng, 1.74 ng, 0.55 ng, 0.18 ng. 100 μl of pNNP reagent must then be added to each of the standard wells. The plate must be incubated at 37° C. for 4 h. A volume of 50 μl of 3M NaOH is added to all wells. The results are quantified on a plate reader at 405 nm. The background subtraction option is used on blank wells filled with glycine buffer only. The template is set up to indicate the concentration of AP-conjugate in each standard well [ 5.50 ng; 1.74 ng; 0.55 ng; 0.18 ng]. Results are indicated as amount of bound AP-conjugate in each sample.

[1214] The studies described in this example tested activity of agonists or antagonists of the invention. However, one skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides or polypeptides of the invention (e.g., gene therapy).

Example 30 Production Of Polypeptide of the Invention For High-Throughput Screening Assays

[1215] The following protocol produces a supernatant containing polypeptide of the present invention to be tested. This supernatant can then be used in the Screening Assays described in Examples 32-41.

[1216] First, dilute Poly-D-Lysine (644 587 Boelringer-Mannheim) stock solution (1 mg/ml in PBS) 1:20 in PBS (w/o calcium or magnesium 17-516F Biowhittaker) for a working solution of 50 ug/ml. Add 200 ul of this solution to each well (24 well plates) and incubate at RT for 20 minutes. Be sure to distribute the solution over each well (note: a 12-channel pipetter may be used with tips on every other channel). Aspirate off the Poly-D-Lysine solution and rinse with 1ml PBS (Phosphate Buffered Saline). The PBS should remain in the well until just prior to plating the cells and plates may be poly-lysine coated in advance for up to two weeks.

[1217] Plate 293T cells (do not carry cells past P+20) at 2×10⁵ cells/well in 0.5 ml DMEM(Dulbecco's Modified Eagle Medium)(with 4.5 G/L glucose and L-glutamine (12-604F Biowhittaker))/10% heat inactivated FBS(14-503F Biowhittaker)/1×Penstrep(17-602E Biowhittaker). Let the cells grow overnight.

[1218] The next day, mix together in a sterile solution basin: 300 ul Lipofectamine (18324-012 Gibco/BRL) and 5 ml Optimem I (31985070 Gibco/BRL)/96-well plate. With a small volume multi-channel pipetter, aliquot approximately 2 ug of an expression vector containing a polynucleotide insert, produced by the methods described in Examples 8-10, into an appropriately labeled 96-well round bottom plate.

[1219] With a multi-channel pipetter, add 50 ul of the Lipofectamine/Optimem I mixture to each well. Pipette up and down gently to mix. Incubate at RT 15-45 minutes. After about 20 minutes, use a multi-channel pipetter to add 150 ul Optimem I to each well. As a control, one plate of vector DNA lacking an insert should be transfected with each set of transfections.

[1220] Preferably, the transfection should be performed by tag-teaming the following tasks. By tag-teaming, hands on time is cut in half, and the cells do not spend too much time on PBS. First, person A aspirates off the media from four 24-well plates of cells, and then person B rinses each well with 0.5-1 ml PBS. Person A then aspirates off PBS rinse, and person B, using a 12-channel pipetter with tips on every other channel, adds the 200 ul of DNA/Lipofectamine/Optimem I complex to the odd wells first, then to the even wells, to each row on the 24-well plates. Incubate at 37 degree C. for 6 hours.

[1221] While cells are incubating, prepare appropriate media, either 1% BSA in DMEM with 1× penstrep, or HGS CHO-5 media (116.6 mg/L of CaCl2 (anhyd); 0.00130 mg/L CuSO₄-5H₂O; 0.050 mg/L of Fe(NO₃)₃-9H₂O; 0.417 mg/L of FeSO₄-7H₂O; 311.80 mg/L of Kcl; 28.64 mg/L of MgCl₂; 48.84 mg/L of MgSO₄; 6995.50 mg/L of NaCl; 2400.0 mg/L of NaHCO₃; 62.50 mg/L of NaH₂PO₄-H₂O; 71.02 mg/L of Na₂HPO4; 0.4320 mg/L of ZnSO₄-7H₂O; 0.002 mg/L of Arachidonic Acid; 1.022 mg/L of Cholesterol; 0.070 mg/L of DL-alpha-Tocopherol-Acetate; 0.0520 mg/L of Linoleic Acid; 0.010 mg/L of Linolenic Acid; 0.010 mg/L of Myristic Acid; 0.010 mg/L of Oleic Acid; 0.010 mg/L of Palmitric Acid; 0.010 mg/L of Palmitic Acid; 100 mg/L of Pluronic F-68; 0.010 mg/L of Stearic Acid; 2.20 mg/L of Tween 80; 4551 mg/L of D-Glucose; 130.85 mg/ml of L- Alanine; 147.50 mg/ml of L-Arginine-HCL; 7.50 mg/ml of L-Asparagine-H₂O; 6.65 mg/ml of L-Aspartic Acid; 29.56 mg/ml of L-Cystine-2HCL-H₂O; 31.29 mg/ml of L-Cystine-2HCL; 7.35 mg/ml of L-Glutamic Acid; 365.0 mg/ml of L-Glutamine; 18.75 mg/ml of Glycine; 52.48 mg/ml of L-Histidine-HCL-H₂O; 106.97 mg/ml of L-Isoleucine; 111.45 mg/ml of L-Leucine; 163.75 mg/ml of L-Lysine HCL; 32.34 mg/ml of L-Methionine; 68.48 mg/ml of L-Phenylalainine; 40.0 mg/ml of L-Proline; 26.25 mg/ml of L-Serine; 101.05 mg/ml of L-Threonine; 19.22 mg/ml of L-Tryptophan; 91.79 mg/ml of L-Tryrosine-2Na-2H₂O; and 99.65 mg/ml of L-Valine; 0.0035 mg/L of Biotin; 3.24 mg/L of D-Ca Pantothenate; 11.78 mg/L of Choline Chloride; 4.65 mg/L of Folic Acid; 15.60 mg/L of i-Inositol; 3.02 mg/L of Niacinamide; 3.00 mg/L of Pyridoxal HCL; 0.031 mg/L of Pyridoxine HCL; 0.319 mg/L of Riboflavin; 3.17 mg/L of Thiamine HCL; 0.365 mg/L of Thymidine; 0.680 mg/L of Vitamin B₁₂; 25 mM of HEPES Buffer; 2.39 mg/L of Na Hypoxanthine; 0.105 mg/L of Lipoic Acid; 0.081 mg/L of Sodium Putrescine-2HCL; 55.0 mg/L of Sodium Pyruvate; 0.0067 mg/L of Sodium Selenite; 20 uM of Ethanolamine; 0.122 mg/L of Ferric Citrate; 41.70 mg/L of Methyl-B-Cyclodextrin complexed with Linoleic Acid; 33.33 mgl of Methyl-B-Cyclodextrin complexed with Oleic Acid; 10 mg/L of Methyl-B-Cyclodextrin complexed with Retinal Acetate. Adjust osmolarity to 327 mOsm) with 2 mm glutamine and 1x penstrep. (BSA (81-068-3 Bayer) 100 gm dissolved in 1L DMEM for a 10% BSA stock solution). Filter the media and collect 50 ul for endotoxin assay in 15 ml polystyrene conical.

[1222] The transfection reaction is terminated, preferably by tag-teaming, at the end of the incubation period. Person A aspirates off the transfection media, while person B adds 1.5 ml appropriate media to each well. Incubate at 37 degree C. for 45 or 72 hours depending on the media used: 1% BSA for 45 hours or CHO-5 for 72 hours.

[1223] On day four, using a 300 ul multichannel pipetter, aliquot 600 ul in one Iml deep well plate and the remaining supernatant into a 2 ml deep well. The supernatants from each well can then be used in the assays described in Examples 32-39.

[1224] It is specifically understood that when activity is obtained in any of the assays described below using a supernatant, the activity originates from either the polypeptide of the present invention directly (e.g., as a secreted protein) or by polypeptide of the present invention inducing expression of other proteins, which are then secreted into the supernatant. Thus, the invention further provides a method of identifying the protein in the supernatant characterized by an activity in a particular assay.

Example 31 Construction of GAS Reporter Construct

[1225] One signal transduction pathway involved in the differentiation and proliferation of cells is called the Jaks-STATs pathway. Activated proteins in the Jaks-STATs pathway bind to gamma activation site “GAS” elements or interferon-sensitive responsive element (“ISRE”), located in the promoter of many genes. The binding of a protein to these elements alter the expression of the associated gene.

[1226] GAS and ISRE elements are recognized by a class of transcription factors called Signal Transducers and Activators of Transcription, or “STATs.” There are six members of the STATs family. Stat1 and Stat3 are present in many cell types, as is Stat2 (as response to IFN-alpha is widespread). Stat4 is more restricted and is not in many cell types though it has been found in T helper class I, cells after treatment with IL-12. Stat5 was originally called mammary growth factor, but has been found at higher concentrations in other cells including myeloid cells. It can be activated in tissue culture cells by many cytokines.

[1227] The STATs are activated to translocate from the cytoplasm to the nucleus upon tyrosine phosphorylation by a set of kinases known as the Janus Kinase (“Jaks”) family. Jaks represent a distinct family of soluble tyrosine kinases and include Tyk2, Jak1, Jak2, and Jak3. These kinases display significant sequence similarity and are generally catalytically inactive in resting cells.

[1228] The Jaks are activated by a wide range of receptors summarized in the Table below. (Adapted from review by Schidler and Darnell, Ann. Rev. Biochem. 64:621-51 (1995).) A cytokine receptor family, capable of activating Jaks, is divided into two groups: (a) Class 1 includes receptors for IL-2, IL-3, IL-4, IL-6, IL-7, IL-9, IL-11, IL-12, IL-15, Epo, PRL, GH, G-CSF, GM-CSF, LIF, CNTF, and thrombopoietin; and (b) Class 2 includes IFN-a, IFN-g, and IL-10. The Class 1 receptors share a conserved cysteine motif (a set of four conserved cysteines and one tryptophan) and a WSXWS motif (a membrane proximal region encoding Trp-Ser-Xaa-Trp-Ser (SEQ ID NO: 2)).

[1229] Thus, on binding of a ligand to a receptor, Jaks are activated, which in turn activate STATs, which then translocate and bind to GAS elements. This entire process is encompassed in the Jaks-STATs signal transduction pathway.

[1230] Therefore, activation of the Jaks-STATs pathway, reflected by the binding of the GAS or the ISRE element, can be used to indicate proteins involved in the proliferation and differentiation of cells. For example, growth factors and cytokines are known to activate the Jaks-STATs pathway. (See Table below.) Thus, by using GAS elements linked to reporter molecules, activators of the Jaks-STATs pathway can be identified. JAKs GAS (elements) Ligand tyk2 Jak1 Jak2 Jak3 STATS or ISRE IFN family IFN-a/B + + − − 1,2,3 ISRE IFN-g + + − 1 GAS (IRF1 > Lys6 > IFP) I1-10 + ? ? − 1,3 gp130 family IL-6 (Pleiotropic) + + + ? 1,3 GAS (IRF1 > Lys6 > IFP) I1-11 (Pleiotropic) ? + ? ? 1,3 OnM (Pleiotropic) ? + + ? 1,3 LIF (Pleiotropic) ? + + ? 1,3 CNTF (Pleiotropic) −/+ + + ? 1,3 G-CSF (Pleiotropic) ? + ? ? 1,3 IL-12 (Pleiotropic) + − + + 1,3 g-C family IL-2 (lymphocytes) − + − + 1,3,5 GAS IL-4 (lymph/myeloid) − + − + 6 GAS (IRF1 = IFP >> Ly6)(IgH) IL-7 (lymphocytes) − + − + 5 GAS IL-9 (lymphocytes) − + − + 5 GAS IL-13 (lymphocyte) − + ? ? 6 GAS IL-15 ? + ? + 5 GAS gp140 family IL-3 (myeloid) − − + − 5 GAS (IRF1 > IFP >> Ly6) IL-5 (myeloid) − − + − 5 GAS GM-CSF (myeloid) − − + − 5 GAS Growth hormone family GH ? − + − 5 PRL ? +/− + − 1,3,5 EPO ? − + − 5 GAS(B − CAS > IRF1 = IFP >> Ly6) Receptor Tyrosine Kinases EGF ? + + − 1,3 GAS (IRF1) PDGF ? + + − 1,3 CSF-1 ? + + − 1,3 GAS (not IRF1)

[1231] To construct a synthetic GAS containing promoter element, which is used in the Biological Assays described in Examples 32-33, a PCR based strategy is employed to generate a GAS-SV40 promoter sequence. The 5′ primer contains four tandem copies of the GAS binding site found in the IRF1 promoter and previously demonstrated to bind STATs upon induction with a range of cytokines (Rothman et al., Immunity 1:457-468 (1994).), although other GAS or ISRE elements can be used instead. The 5′ primer also contains 18bp of sequence complementary to the SV40 early promoter sequence and is flanked with an XhoI site. The sequence of the 5′ primer is: 5′:GCGCCTCGAGATTTCCCCGAAATCTAGATTTCCC (SEQ ID NO:3) CGAAATGATTTCCCCGAAATGATTTCCCCGAAATATC TGCCATCTCAATTAG:3′

[1232] The downstream primer is complementary to the SV40 promoter and is flanked with a Hind III site: 5′:GCGGCAAGCTTTTTGCAAAGCCTAGGC:3′(SEQ ID NO:4.

[1233] PCR amplification is performed using the SV40 promoter template present in the B-gal:promoter plasmid obtained from Clontech. The resulting PCR fragment is digested with XhoI/Hind III and subcloned into BLSK2-. (Stratagene.) Sequencing with forward and reverse primers confirms that the insert contains the following sequence: 5′:CTCGAGATTTCCCCGAAATCTAGATTTCCCCGAAATG (SEQ ID NO:5) ATTTCCCCGAAATGATTTCCCCGAAATATCTGCCATC TCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCC GCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCAT TCTCCGCCCCATGGCTGACTAATTTTTTTTTATTTAT GCAGAGGCCGAGGCCGCCTCGGCCTCTGAGCTATTCC AGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTT TTGCAAAAAGCTT:3′

[1234] With this GAS promoter element linked to the SV40 promoter, a GAS:SEAP2 reporter construct is next engineered. Here, the reporter molecule is a secreted alkaline phosphatase, or “SEAP.” Clearly, however, any reporter molecule can be used instead of SEAP, in this or in any of the other Examples. Well known reporter molecules that can be used instead of SEAP include chloramphenicol acetyltransferase (CAT), luciferase, alkaline phosphatase, B-galactosidase, green fluorescent protein (GFP), or any protein detectable by an antibody.

[1235] The above sequence confirmed synthetic GAS-SV40 promoter element is subcloned into the pSEAP-Promoter vector obtained from Clontech using HindIII a and XhoI, effectively replacing the SV40 promoter with the amplified GAS:SV40 promoter element, to create the GAS-SEAP vector. However, this vector does not contain a neomycin resistance gene, and therefore, is not preferred for mammalian expression systems.

[1236] Thus, in order to generate mammalian stable cell lines expressing the GAS-SEAP reporter, the GAS-SEAP cassette is removed from the GAS-SEAP vector using SalI and NotI, and inserted into a backbone vector containing the neomycin resistance gene, such as pGFP-1 (Clontech), using these restriction sites in the multiple cloning site, to create the GAS-SEAP/Neo vector. Once this vector is transfected into mammalian cells, this vector can then be used as a reporter molecule for GAS binding as described in Examples 32-33.

[1237] Other constructs can be made using the above description and replacing GAS with a different promoter sequence. For example, construction of reporter molecules containing NFK-B and EGR promoter sequences are described in Examples 34 and 35. However, many other promoters can be substituted using the protocols described in these Examples. For instance, SRE, IL-2, NFAT, or Osteocalcin promoters can be substituted, alone or in combination (e.g., GAS/NF-KB/EGR, GAS/NF-KB, Il-2/NFAT, or NF-KB/GAS). Similarly, other cell lines can be used to test reporter construct activity, such as HELA (epithelial), HUVEC (endothelial), Reh (B-cell), Saos-2 (osteoblast), HUVAC (aortic), or Cardiomyocyte.

Example 32 High-Throughput Screening Assay for T-cell Activity.

[1238] The following protocol is used to assess T-cell activity by identifying factors, and determining whether supemate containing a polypeptide of the invention proliferates and/or differentiates T-cells. T-cell activity is assessed using the GAS/SEAP/Neo construct produced in Example 31. Thus, factors that increase SEAP activity indicate the ability to activate the Jaks-STATS signal transduction pathway. The T-cell used in this assay is Jurkat T-cells (ATCC Accession No. TIB-152), although Molt-3 cells (ATCC Accession No. CRL-1552) and Molt-4 cells (ATCC Accession No. CRL-1582) cells can also be used.

[1239] Jurkat T-cells are lymphoblastic CD4+Thl helper cells. In order to generate stable cell lines, approximately 2 million Jurkat cells are transfected with the GAS-SEAP/neo vector using DMRIE-C (Life Technologies)(transfection procedure described below). The transfected cells are seeded to a density of approximately 20,000 cells per well and transfectants resistant to 1 mg/ml genticin selected. Resistant colonies are expanded and then tested for their response to increasing concentrations of interferon gamma. The dose response of a selected clone is demonstrated.

[1240] Specifically, the following protocol will yield sufficient cells for 75 wells containing 200 ul of cells. Thus, it is either scaled up, or performed in multiple to generate sufficient cells for multiple 96 well plates. Jurkat cells are maintained in RPMI+10% serum with 1% Pen-Strep. Combine 2.5 mls of OPTI-MEM (Life Technologies) with 10 ug of plasmid DNA in a T25 flask. Add 2.5 ml OPTI-MEM containing 50 ul of DMRIE-C and incubate at room temperature for 15-45 mins.

[1241] During the incubation period, count cell concentration, spin down the required number of cells (10⁷ per transfection), and resuspend in OPTI-MEM to a final concentration of 10⁷ cells/ml. Then add 1 ml of 1×10⁷ cells in OPTI-MEM to T25 flask and incubate at 37 degree C. for 6 hrs. After the incubation, add 10 ml of RPMI+15% serum.

[1242] The Jurkat:GAS-SEAP stable reporter lines are maintained in RPMI+10% serum, 1 mg/ml Genticin, and 1% Pen-Strep. These cells are treated with supernatants containing polypeptide of the present invention or polypeptide of the present invention induced polypeptides as produced by the protocol described in Example 30.

[1243] On the day of treatment with the supernatant, the cells should be washed and resuspended in fresh RPMI +10% serum to a density of 500,000 cells per ml. The exact number of cells required will depend on the number of supernatants being screened. For one 96 well plate, approximately 10 million cells (for 10 plates, 100 million cells) are required.

[1244] Transfer the cells to a triangular reservoir boat, in order to dispense the cells into a 96 well dish, using a 12 channel pipette. Using a 12 channel pipette, transfer 200 ul of cells into each well (therefore adding 100,000 cells per well).

[1245] After all the plates have been seeded, 50 ul of the supernatants are transferred directly from the 96 well plate containing the supernatants into each well using a 12 channel pipette. In addition, a dose of exogenous interferon gamma (0.1, 1.0, 10 ng) is added to wells H9, H10, and H11 to serve as additional positive controls for the assay.

[1246] The 96 well dishes containing Jurkat cells treated with supernatants are placed in an incubator for 48 hrs (note: this time is variable between 48-72 hrs). 35 ul samples from each well are then transferred to an opaque 96 well plate using a 12 channel pipette. The opaque plates should be covered (using sellophene covers) and stored at −20 degree C. until SEAP assays are performed according to Example 36. The plates containing the remaining treated cells are placed at 4 degree C. and serve as a source of material for repeating the assay on a specific well if desired.

[1247] As a positive control, 100 Unit/ml interferon gamma can be used which is known to activate Jurkat T cells. Over 30 fold induction is typically observed in the positive control wells.

[1248] The above protocol may be used in the generation of both transient, as well as stable, transfected cells, which would be apparent to those of skill in the art.

Example 33 High-Throughput Screening Assay Identifying Myeloid Activity

[1249] The following protocol is used to assess myeloid activity of polypeptide of the present invention by determining whether polypeptide of the present invention proliferates and/or differentiates myeloid cells. Myeloid cell activity is assessed using the GAS/SEAP/Neo construct produced in Example 31. Thus, factors that increase SEAP activity indicate the ability to activate the Jaks-STATS signal transduction pathway. The myeloid cell used in this assay is U937, a pre-monocyte cell line, although TF-1, HL60, or KG1 can be used.

[1250] To transiently transfect U937 cells with the GAS/SEAP/Neo construct produced in Example 31, a DEAE-Dextran method (Kharbanda et. al., 1994, Cell Growth & Differentiation, 5:259-265) is used. First, harvest 2×10 U937 cells and wash with PBS. The U937 cells are usually grown in RPMI 1640 medium containing 10% heat-inactivated fetal bovine serum (FBS) supplemented with 100 units/ml penicillin and 100 mg/ml streptomycin.

[1251] Next, suspend the cells in 1 ml of 20 mM Tris-HCl (pH 7.4) buffer containing 0.5 mg/ml DEAE-Dextran, 8 ug GAS-SEAP2 plasmid DNA, 140 mM NaCl, 5 mM KCl, 375 uM Na₂HPO₄.7H₂O, 1 mM MgCl₂, and 675 uM CaCl₂. Incubate at 37 degrees C. for 45 min.

[1252] Wash the cells with RPMI 1640 medium containing 10% FBS and then resuspend in 10 ml complete medium and incubate at 37 degree C. for 36 hr.

[1253] The GAS-SEAP/U937 stable cells are obtained by growing the cells in 400 ug/ml G418. The G418-free medium is used for routine growth but every one to two months, the cells should be re-grown in 400 ug/ml G418 for couple of passages.

[1254] These cells are tested by harvesting 1×10⁸ cells (this is enough for ten 96-well plates assay) and wash with PBS. Suspend the cells in 200 ml above described growth medium, with a final density of 5×10⁵ cells/ml. Plate 200 ul cells per well in the 96-well plate (or 1×10⁵ cells/well).

[1255] Add 50 ul of the supernatant prepared by the protocol described in Example 30. Incubate at 37 degee C. for 48 to 72 hr. As a positive control, 100 Unit/ml interferon gamma can be used which is known to activate U937 cells. Over 30 fold induction is typically observed in the positive control wells. SEAP assay the supernatant according to the protocol described in Example 36.

Example 34 High-Throughput Screening Assay Identifying Neuronal Activity.

[1256] When cells undergo differentiation and proliferation, a group of genes are activated through many different signal transduction pathways. One of these genes, EGRI (early growth response gene 1), is induced in various tissues and cell types upon activation. The promoter of EGRI is responsible for such induction. Using the EGR1 promoter linked to reporter molecules, activation of cells can be assessed by polypeptide of the present invention.

[1257] Particularly, the following protocol is used to assess neuronal activity in PC12 cell lines. PC12 cells (rat phenochromocytoma cells) are known to proliferate and/or differentiate by activation with a number of mitogens, such as TPA (tetradecanoyl phorbol acetate), NGF (nerve growth factor), and EGF (epidermal growth factor). The EGRI gene expression is activated during this treatment. Thus, by stably transfecting PC12 cells with a construct containing an EGR promoter linked to SEAP reporter, activation of PC12 cells by polypeptide of the present invention can be assessed.

[1258] The EGR/SEAP reporter construct can be assembled by the following protocol. The EGR-1 promoter sequence (−633 to +1)(Sakamoto K et al., Oncogene 6:867-871 (1991)) can be PCR amplified from human genomic DNA using the following primers: 5′ GCGCTCGAGGGATGACAGCGATAGAACCCCGG- (SEQ ID NO:6) 3′ 5′ GCGAAGCTTCGCGACTCCCCGGATCCGCCTC-3′ (SEQ ID NO:7)

[1259] Using the GAS:SEAP/Neo vector produced in Example 31, EGRI amplified product can then be inserted into this vector. Linearize the GAS:SEAP/Neo vector using restriction enzymes XhoI/HindIII, removing the GAS/SV40 stuffer. Restrict the EGR1 amplified product with these same enzymes. Ligate the vector and the EGRI promoter.

[1260] To prepare 96 well-plates for cell culture, two mls of a coating solution (1:30 dilution of collagen type I (Upstate Biotech Inc. Cat#08-115) in 30% ethanol (filter sterilized)) is added per one 10 cm plate or 50 ml per well of the 96-well plate, and allowed to air dry for 2 hr.

[1261] PC12 cells are routinely grown in RPMI-1640 medium (Bio Whittaker) containing 10% horse serum (JRH BIOSCIENCES, Cat. # 12449-78P), 5% heat-inactivated fetal bovine serum (FBS) supplemented with 100 units/ml penicillin and 100 ug/ml streptomycin on a precoated 10 cm tissue culture dish. One to four split is done every three to four days. Cells are removed from the plates by scraping and resuspended with pipetting up and down for more than 15 times.

[1262] Transfect the EGR/SEAP/Neo construct into PC12 using the Lipofectamine protocol described in Example 30. EGR-SEAP/PC12 stable cells are obtained by growing the cells in 300 ug/ml G418. The G418-free medium is used for routine growth but every one to two months, the cells should be re-grown in 300 ug/ml G418 for couple of passages.

[1263] To assay for neuronal activity, a 10 cm plate with cells around 70 to 80% confluent is screened by removing the old medium. Wash the cells once with PBS (Phosphate buffered saline). Then starve the cells in low serum medium (RPMI-1640 containing 1% horse serum and 0.5% FBS with antibiotics) overnight.

[1264] The next morning, remove the medium and wash the cells with PBS. Scrape off the cells from the plate, suspend the cells well in 2 ml low serum medium. Count the cell number and add more low serum medium to reach final cell density as 5×10⁵ cells/ml.

[1265] Add 200 ul of the cell suspension to each well of 96-well plate (equivalent to 1×10⁵ cells/well). Add 50 ul supernatant produced by Example 30, 37 degree C. for 48 to 72 hr. As a positive control, a growth factor known to activate PC12 cells through EGR can be used, such as 50 ng/ul of Neuronal Growth Factor (NGF). Over fifty-fold induction of SEAP is typically seen in the positive control wells. SEAP assay the supernatant according to Example 36.

Example 35 High-Throughput Screening Assay for T-cell Activity

[1266] NF-KB (Nuclear Factor KB) is a transcription factor activated by a wide variety of agents including the inflammatory cytokines IL-1 and TNF, CD30 and CD40, lymphotoxin-alpha and lymphotoxin-beta, by exposure to LPS or thrombin, and by expression of certain viral gene products. As a transcription factor, NF-KB regulates the expression of genes involved in immune cell activation, control of apoptosis (NF-KB appears to shield cells from apoptosis), B and T-cell development, anti-viral and antimicrobial responses, and multiple stress responses.

[1267] In non-stimulated conditions, NF-KB is retained in the cytoplasm with I-KB (Inhibitor KB). However, upon stimulation, I-KB is phosphorylated and degraded, causing NF-KB to shuttle to the nucleus, thereby activating transcription of target genes. Target genes activated by NF-KB include IL-2, IL-6, GM-CSF, ICAM-1 and class 1 MHC.

[1268] Due to its central role and ability to respond to a range of stimuli, reporter constructs utilizing the NF-KB promoter element are used to screen the supernatants produced in Example 30. Activators or inhibitors of NF-KB would be useful in treating, preventing, and/or diagnosing diseases. For example, inhibitors of NF-KB could be used to treat those diseases related to the acute or chronic activation of NF-KB, such as rheumatoid arthritis.

[1269] To construct a vector containing the NF-KB promoter element, a PCR based strategy is employed. The upstream primer contains four tandem copies of the NF-KB binding site (GGGGACTTTCCC) (SEQ ID NO: 8), 18 bp of sequence complementary to the 5′ end of the SV40 early promoter sequence, and is flanked with an XhoI site: 5′:GCGGCCTCGAGGGGACTTTCCCGGGGACTTTCCG (SEQ ID NO:9) GGGACTTTCCGGGACTTTCCATCCTGCCATCTCAATT AG:3′

[1270] The downstream primer is complementary to the 3′ end of the SV40 promoter and is flanked with a Hind III site:

[1271] 5′:GCGGCAAGCTTTTTGCAAAGCCTAGGC:3′ (SEQ ID NO:4

[1272] PCR amplification is performed using the SV40 promoter template present in the pB-gal:promoter plasmid obtained from Clontech. The resulting PCR fragment is digested with XhoI and Hind III and subcloned into BLSK2-. (Stratagene) Sequencing with the T7 and T3 primers confirms the insert contains the following sequence: 5′:CTCGAGGGGACTTTCCCGGGGACTTTCCGGGGA (SEQ ID NO:10) CTTTCCGGGACTTTCCATCTGCCATCTCAATTAGTC AGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCC GCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCC CCATGGCTGACTAATTTTTTTTATTTATGCAGAGGC CGAGGCCGCCTCGGCCTCTGAGCTATTCCAGAAGTA GTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAA AAAGCTT:3′

[1273] Next, replace the SV40 minimal promoter element present in the pSEAP2-promoter plasmid (Clontech) with this NF-KB/SV40 fragment using XhoI and HindIII. However, this vector does not contain a neomycin resistance gene, and therefore, is not preferred for mammalian expression systems.

[1274] In order to generate stable mammalian cell lines, the NF-KB/SV40/SEAP cassette is removed from the above NF-KB/SEAP vector using restriction enzymes SalI and NotI, and inserted into a vector containing neomycin resistance. Particularly, the NF-KB/SV40/SEAP cassette was inserted into pGFP-1 (Clontech), replacing the GFP gene, after restricting pGFP-1 with SalI and NotI.

[1275] Once NF-KB/SV40/SEAP/Neo vector is created, stable Jurkat T-cells are created and maintained according to the protocol described in Example 32. Similarly, the method for assaying supernatants with these stable Jurkat T-cells is also described in Example 32. As a positive control, exogenous TNF alpha (0.1,1, 10 ng) is added to wells H9, H10, and H11, with a 5-10 fold activation typically observed.

Example 36 Assay for SEAP Activity

[1276] As a reporter molecule for the assays described in Examples 32-35, SEAP activity is assayed using the Tropix Phospho-light Kit (Cat. BP-400) according to the following general procedure. The Tropix Phospho-light Kit supplies the Dilution, Assay, and Reaction Buffers used below.

[1277] Prime a dispenser with the 2.5×Dilution Buffer and dispense 15 ul of 2.5×dilution buffer into Optiplates containing 35 ul of a supernatant. Seal the plates with a plastic sealer and incubate at 65 degree C. for 30 min. Separate the Optiplates to avoid uneven heating.

[1278] Cool the samples to room temperature for 15 minutes. Empty the dispenser and prime with the Assay Buffer. Add 50 ml Assay Buffer and incubate at room temperature 5 min. Empty the dispenser and prime with the Reaction Buffer (see the Table below). Add 50 ul Reaction Buffer and incubate at room temperature for 20 minutes. Since the intensity of the chemiluminescent signal is time dependent, and it takes about 10 minutes to read 5 plates on a luminometer, thus one should treat 5 plates at each time and start the second set 10 minutes later.

[1279] Read the relative light unit in the luminometer. Set H12 as blank, and print the results. An increase in chemiluminescence indicates reporter activity. Reaction Buffer Formulation: # of plates Rxn buffer diluent (ml) CSPD (ml) 10 60 3 11 65 3.25 12 70 3.5 13 75 3.75 14 80 4 15 85 4.25 16 90 4.5 17 95 4.75 18 100 5 19 105 5.25 20 110 5.5 21 115 5.75 22 120 6 23 125 6.25 24 130 6.5 25 135 6.75 26 140 7 27 145 7.25 28 150 7.5 29 155 7.75 30 160 8 31 165 8.25 32 170 8.5 33 175 8.75 34 180 9 35 185 9.25 36 190 9.5 37 195 9.75 38 200 10 39 205 10.25 40 210 10.5 41 215 10.75 42 220 11 43 225 11.25 44 230 11.5 45 235 11.75 46 240 12 47 245 12.25 48 250 12.5 49 255 12.75 50 260 13

Example 37 High-Throughput Screening Assay Identifying Changes in Small Molecule Concentration and Membrane Permeability

[1280] Binding of a ligand to a receptor is known to alter intracellular levels of small molecules, such as calcium, potassium, sodium, and pH, as well as alter membrane potential. These alterations can be measured in an assay to identify supernatants which bind to receptors of a particular cell. Although the following protocol describes an assay for calcium, this protocol can easily be modified to detect changes in potassium, sodium, pH, membrane potential, or any other small molecule which is detectable by a fluorescent probe.

[1281] The following assay uses Fluorometric Imaging Plate Reader (“TLIPR”) to measure changes in fluorescent molecules (Molecular Probes) that bind small molecules. Clearly, any fluorescent molecule detecting a small molecule can be used instead of the calcium fluorescent molecule, fluo-4 (Molecular Probes, Inc.; catalog no. F-14202), used here.

[1282] For adherent cells, seed the cells at 10,000-20,000 cells/well in a Co-star black 96-well plate with clear bottom. The plate is incubated in a CO₂ incubator for 20 hours. The adherent cells are washed two times in Biotek washer with 200 ul of HBSS (Hank's Balanced Salt Solution) leaving 100 ul of buffer after the final wash.

[1283] A stock solution of 1 mg/ml fluo-4 is made in 10% pluronic acid DMSO. To load the cells with fluo-4 , 50 ul of 12 ug/ml fluo-4 is added to each well. The plate is incubated at 37 degrees C. in a CO₂ incubator for 60 min. The plate is washed four times in the Biotek washer with HBSS leaving 100 ul of buffer.

[1284] For non-adherent cells, the cells are spun down from culture media. Cells are re-suspended to 2-5×10⁶ cells/ml with HBSS in a 50-ml conical tube. 4 ul of 1 mg/ml fluo-4 solution in 10% pluronic acid DMSO is added to each ml of cell suspension. The tube is then placed in a 37 degrees C. water bath for 30-60 min. The cells are washed twice with HBSS, resuspended to 1×10⁶ cells/ml, and dispensed into a microplate, 100 ul/well. The plate is centrifuged at 1000 rpm for 5 min. The plate is then washed once in Denley Cell Wash with 200 ul, followed by an aspiration step to 100 ul final volume.

[1285] For a non-cell based assay, each well contains a fluorescent molecule, such as fluo-4 . The supernatant is added to the well, and a change in fluorescence is detected.

[1286] To measure the fluorescence of intracellular calcium, the FLIPR is set for the following parameters: (1) System gain is 300-800 mW; (2) Exposure time is 0.4 second; (3) Camera F/stop is F/2; (4) Excitation is 488 nm; (5) Emission is 530 nm; and (6) Sample addition is 50 ul. Increased emission at 530 nm indicates an extracellular signaling event caused by the a molecule, either polypeptide of the present invention or a molecule induced by polypeptide of the present invention, which has resulted in an increase in the intracellular Ca⁺⁺ concentration.

Example 38 High-Throughput Screening Assay Identifying Tyrosine Kinase Activity

[1287] The Protein Tyrosine Kinases (PTK) represent a diverse group of transmembrane and cytoplasmic kinases. Within the Receptor Protein Tyrosine Kinase RPTK) group are receptors for a range of mitogenic and metabolic growth factors including the PDGF, FGF, EGF, NGF, HGF and Insulin receptor subfamilies. In addition there are a large family of RPTKs for which the corresponding ligand is unknown. Ligands for RPTKs include mainly secreted small proteins, but also membrane-bound and extracellular matrix proteins.

[1288] Activation of RPTK by ligands involves ligand-mediated receptor dimerization, resulting in transphosphorylation of the receptor subunits and activation of the cytoplasmic tyrosine kinases. The cytoplasmic tyrosine kinases include receptor associated tyrosine kinases of the src-family (e.g., src, yes, Ick, lyn, fyn) and non-receptor linked and cytosolic protein tyrosine kinases, such as the Jak family, members of which mediate signal transduction triggered by the cytokine superfamily of receptors (e.g., the Interleukins, Interferons, GM-CSF, and Leptin).

[1289] Because of the wide range of known factors capable of stimulating tyrosine kinase activity, identifying whether polypeptide of the present invention or a molecule induced by polypeptide of the present invention is capable of activating tyrosine kinase signal transduction pathways is of interest. Therefore, the following protocol is designed to identify such molecules capable of activating the tyrosine kinase signal transduction pathways.

[1290] Seed target cells (e.g., primary keratinocytes) at a density of approximately 25,000 cells per well in a 96 well Loprodyne Silent Screen Plates purchased from Nalge Nunc (Naperville, Ill.). The plates are sterilized with two 30 minute rinses with 100% ethanol, rinsed with water and dried overnight. Some plates are coated for 2 hr with 100 ml of cell culture grade type I collagen (50 mg/ml), gelatin (2%) or polylysine (50 mg/ml), all of which can be purchased from Sigma Chemicals (St. Louis, MO) or 10% Matrigel purchased from Becton Dickinson (Bedford, Mass.), or calf serum, rinsed with PBS and stored at 4 degree C. Cell growth on these plates is assayed by seeding 5,000 cells/well in growth medium and indirect quantitation of cell number through use of alamarBlue as described by the manufacturer Alamar Biosciences, Inc. (Sacramento, Calif.) after 48 hr. Falcon plate covers #3071 from Becton Dickinson (Bedford, Mass.) are used to cover the Loprodyne Silent Screen Plates. Falcon Microtest III cell culture plates can also be used in some proliferation experiments.

[1291] To prepare extracts, A431 cells are seeded onto the nylon membranes of Loprodyne plates (20,000/200ml/well) and cultured overnight in complete medium. Cells are quiesced by incubation in serum-free basal medium for 24 hr. After 5-20 minutes treatment with EGF (60ng/ml) or 50 ul of the supernatant produced in Example 30, the medium was removed and 100 ml of extraction buffer ((20 mM HEPES pH 7.5, 0.15 M NaCl, 1% Triton X-100, 0.1% SDS, 2 mM Na3VO4, 2 mM Na4P207 and a cocktail of protease inhibitors (# 1836170) obtained from Boeheringer Mannheim (Indianapolis, Ind.)) is added to each well and the plate is shaken on a rotating shaker for 5 minutes at 4° C. The plate is then placed in a vacuum transfer manifold and the extract filtered through the 0.45 mm membrane bottoms of each well using house vacuum. Extracts are collected in a 96-well catch/assay plate in the bottom of the vacuum manifold and immediately placed on ice. To obtain extracts clarified by centrifugation, the content of each well, after detergent solubilization for 5 minutes, is removed and centrifuged for 15 minutes at 4 degree C. at 16,000×g.

[1292] Test the filtered extracts for levels of tyrosine kinase activity. Although many methods of detecting tyrosine kinase activity are known, one method is described here.

[1293] Generally, the tyrosine kinase activity of a supernatant is evaluated by determining its ability to phosphorylate a tyrosine residue on a specific substrate (a biotinylated peptide). Biotinylated peptides that can be used for this purpose include PSK1 (corresponding to amino acids 6-20 of the cell division kinase cdc2-p34) and PSK2 (corresponding to amino acids 1-17 of gastrin). Both peptides are substrates for a range of tyrosine kinases and are available from Boehringer Mannheim.

[1294] The tyrosine kinase reaction is set up by adding the following components in order. First, add 10 ul of 5uM Biotinylated Peptide, then 10 ul ATP/Mg₂₊(5mM ATP/50mM MgCl₂), then 10 ul of 5×Assay Buffer (40 mM imidazole hydrochloride, pH7.3, 40 mM beta-glycerophosphate, 1 mM EGTA, 100 mM MgCl₂, 5 mM MnCl₂, 0.5 mg/ml BSA), then 5 ul of Sodium Vanadate (1 mM), and then 5 ul of water. Mix the components gently and preincubate the reaction mix at 30 degree C. for 2 min. Initial the reaction by adding 10 ul of the control enzyme or the filtered supernatant.

[1295] The tyrosine kinase assay reaction is then terminated by adding 10 ul of 120 mm EDTA and place the reactions on ice.

[1296] Tyrosine kinase activity is determined by transferring 50 ul aliquot of reaction mixture to a microtiter plate (MTP) module and incubating at 37 degree C. for 20 min. This allows the streptavidin coated 96 well plate to associate with the biotinylated peptide. Wash the MTP module with 300 ul/well of PBS four times. Next add 75 ul of anti-phospotyrosine antibody conjugated to horse radish peroxidase (anti-P-Tyr-POD(0.5u/ml)) to each well and incubate at 37 degree C. for one hour. Wash the well as above.

[1297] Next add 100 ul of peroxidase substrate solution (Boehringer Mannheim) and incubate at room temperature for at least 5 mins (up to 30 min). Measure the absorbance of the sample at 405 nm by using ELISA reader. The level of bound peroxidase activity is quantitated using an ELISA reader and reflects the level of tyrosine kinase activity.

Example 39 High-Throughput Screening Assay Identifying Phosphorylation Activity

[1298] As a potential alternative and/or complement to the assay of protein tyrosine kinase activity described in Example 38, an assay which detects activation (phosphorylation) of major intracellular signal transduction intermediates can also be used. For example, as described below one particular assay can detect tyrosine phosphorylation of the Erk-1 and Erk-2 kinases. However, phosphorylation of other molecules, such as Raf, JNK, p38 MAP, Map kinase kinase (MEK), MEK kinase, Src, Muscle specific kinase (MuSK), IRAK, Tec, and Janus, as well as any other phosphoserine, phosphotyrosine, or phosphothreonine molecule, can be detected by substituting these molecules for Erk-1 or Erk-2 in the following assay.

[1299] Specifically, assay plates are made by coating the wells of a 96-well ELISA plate with 0.1 ml of protein G (1 ug/ml) for 2 hr at room temp, (RT). The plates are then rinsed with PBS and blocked with 3% BSA/PBS for 1 hr at RT. The protein G plates are then treated with 2 commercial monoclonal antibodies (100ng/well) against Erk-1 and Erk-2 (1 hr at RT) (Santa Cruz Biotechnology). (To detect other molecules, this step can easily be modified by substituting a monoclonal antibody detecting any of the above described molecules.) After 3-5 rinses with PBS, the plates are stored at 4 degree C. until use.

[1300] A431 cells are seeded at 20,000/well in a 96-well Loprodyne filterplate and cultured overnight in growth medium. The cells are then starved for 48 hr in basal medium (DMEM) and then treated with EGF (6 ng/well) or 50 ul of the supernatants obtained in Example 30 for 5-20 minutes. The cells are then solubilized and extracts filtered directly into the assay plate.

[1301] After incubation with the extract for 1 hr at RT, the wells are again rinsed. As a positive control, a commercial preparation of MAP kinase (10 ng/well) is used in place of A431 extract. Plates are then treated with a commercial polyclonal (rabbit) antibody (lug/ml) which specifically recognizes the phosphorylated epitope of the Erk-1 and Erk-2 kinases (1 hr at RT). This antibody is biotinylated by standard procedures. The bound polyclonal antibody is then quantitated by successive incubations with Europium-streptavidin and Europium fluorescence enhancing reagent in the Wallac DELFIA instrument (time-resolved fluorescence). An increased fluorescent signal over background indicates a phosphorylation by polypeptide of the present invention or a molecule induced by polypeptide of the present invention.

Example 40 Assay for the Stimulation of Bone Marrow CD34+Cell Proliferation

[1302] This assay is based on the ability of human CD34+to proliferate in the presence of hematopoietic growth factors and evaluates the ability of isolated polypeptides expressed in mammalian cells to stimulate proliferation of CD34+cells.

[1303] It has been previously shown that most mature precursors will respond to only a single signal. More immature precursors require at least two signals to respond. Therefore, to test the effect of polypeptides on hematopoietic activity of a wide range of progenitor cells, the assay contains a given polypeptide in the presence or absence of other hematopoietic growth factors. Isolated cells are cultured for 5 days in the presence of Stem Cell Factor (SCF) in combination with tested sample. SCF alone has a very limited effect on the proliferation of bone marrow (BM) cells, acting in such conditions only as a “survival” factor. However, combined with any factor exhibiting stimulatory effect on these cells (e.g., IL-3), SCF will cause a synergistic effect. Therefore, if the tested polypeptide has a stimulatory effect on hematopoietic progenitors, such activity can be easily detected. Since normal BM cells have a low level of cycling cells, it is likely that any inhibitory effect of a given polypeptide, or agonists or antagonists thereof, might not be detected. Accordingly, assays for an inhibitory effect on progenitors is preferably tested in cells that are first subjected to in vitro stimulation with SCF+IL+3, and then contacted with the compound that is being evaluated for inhibition of such induced proliferation.

[1304] Briefly, CD34+cells are isolated using methods known in the art. The cells are thawed and resuspended in medium (QBSF 60 serum-free medium with 1% L-glutamine (500 ml) Quality Biological, Inc., Gaithersburg, Md. Cat# 160-204-101). After several gentle centrifugation steps at 200×g, cells are allowed to rest for one hour. The cell count is adjusted to 2.5×10⁵ cells/ml. During this time, 100 μl of sterile water is added to the peripheral wells of a 96-well plate. The cytokines that can be tested with a given polypeptide in this assay is rhSCF (R&D Systems, Minneapolis, Minn., Cat# 255-SC) at 50 ng/ml alone and in combination with rhSCF and rhIL-3 (R&D Systems, Minneapolis, Minn., Cat# 203-ML) at 30 ng/ml. After one hour, 10 μl of prepared cytokines, 50 μl of the supernatants prepared in Example 30 (supernatants at 1:2 dilution=50 μl) and 20 μl of diluted cells are added to the media which is already present in the wells to allow for a final total volume of 100 μl. The plates are then placed in a 37° C./5% CO₂ incubator for five days.

[1305] Eighteen hours before the assay is harvested, 0.5 μCi/well of [3H] Thymidine is added in a 10 μl volume to each well to determine the proliferation rate. The experiment is terminated by harvesting the cells from each 96-well plate to a filtermat using the Tomtec Harvester 96. After harvesting, the filtermats are dried, trimmed and placed into OmniFilter assemblies consisting of one OmniFilter plate and one OmniFilter Tray. 60 μl Microscint is added to each well and the plate sealed with TopSeal-A press-on sealing film A bar code 15 sticker is affixed to the first plate for counting. The sealed plates are then loaded and the level of radioactivity determined via the Packard Top Count and the printed data collected for analysis. The level of radioactivity reflects the amount of cell proliferation.

[1306] The studies described in this example test the activity of a given polypeptide to stimulate bone marrow CD34+cell proliferation. One skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides (e.g., gene therapy), antibodies, agonists, and/or antagonists and fragments and variants thereof. As a nonlimiting example, potential antagonists tested in this assay would be expected to inhibit cell proliferation in the presence of cytokines and/or to increase the inhibition of cell proliferation in the presence of cytokines and a given polypeptide. In contrast, potential agonists tested in this assay would be expected to enhance cell proliferation and/or to decrease the inhibition of cell proliferation in the presence of cytokines and a given polypeptide.

[1307] The ability of a gene to stimulate the proliferation of bone marrow CD34+cells indicates that polynucleotides and polypeptides corresponding to the gene are useful for the diagnosis and treatment of disorders affecting the immune system and hematopoiesis. Representative uses are described in the “Immune Activity” and “Infectious Disease” sections above, and elsewhere herein.

Example 41 Assay for Extracellular Matrix Enhanced Cell Response (EMECR)

[1308] The objective of the Extracellular Matrix Enhanced Cell Response (EMECR) assay is to identify gene products (e.g., isolated polypeptides) that act on the hematopoietic stem cells in the context of the extracellular matrix (ECM) induced signal.

[1309] Cells respond to the regulatory factors in the context of signal(s) received from the surrounding microenviromnent. For example, fibroblasts, and endothelial and epithelial stem cells fail to replicate in the absence of signals from the ECM. Hematopoietic stem cells can undergo self-renewal in the bone marrow, but not in in vitro suspension culture. The ability of stem cells to undergo self-renewal in vitro is dependent upon their interaction with the stromal cells and the ECM protein fibronectin (fn). Adhesion of cells to fn is mediated by the α₅-β₁ and α₄-β₁ integrin receptors, which are expressed by human and mouse hematopoietic stem cells. The factor(s) which integrate with the ECM environment and are responsible for stimulating stem cell self-renewal have not yet been identified. Discovery of such factors should be of great interest in gene therapy and bone marrow transplant applications

[1310] Briefly, polystyrene, non tissue culture treated, 96-well plates are coated with fn fragment at a coating concentration of 0.2 μg/cm². Mouse bone marrow cells are plated (1,000 cells/well ) in 0.2 ml of serum-free medium. Cells cultured in the presence of IL-3 (5 ng/ml ) +SCF (50 ng/ml ) would serve as the positive control, conditions under which little self-renewal but pronounced differentiation of the stem cells is to be expected. Gene products of the invention (e.g., including, but not limited to, polynucleotides and polypeptides of the present invention, and supernatants produced in Example 30), are tested with appropriate negative controls in the presence and absence of SCF(5.0 ng/ml), where test factor supernatants represent 10% of the total assay volume. The plated cells are then allowed to grow by incubating in a low oxygen environment (5% CO₂, 7% O₂, and 88% N₂) tissue culture incubator for 7 days. The number of proliferating cells within the wells is then quantitated by measuring thymidine incorporation into cellular DNA. Verification of the positive hits in the assay will require phenotypic characterization of the cells, which can be accomplished by scaling up of the culture system and using appropriate antibody reagents against cell surface antigens and FACScan.

[1311] One skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides (e.g., gene therapy), antibodies, agonists, and/or antagonists and fragments and variants thereof.

[1312] If a particular polypeptide of the present invention is found to be a stimulator of hematopoietic progenitors, polynucleotides and polypeptides corresponding to the gene encoding said polypeptide may be useful for the diagnosis and treatment of disorders affecting the immune system and hematopoiesis. Representative uses are described in the “Immune Activity” and “Infectious Disease” sections above, and elsewhere herein. The gene product may also be useful in the expansion of stem cells and committed progenitors of various blood lineages, and in the differentiation and/or proliferation of various cell types.

[1313] Additionally, the polynucleotides and/or polypeptides of the gene of interest and/or agonists and/or antagonists thereof, may also be employed to inhibit the proliferation and differentiation of hematopoletic cells and therefore may be employed to protect bone marrow stem cells from chemotherapeutic agents during chemotherapy. This antiproliferative effect may allow administration of higher doses of chemotherapeutic agents and, therefore, more effective chemotherapeutic treatment.

[1314] Moreover, polynucleotides and polypeptides corresponding to the gene of interest may also be useful for the treatment and diagnosis of hematopoietic related disorders such as, for example, anemia, pancytopenia, leukopenia, thrombocytopenia or leukemia since stromal cells are important in the production of cells of hematopoietic lineages. The uses include bone marrow cell ex-vivo culture, bone marrow transplantation, bone marrow reconstitution, radiotherapy or chemotherapy of neoplasia.

Example 42 Human Dermal Fibroblast and Aortic Smooth Muscle Cell Proliferation

[1315] The polypeptide of interest is added to cultures of normal human dermal fibroblasts (NHDF) and human aortic smooth muscle cells (AoSMC) and two co-assays are performed with each sample. The first assay examines the effect of the polypeptide of interest on the proliferation of normal human dermal fibroblasts (NHDF) or aortic smooth muscle cells (AoSMC). Aberrant growth of fibroblasts or smooth muscle cells is a part of several pathological processes, including fibrosis, and restenosis. The second assay examines IL6 production by both NHDF and SMC. IL6 production is an indication of functional activation. Activated cells will have increased production of a number of cytokines and other factors, which can result in a proinflammatory or immunomodulatory outcome. Assays are run with and without co-TNFa stimulation, in order to check for costimulatory or inhibitory activity.

[1316] Briefly, on day 1, 96-well black plates are set up with 1000 cells/well (NHDF) or 2000 cells/well (AoSMC) in 100 μl culture media. NHDF culture media contains: Clonetics FB basal media, 1 mg/ml hFGF, 5 mg/ml insulin, 50 mg/ml gentamycin, 2% FBS, while AoSMC culture media contains Clonetics SM basal media, 0.5 μg/ml hEGF, 5 mg/ml insulin, 1 μg/ml hFGF, 50 mg/ml gentamycin, 50 μg/ml Amphotericin B, 5% FBS. After incubation at 37° C. for at least 4-5 hours culture media is aspirated and replaced with growth arrest media. Growth arrest media for NHDF contains fibroblast basal media, 50 mg/ml gentamycin, 2% FBS, while growth arrest media for AoSMC contains SM basal media, 50 mg/ml gentamycin, 50 μg/ml Amphotericin B, 0.4% FBS. Incubate at 37° C. until day 2.

[1317] On day 2, serial dilutions and templates of the polypeptide of interest are designed such that they always include media controls and known-protein controls. For both stimulation and inhibition experiments, proteins are diluted in growth arrest media. For inhibition experiments, TNFa is added to a final concentration of 2 ng/ml (NHDF) or 5 ng/ml (AoSMC). Add ⅓ vol media containing controls or polypeptides of the present invention and incubate at 37 degrees C./5% CO₂ until day 5.

[1318] Transfer 60μl from each well to another labeled 96-well plate, cover with a plate-sealer, and store at 4 degrees C. until Day 6 (for IL6 ELISA). To the remaining 100 μl in the cell culture plate, aseptically add Alamar Blue in an amount equal to 10% of the culture volume (10μl). Return plates to incubator for 3 to 4 hours. Then measure fluorescence with excitation at 530 nm and emission at 590 nm using the CytoFluor. This yields the growth stimulation/inhibition data.

[1319] On day 5, the IL6 ELISA is performed by coating a 96 well plate with 50-100 ul/well of Anti-Human IL6 Monoclonal antibody diluted in PBS, pH 7.4, incubate ON at room temperature.

[1320] On day 6, empty the plates into the sink and blot on paper towels. Prepare Assay Buffer containing PBS with 4% BSA. Block the plates with 200 μl/well of Pierce Super Block blocking buffer in PBS for 1-2 hr and then wash plates with wash buffer (PBS, 0.05% Tween-20). Blot plates on paper towels. Then add 50 μl/well of diluted Anti-Human IL-6 Monoclonal, Biotin-labeled antibody at 0.50 mg/ml. Make dilutions of IL-6 stock in media (30, 10, 3, 1, 0.3, 0 ng/ml). Add duplicate samples to top row of plate. Cover the plates and incubate for 2 hours at RT on shaker.

[1321] Plates are washed with wash buffer and blotted on paper towels. Dilute EU-labeled Streptavidin 1:1000 in Assay buffer, and add 100 μl/well. Cover the plate and incubate 1 h at RT. Plates are again washed with wash buffer and blotted on paper towels.

[1322] Add 100 μl/well of Enhancement Solution. Shake for 5 minutes. Read the plate on the Wallac DELFIA Fluorometer. Readings from triplicate samples in each assay were tabulated and averaged.

[1323] A positive result in this assay suggests AoSMC cell proliferation and that the polypeptide of the present invention may be involved in dermal fibroblast proliferation and/or smooth muscle cell proliferation. A positive result also suggests many potential uses of polypeptides, polynucleotides, agonists and/or antagonists of the polynucleotide/polypeptide of the present invention which gives a positive result. For example, inflammation and immune responses, wound healing, and angiogenesis, as detailed throughout this specification. Particularly, polypeptides of the present invention and polynucleotides of the present invention may be used in wound healing and dermal regeneration, as well as the promotion of vasculogenesis, both of the blood vessels and lymphatics. The growth of vessels can be used in the treatment of, for example, cardiovascular diseases. Additionally, antagonists of polypeptides and polynucleotides of the invention may be useful in treating diseases, disorders, and/or conditions which involve angiogenesis by acting as an anti-vascular agent (e.g., anti-angiogenesis). These diseases, disorders, and/or conditions are known in the art and/or are described herein, such as, for example, malignancies, solid tumors, benign tumors, for example hemangiomas, acoustic neuromas, neurofibromas, trachomas, and pyogenic granulomas; artheroscleric plaques; ocular angiogenic diseases, for example, diabetic retinopathy, retinopathy of prematurity, macular degeneration, corneal graft rejection, neovascular glaucoma, retrolental fibroplasia, rubeosis, retinoblastoma, uvietis and Pterygia (abnormal blood vessel growth) of the eye; rheumatoid arthritis; psoriasis; delayed wound healing; endometriosis; vasculogenesis; granulations; hypertrophic scars (keloids); nonunion fractures; scleroderma; trachoma; vascular adhesions; myocardial angiogenesis; coronary collaterals; cerebral collaterals; arteriovenous malformations; ischemic limb angiogenesis; Osler-Webber Syndrome; plaque neovascularization; telangiectasia; hemophiliac joints; angiofibroma; fibromuscular dysplasia; wound granulation; Crohn's disease; and atherosclerosis. Moreover, antagonists of polypeptides and polynucleotides of the invention may be useful in treating anti-hyperproliferative diseases and/or anti-inflammatory known in the art and/or described herein.

[1324] One skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides (e.g., gene therapy), antibodies, agonists, and/or antagonists and fragments and variants thereof.

Example 43 Cellular Adhesion Molecule (CAM) Expression on Endothelial Cells

[1325] The recruitment of lymphocytes to areas of inflammation and angiogenesis involves specific receptor-ligand interactions between cell surface adhesion molecules (CAMs) on lymphocytes and the vascular endothelium. The adhesion process, in both normal and pathological settings, follows a multi-step cascade that involves intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule-1 (E-selectin) expression on endothelial cells (EC). The expression of these molecules and others on the vascular endothelium determines the efficiency with which leukocytes may adhere to the local vasculature and extravasate into the local tissue during the development of an inflammatory response. The local concentration of cytokines and growth factor participate in the modulation of the expression of these CAMs.

[1326] Briefly, endothelial cells (e.g., Human Umbilical Vein Endothelial cells (HUVECs)) are grown in a standard 96 well plate to confluence, growth medium is removed from the cells and replaced with 100 μl of 199 Medium (10% fetal bovine serum (FBS)). Samples for testing and positive or negative controls are added to the plate in triplicate (in 10 μl volumes). Plates are then incubated at 37° C. for either 5 h (selectin and integrin expression) or 24 h (integrin expression only). Plates are aspirated to remove medium and 100 μl of 0.1% paraformaldehyde-PBS(with Ca++and Mg++) is added to each well. Plates are held at 4° C. for 30 min. Fixative is removed from the wells and wells are washed 1× with PBS(+Ca,Mg)+0.5% BSA and drained. 10 μl of diluted primary antibody is added to the test and control wells. Anti-ICAM-1-Biotin, Anti-VCAM-1-Biotin and Anti-E-selectin-Biotin are used at a concentration of 10 μg/ml (1:10 dilution of 0.1 mg/ml stock antibody). Cells are incubated at 37° C. for 30 min. in a humidified environment. Wells are washed three times with PBS(+Ca,Mg)+0.5% BSA. 20 μl of diluted ExtrAvidin-Alkaline Phosphatase (1:5,000 dilution, referred to herein as the working dilution) are added to each well and incubated at 37° C. for 30 min. Wells are washed three times with PBS(+Ca,Mg)+0.5% BSA. Dissolve 1 tablet of p-Nitrophenol Phosphate pNPP per 5 ml of glycine buffer (pH 10.4). 100 μl of pNPP substrate in glycine buffer is added to each test well. Standard wells in triplicate are prepared from the working dilution of the ExtrAvidin-Alkaline Phosphotase in glycine buffer: 1:5,000 (10⁰)>10^(−0.5)>10⁻¹>10^(−1.5).5 μl of each dilution is added to triplicate wells and the resulting AP content in each well is 5.50 ng, 1.74 ng, 0.55 ng, 0.18 ng. 100 μl of pNNP reagent is then added to each of the standard wells. The plate is incubated at 37° C. for 4 h. A volume of 50 μl of 3M NaOH is added to all wells. The plate is read on a plate reader at 405 nm using the background subtraction option on blank wells filled with glycine buffer only. Additionally, the template is set up to indicate the concentration of AP-conjugate in each standard well [5.50 ng; 1.74 ng; 0.55 ng; 0.18 ng]. Results are indicated as amount of bound AP-conjugate in each sample.

Example 44 Alamar Blue Endothelial Cells Proliferation Assay

[1327] This assay may be used to quantitatively determine protein mediated inhibition of bFGF-induced proliferation of Bovine Lymphatic Endothelial Cells (LECs), Bovine Aortic Endothelial Cells (BAECs) or Human Microvascular Uterine Myometrial Cells (UTMECs). This assay incorporates a fluorometric growth indicator based on detection of metabolic activity. A standard Alamar Blue Proliferation Assay is prepared in EGM-2MV with 10 ng /ml of bFGF added as a source of endothelial cell stimulation. This assay may be used with a variety of endothelial cells with slight changes in growth medium and cell concentration. Dilutions of the protein batches to be tested are diluted as appropriate. Serum-free medium (GIBCO SFM) without bFGF is used as a non-stimulated control and Angiostatin or TSP-1 are included as a known inhibitory controls.

[1328] Briefly, LEC, BAECs or UTMECs are seeded in growth media at a density of 5000 to 2000 cells/well in a 96 well plate and placed at 37 degrees C. overnight. After the overnight incubation of the cells, the growth media is removed and replaced with GIBCO EC-SFM. The cells are treated with the appropriate dilutions of the protein of interest or control protein sample(s) (prepared in SFM ) in triplicate wells with additional bFGF to a concentration of 10 ng/ ml. Once the cells have been treated with the samples, the plate(s) is/are placed back in the 37° C. incubator for three days. After three days 10 ml of stock alamar blue (Biosource Cat# DAL1100) is added to each well and the plate(s) is/are placed back in the 37° C. incubator for four hours. The plate(s) are then read at 530 nm excitation and 590 nm emission using the CytoFluor fluorescence reader. Direct output is recorded in relative fluorescence units.

[1329] Alamar blue is an oxidation-reduction indicator that both fluoresces and changes color in response to chemical reduction of growth medium resulting from cell growth. As cells grow in culture, innate metabolic activity results in a chemical reduction of the immediate surrounding environment. Reduction related to growth causes the indicator to change from oxidized (non-fluorescent blue) form to reduced (fluorescent red) form (i.e., stimulated proliferation will produce a stronger signal and inhibited proliferation will produce a weaker signal and the total signal is proportional to the total number of cells as well as their metabolic activity). The background level of activity is observed with the starvation medium alone. This is compared to the output observed from the positive control samples (bFGF in growth medium) and protein dilutions.

Example 45 Detection of Inhibition of a Mixed Lymphocyte Reaction

[1330] This assay can be used to detect and evaluate inhibition of a Mixed Lymphocyte Reaction (MLR) by gene products (e.g., isolated polypeptides). Inhibition of a MLR may be due to a direct effect on cell proliferation and viability, modulation of costimulatory molecules on interacting cells, modulation of adhesiveness between lymphocytes and accessory cells, or modulation of cytokine production by accessory cells. Multiple cells may be targeted by these polypeptides since the peripheral blood mononuclear fraction used in this assay includes T, B and natural killer lymphocytes, as well as monocytes and dendritic cells.

[1331] Polypeptides of interest found to inhibit the MLR may find application in diseases associated with lymphocyte and monocyte activation or proliferation. These include, but are not limited to, diseases such as asthma, arthritis, diabetes, inflammatory skin conditions, psoriasis, eczema, systemic lupus erythematosus, multiple sclerosis, glomerulonephritis, inflammatory bowel disease, crohn's disease, ulcerative colitis, arteriosclerosis, cirrhosis, graft vs. host disease, host vs. graft disease, hepatitis, leukemia and lymphoma.

[1332] Briefly, PBMCs from human donors are purified by density gradient centrifugation using Lymphocyte Separation Medium (LSM®, density 1.0770 g/ml, Organon Teknika Corporation, West Chester, PA). PBMCs from two donors are adjusted to 2×10⁶ cells/ml in RPMI-1640 (Life Technologies, Grand Island, N.Y.) supplemented with 10% FCS and 2 mM glutamine. PBMCs from a third donor is adjusted to 2×10⁵cells/ml. Fifty microliters of PBMCs from each donor is added to wells of a 96-well round bottom microtiter plate. Dilutions of test materials (50 μl) is added in triplicate to microtiter wells. Test samples (of the protein of interest) are added for final dilution of 1:4; rhuIL-2 (R&D Systems, Minneapolis, Minn., catalog number 202-IL) is added to a final concentration of 1 μg/ml; anti-CD4 mAb (R&D Systems, clone 34930.11, catalog number MAB379) is added to a final concentration of 10 μg/ml. Cells are cultured for 7-8 days at 37° C. in 5% CO₂, and 1 μC of [³H] thymidine is added to wells for the last 16 hrs of culture. Cells are harvested and thymidine incorporation determined using a Packard TopCount. Data is expressed as the mean and standard deviation of triplicate determinations.

[1333] Samples of the protein of interest are screened in separate experiments and compared to the negative control treatment, anti-CD4 mAb, which inhibits proliferation of lymphocytes and the positive control treatment, IL-2 (either as recombinant material or supernatant), which enhances proliferation of lymphocytes.

[1334] One skilled in the art could easily modify the exemplified studies to test the activity of polynucleotides (e.g., gene therapy), antibodies, agonists, and/or antagonists and fragments and variants thereof.

Example 46 Assays for Protease Activity

[1335] The following assay may be used to assess protease activity of the polypeptides of the invention.

[1336] Gelatin and casein zymography are performed essentially as described (Heusen et al., Anal. Biochem., 102:196-202 (1980); Wilson et al., Journal of Urology, 149:653-658 (1993)). Samples are run on 10% polyacryamide/0.1% SDS gels containing 1% gelain orcasein, soaked in 2.5% triton at room temperature for 1 hour, and in 0.1M glycine, pH 8.3 at 37° C. 5 to 16 hours. After staining in amido black areas of proteolysis apear as clear areas agains the blue-black background. Trypsin (Sigma T8642) is used as a positive control.

[1337] Protease activity is also determined by monitoring the cleavage of n-a-benzoyl-L-arginine ethyl ester (BAEE) (Sigma B-4500. Reactions are set up in (25 mMNaPO₄, 1 mM EDTA, and 1 mM BAEE), pH 7.5. Samples are added and the change in adsorbance at 260 nm is monitored on the Beckman DU-6 spectrophotometer in the time-drive mode. Trypsin is used as a positive control.

[1338] Additional assays based upon the release of acid-soluble peptides from casein or hemoglobin measured as adsorbance at 280 nm or colorimetrically using the Folin method are performed as described in Bergmeyer, et al., Methods of Enzymatic Analysis, 5 (1984). Other assays involve the solubilization of chromogenic substrates (Ward, Applied Science, 251-317 (1983).

Example 47 Identifying Serine Protease Substrate Specificity

[1339] Methods known in the art or described herein may be used to determine the substrate specificity of the polypeptides of the present invention having serine protease activity. A preferred method of determining substrate specificity is by the use of positional scanning synthetic combinatorial libraries as described in GB 2 324 529 (incorporated herein in its entirety).

Example 48 Ligand Binding Assays

[1340] The following assay may be used to assess ligand binding activity of the polypeptides of the invention.

[1341] Ligand binding assays provide a direct method for ascertaining receptor pharmacology and are adaptable to a high throughput format. The purified ligand for a polypeptide is radiolabeled to high specific activity (50-2000 Ci/mmol) for binding studies. A determination is then made that the process of radiolabeling does not diminish the activity of the ligand towards its polypeptide. Assay conditions for buffers, ions, pH and other modulators such as nucleotides are optimized to establish a workable signal to noise ratio for both membrane and whole cell polypeptide sources.

[1342] For these assays, specific polypeptide binding is defined as total associated radioactivity minus the radioactivity measured in the presence of an excess of unlabeled competing ligand. Where possible, more than one competing ligand is used to define residual nonspecific binding.

Example 49 Functional Assay in Xenopus Oocytes

[1343] Capped RNA transcripts from linearized plasmid templates encoding the polypeptides of the invention are synthesized in vitro with RNA polymerases in accordance with standard procedures. In vitro transcripts are suspended in water at a final concentration of 0.2 mg/mi. Ovarian lobes are removed from adult female toads, Stage V defolliculated oocytes are obtained, and RNA transcripts (10 ng/oocytc) are injected in a 50 nl bolus using a microinjection apparatus. Two electrode voltage clamps are used to measure the currents from individual Xenopus oocytes in response polypeptides and polypeptide agonist exposure. Recordings are made in Ca2+ free Barth's medium at room temperature. The Xenopus system can be used to screen known ligands and tissue/cell extracts for activating ligands.

Example 50 Microphysiometric Assays

[1344] Activation of a wide variety of secondary messenger systems results in extrusion of small amounts of acid from a cell. The acid formed is largely as a result of the increased metabolic activity required to fuel the intracellular signaling process. The pH changes in the media surrounding the cell are very small but are detectable by the CYTOSENSOR microphysiometer (Molecular Devices Ltd., Menlo Park, Calif.). The CYTOSENSOR is thus capable of detecting the activation of polypeptide which is coupled to an energy utilizing intracellular signaling pathway.

Example 51 Extract/Cell Supernatant Screening

[1345] A large number of mammalian receptors exist for which there remains, as yet, no cognate activating ligand (agonist). Thus, active ligands for these receptors may not be included within the ligands banks as identified to date. Accordingly, the polypeptides of the invention can also be functionally screened (using calcium, cAMP, microphysiometer, oocyte electrophysiology, etc., functional screens) against tissue extracts to identify its natural ligands. Extracts that produce positive functional responses can be sequentially subfractionated until an activating ligand is isolated and identified.

Example 52 Calcium and cAMP Functional Assays

[1346] Seven transmembrane receptors which are expressed in HEK 293 cells have been shown to be coupled functionally to activation of PLC and calcium mobilization and/or cAMP stimulation or inhibition. Basal calcium levels in the HEK 293 cells in receptor-transfected or vector control cells were observed to be in the normal, 100 nM to 200 nM, range. HEK 293 cells expressing recombinant receptors are loaded with fura 2 and in a single day >150 selected ligands or tissue/cell extracts are evaluated for agonist induced calcium mobilization. Similarly, HEK 293 cells expressing recombinant receptors are evaluated for the stimulation or inhibition of cAMP production using standard cAMP quantitation assays. Agonists presenting a calcium transient or cAMP fluctuation are tested in vector control cells to determine if the response is unique to the transfected cells expressing receptor.

Example 53 ATP-binding Assay

[1347] The following assay may be used to assess ATP-binding activity of polypeptides of the invention.

[1348] ATP-binding activity of the polypeptides of the invention may be detected using the ATP-binding assay described in U.S. Pat. No. 5,858,719, which is herein incorporated by reference in its entirety. Briefly, ATP-binding to polypeptides of the invention is measured via photoaffinity labeling with 8-azido-ATP in a competition assay. Reaction mixtures containing 1 mg/ml of the ABC transport protein of the present invention are incubated with varying concentrations of ATP, or the non-hydrolyzable ATP analog adenyl-5′-imidodiphosphate for 10 minutes at 4° C. A mixture of 8-azido-ATP (Sigma Chem. Corp., St. Louis, Mo.) plus 8-azido-ATP (32p-ATP) (5 mCi/μmol, ICN, Irvine Calif.) is added to a final concentration of 100 μM and 0.5 ml aliquots are placed in the wells of a porcelain spot plate on ice. The plate is irradiated using a short wave 254 nm UV lamp at a distance of 2.5 cm from the plate for two one-minute intervals with a one-minute cooling interval in between. The reaction is stopped by addition of dithiothreitol to a final concentration of 2mM. The incubations are subjected to SDS-PAGE electrophoresis, dried, and autoradiographed. Protein bands corresponding to the particular polypeptides of the invention are excised, and the radioactivity quantified. A decrease in radioactivity with increasing ATP or adenly-5′-imidodiphosphate provides a measure of ATP affinity to the polypeptides.

Example 54 Small Molecule Screening

[1349] This invention is particularly useful for screening therapeutic compounds by using the polypeptides of the invention, or binding fragments thereof, in any of a variety of drug screening techniques. The polypeptide or fragment employed in such a test may be affixed to a solid support, expressed on a cell surface, free in solution, or located intracellularly. One method of drug screening utilizes eukaryotic or prokaryotic host cells which are stably transformed with recombinant nucleic acids expressing the polypeptide or fragment. Drugs are screened against such transformed cells in competitive binding assays. One may measure, for example, the formulation of complexes between the agent being tested and polypeptide of the invention.

[1350] Thus, the present invention provides methods of screening for drugs or any other agents which affect activities mediated by the polypeptides of the invention. These methods comprise contacting such an agent with a polypeptide of the invention or fragment thereof and assaying for the presence of a complex between the agent and the polypeptide or fragment thereof, by methods well known in the art. In such a competitive binding assay, the agents to screen are typically labeled. Following incubation, free agent is separated from that present in bound form, and the amount of free or uncomplexed label is a measure of the ability of a particular agent to bind to the polypeptides of the invention.

[1351] Another technique for drug screening provides high throughput screening for compounds having suitable binding affinity to the polypeptides of the invention, and is described in great detail in European Patent Application 84/03564, published on Sep. 13, 1984, which is herein incorporated by reference in its entirety. Briefly stated, large numbers of different small molecule test compounds are synthesized on a solid substrate, such as plastic pins or some other surface. The test compounds are reacted with polypeptides of the invention and washed. Bound polypeptides are then detected by methods well known in the art. Purified polypeptides are coated directly onto plates for use in the aforementioned drug screening techniques. In addition, non-neutralizing antibodies may be used to capture the peptide and immobilize it on the solid support.

[1352] This invention also contemplates the use of competitive drug screening assays in which neutralizing antibodies capable of binding polypeptides of the invention specifically compete with a test compound for binding to the polypeptides or fragments thereof. In this manner, the antibodies are used to detect the presence of any peptide which shares one or more antigenic epitopes with a polypeptide of the invention.

Example 55 Phosphorylation Assay

[1353] In order to assay for phosphorylation activity of the polypeptides of the invention, a phosphorylation assay as described in U.S. Pat. No. 5,958,405 (which is herein incorporated by reference) is utilized. Briefly, phosphorylation activity may be measured by phosphorylation of a protein substrate using gamma-labeled ³²P-ATP and quantitation of the incorporated radioactivity using a gamma radioisotope counter. The polypeptides of the invention are incubated with the protein substrate, ³²P-ATP, and a kinase buffer. The ³²p incorporated into the substrate is then separated from free ³²p-ATP by electrophoresis, and the incorporated ³²p is counted and compared to a negative control. Radioactivity counts above the negative control are indicative of phosphorylation activity of the polypeptides of the invention.

Example 56 Detection of Phosphorylation Activity (Activation) of the Polypeptides of the Invention in the Presence of Polypeptide Ligands

[1354] Methods known in the art or described herein may be used to determine the phosphorylation activity of the polypeptides of the invention. A preferred method of determining phosphorylation activity is by the use of the tyrosine phosphorylation assay as described in U.S. Pat. No. 5,817,471 (incorporated herein by reference).

Example 57 Identification Of Signal Transduction Proteins That Interact With Polypeptides Of The Present Invention

[1355] The purified polypeptides of the invention are research tools for the identification, characterization and purification of additional signal transduction pathway proteins or receptor proteins. Briefly, labeled receptor PTK polypeptide is useful as a reagent for the purification of molecules with which it interacts. In one embodiment of affinity purification, receptor PTK polypeptide is covalently coupled to a chromatography column. Cell-free extract derived from putative target cells, such as carcinoma tissues, is passed over the column, and molecules with appropriate affinity bind to the receptor PTK polypeptides, or specific phosphotyrosine-recognition domains thereof. The receptor PTK polypeptide interacting protein-complex is recovered from the column, dissociated, and the recovered molecule subjected to N-terminal protein sequencing. This amino acid sequence is then used to identify the captured molecule or to design degenerate oligonucleotide probes for cloning the relevant gene from an appropriate cDNA library.

Example 58 IL-6 Bioassay

[1356] To test the proliferative effects of the polypeptides of the invention, the IL-6 Bioassay as described by Marz et al. is utilized (Proc. Natl. Acad. Sci., U.S.A., 95:3251-56 (1998), which is herein incorporated by reference). Briefly, IL-6 dependent B9 murine cells are washed three times in IL-6 free medium and plated at a concentration of 5,000 cells per well in 50 μl, and 50 μl of the IL-6-like polypeptide is added. After 68 hrs. at 37° C., the number of viable cells is measured by adding the tetrazolium salt thiazolyl blue (MTT) and incubating for a further 4 hrs. at 37° C. B9 cells are lysed by SDS and optical density is measured at 570 mn. Controls containing IL-6 (positive) and no cytokine (negative) are utilized. Enhanced proliferation in the test sample(s) relative to the negative control is indicative of proliferative effects mediated by polypeptides of the invention.

Example 59 Support of Chicken Embryo Neuron Survival

[1357] To test whether sympathetic neuronal cell viability is supported by polypeptides of the invention, the chicken embryo neuronal survival assay of Senaldi et al is utilized (Proc. Natl. Acad. Sci., U.S.A., 96:11458-63 (1998), which is herein incorporated by reference). Briefly, motor and sympathetic neurons are isolated from chicken embryos, resuspended in L15 medium (with 10% FCS, glucose, sodium selenite, progesterone, conalbumin, putrescine, and insulin; Life Technologies, Rockville, Md.) and Dulbecco's modified Eagles medium [with 10% FCS, glutamine, penicillin, and 25 mM Hepes buffer (pH 7.2); Life Technologies, Rockville, MD.], respectively, and incubated at 37° C. in 5% CO₂ in the presence of different concentrations of the purified IL-6-like polypeptide, as well as a negative control lacking any cytokine. After 3 days, neuron survival is determined by evaluation of cellular morphology, and through the use of the colorimetric assay of Mosmann (Mossman, T., J. Immunol. Methods, 65:55-63 (1983)). Enhanced neuronal cell viability as compared to the controls lacking cytokine is indicative of the ability of the inventive purified IL-6-like polypeptide(s) to enhance the survival of neuronal cells.

Example 60 Assay for Phosphatase Activity

[1358] The following assay may be used to assess serine/threonine phosphatase (PTPase) activity of the polypeptides of the invention.

[1359] In order to assay for serine/threonine phosphatase (PTPase) activity, assays can be utilized which are widely known to those skilled in the art. For example, the serine/threonine phosphatase (PSPase) activity is measured using a PSPase assay kit from New England Biolabs, Inc. Myelin basic protein (MyBP), a substrate for PSPase, is phosphorylated on serine and threonine residues with cAMP-dependent Protein Kinase in the presence of [³²P]ATP. Protein serine/threonine phosphatase activity is then determined by measuring the release of inorganic phosphate from 32P-labeled MyBP.

Example 61 Interaction of Serine/Threonine Phosphatases with other Proteins

[1360] The polypeptides of the invention with serine/threonine phosphatase activity as determined in Example 60 are research tools for the identification, characterization and purification of additional interacting proteins or receptor proteins, or other signal transduction pathway proteins. Briefly, labeled polypeptide(s) of the invention is useful as a reagent for the purification of molecules with which it interacts. In one embodiment of affinity purification, polypeptide of the invention is covalently coupled to a chromatography column. Cell-free extract derived from putative target cells, such as neural or liver cells, is passed over the column, and molecules with appropriate affinity bind to the polypeptides of the invention. The polypeptides of the invention -complex is recovered from the column, dissociated, and the recovered molecule subjected to N-terminal protein sequencing. This amino acid sequence is then used to identify the captured molecule or to design degenerate oligonucleotide probes for cloning the relevant gene from an appropriate cDNA library.

Example 62 Assaying for Heparanase Activity

[1361] In order to assay for heparanase activity of the polypeptides of the invention, the heparanase assay described by Vlodavsky et al is utilized (Vlodavsky, I., et al., Nat. Med., 5:793-802 (1999)). Briefly, cell lysates, conditioned media or intact cells (1×10⁶ cells per 35-mm dish) are incubated for 18 hrs at 37° C., pH 6.2-6.6, with ³⁵S-labeled ECM or soluble ECM derived peak I proteoglycans. The incubation medium is centrifuged and the supernatant is analyzed by gel filtration on a Sepharose CL-6B column (0.9×30 cm). Fractions are eluted with PBS and their radioactivity is measured. Degradation fragments of heparan sulfate side chains are eluted from Sepharose 6B at 0.5 <K_(av)<0.8 (peak II). Each experiment is done at least three times. Degradation fragments corresponding to “peak II,” as described by Vlodavsky et al., is indicative of the activity of the polypeptides of the invention in cleaving heparan sulfate.

Example 63 Immobilization of biomolecules

[1362] This example provides a method for the stabilization of polypeptides of the invention in non-host cell lipid bilayer constucts (see, e.g., Bieri et al., Nature Biotech 17:1105-1108 (1999), hereby incorporated by reference in its entirety herein) which can be adapted for the study of polypeptides of the invention in the various functional assays described above. Briefly, carbohydrate-specific chemistry for biotinylation is used to confine a biotin tag to the extracellular domain of the polypeptides of the invention, thus allowing uniform orientation upon immobilization. A 50 uM solution of polypeptides of the invention in washed membranes is incubated with 20 mM NaIO4 and 1.5 mg/ml (4mM) BACH or 2 mg/ml (7.5mM) biotin-hydrazide for 1 hr at room temperature (reaction volume, 150 ul). Then the sample is dialyzed (Pierce Slidealizer Cassett, 10 kDa cutoff; Pierce Chemical Co., Rockford Ill.) at 4C first for 5 h, exchanging the buffer after each hour, and finally for 12 h against 500 ml buffer R (0.15 M NaCl, 1 mM MgCl2, 10 mM sodium phosphate, pH7). Just before addition into a cuvette, the sample is diluted 1:5 in buffer ROG50 (Buffer R supplemented with 50 mM octylglucoside).

Example 64 TAQMAN

[1363] Quantitative PCR (QPCR). Total RNA from cells in culture are extracted by Trizol separation as recommended by the supplier (LifeTechnologies). (Total RNA is treated with DNase I (Life Technologies) to remove any contaminating genomic DNA before reverse transcription.) Total RNA (50 ng) is used in a one-step, 50 ul, RT-QPCR, consisting of Taqman Buffer A (Perkin-Elmer; 50 mM KCl/10 mM Tris, pH 8.3), 5.5 mM MgCl₂, 240 μM each dNTP, 0.4 units RNase inhibitor(Promega), 8% glycerol, 0.012% Tween-20, 0.05% gelatin, 0.3uM primers, 0.1 uM probe, 0.025 units Amplitaq Gold (Perkin-Elmer) and 2.5 units Superscript II reverse transcriptase (Life Technologies). As a control for genomic contamination, parallel reactions are setup without reverse transcriptase. The relative abundance of (unknown) and 18S RNAs are assessed by using the Applied Biosystems Prism 7700 Sequence Detection System (Livak, K. J., Flood, S. J., Marmaro, J., Giusti, W. & Deetz, K. (1995) PCR Methods Appl. 4, 357-362). Reactions are carried out at 48° C. for 30 min, 95° C. for 10 min, followed by 40 cycles of 95° C. for 15 s, 60° C. for 1 min. Reaction performed in triplicate.

[1364] Primers (f & r) and FRET probes sets are designed using Primer Express Software (Perkin-Elmer). Probes are labeled at the 5′-end with the reporter dye 6-FAM and on the 3′-end with the quencher dye TAMRA (Biosource International, Camarillo, Calif. or Perkin-Elmer).

Example 65 Assays for Metalloproteinase Activity

[1365] Metalloproteinases (EC 3.4.24.-) are peptide hydrolases which use metal ions, such as Zn²⁺, as the catalytic mechanism. Metalloproteinase activity of polypeptides of the present invention can be assayed according to the following methods.

[1366] Proteolysis of alpha-2-macroglobulin

[1367] To confirm protease activity, purified polypeptides of the invention are mixed with the substrate alpha-2-macroglobulin (0.2 unit/ml; Boehringer Mannheim, Germany) in 1×assay buffer (50 mM HEPES, pH 7.5, 0.2 M NaCl, 10 mM CaCl₂, 25 μM ZnCl₂ and 0.05% Brij-35) and incubated at 37° C. for 1-5 days. Trypsin is used as positive control. Negative controls contain only alpha-2-macroglobulin in assay buffer. The samples are collected and boiled in SDS-PAGE sample buffer containing 5% 2-mercaptoethanol for 5-min, then loaded onto 8% SDS-polyacrylamide gel. After electrophoresis the proteins are visualized by silver staining. Proteolysis is evident by the appearance of lower molecular weight bands as compared to the negative control.

[1368] Inhibition of alpha-2-macroglobulin Proteolysis by Inhibitors of Metalloproteinases

[1369] Known metalloproteinase inhibitors (metal chelators (EDTA, EGTA, AND HgCl₂), peptide metalloproteinase inhibitors (TIMP-1 and TIMP-2), and commercial small molecule MMP inhibitors) are used to characterize the proteolytic activity of polypeptides of the invention. The three synthetic MMP inhibitors used are: MMP inhibitor I, [IC₅₀=1.0 μM against MMP-1 and MMP-8; IC₅₀=30 μM against MMP-9; IC₅₀=150 μM against MMP-3]; MMP-3 (stromelysin-1) inhibitor I [IC₅₀=5 μM against MMP-3], and MMP-3 inhibitor II [K_(i)=130 nM against MMP-3]; inhibitors available through Calbiochem, catalog # 444250, 444218, and 444225, respectively). Briefly, different concentrations of the small molecule MMP inhibitors are mixed with purified polypeptides of the invention (50μg/ml) in 22.9 μl of 1×HEPES buffer (50 mM HEPES, pH 7.5, 0.2 M NaCl, 10 mM CaCl₂, 25 μM ZnCl₂ and 0.05% Brij-35) and incubated at room temperature (24° C.) for 2-hr, then 7.1 μl of substrate alpha-2-macroglobulin (0.2 unit/ml) is added and incubated at 37° C. for 20-hr. The reactions are stopped by adding 4×sample buffer and boiled immediately for 5 minutes. After SDS-PAGE, the protein bands are visualized by silver stain.

[1370] Synthetic Fluorogenic Peptide Substrates Cleavage Assay

[1371] The substrate specificity for polypeptides of the invention with demonstrated metalloproteinase activity can be determined using synthetic fluorogenic peptide substrates (purchased from BACHEM Bioscience Inc). Test substrates include, M-1985, M-2225, M-2105, M-2110, and M-2255. The first four are MMP substrates and the last one is a substrate of tumor necrosis factor-α (TNF-α) converting enzyme (TACE). All the substrates are prepared in 1:1 dimethyl sulfoxide (DMSO) and water.

[1372] The stock solutions are 50-500 μM. Fluorescent assays are performed by using a Perkin Elmer LS 50B luminescence spectrometer equipped with a constant temperature water bath. The excitation λ is 328 nm and the emission X is 393 nm.

[1373] Briefly, the assay is carried out by incubating 176 μl 1×HEPES buffer (0.2 M NaCl, 10 mM CaCI₂, 0.05% Brij-35 and 50 mM HEPES, pH 7.5) with 4 μl of substrate solution (50 μM) at 25° C. for 15 minutes, and then adding 20 μl of a purified polypeptide of the invention into the assay cuvett. The final concentration of substrate is 1 μM. Initial hydrolysis rates are monitored for 30-min.

Example 66 Characterization of the cDNA contained in a deposited plasmid

[1374] The size of the cDNA insert contained in a deposited plasmid may be routinely determined using techniques known in the art, such as PCR amplification using synthetic primers hybridizable to the 3′ and 5′ ends of the cDNA sequence. For example, two primers of 17-30 nucleotides derived from each end of the cDNA (i.e., hybridizable to the absolute 5′ nucleotide or the 3′ nucleotide end of the sequence of SEQ ID NO: X, respectively) are synthesized and used to amplify the cDNA using the deposited cDNA plasmid as a template. The polymerase chain reaction is carried out under routine conditions, for instance, in 25 ul of reaction mixture with 0.5 ug of the above cDNA template. A convenient reaction mixture is 1.5-5 mM MgCl₂, 0.01% (w/v) gelatin, 20 uM each of dATP, dCTP, dGTP, dTTP, 25 pmol of each primer and 0.25 Unit of Taq polymerase. Thirty five cycles of PCR (denaturation at 94 degree C. for 1 min; annealing at 55 degree C. for 1 min; elongation at 72 degree C. for 1 min) are performed with a Perkin-Elmer Cetus automated thermal cycler. The amplified product is analyzed by agarose gel electrophoresis. The PCR product is verified to be the selected sequence by subcloning and sequencing the DNA product.

[1375] Use of the above methodologies and/or other methodologies known in the art generates fragments from the clone corresponding to the approximate fragments described in Table 8, below. Accordingly, Table 8 provides a physical characterization of certain clones encompassed by the invention. The first column provides the unique clone identifier, “Clone ID NO: Z”, for cDNA clones of the invention, as described in Table 1A. The second column provides the approximate size of the cDNA insert contained in the corresponding cDNA clone. TABLE 8 cDNA Clone ID Insert NO: Z Size: H7MDD72 700 HBGMZ39 500 HEGAZ61 600 HEPBA39 700 HEPCU32 1500 HLWAR77 1300 HPFDV71 700 HTECA32 800 HTEHC47 700 HTLIV78 700 HTTCT34 600 HUKEP18 900 HTEPE35 700 HPWCG85 1000 HPFCP82 700 HOFMU67 1400 HBZAI39 1100 HBGMG81 700

[1376] It will be clear that the invention may be practiced otherwise than as particularly described in the foregoing description and examples. Numerous modifications and variations of the present invention are possible in light of the above teachings and, therefore, are within the scope of the appended claims.

[1377] The entire disclosure of each document cited (including patents, patent applications, journal articles, abstracts, laboratory manuals, books, or other disclosures) in the Background of the Invention, Detailed Description, and Examples is hereby incorporated herein by reference. In addition, the CD-R copy of the sequence listing submitted herewith and the corresponding computer readable form are both incorporated herein by reference in their entireties. The specification and Sequence Listing of each of the following U.S. applications are herein incorporated by reference in their entirety: application Ser. No. 60/179,065, filed on Jan. 31, 2000; application Ser. No. 60/180,628, filed on Feb. 4, 2000; application Ser. No. 60/214,886, filed on Jun. 28, 2000; application Ser. No. 60/217,487, filed on Jul. 11, 2000; application Ser. No. 60/225,758, filed on Aug. 14, 2000; application Ser. No. 60/220,963, filed on Jul. 26, 2000; application Ser. No. 60/217,496, filed on Jul. 11, 2000; application Ser. No. 60/225,447, filed on Aug. 14, 2000; application Ser. No. 60/218,290, filed on Jul. 14, 2000; application Ser. No. 60/225,757, filed on Aug. 14, 2000; application Ser. No. 60/226,868, filed on Aug. 22, 2000; application Ser. No. 60/216,647, filed on Jul. 7, 2000; application Ser. No. 60/225,267, filed on Aug. 14, 2000; application Ser. No. 60/216,880, filed on Jul. 7, 2000; application Ser. No. 60/225,270, filed on Aug. 14, 2000; application Ser. No. 60/251,869, filed on Dec. 8, 2000; application Ser. No. 60/235,834, filed on Sep. 27, 2000; application Ser. No. 60/234,274, filed on Sep. 21, 2000; application Ser. No. 60/234,223, filed on Sep. 21, 2000; application Ser. No. 60/228,924, filed on Aug. 30, 2000; application Ser. No. 60/224,518, filed on Aug. 14, 2000; application Ser. No. 60/236,369, filed on Sep. 29, 2000; application Ser. No. 60/224,519, filed on Aug. 14, 2000; application Ser. No. 60/220,964, filed on Jul. 26, 2000; application Ser. No. 60/241,809, filed on Oct. 20, 2000; application Ser. No. 60/249,299, filed on Nov. 17, 2000; application Ser. No. 60/236,327, filed on Sep. 29, 2000; application Ser. No. 60/241,785, filed on Oct. 20, 2000; application Ser. No. 60/244,617, filed on Nov. 1, 2000; application Ser. No. 60/225,268, filed on Aug. 14, 2000; application Ser. No. 60/236,368, filed on Sep. 29, 2000; application Ser. No. 60/251,856, filed on Dec. 8, 2000; application Ser. No. 60/251,868, filed on Dec. 8, 2000; application Ser. No. 60/229,344, filed on Sep. 1, 2000; application Ser. No. 60/234,997, filed on Sep. 25, 2000; application Ser. No. 60/229,343, filed on Sep. 1, 2000; application Ser. No. 60/229,345, filed on Sep. 1, 2000; application Ser. No. 60/229,287, filed on Sep. 1, 2000; application Ser. No. 60/229,513, filed on Sep. 5, 2000; application Ser. No. 60/231,413, filed on Sep. 8, 2000; application Ser. No. 60/229,509, filed on Sep. 5, 2000; application Ser. No. 60/236,367, filed on Sep. 29, 2000; application Ser. No. 60/237,039, filed on Oct. 2, 2000; application Ser. No. 60/237,038, filed on Oct. 2, 2000; application Ser. No. 60/236,370, filed on Sep. 29, 2000; application Ser. No. 60/236,802, filed on Oct. 2, 2000; application Ser. No. 60/237,037, filed on Oct. 2, 2000; application Ser. No. 60/237,040, filed on Oct. 2, 2000; application Ser. No. 60/240,960, filed on Oct. 20, 2000; application Ser. No. 60/239,935, filed on Oct. 13, 2000; application Ser. No. 60/239,937, filed on Oct. 13, 2000; application Ser. No. 60/241,787, filed on Oct. 20, 2000; application Ser. No. 60/246,474, filed on Nov. 8, 2000; application Ser. No. 60/246,532, filed on Nov. 8, 2000; application Ser. No. 60/249,216, filed on Nov. 17, 2000; application Ser. No. 60/249,210, filed on Nov. 17, 2000; application Ser. No. 60/226,681, filed on Aug. 22, 2000; application Ser. No. 60/225,759, filed on Aug. 14, 2000; application Ser. No. 60/225,213, filed on Aug. 14, 2000; application Ser. No. 60/227,182, filed on Aug. 22, 2000; application Ser. No. 60/225,214, filed on Aug. 14, 2000; application Ser. No. 60/235,836, filed on Sep. 27, 2000; application Ser. No. 60/230,438, filed on Sep. 6, 2000; application Ser. No. 60/215,135, filed on Jun. 30, 2000; application Ser. No. 60/225,266, filed on Aug. 14, 2000; application Ser. No. 60/249,218, filed on Nov. 17, 2000; application Ser. No. 60/249,208, filed on Nov. 17, 2000; application Ser. No. 60/249,213, filed on Nov. 17, 2000; application Ser. No. 60/249,212, filed on Nov. 17, 2000; application Ser. No. 60/249,207, filed on Nov. 17, 2000; application Ser. No. 60/249,245, filed on Nov. 17, 2000; application Ser. No. 60/249,244, filed on Nov. 17, 2000; application Ser. No. 60/249,217, filed on Nov. 17, 2000; application Ser. No. 60/249,211, filed on Nov. 17, 2000; application Ser. 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[1378] Moreover, the microfiche copy and the corresponding computer readable form of the Sequence Listing of U.S. application Ser. No. 60/179,065, and the hard copy of and the corresponding computer readable form of the Sequence Listing of U.S. application Ser. No. 60/180,628 are also incorporated herein by reference in their entireties.

0 SEQUENCE LISTING The patent application contains a lengthy “Sequence Listing” section. A copy of the “Sequence Listing” is available in electronic form from the USPTO web site (http://seqdata.uspto.gov/sequence.html?DocID=20030077808). An electronic copy of the “Sequence Listing” will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3). 

What is claimed is:
 1. An isolated nucleic acid molecule comprising a polynucleotide having a nucleotide sequence at least 95% identical to a sequence selected from the group consisting of: (a) a polynucleotide fragment of SEQ ID NO: X or a polynucleotide fragment of the cDNA sequence contained in Clone ID NO: Z, which is hybridizable to SEQ ID NO: X; (b) a polynucleotide encoding a polypeptide fragment of SEQ ID NO: Y or a polypeptide fragment encoded by the cDNA sequence contained in cDNA Clone ID NO: Z, which is hybridizable to SEQ ID NO: X; (c) a polynucleotide encoding a polypeptide fragment of a polypeptide encoded by SEQ ID NO: X or a polypeptide fragment encoded by the cDNA sequence contained in cDNA Clone ID NO: Z, which is hybridizable to SEQ ID NO: X; (d) a polynucleotide encoding a polypeptide domain of SEQ ID NO: Y or a polypeptide domain encoded by the cDNA sequence contained in cDNA Clone ID NO: Z, which is hybridizable to SEQ ID NO: X; (e) a polynucleotide encoding a polypeptide epitope of SEQ ID NO: Y or a polypeptide epitope encoded by the cDNA sequence contained in cDNA Clone ID NO: Z, which is hybridizable to SEQ ID NO: X; (f) a polynucleotide encoding a polypeptide of SEQ ID NO: Y or the cDNA sequence contained in cDNA Clone ID NO: Z, which is hybridizable to SEQ ID NO: X, having biological activity; (g) a polynucleotide which is a variant of SEQ ID NO :X; (h) a polynucleotide which is an allelic variant of SEQ ID NO: X; (i) a polynucleotide which encodes a species homologue of the SEQ ID NO: Y; (j) a polynucleotide capable of hybridizing under stringent conditions to any one of the polynucleotides specified in (a)-(i), wherein said polynucleotide does not hybridize under stringent conditions to a nucleic acid molecule having a nucleotide sequence of only A residues or of only T residues.
 2. The isolated nucleic acid molecule of claim 1, wherein the polynucleotide fragment comprises a nucleotide sequence encoding a protein.
 3. The isolated nucleic acid molecule of claim 1, wherein the polynucleotide fragment comprises a nucleotide sequence encoding the sequence identified as SEQ ID NO: Y or the polypeptide encoded by the cDNA sequence contained in cDNA Clone ID NO: Z, which is hybridizable to SEQ ID NO: X.
 4. The isolated nucleic acid molecule of claim 1, wherein the polynucleotide fragment comprises the entire nucleotide sequence of SEQ ID NO: X or the cDNA sequence contained in cDNA Clone ID NO: Z, which is hybridizable to SEQ ID NO: X.
 5. The isolated nucleic acid molecule of claim 2, wherein the nucleotide sequence comprises sequential nucleotide deletions from either the C-terminus or the N-terminus.
 6. The isolated nucleic acid molecule of claim 3, wherein the nucleotide sequence comprises sequential nucleotide deletions from either the C-terminus or the N-terminus.
 7. A recombinant vector comprising the isolated nucleic acid molecule of claim
 1. 8. A method of making a recombinant host cell comprising the isolated nucleic acid molecule of claim
 1. 9. A recombinant host cell produced by the method of claim
 8. 10. The recombinant host cell of claim 9 comprising vector sequences.
 11. An isolated polypeptide comprising an amino acid sequence at least 90% identical to a sequence selected from the group consisting of: (a) a polypeptide fragment of SEQ ID NO: Y or the encoded sequence contained in cDNA Clone ID NO: Z; (b) a polypeptide fragment of SEQ ID NO: Y or the encoded sequence contained in cDNA Clone ID NO: Z, having biological activity; (c) a polypeptide domain of SEQ ID NO: Y or the encoded sequence contained in cDNA Clone ID NO: Z; (d) a polypeptide epitope of SEQ ID NO: Y or the encoded sequence contained in cDNA Clone ID NO: Z; (e) a full length protein of SEQ ID NO: Y or the encoded sequence contained in cDNA Clone ID NO: Z; (f) a variant of SEQ ID NO: Y; (g) an allelic variant of SEQ ID NO: Y; or (h) a species homologue of the SEQ ID NO: Y.
 12. The isolated polypeptide of claim 11, wherein the full length protein comprises sequential amino acid deletions from either the C-terminus or the N-terminus.
 13. An isolated antibody that binds specifically to the isolated polypeptide of claim
 11. 14. A recombinant host cell that expresses the isolated polypeptide of claim
 11. 15. A method of making an isolated polypeptide comprising: (a) culturing the recombinant host cell of claim 14 under conditions such that said polypeptide is expressed; and (b) recovering said polypeptide.
 16. The polypeptide produced by claim
 15. 17. A method for preventing, treating, or ameliorating a medical condition, comprising administering to a mammalian subject a therapeutically effective amount of the polynucleotide of claim
 1. 18. A method of diagnosing a pathological condition or a susceptibility to a pathological condition in a subject comprising: (a) determining the presence or absence of a mutation in the polynucleotide of claim 1; and (b) diagnosing a pathological condition or a susceptibility to a pathological condition based on the presence or absence of said mutation.
 19. A method of diagnosing a pathological condition or a susceptibility to a pathological condition in a subject comprising: (a) determining the presence or amount of expression of the polypeptide of claim 11 in a biological sample; and (b) diagnosing a pathological condition or a susceptibility to a pathological condition based on the presence or amount of expression of the polypeptide.
 20. A method for identifying a binding partner to the polypeptide of claim 11 comprising: (a) contacting the polypeptide of claim 11 with a binding partner; and (b) determining whether the binding partner effects an activity of the polypeptide.
 21. The gene corresponding to the cDNA sequence of SEQ ID NO: Y.
 22. A method of identifying an activity in a biological assay, wherein the method comprises: (a) expressing SEQ ID NO: X in a cell; (b) isolating the supernatant; (c) detecting an activity in a biological assay; and identifying the protein in the supernatant having the activity.
 23. The product produced by the method of claim
 20. 24. A method for preventing, treating, or ameliorating a medical condition, comprising administering to a mammalian subject a therapeutically effective amount of the polypeptide of claim
 11. 